AR103675A1 - Anticuerpos anti-ctla4 terapéuticos - Google Patents
Anticuerpos anti-ctla4 terapéuticosInfo
- Publication number
- AR103675A1 AR103675A1 ARP160100391A ARP160100391A AR103675A1 AR 103675 A1 AR103675 A1 AR 103675A1 AR P160100391 A ARP160100391 A AR P160100391A AR P160100391 A ARP160100391 A AR P160100391A AR 103675 A1 AR103675 A1 AR 103675A1
- Authority
- AR
- Argentina
- Prior art keywords
- antibodies
- diseases
- ctla4
- derivatives
- fragments
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Composiciones y métodos relacionados o derivados de anticuerpos anti-CTLA4. Más específicamente, se divulgan anticuerpos completamente humanos que se unen a CTLA4, fragmentos de unión al anticuerpo CTLA4 y derivados de dichos anticuerpos, y polipéptidos de unión a CTLA4 que comprenden dichos fragmentos. Aún más, se divulgan ácidos nucleicos que codifican dichos anticuerpos, fragmentos de anticuerpo y derivados y polipéptidos, células que comprenden dichos polinucleótidos, métodos de elaboración de dichos anticuerpos, fragmentos de anticuerpo y derivados y polipéptidos, y métodos de uso de dichos anticuerpos, fragmentos de anticuerpo y derivados y polipéptidos, incluyendo métodos de tratamiento de una enfermedad que requiere ya sea estimulación o supresión de respuestas inmunológicas. La estimulación se logra usando anticuerpos que bloquean la unión de la CTLA4 humana a la B7 humana y las enfermedades susceptibles al tratamiento mediante estimulación y a un aumento de una prolongación de las respuestas inmunológicas incluyen cánceres de próstata, riñón, colon, pulmón o mama; infecciones patógenas; enfermedades asociadas con el SNC, por ejemplo enfermedades amiloidogénicas incluyendo el mal de Alzheimer; y enfermedades con componentes inflamatorios o alérgicos. Las enfermedades susceptibles de tratamiento incluyen enfermedad de injerto versus huésped, enfermedad de huésped versus injerto, alergia, enfermedades autoinmunes y otras enfermedades inflamatorias.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562116353P | 2015-02-13 | 2015-02-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR103675A1 true AR103675A1 (es) | 2017-05-24 |
Family
ID=56614957
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP160100391A AR103675A1 (es) | 2015-02-13 | 2016-02-12 | Anticuerpos anti-ctla4 terapéuticos |
Country Status (13)
Country | Link |
---|---|
US (3) | US10202453B2 (es) |
EP (3) | EP3256165B1 (es) |
JP (3) | JP6917902B2 (es) |
KR (1) | KR20180006367A (es) |
CN (2) | CN108271359B (es) |
AR (1) | AR103675A1 (es) |
AU (2) | AU2016219170B2 (es) |
CA (1) | CA2976446A1 (es) |
ES (1) | ES2882157T3 (es) |
IL (3) | IL292578A (es) |
MX (3) | MX2017010412A (es) |
TW (1) | TW201636369A (es) |
WO (2) | WO2016130986A1 (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
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US20160075772A1 (en) * | 2014-09-12 | 2016-03-17 | Regeneron Pharmaceuticals, Inc. | Treatment of Fibrodysplasia Ossificans Progressiva |
EP3256165B1 (en) * | 2015-02-13 | 2021-07-14 | Sorrento Therapeutics, Inc. | Antibody therapeutics that bind ctla4 |
PT3303394T (pt) | 2015-05-29 | 2020-07-01 | Ludwig Inst For Cancer Res Ltd | Anticorpos anti-ctla-4 e métodos de uso dos mesmos |
MA42459A (fr) | 2015-07-16 | 2018-05-23 | Bioxcel Therapeutics Inc | Nouvelle approche pour le traitement du cancer par immunomodulation |
US11542332B2 (en) | 2016-03-26 | 2023-01-03 | Bioatla, Inc. | Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof |
RU2756236C2 (ru) | 2016-06-20 | 2021-09-28 | Кимаб Лимитед | PD-L1 специфические антитела |
WO2018035710A1 (en) | 2016-08-23 | 2018-03-01 | Akeso Biopharma, Inc. | Anti-ctla4 antibodies |
US10618962B2 (en) * | 2016-10-10 | 2020-04-14 | Crown Bioscience (Taicang) Inc. | Anti-CTLA4 antibodies |
AU2017373944B2 (en) | 2016-12-07 | 2022-02-03 | Agenus Inc. | Anti-CTLA-4 antibodies and methods of use thereof |
US11319372B2 (en) | 2017-02-21 | 2022-05-03 | Remd Biotherapeutics, Inc. | Cancer treatment using antibodies that bind cytotoxic T-lymphocyte antigen-4 (CTLA-4) |
EP3597735A4 (en) * | 2017-03-15 | 2020-11-25 | Suzhou Galaxy Biopharma, Co., Ltd. | CTLA4 ANTIBODIES, PHARMACEUTICAL COMPOSITION AND USES THEREOF |
EA201992755A1 (ru) * | 2017-05-19 | 2020-04-22 | Уси Байолоджикс (Шанхай) Ко. Лтд. | Новые моноклональные антитела к белку 4, ассоциированному с цитотоксическими т-лимфоцитами, (ctla-4) |
TWI799432B (zh) * | 2017-07-27 | 2023-04-21 | 美商再生元醫藥公司 | 抗ctla-4抗體及其用途 |
WO2019036855A1 (en) | 2017-08-21 | 2019-02-28 | Adagene Inc. | ANTI-CD137 MOLECULES AND THEIR USE |
EP4295915A3 (en) * | 2017-12-20 | 2024-05-22 | Harbour Biomed (Shanghai) Co., Ltd | Antibodies binding ctla-4 and uses thereof |
WO2019148444A1 (en) * | 2018-02-02 | 2019-08-08 | Adagene Inc. | Anti-ctla4 antibodies and methods of making and using the same |
WO2019148445A1 (en) | 2018-02-02 | 2019-08-08 | Adagene Inc. | Precision/context-dependent activatable antibodies, and methods of making and using the same |
CA3101614A1 (en) * | 2018-05-31 | 2019-12-05 | Sorrento Therapeutics, Inc. | Drug delivery methods targeting the lymphatic system |
US20210236547A1 (en) * | 2018-06-05 | 2021-08-05 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Rapid production, expansion, and increased purity of car-t cells using beads with protein l |
CN110760002A (zh) * | 2018-07-25 | 2020-02-07 | 南京金斯瑞生物科技有限公司 | 人源化抗人ctla4单克隆抗体及其制备方法和用途 |
MX2021005048A (es) * | 2018-10-31 | 2021-09-08 | Bioatla Inc | Anticuerpos anti-ctla4, fragmentos de anticuerpos, sus inmunoconjugados y usos. |
US20230071889A1 (en) | 2018-12-21 | 2023-03-09 | Ose Immunotherapeutics | Bifunctional anti-pd-1/il-7 molecule |
SG11202106764YA (en) * | 2018-12-27 | 2021-07-29 | Gigagen Inc | Anti-ctla-4 binding proteins and methods of use thereof |
WO2020165374A1 (en) | 2019-02-14 | 2020-08-20 | Ose Immunotherapeutics | Bifunctional molecule comprising il-15ra |
EP3996735A4 (en) * | 2019-07-12 | 2023-07-19 | The Research Foundation for The State University of New York | COMPOSITIONS AND METHODS FOR BLOCKING AND BINDING CXCR4 TO MODULATE CELLULAR FUNCTION |
WO2021122866A1 (en) | 2019-12-17 | 2021-06-24 | Ose Immunotherapeutics | Bifunctional molecules comprising an il-7 variant |
EP4110810A1 (en) | 2020-02-28 | 2023-01-04 | Orega Biotech | Combination therapies based on ctla4 and il-17b inhibitors |
WO2022112198A1 (en) | 2020-11-24 | 2022-06-02 | Worldwide Innovative Network | Method to select the optimal immune checkpoint therapies |
EP4320156A1 (en) | 2021-04-09 | 2024-02-14 | Ose Immunotherapeutics | Scaffold for bifunctioanl molecules comprising pd-1 or cd28 and sirp binding domains |
IL307419A (en) | 2021-04-09 | 2023-12-01 | Ose Immunotherapeutics | A new scaffold for bifunctional molecules with improved properties |
WO2024003360A1 (en) | 2022-07-01 | 2024-01-04 | Institut Curie | Biomarkers and uses thereof for the treatment of neuroblastoma |
WO2024028386A1 (en) | 2022-08-02 | 2024-02-08 | Ose Immunotherapeutics | Multifunctional molecule directed against cd28 |
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EP3256165B1 (en) * | 2015-02-13 | 2021-07-14 | Sorrento Therapeutics, Inc. | Antibody therapeutics that bind ctla4 |
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2016
- 2016-02-12 EP EP16749944.1A patent/EP3256165B1/en active Active
- 2016-02-12 MX MX2017010412A patent/MX2017010412A/es unknown
- 2016-02-12 JP JP2017560892A patent/JP6917902B2/ja active Active
- 2016-02-12 CN CN201680015455.8A patent/CN108271359B/zh active Active
- 2016-02-12 EP EP22189031.2A patent/EP4151231A1/en active Pending
- 2016-02-12 KR KR1020177025857A patent/KR20180006367A/ko not_active Application Discontinuation
- 2016-02-12 WO PCT/US2016/017859 patent/WO2016130986A1/en active Application Filing
- 2016-02-12 CN CN202111220911.1A patent/CN114014930A/zh active Pending
- 2016-02-12 AU AU2016219170A patent/AU2016219170B2/en active Active
- 2016-02-12 EP EP21183628.3A patent/EP3949984A1/en not_active Withdrawn
- 2016-02-12 WO PCT/US2016/017713 patent/WO2016130898A2/en active Application Filing
- 2016-02-12 IL IL292578A patent/IL292578A/en unknown
- 2016-02-12 ES ES16749944T patent/ES2882157T3/es active Active
- 2016-02-12 AR ARP160100391A patent/AR103675A1/es unknown
- 2016-02-12 US US15/043,157 patent/US10202453B2/en active Active
- 2016-02-12 CA CA2976446A patent/CA2976446A1/en active Pending
- 2016-02-15 TW TW105104408A patent/TW201636369A/zh unknown
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2017
- 2017-08-11 IL IL253963A patent/IL253963B/en unknown
- 2017-08-11 MX MX2022011935A patent/MX2022011935A/es unknown
- 2017-08-11 MX MX2021007947A patent/MX2021007947A/es unknown
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2019
- 2019-01-08 US US16/243,016 patent/US11155623B2/en active Active
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2021
- 2021-01-05 JP JP2021000465A patent/JP2021054857A/ja not_active Withdrawn
- 2021-06-23 IL IL284336A patent/IL284336B/en unknown
- 2021-09-22 US US17/482,138 patent/US20220002415A1/en active Pending
- 2021-12-08 AU AU2021282431A patent/AU2021282431A1/en active Pending
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2022
- 2022-04-01 JP JP2022061876A patent/JP2022084942A/ja not_active Withdrawn
Also Published As
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