MX2022011935A - Terapeuticos de anticuerpo que se unen a ctla4. - Google Patents

Terapeuticos de anticuerpo que se unen a ctla4.

Info

Publication number
MX2022011935A
MX2022011935A MX2022011935A MX2022011935A MX2022011935A MX 2022011935 A MX2022011935 A MX 2022011935A MX 2022011935 A MX2022011935 A MX 2022011935A MX 2022011935 A MX2022011935 A MX 2022011935A MX 2022011935 A MX2022011935 A MX 2022011935A
Authority
MX
Mexico
Prior art keywords
ctla4
antibodies
derivatives
polypeptides
methods
Prior art date
Application number
MX2022011935A
Other languages
English (en)
Inventor
John Dixon Gray
Heyue Zhou
Original Assignee
Sorrento Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sorrento Therapeutics Inc filed Critical Sorrento Therapeutics Inc
Publication of MX2022011935A publication Critical patent/MX2022011935A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente descripción proporciona composiciones y métodos y kits que se refieren a anticuerpos anti-CTLA4. De manera más específica, se proporcionan anticuerpos completamente humanos que se unen a CTLA4, fragmentos de unión de anticuerpo a CTLA4 y derivados de tales anticuerpos y polipéptidos de unión a CTLA4 que comprenden tales fragmentos. Aún más, se describen ácidos nucleicos que codifican tales anticuerpos, fragmentos de anticuerpo y derivados y polipéptidos, células que comprenden tales polinucleótidos, métodos para hacer tales anticuerpos, fragmentos de anticuerpo y derivados y polipéptidos y métodos para usar tales anticuerpos, fragmentos de anticuerpos, fragmentos de anticuerpo y derivados y polipéptidos, incluyendo métodos para tratar una enfermedad que requiere ya sea estimulación de respuestas inmunes o supresión. En un aspecto, la presente descripción proporciona un anticuerpo anti-CTLA4 completamente humano aislado de una clase de IgG que se une a un epitope de CTLA4 con una afinidad de unión de al menos 10-6 M.
MX2022011935A 2015-02-13 2017-08-11 Terapeuticos de anticuerpo que se unen a ctla4. MX2022011935A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562116353P 2015-02-13 2015-02-13

Publications (1)

Publication Number Publication Date
MX2022011935A true MX2022011935A (es) 2022-10-20

Family

ID=56614957

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2017010412A MX384026B (es) 2015-02-13 2016-02-12 Terapeuticos de anticuerpo que se unen a ctla4.
MX2022011935A MX2022011935A (es) 2015-02-13 2017-08-11 Terapeuticos de anticuerpo que se unen a ctla4.
MX2021007947A MX2021007947A (es) 2015-02-13 2017-08-11 Terapeuticos de anticuerpo que se unen a ctla4.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2017010412A MX384026B (es) 2015-02-13 2016-02-12 Terapeuticos de anticuerpo que se unen a ctla4.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2021007947A MX2021007947A (es) 2015-02-13 2017-08-11 Terapeuticos de anticuerpo que se unen a ctla4.

Country Status (13)

Country Link
US (3) US10202453B2 (es)
EP (3) EP3949984A1 (es)
JP (3) JP6917902B2 (es)
KR (1) KR20180006367A (es)
CN (2) CN108271359B (es)
AR (1) AR103675A1 (es)
AU (2) AU2016219170B2 (es)
CA (1) CA2976446A1 (es)
ES (1) ES2882157T3 (es)
IL (3) IL292578A (es)
MX (3) MX384026B (es)
TW (1) TW201636369A (es)
WO (2) WO2016130898A2 (es)

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Also Published As

Publication number Publication date
IL253963B (en) 2021-07-29
EP3949984A1 (en) 2022-02-09
JP2021054857A (ja) 2021-04-08
AU2021282431A1 (en) 2021-12-23
US20160237154A1 (en) 2016-08-18
MX384026B (es) 2025-03-14
CN108271359B (zh) 2021-11-09
CN114014930A (zh) 2022-02-08
IL292578A (en) 2022-06-01
WO2016130898A3 (en) 2016-10-20
IL253963A0 (en) 2017-10-31
US10202453B2 (en) 2019-02-12
CA2976446A1 (en) 2016-08-18
TW201636369A (zh) 2016-10-16
US11155623B2 (en) 2021-10-26
AR103675A1 (es) 2017-05-24
US20220002415A1 (en) 2022-01-06
AU2016219170A1 (en) 2017-09-21
WO2016130986A1 (en) 2016-08-18
JP2022084942A (ja) 2022-06-07
CN108271359A (zh) 2018-07-10
MX2017010412A (es) 2018-07-06
IL284336A (en) 2021-07-29
EP3256165B1 (en) 2021-07-14
JP6917902B2 (ja) 2021-08-11
KR20180006367A (ko) 2018-01-17
JP2018508573A (ja) 2018-03-29
IL284336B (en) 2022-06-01
WO2016130898A2 (en) 2016-08-18
EP3256165A4 (en) 2018-10-24
US20190127469A1 (en) 2019-05-02
AU2016219170B2 (en) 2021-09-09
ES2882157T3 (es) 2021-12-01
MX2021007947A (es) 2021-08-16
EP4151231A1 (en) 2023-03-22
EP3256165A2 (en) 2017-12-20

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