DK1631312T3 - Sammensætning og fremstillingsmåde til behandling af inflammatorisk tarmsygdom - Google Patents

Sammensætning og fremstillingsmåde til behandling af inflammatorisk tarmsygdom

Info

Publication number
DK1631312T3
DK1631312T3 DK04750581T DK04750581T DK1631312T3 DK 1631312 T3 DK1631312 T3 DK 1631312T3 DK 04750581 T DK04750581 T DK 04750581T DK 04750581 T DK04750581 T DK 04750581T DK 1631312 T3 DK1631312 T3 DK 1631312T3
Authority
DK
Denmark
Prior art keywords
inflammatory bowel
bowel disease
treatment
composition
type
Prior art date
Application number
DK04750581T
Other languages
English (en)
Inventor
Lesley B Pickford
Christopher R Bebbington
Geoffrey T Yarranton
David King
Original Assignee
Medarex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medarex Inc filed Critical Medarex Inc
Application granted granted Critical
Publication of DK1631312T3 publication Critical patent/DK1631312T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK04750581T 2003-04-23 2004-04-23 Sammensætning og fremstillingsmåde til behandling af inflammatorisk tarmsygdom DK1631312T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46515503P 2003-04-23 2003-04-23
PCT/US2004/012651 WO2004093908A2 (en) 2003-04-23 2004-04-23 Compositions and methods for the therapy of inflammatory bowel disease

Publications (1)

Publication Number Publication Date
DK1631312T3 true DK1631312T3 (da) 2009-01-19

Family

ID=33311000

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04750581T DK1631312T3 (da) 2003-04-23 2004-04-23 Sammensætning og fremstillingsmåde til behandling af inflammatorisk tarmsygdom

Country Status (22)

Country Link
US (2) US7939076B2 (da)
EP (1) EP1631312B1 (da)
JP (1) JP4628357B2 (da)
KR (1) KR100817351B1 (da)
CN (2) CN101318019B (da)
AT (1) ATE407698T1 (da)
AU (1) AU2004232362C1 (da)
BR (1) BRPI0410495A (da)
CA (2) CA2522957C (da)
DE (1) DE602004016499D1 (da)
DK (1) DK1631312T3 (da)
ES (1) ES2313039T3 (da)
HK (1) HK1082200A1 (da)
IL (1) IL171356A (da)
MX (1) MXPA05011409A (da)
NZ (1) NZ542866A (da)
PL (1) PL1631312T3 (da)
PT (1) PT1631312E (da)
SG (1) SG173919A1 (da)
SI (1) SI1631312T1 (da)
WO (1) WO2004093908A2 (da)
ZA (1) ZA200508390B (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ542866A (en) 2003-04-23 2009-07-31 Medarex Inc Compositions and methods for the therapy of inflammatory bowel disease
ES2368737T3 (es) * 2003-04-23 2011-11-21 Medarex, Inc. Anticuerpos humanizados contra el receptor de interferon alfa 1 (ifnar-1).
US8501198B2 (en) 2004-06-07 2013-08-06 Qu Biologics Inc. Tissue targeted antigenic activation of the immune response to treat cancers
US9107864B2 (en) 2004-06-07 2015-08-18 Qu Biologics Inc. Tissue targeted antigenic activation of the immune response to treat cancers
AU2005258077C1 (en) 2004-06-21 2012-10-25 E. R. Squibb & Sons, L.L.C. Interferon alpha receptor 1 antibodies and their uses
KR101166901B1 (ko) 2010-04-16 2012-07-19 송영완 임플란트용 주입기
JP2013528622A (ja) * 2010-06-04 2013-07-11 ザ・ブリガーム・アンド・ウーメンズ・ホスピタル・インコーポレーテッド 炎症性障害の処置
KR102157718B1 (ko) * 2010-07-26 2020-09-18 큐 바이올로직스 인코포레이티드 면역원성 소염 조성물
US8906668B2 (en) 2012-11-23 2014-12-09 Seres Health, Inc. Synergistic bacterial compositions and methods of production and use thereof
KR102222273B1 (ko) 2013-02-04 2021-03-08 세레스 테라퓨틱스, 인코포레이티드 조성물 및 방법
EP2951283A4 (en) 2013-02-04 2017-01-25 Seres Therapeutics, Inc. Compositions and methods
AU2014232370B2 (en) 2013-03-15 2018-11-01 Seres Therapeutics, Inc. Network-based microbial compositions and methods
KR102379658B1 (ko) 2013-11-25 2022-03-28 세레스 테라퓨틱스, 인코포레이티드 상승적 박테리아 조성물 및 그것의 생산 방법 및 용도
US9956282B2 (en) 2013-12-16 2018-05-01 Seres Therapeutics, Inc. Bacterial compositions and methods of use thereof for treatment of immune system disorders
AU2015252726B2 (en) 2014-05-02 2020-12-24 Qu Biologics Inc. Anti-microbial immunomodulation
EP3179985A1 (en) * 2014-08-14 2017-06-21 Brown University Compositions for stabilizing and delivering proteins
WO2016100301A1 (en) 2014-12-15 2016-06-23 The Brigham And Women's Hospital, Inc. Use of cadherin-11 antagonists to treat obesity-associated conditions and other metabolic disorders
WO2018010140A1 (zh) 2016-07-14 2018-01-18 中国科学院生物物理研究所 I型干扰素受体抗体及其用途
EP3630146A1 (en) * 2017-06-02 2020-04-08 Goodgut S.L. Grape skin for use in the treatment of dysbiosis
EP3668527A1 (en) 2017-08-14 2020-06-24 Seres Therapeutics, Inc. Compositions and methods for treating cholestatic disease
EP3672986A1 (en) 2017-08-22 2020-07-01 Sanabio, LLC Soluble interferon receptors and uses thereof
CN112056275B (zh) * 2020-09-27 2022-05-10 澎立生物医药技术(上海)有限公司 一种肠粘膜炎动物模型及其构建方法和应用

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5516515A (en) * 1986-02-05 1996-05-14 Interferon Sciences, Inc. Separation of alpha interferon receptor proteins and antibodies therefor
IL78444A (en) * 1986-04-08 1992-05-25 Yeda Res & Dev Human gamma interferon-specific receptor protein,antibody against said protein,and compositions containing said protein and antibody
IL88377A (en) 1988-11-14 1996-09-12 Yeda Res & Dev Cloning and expression of a protein which modulates cellular response to type I interferon
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5889151A (en) * 1989-10-20 1999-03-30 Societe Leb-Tech Purified human alpha interferon receptor
FR2653445B1 (fr) 1989-10-20 1994-07-29 Centre Nat Rech Scient Fragment d'adnc codant pour le gene du recepteur de l'interferon alpha et procede de preparation d'une proteine correspondante.
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
US6300129B1 (en) 1990-08-29 2001-10-09 Genpharm International Transgenic non-human animals for producing heterologous antibodies
EP0601052B1 (en) 1991-08-30 1996-10-16 Genentech, Inc. Therapeutic method for the treatment of iddm
EP0563487A1 (en) * 1992-03-31 1993-10-06 Laboratoire Europeen De Biotechnologie S.A. Monoclonal antibodies against the interferon receptor, with neutralizing activity against type I interferon
US5821078A (en) * 1992-09-03 1998-10-13 Yeda Research And Development Co. Ltd. Nucleic acid encoding interferon-α/β binding protein
WO1994014467A1 (en) * 1992-12-29 1994-07-07 Genentech, Inc. Treatment of inflammatory bowel disease with ifn-gamma inhibitors
US5888511A (en) * 1993-02-26 1999-03-30 Advanced Biotherapy Concepts, Inc. Treatment of autoimmune diseases, including AIDS
AU7782894A (en) * 1993-09-17 1995-04-03 Laboratoire Europeen De Biotechnologie S.A. Pharmaceutical composition comprising monoclonal antibodies against the interferon receptor, with neutralizing activity against type i interferon
AU1289595A (en) 1993-11-15 1995-06-06 Cell Therapeutics, Inc. Method for selectively inhibiting il-2 signal transduction
US7285526B2 (en) * 1995-07-14 2007-10-23 Meiogen Biotechnology Corporation Interferon antagonists useful for the treatment of interferon related diseases
IL118096A0 (en) 1996-05-01 1996-09-12 Yeda Res & Dev Antibodies against interferon alpha/beta receptor
US6713609B1 (en) * 1996-07-16 2004-03-30 Genentech, Inc. Monoclonal antibodies to type I interferon receptor
JP2002512624A (ja) 1997-05-21 2002-04-23 バイオベーション リミテッド 非免疫原性タンパク質の製造方法
FR2769505B1 (fr) 1997-10-10 2000-06-30 Michael Gerard Tovey Compositions de cytokines a administrer a la muqueuse buccale, et leurs utilisations
ES2229673T3 (es) * 1998-01-30 2009-08-04 Allertein Therapeutics, Llc Ensayo para pronosticar alergia o inflamacion.
AUPP670698A0 (en) 1998-10-23 1998-11-19 Monash University A method of regulation
US6329159B1 (en) * 1999-03-11 2001-12-11 Millennium Pharmaceuticals, Inc. Anti-GPR-9-6 antibodies and methods of identifying agents which modulate GPR-9-6 function
DE60037896D1 (de) 1999-07-29 2008-03-13 Medarex Inc Menschliche antikörper gegen her2/neu
EP1792991A1 (en) 1999-08-24 2007-06-06 Medarex, Inc. Human CTLA-4 antibodies and their uses
US6264981B1 (en) * 1999-10-27 2001-07-24 Anesta Corporation Oral transmucosal drug dosage using solid solution
GB0001712D0 (en) * 2000-01-25 2000-03-15 Pharma Pacific Pty Ltd Therapeutic peptides
GB0001710D0 (en) 2000-01-25 2000-03-15 Pharma Pacific Pty Ltd Therapeutic treatment
US7041870B2 (en) 2000-11-30 2006-05-09 Medarex, Inc. Transgenic transchromosomal rodents for making human antibodies
US7087726B2 (en) * 2001-02-22 2006-08-08 Genentech, Inc. Anti-interferon-α antibodies
JP4156324B2 (ja) 2002-09-30 2008-09-24 ローム株式会社 直流−交流変換装置、及び交流電力供給方法
ES2368737T3 (es) * 2003-04-23 2011-11-21 Medarex, Inc. Anticuerpos humanizados contra el receptor de interferon alfa 1 (ifnar-1).
NZ542866A (en) 2003-04-23 2009-07-31 Medarex Inc Compositions and methods for the therapy of inflammatory bowel disease
PT1711207E (pt) * 2003-12-10 2013-02-13 Medarex Inc Anticorpos alfa interferão e seus usos
AU2005258077C1 (en) * 2004-06-21 2012-10-25 E. R. Squibb & Sons, L.L.C. Interferon alpha receptor 1 antibodies and their uses

Also Published As

Publication number Publication date
JP2006524703A (ja) 2006-11-02
US20110165158A1 (en) 2011-07-07
CA2823468A1 (en) 2004-11-04
WO2004093908A3 (en) 2005-06-02
AU2004232362A1 (en) 2004-11-04
US20050152901A1 (en) 2005-07-14
ES2313039T3 (es) 2009-03-01
EP1631312A2 (en) 2006-03-08
PL1631312T3 (pl) 2009-02-27
CN1777444A (zh) 2006-05-24
SI1631312T1 (sl) 2009-02-28
MXPA05011409A (es) 2005-12-12
EP1631312B1 (en) 2008-09-10
JP4628357B2 (ja) 2011-02-09
HK1082200A1 (en) 2006-06-02
ATE407698T1 (de) 2008-09-15
AU2004232362B2 (en) 2007-09-06
WO2004093908A2 (en) 2004-11-04
ZA200508390B (en) 2006-06-28
US7939076B2 (en) 2011-05-10
AU2004232362C1 (en) 2008-05-29
IL171356A (en) 2010-11-30
CA2522957A1 (en) 2004-11-04
CA2522957C (en) 2013-10-22
CN101318019A (zh) 2008-12-10
BRPI0410495A (pt) 2006-06-13
SG173919A1 (en) 2011-09-29
CN101318019B (zh) 2012-08-29
NZ542866A (en) 2009-07-31
CN100409897C (zh) 2008-08-13
PT1631312E (pt) 2008-12-22
KR20060015531A (ko) 2006-02-17
DE602004016499D1 (de) 2008-10-23
US8828393B2 (en) 2014-09-09
KR100817351B1 (ko) 2008-03-26

Similar Documents

Publication Publication Date Title
IL171356A (en) Anti-interferon receptor antibody for treatment of inflammatory bowel disease
HRP20181459T1 (hr) Humanizirani antagonisti anti-beta7 i njihove uporabe
NO20091734L (no) Glucagonreseptorantagonistforbindelser, preparater inneholdende slike forbindelser, og metoder for anvendelse
DK1874818T3 (da) TGF-Beta 1-specifikke antistoffer
DK1773885T3 (da) Humaniserede anti-c-met-antagonister
DE60142614D1 (de) Inität
BR0315161A (pt) Anticorpo isolado, polinicleotìdeo isolado, vetor, célula hospedeira, método de produzir um anticorpo, e, composição
PE20061115A1 (es) Anticuerpos anti-il-12, epitopos, composiciones, metodos y usos
ATE387435T1 (de) Substituirte benzosulfonamide als potenzierungsmittel von glutamatrezeptoren
ATE517920T1 (de) Humanisierte antikörper gegen interferon-alpha- rezeptor-1 (ifnar-1)
DK1383919T3 (da) Fremgangsmåder og sammensætninger til anvendelse af MHC klasse II-invariant kædepolypeptid som en receptor for makrofag migrationsinhiberede faktor
ATE517340T1 (de) Sätze gegen kurze epitope gerichteter digitaler antikörper sowie diese verwendende verfahren
NO20054238D0 (no) Inhibitorer av antigenpresentasjon ved MHC klasse II-molekyler og fremgangsmate for anvendelse av disse
EA200601220A1 (ru) Анти-trkc антитела-агонисты и способы их применения