MX2017010412A - Terapeuticos de anticuerpos que se unen a ctla4. - Google Patents
Terapeuticos de anticuerpos que se unen a ctla4.Info
- Publication number
- MX2017010412A MX2017010412A MX2017010412A MX2017010412A MX2017010412A MX 2017010412 A MX2017010412 A MX 2017010412A MX 2017010412 A MX2017010412 A MX 2017010412A MX 2017010412 A MX2017010412 A MX 2017010412A MX 2017010412 A MX2017010412 A MX 2017010412A
- Authority
- MX
- Mexico
- Prior art keywords
- ctla4
- antibodies
- derivatives
- polypeptides
- methods
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente descripción proporciona composiciones y métodos y kits que se refieren a anticuerpos anti-CTLA4. De manera más específica, se proporcionan anticuerpos completamente humanos que se unen a CTLA4, fragmentos de unión de anticuerpo a CTLA4 y derivados de tales anticuerpos y polipéptidos de unión a CTLA4 que comprenden tales fragmentos. Aún más, se describen ácidos nucleicos que codifican tales anticuerpos, fragmentos de anticuerpo y derivados y polipéptidos, células que comprenden tales polinucleótidos, métodos para hacer tales anticuerpos, fragmentos de anticuerpo y derivados y polipéptidos y métodos para usar tales anticuerpos, fragmentos de anticuerpos, fragmentos de anticuerpo y derivados y polipéptidos, incluyendo métodos para tratar una enfermedad que requiere ya sea estimulación de respuestas inmunes o supresión. En un aspecto, la presente descripción proporciona un anticuerpo anti-CTLA4 completamente humano aislado de una clase de IgG que se une a un epitope de CTLA4 con una afinidad de unión de al menos 10-6 M.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562116353P | 2015-02-13 | 2015-02-13 | |
PCT/US2016/017713 WO2016130898A2 (en) | 2015-02-13 | 2016-02-12 | Antibody therapeutics that bind ctla4 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2017010412A true MX2017010412A (es) | 2018-07-06 |
Family
ID=56614957
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017010412A MX2017010412A (es) | 2015-02-13 | 2016-02-12 | Terapeuticos de anticuerpos que se unen a ctla4. |
MX2022011935A MX2022011935A (es) | 2015-02-13 | 2017-08-11 | Terapeuticos de anticuerpo que se unen a ctla4. |
MX2021007947A MX2021007947A (es) | 2015-02-13 | 2017-08-11 | Terapeuticos de anticuerpo que se unen a ctla4. |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022011935A MX2022011935A (es) | 2015-02-13 | 2017-08-11 | Terapeuticos de anticuerpo que se unen a ctla4. |
MX2021007947A MX2021007947A (es) | 2015-02-13 | 2017-08-11 | Terapeuticos de anticuerpo que se unen a ctla4. |
Country Status (13)
Country | Link |
---|---|
US (3) | US10202453B2 (es) |
EP (3) | EP3256165B1 (es) |
JP (3) | JP6917902B2 (es) |
KR (1) | KR20180006367A (es) |
CN (2) | CN108271359B (es) |
AR (1) | AR103675A1 (es) |
AU (2) | AU2016219170B2 (es) |
CA (1) | CA2976446A1 (es) |
ES (1) | ES2882157T3 (es) |
IL (3) | IL292578A (es) |
MX (3) | MX2017010412A (es) |
TW (1) | TW201636369A (es) |
WO (2) | WO2016130986A1 (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20160075772A1 (en) * | 2014-09-12 | 2016-03-17 | Regeneron Pharmaceuticals, Inc. | Treatment of Fibrodysplasia Ossificans Progressiva |
WO2016130986A1 (en) * | 2015-02-13 | 2016-08-18 | Sorrento Therapeutics, Inc. | Antibody therapeutics that bind ctla4 |
CN113603784A (zh) | 2015-05-29 | 2021-11-05 | 艾吉纳斯公司 | 抗-ctla-4抗体及其使用方法 |
KR20180036974A (ko) | 2015-07-16 | 2018-04-10 | 바이오엑셀 테라퓨틱스 인코포레이티드 | 면역조절을 이용하는 암의 치료를 위한 신규한 접근법 |
US11542332B2 (en) | 2016-03-26 | 2023-01-03 | Bioatla, Inc. | Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof |
KR102379464B1 (ko) | 2016-06-20 | 2022-03-29 | 키맵 리미티드 | 항-pd-l1 항체 |
WO2018035710A1 (en) | 2016-08-23 | 2018-03-01 | Akeso Biopharma, Inc. | Anti-ctla4 antibodies |
JP6976322B2 (ja) * | 2016-10-10 | 2021-12-08 | クラウン バイオサイエンス,インコーポレイテッド(タイツァン) | 新規抗ctla4抗体 |
MD3551660T2 (ro) | 2016-12-07 | 2024-03-31 | Agenus Inc | Anticorpi anti-CTLA-4 și procedee de utilizare a acestora |
EP3585430A4 (en) * | 2017-02-21 | 2020-12-09 | REMD Biotherapeutics, Inc. | TREATMENT OF CANCER WITH ANTIBODIES THAT BIND TO T-CYTOTOXIC T-LYMPHOCYTES ANTIGEN-4 (CTLA-4) |
JP2020513819A (ja) * | 2017-03-15 | 2020-05-21 | スージョウ ギャラクシー バイオファーマ カンパニー リミテッド | Ctla4抗体、医薬組成物およびその使用 |
KR20230053001A (ko) | 2017-05-19 | 2023-04-20 | 우시 바이올로직스 (상하이) 컴퍼니 리미티드 | 세포독성 t-림프구-관련 단백질 4 (ctla-4)에 대한 신규의 단일클론 항체 |
TWI799432B (zh) * | 2017-07-27 | 2023-04-21 | 美商再生元醫藥公司 | 抗ctla-4抗體及其用途 |
WO2019036855A1 (en) | 2017-08-21 | 2019-02-28 | Adagene Inc. | ANTI-CD137 MOLECULES AND THEIR USE |
SG11202005692WA (en) * | 2017-12-20 | 2020-07-29 | Harbour Biomed Shanghai Co Ltd | Antibodies binding ctla-4 and uses thereof |
WO2019148445A1 (en) | 2018-02-02 | 2019-08-08 | Adagene Inc. | Precision/context-dependent activatable antibodies, and methods of making and using the same |
WO2019148444A1 (en) * | 2018-02-02 | 2019-08-08 | Adagene Inc. | Anti-ctla4 antibodies and methods of making and using the same |
EP3801464A4 (en) * | 2018-05-31 | 2022-03-16 | Sorrento Therapeutics, Inc. | ANTI-LYMPHICAL SYSTEM-DIRECTED DRUG RELEASE METHODS |
WO2019236681A1 (en) * | 2018-06-05 | 2019-12-12 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Rapid production, expansion, and increased purity of car-t cells using beads with protein l |
KR20230051630A (ko) * | 2018-10-31 | 2023-04-18 | 바이오아트라, 인코퍼레이티드 | 항-ctla4 항체, 항체 단편, 이들의 면역접합체 및 그 용도 |
WO2020127377A1 (en) | 2018-12-21 | 2020-06-25 | Ose Immunotherapeutics | Bifunctional anti-pd-1/il-7 molecule |
MX2021007848A (es) * | 2018-12-27 | 2021-10-26 | Gigagen Inc | Proteinas de union a anti-ctla-4 y metodos de uso de las mismas. |
WO2020165374A1 (en) | 2019-02-14 | 2020-08-20 | Ose Immunotherapeutics | Bifunctional molecule comprising il-15ra |
WO2021011480A1 (en) * | 2019-07-12 | 2021-01-21 | The Research Foundation For The State University Of New York | Compositions and methods to block and bind cxcr4 to modulate cellular function |
AU2020406083A1 (en) | 2019-12-17 | 2022-06-16 | Ose Immunotherapeutics | Bifunctional molecules comprising an IL-7 variant |
WO2021170750A1 (en) | 2020-02-28 | 2021-09-02 | Orega Biotech | Combination therapies based on ctla4 and il-17b inhibitors |
WO2022112198A1 (en) | 2020-11-24 | 2022-06-02 | Worldwide Innovative Network | Method to select the optimal immune checkpoint therapies |
JP2024515263A (ja) | 2021-04-09 | 2024-04-08 | オーエスイー・イミュノセラピューティクス | 改善された特性を有する二機能性分子のための新規足場構造 |
WO2022214652A1 (en) | 2021-04-09 | 2022-10-13 | Ose Immunotherapeutics | Scaffold for bifunctioanl molecules comprising pd-1 or cd28 and sirp binding domains |
WO2024003360A1 (en) | 2022-07-01 | 2024-01-04 | Institut Curie | Biomarkers and uses thereof for the treatment of neuroblastoma |
WO2024028386A1 (en) | 2022-08-02 | 2024-02-08 | Ose Immunotherapeutics | Multifunctional molecule directed against cd28 |
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NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
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2016
- 2016-02-12 WO PCT/US2016/017859 patent/WO2016130986A1/en active Application Filing
- 2016-02-12 MX MX2017010412A patent/MX2017010412A/es unknown
- 2016-02-12 EP EP16749944.1A patent/EP3256165B1/en active Active
- 2016-02-12 WO PCT/US2016/017713 patent/WO2016130898A2/en active Application Filing
- 2016-02-12 ES ES16749944T patent/ES2882157T3/es active Active
- 2016-02-12 JP JP2017560892A patent/JP6917902B2/ja active Active
- 2016-02-12 CA CA2976446A patent/CA2976446A1/en not_active Abandoned
- 2016-02-12 EP EP21183628.3A patent/EP3949984A1/en not_active Withdrawn
- 2016-02-12 US US15/043,157 patent/US10202453B2/en active Active
- 2016-02-12 CN CN201680015455.8A patent/CN108271359B/zh active Active
- 2016-02-12 IL IL292578A patent/IL292578A/en unknown
- 2016-02-12 AU AU2016219170A patent/AU2016219170B2/en active Active
- 2016-02-12 EP EP22189031.2A patent/EP4151231A1/en active Pending
- 2016-02-12 AR ARP160100391A patent/AR103675A1/es unknown
- 2016-02-12 KR KR1020177025857A patent/KR20180006367A/ko not_active Application Discontinuation
- 2016-02-12 CN CN202111220911.1A patent/CN114014930A/zh active Pending
- 2016-02-15 TW TW105104408A patent/TW201636369A/zh unknown
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2017
- 2017-08-11 MX MX2022011935A patent/MX2022011935A/es unknown
- 2017-08-11 IL IL253963A patent/IL253963B/en unknown
- 2017-08-11 MX MX2021007947A patent/MX2021007947A/es unknown
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2019
- 2019-01-08 US US16/243,016 patent/US11155623B2/en active Active
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2021
- 2021-01-05 JP JP2021000465A patent/JP2021054857A/ja not_active Withdrawn
- 2021-06-23 IL IL284336A patent/IL284336B/en unknown
- 2021-09-22 US US17/482,138 patent/US20220002415A1/en active Pending
- 2021-12-08 AU AU2021282431A patent/AU2021282431A1/en active Pending
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2022
- 2022-04-01 JP JP2022061876A patent/JP2022084942A/ja not_active Withdrawn
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