WO2017055322A1 - Methods for quantifying the population of neutrophils in a tissue sample - Google Patents

Methods for quantifying the population of neutrophils in a tissue sample Download PDF

Info

Publication number
WO2017055322A1
WO2017055322A1 PCT/EP2016/073053 EP2016073053W WO2017055322A1 WO 2017055322 A1 WO2017055322 A1 WO 2017055322A1 EP 2016073053 W EP2016073053 W EP 2016073053W WO 2017055322 A1 WO2017055322 A1 WO 2017055322A1
Authority
WO
WIPO (PCT)
Prior art keywords
na
na na
steap4
cd3d
kcnj15
Prior art date
Application number
PCT/EP2016/073053
Other languages
French (fr)
Inventor
Wolf Herman Fridman
Aurélien De Reynies
Etienne BECHT
Original Assignee
INSERM (Institut National de la Santé et de la Recherche Médicale)
Université Paris Diderot - Paris 7
Université Pierre Et Marie Curie (Paris 6)
Université Paris Descartes
Ligue Nationale Contre Le Cancer
Assistance Publique-Hôpitaux De Paris (Aphp)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EPEP15306521.4 priority Critical
Priority to EP15306521 priority
Priority to EP16305886 priority
Priority to EPEP16305886.0 priority
Application filed by INSERM (Institut National de la Santé et de la Recherche Médicale), Université Paris Diderot - Paris 7, Université Pierre Et Marie Curie (Paris 6), Université Paris Descartes, Ligue Nationale Contre Le Cancer, Assistance Publique-Hôpitaux De Paris (Aphp) filed Critical INSERM (Institut National de la Santé et de la Recherche Médicale)
Publication of WO2017055322A1 publication Critical patent/WO2017055322A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

Abstract

The present invention relates to methods for quantifying the population of neutrophils in a tissue sample. In particular, the present invention relates to a method for quantifying the population of neutrophils in a tissue sample obtained from a subject comprising determining the expression level of at least one gene selected from the group consisting of CXCR2, VNN3, CYP4F3, HAL, GENE 1, FCGR3B, KCNJ15, CXCR1, STEAP4 and TNFRSF10C.

Description

METHODS FOR QUANTIFYING THE POPULATION OF NEUTROPHILS IN A

TISSUE SAMPLE

FIELD OF THE INVENTION:

The present invention relates to methods for quantifying the population of neutrophils in a tissue sample.

BACKGROUND OF THE INVENTION:

Tumors grow within a microenvironment composed of immune cells, endothelial cells, fibroblasts and adjacent normal tissue. The composition of the tumor microenvironment is of paramount importance during tumor development. Notably, infiltration by cells of the adaptive immune system helps control tumor growth and correlate with a favorable clinical outcome in most cancers. A consensual result is that infiltration with memory CD8+ T cells is associated with a favorable patient's outcome. However, there are exceptions to this rule. Notably, in clear cell renal cell carcinoma (ccRCC), where angiogenesis is highly due to mutations disrupting the HIF pathway regulating the cellular response to hypoxia, tumor-infiltration by CD8+ T cells is associated with a poor prognosis for the patient. To understand this surprising result, the inventors recently performed a comprehensive characterization of the microenvironmental components associated to CD8+ T cells' infiltration in ccRCC. It appeared that in this malignancy, CD 8+ T cells infiltration is associated with a strong infiltration by other immune cells, including B cells and cells of monocytic origin. Conversely, in colorectal cancer (CRC), it is well known that infiltration by CD8+ T cells is associated with a favorable outcome. This disease is also highly heterogeneous in terms of tumor-cell phenotypes, as up to six molecular subgroups have been described, which differ in carcinogenesis pathways, methylation profile, DNA mutational burden, and prognosis. The subgroup with the best prognosis featured a strong infiltration by cytotoxic lymphocytes. Surprisingly, the worst-prognosis subgroup also displayed a strong immune infiltration, with intermediate expression of lymphocytes' markers and a strong myeloid component, as well as a high signature of endothelial cells and fibroblasts. Further analysis revealed an increased expression of pro-inflammatory and pro-angiogenic molecules in this subgroup, which appear to originate from microenvironment's fibroblasts. Altogether, these data underline the importance of a full characterization of the immune, endothelial and fibroblastic components of the microenvironment to decipher interactions between these cell types and deliver therapies aimed at orienting inflammatory microenvironments towards a more immuneresponsive state.

SUMMARY OF THE INVENTION:

The present invention relates to methods for quantifying the population of neutrophils in a tissue sample. In particular, the present invention is defined by the claims.

DETAILED DESCRIPTION OF THE INVENTION:

The tumor microenvironment is a complex tissue which contains many distinct cell populations, and whose composition may predict prognosis and response to therapies. In the present disclosure, using samples of purified cell populations, the inventors defined specific and robust transcriptomic markers of the immune and stromal cell populations of the tumor microenvironment, and they quantitatively validated them in an in-vitro R A mixture model.

For this purpose, they developed the 'Microenvironment Cell Populations-counter' (MCP-counter) method, which, using transcriptomic data, allows a robust quantification of the abundance of immune and stromal populations in cellularly heterogeneous tissues. They present in-vitro and ex-vivo data supporting the validity of this method's estimates and they apply MCP-counter to draw a global picture of immune infiltrates across human healthy tissues and non-hematopoietic tumors, and to confirm recently-identified microenvironment-based cancer stratifications associated with overall-survival in lung adenocarcinoma, colorectal, and breast cancers.

Accordingly a first object of the present invention relates to a method for quantifying the population of neutrophils in a tissue sample obtained from a subject comprising determining the expression level of at least one gene selected from the group consisting of CXCR2, VNN3, CYP4F3, HAL, GENE 1, FCGR3B, KCNJ15, CXCR1, STEAP4 and TNFRSF10C wherein the determined expression level indicates the quantity of the population of neutrophils in the tissue sample. As used herein, the term "neutrophils" also known as "granulocytes" has its general meaning in the art. Neutrophils are a category of white blood cells characterized by the presence of granules in their cytoplasm. They are also called polymorphonuclear leukocytes (PMN, PML, or PMNL) because of the varying shapes of the nucleus, which is usually lobed into three segments. This distinguishes them from the mononuclear agranulocytes. In common parlance, the term polymorphonuclear leukocyte often refers specifically to neutrophil granulocytes, the most abundant of the granulocytes; the other types (eosinophils, basophils, and mast cells) have lower numbers. Neutrophils are produced via granulopoiesis in the bone marrow.

As used herein, the term "subject" denotes a mammal such as a rodent, a feline, a canine and a primate. Preferably, a subject according to the invention is a human.

As used herein, the term "tissue", when used in reference to a part of a body or of an organ, generally refers to an aggregation or collection of morphologically similar cells and associated accessory and support cells and intercellular matter, including extracellular matrix material, vascular supply, and fluids, acting together to perform specific functions in the body. There are generally four basic types of tissue in animals and humans including muscle, nerve, epithelial, and connective tissues.

In some embodiments, when the subject suffers from a cancer, the tissue sample is a tumor tissue sample. As used herein, the term "tumor tissue sample" means any tissue tumor sample derived from the patient. Said tissue sample is obtained for the purpose of the in vitro evaluation. In some embodiments, the tumor sample may result from the tumor resected from the patient. In some embodiments, the tumor sample may result from a biopsy performed in the primary tumour of the patient or performed in metastatic sample distant from the primary tumor of the patient. In some embodiments, the tumor tissue sample encompasses a global primary tumor (as a whole), a tissue sample from the center of the tumor, a tumor tissue sample collected prior surgery (for follow-up of patients after treatment for example), and a distant metastasis. The tumor tissue sample can, of course, be subjected to a variety of well-known post-collection preparative and storage techniques (e.g., fixation, storage, freezing, etc.). The sample can be fresh, frozen, fixed (e.g., formalin fixed), or embedded (e.g., paraffin embedded.

In some embodiments, the subject suffers from a solid cancer selected from the group consisting of bile duct cancer (e.g. periphilar cancer, distal bile duct cancer, intrahepatic bile duct cancer), bladder cancer, bone cancer (e.g. osteoblastoma, osteochrondroma, hemangioma, chondromyxoid fibroma, osteosarcoma, chondrosarcoma, fibrosarcoma, malignant fibrous histiocytoma, giant cell tumor of the bone, chordoma, lymphoma, multiple myeloma), brain and central nervous system cancer (e.g. meningioma, astocytoma, oligodendrogliomas, ependymoma, gliomas, medulloblastoma, ganglioglioma, Schwannoma, germinoma, craniopharyngioma), breast cancer (e.g. ductal carcinoma in situ, infiltrating ductal carcinoma, infiltrating, lobular carcinoma, lobular carcinoma in, situ, gynecomastia), Castleman disease (e.g. giant lymph node hyperplasia, angiofollicular lymph node hyperplasia), cervical cancer, colorectal cancer, endometrial cancer (e.g. endometrial adenocarcinoma, adenocanthoma, papillary serous adnocarcinroma, clear cell), esophagus cancer, gallbladder cancer (mucinous adenocarcinoma, small cell carcinoma), gastrointestinal carcinoid tumors (e.g. choriocarcinoma, chorioadenoma destruens), Hodgkin's disease, non-Hodgkin's lymphoma, Kaposi's sarcoma, kidney cancer (e.g. renal cell cancer), laryngeal and hypopharyngeal cancer, liver cancer (e.g. hemangioma, hepatic adenoma, focal nodular hyperplasia, hepatocellular carcinoma), lung cancer (e.g. small cell lung cancer, non-small cell lung cancer), mesothelioma, plasmacytoma, nasal cavity and paranasal sinus cancer (e.g. esthesioneuroblastoma, midline granuloma), nasopharyngeal cancer, neuroblastoma, oral cavity and oropharyngeal cancer, ovarian cancer, pancreatic cancer, penile cancer, pituitary cancer, prostate cancer, retinoblastoma, rhabdomyosarcoma (e.g. embryonal rhabdomyosarcoma, alveolar rhabdomyosarcoma, pleomorphic rhabdomyosarcoma), salivary gland cancer, skin cancer (e.g. melanoma, nonmelanoma skin cancer), stomach cancer, testicular cancer (e.g. seminoma, nonseminoma germ cell cancer), thymus cancer, thyroid cancer (e.g. follicular carcinoma, anaplastic carcinoma, poorly differentiated carcinoma, medullary thyroid carcinoma, thyroid lymphoma), vaginal cancer, vulvar cancer, and uterine cancer (e.g. uterine leiomyosarcoma).

In the present specification, the name of each of the genes of interest refers to the internationally recognised name of the corresponding gene, as found in internationally recognised gene sequences and protein sequences databases, in particular in the database from the HUGO Gene Nomenclature Committee, that is available notably at the following Internet address : http://www.gene.ucl.ac.uk/nomenclature/index.html. In the present specification, the name of each of the various biological markers of interest may also refer to the internationally recognised name of the corresponding gene, as found in the internationally recognised gene sequences and protein sequences databases ENTREZ ID, Genbank, TrEMBL or ENSEMBL. Through these internationally recognised sequence databases, the nucleic acid sequences corresponding to each of the gene of interest described herein may be retrieved by the one skilled in the art. For avoidance of doubt, each gene of the present invention is characterized with the probe set name available at the following Internet address http://genecards.weizmann.ac.il/geneannot/index.shtml and their access number available on http://www.ncbi.nlm.nih.gov/gene/ : (see Table A).

Figure imgf000006_0001
Figure imgf000007_0001

Table A: correspondence between the gene mane and the probe set name. (*) indicates that the probeset does not correspond to a known gene that is referenced in the present disclosure as GENE 1 and GENE 2 In some embodiments, the expression level of 2, 3, 4, 5, 6, 7, 8, 9 or 10 genes is determined. Typically, the combination of genes is selected from the Table 1. In some embodiments, the method of the present invention further comprises quantifying at least one further population of cells in the tissue sample.

In some embodiments, the at least one population of cells is selected from the group consisting of B cells, T cells, NK cells, cytotoxic lymphocytes, myeloid dendritic cells, cells of monocytic origin (includes monocytes, macrophages, dendritic cells), fibroblasts and endothelial cells (includes lymphatics and blood vessels).

In some embodiments, the method of the present invention further comprises determining the expression level of at least one gene representative of B cells selected from the group consisting of MS4A1, CD19, CD79A, FCRL2, CR2, PAX5, CD22, BANK1 and IGKC.

In some embodiments, the method of the present invention further comprises determining the expression level of at least one gene representative of T cells selected from the group consisting of TRATl, CD3D, THEMIS, ICOS, SIRPG, CD3G, CTLA4, CD6, CD5 and CD28.

In some embodiments, the method of the present invention further comprises determining the expression level of at least one gene representative of NK cells selected from the group consisting of KIR2DL1, KIR2DL3, NCRl, KIR3DL1, KIR3DS1, KIR3DL2, SH2D1B, CD160, GENE 2 and KIR2DL4.

In some embodiments, the method of the present invention further comprises determining the expression level of at least one gene representative of cytotoxic lymphocytes selected from the group consisting of KLRC4-KLRK1 /// KLRKl, CD8A, KLRDl, GNLY, EOMES, KLRC3, KLRC4, FGFBP2 and KLRCl /// KLRC2.

In some embodiments, the method of the present invention further comprises determining the expression level of at least one gene representative of myeloid dendritic cells selected from the group consisting of CD1E, CLECIOA, CLIC2, CD1A, WFDC21P and CD1B. In some embodiments, the method of the present invention further comprises determining the expression level of at least one gene representative of cells of monocytic origin selected from the group consisting of CSF1R, ADAP2, RASSF4, FPR3, TFEC, PLA2G7 and KYNU.

In some embodiments, the method of the present invention further comprises determining the expression level of at least one gene representative of fibroblasts selected from the group consisting of DCN, COL6A2, COL6A1, COL3A1, COLlAl, PAMRl, TAGLN and GREM1.

In some embodiments, the method of the present invention further comprises determining the expression level of at least one gene representative of endothelial cells selected from the group consisting of CDH5, EMCN, MYCT1, ELTD1, ROB04, CLEC14A, VWF, ES AM, MMRN2 and KDR.

Typically, the expression level of a gene is determined by determining the quantity of mRNA. Methods for determining the quantity of mRNA are well known in the art. For example the nucleic acid contained in the samples (e.g., cell or tissue prepared from the subject) is first extracted according to standard methods, for example using lytic enzymes or chemical solutions or extracted by nucleic-acid-binding resins following the manufacturer's instructions. The extracted mRNA is then detected by hybridization (e. g., Northern blot analysis, in situ hybridization) and/or amplification (e.g., RT-PCR). Other methods of Amplification include ligase chain reaction (LCR), transcription-mediated amplification (TMA), strand displacement amplification (SDA) and nucleic acid sequence based amplification (NASBA).

Nucleic acids having at least 10 nucleotides and exhibiting sequence complementarity or homology to the mRNA of interest herein find utility as hybridization probes or amplification primers. It is understood that such nucleic acids need not be identical, but are typically at least about 80% identical to the homologous region of comparable size, more preferably 85% identical and even more preferably 90-95% identical. In some embodiments, it will be advantageous to use nucleic acids in combination with appropriate means, such as a detectable label, for detecting hybridization. Typically, the nucleic acid probes include one or more labels, for example to permit detection of a target nucleic acid molecule using the disclosed probes. In various applications, such as in situ hybridization procedures, a nucleic acid probe includes a label (e.g., a detectable label). A "detectable label" is a molecule or material that can be used to produce a detectable signal that indicates the presence or concentration of the probe (particularly the bound or hybridized probe) in a sample. Thus, a labeled nucleic acid molecule provides an indicator of the presence or concentration of a target nucleic acid sequence (e.g., genomic target nucleic acid sequence) (to which the labeled uniquely specific nucleic acid molecule is bound or hybridized) in a sample. A label associated with one or more nucleic acid molecules (such as a probe generated by the disclosed methods) can be detected either directly or indirectly. A label can be detected by any known or yet to be discovered mechanism including absorption, emission and/ or scattering of a photon (including radio frequency, microwave frequency, infrared frequency, visible frequency and ultra-violet frequency photons). Detectable labels include colored, fluorescent, phosphorescent and luminescent molecules and materials, catalysts (such as enzymes) that convert one substance into another substance to provide a detectable difference (such as by converting a colorless substance into a colored substance or vice versa, or by producing a precipitate or increasing sample turbidity), haptens that can be detected by antibody binding interactions, and paramagnetic and magnetic molecules or materials.

Particular examples of detectable labels include fluorescent molecules (or fluorochromes). Numerous fluorochromes are known to those of skill in the art, and can be selected, for example from Life Technologies (formerly Invitrogen), e.g., see, The Handbook— A Guide to Fluorescent Probes and Labeling Technologies). Examples of particular fluorophores that can be attached (for example, chemically conjugated) to a nucleic acid molecule (such as a uniquely specific binding region) are provided in U.S. Pat. No. 5,866, 366 to Nazarenko et al., such as 4-acetamido-4'-isothiocyanatostilbene-2,2' disulfonic acid, acridine and derivatives such as acridine and acridine isothiocyanate, 5-(2'-aminoethyl) aminonaphthalene-1 -sulfonic acid (EDANS), 4-amino -N- [3 vinylsulfonyl)phenyl]naphthalimide-3,5 disulfonate (Lucifer Yellow VS), N-(4-anilino-l- naphthyl)maleimide, antllranilamide, Brilliant Yellow, coumarin and derivatives such as coumarin, 7-amino-4-methylcoumarin (AMC, Coumarin 120), 7-amino-4- trifluoromethylcouluarin (Coumarin 151); cyanosine; 4',6-diarninidino-2-phenylindole (DAPI); 5',5"dibromopyrogallol-sulfonephthalein (Bromopyrogallol Red); 7 -diethylamino -3 (4'-isothiocyanatophenyl)-4-methylcoumarin; diethylenetriamine pentaacetate; 4,4'- diisothiocyanatodihydro-stilbene-2,2'-disulfonic acid; 4,4'-diisothiocyanatostilbene-2,2'- disulforlic acid; 5-[dimethylamino] naphthalene- 1 -sulfonyl chloride (DNS, dansyl chloride); 4-(4'-dimethylaminophenylazo)benzoic acid (DABCYL); 4-dimethylaminophenylazophenyl- 4'-isothiocyanate (DABITC); eosin and derivatives such as eosin and eosin isothiocyanate; erythrosin and derivatives such as erythrosin B and erythrosin isothiocyanate; ethidium; fluorescein and derivatives such as 5-carboxyfluorescein (FAM), 5-(4,6diclllorotriazin-2- yDarninofluorescein (DTAF), 2'7'dimethoxy-4'5'-dichloro-6-carboxyfiuorescein (JOE), fluorescein, fluorescein isothiocyanate (FITC), and QFITC Q(RITC); 2',7'-difluorofiuorescein (OREGON GREEN®); fluorescamine; IR144; IR1446; Malachite Green isothiocyanate; 4- methylumbelliferone; ortho cresolphthalein; nitrotyrosine; pararosaniline; Phenol Red; B- phycoerythrin; o-phthaldialdehyde; pyrene and derivatives such as pyrene, pyrene butyrate and succinimidyl 1 -pyrene butyrate; Reactive Red 4 (Cibacron Brilliant Red 3B-A); rhodamine and derivatives such as 6-carboxy-X-rhodamine (ROX), 6-carboxyrhodamine (R6G), lissamine rhodamine B sulfonyl chloride, rhodamine (Rhod), rhodamine B, rhodamine 123, rhodamine X isothiocyanate, rhodamine green, sulforhodamine B, sulforhodamine 101 and sulfonyl chloride derivative of sulforhodamine 101 (Texas Red); N,N,N',N'-tetramethyl-6-carboxyrhodamine (TAMRA); tetramethyl rhodamine; tetramethyl rhodamine isothiocyanate (TRITC); riboflavin; rosolic acid and terbium chelate derivatives. Other suitable fluorophores include thiol-reactive europium chelates which emit at approximately 617 mn (Heyduk and Heyduk, Analyt. Biochem. 248:216-27, 1997; J. Biol. Chem. 274:3315-22, 1999), as well as GFP, LissamineTM, diethylaminocoumarin, fluorescein chlorotriazinyl, naphthofiuorescein, 4,7-dichlororhodamine and xanthene (as described in U.S. Pat. No. 5,800,996 to Lee et al.) and derivatives thereof. Other fluorophores known to those skilled in the art can also be used, for example those available from Life Technologies (Invitrogen; Molecular Probes (Eugene, Oreg.)) and including the ALEXA FLUOR® series of dyes (for example, as described in U.S. Pat. Nos. 5,696,157, 6, 130, 101 and 6,716,979), the BODIPY series of dyes (dipyrrometheneboron difluoride dyes, for example as described in U.S. Pat. Nos. 4,774,339, 5,187,288, 5,248,782, 5,274,113, 5,338,854, 5,451,663 and 5,433,896), Cascade Blue (an amine reactive derivative of the sulfonated pyrene described in U.S. Pat. No. 5,132,432) and Marina Blue (U.S. Pat. No. 5,830,912).

In addition to the fiuorochromes described above, a fluorescent label can be a fluorescent nanoparticle, such as a semiconductor nanocrystal, e.g., a QUANTUM DOTTM (obtained, for example, from Life Technologies (QuantumDot Corp, Invitrogen Nanocrystal Technologies, Eugene, Oreg.); see also, U.S. Pat. Nos. 6,815,064; 6,682,596; and 6,649, 138). Semiconductor nanocrystals are microscopic particles having size-dependent optical and/or electrical properties. When semiconductor nanocrystals are illuminated with a primary energy source, a secondary emission of energy occurs of a frequency that corresponds to the handgap of the semiconductor material used in the semiconductor nanocrystal. This emission can he detected as colored light of a specific wavelength or fluorescence. Semiconductor nanocrystals with different spectral characteristics are described in e.g., U.S. Pat. No. 6,602,671. Semiconductor nanocrystals that can he coupled to a variety of biological molecules (including dNTPs and/or nucleic acids) or substrates by techniques described in, for example, Bruchez et al, Science 281 :20132016, 1998; Chan et al, Science 281 :2016-2018, 1998; and U.S. Pat. No. 6,274,323. Formation of semiconductor nanocrystals of various compositions are disclosed in, e.g., U.S. Pat. Nos. 6,927, 069; 6,914,256; 6,855,202; 6,709,929; 6,689,338; 6,500,622; 6,306,736; 6,225,198; 6,207,392; 6,114,038; 6,048,616; 5,990,479; 5,690,807; 5,571,018; 5,505,928; 5,262,357 and in U.S. Patent Publication No. 2003/0165951 as well as PCT Publication No. 99/26299 (puhlished May 27, 1999). Separate populations of semiconductor nanocrystals can he produced that are identifiable based on their different spectral characteristics. For example, semiconductor nanocrystals can he produced that emit light of different colors hased on their composition, size or size and composition. For example, quantum dots that emit light at different wavelengths based on size (565 mn, 655 mn, 705 mn, or 800 mn emission wavelengths), which are suitable as fluorescent labels in the probes disclosed herein are available from Life Technologies (Carlshad, Calif).

Additional labels include, for example, radioisotopes (such as 3 H), metal chelates such as DOTA and DPTA chelates of radioactive or paramagnetic metal ions like Gd3+, and liposomes.

Detectable labels that can he used with nucleic acid molecules also include enzymes, for example horseradish peroxidase, alkaline phosphatase, acid phosphatase, glucose oxidase, beta-galactosidase, beta-glucuronidase, or beta-lactamase.

Alternatively, an enzyme can he used in a metallographic detection scheme. For example, silver in situ hyhridization (SISH) procedures involve metallographic detection schemes for identification and localization of a hybridized genomic target nucleic acid sequence. Metallographic detection methods include using an enzyme, such as alkaline phosphatase, in combination with a water-soluble metal ion and a redox-inactive substrate of the enzyme. The substrate is converted to a redox-active agent by the enzyme, and the redoxactive agent reduces the metal ion, causing it to form a detectable precipitate. (See, for example, U.S. Patent Application Publication No. 2005/0100976, PCT Publication No. 2005/ 003777 and U.S. Patent Application Publication No. 2004/ 0265922). Metallographic detection methods also include using an oxido-reductase enzyme (such as horseradish peroxidase) along with a water soluble metal ion, an oxidizing agent and a reducing agent, again to form a detectable precipitate. (See, for example, U.S. Pat. No. 6,670,113).

Probes made using the disclosed methods can be used for nucleic acid detection, such as ISH procedures (for example, fluorescence in situ hybridization (FISH), chromogenic in situ hybridization (CISH) and silver in situ hybridization (SISH)) or comparative genomic hybridization (CGH).

In situ hybridization (ISH) involves contacting a sample containing target nucleic acid sequence (e.g., genomic target nucleic acid sequence) in the context of a metaphase or interphase chromosome preparation (such as a cell or tissue sample mounted on a slide) with a labeled probe specifically hybridizable or specific for the target nucleic acid sequence (e.g., genomic target nucleic acid sequence). The slides are optionally pretreated, e.g., to remove paraffin or other materials that can interfere with uniform hybridization. The sample and the probe are both treated, for example by heating to denature the double stranded nucleic acids. The probe (formulated in a suitable hybridization buffer) and the sample are combined, under conditions and for sufficient time to permit hybridization to occur (typically to reach equilibrium). The chromosome preparation is washed to remove excess probe, and detection of specific labeling of the chromosome target is performed using standard techniques.

For example, a biotinylated probe can be detected using fluorescein-labeled avidin or avidin-alkaline phosphatase. For fluorochrome detection, the fluorochrome can be detected directly, or the samples can be incubated, for example, with fluorescein isothiocyanate (FITC)- conjugated avidin. Amplification of the FITC signal can be effected, if necessary, by incubation with biotin-conjugated goat antiavidin antibodies, washing and a second incubation with FITC- conjugated avidin. For detection by enzyme activity, samples can be incubated, for example, with streptavidin, washed, incubated with biotin-conjugated alkaline phosphatase, washed again and pre-equilibrated (e.g., in alkaline phosphatase (AP) buffer). For a general description of in situ hybridization procedures, see, e.g., U.S. Pat. No. 4,888,278.

Numerous procedures for FISH, CISH, and SISH are known in the art. For example, procedures for performing FISH are described in U.S. Pat. Nos. 5,447,841; 5,472,842; and 5,427,932; and for example, in Pirlkel et al, Proc. Natl. Acad. Sci. 83:2934-2938, 1986; Pinkel et al, Proc. Natl. Acad. Sci. 85:9138-9142, 1988; and Lichter et al, Proc. Natl. Acad. Sci. 85:9664-9668, 1988. CISH is described in, e.g., Tanner et al, Am. .1. Pathol. 157: 1467-1472, 2000 and U.S. Pat. No. 6,942,970. Additional detection methods are provided in U.S. Pat. No. 6,280,929.

Numerous reagents and detection schemes can be employed in conjunction with FISH, CISH, and SISH procedures to improve sensitivity, resolution, or other desirable properties. As discussed above probes labeled with fluorophores (including fluorescent dyes and QUANTUM DOTS®) can be directly optically detected when performing FISH. Alternatively, the probe can be labeled with a nonfluorescent molecule, such as a hapten (such as the following non- limiting examples: biotin, digoxigenin, DNP, and various oxazoles, pyrrazoles, thiazoles, nitroaryls, benzofurazans, triterpenes, ureas, thioureas, rotenones, coumarin, courmarin-based compounds, Podophyllotoxin, Podophyllotoxin-based compounds, and combinations thereof), ligand or other indirectly detectable moiety. Probes labeled with such non-fluorescent molecules (and the target nucleic acid sequences to which they bind) can then be detected by contacting the sample (e.g., the cell or tissue sample to which the probe is bound) with a labeled detection reagent, such as an antibody (or receptor, or other specific binding partner) specific for the chosen hapten or ligand. The detection reagent can be labeled with a fluorophore (e.g., QUANTUM DOT®) or with another indirectly detectable moiety, or can be contacted with one or more additional specific binding agents (e.g., secondary or specific antibodies), which can be labeled with a fluorophore.

In other examples, the probe, or specific binding agent (such as an antibody, e.g., a primary antibody, receptor or other binding agent) is labeled with an enzyme that is capable of converting a fluorogenic or chromogenic composition into a detectable fluorescent, colored or otherwise detectable signal (e.g., as in deposition of detectable metal particles in SISH). As indicated above, the enzyme can be attached directly or indirectly via a linker to the relevant probe or detection reagent. Examples of suitable reagents (e.g., binding reagents) and chemistries (e.g., linker and attachment chemistries) are described in U.S. Patent Application Publication Nos. 2006/0246524; 2006/0246523, and 2007/ 01 17153.

It will he appreciated by those of skill in the art that by appropriately selecting labelled probe-specific binding agent pairs, multiplex detection schemes can he produced to facilitate detection of multiple target nucleic acid sequences (e.g., genomic target nucleic acid sequences) in a single assay (e.g., on a single cell or tissue sample or on more than one cell or tissue sample). For example, a first probe that corresponds to a first target sequence can he labelled with a first hapten, such as biotin, while a second probe that corresponds to a second target sequence can be labelled with a second hapten, such as DNP. Following exposure of the sample to the probes, the bound probes can he detected by contacting the sample with a first specific binding agent (in this case avidin labelled with a first fluorophore, for example, a first spectrally distinct QUANTUM DOT®, e.g., that emits at 585 mn) and a second specific binding agent (in this case an anti-DNP antibody, or antibody fragment, labelled with a second fluorophore (for example, a second spectrally distinct QUANTUM DOT®, e.g., that emits at 705 mn). Additional probes/binding agent pairs can he added to the multiplex detection scheme using other spectrally distinct fluorophores. Numerous variations of direct, and indirect (one step, two step or more) can he envisioned, all of which are suitable in the context of the disclosed probes and assays.

Probes typically comprise single-stranded nucleic acids of between 10 to 1000 nucleotides in length, for instance of between 10 and 800, more preferably of between 15 and 700, typically of between 20 and 500. Primers typically are shorter single-stranded nucleic acids, of between 10 to 25 nucleotides in length, designed to perfectly or almost perfectly match a nucleic acid of interest, to be amplified. The probes and primers are "specific" to the nucleic acids they hybridize to, i.e. they preferably hybridize under high stringency hybridization conditions (corresponding to the highest melting temperature Tm, e.g., 50 % formamide, 5x or 6x SCC. SCC is a 0.15 M NaCl, 0.015 M Na-citrate). The nucleic acid primers or probes used in the above amplification and detection method may be assembled as a kit. Such a kit includes consensus primers and molecular probes. A preferred kit also includes the components necessary to determine if amplification has occurred. The kit may also include, for example, PCR buffers and enzymes; positive control sequences, reaction control primers; and instructions for amplifying and detecting the specific sequences. In some embodiments, the methods of the invention comprise the steps of providing total RNAs extracted from cumulus cells and subjecting the RNAs to amplification and hybridization to specific probes, more particularly by means of a quantitative or semi- quantitative RT-PCR.

In some embodiments, the level is determined by DNA chip analysis. Such DNA chip or nucleic acid microarray consists of different nucleic acid probes that are chemically attached to a substrate, which can be a microchip, a glass slide or a microsphere-sized bead. A microchip may be constituted of polymers, plastics, resins, polysaccharides, silica or silica-based materials, carbon, metals, inorganic glasses, or nitrocellulose. Probes comprise nucleic acids such as cDNAs or oligonucleotides that may be about 10 to about 60 base pairs. To determine the level, a sample from a test subject, optionally first subjected to a reverse transcription, is labelled and contacted with the microarray in hybridization conditions, leading to the formation of complexes between target nucleic acids that are complementary to probe sequences attached to the microarray surface. The labelled hybridized complexes are then detected and can be quantified or semi-quantified. Labelling may be achieved by various methods, e.g. by using radioactive or fluorescent labelling. Many variants of the microarray hybridization technology are available to the man skilled in the art (see e.g. the review by Hoheisel, Nature Reviews, Genetics, 2006, 7:200-210).

In some embodiments, the nCounter® Analysis system is used to detect intrinsic gene expression. The basis of the nCounter® Analysis system is the unique code assigned to each nucleic acid target to be assayed (International Patent Application Publication No. WO 08/124847, U.S. Patent No. 8,415,102 and Geiss et al. Nature Biotechnology. 2008. 26(3): 317- 325; the contents of which are each incorporated herein by reference in their entireties). The code is composed of an ordered series of colored fluorescent spots which create a unique barcode for each target to be assayed. A pair of probes is designed for each DNA or RNA target, a biotinylated capture probe and a reporter probe carrying the fluorescent barcode. This system is also referred to, herein, as the nanoreporter code system. Specific reporter and capture probes are synthesized for each target. The reporter probe can comprise at a least a first label attachment region to which are attached one or more label monomers that emit light constituting a first signal; at least a second label attachment region, which is non-over-lapping with the first label attachment region, to which are attached one or more label monomers that emit light constituting a second signal; and a first target- specific sequence. Preferably, each sequence specific reporter probe comprises a target specific sequence capable of hybridizing to no more than one gene and optionally comprises at least three, or at least four label attachment regions, said attachment regions comprising one or more label monomers that emit light, constituting at least a third signal, or at least a fourth signal, respectively. The capture probe can comprise a second target-specific sequence; and a first affinity tag. In some embodiments, the capture probe can also comprise one or more label attachment regions. Preferably, the first target- specific sequence of the reporter probe and the second target- specific sequence of the capture probe hybridize to different regions of the same gene to be detected. Reporter and capture probes are all pooled into a single hybridization mixture, the "probe library". The relative abundance of each target is measured in a single multiplexed hybridization reaction. The method comprises contacting the tumor tissue sample with a probe library, such that the presence of the target in the sample creates a probe pair - target complex. The complex is then purified. More specifically, the sample is combined with the probe library, and hybridization occurs in solution. After hybridization, the tripartite hybridized complexes (probe pairs and target) are purified in a two-step procedure using magnetic beads linked to oligonucleotides complementary to universal sequences present on the capture and reporter probes. This dual purification process allows the hybridization reaction to be driven to completion with a large excess of target-specific probes, as they are ultimately removed, and, thus, do not interfere with binding and imaging of the sample. All post hybridization steps are handled robotically on a custom liquid-handling robot (Prep Station, NanoString Technologies). Purified reactions are typically deposited by the Prep Station into individual flow cells of a sample cartridge, bound to a streptavidin-coated surface via the capture probe,electrophoresed to elongate the reporter probes, and immobilized. After processing, the sample cartridge is transferred to a fully automated imaging and data collection device (Digital Analyzer, NanoString Technologies). The level of a target is measured by imaging each sample and counting the number of times the code for that target is detected. For each sample, typically 600 fields-of-view (FOV) are imaged (1376 X 1024 pixels) representing approximately 10 mm2 of the binding surface. Typical imaging density is 100- 1200 counted reporters per field of view depending on the degree of multiplexing, the amount of sample input, and overall target abundance. Data is output in simple spreadsheet format listing the number of counts per target, per sample. This system can be used along with nanoreporters. Additional disclosure regarding nanoreporters can be found in International Publication No. WO 07/076129 and WO07/076132, and US Patent Publication No. 2010/0015607 and 2010/0261026, the contents of which are incorporated herein in their entireties. Further, the term nucleic acid probes and nanoreporters can include the rationally designed (e.g. synthetic sequences) described in International Publication No. WO 2010/019826 and US Patent Publication No.2010/0047924, incorporated herein by reference in its entirety.

Expression level of a gene may be expressed as absolute level or normalized level. Typically, levels are normalized by correcting the absolute level of a gene by comparing its expression to the expression of a gene that is not a relevant for determining the cancer stage of the subject, e.g., a housekeeping gene that is constitutively expressed. Suitable genes for normalization include housekeeping genes such as the actin gene ACTB, ribosomal 18S gene, GUSB, PGK1 and TFRC. This normalization allows the comparison of the level in one sample, e.g., a subject sample, to another sample, or between samples from different sources.

In some embodiments, the method of the present invention comprises comparing the determined expression level with a panel of predetermined reference values that correlate with the quantity of the population of neutrophils determined in a reference tissue sample.

According to the present invention, the predetermined references values are determined from reference samples wherein the expression level of the gene(s) was (were) determined and adjusted with the exact quantification of the population of cells. Typically, a set of reference samples characterized using both gene expression and another measurement technique such as immunohistochemistry, flow cytometry, or RNA can be used for defining the panel of the predetermined reference value. Mixtures of known cellular proportions also can be suitable for determining the predetermined reference values.

The method of the present invention is particularly suitable for determining the proportion of the population of neutrophils in the tissue sample. Typically, when at least one further population of cells is quantified as above described the proportion is determined by any well-known method in the art that typically involves use of algorithm based e.g. on regression models.

The method of the present invention is thus suitable for characterizing the immune, endothelial and fibroblastic components of the microenvironment of a tumor to decipher interactions between these cell types that can impact the progression of the tumor and eventually the subject's survival time. The method of the present invention is thus particularly suitable for determining the survival time of a subject suffering from a cancer. The method is thus particularly suitable for predicting the duration of the overall survival (OS), progression-free survival (PFS) and/or the disease-free survival (DFS) of the cancer subject. Those of skill in the art will recognize that OS survival time is generally based on and expressed as the percentage of people who survive a certain type of cancer for a specific amount of time. Cancer statistics often use an overall five-year survival rate. In general, OS rates do not specify whether cancer survivors are still undergoing treatment at five years or if they've become cancer-free (achieved remission). DSF gives more specific information and is the number of people with a particular cancer who achieve remission. Also, progression-free survival (PFS) rates (the number of people who still have cancer, but their disease does not progress) includes people who may have had some success with treatment, but the cancer has not disappeared completely. As used herein, the expression "short survival time" indicates that the subject will have a survival time that will be lower than the median (or mean) observed in the general population of subjects suffering from said cancer. When the subject will have a short survival time, it is meant that the subject will have a "poor prognosis". Inversely, the expression "long survival time" indicates that the subject will have a survival time that will be higher than the median (or mean) observed in the general population of subjects suffering from said cancer. When the subject will have a long survival time, it is meant that the subject will have a "good prognosis".

The method of the present invention is also suitable for determining whether a subject suffering from a cancer is eligible or not to anti-cancer treatment. Typically, the treatment includes chemotherapy, radiotherapy, and immunotherapy. In particular, subject having a short survival time would advantageously receive an anti-cancer treatment.

As used herein, the term "treatment" or "treat" refer to both prophylactic or preventive treatment as well as curative or disease modifying treatment, including treatment of subjects at risk of contracting the disease or suspected to have contracted the disease as well as subjects who are ill or have been diagnosed as suffering from a disease or medical condition, and includes suppression of clinical relapse. The treatment may be administered to a subject having a medical disorder or who ultimately may acquire the disorder, in order to prevent, cure, delay the onset of, reduce the severity of, or ameliorate one or more symptoms of a disorder or recurring disorder, or in order to prolong the survival of a subject beyond that expected in the absence of such treatment. By "therapeutic regimen" is meant the pattern of treatment of an illness, e.g., the pattern of dosing used during therapy. A therapeutic regimen may include an induction regimen and a maintenance regimen. The phrase "induction regimen" or "induction period" refers to a therapeutic regimen (or the portion of a therapeutic regimen) that is used for the initial treatment of a disease. The general goal of an induction regimen is to provide a high level of drug to a subject during the initial period of a treatment regimen. An induction regimen may employ (in part or in whole) a "loading regimen", which may include administering a greater dose of the drug than a physician would employ during a maintenance regimen, administering a drug more frequently than a physician would administer the drug during a maintenance regimen, or both. The phrase "maintenance regimen" or "maintenance period" refers to a therapeutic regimen (or the portion of a therapeutic regimen) that is used for the maintenance of a subject during treatment of an illness, e.g., to keep the subject in remission for long periods of time (months or years). A maintenance regimen may employ continuous therapy (e.g., administering a drug at a regular intervals, e.g., weekly, monthly, yearly, etc.) or intermittent therapy (e.g., interrupted treatment, intermittent treatment, treatment at relapse, or treatment upon achievement of a particular predetermined criteria [e.g., disease manifestation, etc.]).

In some embodiments, the treatment consists of administering to the subject a chemotherapeutic agent. The term "chemotherapeutic agent" refers to chemical compounds that are effective in inhibiting tumor growth. Examples of chemotherapeutic agents include alkylating agents such as thiotepa and cyclosphosphamide; alkyl sulfonates such as busulfan, improsulfan and piposulfan; aziridines such as benzodopa, carboquone, meturedopa, and uredopa; ethylenimines and methylamelamines including altretamine, triethylenemelamine, trietylenephosphoramide, triethylenethiophosphaorarnide and trimethylolomelamine; acetogenins (especially bullatacin and bullatacinone); a carnptothecin (including the synthetic analogue topotecan); bryostatin; callystatin; CC-1065 (including its adozelesin, carzelesin and bizelesin synthetic analogues); cryptophycins (particularly cryptophycin 1 and cryptophycin 8); dolastatin; duocarmycin (including the synthetic analogues, KW-2189 and CBI-TMI); eleutherobin; pancratistatin; a sarcodictyin; spongistatin; nitrogen mustards such as chlorambucil, chlornaphazine, cholophosphamide, estrarnustine, ifosfamide, mechlorethamine, mechlorethamine oxide hydrochloride, melphalan, novembichin, phenesterine, prednimus tine, trofosfamide, uracil mustard; nitrosureas such as carmustine, chlorozotocin, fotemustine, lomustine, nimustine, ranimustine; antibiotics such as the enediyne antibiotics (e.g. calicheamicin, especially calicheamicin (11 and calicheamicin 211, see, e.g., Agnew Chem Intl. Ed. Engl. 33:183-186 (1994); dynemicin, including dynemicin A; an esperamicin; as well as neocarzinostatin chromophore and related chromoprotein enediyne antiobiotic chromomophores), aclacinomysins, actinomycin, authramycin, azaserine, bleomycins, cactinomycin, carabicin, canninomycin, carzinophilin, chromomycins, dactinomycin, daunorubicin, detorubicin, 6-diazo-5-oxo-L-norleucine, doxorubicin (including morpholino- doxorubicin, cyanomorpholino-doxorubicin, 2-pyrrolino-doxorubicin and deoxydoxorubicin), epirubicin, esorubicin, idanrbicin, marcellomycin, mitomycins, mycophenolic acid, nogalarnycin, olivomycins, peplomycin, potfiromycin, puromycin, quelamycin, rodorubicin, streptomgrin, streptozocin, tubercidin, ubenimex, zinostatin, zorubicin; anti-metabolites such as methotrexate and 5-fluorouracil (5-FU); folic acid analogues such as denopterin, methotrexate, pteropterin, trimetrexate; purine analogs such as fludarabine, 6-mercaptopurine, thiamiprine, thioguanine; pyrimidine analogs such as ancitabine, azacitidine, 6-azauridine, carmofur, cytarabine, dideoxyuridine, doxifluridine, enocitabine, floxuridine, 5-FU; androgens such as calusterone, dromostanolone propionate, epitiostanol, mepitiostane, testolactone; anti- adrenals such as aminoglutethimide, mitotane, trilostane; folic acid replenisher such as frolinic acid; aceglatone; aldophospharnide glycoside; aminolevulinic acid; amsacrine; bestrabucil; bisantrene; edatraxate; defofamine; demecolcine; diaziquone; elfornithine; elliptinium acetate; an epothilone; etoglucid; gallium nitrate; hydroxyurea; lentinan; lonidamine; maytansinoids such as maytansine and ansamitocins; mitoguazone; mitoxantrone; mopidamol; nitracrine; pento statin; phenamet; pirarubicin; podophyllinic acid; 2-ethylhydrazide; procarbazine; PSK®; razoxane; rhizoxin; sizofiran; spirogennanium; tenuazonic acid; triaziquone; 2,2',2"- trichlorotriethylarnine; trichothecenes (especially T-2 toxin, verracurin A, roridinA and anguidine); urethan; vindesine; dacarbazine; mannomustine; mitobromtol; mitolactol; pipobroman; gacytosine; arabinoside ("Ara-C"); cyclophosphamide; thiotepa; taxoids, e.g. paclitaxel (TAXOL®, Bristol-Myers Squibb Oncology, Princeton, N.].) and doxetaxel (TAXOTERE®, Rhone -Poulenc Rorer, Antony, France); chlorambucil; gemcitabine; 6- thioguanine; mercaptopurine; methotrexate; platinum analogs such as cisplatin and carboplatin; vinblastine; platinum; etoposide (VP- 16); ifosfamide; mitomycin C; mitoxantrone; vincristine; vinorelbine; navelbine; novantrone; teniposide; daunomycin; aminopterin; xeloda; ibandronate; CPT-1 1 ; topoisomerase inhibitor RFS 2000; difluoromethylornithine (DMFO); retinoic acid; capecitabine; and phannaceutically acceptable salts, acids or derivatives of any of the above. Also included in this definition are antihormonal agents that act to regulate or inhibit honnone action on tumors such as anti-estrogens including for example tamoxifen, raloxifene, aromatase inhibiting 4(5)-imidazoles, 4-hydroxytamoxifen, trioxifene, keoxifene, LY 117018, onapristone, and toremifene (Fareston); and anti-androgens such as flutamide, nilutamide, bicalutamide, leuprolide, and goserelin; and phannaceutically acceptable salts, acids or derivatives of any of the above. In some embodiments, the treatment consists of administering to the subject a targeted cancer therapy. Targeted cancer therapies are drugs or other substances that block the growth and spread of cancer by interfering with specific molecules ("molecular targets") that are involved in the growth, progression, and spread of cancer. Targeted cancer therapies are sometimes called "molecularly targeted drugs," "molecularly targeted therapies," "precision medicines," or similar names. In some embodiments, the targeted therapy consists of administering the subject with a tyrosine kinase inhibitor. The term "tyrosine kinase inhibitor" refers to any of a variety of therapeutic agents or drugs that act as selective or non-selective inhibitors of receptor and/or non-receptor tyrosine kinases. Tyrosine kinase inhibitors and related compounds are well known in the art and described in U.S Patent Publication 2007/0254295, which is incorporated by reference herein in its entirety. It will be appreciated by one of skill in the art that a compound related to a tyrosine kinase inhibitor will recapitulate the effect of the tyrosine kinase inhibitor, e.g., the related compound will act on a different member of the tyrosine kinase signaling pathway to produce the same effect as would a tyrosine kinase inhibitor of that tyrosine kinase. Examples of tyrosine kinase inhibitors and related compounds suitable for use in methods of embodiments of the present invention include, but are not limited to, dasatinib (BMS-354825), PP2, BEZ235, saracatinib, gefitinib (Iressa), sunitinib (Sutent; SU11248), erlotinib (Tarceva; OSI-1774), lapatinib (GW572016; GW2016), canertinib (CI 1033), semaxinib (SU5416), vatalanib (PTK787/ZK222584), sorafenib (BAY 43-9006), imatinib (Gleevec; STI571), leflunomide (SU101), vandetanib (Zactima; ZD6474), MK-2206 (8-[4-aminocyclobutyl)phenyl]-9-phenyl-l,2,4-triazolo[3,4-f][l,6]naphthyridin- 3(2H)-one hydrochloride) derivatives thereof, analogs thereof, and combinations thereof. Additional tyrosine kinase inhibitors and related compounds suitable for use in the present invention are described in, for example, U.S Patent Publication 2007/0254295, U.S. Pat. Nos. 5,618,829, 5,639,757, 5,728,868, 5,804,396, 6,100,254, 6,127,374, 6,245,759, 6,306,874, 6,313,138, 6,316,444, 6,329,380, 6,344,459, 6,420,382, 6,479,512, 6,498,165, 6,544,988, 6,562,818, 6,586,423, 6,586,424, 6,740,665, 6,794,393, 6,875,767, 6,927,293, and 6,958,340, all of which are incorporated by reference herein in their entirety. In certain embodiments, the tyrosine kinase inhibitor is a small molecule kinase inhibitor that has been orally administered and that has been the subject of at least one Phase I clinical trial, more preferably at least one Phase II clinical, even more preferably at least one Phase III clinical trial, and most preferably approved by the FDA for at least one hematological or oncological indication. Examples of such inhibitors include, but are not limited to, Gefitinib, Erlotinib, Lapatinib, Canertinib, BMS- 599626 (AC-480), Neratinib, KR -633, CEP-11981, Imatinib, Nilotinib, Dasatinib, AZM- 475271, CP-724714, TAK-165, Sunitinib, Vatalanib, CP-547632, Vandetanib, Bosutinib, Lestaurtinib, Tandutinib, Midostaurin, Enzastaurin, AEE-788, Pazopanib, Axitinib, Motasenib, OSI-930, Cediranib, KR -951, Dovitinib, Seliciclib, SNS-032, PD-0332991, MKC-I (Ro- 317453; R-440), Sorafenib, ABT-869, Brivanib (BMS-582664), SU-14813, Telatinib, SU- 6668, (TSU-68), L-21649, MLN-8054, AEW-541, and PD-0325901.

In some embodiments, the treatment consists of administering to the subject an anti- VEGF agent. As used herein an "anti-VEGF agent" refers to a molecule that inhibits VEGF - mediated angiogenesis, vasculogenesis, or undesirable vascular permeability. For example, an anti-VEGF therapeutic may be an antibody to or other antagonist of VEGF. An "anti-VEGF antibody" is an antibody that binds to VEGF with sufficient affinity and specificity to be useful in a method of the invention. An anti-VEGF antibody will usually not bind to other VEGF homologues such as VEGF- B or VEGF-C, or other growth factors such as P1GF, PDGF or bFGF. A preferred anti- VEGF antibody is a monoclonal antibody that binds to the same epitope as the monoclonal anti-VEGF antibody A4.6.1 produced by hybridoma ATCC® HB 10709 and is a high-affinity anti-VEGF antibody. A "high-affinity anti-VEGF antibody" has at least 10- fold better affinity for VEGF than the monoclonal anti-VEGF antibody A4.6.1. Preferably the anti-VEGF antibody is a recombinant humanized anti-VEGF monoclonal antibody fragment generated according to WO 98/45331, including an antibody comprising the CDRs or the variable regions of Y0317. More preferably, anti-VEGF antibody is the antibody fragment known as ranibizumab (LUCENTIS ®). The anti-VEGF antibody ranibizumab is a humanized, affinity-matured anti-human VEGF Fab fragment. Ranibizumab is produced by standard recombinant technology methods in E. coli expression vector and bacterial fermentation. Ranibizumab is not glycosylated and has a molecular mass of -48,000 daltons. See W098/45331 and U.S. 2003/0190317. Anti-VEGF agents include but are not limited to bevacizumab (rhuMab VEGF, Avastin®, Genentech, South San Francisco Calif), ranibizumab (rhuFAb V2, Lucentis®, Genentech), pegaptanib (Macugen®, Eyetech Pharmaceuticals, New York N.Y.), sunitinib maleate (Sutent®, Pfizer, Groton Conn.) In some embodiments, the treatment consists of administering to the subject an immunotherapeutic agent. The term "immunotherapeutic agent," as used herein, refers to a compound, composition or treatment that indirectly or directly enhances, stimulates or increases the body's immune response against cancer cells and/or that decreases the side effects of other anticancer therapies. Immunotherapy is thus a therapy that directly or indirectly stimulates or enhances the immune system's responses to cancer cells and/or lessens the side effects that may have been caused by other anti-cancer agents. Immunotherapy is also referred to in the art as immunologic therapy, biological therapy biological response modifier therapy and biotherapy. Examples of common immunotherapeutic agents known in the art include, but are not limited to, cytokines, cancer vaccines, monoclonal antibodies and non-cytokine adjuvants. Alternatively the immunotherapeutic treatment may consist of administering the subject with an amount of immune cells (T cells, NK, cells, dendritic cells, B cells...).

Immunotherapeutic agents can be non-specific, i.e. boost the immune system generally so that the human body becomes more effective in fighting the growth and/or spread of cancer cells, or they can be specific, i.e. targeted to the cancer cells themselves immunotherapy regimens may combine the use of non-specific and specific immunotherapeutic agents.

Non-specific immunotherapeutic agents are substances that stimulate or indirectly improve the immune system. Non-specific immunotherapeutic agents have been used alone as a main therapy for the treatment of cancer, as well as in addition to a main therapy, in which case the non-specific immunotherapeutic agent functions as an adjuvant to enhance the effectiveness of other therapies (e.g. cancer vaccines). Non-specific immunotherapeutic agents can also function in this latter context to reduce the side effects of other therapies, for example, bone marrow suppression induced by certain chemotherapeutic agents. Non-specific immunotherapeutic agents can act on key immune system cells and cause secondary responses, such as increased production of cytokines and immunoglobulins. Alternatively, the agents can themselves comprise cytokines. Non-specific immunotherapeutic agents are generally classified as cytokines or non-cytokine adjuvants.

A number of cytokines have found application in the treatment of cancer either as general non-specific immunotherapies designed to boost the immune system, or as adjuvants provided with other therapies. Suitable cytokines include, but are not limited to, interferons, interleukins and colony-stimulating factors. Interferons (IFNs) contemplated by the present invention include the common types of IFNs, IFN-alpha (IFN-a), IFN-beta (IFN-β) and IFN-gamma (IFN-γ). IFNs can act directly on cancer cells, for example, by slowing their growth, promoting their development into cells with more normal behaviour and/or increasing their production of antigens thus making the cancer cells easier for the immune system to recognise and destroy. IFNs can also act indirectly on cancer cells, for example, by slowing down angiogenesis, boosting the immune system and/or stimulating natural killer (NK) cells, T cells and macrophages. Recombinant IFN-alpha is available commercially as Roferon (Roche Pharmaceuticals) and Intron A (Schering Corporation).

Interleukins contemplated by the present invention include IL-2, IL-4, IL-11 and IL-12. Examples of commercially available recombinant interleukins include Proleukin® (IL-2; Chiron Corporation) and Neumega® (IL-12; Wyeth Pharmaceuticals). Zymogenetics, Inc. (Seattle, Wash.) is currently testing a recombinant form of IL-21, which is also contemplated for use in the combinations of the present invention.

Colony- stimulating factors (CSFs) contemplated by the present invention include granulocyte colony stimulating factor (G-CSF or filgrastim), granulocyte-macrophage colony stimulating factor (GM-CSF or sargramostim) and erythropoietin (epoetin alfa, darbepoietin). Treatment with one or more growth factors can help to stimulate the generation of new blood cells in subjects undergoing traditional chemotherapy. Accordingly, treatment with CSFs can be helpful in decreasing the side effects associated with chemotherapy and can allow for higher doses of chemotherapeutic agents to be used. Various-recombinant colony stimulating factors are available commercially, for example, Neupogen® (G-CSF; Amgen), Neulasta (pelfilgrastim; Amgen), Leukine (GM-CSF; Berlex), Procrit (erythropoietin; Ortho Biotech), Epogen (erythropoietin; Amgen), Arnesp (erytropoietin).

In addition to having specific or non-specific targets, immunotherapeutic agents can be active, i.e. stimulate the body's own immune response, or they can be passive, i.e. comprise immune system components that were generated external to the body.

Passive specific immunotherapy typically involves the use of one or more monoclonal antibodies that are specific for a particular antigen found on the surface of a cancer cell or that are specific for a particular cell growth factor. Monoclonal antibodies may be used in the treatment of cancer in a number of ways, for example, to enhance a subject's immune response to a specific type of cancer, to interfere with the growth of cancer cells by targeting specific cell growth factors, such as those involved in angiogenesis, or by enhancing the delivery of other anticancer agents to cancer cells when linked or conjugated to agents such as chemotherapeutic agents, radioactive particles or toxins.

In some embodiments, the immunotherapeutic agent is an immune checkpoint inhibitor. As used herein, the term "immune checkpoint inhibitor" refers to molecules that totally or partially reduce, inhibit, interfere with or modulate one or more checkpoint proteins. Checkpoint proteins regulate T-cell activation or function. Numerous checkpoint proteins are known, such as CTLA-4 and its ligands CD 80 and CD86; and PDl with its ligands PDLl and PDL2 (Pardoll, Nature Reviews Cancer 12: 252-264, 2012). These proteins are responsible for co-stimulatory or inhibitory interactions of T-cell responses. Immune checkpoint proteins regulate and maintain self-tolerance and the duration and amplitude of physiological immune responses. Immune checkpoint inhibitors include antibodies or are derived from antibodies. In some embodiments, the immune checkpoint inhibitor is an antibody selected from the group consisting of anti-CTLA4 antibodies (e.g. Ipilimumab), anti-PDl antibodies, anti-PDLl antibodies, anti-TIMP3 antibodies, anti-LAG3 antibodies, anti-B7H3 antibodies, anti-B7H4 antibodies, anti-BTLA antibodies, and anti-B7H6 antibodies. Examples of anti-CTLA-4 antibodies are described in US Patent Nos: 5,811,097; 5,811,097; 5,855,887; 6,051,227; 6,207,157; 6,682,736; 6,984,720; and 7,605,238. One anti-CDLA-4 antibody is tremelimumab, (ticilimumab, CP-675,206). In some embodiments, the anti-CTLA-4 antibody is ipilimumab (also known as 10D1, MDX-D010) a fully human monoclonal IgG antibody that binds to CTLA-4. Another immune checkpoint protein is programmed cell death 1 (PD-1). Examples of PD-1 and PD-11 blockers are described in US Patent Nos. 7,488,802; 7,943,743; 8,008,449; 8,168,757; 8,217,149, and PCT Published Patent Application Nos: WO03042402, WO2008156712, WO2010089411, WO2010036959, WO2011066342, WO2011159877, WO2011082400, and WO2011161699. In some embodiments, the PD-1 blockers include anti- PD-L1 antibodies. In certain other embodiments the PD-1 blockers include anti-PD-1 antibodies and similar binding proteins such as nivolumab (MDX 1106, BMS 936558, ONO 4538), a fully human IgG4 antibody that binds to and blocks the activation of PD-1 by its ligands PD-L1 and PD-L2; lambrolizumab (MK-3475 or SCH 900475), a humanized monoclonal IgG4 antibody against PD-1 ; CT-011 a humanized antibody that binds PD-1 ; AMP-224 is a fusion protein of B7-DC; an antibody Fc portion; BMS-936559 (MDX- 1105-01) for PD-L1 (B7-H1) blockade. Other immune-checkpoint inhibitors include lymphocyte activation gene-3 (LAG-3) inhibitors, such as IMP321, a soluble Ig fusion protein (Brignone et al, 2007, J. Immunol. 179:4202- 4211). Other immune-checkpoint inhibitors include B7 inhibitors, such as B7-H3 and B7-H4 inhibitors. In particular, the anti-B7-H3 antibody MGA271 (Loo et al., 2012, Clin. Cancer Res. July 15 (18) 3834). Also included are TIM3 (T-cell immunoglobulin domain and mucin domain 3) inhibitors (Fourcade et al, 2010, J. Exp. Med. 207:2175-86 and Sakuishi et al, 2010, J. Exp. Med. 207:2187-94).

In some embodiments, the immunotherapeutic treatment consists of an adoptive immunotherapy as described by Nicholas P. Restifo, Mark E. Dudley and Steven A. Rosenberg "Adoptive immunotherapy for cancer: harnessing the T cell response, Nature Reviews Immunology, Volume 12, April 2012). In adoptive immunotherapy, the patient's circulating lymphocytes, or tumor infiltrated lymphocytes, are isolated in vitro, activated by lymphokines such as IL-2 and readministered (Rosenberg et al, 1988; 1989). The activated lymphocytes are most preferably be the patient's own cells that were earlier isolated from a blood sampke and activated (or "expanded") in vitro. In some embodiments, the subject is administered with host cells that express a chimeric antigen receptor. As used herein, the term "chimeric antigen receptor" or "CAR" has its general meaning in the art and refers to an artificially constructed hybrid protein or polypeptide containing the antigen binding domains of an antibody (e.g., scFv) linked to T- cell signaling domains. Characteristics of CARs include their ability to redirect T- cell specificity and reactivity toward a selected target in a non-MHC -restricted manner, exploiting the antigen-binding properties of monoclonal antibodies. The non-MHC-restricted antigen recognition gives T cells expressing CARs the ability to recognize antigen independent of antigen processing, thus bypassing a major mechanism of tumor escape. Moreover, when expressed in T-cells, CARs advantageously do not dimerize with endogenous T cell receptor (TCR) alpha and beta chains. While the host cell can be of any cell type, can originate from any type of tissue, and can be of any developmental stage, the host cell is a T cell, e.g. isolated from peripheral blood lymphocytes (PBL) or peripheral blood mononuclear cells (PBMC). In some embodiments, the T cell can be any T cell, such as a cultured T cell, e.g., a primary T cell, or a T cell from a cultured T cell line, e.g., Jurkat, SupTl, etc., or a T cell obtained from a mammal. If obtained from a mammal, the T cell can be obtained from numerous sources, including but not limited to blood, bone marrow, lymph node, the thymus, or other tissues or fluids. T cells can also be enriched for or purified. The T cell can be any type of T cell and can be of any developmental stage, including but not limited to, CD4+/CD8+ double positive T cells, CD4+ helper T cells, e.g., Th2 cells, CD8+ T cells (e.g., cytotoxic T cells), tumor infiltrating cells, memory T cells, naive T cells, and the like. The T cell may be a CD8+ T cell or a CD4+ T cell. The population of those T cells prepared as described above can be utilized in methods and compositions for adoptive immunotherapy in accordance with known techniques, or variations thereof that will be apparent to those skilled in the art based on the instant disclosure. See, e.g., US Patent Application Publication No. 2003/0170238 to Gruenberg et al; see also US Patent No. 4,690,915 to Rosenberg. Adoptive immunotherapy of cancer refers to a therapeutic approach in which immune cells with an antitumor reactivity are administered to a tumor- bearing host, with the aim that the cells mediate either directly or indirectly, the regression of an established tumor. Transfusion of lymphocytes, particularly T lymphocytes, falls into this category. Currently, most adoptive immunotherapies are autolymphocyte therapies (ALT) directed to treatments using the patient's own immune cells. These therapies involve processing the patient's own lymphocytes to either enhance the immune cell mediated response or to recognize specific antigens or foreign substances in the body, including the cancer cells. The treatments are accomplished by removing the patient's lymphocytes and exposing these cells in vitro to biologies and drugs to activate the immune function of the cells. Once the autologous cells are activated, these ex vivo activated cells are reinfused into the patient to enhance the immune system to treat cancer. In some embodiments, the cells are formulated by first harvesting them from their culture medium, and then washing and concentrating the cells in a medium and container system suitable for administration (a "pharmaceutically acceptable" carrier) in a treatment-effective amount. Suitable infusion medium can be any isotonic medium formulation, typically normal saline, Normosol R (Abbott) or Plasma-Lyte A (Baxter), but also 5% dextrose in water or Ringer's lactate can be utilized. The infusion medium can be supplemented with human serum albumin. A treatment-effective amount of cells in the composition is dependent on the relative representation of the T cells with the desired specificity, on the age and weight of the recipient, on the severity of the targeted condition and on the immunogenicity of the targeted Ags. These amount of cells can be as low as approximately 103/kg, preferably 5xl03/kg; and as high as 107/kg, preferably 108/kg. The number of cells will depend upon the ultimate use for which the composition is intended, as will the type of cells included therein. For example, if cells that are specific for a particular Ag are desired, then the population will contain greater than 70%, generally greater than 80%, 85% and 90-95%) of such cells. For uses provided herein, the cells are generally in a volume of a liter or less, can be 500 ml or less, even 250 ml or 100 ml or less. The clinically relevant number of immune cells can be apportioned into multiple infusions that cumulatively equal or exceed the desired total amount of cells.

The immunotherapeutic treatment may consist of allografting, in particular, allograft with hematopoietic stem cell HSC. The immunotherapeutic treatment may also consist in an adoptive immunotherapy as described by Nicholas P. Restifo, Mark E. Dudley and Steven A. Rosenberg "Adoptive immunotherapy for cancer: harnessing the T cell response, Nature Reviews Immunology, Volume 12, April 2012). In adoptive immunotherapy, the subject's circulating lymphocytes, NK cells, are isolated amplified in vitro and readministered to the subject. The activated lymphocytes or NK cells are most preferably be the subject's own cells that were earlier isolated from a blood or tumor sample and activated (or "expanded") in vitro.

In some embodiments, the treatment consists of administering to the subject a radiotherapeutic agent. The term "radiotherapeutic agent" as used herein, is intended to refer to any radiotherapeutic agent known to one of skill in the art to be effective to treat or ameliorate cancer, without limitation. For instance, the radiotherapeutic agent can be an agent such as those administered in brachytherapy or radionuclide therapy. Such methods can optionally further comprise the administration of one or more additional cancer therapies, such as, but not limited to, chemotherapies, and/or another radiotherapy.

The invention will be further illustrated by the following figures and examples. However, these examples and figures should not be interpreted in any way as limiting the scope of the present invention.

EXAMPLES

Material and methods

1. Gene Expression Profiles (GEP) datasets

From public repositories, we curated transcriptomic profiles from several types of samples (Microenvironment Cell Populations (MCP), non-hematopoietic human tumors, non- diseased human tissues, in-vitro RNA mixtures) obtained from different gene expression platforms (mainly Affymetrix HGU 133 Plus 2.0, HGU 133 A, HuGene 1.0 ST and Illumina HiSeq 2000). For survival analysis, transcriptomic profiles of non-hematopoietic human tumors with Overall Survival annotations were also included. The table below lists the types of samples curated, stratified by gene expression platforms, and points to the identifiers of the included samples.

2. GEP normalization

Affymetrix Human Genome 133 Plus 2.0, Human Genome 133 A, HuGene 1.0 ST arrays MCP datasets and tumor datasets from Affymetrix Human Genome 133 Plus 2.0, Human Genome 133 A, HuGene 1.0 ST arrays were normalized using the frozen robust multiarray average (fRMA) method, implemented in the 'fRMA' R package (version 1.18.0). Unlike RMA, fRMA uses fixed estimates of probe-specific effects and variances, allowing a consistent normalization of GEP from different series, provided that they were obtained on the same gene expression platform.

GEP obtained with the Affymetrix Human Genome 133 Plus 2.0, Human Genome 133A, HuGene 1.0 ST arrays platforms were thus normalized using the 'frma' function of the 'frma' Bioconductor R package using the preprocessing input vectors provided respectively by the Bioconductor R packages 'frmahgul33plus2frmavecs' version 1.3.0, 'frmal33afrmavecs' version 1.3.0 and 'hugene.l .O.st.vlfrmavecs' version 1.0.0. The 'frma' method was called on batches of CEL files corresponding to individual series.

The Cancer Genome Atlas gene expression data

Gene expression data from non-currently-embargoed TCGA projects were obtained from the TCGA data portal (https://tcga-data.nci.nih.gov/tcga/dataAccessMatrix.htm). Only GEP obtained using Illumina HiSeq 2000 were retrieved. Already-normalized 'level 3' data were downloaded separately for each project. The resulting '*.rsem. genes .normalized results files' were then merged into a single pan-cancer expression matrix.

Other gene expression platforms

For GEP obtained using other gene expression platforms, we used pre-processed GEP data as published by each studies' authors and available from the corresponding public repositories.

3. Publicly available samples' annotations MCP datasets - Discovery serie (Ajfymetrix 133 Plus 2.0 arrays)

Samples were annotated according to the author-reported phenotypes yielding 344 distinct labels (data not shown). We recoded these labels into 63 categories, including 21 cancer cell phenotypes (42 immune and stromal labels).

MCP datasets - Validation series (Ajfymetrix 133 A and Ajfymetrix HuGene 1.0 ST arrays)

Samples were annotated according to the 63 labels used to annotate the discovery MCP series. The previously-defined 63 categories did not fit the phenotype of a few samples and motivated the addition of 15 categories (data not shown). These newly-defined categories all refine some of the initial 63 labels.

Non-diseased human tissues (GEO:GSE7307)

Samples' annotations were retrieved from GEO:GSE7307. Samples corresponding to diseased tissues, cell lines or sorted immune cells were discarded, retaining only the non- diseased cellularly-heterogeneous samples. For clarity, some tissues were regrouped in broader anatomical locations (data not shown). Anatomical systems were manually added.

Non-hematopoietic tumor samples series

From the three tumor datasets, only samples corresponding to primary tumors obtained from tumor resections with no neoadjuvant treatments and that did not use laser capture microdissection were retained for analysis (data not shown).

Annotations for samples retrieved from GEO (respectively from ArrayExpress) were retrieved from the 'Series matrix' files (respectively from 'sdrf files). Annotations for TCGA samples were retrieved from the TCGA data portal (https://tcga- data.nci.nih.gov/tcga/dataAccessMatrix.htm).

Since annotations originated from many different groups, only a subset of the variables were retained for each series. The corresponding values were harmonized into a consistent ontology. The following list contains the final set of variables for which samples' annotations were retained:

• Sample identifiers

Series identifiers

• Gene expression platform

• Cancer type Sample type (Autopsy, Biopsy, Cell culture, Surgery followed by laser capture microdissection, Surgery)

• Overall survival event and delay (months)

Non-hematopoietic tumor samples series (Other platforms)

Only sample identifiers, tumor types, sample status and Overall Survival were retained.

Removal of tumor samples duplicates

Some tumor GEP are present in multiple public datasets and correctly labeled as 'Reanalyzed'. In this case, only the original sample was considered for analysis. To avoid unspecified duplicated GEP, we computed MD5 checksums for all uncompressed CEL files. Samples with identical MD5 checksums were considered duplicates. In this case, only the sample belonging to the oldest series was kept. Annotations present on the most recent sample instance and absent from the older sample instance were added to the older sample's annotation. Conflicting annotations were resolved by keeping the oldest annotation. These conflicts never occurred for clinical follow-up variables.

4. Selection of the transcriptomic markers (TM)

Organization of the samples into a pyramidal graph of categories

We define as a pyramid a directed acyclic graph with a root node. Samples of microenvironment purified cells were labeled according to their reported immune or stromal populations, resulting in 63 distinct labels in the MCP discovery series, with an addition of 15 labels for the MCP validation series, resulting in a total of 78 labels. We organized these labels in a pyramidal graph (data not shown) with nodes representing populations (categories), and directed edges representing relations of inclusion. For instance, the labels "CD8+ T cells", "CD4+ T cells", "Τγδ cells", "Memory T cells", "Activated T cells" and "Naive T cells", and all labels included in them (for instance "Effector-memory CD8 T cells"), form the "T cells" category, which itself is included in the "T/NK lineage" category. Of these 78 labels of samples, some correspond to terminal leaves of this pyramid (ex. "Canonical CD4 Treg cells"), while some others do correspond to higher level nodes (ex. Peripheral-Blood Mononuclear Cells, "PBMC"). In addition to these 78 labels, 15 hematopoiesis or immunology-inspired categories that are not directly represented by samples but relevant for their organization in a structured pyramid (for instance "Lymphocytes") or as potential cell population (for instance "antigen- experienced B cells") were added (Supplementary Table S12). Categories corresponding to tumor samples were discarded for the identification of TM and only kept as negative controls, resulting in 68 categories available for screening.

Having defined this set of 78 labels and 68 categories (53 categories are directly represented by labels, with 15 additional categories not directly represented in the dataset), we exhaustively encoded the relationships between labels and categories using three possible relationships (data not shown). Relative to a category, we define three sets of samples:

C : 'positive samples' are those whose label is included in the category (all cells composing a sample which is in C are in the category)

C : 'negative samples' are those whose label is strictly non-overlapping with the category (all cells of a sample which is in C are not in the category)

-1 : 'mixed samples' are those whose label is partly overlapping with the category (some cells of the sample are in C and some are in C ).

For instance, for CD8+ T cells, C is the set of samples whose label is "CD8 T cells" or "Effector memory CD8 T cells" (Supplementary Figure SI, Supplementary Table SI 2), mixed samples are for instance CD3+ T cells as they mix CD4+ and CD8+ T cells, or PBMC as they mix CD8+ T cells with e.g. monocytes. C is defined as all non-positive non-mixed samples.

Hence, strict exclusion or mixture relationships are not represented but are taken into account during the screening process (data not shown).

Selection ofTMs for each category

We performed an exhaustive exploration of the categories' pyramid to screen for the existence of potential transcriptomic markers at each node. Set of positive samples are C and negative samples are C (mixed samples are discarded for this node). Given this two sets of samples, a triplet of probeset-level statistics was computed per probeset: the positive Area Under the ROC Curve (AUC), the fold-change (FC) and a specific fold-change (sFC), with the latter-two with the following definitions:

(1) FC = X - X"

(2) sFC = (X - X~ min)/(X~ max- X" min)

where we denote by X the centroid (i.e. average across all samples) of category C , X the centroid of C , X _j the centroid of any class j composing C (j= 1..k) , X min the min value across centroids of classes composing C (X _min= minj <≡ 1..k {X j} ), X max the max value across centroids of classes composing C (X _max= maxj <≡l ..k {X _j} ). The specific fold- change both accounts for a high expression in C compared to C and a low variability within

C"

For each non-root node of the pyramid, probesets with AUC>0.97, FC>2 and sFC>1.5 were retained (data not shown).

Selection of TM sets for 10 populations

Having selected in an unbiased manner the markers for each level of the pyramid, we manually selected the most relevant TM sets: we discarded

very broad categories (such as 'stromal cells' which would, in a tumor, designate all non-malignant cells from the microenvironment)

categories with too few positive samples to reliably identify robust markers from high-dimensional data

those for which no appropriate controls were represented in the discovery series those for which no markers were identified.

Reduction of TM sets for four populations

For four populations (Neutrophils, Endothelial cells, Fibroblasts and cells of the B lineage), the number of TM identified in the Discovery series was much higher (>90) than for the other cell populations (<25). To obtain more balanced marker sets, we performed the same selection process on the validation series, obtaining TM sets overlapping with those identified on the discovery series (Supplementary Table S3). To reduce the number of markers, we thus took the intersection of the markers across the three MCP series (B lineage, fibroblasts), or the discovery and the HuGene 1.OST series (Endothelial cells), or the discovery and the Affymetrix HGU 133 A series (Neutrophils). Of note, this filtering step was not performed for the figures where data from the MCP validation series were used (data not shown).

5. Computation of MCP-counter scores

Given a set of transcriptomic markers of a given category, we computed a corresponding per-sample score, called hereafter a MCP-counter score, using the log2 geometric mean of this set of markers.

6. Correlation profiles of transcriptomic markers in MCP and tumor datasets

(Supplementary Fig S5-S7) For a given set of TMs, corresponding features were subsetted from the expression matrices of the three MCP series and three primary tumor series (Affymetrix 133 Plus 2.0, 133A, and TCGA). On these six matrices, Pearson correlation coefficients were computed for each pair of features.

7. RNA mixture models

Peripheral blood immune cells sorting

Peripheral venous blood was extracted for 3 healthy donor using heparin vacuntainer tubes (BD Bioscience). Peripheral blood mononuclear (PBMC) or polymorphonuclear cells (PMN) were isolated using Ficoll-Paque PLUS (GE Healthcare Life Sience) or Polymorph Prep (Axis-Shield) density gradient, respectively. PBMCs were stained with anti-CD3 FITC (Clone UCHTl), anti-CD14 APC (ΜΦΡ9), anti-CD19 ECD (J3-119) and anti-CD56 PE (B159); and PMNs with anti-CD66b FITC (G10F5), anti-CD19 ECD (J3-119), anti-CD3 PE (UCHTl), anti- CD56 PE (B159) and anti-CD14 APC (ΜΦΡ9). Cell sorting was done in a FACS Aria cytometer (BD Bioscience), and cell purity higher than 97% was always achieved. We sorted the following populations: T cells (DAPI-/CD3+/CD14-/CD19-/CD56-), monocytes (DAPI- /CD3-/CD14+/CD19-/CD56-), B cells (DAPI-/CD3-/CD14-/CD19+/CD56-) and NK cells (DAPI-/CD3-/CD14-/CD19-/CD56+) on PBMCs, and neutrophils (DAPI-/CD66b+/CD19- /CD3-/CD56-/CD14-) on PMNs.

Cell culture

HCT116 were purchased from ATCC and cultured according to vendor's instructions.

RNA extraction

Cells were lysed in RLT (QIAGEN)- 1 % mercaptoethanol buffer, and RNA was purified with a Maxwell 16 simplyRNA Kit (Promega) according to manufacturer's instructions. Genetic material quality and quantity were determined with a 2100 Bioanalyzer Instrument (Agilent Technologies). Mixtures of RNA solutions

A set of four 2-fold serial dilutions were performed on each aliquot of RNA extracted from sorted peripheral blood immune cells, yielding solutions of decreasing concentration SO to S4 for each cell population. Ten aliquots were used to mix these solutions using two transposed latin squares layout.

The volume corresponding to ten nanograms of a solution of HCT116 colorectal-cancer cell line-extracted mRNA was then added to the Mixes 3 to 12. Two additional samples (Mixes 1 and 2) of pure HCT116 mRNA were also included.

Microarrays hybridization

Biotinylated double strand cDNA targets were prepared from 10 ng of total RNA using the NuGEN Ovation Pico WTA System V2 Kit (Cat # 3302) followed by the NuGEN Encore Biotin Module Kit (Cat # 4200) according to manufacturer recommendations. Following fragmentation and labeling, 4.55 μg of cDNAs were hybridized for 16 hours at 45°C, 60 rpm on Human GeneChip HG-U133 plus 2.0 arrays (Affymetrix). The chips were washed and stained in the GeneChip Fluidics Station 450 (Affymetrix) using the FS450 0004 script and scanned with the GeneChip Scanner 3000 7G (Affymetrix) at a resolution of 1.56 μιη. Raw data (.CEL Intensity files) were extracted from the scanned images using the Affymetrix GeneChip Command Console (AGCC) version 4.0.

Correlation between MCP-counter scores and known mRNA proportions

MCP-counter scores were computed from the fRMA-normalized RNA-mixture microarray dataset and plotted against the known mRNA log-proportions. Pearson correlation coefficients and the corresponding tests against the t distribution were performed.

Estimation of the limit of detection

For each of the five sorted cell populations (NK cells, B cells, T cells, Monocytes,

Neutrophils), we fitted a least-square linear regression model of the known mRNA log- proportions with the corresponding MCP-counter score as predictive variable using the 10 mRNA mixture samples.

The MCP-counter scores for non-hematopoietic samples from the 'MCP Discovery series' were computed. The above-described linear fits were used to predict the mRNA fraction of the five sorted cell populations from the corresponding MCP-counter scores. The exponential of the mean of the estimated log-proportions across non-hematopoietic samples is reported as the estimate of the limit of detection for each immune cell population assayed. Data deposition

The transcriptome data of the 12 mixture samples has been deposited in NCBI's Gene Expression Omnibus and are accessible through GEO Series accession number GSE64385. 8. Immunohistochemistry-based cellular densities estimates

Serial 5 um formalin-fixed paraffin-embedded (FFPE) tissue sections from colorectal cancer were stained using autostainerPlus Link 48 (Dako). Antigen retrieval and deparaffinization were carried out on a PT-Link (Dako) using the En Vision FLEX Target Retrieval Solutions (Dako). The antibodies used are listed in Supplementary Table S14. Peroxidase activity was detected using diaminobenzidine substrate (Dako). Slides stained with anti-CD3, anti-CD8A and anti-CD68 were digitalized with a NanoZoomer scanner (Hamamatsu). The densities of positive cells in the tumor core were measured using Calopix software (Tribvn, France). 9. Mapping of Affymetrix probesets to genes identifiers

For Affymetrix HGU 133 Plus 2.0, 133 A, and HuGene 1.0 ST arrays, probesets were mapped to genes identifiers using annotations provided by Affymetrix version 35.

TCGA GEP are annotated with ENTREZ identifiers which were converted to HUGO symbols using ftp://ftp.ncbi.nih.gov/gene/DATA/GENE_INFO/Mammalia/Homo_sapiens.gene_info.gz (retrieved on 2015 05 20).

10. R implementation of the MCP-counter method

We implemented MCP-counter as an R package called 'MCPcounter'. Users should call the 'MCPcounter.estimate' function, which takes a normalized gene expression matrix as its first argument, and the type of features that should be mapped to selected transcriptomic markers (probesets, HUGO symbols, ENTREZ ID) as its second argument.

We used mapped transcriptomic markers to 'probesets' to compute MCP-counter scores for 'Affymetrix 133 Plus 2.0' and 'Affymetrix 133A' samples, and HUGO symbols identifiers for samples obtained on 'Affymetrix HuGene 1.0 ST', 'Illumina Hiseq' and other gene expression platforms.

This package is available at the following URL: http://cit.hgue- cancer.net/?page_id=780&lang=en 11. Simulation of mRNA mixtures (data not shown)

Simulations were performed according to the following 5 -steps procedure: 1) For each the following five immune cell populations (T cells, NK cells, B cells, Monocytic lineage, Neutrophils), randomly choose one GEP from samples corresponding to the cell population of one of its cell subpopulations. In addition, choose a tumor cell line sample. 2) Create a vector of weights w=(0.01/5, 0.02/5, 0.05/5, 0.1/5, 0.2/5, 0.5/5, 0.9/5) corresponding to the weight of each immune population in the simulated mixture. Tumor cells are given the complementary weight l-5w. 3) For each value of w, compute a linear combination of the randomly chosen GEP with weights w for each of the five immune GEP and l-5w for tumor cells. For CIBERSORT estimates, these mixtures were computed on the linear scale and in the log2 scale for MCP-counter. 4) Add random noise drawn from the standard normal distribution to each gene expression feature of the simulated mixture. 5) Run CIBERSORT and MCP-counter algorithms on the simulated mixtures.

50 simulations were performed (leading to 350 estimates as 7 values of w per simulation run were used). Figure 4a represents, for each cell population, the mean MCP-counter scores or CIBERSORT estimates for a given value of w across the 50 simulations. For CIBERSORT, non-zero estimates of non-introduced cell populations (for instance Mast cells) were discarded, and the remaining estimates were re-normalized to sum to 1. Then, estimates for sub- populations were summed (for instance, the 'B cells' CIBERSORT estimate sums the estimates corresponding to 'B cells na'ive', 'B cells memory' and 'Plasma cells' subpopulations).

12. Comparison of MCP-counter TM sets with those from other methods (data not shown)

TM sets proposed by Bindea et al. (the "Immunome" TM set) and Yoshihara et al.

("ESTIMATE" TM set) were retrieved from the corresponding publication and the ESTIMATE R package, respectively. For the 'Immunome', probesets were used as TM for the Affymetrix 133 Plus 2.0 and 133A MCP series, and gene symbols for the HuGene 1.0 ST MCP series. For ESTIMATE, gene symbols were used for all three series. For each of the three MCP series, scores were computed (See Material and Methods, section 5) from the TM sets proposed herein, the 'Immunome' and 'ESTIMATE'. For each TM set (columns), and each cell population represented in Figure 4b (rows), the average score for the TM set in this cell population was computed. This vector of averaged score, called the 'Pred' (for prediction) vector, was linearly mapped to a color code where the minimum value was affected to blue, the maximum to red, and the mean of the maximum and the minimum to white. A 'Truce' vector of colors, formed by the status of each cell population, was appended to each 'Prediction' vector (red, i.e. positive, if the cell population is supposed to express the genes in the TM set, blue, i.e. negative if the cell population should not express genes in the TM set, and white if the cell population mixes both positive and negative cells). An accurate TM set should thus produce blue values for 'Pred' when the 'Truce' is blue, and red values when the 'Truce' is red. White values of the 'Truce' column are less informative as expression of the TM set would then depend both on the accuracy of the TM set and on the proportion of the corresponding cell population in the sample.

13. Representative MCP-counter scores across cancers (data not shown)

In each of the three tumor series, samples were split according to their tumor type. The median MCP-counter score were computed for each cell population in each tumor type, yielding three "median matrices" (one per technological platform). Since MCP-counter scores are expressed in arbitrary units which depend on the gene expression platform used, we Z- transformed each column of these three matrices (the mean of each column was substracted on each platform, and the resulting values were multiplied by the average of the three standard deviation observed across the three platform for this column) (Supplementary Figure S8). The resulting three matrices were averaged (omitting missing values in case of a cancer missing from one or two of the datasets) (data not shown).

14. Prognostic value of MCP-counter scores

For a given cancer type, several datasets, sometimes based on different platforms, were collected. MCP-counter estimates were first computed for each dataset individually. The resulting scores were then Z-transformed for each dataset individually, leading to similar distributions of the scores across datasets. Then, univariate Cox proportional hazards models for Overall Survival (OS) were fitted separately in each dataset using the related Z-transformed MCP-counter scores. To aggregate the resulting estimates (beta values) across datasets, we used the meta-analytical R package 'meta' (function 'metagen'), using a fixed-effect model (as the scores in each series follow the same distribution). This function weights the independent estimates using an inverse-variance weighting.

15. Microenvironment-based tumor classifications MCP-counter estimates were first computed for each dataset individually. The resulting scores were then Z-transformed for each dataset individually, leading to similar distributions of the scores across datasets. Datasets from the same cancer were then merged, and all MCP- counter variables were binarized using a median cut (leading to "High" and "Low" samples for each variable and for each cancer according to their relative position from the cancer's median value). We selected three tumor classifications from the literature (using B and T cells in lung adenocarcinoma, fibroblasts and cytotoxic lymphocytes in colorectal cancer, and macrophages and cytotoxic lymphocytes in breast cancer). For each of these three cancer, we concatenated the binarized scores for the two variables of interest, leading to four classes (High-High, High- Low, Low-High, Low-Low). The corresponding Kaplan-Meier curves for overall-survival were then plotted and the p-value of the corresponding log-rank test is reported.

Results: Development and validation process of the MCP-counter method

We designed a method, called MCP-counter, which objective is to measure an inter- samples relative abundance of different microenvironment cell populations. To develop and validate our method, we set up a strategy in seven steps (data not shown). MCP-counter is based on the methodological framework of transcriptomic markers (TM), defined as gene-expression features expressed in one and only one cell population, and whose expression shows little variation within the population of interest (step 1). It directly follows that within a sample composed of many different cell populations, the abundance of the population of interest is proportional to the sample's expression of its related TM. Given their restrictive definition, TM are not guaranteed to exist for all populations. We set up a Discovery series by curating Microenvironment Cell Populations (MCP) transcriptomes from 81 public datasets of 'Affymetrix_HGU_133_Plus_2.0' microarrays (step 2). These transcriptomes were normalized to allow their integration into a large meta-dataset which includes 1194 immune or non-immune microenvironment cell populations samples, and 742 non-hematopoietic tumor cell line samples as controls (Supplementary Table SI). After manual curation all the samples were annotated using 63 labels, of which 42 correspond to microenvironment cell populations and 21 represent cell lines from 21 non-hematopoietic cancer types (data not shown). We organized the 63 cell populations into a pyramidal graph according to rules of inclusions (Supplementary Figure SI). We added hematopoiesis-inspired (e.g. lymphoid and myeloid lineages) or functional (e.g. cytotoxic lymphocytes) categories to this pyramid, resulting in a total of 67 nodes corresponding to potential cellular populations of the tissue microenvironment (step 3) (data not shown). This organization was legitimated by its consistency with clusters obtained with transcriptome -based principal component analysis (step 4) (data not shown).

To identify TM of a given cell population (a node in our cell populations pyramid) (step 5), we defined as 'positive' the samples included in this population, and we defined as 'negative' the samples that do not contain this population. Samples containing both 'positive' and 'negative' cells are omitted from the analysis for this node. Three criteria were then calculated for each feature (probeset) within the Discovery set: a) the mean log2-expression difference between positive and negative samples (a threshold of 2 was applied), b) the area under the ROC curve (AUC) of the feature for the identification of the positive samples (threshold of 0.97), and c) a measure of the signal to noise ratio between positive and negative samples (threshold of 1.5) (Material and methods, Supplementary Table S2). Gene-expression features that reached the defined thresholds simultaneously for all three criteria were retained as TM for the corresponding cell population.

Since we had no a priori on the populations for which TM could be identified, we applied our selection procedure exhaustively for each non-root node of the samples' pyramid (data not shown) and selected a posteriori the most relevant TM sets. The number of identified markers at each level of this pyramidal graph is reported in Supplementary Table S3. From the 67 nodes, we retained TM for the most precise populations for which TM could be robustly identified. We thus discarded those for which appropriate 'negative' controls were not publically available (for instance, identifying TM for 'Effector Memory CD4 T cells' at least requires 'negative' controls such as 'Central Memory CD4 T cells' and 'Effector Memory CD8 T cells'), those with few 'positive' samples, or those with no identified markers after the selection procedure. Nodes corresponding to more general populations (for instance "Lymphocytes" or "Myeloid cells") were discarded as TM for more precise daughter cell populations were available. We thus retained TMs specific for 10 distinct populations: 8 immune cell populations (T cells, CD8+ T cells, NK cells, cytotoxic lymphocytes, cells of the B lineage, of the monocytic lineage, myeloid dendritic cells, and neutrophils), and 2 nonimmune stromal populations (endothelial cells and fibroblasts). The 81 datasets from the Discovery set spanned 344 different culture conditions, purifications methods and cell treatments, which ensures that the selection of TM was not sensitive to experimental conditions. MCP-counter scores were defined as the log2 average expression of the TM for each population (step 6). We then validated MCP-counter (step 7). Qualitative validation of the identified transcriptomic markers

The reproducibility of the identified TM was assessed on two validation series of 1596 samples hybridized on 'Affymetrix_U133A' arrays and 3208 samples hybridized on 'Affymetrix HuGene l .OST' arrays (data not shown). For the 10 cell populations, the specific expression patterns obtained on the discovery series were consistently reproduced (data not shown), and the same selection criteria applied to MCP validation series identified significantly overlapping TM sets (data not shown). MCP-counter scores, exhibit a clear separation of the cell types on the discovery and two validation series (data not shown), with an AUC above 0.994 for each signature on the 4804 validation samples (data not shown).

Although their identification is data-driven, and not knowledge-driven, the selected TM largely overlap with known markers of the corresponding cell populations. They include for instance probesets mapping to CD3D and CD5 for T cells, CD8B for CD8+ T cells, EOMES and GNLY for cytotoxic lymphocytes, NCR1 (NKp46) and KIR genes for NK cells, CD 19, CD79A and CD79B for B cells, CSF1R for monocytic cells, CD1 molecules for myeloid dendritic cells, FCGR3B and CEACAM3 (CD66b) for neutrophils, VWF (von Willebrand Factor) and CDH5 (VE-cadherin) for endothelial cells, and DCN and TAGLN for fibroblasts (data not shown). In contrast, the screening process excluded from TM some genes usually considered as specific for a given cell population, such as BLK that we found overexpressed not only in B cells but also at a lower level in plasmacytoid dendritic cells, a result which supports the relevance of a data-driven approach (data not shown).

Since for a given cell population, the TM are expected to be coordinately expressed, we examined the correlation matrices of the TM on the three MCP datasets. We observed highly positive correlation matrices for all populations in the MCP datasets (data not shown). Having assessed the reproducibility of this approach, we reduced the number of markers for four populations (Neutrophils, Fibroblasts, Endothelial cells, B lineage) which had large (>90 markers) TM sets using information from the MCP validation series (Supplementary methods). We examined the correlation patterns of these final TM sets in 9408, 3548 and 6451 tumor transcriptomic samples (data not shown) obtained respectively using 'Affymetrix_HGU_133_Plus_2.0', 'Affymetrix_133A' and Illumina HiSeq transcriptomic platforms (Supplementary Tables S7-S9). We observed largely positive-valued correlation matrices for all MCP in the three tumor datasets, both in pan-cancer (data not shown) and single-cancer (data not shown) datasets.

Quantitative validation of MCP-counter abundance estimates We quantitatively validated the MCP-counter method. For this purpose, we designed an in- vitro RNA mixture experiment (data not shown). Immune populations were purified from healthy donors' peripheral blood; their RNAs were extracted and mixed in highly variable concentrations (from 0.7 to 46% of the sample's RNA). The RNA proportions of the populations were arranged in two transposed latin squares to avoid collinearity and thus ensure specificity (data not shown). The mixtures were further diluted in a fixed amount of a solution containing mRNA extracted from HCT-116, a colorectal cancer cell line. Transcriptome analyses revealed that MCP-counter scores were highly correlated with the cells' proportions in the mixtures (data not shown), with Pearson's correlation coefficients ranging from 0.94 to 0.99. In addition, immunohistochemical (IHC) digital quantifications of CD3+, CD8a+ and CD68+ cell densities were performed on tissue sections from 38 colorectal-cancer tumors. The IHC-measured densities of each cell population was found to correlate with the corresponding MCP-counter score (data not shown).

Finally, we assessed the limit of detection of the technique for each cell population using non-hematopoietic control samples. For each assayed population, we observed a limit of detection below 2% (depending on the population, from 1/950 to 1/50 of the sample's total RNA) (data not shown). Altogether, these results validate the use of the MCP-counter method to directly compare the abundance of the corresponding cell population across transcriptomic samples.

Comparison of MCP-counter with previously-published methods

MCP-counter differs from methods such as CIBERSORT, which aims to measure intra- sample, within leukocytes, proportions of immune cell populations, while MCP-counter outputs an abundance estimate per cell population that enables an inter-sample comparison, at the cost of being expressed in arbitrary units. To illustrate these differences, we simulated mRNA mixtures where the within-leukocytes proportion of five immune cell populations was kept constant and equal, while the proportions of tumor cells varied (Figure 4a). In this setting, only MCP-counter was able to accurately reflect the difference in immune cells' abundances across simulated mixtures, while CIBERSORT (accurately) estimated stable proportions of each immune cell populations within the leukocytic fraction of the simulated mixtures.

To compare the robustness of TM sets used in MCP-counter and those identified in previously-published methods, we computed metagene scores on the three MCP series with TM sets reported by Bindea et al. or by Yoshihara et al. We show that TM sets used in MCP- counter are better at discriminating between positive and negative MCP samples (Figure 4b). Notably, MCP-counter scores achieved high specificity and sentivity for each of the corresponding cell populations, while some TM sets from other methods were sometimes highly expressed in negative samples (for instance, the 'T cells' TM set from Bindea et al. was highly expressed in NK cells) (data not shown).

Analysis of the microenvironment of normal and cancer tissues

We applied MCP-counter to a first dataset of 505 samples spanning 47 non-pathological anatomical locations[14]. Lymphoid organs (Spleen, lymph nodes, tonsils, bone marrow) were, as expected, found to harbor a high number of immune cells, while the thymus featured the highest MCP-counter score for CD3+ T cells (data not shown). On the other hand, known "immune sanctuaries" such as testes were correctly found to feature little abundance of immune cells.

Tumor immunology is one of the natural applications of MCP-counter. We estimated the abundance of immune and non-immune cell populations in 19,407 samples spanning 32 non-hematopoietic human tumors, thus proposing a global analysis of non-malignant cell populations' abundances across human cancers (data not shown). The MCP-scores obtained from the three underlying transcriptome platforms ('Affymetrix_HGU_133_Plus_2.0', 'Affymetrix_133A' and Illumina HiSeq) yielded reproducible patterns across cancer types (data not shown) and were thus averaged to produce a synthetic view (data not shown). We observed that kidney clear-cell carcinoma had the highest abundance of endothelial cells of all cancers, while uveal melanomas, which occur in the eye, an immune sanctuary, are poorly infiltrated by immune cells. Colorectal cancer samples were average in terms of immune cells abundance. Gliomas and glioblastomas appeared poorly-infiltrated by T cells. The often viral- induced cervical squamous carcinoma is highly infiltrated by cytotoxic T and NK cells, but poorly by cells of monocytic origin.

Prognostic value associated with MCP-counter estimates

The three tumor series included respectively 2631, 1615 and 6047 Overall- Survival (OS)-annotated samples. We additionally curated 1591 tumor transcriptomes with OS annotations obtained using other transcriptomic platforms (data not shown). By performing a meta-analysis of univariate Cox models adjusted on each independent study, we assessed the correlation between the abundance of each microenvironment cell population, as estimated by MCP-scores, and OS within cancer types (data not shown). Although this univariate analysis was not adjusted for variables potentially influencing OS, such as tumor stage or treatments received, it nonetheless appeared consistent with published literature, notably revealing an overall favorable prognosis associated with infiltration by T cells, except in kidney clear-cell carcinoma as previously reported and in low grade glioma. Fibroblasts were mostly associated with poor outcome.

To assess whether MCP-counter was relevant to identify tumor subgroups based on their relative infiltration by multiple cell populations, we attempted to reproduce previously-reported prognostic classifications. In lung non-small cell adenocarcinoma, it was recently reported that infiltration by B or T cells independently predict favorable prognosis. In colorectal cancer, extensive literature exists about the protective role of a high infiltration by T cells, while fibroblasts were reported to be associated with poor outcome. In breast cancer, a stratification relying on cytotoxic T cells (associated with favorable outcome) and macrophages (poor outcome) was proposed. Using MCP-counter, we were able to reproduce these clinically- relevant patterns (data not shown). Discussion

Tissue-infiltrating immune and non-immune stromal cells contribute to the measured signal in gene expression experiments. Retrieving this information can yield estimates of the abundance of tissue -infiltrating cells, illustrated herein in cancer samples. To harness this information, we developed the Microenvironment Cell Population (MCP)-counter method, implemented in an easy-to-use R package.

It produces a score for each of 10 distinct MCP. We validated that these scores are accurate abundance estimates in three different settings: a) transcriptomic profiles of 4804 validation MCP samples, in which MCP-counter score separated 'positive' and 'negative' samples (relative to each of the 10 cell populations) with high specificity and sensitivity, b) in an in-vitro RNA mixture setting, where we showed that MCP-counter scores corresponding to the cell populations from which RNA were extracted highly correlated (Pearson's correlation coefficients ranging from 0.94 to 0.99) with the RNA fraction of the corresponding cell population in the mixture, and c) in an ex-vivo setting where we showed that MCP-counter estimates correlated with IHC measurements of the corresponding cells' densities. Using the in-vitro setting, we showed that MCP-counter' s lower limit of detection for a population was below 2% of the sample's total RNA proportion when using 'Affymetrix_HGU_133_Plus_2.0' microarrays. This limit of detection might be lowered by using more sensitive gene expression techniques, such as rt-qPCR, Nanostring, or RNA-sequencing assays. Other techniques to quantitatively characterize the cellular composition of a heterogeneous tissue notably include flow cytometry and enzymatic IHC. MCP-counter estimates are conceptually close to IHC-estimated cell densities (number of cells per surface unit on a tissue section), as the produced estimates can be used to compare the abundance of the corresponding cell populations across samples. However, unlike IHC, MCP-counter enables the simultaneous quantification of 10 cell populations with a single gene-expression experiment, while IHC quantifications are usually limited to a couple of markers. The information of the cells' spatial localization, which is available in IHC experiments, is however lost when using transcriptomic technologies.

MCP-counter is more sensitive and specific in the interpretation of its scores than other previously-published TM-based methods, through a rigorous, unbiased and conservative approach to define the TM sets on which it is based (data not shown). These methods were also limited to only two populations, or were not quantitatively validated. It conceptually differs from flow cytometry (FC) experiments or FC-inspired computational methods such as CIBERSORT, which aim at describing the relative proportions of various cell populations within a single sample (data not shown). In contrast, MCP-counter is specifically designed to compare the absolute abundance of a given cell population across multiple samples.

MCP-counter scores linearly correlate with the corresponding cell population's abundances across samples, but are expressed in arbitrary units. These arbitrary units are dependent on the gene expression platform used to produce the data and one can only compare samples produced with the same gene expression platforms. Nonetheless, we showed that the relative cellular abundance across three large tumor datasets, totaling more than 19,000 tumors, and obtained with three different gene expression platform, are largely consistent (data not shown), legitimating the use of MCP-counter to assess which samples are most or least infiltrated by each characterized cell population.

We illustrated the use of MCP-counter on non-diseased human tissues where we observed abundance estimates consistent with known immunological status of the samples. We applied MCP-counter to describe the average MCP cellular abundances in 32 non- hematopoietic human malignancies. This analysis confirmed the very high vascularization of clear-cell renal-cell carcinoma, and showed that cervical squamous cell carcinoma tumors, which are often virally-induced, are highly infiltrated by T lymphocytes, and notably cytotoxic T cells, but only moderately by other immune subsets.

MCP-counter is most relevant to stratify a cohort of similar samples based on the composition of their immune and stromal microenvironments, or to follow the composition of the microenvironment over time. The use of MCP-counter confirmed that significant univariate association between OS and tumor infiltration by cytotoxic lymphocytes were mostly positive. In contrast, significant associations between prognosis and extensive abundance of nonimmune stromal cell populations, and notably fibroblasts, are shown mostly negative using MCP-counter. These observations, largely consistent with published literature, validate the use of MCP-counter to assess the prognostic value of MCP in other cohorts of patients.

MCP-counter complements IHC approaches in that it enables the analysis of 10 cell populations using a single gene expression experiment. We notably illustrated its use to separately classify lung adenocarcinoma, colorectal, and breast tumors into microenvironment- defined subgroups. In this setting, we were able to confirm the prognostic impact of three previously-published microenvironment-based tumor classifications. These results suggest that MCP-counter may enable the identification of new multi-markers microenvironmental stratifications.

MCP-counter relies on TM which have been identified in a dataset containing GEP of cancer cell lines from 21 different anatomic locations among its negative controls, ensuring applicability in a wide range of samples. This large diversity of control samples may however discard TM which would be relevant in a specific setting: for instance, the screening procedure discarded NCAM 1 (CD56), a widely-used marker of NK cells, as it is also expressed by nervous malignant cells, and is thus unsuitable to quantify NK cells in brain samples. The general framework that we developed herein could thus be tailored to identify additional TM for investigation in a more restricted set of organs.

MCP-counter can be incorporated in clinical routine to characterize immune infiltration in samples where IHC-based quantifications are impossible, such as for fine-needle aspiration biopsies. In this setting, samples are typically collected one at a time. To complement the current multi-sample use of MCP-counter, designed for exploratory analyses, one could notably settle on a desired gene expression platform and use a set of calibrating samples. For instance, in- vitro RNA mixtures described herein could help mapping MCP-counter abundance scores to non-arbitrary units, such as the percentage of the corresponding cells within a sample.

To our knowledge, MCP-counter is the first validated computational method that enables a robust quantification of the abundance of multiple immune and non-immune stromal populations in the transcriptome of cellularly-heterogeneous tissues such as normal or malignant tissues. It might be relevant in a clinical setting, as immune biomarkers can help predict patient's prognosis or response to therapies, most notably to immunotherapies. Its retrospective and prospective application to study inflammatory profiles through transcriptomics should help unraveling the role of immune and stromal populations in cancers and other diseases, and help decipher the interplay between these populations.

Table 1: Gene signatures for quantifying the population of neutrophils and others cells in a tissue sample.

Complete gene signatures were obtained based on the methodology described in EXAMPLE. In this example, it is shown that the complet signatures are able to predict corresponding cell types' proportions in a heterogeneous tissue.

Let S be a signature, composed of n probesets ;</<«.

9697 tumor transcriptomes from multiple cancer types were obtained from public repositories. Expression values for each probesets wer mean-centered across samples (row centering). The expression values from probesets within S were then averaged to obtain a single representativ value for each sample : meani<i<n(f).

We then computed, for each combination fiub of length from 1 and up to 10 probesets of S, the average expression mean(fsub) for eac sample.

We then correlated mean(fsub) to meani<i<n(f).

When available, we correlated the true-proportions of mRNA from the corresponding cell type in the in-vitro RNA-mixture validatio model described in EXAMPLE to mean(fsub).

Combinations were ranked according to their ability to correlate with in-vitro RNA proportions, if available or with their ability to correlat to the summarized expression of the complete set of marker.

Table 1: combination of genes

Combination of genes for identification of B cells

Figure imgf000049_0001

3 MS4A1 CR2 BANK1 NA NA NA NA NA NA NA 0,93563326 0,9962679

4 MS4A1 CR2 BANK1 PAX5 NA NA NA NA NA NA 0,93326143 0,9953429

4 MS4A1 CD19 CR2 BANK1 NA NA NA NA NA NA 0,9550717 0,995320

2 MS4A1 BANK1 NA NA NA NA NA NA NA NA 0,92281625 0,9953078

4 MS4A1 CR2 FCRL2 BANK1 NA NA NA NA NA NA 0,94797522 0,9948192

3 C 2 BANK1 PAX5 NA NA NA NA NA NA NA 0,87288207 0,9940614

5 MS4A1 CD19 CR2 BANK1 PAX5 NA NA NA NA NA 0,95131115 0,9939774

2 CR2 BANK1 NA NA NA NA NA NA NA NA 0,86624957 0,9938889

1 BANK1 NA NA NA NA NA NA NA NA NA 0,7391599 0,9938451

4 MS4A1 CR2 BANK1 CD22 NA NA NA NA NA NA 0,94452501 0,9936387

5 MS4A1 CR2 BANK1 PAX5 CD22 NA NA NA NA NA 0,94359934 0,9933714

1 MS4A1 NA NA NA NA NA NA NA NA NA 0,91226624 0,9933352

3 CR2 FCRL2 BANK1 NA NA NA NA NA NA NA 0,89896886 0,9933113

3 MS4A1 CD19 BANK1 NA NA NA NA NA NA NA 0,95471648 0,9932270

5 MS4A1 CR2 FCRL2 BANK1 PAX5 NA NA NA NA NA 0,94578471 0,9931014

5 MS4A1 CD19 CR2 FCRL2 BANK1 NA NA NA NA NA 0,9603499 0,9930526

3 MS4A1 BANK1 PAX5 NA NA NA NA NA NA NA 0,91796041 0,9928050

3 CD19 CR2 BANK1 NA NA NA NA NA NA NA 0,91829543 0,992496

3 MS4A1 CR2 PAX5 NA NA NA NA NA NA NA 0,9062648 0,9924944

3 MS4A1 CR2 FCRL2 NA NA NA NA NA NA NA 0,93733292 0,9923608

5 MS4A1 CD19 CR2 BANK1 CD22 NA NA NA NA NA 0,95894958 0,9923403

5 MS4A1 CR2 FCRL2 BANK1 CD22 NA NA NA NA NA 0,95488479 0,9922451

4 CR2 BANK1 PAX5 CD22 NA NA NA NA NA NA 0,89269044 0,992233

3 CR2 BANK1 CD22 NA NA NA NA NA NA NA 0,88419484 0,9920541

6 MS4A1 CD19 CR2 BANK1 PAX5 CD22 NA NA NA NA 0,9571508 0,9920075

3 MS4A1 FCRL2 BANK1 NA NA NA NA NA NA NA 0,94298914 0,9918348

4 CD19 CR2 BANK1 PAX5 NA NA NA NA NA NA 0,9149227 0,9918306

6 MS4A1 CD19 CR2 FCRL2 BANK1 PAX5 NA NA NA NA 0,95795815 0,9916885

6 MS4A1 CR2 FCRL2 BANK1 PAX5 CD22 NA NA NA NA 0,95399996 0,9915414

4 MS4A1 CR2 PAX5 CD22 NA NA NA NA NA NA 0,91790571 0,9914221

4 C 2 FCRL2 BANK1 PAX5 NA NA NA NA NA NA 0,90135266 0,9913197

4 MS4A1 CD19 BANK1 PAX5 NA NA NA NA NA NA 0,94661979 0,9911385

3 MS4A1 CR2 CD22 NA NA NA NA NA NA NA 0,92594051 0,9908419

6 MS4A1 CD19 CR2 FCRL2 BANK1 CD22 NA NA NA NA 0,96384824 0,9907830

5 MS4A1 CR2 BANK1 IGKC PAX5 NA NA NA NA NA 0,96798904 0,9907495

3 MS4A1 BANK1 CD22 NA NA NA NA NA NA NA 0,93586662 0,9905730

4 CR2 FCRL2 BANK1 CD22 NA NA NA NA NA NA 0,91059616 0,990567

4 MS4A1 CR2 FCRL2 PAX5 NA NA NA NA NA NA 0,92532405 0,9904810

4 CD19 CR2 FCRL2 BANK1 NA NA NA NA NA NA 0,92952112 0,99043

2 MS4A1 CR2 NA NA NA NA NA NA NA NA 0,92135589 0,9904117

4 MS4A1 BANK1 PAX5 CD22 NA NA NA NA NA NA 0,93365311 0,9903956

6 MS4A1 CD19 CR2 BANK1 IGKC PAX5 NA NA NA NA 0,97614328 0,9903863

4 MS4A1 CD19 CR2 PAX5 NA NA NA NA NA NA 0,93265131 0,9903197

7 MS4A1 CD19 CR2 FCRL2 BANK1 PAX5 CD22 NA NA NA 0,96293755 0,9902765

5 MS4A1 CD19 CR2 BANK1 IGKC NA NA NA NA NA 0,96930951 0,9902720

5 CD19 CR2 BANK1 PAX5 CD22 NA NA NA NA NA 0,92394658 0,9901592

5 CR2 FCRL2 BANK1 PAX5 CD22 NA NA NA NA NA 0,91540357 0,9899820

4 MS4A1 CR2 FCRL2 CD22 NA NA NA NA NA NA 0,94066403 0,9899589

3 MS4A1 CD19 CR2 NA NA NA NA NA NA NA 0,94532322 0,9899246

2 BANK1 PAX5 NA NA NA NA NA NA NA NA 0,79184882 0,9899236

4 CD19 CR2 BANK1 CD22 NA NA NA NA NA NA 0,92261967 0,9898929

4 MS4A1 CR2 BANK1 IGKC NA NA NA NA NA NA 0,95836094 0,9898736

4 MS4A1 FCRL2 BANK1 PAX5 NA NA NA NA NA NA 0,93789227 0,9898065

4 MS4A1 CD19 FCRL2 BANK1 NA NA NA NA NA NA 0,96095618 0,9897501

5 MS4A1 CR2 FCRL2 PAX5 CD22 NA NA NA NA NA 0,93390717 0,9894286

5 CD19 CR2 FCRL2 BANK1 PAX5 NA NA NA NA NA 0,92828861 0,9893098

4 MS4A1 CD19 CR2 FCRL2 NA NA NA NA NA NA 0,9511751 0,9892464

5 MS4A1 CD19 CR2 PAX5 CD22 NA NA NA NA NA 0,93816482 0,9892407

Figure imgf000052_0001

6 MS4A1 CD19 CR2 FCRL2 PAX5 CD22 NA NA NA NA 0,94689658 0,9875988

5 MS4A1 CD19 FCRL2 BANK1 CD22 NA NA NA NA NA 0,96425538 0,9873529

8 MS4A1 CD19 CR2 FCRL2 BANK1 IGKC PAX5 CD22 NA NA 0,98727506 0,9872009

5 MS4A1 CD19 CR2 IGKC PAX5 NA NA NA NA NA 0,96077108 0,9871884

6 MS4A1 CD19 FCRL2 BANK1 PAX5 CD22 NA NA NA NA 0,96184143 0,987146

6 MS4A1 CR2 FCRL2 BANK1 IGKC CD22 NA NA NA NA 0,97760869 0,9871200

3 MS4A1 PAX5 CD22 NA NA NA NA NA NA NA 0,89237448 0,9871184

3 C 2 BANK1 IGKC NA NA NA NA NA NA NA 0,91707241 0,9870749

3 CD19 BANK1 PAX5 NA NA NA NA NA NA NA 0,8845682 0,987074

2 BANK1 CD22 NA NA NA NA NA NA NA NA 0,79792646 0,9870430

5 CR2 FCRL2 BANK1 IGKC PAX5 NA NA NA NA NA 0,94944549 0,9870294

5 CR2 BANK1 IGKC PAX5 CD22 NA NA NA NA NA 0,9575633 0,9870046

7 MS4A1 CD19 CR2 FCRL2 BANK1 IGKC CD22 NA NA NA 0,98195468 0,9867820

6 CD19 CR2 BANK1 IGKC PAX5 CD22 NA NA NA NA 0,96793387 0,9864087

4 CR2 FCRL2 BANK1 IGKC NA NA NA NA NA NA 0,93202706 0,9863949

4 CR2 FCRL2 PAX5 CD22 NA NA NA NA NA NA 0,86704657 0,9863909

6 CD19 CR2 FCRL2 BANK1 IGKC PAX5 NA NA NA NA 0,96090204 0,9863177

2 MS4A1 CD22 NA NA NA NA NA NA NA NA 0,90971678 0,9862061

3 FCRL2 BANK1 PAX5 NA NA NA NA NA NA NA 0,85624311 0,9861599

5 MS4A1 CR2 FCRL2 IGKC PAX5 NA NA NA NA NA 0,95734596 0,986099

3 CR2 FCRL2 CD22 NA NA NA NA NA NA NA 0,8655927 0,9860682

5 MS4A1 CR2 IGKC PAX5 CD22 NA NA NA NA NA 0,96336206 0,9860425

2 CR2 FCRL2 NA NA NA NA NA NA NA NA 0,86214574 0,9859517

5 CD19 CR2 FCRL2 BANK1 IGKC NA NA NA NA NA 0,94868775 0,9859247

2 MS4A1 CD19 NA NA NA NA NA NA NA NA 0,94960466 0,985866

5 MS4A1 CD19 BANK1 IGKC PAX5 NA NA NA NA NA 0,96647529 0,9858459

3 CR2 FCRL2 PAX5 NA NA NA NA NA NA NA 0,84809113 0,9857680

4 MS4A1 CD19 CR2 IGKC NA NA NA NA NA NA 0,95301933 0,9857365

6 CR2 FCRL2 BANK1 IGKC PAX5 CD22 NA NA NA NA 0,96525917 0,985732

4 CD19 BANK1 PAX5 CD22 NA NA NA NA NA NA 0,90007337 0,9856880

2 C 2 PAX5 NA NA NA NA NA NA NA NA 0,79277849 0,9856636

4 MS4A1 BANK1 IGKC PAX5 NA NA NA NA NA NA 0,95246454 0,9855682

4 FCRL2 BANK1 PAX5 CD22 NA NA NA NA NA NA 0,88304022 0,9854784

6 MS4A1 CD19 CR2 IGKC PAX5 CD22 NA NA NA NA 0,9711505 0,9854732

3 MS4A1 CD19 PAX5 NA NA NA NA NA NA NA 0,92005584 0,9854594

6 MS4A1 CD19 CR2 FCRL2 IGKC PAX5 NA NA NA NA 0,96581706 0,9853980

3 MS4A1 FCRL2 PAX5 NA NA NA NA NA NA NA 0,90706276 0,9853446

3 FCRL2 BANK1 CD22 NA NA NA NA NA NA NA 0,86683129 0,9853412

4 MS4A1 CR2 FCRL2 IGKC NA NA NA NA NA NA 0,94766315 0,9851330

7 CD19 CR2 FCRL2 BANK1 IGKC PAX5 CD22 NA NA NA 0,97208761 0,9851010

4 CD19 CR2 PAX5 CD22 NA NA NA NA NA NA 0,88159827 0,9850547

6 MS4A1 CR2 FCRL2 IGKC PAX5 CD22 NA NA NA NA 0,96982432 0,985030

4 MS4A1 FCRL2 PAX5 CD22 NA NA NA NA NA NA 0,92003739 0,9849199

5 CD19 CR2 BANK1 IGKC CD22 NA NA NA NA NA 0,95665677 0,9848567

2 CR2 CD22 NA NA NA NA NA NA NA NA 0,81306738 0,9848464

3 MS4A1 FCRL2 CD22 NA NA NA NA NA NA NA 0,93482697 0,9848316

3 CD19 FCRL2 BANK1 NA NA NA NA NA NA NA 0,91084648 0,9847682

5 MS4A1 CD19 CR2 FCRL2 IGKC NA NA NA NA NA 0,95881036 0,9847274

4 CR2 BANK1 IGKC CD22 NA NA NA NA NA NA 0,94127473 0,98472

4 MS4A1 CD19 PAX5 CD22 NA NA NA NA NA NA 0,92731117 0,98470

4 MS4A1 CD19 BANK1 IGKC NA NA NA NA NA NA 0,95419459 0,9846222

3 MS4A1 CR2 IGKC NA NA NA NA NA NA NA 0,93693495 0,9846105

5 CR2 FCRL2 BANK1 IGKC CD22 NA NA NA NA NA 0,95164541 0,9845666

3 CD19 BANK1 CD22 NA NA NA NA NA NA NA 0,89473925 0,9845259

7 MS4A1 CD19 CR2 FCRL2 IGKC PAX5 CD22 NA NA NA 0,97487891 0,984386

5 MS4A1 FCRL2 BANK1 IGKC PAX5 NA NA NA NA NA 0,96206758 0,9843705

6 MS4A1 CD19 BANK1 IGKC PAX5 CD22 NA NA NA NA 0,97888851 0,9843269

6 MS4A1 CD19 FCRL2 BANK1 IGKC PAX5 NA NA NA NA 0,97178589 0,9843002

5 MS4A1 BANK1 IGKC PAX5 CD22 NA NA NA NA NA 0,97023122 0,9842940

4 CD19 FCRL2 BANK1 PAX5 NA NA NA NA NA NA 0,90897621 0,9842579

6 CD19 CR2 FCRL2 BANK1 IGKC CD22 NA NA NA NA 0,96196929 0,9841569

5 CD19 FCRL2 BANK1 PAX5 CD22 NA NA NA NA NA 0,91998267 0,9838895

5 CD19 CR2 FCRL2 PAX5 CD22 NA NA NA NA NA 0,90222881 0,9838480

3 C 2 IGKC PAX5 NA NA NA NA NA NA NA 0,89931683 0,9836816

5 MS4A1 CR2 FCRL2 IGKC CD22 NA NA NA NA NA 0,96229407 0,9836570

6 MS4A1 FCRL2 BANK1 IGKC PAX5 CD22 NA NA NA NA 0,97698788 0,9835705

5 MS4A1 CD19 FCRL2 BANK1 IGKC NA NA NA NA NA 0,96107127 0,9835634

5 MS4A1 CD19 CR2 IGKC CD22 NA NA NA NA NA 0,96486755 0,9835466

3 MS4A1 CD19 FCRL2 NA NA NA NA NA NA NA 0,95369624 0,9835415

7 MS4A1 CD19 FCRL2 BANK1 IGKC PAX5 CD22 NA NA NA 0,98253411 0,9834013

4 CD19 FCRL2 BANK1 CD22 NA NA NA NA NA NA 0,91535662 0,9832675

4 MS4A1 CR2 IGKC CD22 NA NA NA NA NA NA 0,9545773 0,9832629

6 MS4A1 CD19 CR2 FCRL2 IGKC CD22 NA NA NA NA 0,96903096 0,9832563

4 MS4A1 CD19 FCRL2 PAX5 NA NA NA NA NA NA 0,93485975 0,9832030

5 MS4A1 CD19 FCRL2 PAX5 CD22 NA NA NA NA NA 0,94034571 0,9831607

3 MS4A1 CD19 CD22 NA NA NA NA NA NA NA 0,94172605 0,9831580

4 MS4A1 FCRL2 BANK1 IGKC NA NA NA NA NA NA 0,94694587 0,9831463

3 CD19 CR2 PAX5 NA NA NA NA NA NA NA 0,87072221 0,9829025

3 MS4A1 BANK1 IGKC NA NA NA NA NA NA NA 0,93391049 0,9828665

4 CD19 CR2 FCRL2 PAX5 NA NA NA NA NA NA 0,89439966 0,9828612

4 CD19 CR2 IGKC PAX5 NA NA NA NA NA NA 0,92664517 0,9828200

6 MS4A1 CD19 CD79A CR2 BANK1 PAX5 NA NA NA NA 0,96695517 0,9827556

5 MS4A1 CD19 BANK1 IGKC CD22 NA NA NA NA NA 0,96908174 0,982598

4 CR2 IGKC PAX5 CD22 NA NA NA NA NA NA 0,92481613 0,9825254

4 CD19 CR2 FCRL2 CD22 NA NA NA NA NA NA 0,90360172 0,9825207

4 MS4A1 CD19 FCRL2 CD22 NA NA NA NA NA NA 0,94990986 0,982408

6 MS4A1 CD19 FCRL2 BANK1 IGKC CD22 NA NA NA NA 0,973755 0,9822757

5 MS4A1 FCRL2 BANK1 IGKC CD22 NA NA NA NA NA 0,96524212 0,9820955

4 C 2 FCRL2 IGKC PAX5 NA NA NA NA NA NA 0,91809393 0,9820611

7 MS4A1 CD19 CD79A CR2 BANK1 PAX5 CD22 NA NA NA 0,97169449 0,9820593

5 CD19 CR2 IGKC PAX5 CD22 NA NA NA NA NA 0,94311014 0,9817492

7 MS4A1 CD19 CD79A CR2 FCRL2 BANK1 PAX5 NA NA NA 0,96974089 0,9817236

4 MS4A1 BANK1 IGKC CD22 NA NA NA NA NA NA 0,95620009 0,9817133

5 CR2 FCRL2 IGKC PAX5 CD22 NA NA NA NA NA 0,93852849 0,9816993

4 CD19 BANK1 IGKC PAX5 NA NA NA NA NA NA 0,92981205 0,9816616

8 MS4A1 CD19 CD79A CR2 FCRL2 BANK1 PAX5 CD22 NA NA 0,9740553 0,9813965

5 MS4A1 CD79A CR2 BANK1 PAX5 NA NA NA NA NA 0,95915221 0,9813648

6 MS4A1 CD79A CR2 BANK1 PAX5 CD22 NA NA NA NA 0,966518 0,9812887

3 CD19 CR2 CD22 NA NA NA NA NA NA NA 0,88473797 0,9812691

5 CD19 CR2 FCRL2 IGKC PAX5 NA NA NA NA NA 0,93701638 0,9812132

5 MS4A1 CD19 CD79A CR2 BANK1 NA NA NA NA NA 0,96903417 0,9811185

3 CD19 CR2 FCRL2 NA NA NA NA NA NA NA 0,90631527 0,9810422

3 BANK1 IGKC PAX5 NA NA NA NA NA NA NA 0,89725776 0,9809896

7 MS4A1 CD79A CR2 FCRL2 BANK1 PAX5 CD22 NA NA NA 0,97100663 0,9809751

6 MS4A1 CD79A CR2 FCRL2 BANK1 PAX5 NA NA NA NA 0,96467057 0,9809512

6 CD19 CR2 FCRL2 IGKC PAX5 CD22 NA NA NA NA 0,95080332 0,9809280

5 CD19 BANK1 IGKC PAX5 CD22 NA NA NA NA NA 0,95004811 0,9806873

2 PAX5 CD22 NA NA NA NA NA NA NA NA 0,66715922 0,9806601

6 MS4A1 CD19 CD79A CR2 FCRL2 BANK1 NA NA NA NA 0,97045527 0,9805900

4 BANK1 IGKC PAX5 CD22 NA NA NA NA NA NA 0,92887121 0,9804843

5 CD19 FCRL2 BANK1 IGKC PAX5 NA NA NA NA NA 0,9413525 0,9803194

6 MS4A1 CD19 CD79A CR2 BANK1 CD22 NA NA NA NA 0,97262371 0,9802649

4 FCRL2 BANK1 IGKC PAX5 NA NA NA NA NA NA 0,91896451 0,9801774

7 MS4A1 CD19 CD79A CR2 FCRL2 BANK1 CD22 NA NA NA 0,97395376 0,9801186

5 FCRL2 BANK1 IGKC PAX5 CD22 NA NA NA NA NA 0,94407234 0,9801137

6 CD19 FCRL2 BANK1 IGKC PAX5 CD22 NA NA NA NA 0,95811598 0,9800358

4 MS4A1 CD19 IGKC PAX5 NA NA NA NA NA NA 0,94318027 0,9800357

5 MS4A1 CD19 IGKC PAX5 CD22 NA NA NA NA NA 0,95854665 0,9795456

4 MS4A1 IGKC PAX5 CD22 NA NA NA NA NA NA 0,94380945 0,9792785

5 MS4A1 FCRL2 IGKC PAX5 CD22 NA NA NA NA NA 0,95531605 0,9792565

6 MS4A1 CD79A CR2 FCRL2 BANK1 CD22 NA NA NA NA 0,97160337 0,9792131

5 MS4A1 CD19 FCRL2 IGKC PAX5 NA NA NA NA NA 0,95205318 0,9791820

6 MS4A1 CD19 FCRL2 IGKC PAX5 CD22 NA NA NA NA 0,96502514 0,9791809

3 MS4A1 IGKC PAX5 NA NA NA NA NA NA NA 0,92070233 0,9791302

3 FC L2 PAX5 CD22 NA NA NA NA NA NA NA 0,78166002 0,9790561

5 MS4A1 CD79A CR2 FCRL2 BANK1 NA NA NA NA NA 0,9660653 0,9790560

4 MS4A1 FCRL2 IGKC PAX5 NA NA NA NA NA NA 0,93653115 0,9789914

3 CR2 FCRL2 IGKC NA NA NA NA NA NA NA 0,89343488 0,9789492

4 CR2 FCRL2 IGKC CD22 NA NA NA NA NA NA 0,91971045 0,9788071

4 CD19 CR2 FCRL2 IGKC NA NA NA NA NA NA 0,92092762 0,9787741

5 MS4A1 CD79A CR2 BANK1 CD22 NA NA NA NA NA 0,9681436 0,9785441

5 CD19 CR2 FCRL2 IGKC CD22 NA NA NA NA NA 0,93764622 0,9784964

6 CD19 CD79A CR2 BANK1 PAX5 CD22 NA NA NA NA 0,95127079 0,9782826

5 CD19 CD79A CR2 BANK1 PAX5 NA NA NA NA NA 0,94504848 0,9781818

4 CD19 FCRL2 BANK1 IGKC NA NA NA NA NA NA 0,91795311 0,9781553

3 CD19 BANK1 IGKC NA NA NA NA NA NA NA 0,90100089 0,9780445

4 MS4A1 CD79A CR2 BANK1 NA NA NA NA NA NA 0,96186986 0,9780332

7 CD19 CD79A CR2 FCRL2 BANK1 PAX5 CD22 NA NA NA 0,95566884 0,9779430

3 CD19 CR2 IGKC NA NA NA NA NA NA NA 0,90732523 0,9778284

5 CD19 FCRL2 BANK1 IGKC CD22 NA NA NA NA NA 0,93936416 0,9778013

9 MS4A1 CD19 CD79A CR2 FCRL2 BANK1 IGKC PAX5 CD22 NA 0,98671507 0,9777827

8 MS4A1 CD19 CD79A CR2 BANK1 IGKC PAX5 CD22 NA NA 0,98534791 0,9776745

8 MS4A1 CD19 CD79A CR2 FCRL2 BANK1 IGKC PAX5 NA NA 0,97940489 0,977629

7 MS4A1 CD19 CD79A CR2 BANK1 IGKC PAX5 NA NA NA 0,97726667 0,9775810

6 CD19 CD79A CR2 FCRL2 BANK1 PAX5 NA NA NA NA 0,95009381 0,9775495

4 CD19 CR2 IGKC CD22 NA NA NA NA NA NA 0,92778329 0,9775179

4 FC L2 BANK1 IGKC CD22 NA NA NA NA NA NA 0,91641146 0,9772445

6 CD79A CR2 FCRL2 BANK1 PAX5 CD22 NA NA NA NA 0,9485502 0,9772188

4 CD19 BANK1 IGKC CD22 NA NA NA NA NA NA 0,92759362 0,9771709

5 CD79A CR2 BANK1 PAX5 CD22 NA NA NA NA NA 0,93988497 0,9770151

3 FCRL2 BANK1 IGKC NA NA NA NA NA NA NA 0,88253236 0,9769807

6 MS4A1 CD19 CD79A CR2 PAX5 CD22 NA NA NA NA 0,95629669 0,9769698

3 CD19 PAX5 CD22 NA NA NA NA NA NA NA 0,8187019 0,9769512

7 MS4A1 CD19 CD79A CR2 FCRL2 PAX5 CD22 NA NA NA 0,96027221 0,9769456

4 CD19 FCRL2 PAX5 CD22 NA NA NA NA NA NA 0,86259045 0,9768725

8 MS4A1 CD79A CR2 FCRL2 BANK1 IGKC PAX5 CD22 NA NA 0,98507623 0,9767919

5 MS4A1 CD19 FCRL2 IGKC CD22 NA NA NA NA NA 0,95410459 0,976676

4 MS4A1 CD19 FCRL2 IGKC NA NA NA NA NA NA 0,93852251 0,9765830

3 CR2 IGKC CD22 NA NA NA NA NA NA NA 0,90084353 0,9765017

5 MS4A1 CD19 CD79A CR2 PAX5 NA NA NA NA NA 0,95172964 0,9762987

6 MS4A1 CD19 CD79A CR2 FCRL2 PAX5 NA NA NA NA 0,95612126 0,9762089

7 MS4A1 CD79A CR2 BANK1 IGKC PAX5 CD22 NA NA NA 0,98252299 0,9761904

5 CD79A CR2 FCRL2 BANK1 PAX5 NA NA NA NA NA 0,93946147 0,9761901

7 MS4A1 CD79A CR2 FCRL2 BANK1 IGKC PAX5 NA NA NA 0,97571901 0,9761829

2 FCRL2 CD22 NA NA NA NA NA NA NA NA 0,74212781 0,9761741

7 MS4A1 CD19 CD79A FCRL2 BANK1 PAX5 CD22 NA NA NA 0,97391176 0,9761511

6 MS4A1 CD79A CR2 FCRL2 PAX5 CD22 NA NA NA NA 0,95532684 0,9761342

4 MS4A1 FCRL2 IGKC CD22 NA NA NA NA NA NA 0,93988517 0,9760664

6 MS4A1 CD19 CD79A BANK1 PAX5 CD22 NA NA NA NA 0,97107887 0,9760244

4 CD79A CR2 BANK1 PAX5 NA NA NA NA NA NA 0,92872989 0,9757314

6 CD19 CD79A CR2 FCRL2 BANK1 CD22 NA NA NA NA 0,9536605 0,9756421

8 MS4A1 CD19 CD79A CR2 FCRL2 BANK1 IGKC CD22 NA NA 0,98068003 0,9756360

5 MS4A1 CD79A CR2 PAX5 CD22 NA NA NA NA NA 0,94817273 0,975511

4 MS4A1 CD19 IGKC CD22 NA NA NA NA NA NA 0,94586319 0,9754645

6 MS4A1 CD19 CD79A FCRL2 BANK1 PAX5 NA NA NA NA 0,96860583 0,97542

6 MS4A1 CD79A CR2 BANK1 IGKC PAX5 NA NA NA NA 0,97197232 0,9753422

5 MS4A1 CD19 CD79A BANK1 PAX5 NA NA NA NA NA 0,96512853 0,9753205

3 MS4A1 CD19 IGKC NA NA NA NA NA NA NA 0,92699652 0,9753200

3 BANK1 IGKC CD22 NA NA NA NA NA NA NA 0,89310271 0,9752863

7 MS4A1 CD19 CD79A CR2 FCRL2 BANK1 IGKC NA NA NA 0,97244881 0,9752382

3 MS4A1 FCRL2 IGKC NA NA NA NA NA NA NA 0,91615027 0,9752222

2 FC L2 PAX5 NA NA NA NA NA NA NA NA 0,72943062 0,9751113

6 MS4A1 CD79A FCRL2 BANK1 PAX5 CD22 NA NA NA NA 0,97007996 0,975028

5 CD19 CD79A CR2 FCRL2 BANK1 NA NA NA NA NA 0,94972197 0,9750235

5 CD19 CD79A CR2 BANK1 CD22 NA NA NA NA NA 0,95087491 0,9749479

7 MS4A1 CD19 CD79A CR2 BANK1 IGKC CD22 NA NA NA 0,9790282 0,974740

5 MS4A1 CD79A CR2 FCRL2 PAX5 NA NA NA NA NA 0,94882001 0,9746516

4 CD19 CD79A CR2 BANK1 NA NA NA NA NA NA 0,94728838 0,9743456

6 MS4A1 CD19 CD79A CR2 FCRL2 CD22 NA NA NA NA 0,96218803 0,9743405

5 MS4A1 CD79A BANK1 PAX5 CD22 NA NA NA NA NA 0,96399178 0,974221

6 MS4A1 CD19 CD79A CR2 BANK1 IGKC NA NA NA NA 0,96985889 0,9741534

8 CD19 CD79A CR2 FCRL2 BANK1 IGKC PAX5 CD22 NA NA 0,97288041 0,9741209

5 CD79A CR2 FCRL2 BANK1 CD22 NA NA NA NA NA 0,94710864 0,9740863

7 MS4A1 CD79A CR2 FCRL2 BANK1 IGKC CD22 NA NA NA 0,97793601 0,9739860

2 CR2 IGKC NA NA NA NA NA NA NA NA 0,86681086 0,9739464

2 BANK1 IGKC NA NA NA NA NA NA NA NA 0,84885578 0,973753

6 MS4A1 CD19 CD79A FCRL2 BANK1 CD22 NA NA NA NA 0,9739847 0,973644

5 MS4A1 CD79A FCRL2 BANK1 PAX5 NA NA NA NA NA 0,96167674 0,9735567

7 CD19 CD79A CR2 BANK1 IGKC PAX5 CD22 NA NA NA 0,97021925 0,9734944

5 CD19 FCRL2 IGKC PAX5 CD22 NA NA NA NA NA 0,92425149 0,9734351

4 MS4A1 CD79A CR2 PAX5 NA NA NA NA NA NA 0,94038371 0,973374

3 MS4A1 IGKC CD22 NA NA NA NA NA NA NA 0,92431357 0,9732671

7 CD19 CD79A CR2 FCRL2 BANK1 IGKC PAX5 NA NA NA 0,96292453 0,9732366

5 MS4A1 CD19 CD79A CR2 FCRL2 NA NA NA NA NA 0,96005737 0,9731736

3 CD19 FCRL2 PAX5 NA NA NA NA NA NA NA 0,84704201 0,9730949

4 FC L2 IGKC PAX5 CD22 NA NA NA NA NA NA 0,89755162 0,9730925

1 PAX5 NA NA NA NA NA NA NA NA NA 0,55670562 0,9730826

8 MS4A1 CD19 CD79A CR2 FCRL2 IGKC PAX5 CD22 NA NA 0,97429393 0,9730821

5 MS4A1 CD19 CD79A CR2 CD22 NA NA NA NA NA 0,96007687 0,9730702

3 CD19 FCRL2 CD22 NA NA NA NA NA NA NA 0,85860543 0,9730067

6 MS4A1 CD79A CR2 FCRL2 BANK1 IGKC NA NA NA NA 0,9671637 0,9727835

7 CD79A CR2 FCRL2 BANK1 IGKC PAX5 CD22 NA NA NA 0,96872754 0,9726806

5 MS4A1 CD79A CR2 FCRL2 CD22 NA NA NA NA NA 0,95931106 0,9726005

5 MS4A1 CD19 CD79A FCRL2 BANK1 NA NA NA NA NA 0,96992168 0,9725376

4 CD19 IGKC PAX5 CD22 NA NA NA NA NA NA 0,90854879 0,9725283

6 CD19 CD79A CR2 BANK1 IGKC PAX5 NA NA NA NA 0,95895989 0,9724599

5 MS4A1 CD19 CD79A BANK1 CD22 NA NA NA NA NA 0,97279629 0,9724325

8 MS4A1 CD19 CD79A FCRL2 BANK1 IGKC PAX5 CD22 NA NA 0,98136312 0,972315

1 CD22 NA NA NA NA NA NA NA NA NA 0,49124845 0,9722825

4 CD79A CR2 FCRL2 BANK1 NA NA NA NA NA NA 0,9398039 0,9721737

4 MS4A1 CD79A BANK1 PAX5 NA NA NA NA NA NA 0,95377549 0,9721568

7 MS4A1 CD19 CD79A CR2 IGKC PAX5 CD22 NA NA NA 0,97168222 0,9721490

6 MS4A1 CD79A CR2 BANK1 IGKC CD22 NA NA NA NA 0,97477367 0,972121

4 CD79A CR2 BANK1 CD22 NA NA NA NA NA NA 0,93992666 0,9719191

7 MS4A1 CD19 CD79A CR2 FCRL2 IGKC PAX5 NA NA NA 0,96594349 0,9718875

5 MS4A1 CD79A FCRL2 BANK1 CD22 NA NA NA NA NA 0,97131136 0,9716162

1 FCRL2 NA NA NA NA NA NA NA NA NA 0,74508284 0,9715809

7 MS4A1 CD79A CR2 FCRL2 IGKC PAX5 CD22 NA NA NA 0,97100347 0,9715203

3 IGKC PAX5 CD22 NA NA NA NA NA NA NA 0,86829048 0,9714197

4 MS4A1 CD19 CD79A CR2 NA NA NA NA NA NA 0,95842652 0,971371

4 CD19 FCRL2 IGKC PAX5 NA NA NA NA NA NA 0,90177063 0,9713416

6 CD19 CD79A CR2 FCRL2 PAX5 CD22 NA NA NA NA 0,93053719 0,9713027

7 MS4A1 CD19 CD79A BANK1 IGKC PAX5 CD22 NA NA NA 0,97890412 0,9713023

6 CD79A CR2 BANK1 IGKC PAX5 CD22 NA NA NA NA 0,96394968 0,9712926

7 MS4A1 CD19 CD79A FCRL2 BANK1 IGKC PAX5 NA NA NA 0,97170296 0,9710871

6 CD79A CR2 FCRL2 BANK1 IGKC PAX5 NA NA NA NA 0,95540805 0,9710388

4 MS4A1 CD19 CD79A BANK1 NA NA NA NA NA NA 0,96874678 0,9709188

6 CD19 CD79A FCRL2 BANK1 PAX5 CD22 NA NA NA NA 0,94720138 0,970839

7 CD19 CD79A CR2 FCRL2 BANK1 IGKC CD22 NA NA NA 0,96253043 0,9708321

6 MS4A1 CD19 CD79A CR2 IGKC PAX5 NA NA NA NA 0,96232531 0,9706199

7 MS4A1 CD79A FCRL2 BANK1 IGKC PAX5 CD22 NA NA NA 0,97785227 0,9705869

5 CD19 CD79A CR2 PAX5 CD22 NA NA NA NA NA 0,92181348 0,9701506

2 CD19 CR2 NA NA NA NA NA NA NA NA 0,89180868 0,9701480

2 CD19 PAX5 NA NA NA NA NA NA NA NA 0,79165949 0,9701230

3 FC L2 IGKC PAX5 NA NA NA NA NA NA NA 0,86181803 0,9700649

5 MS4A1 CD79A CR2 BANK1 IGKC NA NA NA NA NA 0,96249088 0,9700155

4 MS4A1 CD79A CR2 FCRL2 NA NA NA NA NA NA 0,95546463 0,9698756

3 CD19 IGKC PAX5 NA NA NA NA NA NA NA 0,88029201 0,9698725

2 MS4A1 IGKC NA NA NA NA NA NA NA NA 0,89417939 0,9698453

5 CD79A CR2 FCRL2 PAX5 CD22 NA NA NA NA NA 0,91699959 0,9697320

6 MS4A1 CD19 CD79A BANK1 IGKC PAX5 NA NA NA NA 0,96800436 0,9697295

6 MS4A1 CD79A CR2 IGKC PAX5 CD22 NA NA NA NA 0,96664528 0,9697229

5 CD19 CD79A BANK1 PAX5 CD22 NA NA NA NA NA 0,94019805 0,9696719

4 MS4A1 CD79A CR2 CD22 NA NA NA NA NA NA 0,95441585 0,9695686

6 MS4A1 CD19 CD79A FCRL2 PAX5 CD22 NA NA NA NA 0,95575629 0,9695685

7 MS4A1 CD19 CD79A CR2 FCRL2 IGKC CD22 NA NA NA 0,96728341 0,9694744

6 MS4A1 CD79A CR2 FCRL2 IGKC PAX5 NA NA NA NA 0,96005782 0,9694662

6 CD19 CD79A CR2 FCRL2 BANK1 IGKC NA NA NA NA 0,95081491 0,9692402

4 MS4A1 CD79A FCRL2 BANK1 NA NA NA NA NA NA 0,96411787 0,9690819

5 CD79A FCRL2 BANK1 PAX5 CD22 NA NA NA NA NA 0,9349252 0,9689293

5 CD79A CR2 BANK1 IGKC PAX5 NA NA NA NA NA 0,94847687 0,9689238

7 MS4A1 CD19 CD79A FCRL2 BANK1 IGKC CD22 NA NA NA 0,97205676 0,9688869

4 MS4A1 CD79A BANK1 CD22 NA NA NA NA NA NA 0,96690309 0,9688397

6 CD19 CD79A CR2 BANK1 IGKC CD22 NA NA NA NA 0,95895669 0,968835

6 MS4A1 CD79A BANK1 IGKC PAX5 CD22 NA NA NA NA 0,97344244 0,9687482

5 CD19 CD79A CR2 FCRL2 PAX5 NA NA NA NA NA 0,92455066 0,9685485

6 MS4A1 CD79A FCRL2 BANK1 IGKC PAX5 NA NA NA NA 0,96509234 0,9685351

5 CD19 CD79A FCRL2 BANK1 PAX5 NA NA NA NA NA 0,93920754 0,9684559

6 CD79A C 2 FCRL2 BANK1 IGKC CD22 NA NA NA NA 0,95576899 0,9683364

3 CD79A CR2 BANK1 NA NA NA NA NA NA NA 0,93161313 0,9681209

4 CD19 FCRL2 IGKC CD22 NA NA NA NA NA NA 0,89648348 0,9680999

2 CD19 CD22 NA NA NA NA NA NA NA NA 0,80950487 0,9680532

5 MS4A1 CD19 CD79A PAX5 CD22 NA NA NA NA NA 0,95018765 0,9679257

5 MS4A1 CD79A FCRL2 PAX5 CD22 NA NA NA NA NA 0,94844566 0,9674904

7 CD19 CD79A CR2 FCRL2 IGKC PAX5 CD22 NA NA NA 0,95298142 0,9674839

6 MS4A1 CD19 CD79A CR2 FCRL2 IGKC NA NA NA NA 0,95781313 0,9673843

4 CD79A CR2 PAX5 CD22 NA NA NA NA NA NA 0,90029962 0,9672841

7 CD19 CD79A FCRL2 BANK1 IGKC PAX5 CD22 NA NA NA 0,95993342 0,9669742

6 MS4A1 CD19 CD79A CR2 IGKC CD22 NA NA NA NA 0,96421671 0,966945

6 MS4A1 CD19 CD79A FCRL2 BANK1 IGKC NA NA NA NA 0,96075536 0,9668664

6 MS4A1 CD79A CR2 FCRL2 IGKC CD22 NA NA NA NA 0,96252164 0,9667513

5 MS4A1 CD19 CD79A FCRL2 PAX5 NA NA NA NA NA 0,95046498 0,9666479

5 MS4A1 CD79A CR2 IGKC PAX5 NA NA NA NA NA 0,95408652 0,9666347

4 CD19 CD79A BANK1 PAX5 NA NA NA NA NA NA 0,93080338 0,9665600

6 MS4A1 CD19 CD79A BANK1 IGKC CD22 NA NA NA NA 0,96874913 0,9665095

4 CD79A BANK1 PAX5 CD22 NA NA NA NA NA NA 0,91934165 0,9664909

4 CD19 CD79A CR2 PAX5 NA NA NA NA NA NA 0,91497037 0,9664370

5 CD19 CD79A CR2 BANK1 IGKC NA NA NA NA NA 0,94553432 0,9664174

5 CD19 CD79A FCRL2 BANK1 CD22 NA NA NA NA NA 0,94270097 0,9663346

2 IGKC PAX5 NA NA NA NA NA NA NA NA 0,82114181 0,966309

5 CD19 CD79A CR2 FCRL2 CD22 NA NA NA NA NA 0,92981325 0,9663038

6 MS4A1 CD79A FCRL2 BANK1 IGKC CD22 NA NA NA NA 0,96623323 0,9660957

3 FC L2 IGKC CD22 NA NA NA NA NA NA NA 0,85302786 0,9660527

2 CD19 FCRL2 NA NA NA NA NA NA NA NA 0,87512244 0,966019

5 MS4A1 CD79A BANK1 IGKC PAX5 NA NA NA NA NA 0,95870064 0,9657648

7 MS4A1 CD19 CD79A FCRL2 IGKC PAX5 CD22 NA NA NA 0,96433433 0,9656698

4 CD79A CR2 FCRL2 PAX5 NA NA NA NA NA NA 0,90618535 0,9652820

6 CD19 CD79A CR2 IGKC PAX5 CD22 NA NA NA NA 0,94768795 0,965275

5 CD79A CR2 FCRL2 BANK1 IGKC NA NA NA NA NA 0,93960271 0,9652728

6 CD79A CR2 FCRL2 IGKC PAX5 CD22 NA NA NA NA 0,94486592 0,9650184

4 CD79A FCRL2 BANK1 PAX5 NA NA NA NA NA NA 0,92016058 0,9650161

6 CD19 CD79A BANK1 IGKC PAX5 CD22 NA NA NA NA 0,95456375 0,96481

5 CD79A CR2 BANK1 IGKC CD22 NA NA NA NA NA 0,94922608 0,9646891

6 CD19 CD79A CR2 FCRL2 IGKC PAX5 NA NA NA NA 0,94089451 0,9645940

5 MS4A1 CD19 CD79A FCRL2 CD22 NA NA NA NA NA 0,95862731 0,9645748

6 CD79A FCRL2 BANK1 IGKC PAX5 CD22 NA NA NA NA 0,95090436 0,9643761

4 MS4A1 CD79A PAX5 CD22 NA NA NA NA NA NA 0,93733797 0,9643742

6 CD19 CD79A FCRL2 BANK1 IGKC PAX5 NA NA NA NA 0,94569477 0,9642647

3 MS4A1 CD79A BANK1 NA NA NA NA NA NA NA 0,95845726 0,9641119

4 MS4A1 CD19 CD79A PAX5 NA NA NA NA NA NA 0,94418505 0,96383

3 MS4A1 CD79A CR2 NA NA NA NA NA NA NA 0,95047375 0,9637481

3 CD19 FCRL2 IGKC NA NA NA NA NA NA NA 0,86642719 0,9636592

5 MS4A1 CD19 CD79A CR2 IGKC NA NA NA NA NA 0,95350448 0,9636139

5 MS4A1 CD19 CD79A BANK1 IGKC NA NA NA NA NA 0,955841 0,9634497

6 MS4A1 CD19 CD79A IGKC PAX5 CD22 NA NA NA NA 0,95967772 0,9630632

5 MS4A1 CD79A CR2 FCRL2 IGKC NA NA NA NA NA 0,94976617 0,962964

6 MS4A1 CD79A FCRL2 IGKC PAX5 CD22 NA NA NA NA 0,95763319 0,9628731

3 CD19 IGKC CD22 NA NA NA NA NA NA NA 0,87319211 0,9628152

4 MS4A1 CD79A FCRL2 PAX5 NA NA NA NA NA NA 0,93924174 0,9628118

4 CD79A CR2 FCRL2 CD22 NA NA NA NA NA NA 0,91862521 0,9627730

4 CD19 CD79A BANK1 CD22 NA NA NA NA NA NA 0,93785151 0,9627417

4 CD79A FCRL2 BANK1 CD22 NA NA NA NA NA NA 0,92981775 0,9626733

5 MS4A1 CD79A FCRL2 BANK1 IGKC NA NA NA NA NA 0,9508874 0,9625703

6 MS4A1 CD19 CD79A FCRL2 IGKC PAX5 NA NA NA NA 0,95280004 0,9624925

5 MS4A1 CD79A CR2 IGKC CD22 NA NA NA NA NA 0,95720343 0,9623303

4 CD19 CD79A FCRL2 BANK1 NA NA NA NA NA NA 0,93711341 0,9623081

5 MS4A1 CD79A BANK1 IGKC CD22 NA NA NA NA NA 0,96022713 0,9620787

4 CD19 CD79A CR2 CD22 NA NA NA NA NA NA 0,92397341 0,9619783

6 CD19 CD79A CR2 FCRL2 IGKC CD22 NA NA NA NA 0,93960472 0,9615979

6 CD19 CD79A FCRL2 BANK1 IGKC CD22 NA NA NA NA 0,94253209 0,9615936

4 CD19 CD79A CR2 FCRL2 NA NA NA NA NA NA 0,92823933 0,9613235

5 CD79A CR2 IGKC PAX5 CD22 NA NA NA NA NA 0,93603227 0,9612682

5 CD19 CD79A CR2 IGKC PAX5 NA NA NA NA NA 0,9337243 0,9611551

5 CD19 CD79A BANK1 IGKC PAX5 NA NA NA NA NA 0,93796735 0,9610414

5 CD79A BANK1 IGKC PAX5 CD22 NA NA NA NA NA 0,94144229 0,9608142

4 MS4A1 CD79A FCRL2 CD22 NA NA NA NA NA NA 0,95508562 0,9605395

5 CD19 CD79A FCRL2 PAX5 CD22 NA NA NA NA NA 0,90773872 0,9605107

5 CD79A CR2 FCRL2 IGKC PAX5 NA NA NA NA NA 0,92814666 0,9604817

3 CD79A BANK1 PAX5 NA NA NA NA NA NA NA 0,89934544 0,9602341

5 CD79A FCRL2 BANK1 IGKC PAX5 NA NA NA NA NA 0,93100971 0,960185

4 MS4A1 CD19 CD79A CD22 NA NA NA NA NA NA 0,95626558 0,9600201

6 MS4A1 CD19 CD79A FCRL2 IGKC CD22 NA NA NA NA 0,95264669 0,9598100

3 CD79A CR2 PAX5 NA NA NA NA NA NA NA 0,88600241 0,9596869

4 MS4A1 CD19 CD79A FCRL2 NA NA NA NA NA NA 0,9568748 0,9595752

4 CD79A CR2 BANK1 IGKC NA NA NA NA NA NA 0,9300985 0,9591866

5 MS4A1 CD79A IGKC PAX5 CD22 NA NA NA NA NA 0,94987129 0,9586849

5 MS4A1 CD19 CD79A IGKC PAX5 NA NA NA NA NA 0,94641501 0,9584915

2 FC L2 IGKC NA NA NA NA NA NA NA NA 0,8017488 0,9581030

5 MS4A1 CD79A FCRL2 IGKC PAX5 NA NA NA NA NA 0,94193109 0,9580288

6 CD19 CD79A FCRL2 IGKC PAX5 CD22 NA NA NA NA 0,93014867 0,9572302

5 CD79A FC L2 BANK1 IGKC CD22 NA NA NA NA NA 0,92752808 0,9571672

5 CD79A CR2 FCRL2 IGKC CD22 NA NA NA NA NA 0,92739378 0,9570227

5 CD19 CD79A FCRL2 BANK1 IGKC NA NA NA NA NA 0,92484191 0,9569885

5 CD19 CD79A BANK1 IGKC CD22 NA NA NA NA NA 0,93460988 0,956877

3 MS4A1 CD79A PAX5 NA NA NA NA NA NA NA 0,92549158 0,9564948

4 CD79A FCRL2 PAX5 CD22 NA NA NA NA NA NA 0,87924174 0,9564868

5 CD19 CD79A CR2 FCRL2 IGKC NA NA NA NA NA 0,92509771 0,9563604

5 CD19 CD79A CR2 IGKC CD22 NA NA NA NA NA 0,93265817 0,95621

4 MS4A1 CD79A BANK1 IGKC NA NA NA NA NA NA 0,94220342 0,9560521

2 IGKC CD22 NA NA NA NA NA NA NA NA 0,80634342 0,9559425

3 CD19 CD79A BANK1 NA NA NA NA NA NA NA 0,93305792 0,9559141

4 CD19 CD79A PAX5 CD22 NA NA NA NA NA NA 0,89086699 0,9557130

3 CD79A BANK1 CD22 NA NA NA NA NA NA NA 0,91487251 0,9556657

4 MS4A1 CD79A CR2 IGKC NA NA NA NA NA NA 0,94235709 0,9553101

3 CD79A FCRL2 BANK1 NA NA NA NA NA NA NA 0,91711174 0,9551969

5 MS4A1 CD79A FCRL2 IGKC CD22 NA NA NA NA NA 0,94248612 0,9549958

5 MS4A1 CD19 CD79A FCRL2 IGKC NA NA NA NA NA 0,93891904 0,9543879

4 CD79A BANK1 IGKC PAX5 NA NA NA NA NA NA 0,91749719 0,9542613

5 MS4A1 CD19 CD79A IGKC CD22 NA NA NA NA NA 0,94655998 0,9542612

3 CD79A CR2 CD22 NA NA NA NA NA NA NA 0,90521944 0,9540931

4 CD79A CR2 IGKC PAX5 NA NA NA NA NA NA 0,91608093 0,9538067

3 CD79A CR2 FCRL2 NA NA NA NA NA NA NA 0,91479532 0,9533681

4 CD19 CD79A FCRL2 PAX5 NA NA NA NA NA NA 0,8974084 0,9530177

5 CD79A FCRL2 IGKC PAX5 CD22 NA NA NA NA NA 0,91275391 0,9526355

3 CD19 CD79A CR2 NA NA NA NA NA NA NA 0,92464784 0,9524619

2 CD19 IGKC NA NA NA NA NA NA NA NA 0,83388936 0,9519819

3 MS4A1 CD79A CD22 NA NA NA NA NA NA NA 0,94821999 0,951933

5 CD19 CD79A IGKC PAX5 CD22 NA NA NA NA NA 0,91958419 0,9518976

3 MS4A1 CD79A FCRL2 NA NA NA NA NA NA NA 0,95112497 0,9514485

3 MS4A1 CD19 CD79A NA NA NA NA NA NA NA 0,95592077 0,9509326

4 MS4A1 CD79A IGKC PAX5 NA NA NA NA NA NA 0,93129778 0,9508918

5 CD19 CD79A FCRL2 IGKC PAX5 NA NA NA NA NA 0,91174455 0,9506297

4 CD19 CD79A FCRL2 CD22 NA NA NA NA NA NA 0,90173912 0,9505905

4 CD79A FCRL2 BANK1 IGKC NA NA NA NA NA NA 0,90184624 0,9495349

4 CD79A BANK1 IGKC CD22 NA NA NA NA NA NA 0,91325141 0,9493474

4 CD19 CD79A BANK1 IGKC NA NA NA NA NA NA 0,91357035 0,9492620

3 CD79A PAX5 CD22 NA NA NA NA NA NA NA 0,84157134 0,9481148

4 CD79A CR2 FCRL2 IGKC NA NA NA NA NA NA 0,90652648 0,9480406

4 CD79A CR2 IGKC CD22 NA NA NA NA NA NA 0,91532533 0,9477695

5 CD19 CD79A FCRL2 IGKC CD22 NA NA NA NA NA 0,90567888 0,9472967

4 CD19 CD79A CR2 IGKC NA NA NA NA NA NA 0,91560673 0,9468900

4 MS4A1 CD79A FCRL2 IGKC NA NA NA NA NA NA 0,92314232 0,9460955

4 MS4A1 CD79A IGKC CD22 NA NA NA NA NA NA 0,93199211 0,9458896

4 MS4A1 CD19 CD79A IGKC NA NA NA NA NA NA 0,93052407 0,9449954

3 CD79A FCRL2 PAX5 NA NA NA NA NA NA NA 0,85683343 0,9444418

4 CD79A IGKC PAX5 CD22 NA NA NA NA NA NA 0,89474296 0,9441537

3 CD19 CD79A PAX5 NA NA NA NA NA NA NA 0,87762003 0,9428946

4 CD79A FCRL2 IGKC PAX5 NA NA NA NA NA NA 0,88594471 0,9425463

1 C 2 NA NA NA NA NA NA NA NA NA 0,80302115 0,9423708

3 CD79A FCRL2 CD22 NA NA NA NA NA NA NA 0,87176333 0,9418189

4 CD19 CD79A IGKC PAX5 NA NA NA NA NA NA 0,89750387 0,9412978

2 CD79A BANK1 NA NA NA NA NA NA NA NA 0,89852152 0,939077

4 CD79A FCRL2 IGKC CD22 NA NA NA NA NA NA 0,87794757 0,9386997

3 CD19 CD79A CD22 NA NA NA NA NA NA NA 0,88768 0,9376259

4 CD19 CD79A IGKC CD22 NA NA NA NA NA NA 0,89031085 0,935564

3 CD19 CD79A FCRL2 NA NA NA NA NA NA NA 0,89918968 0,9353876

4 CD19 CD79A FCRL2 IGKC NA NA NA NA NA NA 0,88203976 0,9349594

3 CD79A BANK1 IGKC NA NA NA NA NA NA NA 0,88153346 0,9348335

1 CD19 NA NA NA NA NA NA NA NA NA 0,86421676 0,9313369

2 MS4A1 CD79A NA NA NA NA NA NA NA NA 0,94490507 0,9303734

3 CD79A CR2 IGKC NA NA NA NA NA NA NA 0,88980211 0,9285792

3 MS4A1 CD79A IGKC NA NA NA NA NA NA NA 0,90861222 0,9283735

2 CD79A CR2 NA NA NA NA NA NA NA NA 0,90335602 0,9282439

3 CD79A IGKC PAX5 NA NA NA NA NA NA NA 0,8613556 0,9256654

2 CD79A PAX5 NA NA NA NA NA NA NA NA 0,805975 0,9225253

1 IGKC NA NA NA NA NA NA NA NA NA 0,73550985 0,9211047

3 CD79A IGKC CD22 NA NA NA NA NA NA NA 0,85056591 0,9186555

3 CD79A FCRL2 IGKC NA NA NA NA NA NA NA 0,8418475 0,9177343

2 CD79A CD22 NA NA NA NA NA NA NA NA 0,83033871 0,9160798

2 CD79A FCRL2 NA NA NA NA NA NA NA NA 0,86279721 0,9124416

3 CD19 CD79A IGKC NA NA NA NA NA NA NA 0,86119079 0,9108004

2 CD19 CD79A NA NA NA NA NA NA NA NA 0,89100279 0,899660

2 CD79A IGKC NA NA NA NA NA NA NA NA 0,80413697 0,8673564

1 CD79A NA NA NA NA NA NA NA NA NA 0,82573471 0,8037471

Combination of genes for identification of cytotoxic lymphocytes

Figure imgf000067_0001

Figure imgf000068_0001

Figure imgf000069_0001

Figure imgf000070_0001

Figure imgf000071_0001

KLRC4-KLRK1 KLRC1 ///

5 /// KLRK1 CD8A KLRD1 KLRC2 KLRC4 NA NA NA NA NA 0,95876773 NA

KLRC4-KLRK1

5 /// KLRK1 CD8A KLRD1 GNLY KLRC3 NA NA NA NA NA 0,95873982 NA

KLRC4-KLRK1 KLRC1 ///

4 /// KLRK1 CD8A KLRD1 KLRC2 NA NA NA NA NA NA 0,95845319 NA

KLRC4-KLRK1 KLRC1 ///

5 /// KLRK1 CD8A GNLY KLRC2 EOM ES NA NA NA NA NA 0,95832321 NA

KLRC4-KLRK1

6 /// KLRK1 KLRD1 GNLY EOM ES KLRC3 KLRC4 NA NA NA NA 0,95799553 NA

KLRC1 ///

5 CD8A KLRD1 KLRC2 EOM ES FGFBP2 NA NA NA NA NA 0,9578116 NA

KLRC1 ///

5 CD8A KLRD1 KLRC2 EOM ES KLRC3 NA NA NA NA NA 0,95766313 NA

KLRC4-KLRK1 KLRC1 ///

5 /// KLRK1 CD8A GNLY KLRC2 FGFBP2 NA NA NA NA NA 0,95731301 NA

KLRC4-KLRK1 KLRC1 ///

6 /// KLRK1 CD8A KLRC2 EOM ES KLRC4 FGFBP2 NA NA NA NA 0,95730014 NA

KLRC4-KLRK1

6 /// KLRK1 CD8A GNLY EOM ES KLRC3 KLRC4 NA NA NA NA 0,95614194 NA

6 CD8A KLRD1 GNLY EOM ES KLRC3 KLRC4 NA NA NA NA 0,95605541 NA

KLRC4-KLRK1

6 /// KLRK1 CD8A KLRD1 GNLY EOM ES KLRC3 NA NA NA NA 0,95588134 NA

KLRC4-KLRK1

6 /// KLRK1 KLRD1 GNLY EOM ES KLRC3 FGFBP2 NA NA NA NA 0,95586183 NA

KLRC4-KLRK1 KLRC1 ///

5 /// KLRK1 CD8A GNLY KLRC2 KLRC4 NA NA NA NA NA 0,95527409 NA

KLRC4-KLRK1

5 /// KLRK1 CD8A GNLY KLRC3 KLRC4 NA NA NA NA NA 0,95488811 NA

KLRC4-KLRK1

4 /// KLRK1 CD8A KLRD1 KLRC3 NA NA NA NA NA NA 0,95482071 NA

KLRC1 ///

6 CD8A KLRD1 KLRC2 EOM ES KLRC3 KLRC4 NA NA NA NA 0,9545937 NA

KLRC4-KLRK1

5 /// KLRK1 CD8A KLRD1 KLRC3 KLRC4 NA NA NA NA NA 0,95458805 NA

KLRC4-KLRK1 KLRC1 ///

7 /// KLRK1 KLRD1 GNLY KLRC2 EOM ES KLRC3 KLRC4 NA NA NA 0,95454626 NA

5 CD8A KLRD1 GNLY KLRC3 KLRC4 NA NA NA NA NA 0,95421526 NA

KLRC4-KLRK1

6 /// KLRK1 CD8A GNLY EOM ES KLRC3 FGFBP2 NA NA NA NA 0,95418307 NA

KLRC1 ///

6 CD8A KLRD1 GNLY KLRC2 KLRC3 FGFBP2 NA NA NA NA 0,95413081 NA

KLRC4-KLRK1

6 /// KLRK1 CD8A GNLY KLRC3 KLRC4 FGFBP2 NA NA NA NA 0,95401006 NA

KLRC1 ///

5 CD8A KLRD1 GNLY KLRC2 KLRC4 NA NA NA NA NA 0,95392777 NA

KLRC1 ///

5 CD8A KLRD1 GNLY KLRC2 EOM ES NA NA NA NA NA 0,95346371 NA

6 CD8A KLRD1 GNLY KLRC3 KLRC4 FGFBP2 NA NA NA NA 0,9527573 NA

KLRC4-KLRK1

6 /// KLRK1 CD8A KLRD1 KLRC3 KLRC4 FGFBP2 NA NA NA NA 0,95265409 NA

KLRC1 ///

5 CD8A GNLY KLRC2 EOM ES KLRC3 NA NA NA NA NA 0,95262131 NA

KLRC1 ///

7 CD8A KLRD1 GNLY KLRC2 KLRC3 KLRC4 FGFBP2 NA NA NA 0,95260744 NA

KLRC1 ///

5 CD8A GNLY KLRC2 EOM ES KLRC4 NA NA NA NA NA 0,95225292 NA

KLRC1 ///

6 CD8A GNLY KLRC2 EOM ES KLRC3 KLRC4 NA NA NA NA 0,95221043 NA

KLRC4-KLRK1

6 /// KLRK1 CD8A KLRD1 EOM ES KLRC3 KLRC4 NA NA NA NA 0,95217913 NA

KLRC4-KLRK1 KLRC1 ///

5 /// KLRK1 CD8A KLRC2 EOM ES FGFBP2 NA NA NA NA NA 0,95213968 NA

KLRC4-KLRK1 KLRC1 ///

4 /// KLRK1 CD8A GNLY KLRC2 NA NA NA NA NA NA 0,9518934 NA

KLRC4-KLRK1 KLRC1 ///

6 /// KLRK1 CD8A KLRC2 EOM ES KLRC3 FGFBP2 NA NA NA NA 0,95182312 NA

KLRC4-KLRK1

5 /// KLRK1 KLRD1 GNLY EOM ES KLRC3 NA NA NA NA NA 0,95181965 NA

KLRC4-KLRK1 KLRC1 ///

6 /// KLRK1 CD8A GNLY KLRC2 KLRC3 FGFBP2 NA NA NA NA 0,95176426 NA

KLRC4-KLRK1

6 /// KLRK1 CD8A KLRD1 EOM ES KLRC3 FGFBP2 NA NA NA NA 0,95175822 NA

KLRC4-KLRK1 KLRC1 ///

6 /// KLRK1 CD8A KLRD1 KLRC2 KLRC3 FGFBP2 NA NA NA NA 0,95162164 NA

KLRC4-KLRK1

4 /// KLRK1 CD8A GNLY KLRC3 NA NA NA NA NA NA 0,95139915 NA

KLRC4-KLRK1 KLRC1 ///

6 /// KLRK1 GNLY KLRC2 EOM ES KLRC4 FGFBP2 NA NA NA NA 0,95092297 NA

KLRC1 ///

4 CD8A KLRD1 KLRC2 KLRC4 NA NA NA NA NA NA 0,95064809 NA

KLRC4-KLRK1 KLRC1 ///

6 /// KLRK1 KLRD1 KLRC2 EOM ES KLRC4 FGFBP2 NA NA NA NA 0,95042641 NA

KLRC1 ///

5 CD8A KLRD1 GNLY KLRC2 FGFBP2 NA NA NA NA NA 0,95022938 NA

KLRC4-KLRK1

5 /// KLRK1 CD8A KLRD1 KLRC3 FGFBP2 NA NA NA NA NA 0,95013278 NA

KLRC4-KLRK1 KLRC1 ///

5 /// KLRK1 KLRD1 KLRC2 EOM ES FGFBP2 NA NA NA NA NA 0,95010108 NA

KLRC1 ///

6 KLRD1 GNLY KLRC2 EOM ES KLRC4 FGFBP2 NA NA NA NA 0,95005044 NA

KLRC1 ///

4 CD8A KLRD1 KLRC2 EOM ES NA NA NA NA NA NA 0,94979674 NA

4 CD8A KLRD1 KLRC3 KLRC4 NA NA NA NA NA NA 0,94943442 NA

3 CD8A KLRD1 KLRC3 NA NA NA NA NA NA NA 0,94940909 NA

KLRC1 ///

3 CD8A KLRD1 KLRC2 NA NA NA NA NA NA NA 0,94905898 NA

KLRC4-KLRK1

5 /// KLRK1 CD8A GNLY KLRC3 FGFBP2 NA NA NA NA NA 0,94892685 NA

6 CD8A KLRD1 GNLY EOM ES KLRC3 FGFBP2 NA NA NA NA 0,94886494 NA

KLRC1 ///

5 CD8A GNLY KLRC2 EOM ES FGFBP2 NA NA NA NA NA 0,94871788 NA

KLRC1 ///

5 CD8A KLRD1 GNLY KLRC2 KLRC3 NA NA NA NA NA 0,94825083 NA

KLRC4-KLRK1 KLRC1 ///

5 /// KLRK1 CD8A KLRC2 EOM ES KLRC4 NA NA NA NA NA 0,9482095 NA

KLRC4-KLRK1 KLRC1 ///

5 /// KLRK1 GNLY KLRC2 EOM ES FGFBP2 NA NA NA NA NA 0,94801869 NA

KLRC1 ///

5 CD8A KLRD1 KLRC2 KLRC4 FGFBP2 NA NA NA NA NA 0,94757578 NA

KLRC4-KLRK1 KLRC1 ///

7 /// KLRK1 CD8A KLRC2 EOM ES KLRC3 KLRC4 FGFBP2 NA NA NA 0,94713576 NA

KLRC4-KLRK1 KLRC1 ///

7 /// KLRK1 CD8A GNLY KLRC2 KLRC3 KLRC4 FGFBP2 NA NA NA 0,94701027 NA

KLRC4-KLRK1 KLRC1 ///

4 /// KLRK1 KLRD1 KLRC2 EOM ES NA NA NA NA NA NA 0,9460037 NA

KLRC1 ///

6 CD8A KLRD1 GNLY KLRC2 KLRC3 KLRC4 NA NA NA NA 0,94595766 NA

KLRC4-KLRK1

5 /// KLRK1 CD8A GNLY EOM ES KLRC3 NA NA NA NA NA 0,94571546 NA

KLRC4-KLRK1 KLRC1 ///

5 /// KLRK1 GNLY KLRC2 EOM ES KLRC4 NA NA NA NA NA 0,94545099 NA

KLRC4-KLRK1 KLRC1 ///

5 /// KLRK1 CD8A GNLY KLRC2 KLRC3 NA NA NA NA NA 0,9453507 NA

KLRC1 ///

5 KLRD1 GNLY KLRC2 EOM ES KLRC4 NA NA NA NA NA 0,94489884 NA

KLRC4-KLRK1 KLRC1 ///

5 /// KLRK1 CD8A KLRD1 KLRC2 KLRC3 NA NA NA NA NA 0,94487618 NA

KLRC4-KLRK1 KLRC1 ///

5 /// KLRK1 KLRD1 KLRC2 EOM ES KLRC4 NA NA NA NA NA 0,94482757 NA

6 CD8A KLRD1 EOM ES KLRC3 KLRC4 FGFBP2 NA NA NA NA 0,94443494 NA

KLRC4-KLRK1 KLRC1 ///

7 /// KLRK1 CD8A KLRD1 KLRC2 KLRC3 KLRC4 FGFBP2 NA NA NA 0,94437684 NA

KLRC1 ///

4 CD8A KLRD1 GNLY KLRC2 NA NA NA NA NA NA 0,94430067 NA

KLRC4-KLRK1 KLRC1 ///

4 /// KLRK1 GNLY KLRC2 EOM ES NA NA NA NA NA NA 0,94337306 NA

KLRC1 ///

4 CD8A KLRD1 KLRC2 FGFBP2 NA NA NA NA NA NA 0,9431408 NA

KLRC4-KLRK1 KLRC1 ///

5 /// KLRK1 CD8A KLRC2 EOM ES KLRC3 NA NA NA NA NA 0,94310061 NA

KLRC4-KLRK1 KLRC1 ///

4 /// KLRK1 CD8A KLRC2 EOM ES NA NA NA NA NA NA 0,94305305 NA

KLRC4-KLRK1

5 /// KLRK1 CD8A KLRD1 EOM ES KLRC3 NA NA NA NA NA 0,94234637 NA

4 CD8A KLRD1 GNLY KLRC3 NA NA NA NA NA NA 0,94228605 NA

KLRC1 ///

6 KLRD1 GNLY KLRC2 EOM ES KLRC3 FGFBP2 NA NA NA NA 0,94200001 NA

6 CD8A GNLY EOM ES KLRC3 KLRC4 FGFBP2 NA NA NA NA 0,9419966 NA

5 CD8A KLRD1 EOM ES KLRC3 KLRC4 NA NA NA NA NA 0,9414498 NA

KLRC1 ///

5 KLRD1 GNLY KLRC2 EOM ES FGFBP2 NA NA NA NA NA 0,94112072 NA

5 CD8A KLRD1 GNLY KLRC3 FGFBP2 NA NA NA NA NA 0,94043615 NA

KLRC1 ///

4 CD8A GNLY KLRC2 EOM ES NA NA NA NA NA NA 0,94015008 NA

5 CD8A KLRD1 GNLY EOM ES KLRC3 NA NA NA NA NA 0,9400655 NA

KLRC1 ///

7 KLRD1 GNLY KLRC2 EOM ES KLRC3 KLRC4 FGFBP2 NA NA NA 0,93976065 NA

KLRC4-KLRK1 KLRC1 ///

6 /// KLRK1 CD8A GNLY KLRC2 KLRC3 KLRC4 NA NA NA NA 0,93959275 NA

KLRC4-KLRK1 KLRC1 ///

6 /// KLRK1 GNLY KLRC2 EOM ES KLRC3 FGFBP2 NA NA NA NA 0,93890904 NA

KLRC4-KLRK1 KLRC1 ///

3 /// KLRK1 CD8A KLRC2 NA NA NA NA NA NA NA 0,9388211 NA

5 CD8A GNLY EOM ES KLRC3 KLRC4 NA NA NA NA NA 0,93817122 NA

KLRC4-KLRK1 KLRC1 ///

6 /// KLRK1 KLRD1 GNLY KLRC2 KLRC4 FGFBP2 NA NA NA NA 0,93764544 NA

KLRC4-KLRK1 KLRC1 ///

6 /// KLRK1 CD8A KLRC2 EOM ES KLRC3 KLRC4 NA NA NA NA 0,93760979 NA

KLRC4-KLRK1 KLRC1 ///

5 /// KLRK1 KLRD1 GNLY KLRC2 FGFBP2 NA NA NA NA NA 0,93632167 NA

KLRC4-KLRK1 KLRC1 ///

6 /// KLRK1 CD8A KLRD1 KLRC2 KLRC3 KLRC4 NA NA NA NA 0,9362404 NA

KLRC1 ///

5 KLRD1 GNLY KLRC2 EOM ES KLRC3 NA NA NA NA NA 0,93613552 NA

KLRC1 ///

4 KLRD1 GNLY KLRC2 EOM ES NA NA NA NA NA NA 0,93600922 NA

KLRC1 ///

5 CD8A GNLY KLRC2 KLRC4 FGFBP2 NA NA NA NA NA 0,93593321 NA

KLRC4-KLRK1 KLRC1 ///

4 /// KLRK1 CD8A KLRC2 FGFBP2 NA NA NA NA NA NA 0,9358559 NA

KLRC4-KLRK1

4 /// KLRK1 KLRD1 GNLY KLRC3 NA NA NA NA NA NA 0,93551127 NA

KLRC1 ///

5 CD8A KLRC2 EOM ES KLRC4 FGFBP2 NA NA NA NA NA 0,93537971 NA

KLRC1 ///

4 CD8A GNLY KLRC2 KLRC4 NA NA NA NA NA NA 0,93534916 NA

KLRC4-KLRK1 KLRC1 ///

6 /// KLRK1 KLRD1 KLRC2 EOM ES KLRC3 FGFBP2 NA NA NA NA 0,93493089 NA

KLRC4-KLRK1

7 /// KLRK1 CD8A KLRD1 GNLY EOM ES KLRC4 FGFBP2 NA NA NA 0,9342998 NA

KLRC4-KLRK1 KLRC1 ///

5 /// KLRK1 CD8A KLRC2 KLRC4 FGFBP2 NA NA NA NA NA 0,93392778 NA

4 CD8A GNLY KLRC3 KLRC4 NA NA NA NA NA NA 0,93382586 NA

KLRC4-KLRK1

6 /// KLRK1 CD8A KLRD1 GNLY KLRC4 FGFBP2 NA NA NA NA 0,93345576 NA

KLRC4-KLRK1 KLRC1 ///

4 /// KLRK1 CD8A KLRC2 KLRC4 NA NA NA NA NA NA 0,93336684 NA

KLRC4-KLRK1 KLRC1 ///

7 /// KLRK1 GNLY KLRC2 EOM ES KLRC3 KLRC4 FGFBP2 NA NA NA 0,93334678 NA

5 KLRD1 GNLY EOM ES KLRC3 KLRC4 NA NA NA NA NA 0,93327604 NA

KLRC4-KLRK1 KLRC1 ///

4 /// KLRK1 KLRD1 GNLY KLRC2 NA NA NA NA NA NA 0,93325023 NA

KLRC4-KLRK1

5 /// KLRK1 KLRD1 GNLY KLRC3 KLRC4 NA NA NA NA NA 0,93324448 NA

KLRC4-KLRK1

5 /// KLRK1 GNLY EOM ES KLRC3 KLRC4 NA NA NA NA NA 0,93318605 NA

KLRC4-KLRK1 KLRC1 ///

5 /// KLRK1 KLRD1 GNLY KLRC2 KLRC4 NA NA NA NA NA 0,93318068 NA

KLRC1 ///

6 KLRD1 GNLY KLRC2 EOM ES KLRC3 KLRC4 NA NA NA NA 0,93289695 NA

KLRC4-KLRK1

6 /// KLRK1 GNLY EOM ES KLRC3 KLRC4 FGFBP2 NA NA NA NA 0,9325665 NA

KLRC4-KLRK1 KLRC1 ///

5 /// KLRK1 GNLY KLRC2 EOM ES KLRC3 NA NA NA NA NA 0,93235864 NA

6 KLRD1 GNLY EOM ES KLRC3 KLRC4 FGFBP2 NA NA NA NA 0,93185897 NA

KLRC1 ///

4 CD8A KLRC2 EOM ES KLRC4 NA NA NA NA NA NA 0,93162891 NA

KLRC4-KLRK1

6 /// KLRK1 CD8A EOM ES KLRC3 KLRC4 FGFBP2 NA NA NA NA 0,93133114 NA

KLRC4-KLRK1

3 /// KLRK1 CD8A KLRC3 NA NA NA NA NA NA NA 0,93132789 NA

KLRC4-KLRK1

4 /// KLRK1 GNLY EOM ES KLRC3 NA NA NA NA NA NA 0,93001779 NA

5 CD8A KLRD1 KLRC3 KLRC4 FGFBP2 NA NA NA NA NA 0,92993556 NA

5 CD8A KLRD1 EOM ES KLRC3 FGFBP2 NA NA NA NA NA 0,92941475 NA

KLRC4-KLRK1

6 /// KLRK1 KLRD1 GNLY KLRC3 KLRC4 FGFBP2 NA NA NA NA 0,92863261 NA

KLRC1 ///

5 CD8A KLRD1 KLRC2 KLRC3 FGFBP2 NA NA NA NA NA 0,92824297 NA

KLRC1 ///

3 CD8A GNLY KLRC2 NA NA NA NA NA NA NA 0,92796656 NA

KLRC4-KLRK1 KLRC1 ///

5 /// KLRK1 KLRD1 KLRC2 EOM ES KLRC3 NA NA NA NA NA 0,92768814 NA

KLRC1 ///

4 CD8A GNLY KLRC2 FGFBP2 NA NA NA NA NA NA 0,92751963 NA

KLRC4-KLRK1

5 /// KLRK1 GNLY EOM ES KLRC3 FGFBP2 NA NA NA NA NA 0,92740346 NA

KLRC4-KLRK1

5 /// KLRK1 KLRD1 GNLY KLRC3 FGFBP2 NA NA NA NA NA 0,92710632 NA

KLRC1 ///

5 CD8A KLRC2 EOM ES KLRC3 FGFBP2 NA NA NA NA NA 0,92706217 NA

KLRC4-KLRK1 KLRC1 ///

7 /// KLRK1 KLRD1 KLRC2 EOM ES KLRC3 KLRC4 FGFBP2 NA NA NA 0,92699077 NA

KLRC1 ///

4 CD8A KLRD1 KLRC2 KLRC3 NA NA NA NA NA NA 0,92656799 NA

5 CD8A GNLY EOM ES KLRC3 FGFBP2 NA NA NA NA NA 0,92629821 NA

4 CD8A KLRD1 EOM ES KLRC3 NA NA NA NA NA NA 0,92601034 NA

KLRC4-KLRK1

5 /// KLRK1 CD8A EOM ES KLRC3 KLRC4 NA NA NA NA NA 0,92564162 NA

KLRC4-KLRK1

6 /// KLRK1 KLRD1 GNLY EOM ES KLRC4 FGFBP2 NA NA NA NA 0,92563658 NA

KLRC4-KLRK1 KLRC1 ///

6 /// KLRK1 GNLY KLRC2 EOM ES KLRC3 KLRC4 NA NA NA NA 0,92556369 NA

KLRC1 ///

4 CD8A KLRC2 EOM ES FGFBP2 NA NA NA NA NA NA 0,92543305 NA

3 CD8A GNLY KLRC3 NA NA NA NA NA NA NA 0,92522779 NA

KLRC4-KLRK1

5 /// KLRK1 KLRD1 EOM ES KLRC3 KLRC4 NA NA NA NA NA 0,92463756 NA

KLRC4-KLRK1

4 /// KLRK1 KLRD1 EOM ES KLRC3 NA NA NA NA NA NA 0,92461619 NA

KLRC4-KLRK1

5 /// KLRK1 CD8A KLRD1 GNLY KLRC4 NA NA NA NA NA 0,92397762 NA

KLRC4-KLRK1

6 /// KLRK1 KLRD1 EOM ES KLRC3 KLRC4 FGFBP2 NA NA NA NA 0,9239641 NA

KLRC1 ///

5 CD8A GNLY KLRC2 KLRC3 FGFBP2 NA NA NA NA NA 0,92364775 NA

KLRC1 ///

6 CD8A KLRC2 EOM ES KLRC3 KLRC4 FGFBP2 NA NA NA NA 0,92351616 NA

4 CD8A KLRD1 KLRC3 FGFBP2 NA NA NA NA NA NA 0,92254045 NA

5 CD8A GNLY KLRC3 KLRC4 FGFBP2 NA NA NA NA NA 0,92239823 NA

KLRC4-KLRK1

5 /// KLRK1 CD8A EOM ES KLRC3 FGFBP2 NA NA NA NA NA 0,92237424 NA

KLRC4-KLRK1

4 /// KLRK1 CD8A KLRC3 KLRC4 NA NA NA NA NA NA 0,92235538 NA

KLRC1 ///

3 CD8A KLRC2 EOM ES NA NA NA NA NA NA NA 0,92219311 NA

KLRC1 ///

4 CD8A KLRC2 EOM ES KLRC3 NA NA NA NA NA NA 0,92186156 NA

4 CD8A GNLY EOM ES KLRC3 NA NA NA NA NA NA 0,92172468 NA

KLRC4-KLRK1 KLRC1 ///

6 /// KLRK1 KLRD1 GNLY KLRC2 KLRC3 FGFBP2 NA NA NA NA 0,92169522 NA

KLRC1 ///

6 CD8A KLRD1 KLRC2 KLRC3 KLRC4 FGFBP2 NA NA NA NA 0,92122519 NA

4 KLRD1 GNLY EOM ES KLRC3 NA NA NA NA NA NA 0,92101993 NA

KLRC4-KLRK1

5 /// KLRK1 KLRD1 EOM ES KLRC3 FGFBP2 NA NA NA NA NA 0,92082444 NA

KLRC1 ///

4 CD8A GNLY KLRC2 KLRC3 NA NA NA NA NA NA 0,92050653 NA

KLRC1 ///

6 CD8A GNLY KLRC2 KLRC3 KLRC4 FGFBP2 NA NA NA NA 0,9204021 NA

KLRC4-KLRK1

6 /// KLRK1 CD8A GNLY EOM ES KLRC4 FGFBP2 NA NA NA NA 0,91921028 NA

KLRC4-KLRK1

6 /// KLRK1 CD8A KLRD1 GNLY EOM ES KLRC4 NA NA NA NA 0,91902403 NA

5 KLRD1 GNLY EOM ES KLRC3 FGFBP2 NA NA NA NA NA 0,91897104 NA

KLRC1 ///

4 KLRD1 KLRC2 EOM ES KLRC4 NA NA NA NA NA NA 0,9188339 NA

KLRC4-KLRK1

5 /// KLRK1 CD8A GNLY KLRC4 FGFBP2 NA NA NA NA NA 0,91865253 NA

KLRC4-KLRK1 KLRC1 ///

6 /// KLRK1 KLRD1 KLRC2 EOM ES KLRC3 KLRC4 NA NA NA NA 0,91812595 NA

KLRC1 ///

5 KLRD1 KLRC2 EOM ES KLRC4 FGFBP2 NA NA NA NA NA 0,91714826 NA

KLRC4-KLRK1

4 /// KLRK1 CD8A EOM ES KLRC3 NA NA NA NA NA NA 0,9170024 NA

KLRC4-KLRK1

5 /// KLRK1 KLRD1 GNLY EOM ES KLRC4 NA NA NA NA NA 0,9169599 NA

KLRC4-KLRK1

5 /// KLRK1 CD8A KLRD1 KLRC4 FGFBP2 NA NA NA NA NA 0,91684413 NA

Figure imgf000082_0001

KLRC4-KLRK1

5 /// KLRK1 CD8A KLRC3 KLRC4 FGFBP2 NA NA NA NA NA 0,9108215 NA

4 CD8A GNLY KLRC3 FGFBP2 NA NA NA NA NA NA 0,910677 NA

KLRC4-KLRK1

6 /// KLRK1 CD8A KLRD1 GNLY EOM ES FGFBP2 NA NA NA NA 0,90921946 NA

KLRC1 ///

3 CD8A KLRC2 KLRC4 NA NA NA NA NA NA NA 0,90911222 NA

KLRC4-KLRK1 KLRC1 ///

4 /// KLRK1 CD8A KLRC2 KLRC3 NA NA NA NA NA NA 0,90832511 NA

KLRC4-KLRK1 KLRC1 ///

3 /// KLRK1 KLRD1 KLRC2 NA NA NA NA NA NA NA 0,90807598 NA

6 CD8A KLRD1 GNLY EOM ES KLRC4 FGFBP2 NA NA NA NA 0,90780154 NA

KLRC4-KLRK1 KLRC1 ///

6 /// KLRK1 KLRD1 GNLY KLRC2 KLRC3 KLRC4 NA NA NA NA 0,90768374 NA

2 CD8A KLRC3 NA NA NA NA NA NA NA NA 0,90673128 NA

KLRC4-KLRK1

5 /// KLRK1 CD8A KLRD1 GNLY FGFBP2 NA NA NA NA NA 0,90638933 NA

KLRC4-KLRK1

5 /// KLRK1 CD8A GNLY EOM ES KLRC4 NA NA NA NA NA 0,90582226 NA

KLRC4-KLRK1 KLRC1 ///

3 /// KLRK1 KLRC2 EOM ES NA NA NA NA NA NA NA 0,90484148 NA

KLRC4-KLRK1

5 /// KLRK1 KLRD1 GNLY KLRC4 FGFBP2 NA NA NA NA NA 0,90481931 NA

KLRC4-KLRK1 KLRC1 ///

3 /// KLRK1 GNLY KLRC2 NA NA NA NA NA NA NA 0,90427726 NA

KLRC4-KLRK1 KLRC1 ///

6 /// KLRK1 CD8A KLRC2 KLRC3 KLRC4 FGFBP2 NA NA NA NA 0,90361268 NA

KLRC1 ///

3 GNLY KLRC2 EOM ES NA NA NA NA NA NA NA 0,90359784 NA

KLRC1 ///

4 GNLY KLRC2 EOM ES FGFBP2 NA NA NA NA NA NA 0,90348314 NA

KLRC4-KLRK1 KLRC1 ///

4 /// KLRK1 KLRC2 EOM ES FGFBP2 NA NA NA NA NA NA 0,90348017 NA

KLRC4-KLRK1

3 /// KLRK1 GNLY KLRC3 NA NA NA NA NA NA NA 0,90321755 NA

KLRC4-KLRK1 KLRC1 ///

5 /// KLRK1 KLRC2 EOM ES KLRC4 FGFBP2 NA NA NA NA NA 0,90228908 NA

KLRC4-KLRK1

3 /// KLRK1 KLRD1 KLRC3 NA NA NA NA NA NA NA 0,9017638 NA

5 CD8A KLRD1 GNLY KLRC4 FGFBP2 NA NA NA NA NA 0,90079834 NA

KLRC4-KLRK1 KLRC1 ///

4 /// KLRK1 GNLY KLRC2 FGFBP2 NA NA NA NA NA NA 0,90042493 NA

KLRC4-KLRK1 KLRC1 ///

4 /// KLRK1 KLRD1 KLRC2 FGFBP2 NA NA NA NA NA NA 0,90020773 NA

KLRC4-KLRK1 KLRC1 ///

4 /// KLRK1 KLRC2 EOM ES KLRC4 NA NA NA NA NA NA 0,89981954 NA

4 CD8A EOM ES KLRC3 KLRC4 NA NA NA NA NA NA 0,89942107 NA

KLRC4-KLRK1 KLRC1 ///

5 /// KLRK1 GNLY KLRC2 KLRC4 FGFBP2 NA NA NA NA NA 0,8993804 NA

KLRC4-KLRK1 KLRC1 ///

4 /// KLRK1 GNLY KLRC2 KLRC4 NA NA NA NA NA NA 0,89936507 NA

KLRC4-KLRK1

3 /// KLRK1 KLRD1 KLRC4 NA NA NA NA NA NA NA 0,89931242 NA

KLRC1 ///

5 GNLY KLRC2 EOM ES KLRC3 FGFBP2 NA NA NA NA NA 0,89888859 NA

3 CD8A KLRD1 KLRC4 NA NA NA NA NA NA NA 0,89769889 NA

KLRC4-KLRK1

5 /// KLRK1 CD8A KLRD1 EOM ES KLRC4 NA NA NA NA NA 0,89754497 NA

KLRC4-KLRK1

5 /// KLRK1 KLRD1 GNLY EOM ES FGFBP2 NA NA NA NA NA 0,89740939 NA

KLRC1 ///

5 KLRD1 KLRC2 EOM ES KLRC3 FGFBP2 NA NA NA NA NA 0,89715595 NA

5 CD8A EOM ES KLRC3 KLRC4 FGFBP2 NA NA NA NA NA 0,89698238 NA

KLRC1 ///

4 CD8A KLRC2 KLRC4 FGFBP2 NA NA NA NA NA NA 0,89691548 NA

KLRC4-KLRK1

3 /// KLRK1 CD8A KLRC4 NA NA NA NA NA NA NA 0,89677633 NA

4 CD8A KLRD1 GNLY KLRC4 NA NA NA NA NA NA 0,8965286 NA

KLRC4-KLRK1

5 /// KLRK1 GNLY EOM ES KLRC4 FGFBP2 NA NA NA NA NA 0,89639457 NA

KLRC4-KLRK1 KLRC1 ///

5 /// KLRK1 CD8A KLRC2 KLRC3 KLRC4 NA NA NA NA NA 0,89629487 NA

KLRC1 ///

4 KLRD1 GNLY KLRC2 KLRC4 NA NA NA NA NA NA 0,89622397 NA

KLRC1 ///

6 GNLY KLRC2 EOM ES KLRC3 KLRC4 FGFBP2 NA NA NA NA 0,89593797 NA

KLRC1 ///

5 KLRD1 GNLY KLRC2 KLRC4 FGFBP2 NA NA NA NA NA 0,89586422 NA

KLRC4-KLRK1 KLRC1 ///

4 /// KLRK1 KLRD1 KLRC2 KLRC4 NA NA NA NA NA NA 0,89581538 NA

KLRC4-KLRK1

4 /// KLRK1 GNLY EOM ES KLRC4 NA NA NA NA NA NA 0,89464797 NA

KLRC1 ///

4 GNLY KLRC2 EOM ES KLRC3 NA NA NA NA NA NA 0,89457688 NA

KLRC4-KLRK1 KLRC1 ///

5 /// KLRK1 KLRD1 KLRC2 KLRC4 FGFBP2 NA NA NA NA NA 0,89443536 NA

KLRC4-KLRK1

4 /// KLRK1 CD8A KLRD1 GNLY NA NA NA NA NA NA 0,89424631 NA

KLRC1 ///

3 CD8A KLRC2 FGFBP2 NA NA NA NA NA NA NA 0,89420021 NA

3 CD8A KLRC3 KLRC4 NA NA NA NA NA NA NA 0,89383204 NA

KLRC1 ///

4 KLRD1 KLRC2 EOM ES KLRC3 NA NA NA NA NA NA 0,89348471 NA

5 CD8A KLRD1 GNLY EOM ES KLRC4 NA NA NA NA NA 0,89339293 NA

KLRC4-KLRK1

4 /// KLRK1 GNLY KLRC3 KLRC4 NA NA NA NA NA NA 0,89237057 NA

KLRC4-KLRK1

3 /// KLRK1 GNLY KLRC4 NA NA NA NA NA NA NA 0,89203883 NA

KLRC4-KLRK1

5 /// KLRK1 CD8A KLRD1 GNLY EOM ES NA NA NA NA NA 0,8917059 NA

KLRC1 ///

3 KLRD1 GNLY KLRC2 NA NA NA NA NA NA NA 0,89128993 NA

KLRC1 ///

6 KLRD1 KLRC2 EOM ES KLRC3 KLRC4 FGFBP2 NA NA NA NA 0,8909257 NA

KLRC4-KLRK1

5 /// KLRK1 CD8A GNLY EOM ES FGFBP2 NA NA NA NA NA 0,8907865 NA

4 KLRD1 GNLY KLRC3 KLRC4 NA NA NA NA NA NA 0,88990162 NA

KLRC1 ///

5 GNLY KLRC2 EOM ES KLRC3 KLRC4 NA NA NA NA NA 0,88974259 NA

KLRC1 ///

4 KLRD1 GNLY KLRC2 FGFBP2 NA NA NA NA NA NA 0,88866559 NA

KLRC4-KLRK1

4 /// KLRK1 CD8A GNLY FGFBP2 NA NA NA NA NA NA 0,88793917 NA

4 GNLY EOM ES KLRC3 KLRC4 NA NA NA NA NA NA 0,88767492 NA

4 KLRD1 EOM ES KLRC3 KLRC4 NA NA NA NA NA NA 0,88624942 NA

3 KLRD1 GNLY KLRC3 NA NA NA NA NA NA NA 0,88596417 NA

KLRC4-KLRK1

5 /// KLRK1 KLRD1 EOM ES KLRC4 FGFBP2 NA NA NA NA NA 0,88587145 NA

KLRC4-KLRK1

4 /// KLRK1 KLRD1 GNLY EOM ES NA NA NA NA NA NA 0,88586913 NA

KLRC1 ///

5 KLRD1 KLRC2 EOM ES KLRC3 KLRC4 NA NA NA NA NA 0,8844102 NA

KLRC4-KLRK1

4 /// KLRK1 KLRD1 EOM ES KLRC4 NA NA NA NA NA NA 0,88436118 NA

KLRC4-KLRK1

4 /// KLRK1 CD8A KLRD1 FGFBP2 NA NA NA NA NA NA 0,88396855 NA

3 CD8A EOM ES KLRC3 NA NA NA NA NA NA NA 0,88331021 NA

KLRC4-KLRK1

3 /// KLRK1 CD8A GNLY NA NA NA NA NA NA NA 0,8830672 NA

KLRC4-KLRK1

5 /// KLRK1 CD8A KLRD1 EOM ES FGFBP2 NA NA NA NA NA 0,88220809 NA

KLRC4-KLRK1 KLRC1 ///

5 /// KLRK1 KLRC2 EOM ES KLRC3 FGFBP2 NA NA NA NA NA 0,88118591 NA

5 CD8A GNLY EOM ES KLRC4 FGFBP2 NA NA NA NA NA 0,88076514 NA

KLRC4-KLRK1

3 /// KLRK1 CD8A KLRD1 NA NA NA NA NA NA NA 0,88022434 NA

3 KLRD1 EOM ES KLRC3 NA NA NA NA NA NA NA 0,88009994 NA

4 CD8A EOM ES KLRC3 FGFBP2 NA NA NA NA NA NA 0,87998257 NA

KLRC4-KLRK1

3 /// KLRK1 KLRD1 GNLY NA NA NA NA NA NA NA 0,87986542 NA

5 GNLY EOM ES KLRC3 KLRC4 FGFBP2 NA NA NA NA NA 0,8797811 NA

KLRC4-KLRK1

4 /// KLRK1 GNLY KLRC3 FGFBP2 NA NA NA NA NA NA 0,87972618 NA

KLRC4-KLRK1

4 /// KLRK1 KLRD1 KLRC3 KLRC4 NA NA NA NA NA NA 0,87970193 NA

KLRC4-KLRK1

5 /// KLRK1 CD8A EOM ES KLRC4 FGFBP2 NA NA NA NA NA 0,87952409 NA

KLRC4-KLRK1

5 /// KLRK1 GNLY KLRC3 KLRC4 FGFBP2 NA NA NA NA NA 0,8786334 NA

KLRC4-KLRK1

4 /// KLRK1 CD8A KLRC4 FGFBP2 NA NA NA NA NA NA 0,87850074 NA

5 CD8A KLRD1 EOM ES KLRC4 FGFBP2 NA NA NA NA NA 0,87805021 NA

5 KLRD1 GNLY EOM ES KLRC4 FGFBP2 NA NA NA NA NA 0,87777326 NA

KLRC1 ///

5 KLRD1 GNLY KLRC2 KLRC3 FGFBP2 NA NA NA NA NA 0,87766058 NA

3 CD8A GNLY KLRC4 NA NA NA NA NA NA NA 0,8771677 NA

KLRC4-KLRK1 KLRC1 ///

5 /// KLRK1 GNLY KLRC2 KLRC3 FGFBP2 NA NA NA NA NA 0,87628243 NA

4 CD8A KLRD1 KLRC4 FGFBP2 NA NA NA NA NA NA 0,87624262 NA

3 GNLY EOM ES KLRC3 NA NA NA NA NA NA NA 0,8758787 NA

5 KLRD1 GNLY KLRC3 KLRC4 FGFBP2 NA NA NA NA NA 0,87482668 NA

KLRC4-KLRK1

4 /// KLRK1 KLRD1 GNLY FGFBP2 NA NA NA NA NA NA 0,87472844 NA

KLRC4-KLRK1

4 /// KLRK1 CD8A GNLY EOM ES NA NA NA NA NA NA 0,87460188 NA

KLRC1 ///

6 KLRD1 GNLY KLRC2 KLRC3 KLRC4 FGFBP2 NA NA NA NA 0,87427265 NA

KLRC4-KLRK1 KLRC1 ///

4 /// KLRK1 KLRC2 EOM ES KLRC3 NA NA NA NA NA NA 0,87425641 NA

5 KLRD1 EOM ES KLRC3 KLRC4 FGFBP2 NA NA NA NA NA 0,87369788 NA

KLRC1 ///

4 KLRD1 GNLY KLRC2 KLRC3 NA NA NA NA NA NA 0,87335799 NA

4 KLRD1 GNLY EOM ES KLRC4 NA NA NA NA NA NA 0,87334095 NA

5 CD8A KLRD1 GNLY EOM ES FGFBP2 NA NA NA NA NA 0,87327714 NA

KLRC4-KLRK1 KLRC1 ///

6 /// KLRK1 KLRC2 EOM ES KLRC3 KLRC4 FGFBP2 NA NA NA NA 0,87267461 NA

KLRC4-KLRK1

2 /// KLRK1 KLRD1 NA NA NA NA NA NA NA NA 0,87211632 NA

KLRC4-KLRK1 KLRC1 ///

4 /// KLRK1 GNLY KLRC2 KLRC3 NA NA NA NA NA NA 0,87111511 NA

KLRC1 ///

3 CD8A KLRC2 KLRC3 NA NA NA NA NA NA NA 0,86951507 NA

4 CD8A GNLY EOM ES KLRC4 NA NA NA NA NA NA 0,86923702 NA

KLRC4-KLRK1 KLRC1 ///

6 /// KLRK1 GNLY KLRC2 KLRC3 KLRC4 FGFBP2 NA NA NA NA 0,86895689 NA

KLRC1 ///

4 CD8A KLRC2 KLRC3 FGFBP2 NA NA NA NA NA NA 0,86889304 NA

KLRC4-KLRK1

4 /// KLRK1 KLRD1 KLRC3 FGFBP2 NA NA NA NA NA NA 0,8685964 NA

4 CD8A GNLY KLRC4 FGFBP2 NA NA NA NA NA NA 0,86829337 NA

KLRC1 ///

5 KLRD1 GNLY KLRC2 KLRC3 KLRC4 NA NA NA NA NA 0,86779001 NA

KLRC4-KLRK1

4 /// KLRK1 CD8A EOM ES KLRC4 NA NA NA NA NA NA 0,86705829 NA

4 CD8A KLRD1 EOM ES KLRC4 NA NA NA NA NA NA 0,86597385 NA

KLRC4-KLRK1 KLRC1 ///

5 /// KLRK1 KLRD1 KLRC2 KLRC3 FGFBP2 NA NA NA NA NA 0,86539343 NA

4 GNLY EOM ES KLRC3 FGFBP2 NA NA NA NA NA NA 0,86520875 NA

4 KLRD1 GNLY KLRC3 FGFBP2 NA NA NA NA NA NA 0,86453396 NA

KLRC4-KLRK1

4 /// KLRK1 CD8A KLRD1 EOM ES NA NA NA NA NA NA 0,86362922 NA

KLRC4-KLRK1

4 /// KLRK1 GNLY EOM ES FGFBP2 NA NA NA NA NA NA 0,86351775 NA

KLRC4-KLRK1 KLRC1 ///

5 /// KLRK1 KLRC2 EOM ES KLRC3 KLRC4 NA NA NA NA NA 0,86317904 NA

KLRC4-KLRK1

5 /// KLRK1 KLRD1 KLRC3 KLRC4 FGFBP2 NA NA NA NA NA 0,86262794 NA

KLRC4-KLRK1

3 /// KLRK1 EOM ES KLRC3 NA NA NA NA NA NA NA 0,86248735 NA

2 CD8A KLRC4 NA NA NA NA NA NA NA NA 0,8616116 NA

4 KLRD1 EOM ES KLRC3 FGFBP2 NA NA NA NA NA NA 0,86145768 NA

KLRC4-KLRK1 KLRC1 ///

5 /// KLRK1 GNLY KLRC2 KLRC3 KLRC4 NA NA NA NA NA 0,86129908 NA

KLRC1 ///

5 CD8A KLRC2 KLRC3 KLRC4 FGFBP2 NA NA NA NA NA 0,86126219 NA

Figure imgf000090_0001

Figure imgf000091_0001

Figure imgf000092_0001

Figure imgf000093_0001

Figure imgf000094_0001

Figure imgf000095_0001

Figure imgf000096_0001

Combination of genes for identification of endothelial cells

1 FGFBP2 NA NA NA NA NA NA NA NA NA 0,23362783 NA

9 CDH5 MYCT1 CLEC14A ROB04 EMCN VWF MMRN2 ESAM KDR NA 0,95845253 NA

8 CDH5 MYCT1 CLEC14A ROB04 EMCN VWF ESAM KDR NA NA 0,95800555 NA

7 CDH5 MYCT1 CLEC14A EMCN VWF ESAM KDR NA NA NA 0,95784257 NA

8 MYCT1 CLEC14A OB04 EMCN VWF MMRN2 ESAM KDR NA NA 0,95783516 NA

8 CDH5 MYCT1 CLEC14A EMCN VWF MMRN2 ESAM KDR NA NA 0,9575579 NA

6 CDH5 MYCT1 CLEC14A EMCN VWF ESAM NA NA NA NA 0,95754319 NA

8 CDH5 MYCT1 CLEC14A ROB04 EMCN VWF MMRN2 ESAM NA NA 0,95752418 NA

7 CDH5 MYCT1 CLEC14A EMCN VWF MMRN2 ESAM NA NA NA 0,95700372 NA

7 MYCT1 CLEC14A ROB04 EMCN VWF ESAM KDR NA NA NA 0,95691538 NA

7 CDH5 MYCT1 CLEC14A ROB04 EMCN VWF ESAM NA NA NA 0,95686558 NA

8 CDH5 MYCT1 CLEC14A ROB04 EMCN VWF MMRN2 KDR NA NA 0,95683616 NA

7 CDH5 MYCT1 CLEC14A ROB04 EMCN MMRN2 ESAM NA NA NA 0,95647575 NA

7 MYCT1 CLEC14A ROB04 EMCN VWF MMRN2 ESAM NA NA NA 0,95632336 NA

7 MYCT1 CLEC14A EMCN VWF MMRN2 ESAM KDR NA NA NA 0,95629537 NA

6 MYCT1 CLEC14A EMCN VWF ESAM KDR NA NA NA NA 0,95616531 NA

7 CDH5 MYCT1 CLEC14A ROB04 EMCN VWF KDR NA NA NA 0,9561248 NA

8 CDH5 MYCT1 CLEC14A ROB04 EMCN MMRN2 ESAM KDR NA NA 0,95551279 NA

7 MYCT1 CLEC14A ROB04 EMCN VWF MMRN2 KDR NA NA NA 0,95543829 NA

6 CDH5 MYCT1 CLEC14A EMCN VWF KDR NA NA NA NA 0,95528518 NA

7 CDH5 MYCT1 CLEC14A EMCN VWF MMRN2 KDR NA NA NA 0,955271 NA

6 MYCT1 CLEC14A EMCN VWF MMRN2 ESAM NA NA NA NA 0,95503027 NA

7 CDH5 MYCT1 CLEC14A ROB04 EMCN VWF MMRN2 NA NA NA 0,95500482 NA

8 CDH5 MYCT1 ROB04 EMCN VWF MMRN2 ESAM KDR NA NA 0,95496222 NA

6 MYCT1 CLEC14A ROB04 EMCN MMRN2 ESAM NA NA NA NA 0,95495155 NA

5 MYCT1 CLEC14A EMCN VWF ESAM NA NA NA NA NA 0,9549135 NA

6 MYCT1 CLEC14A ROB04 EMCN VWF ESAM NA NA NA NA 0,95483027 NA

10 CDH5 MYCT1 CLEC14A ROB04 EMCN ELTD1 VWF MMRN2 ESAM KDR 0,95480261 NA

6 CDH5 MYCT1 CLEC14A ROB04 EMCN ESAM NA NA NA NA 0,95475525 NA

9 MYCT1 CLEC14A ROB04 EMCN ELTD1 VWF MMRN2 ESAM KDR NA 0,95410255 NA

7 MYCT1 CLEC14A ROB04 EMCN MMRN2 ESAM KDR NA NA NA 0,95395613 NA

7 CDH5 MYCT1 ROB04 EMCN VWF MMRN2 ESAM NA NA NA 0,95391269 NA

7 CDH5 MYCT1 R0B04 EMCN VWF ESAM KDR NA NA NA 0,95391191 NA

6 MYCT1 CLEC14A R0B04 EMCN VWF KDR NA NA NA NA 0,95390138 NA

9 CDH5 MYCT1 CLEC14A EMCN ELTD1 VWF MMRN2 ESAM KDR NA 0,95386259 NA

6 CDH5 MYCT1 CLEC14A R0B04 EMCN VWF NA NA NA NA 0,95376966 NA

7 CDH5 MYCT1 CLEC14A R0B04 EMCN ESAM KDR NA NA NA 0,95370792 NA

7 MYCT1 0B04 EMCN VWF MMRN2 ESAM KDR NA NA NA 0,95368727 NA

6 CDH5 MYCT1 CLEC14A EMCN VWF MMRN2 NA NA NA NA 0,95351568 NA

9 CDH5 MYCT1 CLEC14A R0B04 EMCN ELTD1 VWF MMRN2 ESAM NA 0,9534452 NA

5 CDH5 MYCT1 CLEC14A EMCN VWF NA NA NA NA NA 0,95344091 NA

6 CDH5 MYCT1 CLEC14A EMCN MMRN2 ESAM NA NA NA NA 0,95334655 NA

7 CDH5 MYCT1 EMCN VWF MMRN2 ESAM KDR NA NA NA 0,95324277 NA

9 CDH5 MYCT1 CLEC14A R0B04 EMCN ELTD1 VWF ESAM KDR NA 0,9529976 NA

6 CDH5 MYCT1 EMCN VWF ESAM KDR NA NA NA NA 0,95280465 NA

7 CDH5 MYCT1 CLEC14A R0B04 EMCN MMRN2 KDR NA NA NA 0,9527461 NA

8 MYCT1 CLEC14A EMCN ELTD1 VWF MMRN2 ESAM KDR NA NA 0,95273556 NA

6 CDH5 MYCT1 CLEC14A R0B04 EMCN MMRN2 NA NA NA NA 0,95273527 NA

6 MYCT1 CLEC14A EMCN VWF MMRN2 KDR NA NA NA NA 0,95268357 NA

8 CDH5 MYCT1 CLEC14A EMCN ELTD1 VWF MMRN2 ESAM NA NA 0,95268343 NA

6 CDH5 MYCT1 R0B04 EMCN VWF ESAM NA NA NA NA 0,95256609 NA

6 CDH5 MYCT1 EMCN VWF MMRN2 ESAM NA NA NA NA 0,95253046 NA

7 CDH5 MYCT1 R0B04 EMCN VWF MMRN2 KDR NA NA NA 0,95240229 NA

6 MYCT1 CLEC14A R0B04 EMCN VWF MMRN2 NA NA NA NA 0,95236093 NA

5 CDH5 MYCT1 EMCN VWF ESAM NA NA NA NA NA 0,95234614 NA

8 CDH5 CLEC14A R0B04 EMCN VWF MMRN2 ESAM KDR NA NA 0,95231961 NA

8 CDH5 MYCT1 CLEC14A EMCN ELTD1 VWF ESAM KDR NA NA 0,95228094 NA

8 MYCT1 CLEC14A R0B04 EMCN ELTD1 VWF MMRN2 ESAM NA NA 0,95225264 NA

9 CDH5 MYCT1 CLEC14A R0B04 EMCN ELTD1 VWF MMRN2 KDR NA 0,95210181 NA

5 CDH5 MYCT1 CLEC14A EMCN ESAM NA NA NA NA NA 0,95208494 NA

7 CDH5 MYCT1 CLEC14A EMCN MMRN2 ESAM KDR NA NA NA 0,95197494 NA

6 MYCT1 0B04 EMCN VWF MMRN2 ESAM NA NA NA NA 0,95192702 NA

6 MYCT1 R0B04 EMCN VWF ESAM KDR NA NA NA NA 0,95183685 NA

5 MYCT1 CLEC14A EMCN VWF KDR NA NA NA NA NA 0,95172462 NA

8 MYCT1 CLEC14A R0B04 EMCN ELTD1 VWF ESAM KDR NA NA 0,95160252 NA

5 MYCT1 CLEC14A R0B04 EMCN ESAM NA NA NA NA NA 0,95146531 NA

6 CDH5 MYCT1 R0B04 EMCN MMRN2 ESAM NA NA NA NA 0,95127385 NA

9 CDH5 MYCT1 CLEC14A R0B04 EMCN ELTD1 MMRN2 ESAM KDR NA 0,95123484 NA

8 CDH5 MYCT1 CLEC14A R0B04 VWF MMRN2 ESAM KDR NA NA 0,9511948 NA

8 CDH5 MYCT1 CLEC14A R0B04 EMCN ELTD1 VWF ESAM NA NA 0,95107194 NA

7 CDH5 CLEC14A R0B04 EMCN VWF ESAM KDR NA NA NA 0,95104637 NA

7 MYCT1 CLEC14A EMCN ELTD1 VWF MMRN2 ESAM NA NA NA 0,95098809 NA

6 MYCT1 EMCN VWF MMRN2 ESAM KDR NA NA NA NA 0,95088459 NA

8 CDH5 MYCT1 CLEC14A R0B04 EMCN ELTD1 MMRN2 ESAM NA NA 0,95082226 NA

6 MYCT1 CLEC14A R0B04 EMCN ESAM KDR NA NA NA NA 0,95078198 NA

6 CDH5 MYCT1 R0B04 EMCN VWF KDR NA NA NA NA 0,95077017 NA

7 CDH5 CLEC14A EMCN VWF MMRN2 ESAM KDR NA NA NA 0,95074895 NA

7 CDH5 MYCT1 CLEC14A EMCN ELTD1 VWF ESAM NA NA NA 0,95064184 NA

9 CDH5 CLEC14A R0B04 EMCN ELTD1 VWF MMRN2 ESAM KDR NA 0,95062874 NA

9 CDH5 MYCT1 R0B04 EMCN ELTD1 VWF MMRN2 ESAM KDR NA 0,95060483 NA

8 MYCT1 CLEC14A R0B04 EMCN ELTD1 VWF MMRN2 KDR NA NA 0,95050868 NA

7 CDH5 CLEC14A R0B04 EMCN VWF MMRN2 KDR NA NA NA 0,95045217 NA

8 CDH5 MYCT1 CLEC14A EMCN ELTD1 VWF MMRN2 KDR NA NA 0,95042186 NA

7 MYCT1 CLEC14A EMCN ELTD1 VWF ESAM KDR NA NA NA 0,9503705 NA

7 CDH5 MYCT1 R0B04 EMCN MMRN2 ESAM KDR NA NA NA 0,95035744 NA

6 CDH5 CLEC14A EMCN VWF ESAM KDR NA NA NA NA 0,9502555 NA

7 CDH5 CLEC14A R0B04 EMCN MMRN2 ESAM KDR NA NA NA 0,95017625 NA

7 CDH5 MYCT1 CLEC14A R0B04 VWF MMRN2 KDR NA NA NA 0,9501157 NA

6 CDH5 MYCT1 R0B04 EMCN VWF MMRN2 NA NA NA NA 0,9501067 NA

6 CDH5 CLEC14A R0B04 EMCN MMRN2 ESAM NA NA NA NA 0,95007926 NA

6 CDH5 MYCT1 CLEC14A EMCN ESAM KDR NA NA NA NA 0,9500687 NA

6 CDH5 MYCT1 CLEC14A R0B04 EMCN KDR NA NA NA NA 0,95006706 NA

7 MYCT1 CLEC14A R0B04 VWF MMRN2 ESAM KDR NA NA NA 0,95001376 NA

9 CDH5 MYCT1 CLEC14A R0B04 ELTD1 VWF MMRN2 ESAM KDR NA 0,94997195 NA

7 CDH5 MYCT1 CLEC14A R0B04 VWF ESAM KDR NA NA NA 0,94992421 NA

6 MYCT1 0B04 EMCN VWF MMRN2 KDR NA NA NA NA 0,94986953 NA

7 CLEC14A R0B04 EMCN VWF MMRN2 ESAM KDR NA NA NA 0,94985459 NA

7 CDH5 MYCT1 CLEC14A VWF MMRN2 ESAM KDR NA NA NA 0,94976502 NA

8 CDH5 MYCT1 CLEC14A R0B04 EMCN ELTD1 VWF MMRN2 NA NA 0,94973531 NA

8 MYCT1 CLEC14A R0B04 EMCN ELTD1 MMRN2 ESAM KDR NA NA 0,94963952 NA

5 CDH5 MYCT1 CLEC14A R0B04 EMCN NA NA NA NA NA 0,94963275 NA

8 CDH5 MYCT1 CLEC14A R0B04 EMCN ELTD1 VWF KDR NA NA 0,94962595 NA

6 MYCT1 CLEC14A R0B04 EMCN MMRN2 KDR NA NA NA NA 0,94961937 NA

7 CDH5 CLEC14A R0B04 EMCN VWF MMRN2 ESAM NA NA NA 0,94958891 NA

6 CDH5 MYCT1 EMCN VWF MMRN2 KDR NA NA NA NA 0,94958119 NA

6 CDH5 MYCT1 CLEC14A VWF ESAM KDR NA NA NA NA 0,94955273 NA

5 MYCT1 EMCN VWF ESAM KDR NA NA NA NA NA 0,94952574 NA

8 CDH5 CLEC14A EMCN ELTD1 VWF MMRN2 ESAM KDR NA NA 0,94948784 NA

5 MYCT1 CLEC14A R0B04 EMCN VWF NA NA NA NA NA 0,94947062 NA

8 MYCT1 CLEC14A R0B04 ELTD1 VWF MMRN2 ESAM KDR NA NA 0,94940878 NA

5 MYCT1 R0B04 EMCN VWF ESAM NA NA NA NA NA 0,94926077 NA

5 MYCT1 CLEC14A EMCN MMRN2 ESAM NA NA NA NA NA 0,94923424 NA

5 MYCT1 EMCN VWF MMRN2 ESAM NA NA NA NA NA 0,94920562 NA

8 MYCT1 R0B04 EMCN ELTD1 VWF MMRN2 ESAM KDR NA NA 0,94911799 NA

5 MYCT1 CLEC14A EMCN VWF MMRN2 NA NA NA NA NA 0,94908914 NA

8 CDH5 MYCT1 CLEC14A ELTD1 VWF MMRN2 ESAM KDR NA NA 0,94903521 NA

8 CLEC14A R0B04 EMCN ELTD1 VWF MMRN2 ESAM KDR NA NA 0,94901943 NA

7 MYCT1 CLEC14A R0B04 EMCN ELTD1 MMRN2 ESAM NA NA NA 0,94891904 NA

6 CDH5 CLEC14A R0B04 EMCN VWF KDR NA NA NA NA 0,9488437 NA

6 CDH5 MYCT1 CLEC14A ROB04 VWF KDR NA NA NA NA 0,94883447 NA

8 CDH5 MYCT1 EMCN ELTD1 VWF MMRN2 ESAM KDR NA NA 0,94883288 NA

8 CDH5 MYCT1 ROB04 EMCN ELTD1 VWF MMRN2 ESAM NA NA 0,94881796 NA

7 MYCT1 CLEC14A ROB04 EMCN ELTD1 VWF ESAM NA NA NA 0,94879526 NA

5 MYCT1 CLEC14A ROB04 EMCN MMRN2 NA NA NA NA NA 0,948658 NA

6 MYCT1 CLEC14A ROB04 VWF MMRN2 KDR NA NA NA NA 0,94843787 NA

5 CDH5 MYCT1 EMCN VWF KDR NA NA NA NA NA 0,94837585 NA

7 CDH5 MYCT1 CLEC14A ROB04 MMRN2 ESAM KDR NA NA NA 0,94832 NA

5 CDH5 MYCT1 CLEC14A VWF KDR NA NA NA NA NA 0,94828991 NA

8 CDH5 CLEC14A ROB04 EMCN ELTD1 VWF ESAM KDR NA NA 0,94826962 NA

8 CDH5 MYCT1 CLEC14A EMCN ELTD1 MMRN2 ESAM KDR NA NA 0,94826436 NA

8 CDH5 CLEC14A ROB04 EMCN ELTD1 VWF MMRN2 ESAM NA NA 0,94825447 NA

6 MYCT1 CLEC14A EMCN MMRN2 ESAM KDR NA NA NA NA 0,94825248 NA

7 MYCT1 CLEC14A ELTD1 VWF MMRN2 ESAM KDR NA NA NA 0,94823728 NA

6 CDH5 MYCT1 CLEC14A VWF MMRN2 KDR NA NA NA NA 0,94817364 NA

5 MYCT1 OB04 EMCN MMRN2 ESAM NA NA NA NA NA 0,94814563 NA

6 CDH5 CLEC14A EMCN VWF MMRN2 KDR NA NA NA NA 0,94807556 NA

6 MYCT1 CLEC14A ROB04 VWF ESAM KDR NA NA NA NA 0,94806073 NA

6 CDH5 CLEC14A EMCN VWF MMRN2 ESAM NA NA NA NA 0,94805378 NA

7 CDH5 ROB04 EMCN VWF MMRN2 ESAM KDR NA NA NA 0,94803833 NA

5 CDH5 MYCT1 ROB04 EMCN ESAM NA NA NA NA NA 0,94799564 NA

7 CDH5 MYCT1 CLEC14A EMCN ELTD1 VWF KDR NA NA NA 0,94799011 NA

7 MYCT1 CLEC14A EMCN ELTD1 VWF MMRN2 KDR NA NA NA 0,94797913 NA

7 CDH5 MYCT1 CLEC14A ROB04 VWF MMRN2 ESAM NA NA NA 0,94796442 NA

8 CDH5 MYCT1 ROB04 EMCN ELTD1 VWF ESAM KDR NA NA 0,9479478 NA

7 CDH5 MYCT1 CLEC14A EMCN ELTD1 MMRN2 ESAM NA NA NA 0,94793438 NA

7 CDH5 MYCT1 CLEC14A EMCN ELTD1 VWF MMRN2 NA NA NA 0,9479319 NA

8 CDH5 MYCT1 CLEC14A ROB04 EMCN ELTD1 ESAM KDR NA NA 0,94791939 NA

6 MYCT1 CLEC14A VWF MMRN2 ESAM KDR NA NA NA NA 0,94781719 NA

8 CDH5 CLEC14A ROB04 EMCN ELTD1 MMRN2 ESAM KDR NA NA 0,9477904 NA

6 CDH5 MYCT1 CLEC14A ROB04 MMRN2 ESAM NA NA NA NA 0,94778431 NA

6 MYCT1 CLEC14A EMCN ELTD1 VWF ESAM NA NA NA NA 0,94772241 NA

8 CDH5 CLEC14A ROB04 EMCN ELTD1 VWF MMRN2 KDR NA NA 0,94772185 NA

4 MYCT1 EMCN VWF ESAM NA NA NA NA NA NA 0,94766941 NA

5 CDH5 MYCT1 ROB04 EMCN VWF NA NA NA NA NA 0,94765919 NA

6 CDH5 CLEC14A ROB04 EMCN ESAM KDR NA NA NA NA 0,94759027 NA

8 CDH5 MYCT1 CLEC14A ROB04 ELTD1 VWF ESAM KDR NA NA 0,94757787 NA

8 CDH5 MYCT1 CLEC14A ROB04 ELTD1 VWF MMRN2 KDR NA NA 0,94755517 NA

6 CDH5 CLEC14A ROB04 EMCN VWF ESAM NA NA NA NA 0,94751924 NA

6 CDH5 MYCT1 CLEC14A EMCN MMRN2 KDR NA NA NA NA 0,94747353 NA

6 CLEC14A OB04 EMCN VWF ESAM KDR NA NA NA NA 0,94741722 NA

7 CDH5 CLEC14A EMCN ELTD1 VWF ESAM KDR NA NA NA 0,94740687 NA

6 CDH5 CLEC14A ROB04 EMCN MMRN2 KDR NA NA NA NA 0,94736678 NA

6 MYCT1 ROB04 EMCN MMRN2 ESAM KDR NA NA NA NA 0,94734794 NA

8 CDH5 MYCT1 CLEC14A ROB04 ELTD1 VWF MMRN2 ESAM NA NA 0,94734621 NA

5 CDH5 CLEC14A ROB04 EMCN ESAM NA NA NA NA NA 0,94730652 NA

5 CDH5 CLEC14A EMCN VWF KDR NA NA NA NA NA 0,94728042 NA

5 MYCT1 CLEC14A VWF ESAM KDR NA NA NA NA NA 0,94727197 NA

7 CLEC14A EMCN ELTD1 VWF MMRN2 ESAM KDR NA NA NA 0,94726031 NA

8 CDH5 MYCT1 CLEC14A ROB04 EMCN ELTD1 MMRN2 KDR NA NA 0,94723648 NA

7 CDH5 CLEC14A EMCN ELTD1 VWF MMRN2 ESAM NA NA NA 0,94721796 NA

5 CDH5 CLEC14A EMCN VWF ESAM NA NA NA NA NA 0,94721365 NA

6 CDH5 MYCT1 ROB04 EMCN ESAM KDR NA NA NA NA 0,94718768 NA

5 CDH5 MYCT1 CLEC14A EMCN MMRN2 NA NA NA NA NA 0,94716372 NA

7 MYCT1 CLEC14A ROB04 EMCN ELTD1 VWF MMRN2 NA NA NA 0,94710882 NA

5 CDH5 MYCT1 EMCN VWF MMRN2 NA NA NA NA NA 0,94709624 NA

7 CDH5 MYCT1 EMCN ELTD1 VWF MMRN2 ESAM NA NA NA 0,9470815 NA

7 CDH5 MYCT1 CLEC14A ELTD1 VWF ESAM KDR NA NA NA 0,94706952 NA

4 MYCT1 CLEC14A EMCN VWF NA NA NA NA NA NA 0,94699689 NA

6 CLEC14A EMCN VWF MMRN2 ESAM KDR NA NA NA NA 0,94699278 NA

7 MYCT1 CLEC14A ROB04 EMCN ELTD1 VWF KDR NA NA NA 0,946912 NA

7 CDH5 MYCT1 ROB04 VWF MMRN2 ESAM KDR NA NA NA 0,94688992 NA

8 CDH5 MYCT1 ROB04 EMCN ELTD1 VWF MMRN2 KDR NA NA 0,94688504 NA

7 CDH5 CLEC14A ROB04 EMCN ELTD1 MMRN2 ESAM NA NA NA 0,94684423 NA

6 CLEC14A OB04 EMCN VWF MMRN2 KDR NA NA NA NA 0,94680083 NA

7 CDH5 MYCT1 CLEC14A ROB04 EMCN ELTD1 ESAM NA NA NA 0,94679558 NA

5 MYCT1 ROB04 EMCN VWF KDR NA NA NA NA NA 0,94677222 NA

6 CLEC14A ROB04 EMCN MMRN2 ESAM KDR NA NA NA NA 0,94674454 NA

8 CDH5 MYCT1 CLEC14A ROB04 ELTD1 MMRN2 ESAM KDR NA NA 0,94664295 NA

6 CDH5 MYCT1 CLEC14A VWF MMRN2 ESAM NA NA NA NA 0,94662256 NA

7 MYCT1 ROB04 EMCN ELTD1 VWF MMRN2 ESAM NA NA NA 0,94661046 NA

7 CDH5 MYCT1 CLEC14A ELTD1 VWF MMRN2 ESAM NA NA NA 0,94660035 NA

7 MYCT1 EMCN ELTD1 VWF MMRN2 ESAM KDR NA NA NA 0,94656173 NA

6 MYCT1 CLEC14A ROB04 MMRN2 ESAM KDR NA NA NA NA 0,94654882 NA

6 CDH5 MYCT1 CLEC14A ROB04 MMRN2 KDR NA NA NA NA 0,94646686 NA

6 CDH5 CLEC14A ROB04 EMCN VWF MMRN2 NA NA NA NA 0,94637698 NA

5 MYCT1 CLEC14A ROB04 VWF KDR NA NA NA NA NA 0,94630134 NA

7 CDH5 MYCT1 CLEC14A ROB04 EMCN ELTD1 VWF NA NA NA 0,9462891 NA

7 MYCT1 CLEC14A ROB04 ELTD1 VWF MMRN2 KDR NA NA NA 0,94623815 NA

7 MYCT1 CLEC14A ROB04 ELTD1 VWF ESAM KDR NA NA NA 0,94623738 NA

7 CDH5 MYCT1 EMCN ELTD1 VWF ESAM KDR NA NA NA 0,94617713 NA

5 CDH5 MYCT1 CLEC14A VWF ESAM NA NA NA NA NA 0,94614155 NA

5 MYCT1 CLEC14A ROB04 MMRN2 ESAM NA NA NA NA NA 0,94609267 NA

5 CDH5 CLEC14A ROB04 EMCN MMRN2 NA NA NA NA NA 0,94608006 NA

7 MYCT1 CLEC14A ROB04 ELTD1 VWF MMRN2 ESAM NA NA NA 0,94604726 NA

7 CDH5 MYCT1 CLEC14A ELTD1 VWF MMRN2 KDR NA NA NA 0,94594875 NA

5 CDH5 MYCT1 EMCN MMRN2 ESAM NA NA NA NA NA 0,94594515 NA

6 CDH5 MYCT1 ROB04 EMCN MMRN2 KDR NA NA NA NA 0,94591999 NA

5 CDH5 CLEC14A EMCN MMRN2 ESAM NA NA NA NA NA 0,94590987 NA

6 CDH5 OB04 EMCN VWF ESAM KDR NA NA NA NA 0,94589711 NA

5 MYCT1 ROB04 EMCN VWF MMRN2 NA NA NA NA NA 0,94585176 NA

8 CDH5 ROB04 EMCN ELTD1 VWF MMRN2 ESAM KDR NA NA 0,94581979 NA

5 CLEC14A ROB04 EMCN MMRN2 ESAM NA NA NA NA NA 0,9457815 NA

6 CDH5 MYCT1 CLEC14A ROB04 VWF ESAM NA NA NA NA 0,94576976 NA

7 CDH5 CLEC14A EMCN ELTD1 VWF MMRN2 KDR NA NA NA 0,94576151 NA

6 CDH5 CLEC14A EMCN MMRN2 ESAM KDR NA NA NA NA 0,94569694 NA

6 CDH5 MYCT1 CLEC14A ROB04 VWF MMRN2 NA NA NA NA 0,94566939 NA

7 CLEC14A ROB04 EMCN ELTD1 VWF MMRN2 ESAM NA NA NA 0,94566056 NA

7 CLEC14A ROB04 EMCN ELTD1 VWF ESAM KDR NA NA NA 0,9456182 NA

6 MYCT1 CLEC14A ELTD1 VWF ESAM KDR NA NA NA NA 0,94557929 NA

7 MYCT1 CLEC14A ROB04 ELTD1 MMRN2 ESAM KDR NA NA NA 0,94554499 NA

7 CDH5 MYCT1 CLEC14A ROB04 EMCN ELTD1 MMRN2 NA NA NA 0,94552055 NA

7 CDH5 MYCT1 CLEC14A ROB04 ELTD1 MMRN2 ESAM NA NA NA 0,94548406 NA

4 CDH5 MYCT1 EMCN VWF NA NA NA NA NA NA 0,94545124 NA

6 CDH5 MYCT1 CLEC14A ROB04 ESAM KDR NA NA NA NA 0,94545021 NA

8 CDH5 MYCT1 ROB04 EMCN ELTD1 MMRN2 ESAM KDR NA NA 0,94542755 NA

7 CLEC14A ROB04 EMCN ELTD1 MMRN2 ESAM KDR NA NA NA 0,9454033 NA

7 MYCT1 ROB04 EMCN ELTD1 VWF ESAM KDR NA NA NA 0,94537987 NA

6 CLEC14A ROB04 EMCN VWF MMRN2 ESAM NA NA NA NA 0,94537067 NA

6 CDH5 EMCN VWF MMRN2 ESAM KDR NA NA NA NA 0,94535867 NA

7 CDH5 MYCT1 ROB04 EMCN ELTD1 VWF ESAM NA NA NA 0,94534402 NA

7 MYCT1 CLEC14A EMCN ELTD1 MMRN2 ESAM KDR NA NA NA 0,9453382 NA

6 MYCT1 CLEC14A ROB04 VWF MMRN2 ESAM NA NA NA NA 0,94531792 NA

5 MYCT1 CLEC14A VWF MMRN2 KDR NA NA NA NA NA 0,94526302 NA

5 CDH5 MYCT1 ROB04 EMCN MMRN2 NA NA NA NA NA 0,94524652 NA

5 CLEC14A EMCN VWF ESAM KDR NA NA NA NA NA 0,94515906 NA

5 CDH5 MYCT1 CLEC14A ROB04 MMRN2 NA NA NA NA NA 0,94512439 NA

8 CDH5 MYCT1 ROB04 ELTD1 VWF MMRN2 ESAM KDR NA NA 0,94508785 NA

6 MYCT1 CLEC14A ELTD1 VWF MMRN2 ESAM NA NA NA NA 0,94508112 NA

4 MYCT1 CLEC14A VWF KDR NA NA NA NA NA NA 0,9450565 NA

4 MYCT1 CLEC14A EMCN ESAM NA NA NA NA NA NA 0,94504601 NA

5 MYCT1 EMCN VWF MMRN2 KDR NA NA NA NA NA 0,94502007 NA

6 CDH5 ROB04 EMCN VWF MMRN2 KDR NA NA NA NA 0,94500324 NA

7 CDH5 CLEC14A ROB04 EMCN ELTD1 VWF ESAM NA NA NA 0,94499869 NA

7 CLEC14A ROB04 EMCN ELTD1 VWF MMRN2 KDR NA NA NA 0,94499519 NA

6 CDH5 MYCT1 EMCN MMRN2 ESAM KDR NA NA NA NA 0,94491577 NA

6 MYCT1 ROB04 VWF MMRN2 ESAM KDR NA NA NA NA 0,94488619 NA

6 CDH5 ROB04 EMCN VWF MMRN2 ESAM NA NA NA NA 0,94487205 NA

7 MYCT1 CLEC14A ROB04 EMCN ELTD1 ESAM KDR NA NA NA 0,94486875 NA

6 CDH5 MYCT1 ROB04 VWF ESAM KDR NA NA NA NA 0,94476396 NA

6 CDH5 MYCT1 ROB04 VWF MMRN2 KDR NA NA NA NA 0,94475304 NA

5 CDH5 MYCT1 CLEC14A ROB04 ESAM NA NA NA NA NA 0,94463495 NA

7 CDH5 CLEC14A ROB04 EMCN ELTD1 VWF KDR NA NA NA 0,94457762 NA

7 CDH5 CLEC14A EMCN ELTD1 MMRN2 ESAM KDR NA NA NA 0,94455315 NA

7 CDH5 MYCT1 CLEC14A EMCN ELTD1 ESAM KDR NA NA NA 0,94451429 NA

6 CDH5 MYCT1 CLEC14A EMCN ELTD1 VWF NA NA NA NA 0,94449379 NA

7 CDH5 MYCT1 CLEC14A ROB04 ELTD1 VWF KDR NA NA NA 0,9444928 NA

5 MYCT1 CLEC14A ROB04 EMCN KDR NA NA NA NA NA 0,94448911 NA

6 OB04 EMCN VWF MMRN2 ESAM KDR NA NA NA NA 0,94444423 NA

6 MYCT1 CLEC14A EMCN ELTD1 MMRN2 ESAM NA NA NA NA 0,94443559 NA

7 CDH5 MYCT1 ROB04 EMCN ELTD1 MMRN2 ESAM NA NA NA 0,94439954 NA

6 CDH5 MYCT1 VWF MMRN2 ESAM KDR NA NA NA NA 0,94436227 NA

6 CDH5 CLEC14A EMCN ELTD1 VWF ESAM NA NA NA NA 0,94435425 NA

6 MYCT1 CLEC14A ROB04 ELTD1 MMRN2 ESAM NA NA NA NA 0,94433846 NA

6 MYCT1 CLEC14A EMCN ELTD1 VWF KDR NA NA NA NA 0,94412315 NA

6 MYCT1 CLEC14A EMCN ELTD1 VWF MMRN2 NA NA NA NA 0,94408752 NA

5 CDH5 MYCT1 CLEC14A EMCN KDR NA NA NA NA NA 0,94408504 NA

7 MYCT1 CLEC14A ROB04 EMCN ELTD1 MMRN2 KDR NA NA NA 0,94407754 NA

7 MYCT1 OB04 EMCN ELTD1 VWF MMRN2 KDR NA NA NA 0,94407037 NA

7 CDH5 CLEC14A ROB04 EMCN ELTD1 VWF MMRN2 NA NA NA 0,94406554 NA

6 CDH5 ROB04 EMCN MMRN2 ESAM KDR NA NA NA NA 0,94406317 NA

5 MYCT1 CLEC14A EMCN ESAM KDR NA NA NA NA NA 0,9440444 NA

6 MYCT1 CLEC14A ELTD1 VWF MMRN2 KDR NA NA NA NA 0,94401294 NA

7 CDH5 MYCT1 EMCN ELTD1 VWF MMRN2 KDR NA NA NA 0,94400471 NA

6 CLEC14A EMCN ELTD1 VWF ESAM KDR NA NA NA NA 0,94398762 NA

7 CDH5 MYCT1 CLEC14A ROB04 ELTD1 VWF ESAM NA NA NA 0,94397123 NA

4 CDH5 CLEC14A EMCN ESAM NA NA NA NA NA NA 0,94389966 NA

7 CDH5 CLEC14A ROB04 EMCN ELTD1 ESAM KDR NA NA NA 0,94389461 NA

6 MYCT1 EMCN ELTD1 VWF MMRN2 ESAM NA NA NA NA 0,94387427 NA

6 CLEC14A ROB04 EMCN ELTD1 MMRN2 ESAM NA NA NA NA 0,94386288 NA

5 CDH5 CLEC14A ROB04 EMCN KDR NA NA NA NA NA 0,94385661 NA

6 CDH5 MYCT1 CLEC14A ELTD1 VWF ESAM NA NA NA NA 0,94385244 NA

5 CDH5 EMCN VWF ESAM KDR NA NA NA NA NA 0,94379729 NA

6 CLEC14A EMCN ELTD1 VWF MMRN2 ESAM NA NA NA NA 0,94379507 NA

6 CDH5 CLEC14A EMCN ELTD1 MMRN2 ESAM NA NA NA NA 0,94377567 NA

5 CDH5 ROB04 EMCN MMRN2 ESAM NA NA NA NA NA 0,94376782 NA

7 CDH5 MYCT1 ROB04 EMCN ELTD1 VWF MMRN2 NA NA NA 0,94373482 NA

5 MYCT1 CLEC14A ROB04 MMRN2 KDR NA NA NA NA NA 0,9437334 NA

7 CDH5 MYCT1 CLEC14A ROB04 ELTD1 VWF MMRN2 NA NA NA 0,94369447 NA

7 CDH5 EMCN ELTD1 VWF MMRN2 ESAM KDR NA NA NA 0,94367113 NA

7 CDH5 CLEC14A ROB04 EMCN ELTD1 MMRN2 KDR NA NA NA 0,94363962 NA

6 CDH5 MYCT1 EMCN ELTD1 VWF ESAM NA NA NA NA 0,94363842 NA

7 MYCT1 ROB04 ELTD1 VWF MMRN2 ESAM KDR NA NA NA 0,94361023 NA

8 CDH5 CLEC14A ROB04 ELTD1 VWF MMRN2 ESAM KDR NA NA 0,94360301 NA

6 CDH5 MYCT1 CLEC14A MMRN2 ESAM KDR NA NA NA NA 0,94354541 NA

5 CDH5 CLEC14A EMCN VWF MMRN2 NA NA NA NA NA 0,94353061 NA

4 CDH5 MYCT1 CLEC14A EMCN NA NA NA NA NA NA 0,94351862 NA

5 CDH5 MYCT1 CLEC14A VWF MMRN2 NA NA NA NA NA 0,94345847 NA

6 CDH5 MYCT1 CLEC14A EMCN ELTD1 ESAM NA NA NA NA 0,94345113 NA

5 CDH5 CLEC14A ROB04 EMCN VWF NA NA NA NA NA 0,94340946 NA

5 CLEC14A ROB04 EMCN VWF KDR NA NA NA NA NA 0,94340373 NA

7 CDH5 MYCT1 CLEC14A ELTD1 MMRN2 ESAM KDR NA NA NA 0,94339569 NA

5 CDH5 MYCT1 CLEC14A MMRN2 ESAM NA NA NA NA NA 0,9433847 NA

6 CDH5 MYCT1 ROB04 VWF MMRN2 ESAM NA NA NA NA 0,94322186 NA

6 CDH5 MYCT1 CLEC14A ELTD1 VWF KDR NA NA NA NA 0,94320846 NA

7 CDH5 MYCT1 ROB04 EMCN ELTD1 VWF KDR NA NA NA 0,94320592 NA

5 CDH5 MYCT1 VWF ESAM KDR NA NA NA NA NA 0,94317872 NA

7 OB04 EMCN ELTD1 VWF MMRN2 ESAM KDR NA NA NA 0,94314706 NA

7 CDH5 MYCT1 ELTD1 VWF MMRN2 ESAM KDR NA NA NA 0,94313311 NA

5 CDH5 MYCT1 CLEC14A ROB04 KDR NA NA NA NA NA 0,9430895 NA

4 CDH5 MYCT1 CLEC14A VWF NA NA NA NA NA NA 0,9430482 NA

7 CDH5 MYCT1 CLEC14A ROB04 ELTD1 MMRN2 KDR NA NA NA 0,94301461 NA

5 CDH5 MYCT1 CLEC14A ROB04 VWF NA NA NA NA NA 0,94300589 NA

5 CDH5 CLEC14A EMCN ESAM KDR NA NA NA NA NA 0,94296402 NA

5 MYCT1 CLEC14A VWF MMRN2 ESAM NA NA NA NA NA 0,94283637 NA

7 CDH5 ROB04 EMCN ELTD1 VWF MMRN2 ESAM NA NA NA 0,94281143 NA

6 MYCT1 CLEC14A ROB04 EMCN ELTD1 ESAM NA NA NA NA 0,94280113 NA

7 CDH5 MYCT1 CLEC14A EMCN ELTD1 MMRN2 KDR NA NA NA 0,9427626 NA

6 CDH5 CLEC14A EMCN ELTD1 VWF KDR NA NA NA NA 0,94269565 NA

7 CDH5 MYCT1 CLEC14A ROB04 EMCN ELTD1 KDR NA NA NA 0,94263224 NA

6 MYCT1 EMCN ELTD1 VWF ESAM KDR NA NA NA NA 0,94254749 NA

6 CDH5 MYCT1 CLEC14A ELTD1 MMRN2 ESAM NA NA NA NA 0,94251689 NA

7 CDH5 MYCT1 CLEC14A ROB04 ELTD1 ESAM KDR NA NA NA 0,94249949 NA

7 MYCT1 OB04 EMCN ELTD1 MMRN2 ESAM KDR NA NA NA 0,9423922 NA

7 CDH5 ROB04 EMCN ELTD1 VWF ESAM KDR NA NA NA 0,94238765 NA

5 CLEC14A EMCN VWF MMRN2 KDR NA NA NA NA NA 0,94226245 NA

5 CDH5 MYCT1 ROB04 VWF KDR NA NA NA NA NA 0,9422484 NA

4 CDH5 MYCT1 EMCN ESAM NA NA NA NA NA NA 0,94223056 NA

7 CDH5 CLEC14A ELTD1 VWF MMRN2 ESAM KDR NA NA NA 0,94214747 NA

5 CDH5 ROB04 EMCN VWF KDR NA NA NA NA NA 0,94208286 NA

5 CDH5 EMCN VWF MMRN2 ESAM NA NA NA NA NA 0,94205512 NA

6 CDH5 CLEC14A ROB04 EMCN ELTD1 ESAM NA NA NA NA 0,94199135 NA

5 MYCT1 CLEC14A ROB04 ESAM KDR NA NA NA NA NA 0,94197005 NA

6 CDH5 MYCT1 ROB04 MMRN2 ESAM KDR NA NA NA NA 0,94195499 NA

6 MYCT1 CLEC14A ROB04 ELTD1 VWF KDR NA NA NA NA 0,9419485 NA

6 CDH5 MYCT1 CLEC14A ELTD1 VWF MMRN2 NA NA NA NA 0,94193234 NA

4 MYCT1 CLEC14A ROB04 MMRN2 NA NA NA NA NA NA 0,94187209 NA

6 CLEC14A EMCN ELTD1 VWF MMRN2 KDR NA NA NA NA 0,94186023 NA

5 CLEC14A ROB04 EMCN MMRN2 KDR NA NA NA NA NA 0,941852 NA

5 CLEC14A EMCN VWF MMRN2 ESAM NA NA NA NA NA 0,94183272 NA

5 CLEC14A ROB04 EMCN ESAM KDR NA NA NA NA NA 0,94181245 NA

6 CDH5 CLEC14A EMCN ELTD1 VWF MMRN2 NA NA NA NA 0,94180871 NA

7 CDH5 MYCT1 ROB04 ELTD1 VWF MMRN2 ESAM NA NA NA 0,94180189 NA

6 MYCT1 CLEC14A ROB04 EMCN ELTD1 VWF NA NA NA NA 0,94178607 NA

5 MYCT1 ROB04 EMCN ESAM KDR NA NA NA NA NA 0,94178174 NA

4 CDH5 CLEC14A ROB04 EMCN NA NA NA NA NA NA 0,94174309 NA

4 CDH5 CLEC14A EMCN VWF NA NA NA NA NA NA 0,94172281 NA

5 MYCT1 ROB04 VWF MMRN2 KDR NA NA NA NA NA 0,94171325 NA

4 MYCT1 EMCN VWF KDR NA NA NA NA NA NA 0,94170283 NA

7 CDH5 ROB04 EMCN ELTD1 VWF MMRN2 KDR NA NA NA 0,94170004 NA

5 CDH5 ROB04 EMCN VWF ESAM NA NA NA NA NA 0,94166084 NA

5 MYCT1 ROB04 VWF ESAM KDR NA NA NA NA NA 0,94162035 NA

4 MYCT1 OB04 EMCN ESAM NA NA NA NA NA NA 0,94160552 NA

4 MYCT1 CLEC14A ROB04 EMCN NA NA NA NA NA NA 0,94160303 NA

7 CDH5 MYCT1 ROB04 ELTD1 VWF ESAM KDR NA NA NA 0,94157442 NA

5 MYCT1 CLEC14A ROB04 VWF MMRN2 NA NA NA NA NA 0,94155384 NA

4 CDH5 MYCT1 CLEC14A ESAM NA NA NA NA NA NA 0,94151864 NA

5 MYCT1 CLEC14A ROB04 VWF ESAM NA NA NA NA NA 0,94148451 NA

7 CLEC14A ROB04 ELTD1 VWF MMRN2 ESAM KDR NA NA NA 0,94147739 NA

7 CDH5 MYCT1 ROB04 ELTD1 VWF MMRN2 KDR NA NA NA 0,94147088 NA

6 MYCT1 ROB04 EMCN ELTD1 VWF ESAM NA NA NA NA 0,94145003 NA

4 MYCT1 CLEC14A VWF ESAM NA NA NA NA NA NA 0,94138167 NA

6 MYCT1 CLEC14A ROB04 ELTD1 VWF ESAM NA NA NA NA 0,94127513 NA

5 CDH5 MYCT1 ROB04 MMRN2 ESAM NA NA NA NA NA 0,94126888 NA

7 CDH5 ROB04 EMCN ELTD1 MMRN2 ESAM KDR NA NA NA 0,94121065 NA

4 CDH5 MYCT1 CLEC14A ROB04 NA NA NA NA NA NA 0,94120289 NA

6 MYCT1 CLEC14A ROB04 EMCN ELTD1 MMRN2 NA NA NA NA 0,94118732 NA

5 CDH5 MYCT1 VWF MMRN2 KDR NA NA NA NA NA 0,94116585 NA

6 CDH5 CLEC14A ROB04 EMCN ELTD1 MMRN2 NA NA NA NA 0,94115849 NA

7 CDH5 CLEC14A ROB04 ELTD1 MMRN2 ESAM KDR NA NA NA 0,94112235 NA

5 MYCT1 CLEC14A ELTD1 VWF ESAM NA NA NA NA NA 0,94107899 NA

5 CDH5 MYCT1 ROB04 EMCN KDR NA NA NA NA NA 0,94106672 NA

6 MYCT1 CLEC14A ELTD1 MMRN2 ESAM KDR NA NA NA NA 0,94104603 NA

5 CLEC14A ROB04 EMCN VWF ESAM NA NA NA NA NA 0,94100723 NA

5 MYCT1 VWF MMRN2 ESAM KDR NA NA NA NA NA 0,94098989 NA

6 MYCT1 ELTD1 VWF MMRN2 ESAM KDR NA NA NA NA 0,94098374 NA

6 MYCT1 CLEC14A ROB04 ELTD1 VWF MMRN2 NA NA NA NA 0,94094931 NA

7 CDH5 CLEC14A ROB04 VWF MMRN2 ESAM KDR NA NA NA 0,94094376 NA

5 CDH5 EMCN VWF MMRN2 KDR NA NA NA NA NA 0,94092129 NA

5 CDH5 MYCT1 EMCN ESAM KDR NA NA NA NA NA 0,94090241 NA

7 CDH5 MYCT1 EMCN ELTD1 MMRN2 ESAM KDR NA NA NA 0,94086709 NA

4 MYCT1 CLEC14A ROB04 ESAM NA NA NA NA NA NA 0,94086257 NA

7 CDH5 CLEC14A ROB04 ELTD1 VWF MMRN2 KDR NA NA NA 0,94085966 NA

5 CDH5 CLEC14A EMCN MMRN2 KDR NA NA NA NA NA 0,94081921 NA

5 CDH5 MYCT1 VWF MMRN2 ESAM NA NA NA NA NA 0,94066588 NA

6 CLEC14A ROB04 EMCN ELTD1 VWF ESAM NA NA NA NA 0,94066307 NA

6 MYCT1 ROB04 EMCN ELTD1 MMRN2 ESAM NA NA NA NA 0,94064642 NA

5 CDH5 MYCT1 CLEC14A ESAM KDR NA NA NA NA NA 0,94062656 NA

7 CDH5 MYCT1 ROB04 EMCN ELTD1 ESAM KDR NA NA NA 0,94059495 NA

4 MYCT1 ROB04 EMCN VWF NA NA NA NA NA NA 0,94057483 NA

6 CDH5 EMCN ELTD1 VWF MMRN2 ESAM NA NA NA NA 0,94055378 NA

6 MYCT1 CLEC14A ROB04 ELTD1 MMRN2 KDR NA NA NA NA 0,94054473 NA

5 MYCT1 CLEC14A EMCN MMRN2 KDR NA NA NA NA NA 0,94053921 NA

6 CDH5 MYCT1 CLEC14A EMCN ELTD1 MMRN2 NA NA NA NA 0,94051673 NA

5 OB04 EMCN VWF ESAM KDR NA NA NA NA NA 0,94049841 NA

6 CLEC14A EMCN ELTD1 MMRN2 ESAM KDR NA NA NA NA 0,94049702 NA

6 CDH5 MYCT1 CLEC14A ROB04 ELTD1 MMRN2 NA NA NA NA 0,94042168 NA

6 CDH5 MYCT1 EMCN ELTD1 VWF MMRN2 NA NA NA NA 0,9404009 NA

6 CDH5 MYCT1 CLEC14A ROB04 ELTD1 ESAM NA NA NA NA 0,94026191 NA

6 CDH5 EMCN ELTD1 VWF ESAM KDR NA NA NA NA 0,94022258 NA

5 MYCT1 CLEC14A ELTD1 MMRN2 ESAM NA NA NA NA NA 0,94021993 NA

6 CDH5 CLEC14A EMCN ELTD1 ESAM KDR NA NA NA NA 0,94021856 NA

6 CLEC14A ROB04 EMCN ELTD1 VWF KDR NA NA NA NA 0,94021791 NA

5 MYCT1 ROB04 EMCN MMRN2 KDR NA NA NA NA NA 0,94021633 NA

7 CDH5 CLEC14A ROB04 ELTD1 VWF ESAM KDR NA NA NA 0,94010303 NA

6 CDH5 MYCT1 EMCN ELTD1 VWF KDR NA NA NA NA 0,93997584 NA

5 MYCT1 CLEC14A ELTD1 VWF KDR NA NA NA NA NA 0,9399549 NA

5 CDH5 ROB04 EMCN VWF MMRN2 NA NA NA NA NA 0,93995074 NA

4 CDH5 EMCN VWF ESAM NA NA NA NA NA NA 0,93992067 NA

5 CDH5 MYCT1 ROB04 VWF ESAM NA NA NA NA NA 0,93990625 NA

6 EMCN ELTD1 VWF MMRN2 ESAM KDR NA NA NA NA 0,9398754 NA

5 CDH5 MYCT1 CLEC14A MMRN2 KDR NA NA NA NA NA 0,93986516 NA

6 CDH5 MYCT1 ELTD1 VWF MMRN2 ESAM NA NA NA NA 0,939838 NA

7 CDH5 MYCT1 ROB04 EMCN ELTD1 MMRN2 KDR NA NA NA 0,93980947 NA

7 CDH5 MYCT1 ROB04 ELTD1 MMRN2 ESAM KDR NA NA NA 0,93980926 NA

4 CDH5 MYCT1 VWF KDR NA NA NA NA NA NA 0,93977811 NA

6 CDH5 MYCT1 ELTD1 VWF ESAM KDR NA NA NA NA 0,93975886 NA

6 MYCT1 CLEC14A ROB04 ELTD1 ESAM KDR NA NA NA NA 0,93974923 NA

6 MYCT1 EMCN ELTD1 VWF MMRN2 KDR NA NA NA NA 0,9397199 NA

5 CLEC14A ROB04 EMCN VWF MMRN2 NA NA NA NA NA 0,93971869 NA

5 EMCN VWF MMRN2 ESAM KDR NA NA NA NA NA 0,93970251 NA

4 MYCT1 EMCN VWF MMRN2 NA NA NA NA NA NA 0,9396854 NA

5 CDH5 ROB04 EMCN ESAM KDR NA NA NA NA NA 0,93965662 NA

6 CLEC14A ROB04 EMCN ELTD1 ESAM KDR NA NA NA NA 0,93956401 NA

6 CLEC14A ROB04 EMCN ELTD1 VWF MMRN2 NA NA NA NA 0,93955078 NA

6 CDH5 MYCT1 EMCN ELTD1 MMRN2 ESAM NA NA NA NA 0,9395469 NA

6 CDH5 MYCT1 CLEC14A ROB04 EMCN ELTD1 NA NA NA NA 0,93950292 NA

6 MYCT1 CLEC14A EMCN ELTD1 ESAM KDR NA NA NA NA 0,93948959 NA

5 OB04 EMCN VWF MMRN2 KDR NA NA NA NA NA 0,93948537 NA

6 CDH5 ROB04 EMCN ELTD1 MMRN2 ESAM NA NA NA NA 0,93946183 NA

4 CLEC14A ROB04 EMCN ESAM NA NA NA NA NA NA 0,93945936 NA

6 CDH5 CLEC14A ROB04 EMCN ELTD1 VWF NA NA NA NA 0,93945728 NA

5 MYCT1 ROB04 VWF MMRN2 ESAM NA NA NA NA NA 0,93944814 NA

6 CLEC14A ELTD1 VWF MMRN2 ESAM KDR NA NA NA NA 0,93943628 NA

6 MYCT1 ROB04 EMCN ELTD1 VWF MMRN2 NA NA NA NA 0,93939116 NA

6 CLEC14A ROB04 EMCN ELTD1 MMRN2 KDR NA NA NA NA 0,93938348 NA

5 CDH5 MYCT1 ROB04 VWF MMRN2 NA NA NA NA NA 0,93937139 NA

6 MYCT1 ROB04 ELTD1 VWF MMRN2 ESAM NA NA NA NA 0,93926046 NA

4 CDH5 MYCT1 ROB04 EMCN NA NA NA NA NA NA 0,93922208 NA

Figure imgf000112_0001

6 CDH5 MYCT1 R0B04 EMCN ELTD1 ESAM NA NA NA NA 0,93837293 NA

5 MYCT1 R0B04 MMRN2 ESAM KDR NA NA NA NA NA 0,93836708 NA

6 CDH5 MYCT1 ELTD1 VWF MMRN2 KDR NA NA NA NA 0,93836428 NA

5 MYCT1 EMCN MMRN2 ESAM KDR NA NA NA NA NA 0,93834242 NA

4 CDH5 EMCN VWF KDR NA NA NA NA NA NA 0,93834009 NA

5 MYCT1 EMCN ELTD1 VWF ESAM NA NA NA NA NA 0,93828032 NA

6 CDH5 CLEC14A R0B04 EMCN ELTD1 KDR NA NA NA NA 0,93825992 NA

4 CDH5 MYCT1 CLEC14A MMRN2 NA NA NA NA NA NA 0,93825761 NA

6 CDH5 EMCN ELTD1 VWF MMRN2 KDR NA NA NA NA 0,9382549 NA

4 CLEC14A EMCN VWF ESAM NA NA NA NA NA NA 0,93822211 NA

5 MYCT1 CLEC14A ELTD1 VWF MMRN2 NA NA NA NA NA 0,93821964 NA

5 MYCT1 CLEC14A EMCN ELTD1 VWF NA NA NA NA NA 0,93817284 NA

6 CDH5 MYCT1 CLEC14A ELTD1 MMRN2 KDR NA NA NA NA 0,93816848 NA

4 MYCT1 EMCN MMRN2 ESAM NA NA NA NA NA NA 0,93816597 NA

5 CDH5 MYCT1 R0B04 MMRN2 KDR NA NA NA NA NA 0,93812593 NA

6 0B04 EMCN ELTD1 VWF ESAM KDR NA NA NA NA 0,93810408 NA

6 CDH5 R0B04 EMCN ELTD1 VWF ESAM NA NA NA NA 0,93810085 NA

4 CLEC14A R0B04 EMCN MMRN2 NA NA NA NA NA NA 0,93804797 NA

4 MYCT1 R0B04 MMRN2 ESAM NA NA NA NA NA NA 0,93792024 NA

4 MYCT1 CLEC14A R0B04 KDR NA NA NA NA NA NA 0,93781745 NA

6 CDH5 MYCT1 R0B04 ELTD1 MMRN2 ESAM NA NA NA NA 0,93779768 NA

6 CDH5 CLEC14A VWF MMRN2 ESAM KDR NA NA NA NA 0,93773639 NA

7 CDH5 R0B04 ELTD1 VWF MMRN2 ESAM KDR NA NA NA 0,9377159 NA

5 CDH5 MYCT1 CLEC14A ELTD1 VWF NA NA NA NA NA 0,93768218 NA

6 CLEC14A R0B04 ELTD1 VWF MMRN2 KDR NA NA NA NA 0,93767133 NA

5 CDH5 MYCT1 EMCN MMRN2 KDR NA NA NA NA NA 0,93766146 NA

4 MYCT1 R0B04 EMCN MMRN2 NA NA NA NA NA NA 0,93759428 NA

6 CDH5 CLEC14A R0B04 VWF ESAM KDR NA NA NA NA 0,93756059 NA

4 MYCT1 R0B04 VWF KDR NA NA NA NA NA NA 0,93751321 NA

6 CDH5 MYCT1 CLEC14A R0B04 ELTD1 KDR NA NA NA NA 0,93747045 NA

4 MYCT1 CLEC14A EMCN MMRN2 NA NA NA NA NA NA 0,93744774 NA

6 CDH5 CLEC14A ELTD1 VWF MMRN2 ESAM NA NA NA NA 0,93744154 NA

6 CDH5 CLEC14A R0B04 ELTD1 MMRN2 KDR NA NA NA NA 0,93738715 NA

6 0B04 EMCN ELTD1 VWF MMRN2 KDR NA NA NA NA 0,93731653 NA

6 CDH5 CLEC14A ELTD1 MMRN2 ESAM KDR NA NA NA NA 0,93730268 NA

6 MYCT1 CLEC14A EMCN ELTD1 MMRN2 KDR NA NA NA NA 0,93726227 NA

5 CDH5 CLEC14A EMCN ELTD1 VWF NA NA NA NA NA 0,93718131 NA

6 CDH5 MYCT1 CLEC14A EMCN ELTD1 KDR NA NA NA NA 0,93713796 NA

5 CDH5 MYCT1 R0B04 ESAM KDR NA NA NA NA NA 0,93710581 NA

6 MYCT1 CLEC14A R0B04 EMCN ELTD1 KDR NA NA NA NA 0,93707606 NA

5 CDH5 MYCT1 CLEC14A ELTD1 ESAM NA NA NA NA NA 0,93707601 NA

5 CDH5 EMCN MMRN2 ESAM KDR NA NA NA NA NA 0,93706356 NA

4 CLEC14A EMCN MMRN2 ESAM NA NA NA NA NA NA 0,9370607 NA

4 MYCT1 CLEC14A VWF MMRN2 NA NA NA NA NA NA 0,93704459 NA

6 CDH5 R0B04 EMCN ELTD1 VWF KDR NA NA NA NA 0,93701774 NA

6 MYCT1 R0B04 ELTD1 MMRN2 ESAM KDR NA NA NA NA 0,93697641 NA

5 MYCT1 CLEC14A R0B04 ELTD1 MMRN2 NA NA NA NA NA 0,93697145 NA

6 R0B04 EMCN ELTD1 MMRN2 ESAM KDR NA NA NA NA 0,93695372 NA

6 CDH5 R0B04 EMCN ELTD1 VWF MMRN2 NA NA NA NA 0,93692188 NA

6 CDH5 MYCT1 R0B04 ELTD1 VWF ESAM NA NA NA NA 0,93689083 NA

5 MYCT1 CLEC14A EMCN ELTD1 ESAM NA NA NA NA NA 0,93687591 NA

6 CDH5 MYCT1 R0B04 EMCN ELTD1 MMRN2 NA NA NA NA 0,936863 NA

4 CDH5 R0B04 EMCN MMRN2 NA NA NA NA NA NA 0,93686046 NA

6 CDH5 MYCT1 R0B04 ELTD1 VWF KDR NA NA NA NA 0,93681211 NA

4 R0B04 EMCN MMRN2 ESAM NA NA NA NA NA NA 0,93678282 NA

5 CLEC14A EMCN ELTD1 VWF KDR NA NA NA NA NA 0,93669565 NA

5 MYCT1 CLEC14A R0B04 ELTD1 ESAM NA NA NA NA NA 0,93667404 NA

4 CDH5 EMCN MMRN2 ESAM NA NA NA NA NA NA 0,93660731 NA

6 CLEC14A 0B04 ELTD1 VWF ESAM KDR NA NA NA NA 0,9365198 NA

6 CDH5 CLEC14A R0B04 ELTD1 VWF KDR NA NA NA NA 0,93650773 NA

5 MYCT1 ELTD1 VWF MMRN2 ESAM NA NA NA NA NA 0,93646309 NA

6 CDH5 MYCT1 R0B04 ELTD1 VWF MMRN2 NA NA NA NA 0,93644724 NA

5 CDH5 CLEC14A R0B04 MMRN2 KDR NA NA NA NA NA 0,93644539 NA

4 CDH5 CLEC14A EMCN KDR NA NA NA NA NA NA 0,93644519 NA

4 MYCT1 CLEC14A R0B04 VWF NA NA NA NA NA NA 0,93627211 NA

5 MYCT1 ELTD1 VWF ESAM KDR NA NA NA NA NA 0,93613241 NA

5 CLEC14A R0B04 EMCN ELTD1 ESAM NA NA NA NA NA 0,93607046 NA

4 CDH5 MYCT1 CLEC14A KDR NA NA NA NA NA NA 0,93605691 NA

6 CDH5 EMCN ELTD1 MMRN2 ESAM KDR NA NA NA NA 0,93602754 NA

6 CLEC14A R0B04 VWF MMRN2 ESAM KDR NA NA NA NA 0,93599834 NA

4 CDH5 MYCT1 R0B04 MMRN2 NA NA NA NA NA NA 0,9359081 NA

4 CDH5 MYCT1 R0B04 ESAM NA NA NA NA NA NA 0,93584874 NA

5 CDH5 EMCN ELTD1 VWF ESAM NA NA NA NA NA 0,93581061 NA

6 CDH5 CLEC14A R0B04 ELTD1 ESAM KDR NA NA NA NA 0,93580872 NA

4 EMCN VWF ESAM KDR NA NA NA NA NA NA 0,93573639 NA

3 CDH5 MYCT1 CLEC14A NA NA NA NA NA NA NA 0,9357346 NA

4 MYCT1 VWF MMRN2 KDR NA NA NA NA NA NA 0,93572045 NA

4 CDH5 MYCT1 EMCN MMRN2 NA NA NA NA NA NA 0,93568046 NA

5 CLEC14A R0B04 ELTD1 MMRN2 ESAM NA NA NA NA NA 0,93564801 NA

5 CDH5 CLEC14A EMCN ELTD1 MMRN2 NA NA NA NA NA 0,93562782 NA

6 MYCT1 EMCN ELTD1 MMRN2 ESAM KDR NA NA NA NA 0,93562262 NA

5 CDH5 CLEC14A R0B04 VWF KDR NA NA NA NA NA 0,93553721 NA

5 CLEC14A EMCN ELTD1 VWF MMRN2 NA NA NA NA NA 0,93543609 NA

6 CDH5 R0B04 EMCN ELTD1 ESAM KDR NA NA NA NA 0,93541382 NA

6 MYCT1 R0B04 EMCN ELTD1 ESAM KDR NA NA NA NA 0,93524129 NA

5 CDH5 CLEC14A ELTD1 MMRN2 ESAM NA NA NA NA NA 0,93516369 NA

5 CDH5 MYCT1 CLEC14A ELTD1 MMRN2 NA NA NA NA NA 0,93515621 NA

5 CDH5 CLEC14A VWF MMRN2 KDR NA NA NA NA NA 0,93515304 NA

5 CDH5 MYCT1 ELTD1 VWF ESAM NA NA NA NA NA 0,93514884 NA

6 CDH5 0B04 EMCN ELTD1 MMRN2 KDR NA NA NA NA 0,93511062 NA

5 CLEC14A R0B04 EMCN ELTD1 MMRN2 NA NA NA NA NA 0,93510461 NA

6 CLEC14A R0B04 ELTD1 VWF MMRN2 ESAM NA NA NA NA 0,93509404 NA

5 CDH5 CLEC14A VWF ESAM KDR NA NA NA NA NA 0,93504814 NA

4 CDH5 MYCT1 VWF MMRN2 NA NA NA NA NA NA 0,93504789 NA

6 CDH5 R0B04 VWF MMRN2 ESAM KDR NA NA NA NA 0,93503684 NA

4 CDH5 R0B04 EMCN VWF NA NA NA NA NA NA 0,93500802 NA

6 CDH5 MYCT1 EMCN ELTD1 ESAM KDR NA NA NA NA 0,93498168 NA

4 MYCT1 VWF MMRN2 ESAM NA NA NA NA NA NA 0,93492886 NA

6 CDH5 ELTD1 VWF MMRN2 ESAM KDR NA NA NA NA 0,93492707 NA

5 EMCN ELTD1 VWF MMRN2 ESAM NA NA NA NA NA 0,93490878 NA

5 CLEC14A ELTD1 VWF ESAM KDR NA NA NA NA NA 0,93488248 NA

4 CDH5 MYCT1 R0B04 VWF NA NA NA NA NA NA 0,93487829 NA

4 CDH5 EMCN VWF MMRN2 NA NA NA NA NA NA 0,93481776 NA

3 MYCT1 CLEC14A ESAM NA NA NA NA NA NA NA 0,9347536 NA

3 MYCT1 CLEC14A VWF NA NA NA NA NA NA NA 0,93474445 NA

5 CDH5 MYCT1 EMCN ELTD1 VWF NA NA NA NA NA 0,93468924 NA

5 CDH5 CLEC14A ELTD1 VWF KDR NA NA NA NA NA 0,93463364 NA

6 CDH5 CLEC14A R0B04 ELTD1 VWF MMRN2 NA NA NA NA 0,93452996 NA

5 CDH5 CLEC14A R0B04 MMRN2 ESAM NA NA NA NA NA 0,9345167 NA

6 CDH5 MYCT1 ELTD1 MMRN2 ESAM KDR NA NA NA NA 0,93447206 NA

5 MYCT1 R0B04 ELTD1 MMRN2 ESAM NA NA NA NA NA 0,93444493 NA

5 CDH5 MYCT1 MMRN2 ESAM KDR NA NA NA NA NA 0,93441595 NA

3 MYCT1 CLEC14A R0B04 NA NA NA NA NA NA NA 0,93437255 NA

5 EMCN ELTD1 VWF ESAM KDR NA NA NA NA NA 0,93436416 NA

6 MYCT1 R0B04 EMCN ELTD1 MMRN2 KDR NA NA NA NA 0,93435666 NA

4 CLEC14A R0B04 EMCN KDR NA NA NA NA NA NA 0,93433427 NA

5 CLEC14A ELTD1 VWF MMRN2 KDR NA NA NA NA NA 0,93432889 NA

5 MYCT1 CLEC14A ELTD1 ESAM KDR NA NA NA NA NA 0,93421203 NA

3 CDH5 CLEC14A EMCN NA NA NA NA NA NA NA 0,9342094 NA

6 0B04 ELTD1 VWF MMRN2 ESAM KDR NA NA NA NA 0,93418239 NA

6 CDH5 MYCT1 R0B04 ELTD1 MMRN2 KDR NA NA NA NA 0,93417915 NA

5 MYCT1 ELTD1 VWF MMRN2 KDR NA NA NA NA NA 0,934146 NA

5 R0B04 EMCN ELTD1 MMRN2 ESAM NA NA NA NA NA 0,93398669 NA

5 CDH5 EMCN ELTD1 MMRN2 ESAM NA NA NA NA NA 0,93395015 NA

5 MYCT1 CLEC14A R0B04 ELTD1 VWF NA NA NA NA NA 0,9339096 NA

5 CDH5 CLEC14A R0B04 EMCN ELTD1 NA NA NA NA NA 0,93388406 NA

5 MYCT1 EMCN ELTD1 VWF MMRN2 NA NA NA NA NA 0,93385763 NA

3 MYCT1 EMCN VWF NA NA NA NA NA NA NA 0,93378856 NA

6 CDH5 CLEC14A R0B04 ELTD1 VWF ESAM NA NA NA NA 0,93375528 NA

6 CDH5 CLEC14A R0B04 VWF MMRN2 ESAM NA NA NA NA 0,93369006 NA

4 CDH5 MYCT1 MMRN2 ESAM NA NA NA NA NA NA 0,93366062 NA

4 MYCT1 R0B04 VWF ESAM NA NA NA NA NA NA 0,93364923 NA

6 CDH5 MYCT1 R0B04 ELTD1 ESAM KDR NA NA NA NA 0,9335893 NA

4 R0B04 EMCN VWF KDR NA NA NA NA NA NA 0,93356131 NA

5 CDH5 MYCT1 ELTD1 VWF KDR NA NA NA NA NA 0,93348552 NA

6 CDH5 R0B04 ELTD1 VWF MMRN2 KDR NA NA NA NA 0,93347599 NA

5 CLEC14A R0B04 ELTD1 MMRN2 KDR NA NA NA NA NA 0,93340404 NA

5 CLEC14A EMCN ELTD1 ESAM KDR NA NA NA NA NA 0,93333455 NA

5 MYCT1 CLEC14A ELTD1 MMRN2 KDR NA NA NA NA NA 0,93326583 NA

5 CDH5 CLEC14A R0B04 ESAM KDR NA NA NA NA NA 0,93324364 NA

5 MYCT1 EMCN ELTD1 VWF KDR NA NA NA NA NA 0,93323106 NA

5 CLEC14A ELTD1 MMRN2 ESAM KDR NA NA NA NA NA 0,93321843 NA

5 CDH5 CLEC14A R0B04 ELTD1 MMRN2 NA NA NA NA NA 0,93316069 NA

5 CDH5 EMCN ELTD1 VWF KDR NA NA NA NA NA 0,93310811 NA

4 MYCT1 CLEC14A ESAM KDR NA NA NA NA NA NA 0,93308031 NA

6 CDH5 R0B04 ELTD1 MMRN2 ESAM KDR NA NA NA NA 0,93303266 NA

5 CDH5 MYCT1 CLEC14A EMCN ELTD1 NA NA NA NA NA 0,93302554 NA

4 MYCT1 R0B04 VWF MMRN2 NA NA NA NA NA NA 0,93301655 NA

6 CDH5 MYCT1 EMCN ELTD1 MMRN2 KDR NA NA NA NA 0,93299499 NA

6 CDH5 MYCT1 R0B04 EMCN ELTD1 KDR NA NA NA NA 0,93299057 NA

4 CLEC14A EMCN VWF MMRN2 NA NA NA NA NA NA 0,93296624 NA

4 EMCN VWF MMRN2 ESAM NA NA NA NA NA NA 0,93295376 NA

5 CLEC14A R0B04 VWF MMRN2 KDR NA NA NA NA NA 0,93289453 NA

5 MYCT1 EMCN ELTD1 MMRN2 ESAM NA NA NA NA NA 0,93288383 NA

5 MYCT1 CLEC14A EMCN ELTD1 MMRN2 NA NA NA NA NA 0,93285047 NA

5 CDH5 MYCT1 CLEC14A R0B04 ELTD1 NA NA NA NA NA 0,93284647 NA

4 CLEC14A R0B04 EMCN VWF NA NA NA NA NA NA 0,93274688 NA

4 CDH5 R0B04 EMCN KDR NA NA NA NA NA NA 0,93273761 NA

5 CDH5 CLEC14A ELTD1 VWF ESAM NA NA NA NA NA 0,93271352 NA

5 CDH5 MYCT1 ELTD1 VWF MMRN2 NA NA NA NA NA 0,93269225 NA

5 CDH5 EMCN ELTD1 VWF MMRN2 NA NA NA NA NA 0,93268441 NA

6 CDH5 R0B04 ELTD1 VWF ESAM KDR NA NA NA NA 0,93267872 NA

3 MYCT1 VWF KDR NA NA NA NA NA NA NA 0,93267395 NA

3 CDH5 MYCT1 VWF NA NA NA NA NA NA NA 0,93263951 NA

5 CLEC14A ELTD1 VWF MMRN2 ESAM NA NA NA NA NA 0,93258919 NA

4 CDH5 CLEC14A VWF KDR NA NA NA NA NA NA 0,93257849 NA

5 CLEC14A R0B04 MMRN2 ESAM KDR NA NA NA NA NA 0,93254988 NA

4 MYCT1 CLEC14A EMCN KDR NA NA NA NA NA NA 0,93243575 NA

4 0B04 EMCN VWF ESAM NA NA NA NA NA NA 0,93230593 NA

5 CDH5 MYCT1 ELTD1 MMRN2 ESAM NA NA NA NA NA 0,9322134 NA

5 MYCT1 CLEC14A R0B04 ELTD1 KDR NA NA NA NA NA 0,93221008 NA

5 CDH5 CLEC14A EMCN ELTD1 KDR NA NA NA NA NA 0,93216195 NA

4 MYCT1 CLEC14A MMRN2 KDR NA NA NA NA NA NA 0,93215965 NA

5 CDH5 MYCT1 EMCN ELTD1 ESAM NA NA NA NA NA 0,932142 NA

4 MYCT1 R0B04 MMRN2 KDR NA NA NA NA NA NA 0,93214093 NA

4 CLEC14A EMCN ESAM KDR NA NA NA NA NA NA 0,93207179 NA

5 MYCT1 R0B04 ELTD1 VWF ESAM NA NA NA NA NA 0,93203483 NA

5 CDH5 R0B04 EMCN ELTD1 ESAM NA NA NA NA NA 0,93201691 NA

6 CDH5 R0B04 ELTD1 VWF MMRN2 ESAM NA NA NA NA 0,93201008 NA

5 CLEC14A R0B04 EMCN ELTD1 VWF NA NA NA NA NA 0,93199328 NA

5 MYCT1 R0B04 ELTD1 VWF KDR NA NA NA NA NA 0,93187321 NA

5 CDH5 CLEC14A ELTD1 MMRN2 KDR NA NA NA NA NA 0,93180365 NA

5 CDH5 R0B04 VWF MMRN2 KDR NA NA NA NA NA 0,93179993 NA

5 EMCN ELTD1 VWF MMRN2 KDR NA NA NA NA NA 0,93179329 NA

4 EMCN VWF MMRN2 KDR NA NA NA NA NA NA 0,931761 NA

3 MYCT1 VWF ESAM NA NA NA NA NA NA NA 0,93168828 NA

5 CDH5 CLEC14A ELTD1 VWF MMRN2 NA NA NA NA NA 0,93166684 NA

4 CDH5 MYCT1 R0B04 KDR NA NA NA NA NA NA 0,9316454 NA

4 MYCT1 CLEC14A ELTD1 ESAM NA NA NA NA NA NA 0,93161615 NA

5 CDH5 CLEC14A R0B04 ELTD1 ESAM NA NA NA NA NA 0,93159822 NA

5 CDH5 CLEC14A ELTD1 ESAM KDR NA NA NA NA NA 0,93156479 NA

5 CDH5 MYCT1 CLEC14A ELTD1 KDR NA NA NA NA NA 0,93155625 NA

5 MYCT1 R0B04 ELTD1 VWF MMRN2 NA NA NA NA NA 0,93148635 NA

5 CLEC14A EMCN ELTD1 MMRN2 KDR NA NA NA NA NA 0,93142072 NA

4 CDH5 EMCN ESAM KDR NA NA NA NA NA NA 0,93139247 NA

5 0B04 EMCN ELTD1 VWF ESAM NA NA NA NA NA 0,93133625 NA

5 MYCT1 CLEC14A R0B04 EMCN ELTD1 NA NA NA NA NA 0,93133261 NA

5 MYCT1 R0B04 EMCN ELTD1 VWF NA NA NA NA NA 0,93130162 NA

5 CDH5 CLEC14A MMRN2 ESAM KDR NA NA NA NA NA 0,9312113 NA

4 MYCT1 CLEC14A ELTD1 VWF NA NA NA NA NA NA 0,93116444 NA

3 CDH5 EMCN ESAM NA NA NA NA NA NA NA 0,93115002 NA

5 CLEC14A R0B04 ELTD1 VWF KDR NA NA NA NA NA 0,93114244 NA

5 MYCT1 R0B04 EMCN ELTD1 ESAM NA NA NA NA NA 0,9311397 NA

4 CDH5 CLEC14A R0B04 MMRN2 NA NA NA NA NA NA 0,93101394 NA

5 CDH5 R0B04 EMCN ELTD1 MMRN2 NA NA NA NA NA 0,93098951 NA

5 CLEC14A R0B04 ELTD1 ESAM KDR NA NA NA NA NA 0,93092276 NA

4 MYCT1 R0B04 EMCN KDR NA NA NA NA NA NA 0,93082714 NA

5 CLEC14A R0B04 EMCN ELTD1 KDR NA NA NA NA NA 0,93076405 NA

4 CDH5 CLEC14A R0B04 KDR NA NA NA NA NA NA 0,93062353 NA

4 CLEC14A ELTD1 MMRN2 ESAM NA NA NA NA NA NA 0,93062299 NA

4 CDH5 MYCT1 EMCN KDR NA NA NA NA NA NA 0,93059091 NA

5 CDH5 CLEC14A R0B04 ELTD1 KDR NA NA NA NA NA 0,93044424 NA

5 CLEC14A VWF MMRN2 ESAM KDR NA NA NA NA NA 0,93033957 NA

3 CDH5 EMCN VWF NA NA NA NA NA NA NA 0,9302946 NA

4 0B04 EMCN VWF MMRN2 NA NA NA NA NA NA 0,93019789 NA

4 MYCT1 R0B04 ESAM KDR NA NA NA NA NA NA 0,93018958 NA

5 CDH5 R0B04 MMRN2 ESAM KDR NA NA NA NA NA 0,93009591 NA

5 ELTD1 VWF MMRN2 ESAM KDR NA NA NA NA NA 0,93009364 NA

5 CDH5 R0B04 VWF ESAM KDR NA NA NA NA NA 0,93008294 NA

5 CDH5 R0B04 EMCN ELTD1 VWF NA NA NA NA NA 0,93006964 NA

5 CLEC14A R0B04 VWF ESAM KDR NA NA NA NA NA 0,93006686 NA

5 R0B04 EMCN ELTD1 VWF KDR NA NA NA NA NA 0,93002825 NA

5 CDH5 VWF MMRN2 ESAM KDR NA NA NA NA NA 0,93002656 NA

4 R0B04 EMCN ESAM KDR NA NA NA NA NA NA 0,92992758 NA

5 R0B04 EMCN ELTD1 VWF MMRN2 NA NA NA NA NA 0,92991506 NA

5 CDH5 ELTD1 VWF ESAM KDR NA NA NA NA NA 0,92988114 NA

5 CDH5 MYCT1 R0B04 ELTD1 MMRN2 NA NA NA NA NA 0,9298473 NA

4 MYCT1 EMCN ESAM KDR NA NA NA NA NA NA 0,92983908 NA

4 R0B04 EMCN MMRN2 KDR NA NA NA NA NA NA 0,92978806 NA

5 CDH5 MYCT1 R0B04 ELTD1 ESAM NA NA NA NA NA 0,92970657 NA

5 CDH5 CLEC14A R0B04 VWF MMRN2 NA NA NA NA NA 0,929601 NA

5 CDH5 MYCT1 R0B04 ELTD1 VWF NA NA NA NA NA 0,92946783 NA

4 CLEC14A EMCN MMRN2 KDR NA NA NA NA NA NA 0,92936512 NA

5 CDH5 ROB04 ELTD1 MMRN2 ESAM NA NA NA NA NA 0,92928173 NA

5 CDH5 ELTD1 VWF MMRN2 KDR NA NA NA NA NA 0,92927042 NA

5 MYCT1 ROB04 EMCN ELTD1 MMRN2 NA NA NA NA NA 0,92924604 NA

4 CLEC14A EMCN ELTD1 ESAM NA NA NA NA NA NA 0,92921495 NA

5 CDH5 CLEC14A VWF MMRN2 ESAM NA NA NA NA NA 0,92920784 NA

4 MYCT1 ELTD1 VWF ESAM NA NA NA NA NA NA 0,92914658 NA

5 MYCT1 ELTD1 MMRN2 ESAM KDR NA NA NA NA NA 0,92911787 NA

5 CDH5 EMCN ELTD1 ESAM KDR NA NA NA NA NA 0,92894481 NA

3 CLEC14A EMCN ESAM NA NA NA NA NA NA NA 0,92885783 NA

5 EMCN ELTD1 MMRN2 ESAM KDR NA NA NA NA NA 0,92885 NA

5 MYCT1 ROB04 ELTD1 MMRN2 KDR NA NA NA NA NA 0,92879362 NA

4 CLEC14A ROB04 MMRN2 KDR NA NA NA NA NA NA 0,92874387 NA

5 CDH5 ELTD1 VWF MMRN2 ESAM NA NA NA NA NA 0,9287166 NA

5 CDH5 MYCT1 EMCN ELTD1 MMRN2 NA NA NA NA NA 0,92869485 NA

3 MYCT1 ROB04 MMRN2 NA NA NA NA NA NA NA 0,92863111 NA

4 CDH5 EMCN MMRN2 KDR NA NA NA NA NA NA 0,92856487 NA

3 MYCT1 ROB04 ESAM NA NA NA NA NA NA NA 0,92846544 NA

4 MYCT1 CLEC14A ELTD1 MMRN2 NA NA NA NA NA NA 0,92843849 NA

3 CDH5 MYCT1 ESAM NA NA NA NA NA NA NA 0,92835736 NA

3 CDH5 ROB04 EMCN NA NA NA NA NA NA NA 0,92833408 NA

5 CLEC14A ROB04 ELTD1 VWF MMRN2 NA NA NA NA NA 0,92833103 NA

4 CDH5 MYCT1 ESAM KDR NA NA NA NA NA NA 0,92825876 NA

5 OB04 ELTD1 MMRN2 ESAM KDR NA NA NA NA NA 0,92820068 NA

5 ROB04 VWF MMRN2 ESAM KDR NA NA NA NA NA 0,92813352 NA

5 ROB04 ELTD1 VWF MMRN2 KDR NA NA NA NA NA 0,92806498 NA

4 CDH5 CLEC14A ELTD1 ESAM NA NA NA NA NA NA 0,92805669 NA

3 MYCT1 CLEC14A MMRN2 NA NA NA NA NA NA NA 0,928026 NA

5 ROB04 EMCN ELTD1 ESAM KDR NA NA NA NA NA 0,92795046 NA

5 MYCT1 CLEC14A EMCN ELTD1 KDR NA NA NA NA NA 0,92787602 NA

3 MYCT1 EMCN ESAM NA NA NA NA NA NA NA 0,92785521 NA

3 CDH5 MYCT1 R0B04 NA NA NA NA NA NA NA 0,92784913 NA

4 CLEC14A ELTD1 VWF KDR NA NA NA NA NA NA 0,9278248 NA

5 0B04 EMCN ELTD1 MMRN2 KDR NA NA NA NA NA 0,92779503 NA

5 MYCT1 R0B04 ELTD1 ESAM KDR NA NA NA NA NA 0,92779324 NA

5 CDH5 MYCT1 R0B04 EMCN ELTD1 NA NA NA NA NA 0,9276863 NA

5 CDH5 CLEC14A R0B04 VWF ESAM NA NA NA NA NA 0,9275047 NA

5 CDH5 CLEC14A R0B04 ELTD1 VWF NA NA NA NA NA 0,92749541 NA

5 CDH5 EMCN ELTD1 MMRN2 KDR NA NA NA NA NA 0,92721129 NA

4 CLEC14A R0B04 ELTD1 MMRN2 NA NA NA NA NA NA 0,92720362 NA

4 CDH5 CLEC14A R0B04 ESAM NA NA NA NA NA NA 0,92715539 NA

4 CDH5 CLEC14A ELTD1 MMRN2 NA NA NA NA NA NA 0,92708528 NA

4 CDH5 MYCT1 MMRN2 KDR NA NA NA NA NA NA 0,92707231 NA

5 CLEC14A R0B04 ELTD1 VWF ESAM NA NA NA NA NA 0,92697187 NA

5 CDH5 MYCT1 ELTD1 ESAM KDR NA NA NA NA NA 0,92690631 NA

5 CDH5 R0B04 ELTD1 VWF KDR NA NA NA NA NA 0,92690507 NA

5 CDH5 R0B04 EMCN ELTD1 KDR NA NA NA NA NA 0,92687592 NA

5 CDH5 R0B04 ELTD1 MMRN2 KDR NA NA NA NA NA 0,9268044 NA

4 CLEC14A EMCN ELTD1 VWF NA NA NA NA NA NA 0,92678331 NA

5 R0B04 ELTD1 VWF ESAM KDR NA NA NA NA NA 0,92677554 NA

4 CDH5 CLEC14A MMRN2 KDR NA NA NA NA NA NA 0,92673654 NA

4 CDH5 CLEC14A EMCN ELTD1 NA NA NA NA NA NA 0,92664665 NA

3 CDH5 MYCT1 EMCN NA NA NA NA NA NA NA 0,92660087 NA

4 EMCN ELTD1 VWF ESAM NA NA NA NA NA NA 0,92657902 NA

5 CDH5 ELTD1 MMRN2 ESAM KDR NA NA NA NA NA 0,92650063 NA

4 MYCT1 ELTD1 VWF KDR NA NA NA NA NA NA 0,92641311 NA

5 CDH5 R0B04 VWF MMRN2 ESAM NA NA NA NA NA 0,9263534 NA

4 CDH5 CLEC14A MMRN2 ESAM NA NA NA NA NA NA 0,92626714 NA

3 CLEC14A R0B04 EMCN NA NA NA NA NA NA NA 0,92625132 NA

5 MYCT1 EMCN ELTD1 ESAM KDR NA NA NA NA NA 0,92614388 NA

5 CDH5 MYCT1 ELTD1 MMRN2 KDR NA NA NA NA NA 0,92613235 NA

4 CDH5 MYCT1 CLEC14A ELTD1 NA NA NA NA NA NA 0,92610793 NA

3 EMCN VWF ESAM NA NA NA NA NA NA NA 0,92596318 NA

5 0B04 ELTD1 VWF MMRN2 ESAM NA NA NA NA NA 0,92593938 NA

4 CDH5 R0B04 VWF KDR NA NA NA NA NA NA 0,92589297 NA

4 MYCT1 ELTD1 MMRN2 ESAM NA NA NA NA NA NA 0,92582455 NA

4 CLEC14A R0B04 VWF KDR NA NA NA NA NA NA 0,9257867 NA

4 EMCN MMRN2 ESAM KDR NA NA NA NA NA NA 0,92573038 NA

4 MYCT1 MMRN2 ESAM KDR NA NA NA NA NA NA 0,92555073 NA

5 CDH5 MYCT1 R0B04 ELTD1 KDR NA NA NA NA NA 0,92551205 NA

4 MYCT1 EMCN MMRN2 KDR NA NA NA NA NA NA 0,92541434 NA

4 CDH5 R0B04 MMRN2 KDR NA NA NA NA NA NA 0,92540143 NA

3 MYCT1 CLEC14A EMCN NA NA NA NA NA NA NA 0,92536045 NA

4 MYCT1 ELTD1 VWF MMRN2 NA NA NA NA NA NA 0,92535867 NA

3 R0B04 EMCN ESAM NA NA NA NA NA NA NA 0,9253562 NA

4 CLEC14A R0B04 MMRN2 ESAM NA NA NA NA NA NA 0,92532689 NA

4 CDH5 VWF ESAM KDR NA NA NA NA NA NA 0,92529806 NA

5 CDH5 R0B04 ELTD1 VWF MMRN2 NA NA NA NA NA 0,92526199 NA

3 CLEC14A EMCN VWF NA NA NA NA NA NA NA 0,92519606 NA

4 CDH5 MYCT1 ELTD1 VWF NA NA NA NA NA NA 0,92515174 NA

4 CDH5 CLEC14A ESAM KDR NA NA NA NA NA NA 0,92515079 NA

4 CLEC14A VWF MMRN2 KDR NA NA NA NA NA NA 0,92515046 NA

4 CLEC14A EMCN ELTD1 MMRN2 NA NA NA NA NA NA 0,92505816 NA

4 CDH5 R0B04 MMRN2 ESAM NA NA NA NA NA NA 0,92504846 NA

4 CDH5 VWF MMRN2 KDR NA NA NA NA NA NA 0,92503851 NA

5 CDH5 R0B04 ELTD1 ESAM KDR NA NA NA NA NA 0,92492251 NA

4 CDH5 EMCN ELTD1 VWF NA NA NA NA NA NA 0,92489418 NA

4 CDH5 EMCN ELTD1 ESAM NA NA NA NA NA NA 0,92482207 NA

4 CDH5 CLEC14A ELTD1 VWF NA NA NA NA NA NA 0,92476615 NA

4 CLEC14A ELTD1 VWF ESAM NA NA NA NA NA NA 0,92471646 NA

4 CLEC14A ELTD1 MMRN2 KDR NA NA NA NA NA NA 0,92456501 NA

4 MYCT1 CLEC14A R0B04 ELTD1 NA NA NA NA NA NA 0,92455528 NA

4 CLEC14A R0B04 ELTD1 ESAM NA NA NA NA NA NA 0,92449164 NA

4 EMCN ELTD1 MMRN2 ESAM NA NA NA NA NA NA 0,92449119 NA

5 CDH5 R0B04 ELTD1 VWF ESAM NA NA NA NA NA 0,92446153 NA

3 EMCN VWF KDR NA NA NA NA NA NA NA 0,92445937 NA

4 CLEC14A VWF ESAM KDR NA NA NA NA NA NA 0,92442435 NA

3 MYCT1 VWF MMRN2 NA NA NA NA NA NA NA 0,92421079 NA

5 CLEC14A R0B04 VWF MMRN2 ESAM NA NA NA NA NA 0,92412092 NA

5 CDH5 MYCT1 EMCN ELTD1 KDR NA NA NA NA NA 0,92407987 NA

4 CLEC14A ELTD1 ESAM KDR NA NA NA NA NA NA 0,92402425 NA

3 MYCT1 R0B04 VWF NA NA NA NA NA NA NA 0,92390186 NA

3 CDH5 EMCN MMRN2 NA NA NA NA NA NA NA 0,9238916 NA

3 MYCT1 MMRN2 ESAM NA NA NA NA NA NA NA 0,92384024 NA

4 MYCT1 EMCN ELTD1 VWF NA NA NA NA NA NA 0,92377635 NA

4 CDH5 CLEC14A ELTD1 KDR NA NA NA NA NA NA 0,9236679 NA

5 MYCT1 EMCN ELTD1 MMRN2 KDR NA NA NA NA NA 0,92365841 NA

5 MYCT1 R0B04 EMCN ELTD1 KDR NA NA NA NA NA 0,92364192 NA

3 MYCT1 R0B04 EMCN NA NA NA NA NA NA NA 0,92362924 NA

4 CDH5 CLEC14A VWF ESAM NA NA NA NA NA NA 0,92359238 NA

4 CLEC14A ELTD1 VWF MMRN2 NA NA NA NA NA NA 0,92325022 NA

4 CDH5 CLEC14A VWF MMRN2 NA NA NA NA NA NA 0,92320502 NA

4 CDH5 CLEC14A R0B04 ELTD1 NA NA NA NA NA NA 0,92311178 NA

3 MYCT1 CLEC14A KDR NA NA NA NA NA NA NA 0,92295257 NA

3 CDH5 MYCT1 MMRN2 NA NA NA NA NA NA NA 0,92293396 NA

4 0B04 ELTD1 MMRN2 ESAM NA NA NA NA NA NA 0,9229223 NA

4 EMCN ELTD1 VWF KDR NA NA NA NA NA NA 0,92291973 NA

3 0B04 EMCN MMRN2 NA NA NA NA NA NA NA 0,92278891 NA

4 CLEC14A R0B04 ESAM KDR NA NA NA NA NA NA 0,92275806 NA

3 CDH5 CLEC14A R0B04 NA NA NA NA NA NA NA 0,9224248 NA

4 CDH5 MYCT1 ELTD1 ESAM NA NA NA NA NA NA 0,92242152 NA

4 R0B04 VWF MMRN2 KDR NA NA NA NA NA NA 0,9224022 NA

4 CLEC14A R0B04 ELTD1 KDR NA NA NA NA NA NA 0,92234001 NA

4 CDH5 ELTD1 MMRN2 ESAM NA NA NA NA NA NA 0,92228712 NA

4 CLEC14A R0B04 EMCN ELTD1 NA NA NA NA NA NA 0,92226426 NA

4 EMCN ELTD1 VWF MMRN2 NA NA NA NA NA NA 0,92225642 NA

4 CDH5 ELTD1 VWF KDR NA NA NA NA NA NA 0,9221965 NA

4 MYCT1 CLEC14A ELTD1 KDR NA NA NA NA NA NA 0,92216294 NA

4 ELTD1 VWF ESAM KDR NA NA NA NA NA NA 0,92214704 NA

4 MYCT1 R0B04 ELTD1 MMRN2 NA NA NA NA NA NA 0,92204619 NA

4 CDH5 CLEC14A R0B04 VWF NA NA NA NA NA NA 0,9217921 NA

4 MYCT1 R0B04 ELTD1 ESAM NA NA NA NA NA NA 0,92165963 NA

4 CDH5 R0B04 ESAM KDR NA NA NA NA NA NA 0,92161204 NA

4 R0B04 EMCN ELTD1 ESAM NA NA NA NA NA NA 0,92142294 NA

4 ELTD1 VWF MMRN2 KDR NA NA NA NA NA NA 0,92137012 NA

4 CDH5 EMCN ELTD1 MMRN2 NA NA NA NA NA NA 0,92130022 NA

3 EMCN MMRN2 ESAM NA NA NA NA NA NA NA 0,9211703 NA

4 CDH5 ELTD1 VWF ESAM NA NA NA NA NA NA 0,92097317 NA

3 CLEC14A EMCN MMRN2 NA NA NA NA NA NA NA 0,92088458 NA

4 R0B04 MMRN2 ESAM KDR NA NA NA NA NA NA 0,92052169 NA

4 ELTD1 VWF MMRN2 ESAM NA NA NA NA NA NA 0,92051931 NA

4 R0B04 EMCN ELTD1 MMRN2 NA NA NA NA NA NA 0,9203009 NA

2 MYCT1 CLEC14A NA NA NA NA NA NA NA NA 0,92026271 NA

4 MYCT1 R0B04 ELTD1 VWF NA NA NA NA NA NA 0,92025403 NA

4 CDH5 MYCT1 ELTD1 MMRN2 NA NA NA NA NA NA 0,92006355 NA

4 CDH5 R0B04 ELTD1 MMRN2 NA NA NA NA NA NA 0,9199987 NA

4 MYCT1 EMCN ELTD1 ESAM NA NA NA NA NA NA 0,91980033 NA

3 CDH5 CLEC14A KDR NA NA NA NA NA NA NA 0,9197831 NA

4 CDH5 R0B04 VWF MMRN2 NA NA NA NA NA NA 0,91970008 NA

3 MYCT1 R0B04 KDR NA NA NA NA NA NA NA 0,9196892 NA

4 CLEC14A EMCN ELTD1 KDR NA NA NA NA NA NA 0,91962215 NA

4 CDH5 ELTD1 VWF MMRN2 NA NA NA NA NA NA 0,91951205 NA

4 CDH5 R0B04 EMCN ELTD1 NA NA NA NA NA NA 0,91943131 NA

3 CDH5 VWF KDR NA NA NA NA NA NA NA 0,91934565 NA

4 CDH5 VWF MMRN2 ESAM NA NA NA NA NA NA 0,91929742 NA

4 0B04 VWF ESAM KDR NA NA NA NA NA NA 0,9191966 NA

3 CDH5 CLEC14A ESAM NA NA NA NA NA NA NA 0,91919534 NA

4 CLEC14A MMRN2 ESAM KDR NA NA NA NA NA NA 0,91918063 NA

4 VWF MMRN2 ESAM KDR NA NA NA NA NA NA 0,91910602 NA

3 CDH5 CLEC14A MMRN2 NA NA NA NA NA NA NA 0,91909774 NA

4 MYCT1 CLEC14A EMCN ELTD1 NA NA NA NA NA NA 0,91895618 NA

3 CDH5 EMCN KDR NA NA NA NA NA NA NA 0,91880695 NA

4 R0B04 ELTD1 MMRN2 KDR NA NA NA NA NA NA 0,91862566 NA

3 CLEC14A ELTD1 ESAM NA NA NA NA NA NA NA 0,91860702 NA

4 CDH5 MMRN2 ESAM KDR NA NA NA NA NA NA 0,91852751 NA

3 R0B04 EMCN VWF NA NA NA NA NA NA NA 0,91848837 NA

4 R0B04 EMCN ELTD1 VWF NA NA NA NA NA NA 0,91828265 NA

3 EMCN VWF MMRN2 NA NA NA NA NA NA NA 0,91820108 NA

4 CDH5 R0B04 ELTD1 ESAM NA NA NA NA NA NA 0,91811193 NA

3 CLEC14A VWF KDR NA NA NA NA NA NA NA 0,91804401 NA

4 ELTD1 MMRN2 ESAM KDR NA NA NA NA NA NA 0,91798265 NA

3 CLEC14A R0B04 MMRN2 NA NA NA NA NA NA NA 0,91780281 NA

4 R0B04 ELTD1 VWF KDR NA NA NA NA NA NA 0,91769897 NA

3 CDH5 R0B04 MMRN2 NA NA NA NA NA NA NA 0,91759715 NA

4 CDH5 R0B04 VWF ESAM NA NA NA NA NA NA 0,91750704 NA

4 CDH5 MYCT1 R0B04 ELTD1 NA NA NA NA NA NA 0,91749643 NA

3 CDH5 MYCT1 KDR NA NA NA NA NA NA NA 0,91747047 NA

3 MYCT1 EMCN MMRN2 NA NA NA NA NA NA NA 0,91724348 NA

4 CDH5 ELTD1 MMRN2 KDR NA NA NA NA NA NA 0,91692304 NA

2 MYCT1 VWF NA NA NA NA NA NA NA NA 0,91690376 NA

4 MYCT1 ELTD1 ESAM KDR NA NA NA NA NA NA 0,91678096 NA

3 CLEC14A EMCN KDR NA NA NA NA NA NA NA 0,91670863 NA

3 CLEC14A ELTD1 MMRN2 NA NA NA NA NA NA NA 0,91670177 NA

4 EMCN ELTD1 ESAM KDR NA NA NA NA NA NA 0,91662356 NA

4 CDH5 ELTD1 ESAM KDR NA NA NA NA NA NA 0,91653079 NA

3 CLEC14A R0B04 KDR NA NA NA NA NA NA NA 0,9165135 NA

4 CLEC14A R0B04 ELTD1 VWF NA NA NA NA NA NA 0,91650836 NA

4 CDH5 EMCN ELTD1 KDR NA NA NA NA NA NA 0,91624949 NA

4 CDH5 MYCT1 EMCN ELTD1 NA NA NA NA NA NA 0,91621518 NA

3 CDH5 CLEC14A VWF NA NA NA NA NA NA NA 0,91600544 NA

4 CLEC14A R0B04 VWF MMRN2 NA NA NA NA NA NA 0,91594231 NA

4 MYCT1 ELTD1 MMRN2 KDR NA NA NA NA NA NA 0,91584721 NA

3 0B04 EMCN KDR NA NA NA NA NA NA NA 0,91555621 NA

4 CDH5 R0B04 ELTD1 KDR NA NA NA NA NA NA 0,91553749 NA

3 CDH5 CLEC14A ELTD1 NA NA NA NA NA NA NA 0,91553436 NA

4 R0B04 ELTD1 ESAM KDR NA NA NA NA NA NA 0,91543479 NA

4 R0B04 ELTD1 VWF MMRN2 NA NA NA NA NA NA 0,91527889 NA

4 MYCT1 EMCN ELTD1 MMRN2 NA NA NA NA NA NA 0,91509437 NA

4 MYCT1 R0B04 ELTD1 KDR NA NA NA NA NA NA 0,91486279 NA

4 CDH5 R0B04 ELTD1 VWF NA NA NA NA NA NA 0,9146149 NA

4 CDH5 MYCT1 ELTD1 KDR NA NA NA NA NA NA 0,91459786 NA

4 EMCN ELTD1 MMRN2 KDR NA NA NA NA NA NA 0,91453956 NA

3 CDH5 R0B04 KDR NA NA NA NA NA NA NA 0,91452826 NA

4 CLEC14A VWF MMRN2 ESAM NA NA NA NA NA NA 0,91450867 NA

4 0B04 EMCN ELTD1 KDR NA NA NA NA NA NA 0,91401332 NA

4 R0B04 ELTD1 VWF ESAM NA NA NA NA NA NA 0,91371236 NA

4 MYCT1 R0B04 EMCN ELTD1 NA NA NA NA NA NA 0,91351631 NA

4 R0B04 VWF MMRN2 ESAM NA NA NA NA NA NA 0,9131418 NA

3 CDH5 R0B04 ESAM NA NA NA NA NA NA NA 0,91312984 NA

2 CDH5 CLEC14A NA NA NA NA NA NA NA NA 0,91245826 NA

3 MYCT1 ESAM KDR NA NA NA NA NA NA NA 0,91237687 NA

2 CDH5 MYCT1 NA NA NA NA NA NA NA NA 0,91233465 NA

2 MYCT1 ESAM NA NA NA NA NA NA NA NA 0,91191026 NA

3 EMCN ESAM KDR NA NA NA NA NA NA NA 0,91179525 NA

3 MYCT1 ELTD1 VWF NA NA NA NA NA NA NA 0,9117497 NA

4 CLEC14A R0B04 VWF ESAM NA NA NA NA NA NA 0,91158058 NA

3 R0B04 MMRN2 KDR NA NA NA NA NA NA NA 0,91139928 NA

3 ELTD1 MMRN2 ESAM NA NA NA NA NA NA NA 0,91128304 NA

3 MYCT1 CLEC14A ELTD1 NA NA NA NA NA NA NA 0,91120688 NA

3 CDH5 MMRN2 ESAM NA NA NA NA NA NA NA 0,91103082 NA

3 MYCT1 MMRN2 KDR NA NA NA NA NA NA NA 0,91097175 NA

2 MYCT1 R0B04 NA NA NA NA NA NA NA NA 0,91089719 NA

3 R0B04 MMRN2 ESAM NA NA NA NA NA NA NA 0,9106965 NA

2 CDH5 EMCN NA NA NA NA NA NA NA NA 0,91067285 NA

3 R0B04 VWF KDR NA NA NA NA NA NA NA 0,91044543 NA

3 CDH5 VWF ESAM NA NA NA NA NA NA NA 0,91013186 NA

3 CLEC14A ELTD1 VWF NA NA NA NA NA NA NA 0,91009358 NA

3 CLEC14A ELTD1 KDR NA NA NA NA NA NA NA 0,90974476 NA

3 CLEC14A R0B04 ELTD1 NA NA NA NA NA NA NA 0,90913436 NA

3 ELTD1 VWF KDR NA NA NA NA NA NA NA 0,9089695 NA

3 VWF MMRN2 KDR NA NA NA NA NA NA NA 0,90892549 NA

3 CDH5 VWF MMRN2 NA NA NA NA NA NA NA 0,90881077 NA

3 CLEC14A R0B04 ESAM NA NA NA NA NA NA NA 0,90881042 NA

3 CLEC14A MMRN2 KDR NA NA NA NA NA NA NA 0,90877322 NA

3 CDH5 ELTD1 ESAM NA NA NA NA NA NA NA 0,90871893 NA

3 MYCT1 EMCN KDR NA NA NA NA NA NA NA 0,90863889 NA

3 CDH5 MMRN2 KDR NA NA NA NA NA NA NA 0,90858666 NA

3 VWF ESAM KDR NA NA NA NA NA NA NA 0,90852806 NA

3 EMCN MMRN2 KDR NA NA NA NA NA NA NA 0,90830944 NA

3 MYCT1 ELTD1 ESAM NA NA NA NA NA NA NA 0,90824147 NA

4 MYCT1 EMCN ELTD1 KDR NA NA NA NA NA NA 0,90819825 NA

3 CDH5 ELTD1 MMRN2 NA NA NA NA NA NA NA 0,90750458 NA

3 CDH5 R0B04 VWF NA NA NA NA NA NA NA 0,9074924 NA

3 CDH5 ELTD1 VWF NA NA NA NA NA NA NA 0,90732163 NA

3 0B04 ELTD1 MMRN2 NA NA NA NA NA NA NA 0,90719958 NA

3 EMCN ELTD1 VWF NA NA NA NA NA NA NA 0,90709586 NA

3 CLEC14A MMRN2 ESAM NA NA NA NA NA NA NA 0,90689791 NA

3 CDH5 ESAM KDR NA NA NA NA NA NA NA 0,90668723 NA

3 ELTD1 VWF ESAM NA NA NA NA NA NA NA 0,90662586 NA

3 EMCN ELTD1 ESAM NA NA NA NA NA NA NA 0,9066257 NA

3 CLEC14A EMCN ELTD1 NA NA NA NA NA NA NA 0,90631056 NA

3 CDH5 EMCN ELTD1 NA NA NA NA NA NA NA 0,90515981 NA

3 ELTD1 VWF MMRN2 NA NA NA NA NA NA NA 0,90455281 NA

3 MYCT1 ELTD1 MMRN2 NA NA NA NA NA NA NA 0,90437475 NA

3 CLEC14A ESAM KDR NA NA NA NA NA NA NA 0,90433347 NA

3 R0B04 ELTD1 ESAM NA NA NA NA NA NA NA 0,9034972 NA

3 R0B04 ESAM KDR NA NA NA NA NA NA NA 0,90348252 NA

3 CDH5 MYCT1 ELTD1 NA NA NA NA NA NA NA 0,90285149 NA

3 CDH5 R0B04 ELTD1 NA NA NA NA NA NA NA 0,90276478 NA

3 EMCN ELTD1 MMRN2 NA NA NA NA NA NA NA 0,90172161 NA

3 CDH5 ELTD1 KDR NA NA NA NA NA NA NA 0,90158305 NA

2 EMCN VWF NA NA NA NA NA NA NA NA 0,9015645 NA

3 ELTD1 MMRN2 KDR NA NA NA NA NA NA NA 0,9013759 NA

2 EMCN ESAM NA NA NA NA NA NA NA NA 0,9011035 NA

2 CDH5 R0B04 NA NA NA NA NA NA NA NA 0,90091545 NA

3 CLEC14A VWF MMRN2 NA NA NA NA NA NA NA 0,90021093 NA

3 ELTD1 ESAM KDR NA NA NA NA NA NA NA 0,90019699 NA

3 MYCT1 R0B04 ELTD1 NA NA NA NA NA NA NA 0,8997477 NA

3 0B04 VWF MMRN2 NA NA NA NA NA NA NA 0,89931522 NA

3 CLEC14A VWF ESAM NA NA NA NA NA NA NA 0,89920602 NA

3 R0B04 ELTD1 KDR NA NA NA NA NA NA NA 0,89895552 NA

3 R0B04 EMCN ELTD1 NA NA NA NA NA NA NA 0,89855208 NA

2 MYCT1 MMRN2 NA NA NA NA NA NA NA NA 0,89827157 NA

2 CLEC14A EMCN NA NA NA NA NA NA NA NA 0,89821565 NA

2 R0B04 EMCN NA NA NA NA NA NA NA NA 0,89815234 NA

3 MMRN2 ESAM KDR NA NA NA NA NA NA NA 0,89755214 NA

3 CLEC14A R0B04 VWF NA NA NA NA NA NA NA 0,89748337 NA

3 VWF MMRN2 ESAM NA NA NA NA NA NA NA 0,89739321 NA

3 R0B04 ELTD1 VWF NA NA NA NA NA NA NA 0,89614154 NA

2 CDH5 ESAM NA NA NA NA NA NA NA NA 0,89604425 NA

2 CDH5 VWF NA NA NA NA NA NA NA NA 0,89486425 NA

3 MYCT1 ELTD1 KDR NA NA NA NA NA NA NA 0,89457256 NA

2 CDH5 MMRN2 NA NA NA NA NA NA NA NA 0,894274 NA

3 R0B04 VWF ESAM NA NA NA NA NA NA NA 0,89402575 NA

2 CLEC14A R0B04 NA NA NA NA NA NA NA NA 0,89384616 NA

3 EMCN ELTD1 KDR NA NA NA NA NA NA NA 0,89366594 NA

2 R0B04 MMRN2 NA NA NA NA NA NA NA NA 0,89333345 NA

2 VWF KDR NA NA NA NA NA NA NA NA 0,89312099 NA

2 CLEC14A ELTD1 NA NA NA NA NA NA NA NA 0,89182554 NA

2 CDH5 KDR NA NA NA NA NA NA NA NA 0,89099562 NA

3 MYCT1 EMCN ELTD1 NA NA NA NA NA NA NA 0,89057525 NA

2 EMCN MMRN2 NA NA NA NA NA NA NA NA 0,88884145 NA

2 MYCT1 EMCN NA NA NA NA NA NA NA NA 0,88766629 NA

2 CLEC14A KDR NA NA NA NA NA NA NA NA 0,88630496 NA

2 OB04 KDR NA NA NA NA NA NA NA NA 0,88538769 NA

2 MYCT1 KDR NA NA NA NA NA NA NA NA 0,88482122 NA

2 CLEC14A MMRN2 NA NA NA NA NA NA NA NA 0,88465989 NA

2 ELTD1 ESAM NA NA NA NA NA NA NA NA 0,88347355 NA

2 CDH5 ELTD1 NA NA NA NA NA NA NA NA 0,88266272 NA

2 CLEC14A ESAM NA NA NA NA NA NA NA NA 0,88175597 NA

2 ELTD1 MMRN2 NA NA NA NA NA NA NA NA 0,88150174 NA

2 ROB04 ESAM NA NA NA NA NA NA NA NA 0,88064887 NA

2 EMCN KDR NA NA NA NA NA NA NA NA 0,8797142 NA

2 ELTD1 VWF NA NA NA NA NA NA NA NA 0,87860586 NA

2 MMRN2 ESAM NA NA NA NA NA NA NA NA 0,87518214 NA

2 CLEC14A VWF NA NA NA NA NA NA NA NA 0,8736913 NA

2 MMRN2 KDR NA NA NA NA NA NA NA NA 0,8719394 NA

2 ROB04 ELTD1 NA NA NA NA NA NA NA NA 0,87144527 NA

1 CDH5 NA NA NA NA NA NA NA NA NA 0,87032191 NA

2 VWF MMRN2 NA NA NA NA NA NA NA NA 0,87020244 NA

2 VWF ESAM NA NA NA NA NA NA NA NA 0,86980472 NA

2 ELTD1 KDR NA NA NA NA NA NA NA NA 0,86904557 NA

2 ROB04 VWF NA NA NA NA NA NA NA NA 0,86726902 NA

2 MYCT1 ELTD1 NA NA NA NA NA NA NA NA 0,86603126 NA

2 EMCN ELTD1 NA NA NA NA NA NA NA NA 0,8649421 NA

2 ESAM KDR NA NA NA NA NA NA NA NA 0,86451601 NA

1 MYCT1 NA NA NA NA NA NA NA NA NA 0,85302037 NA

1 CLEC14A NA NA NA NA NA NA NA NA NA 0,84250894 NA

1 ROB04 NA NA NA NA NA NA NA NA NA 0,83326816 NA

1 EMCN NA NA NA NA NA NA NA NA NA 0,82244472 NA

1 ELTD1 NA NA NA NA NA NA NA NA NA 0,81000417 NA

1 VWF NA NA NA NA NA NA NA NA NA 0,80805535 NA

1 MM N2 NA NA NA NA NA NA NA NA NA 0,80739173 NA

1 ESAM NA NA NA NA NA NA NA NA NA 0,80377646 NA

1 KDR NA NA NA NA NA NA NA NA NA 0,79939504 NA

Combination of genes for identification of fibroblasts

8 COL3A1 DCN COL6A2 COL1A1 TAGLN GREM1 COL6A1 PAMR1 NA NA 0,98748089 NA

7 COL3A1 DCN COL6A2 TAGLN GREM1 COL6A1 PAMR1 NA NA NA 0,98703574 NA

7 COL3A1 DCN COL1A1 TAGLN GREM1 COL6A1 PAMR1 NA NA NA 0,98687787 NA

6 COL3A1 DCN COL6A2 TAGLN GREM1 COL6A1 NA NA NA NA 0,98677766 NA

7 DCN COL6A2 COL1A1 TAGLN GREM1 COL6A1 PAMR1 NA NA NA 0,98672411 NA

6 COL3A1 DCN COL6A2 GREM1 COL6A1 PAMR1 NA NA NA NA 0,98630978 NA

6 DCN COL6A2 COL1A1 TAGLN GREM1 COL6A1 NA NA NA NA 0,98515393 NA

6 DCN COL1A1 TAGLN GREM1 COL6A1 PAMR1 NA NA NA NA 0,98490474 NA

5 COL3A1 DCN COL6A2 GREM1 COL6A1 NA NA NA NA NA 0,98489106 NA

7 COL3A1 DCN COL6A2 COL1A1 TAGLN GREM1 COL6A1 NA NA NA 0,98441795 NA

5 COL3A1 DCN TAGLN GREM1 COL6A1 NA NA NA NA NA 0,98385045 NA

7 COL3A1 DCN COL6A2 COL1A1 GREM1 COL6A1 PAMR1 NA NA NA 0,98367252 NA

5 DCN COL1A1 TAGLN GREM1 COL6A1 NA NA NA NA NA 0,98354233 NA

6 COL3A1 DCN COL1A1 TAGLN GREM1 COL6A1 NA NA NA NA 0,98335192 NA

6 COL3A1 DCN TAGLN GREM1 COL6A1 PAMR1 NA NA NA NA 0,98333136 NA

6 DCN COL6A2 COL1A1 GREM1 COL6A1 PAMR1 NA NA NA NA 0,98207789 NA

6 COL3A1 DCN COL1A1 GREM1 COL6A1 PAMR1 NA NA NA NA 0,98139739 NA

5 DCN COL6A2 TAGLN GREM1 COL6A1 NA NA NA NA NA 0,9808085 NA

6 DCN COL6A2 COL1A1 TAGLN GREM1 PAMR1 NA NA NA NA 0,98064696 NA

5 C0L3A1 DCN G EM1 COL6A1 PAMR1 NA NA NA NA NA 0,98055719 NA

7 C0L3A1 DCN COL6A2 COL1A1 TAGLN GREM1 PAMR1 NA NA NA 0,98045963 NA

4 C0L3A1 DCN GREM1 COL6A1 NA NA NA NA NA NA 0,97967789 NA

6 C0L3A1 DCN COL6A2 COL1A1 GREM1 COL6A1 NA NA NA NA 0,97900842 NA

5 DCN COL6A2 COL1A1 GREM1 COL6A1 NA NA NA NA NA 0,97886714 NA

6 C0L3A1 DCN COL6A2 TAGLN GREM1 PAMR1 NA NA NA NA 0,97847942 NA

5 C0L3A1 DCN COL6A2 GREM1 PAMR1 NA NA NA NA NA 0,97833602 NA

5 DCN COL6A2 COL1A1 TAGLN GREM1 NA NA NA NA NA 0,97732209 NA

5 DCN C0L1A1 GREM1 COL6A1 PAMR1 NA NA NA NA NA 0,97716968 NA

4 DCN COL6A2 GREM1 COL6A1 NA NA NA NA NA NA 0,97708011 NA

6 DCN COL6A2 TAGLN GREM1 COL6A1 PAMR1 NA NA NA NA 0,97686705 NA

5 C0L3A1 DCN COL6A2 TAGLN GREM1 NA NA NA NA NA 0,97662971 NA

5 DCN COL6A2 COL1A1 GREM1 PAMR1 NA NA NA NA NA 0,97653712 NA

4 DCN COL1A1 TAGLN COL6A1 NA NA NA NA NA NA 0,97628668 NA

6 C0L3A1 DCN COL6A2 COL1A1 GREM1 PAMR1 NA NA NA NA 0,97627316 NA

6 C0L3A1 DCN COL6A2 COL1A1 TAGLN GREM1 NA NA NA NA 0,97591219 NA

5 C0L3A1 DCN COL1A1 GREM1 COL6A1 NA NA NA NA NA 0,97564524 NA

4 C0L3A1 DCN COL6A2 GREM1 NA NA NA NA NA NA 0,9743702 NA

6 C0L3A1 DCN COL1A1 TAGLN COL6A1 PAMR1 NA NA NA NA 0,97431503 NA

4 C0L3A1 DCN TAGLN COL6A1 NA NA NA NA NA NA 0,97428815 NA

5 C0L3A1 DCN COL1A1 TAGLN COL6A1 NA NA NA NA NA 0,97412009 NA

4 DCN COL1A1 GREM1 COL6A1 NA NA NA NA NA NA 0,97352977 NA

5 DCN COL6A2 GREM1 COL6A1 PAMR1 NA NA NA NA NA 0,97286973 NA

4 DCN TAGLN GREM1 COL6A1 NA NA NA NA NA NA 0,97133746 NA

7 C0L3A1 DCN COL6A2 COL1A1 TAGLN COL6A1 PAMR1 NA NA NA 0,97114255 NA

6 C0L3A1 DCN COL1A1 TAGLN GREM1 PAMR1 NA NA NA NA 0,97060549 NA

4 DCN COL6A2 COL1A1 GREM1 NA NA NA NA NA NA 0,97052176 NA

7 C0L3A1 COL6A2 COL1A1 TAGLN GREM1 COL6A1 PAMR1 NA NA NA 0,97046408 NA

6 C0L3A1 DCN COL6A2 COL1A1 TAGLN COL6A1 NA NA NA NA 0,97031481 NA

4 DCN COL6A2 TAGLN GREM1 NA NA NA NA NA NA 0,97027025 NA

5 DCN C0L1A1 TAGLN COL6A1 PAMR1 NA NA NA NA NA 0,96999158 NA

4 DCN COL6A2 COL1A1 TAGLN NA NA NA NA NA NA 0,96963305 NA

5 C0L3A1 DCN COL6A2 COL1A1 GREM1 NA NA NA NA NA 0,96943131 NA

5 C0L3A1 DCN COL6A2 TAGLN COL6A1 NA NA NA NA NA 0,96914521 NA

6 C0L3A1 COL1A1 TAGLN GREM1 COL6A1 PAMR1 NA NA NA NA 0,96892682 NA

5 DCN COL6A2 COL1A1 TAGLN COL6A1 NA NA NA NA NA 0,96888356 NA

6 C0L3A1 DCN COL6A2 COL1A1 TAGLN PAMR1 NA NA NA NA 0,96820773 NA

5 DCN COL6A2 COL1A1 TAGLN PAMR1 NA NA NA NA NA 0,96791127 NA

3 DCN COL6A2 G EM1 NA NA NA NA NA NA NA 0,96768148 NA

5 DCN COL6A2 TAGLN GREM1 PAMR1 NA NA NA NA NA 0,96767375 NA

4 C0L3A1 DCN COL6A2 TAGLN NA NA NA NA NA NA 0,96654728 NA

6 C0L3A1 COL6A2 TAGLN GREM1 COL6A1 PAMR1 NA NA NA NA 0,96637394 NA

6 DCN COL6A2 COL1A1 TAGLN COL6A1 PAMR1 NA NA NA NA 0,96606262 NA

5 C0L3A1 DCN COL6A2 COL1A1 TAGLN NA NA NA NA NA 0,96591671 NA

4 DCN COL6A2 GREM1 PAMR1 NA NA NA NA NA NA 0,96570927 NA

6 C0L3A1 COL6A2 COL1A1 TAGLN GREM1 COL6A1 NA NA NA NA 0,96567334 NA

5 DCN COL1A1 TAGLN GREM1 PAMR1 NA NA NA NA NA 0,96516787 NA

5 C0L3A1 DCN COL1A1 TAGLN GREM1 NA NA NA NA NA 0,96504063 NA

5 C0L3A1 COL6A2 TAGLN GREM1 COL6A1 NA NA NA NA NA 0,96467781 NA

5 C0L3A1 DCN TAGLN COL6A1 PAMR1 NA NA NA NA NA 0,96448792 NA

6 C0L3A1 DCN COL6A2 TAGLN COL6A1 PAMR1 NA NA NA NA 0,96418565 NA

5 DCN TAGLN GREM1 COL6A1 PAMR1 NA NA NA NA NA 0,96387452 NA

3 DCN COL1A1 TAGLN NA NA NA NA NA NA NA 0,96322604 NA

5 C0L3A1 COL1A1 TAGLN GREM1 COL6A1 NA NA NA NA NA 0,9630006 NA

6 C0L3A1 COL6A2 COL1A1 GREM1 COL6A1 PAMR1 NA NA NA NA 0,96295163 NA

5 C0L3A1 DCN COL6A2 TAGLN PAMR1 NA NA NA NA NA 0,96223877 NA

6 COL6A2 COL1A1 TAGLN GREM1 COL6A1 PAMR1 NA NA NA NA 0,9619288 NA

5 C0L3A1 COL6A2 GREM1 COL6A1 PAMR1 NA NA NA NA NA 0,96175541 NA

5 C0L3A1 DCN COL1A1 TAGLN PAMR1 NA NA NA NA NA 0,96168604 NA

5 C0L3A1 DCN COL1A1 GREM1 PAMR1 NA NA NA NA NA 0,96130763 NA

4 DCN COL1A1 TAGLN GREM1 NA NA NA NA NA NA 0,96120814 NA

6 C0L3A1 COL6A2 COL1A1 TAGLN GREM1 PAMR1 NA NA NA NA 0,96104721 NA

3 DCN COL6A2 TAGLN NA NA NA NA NA NA NA 0,96088165 NA

3 C0L3A1 DCN COL6A1 NA NA NA NA NA NA NA 0,96071581 NA

5 C0L3A1 TAGLN GREM1 COL6A1 PAMR1 NA NA NA NA NA 0,96035866 NA

5 C0L3A1 DCN COL1A1 COL6A1 PAMR1 NA NA NA NA NA 0,96024725 NA

6 C0L3A1 DCN COL6A2 COL1A1 COL6A1 PAMR1 NA NA NA NA 0,95990086 NA

3 DCN G EM1 COL6A1 NA NA NA NA NA NA NA 0,95952027 NA

4 C0L3A1 DCN COL1A1 TAGLN NA NA NA NA NA NA 0,95935173 NA

4 C0L3A1 TAGLN GREM1 COL6A1 NA NA NA NA NA NA 0,9591337 NA

5 C0L3A1 DCN TAGLN GREM1 PAMR1 NA NA NA NA NA 0,95890371 NA

5 C0L3A1 COL1A1 GREM1 COL6A1 PAMR1 NA NA NA NA NA 0,95864066 NA

3 C0L3A1 DCN COL6A2 NA NA NA NA NA NA NA 0,95859533 NA

5 COL6A2 COL1A1 TAGLN GREM1 COL6A1 NA NA NA NA NA 0,95847694 NA

4 DCN COL1A1 TAGLN PAMR1 NA NA NA NA NA NA 0,95845269 NA

4 C0L3A1 DCN COL1A1 COL6A1 NA NA NA NA NA NA 0,95830455 NA

5 C0L3A1 DCN COL6A2 COL1A1 COL6A1 NA NA NA NA NA 0,95772678 NA

4 C0L3A1 COL6A2 GREM1 COL6A1 NA NA NA NA NA NA 0,9576986 NA

5 C0L3A1 DCN COL6A2 COL1A1 PAMR1 NA NA NA NA NA 0,95758413 NA

4 C0L3A1 DCN COL6A2 COL6A1 NA NA NA NA NA NA 0,95744538 NA

4 C0L3A1 DCN TAGLN GREM1 NA NA NA NA NA NA 0,95701642 NA

3 DCN TAGLN COL6A1 NA NA NA NA NA NA NA 0,95655887 NA

5 C0L1A1 TAGLN GREM1 COL6A1 PAMR1 NA NA NA NA NA 0,95629249 NA

5 COL3A1 COL6A2 COL1A1 GREM1 COL6A1 NA NA NA NA NA 0,95558815 NA

3 DCN COL6A2 COL1A1 NA NA NA NA NA NA NA 0,95522341 NA

4 DCN COL6A2 TAGLN COL6A1 NA NA NA NA NA NA 0,95493096 NA

4 DCN COL6A2 COL1A1 PAMR1 NA NA NA NA NA NA 0,95489213 NA

5 C0L3A1 COL6A2 TAGLN GREM1 PAMR1 NA NA NA NA NA 0,95423575 NA

5 C0L3A1 COL6A2 COL1A1 TAGLN GREM1 NA NA NA NA NA 0,95406496 NA

4 C0L3A1 DCN COL6A2 PAMR1 NA NA NA NA NA NA 0,95400579 NA

3 DCN COL1A1 COL6A1 NA NA NA NA NA NA NA 0,95393406 NA

2 DCN COL6A2 NA NA NA NA NA NA NA NA 0,95374738 NA

3 C0L3A1 DCN TAGLN NA NA NA NA NA NA NA 0,95348528 NA

4 C0L3A1 DCN COL6A2 COL1A1 NA NA NA NA NA NA 0,95309931 NA

5 C0L3A1 COL6A2 COL1A1 GREM1 PAMR1 NA NA NA NA NA 0,9524695 NA

4 C0L3A1 G EM1 COL6A1 PAMR1 NA NA NA NA NA NA 0,9524691 NA

4 C0L3A1 DCN COL1A1 GREM1 NA NA NA NA NA NA 0,95243674 NA

5 C0L3A1 COL1A1 TAGLN COL6A1 PAMR1 NA NA NA NA NA 0,95237538 NA

4 C0L1A1 TAGLN GREM1 COL6A1 NA NA NA NA NA NA 0,95232737 NA

5 COL6A2 COL1A1 TAGLN GREM1 PAMR1 NA NA NA NA NA 0,95223474 NA

5 COL3A1 DCN COL6A2 COL6A1 PAMR1 NA NA NA NA NA 0,95190983 NA

4 DCN COL6A2 COL1A1 COL6A1 NA NA NA NA NA NA 0,9515609 NA

4 DCN COL1A1 GREM1 PAMR1 NA NA NA NA NA NA 0,95136168 NA

4 COL3A1 COL1A1 TAGLN COL6A1 NA NA NA NA NA NA 0,95033335 NA

4 DCN GREM1 COL6A1 PAMR1 NA NA NA NA NA NA 0,95014847 NA

4 COL3A1 COL6A2 TAGLN GREM1 NA NA NA NA NA NA 0,94994314 NA

4 COL3A1 COL6A2 GREM1 PAMR1 NA NA NA NA NA NA 0,94988879 NA

5 COL6A2 COL1A1 GREM1 COL6A1 PAMR1 NA NA NA NA NA 0,94982521 NA

5 DCN COL6A2 COL1A1 COL6A1 PAMR1 NA NA NA NA NA 0,94930077 NA

4 COL3A1 DCN GREM1 PAMR1 NA NA NA NA NA NA 0,94886323 NA

4 COL3A1 COL1A1 GREM1 COL6A1 NA NA NA NA NA NA 0,94880297 NA

6 COL3A1 COL6A2 COL1A1 TAGLN COL6A1 PAMR1 NA NA NA NA 0,94840492 NA

3 COL3A1 TAGLN COL6A1 NA NA NA NA NA NA NA 0,94781316 NA

3 COL3A1 GREM1 COL6A1 NA NA NA NA NA NA NA 0,94776681 NA

4 COL3A1 DCN COL6A1 PAMR1 NA NA NA NA NA NA 0,94764475 NA

4 DCN COL1A1 COL6A1 PAMR1 NA NA NA NA NA NA 0,94714053 NA

5 C0L3A1 COL1A1 TAGLN GREM1 PAMR1 NA NA NA NA NA 0,94663626 NA

5 C0L3A1 COL6A2 COL1A1 TAGLN COL6A1 NA NA NA NA NA 0,94608589 NA

4 COL6A2 COL1A1 TAGLN GREM1 NA NA NA NA NA NA 0,94595759 NA

4 C0L3A1 DCN TAGLN PAMR1 NA NA NA NA NA NA 0,94455151 NA

5 C0L3A1 COL6A2 COL1A1 TAGLN PAMR1 NA NA NA NA NA 0,94421809 NA

4 C0L3A1 DCN COL1A1 PAMR1 NA NA NA NA NA NA 0,94395132 NA

3 C0L3A1 DCN GREM1 NA NA NA NA NA NA NA 0,9438397 NA

4 COL6A2 COL1A1 GREM1 COL6A1 NA NA NA NA NA NA 0,94333321 NA

3 DCN COL1A1 GREM1 NA NA NA NA NA NA NA 0,94328335 NA

4 COL6A2 TAGLN GREM1 COL6A1 NA NA NA NA NA NA 0,94240516 NA

4 DCN COL6A2 TAGLN PAMR1 NA NA NA NA NA NA 0,94237719 NA

4 C0L3A1 COL6A2 COL1A1 GREM1 NA NA NA NA NA NA 0,9416854 NA

3 C0L3A1 COL6A2 GREM1 NA NA NA NA NA NA NA 0,94116806 NA

5 DCN COL6A2 TAGLN COL6A1 PAMR1 NA NA NA NA NA 0,93979307 NA

4 C0L3A1 COL6A2 COL1A1 TAGLN NA NA NA NA NA NA 0,9395262 NA

4 COL6A2 COL1A1 GREM1 PAMR1 NA NA NA NA NA NA 0,93929814 NA

5 COL6A2 TAGLN GREM1 COL6A1 PAMR1 NA NA NA NA NA 0,9390932 NA

4 C0L3A1 COL6A2 TAGLN COL6A1 NA NA NA NA NA NA 0,93865388 NA

3 C0L3A1 DCN COL1A1 NA NA NA NA NA NA NA 0,93835459 NA

3 C0L1A1 TAGLN COL6A1 NA NA NA NA NA NA NA 0,93808014 NA

4 COL3A1 COL1A1 TAGLN GREM1 NA NA NA NA NA NA 0,93754802 NA

4 COL1A1 G EM1 COL6A1 PAMR1 NA NA NA NA NA NA 0,93679432 NA

2 DCN COL1A1 NA NA NA NA NA NA NA NA 0,9352688 NA

3 COL3A1 COL6A2 TAGLN NA NA NA NA NA NA NA 0,93491215 NA

4 COL3A1 COL1A1 TAGLN PAMR1 NA NA NA NA NA NA 0,93484612 NA

4 COL3A1 TAGLN COL6A1 PAMR1 NA NA NA NA NA NA 0,93432836 NA

5 COL3A1 COL6A2 TAGLN COL6A1 PAMR1 NA NA NA NA NA 0,93341743 NA

2 COL3A1 DCN NA NA NA NA NA NA NA NA 0,93285081 NA

4 COL6A2 COL1A1 TAGLN COL6A1 NA NA NA NA NA NA 0,93193611 NA

3 DCN COL1A1 PAMR1 NA NA NA NA NA NA NA 0,93151464 NA

4 C0L1A1 TAGLN COL6A1 PAMR1 NA NA NA NA NA NA 0,93132447 NA

3 DCN TAGLN GREM1 NA NA NA NA NA NA NA 0,9312344 NA

4 COL3A1 COL6A2 TAGLN PAMR1 NA NA NA NA NA NA 0,93080692 NA

3 DCN COL6A2 COL6A1 NA NA NA NA NA NA NA 0,93073444 NA

4 COL6A2 COL1A1 TAGLN PAMR1 NA NA NA NA NA NA 0,93066419 NA

3 COL6A2 COL1A1 TAGLN NA NA NA NA NA NA NA 0,93049878 NA

5 COL6A2 COL1A1 TAGLN COL6A1 PAMR1 NA NA NA NA NA 0,93000607 NA

2 DCN TAGLN NA NA NA NA NA NA NA NA 0,93000162 NA

4 COL3A1 COL1A1 GREM1 PAMR1 NA NA NA NA NA NA 0,92934086 NA

5 COL3A1 COL6A2 COL1A1 COL6A1 PAMR1 NA NA NA NA NA 0,92908899 NA

3 COL3A1 COL1A1 TAGLN NA NA NA NA NA NA NA 0,92899851 NA

4 COL3A1 COL1A1 COL6A1 PAMR1 NA NA NA NA NA NA 0,92805326 NA

3 COL1A1 G EM1 COL6A1 NA NA NA NA NA NA NA 0,92792757 NA

3 COL6A2 COL1A1 GREM1 NA NA NA NA NA NA NA 0,92784297 NA

4 DCN TAGLN GREM1 PAMR1 NA NA NA NA NA NA 0,92631663 NA

4 COL1A1 TAGLN GREM1 PAMR1 NA NA NA NA NA NA 0,92550187 NA

4 COL3A1 COL6A2 COL1A1 PAMR1 NA NA NA NA NA NA 0,92509867 NA

4 DCN TAGLN COL6A1 PAMR1 NA NA NA NA NA NA 0,92461277 NA

4 COL3A1 COL6A2 COL1A1 COL6A1 NA NA NA NA NA NA 0,92429785 NA

4 COL3A1 TAGLN GREM1 PAMR1 NA NA NA NA NA NA 0,9237134 NA

3 COL6A2 GREM1 COL6A1 NA NA NA NA NA NA NA 0,92307932 NA

2 COL3A1 COL6A1 NA NA NA NA NA NA NA NA 0,92259382 NA

3 COL6A2 TAGLN GREM1 NA NA NA NA NA NA NA 0,92243674 NA

3 COL3A1 COL1A1 COL6A1 NA NA NA NA NA NA NA 0,92222688 NA

3 DCN COL6A2 PAMR1 NA NA NA NA NA NA NA 0,92203838 NA

4 COL6A2 TAGLN GREM1 PAMR1 NA NA NA NA NA NA 0,92170291 NA

3 COL3A1 DCN PAMR1 NA NA NA NA NA NA NA 0,92099493 NA

4 COL6A2 GREM1 COL6A1 PAMR1 NA NA NA NA NA NA 0,92049732 NA

3 TAGLN G EM1 COL6A1 NA NA NA NA NA NA NA 0,91841561 NA

3 C0L3A1 TAGLN GREM1 NA NA NA NA NA NA NA 0,91824046 NA

2 DCN COL6A1 NA NA NA NA NA NA NA NA 0,91779458 NA

3 C0L1A1 TAGLN GREM1 NA NA NA NA NA NA NA 0,91704338 NA

2 COL3A1 COL6A2 NA NA NA NA NA NA NA NA 0,91641394 NA

2 COL3A1 TAGLN NA NA NA NA NA NA NA NA 0,9162866 NA

3 COL3A1 COL6A2 COL1A1 NA NA NA NA NA NA NA 0,91617706 NA

2 COL1A1 TAGLN NA NA NA NA NA NA NA NA 0,91482965 NA

3 COL3A1 COL1A1 GREM1 NA NA NA NA NA NA NA 0,91428844 NA

3 COL3A1 COL6A2 COL6A1 NA NA NA NA NA NA NA 0,91354505 NA

3 COL3A1 COL6A2 PAMR1 NA NA NA NA NA NA NA 0,912841 NA

3 COL1A1 TAGLN PAMR1 NA NA NA NA NA NA NA 0,91132601 NA

4 TAGLN GREM1 COL6A1 PAMR1 NA NA NA NA NA NA 0,91055151 NA

4 DCN COL6A2 COL6A1 PAMR1 NA NA NA NA NA NA 0,90922088 NA

4 COL3A1 COL6A2 COL6A1 PAMR1 NA NA NA NA NA NA 0,90802323 NA

3 COL3A1 TAGLN PAMR1 NA NA NA NA NA NA NA 0,90402113 NA

3 COL3A1 COL1A1 PAMR1 NA NA NA NA NA NA NA 0,90303513 NA

3 COL3A1 COL6A1 PAMR1 NA NA NA NA NA NA NA 0,90153196 NA

3 COL6A2 GREM1 PAMR1 NA NA NA NA NA NA NA 0,90116353 NA

3 COL3A1 GREM1 PAMR1 NA NA NA NA NA NA NA 0,89981241 NA

2 COL6A2 GREM1 NA NA NA NA NA NA NA NA 0,89847996 NA

3 COL6A2 COL1A1 PAMR1 NA NA NA NA NA NA NA 0,89821453 NA

2 DCN GREM1 NA NA NA NA NA NA NA NA 0,89738553 NA

2 COL6A2 TAGLN NA NA NA NA NA NA NA NA 0,89554505 NA

3 COL6A2 COL1A1 COL6A1 NA NA NA NA NA NA NA 0,89469611 NA

4 COL6A2 COL1A1 COL6A1 PAMR1 NA NA NA NA NA NA 0,89467184 NA

2 COL6A2 COL1A1 NA NA NA NA NA NA NA NA 0,89376263 NA

3 DCN GREM1 PAMR1 NA NA NA NA NA NA NA 0,89309876 NA

3 COL6A2 TAGLN COL6A1 NA NA NA NA NA NA NA 0,89243121 NA

3 C0L1A1 GREM1 PAMR1 NA NA NA NA NA NA NA 0,89116446 NA

3 DCN TAGLN PAMR1 NA NA NA NA NA NA NA 0,88976778 NA

2 COL3A1 COL1A1 NA NA NA NA NA NA NA NA 0,88969214 NA

2 COL3A1 GREM1 NA NA NA NA NA NA NA NA 0,88660876 NA

2 COL1A1 COL6A1 NA NA NA NA NA NA NA NA 0,8834657 NA

1 COL3A1 NA NA NA NA NA NA NA NA NA 0,87959538 NA

2 TAGLN COL6A1 NA NA NA NA NA NA NA NA 0,87782839 NA

3 COL1A1 COL6A1 PAMR1 NA NA NA NA NA NA NA 0,8777193 NA

1 DCN NA NA NA NA NA NA NA NA NA 0,87602404 NA

2 COL1A1 GREM1 NA NA NA NA NA NA NA NA 0,87369202 NA

4 COL6A2 TAGLN COL6A1 PAMR1 NA NA NA NA NA NA 0,87269023 NA

2 G EM1 COL6A1 NA NA NA NA NA NA NA NA 0,87049248 NA

3 COL6A2 TAGLN PAMR1 NA NA NA NA NA NA NA 0,86802175 NA

3 GREM1 COL6A1 PAMR1 NA NA NA NA NA NA NA 0,86166549 NA

3 DCN COL6A1 PAMR1 NA NA NA NA NA NA NA 0,86134462 NA

2 COL3A1 PAMR1 NA NA NA NA NA NA NA NA 0,85837164 NA

1 COL6A2 NA NA NA NA NA NA NA NA NA 0,84251237 NA

2 TAGLN GREM1 NA NA NA NA NA NA NA NA 0,84231571 NA

3 TAGLN GREM1 PAMR1 NA NA NA NA NA NA NA 0,84017605 NA

2 COL1A1 PAMR1 NA NA NA NA NA NA NA NA 0,83976809 NA

1 COL1A1 NA NA NA NA NA NA NA NA NA 0,83626927 NA

3 TAGLN COL6A1 PAMR1 NA NA NA NA NA NA NA 0,82231654 NA

2 COL6A2 COL6A1 NA NA NA NA NA NA NA NA 0,81599322 NA

1 TAGLN NA NA NA NA NA NA NA NA NA 0,80497058 NA

3 COL6A2 COL6A1 PAMR1 NA NA NA NA NA NA NA 0,78720417 NA

2 DCN PAMR1 NA NA NA NA NA NA NA NA 0,7860957 NA

2 COL6A2 PAMR1 NA NA NA NA NA NA NA NA 0,77993713 NA

2 GREM1 PAMR1 NA NA NA NA NA NA NA NA 0,72514134 NA

2 TAGLN PAMR1 NA NA NA NA NA NA NA NA 0,72116192 NA

1 G EM1 NA NA NA NA NA NA NA NA NA 0,71888174 NA

1 COL6A1 NA NA NA NA NA NA NA NA NA 0,6911634 NA

2 COL6A1 PAMR1 NA NA NA NA NA NA NA NA 0,58159652 NA

1 PAMR1 NA NA NA NA NA NA NA NA NA 0,08455272 NA

Combination of genes for identification of cells of monocytic origin

2 CSF1R FPR3 NA NA NA NA NA NA NA NA 0,87165335 0,989098

3 ADAP2 FPR3 PLA2G7 NA NA NA NA NA NA NA 0,79500676 0,9886500

3 CSF1R ADAP2 FPR3 NA NA NA NA NA NA NA 0,89320392 0,98853

4 CSF1R ADAP2 FPR3 PLA2G7 NA NA NA NA NA NA 0,88070275 0,9865886

2 FPR3 PLA2G7 NA NA NA NA NA NA NA NA 0,6978311 0,9833358

3 CSF1R FPR3 PLA2G7 NA NA NA NA NA NA NA 0,84348522 0,9828738

3 CSF1R FPR3 KYNU NA NA NA NA NA NA NA 0,85697068 0,9805074

5 CSF1R ADAP2 FPR3 PLA2G7 KYNU NA NA NA NA NA 0,87708908 0,9796659

2 CSF1R ADAP2 NA NA NA NA NA NA NA NA 0,86106378 0,9790929

4 CSF1R FPR3 PLA2G7 KYNU NA NA NA NA NA NA 0,83666996 0,9786913

4 CSF1R ADAP2 FPR3 KYNU NA NA NA NA NA NA 0,89137636 0,9773886

3 CSF1R ADAP2 PLA2G7 NA NA NA NA NA NA NA 0,89301648 0,9769443

3 FPR3 PLA2G7 KYNU NA NA NA NA NA NA NA 0,70257538 0,9756966

4 ADAP2 FPR3 PLA2G7 KYNU NA NA NA NA NA NA 0,79222991 0,9756206

2 ADAP2 PLA2G7 NA NA NA NA NA NA NA NA 0,76325543 0,9747496

1 CSF1R NA NA NA NA NA NA NA NA NA 0,80084571 0,9745176

5 CSF1R ADAP2 FPR3 TFEC PLA2G7 NA NA NA NA NA 0,90713273 0,9698332

4 CSF1R ADAP2 PLA2G7 KYNU NA NA NA NA NA NA 0,88572286 0,9691905

2 CSF1R PLA2G7 NA NA NA NA NA NA NA NA 0,838643 0,9690311

4 CSF1R FPR3 TFEC PLA2G7 NA NA NA NA NA NA 0,88163015 0,9670523

3 CSF1R PLA2G7 KYNU NA NA NA NA NA NA NA 0,82363724 0,9649058

6 CSF1 ADAP2 FPR3 TFEC PLA2G7 KYNU NA NA NA NA 0,9047556 0,9641737

5 CSF1R ADAP2 RASSF4 FPR3 PLA2G7 NA NA NA NA NA 0,96346089 0,9640594

3 CSF1R ADAP2 KYNU NA NA NA NA NA NA NA 0,87490749 0,963696

5 CSF1R FPR3 TFEC PLA2G7 KYNU NA NA NA NA NA 0,87627421 0,9622605

4 CSF1R ADAP2 FPR3 TFEC NA NA NA NA NA NA 0,91862941 0,9613707

4 CSF1R ADAP2 RASSF4 FPR3 NA NA NA NA NA NA 0,96106023 0,961046

2 CSF1R KYNU NA NA NA NA NA NA NA NA 0,8000538 0,9609008

4 CSF1R ADAP2 TFEC PLA2G7 NA NA NA NA NA NA 0,9249639 0,9606376

6 CSF1R ADAP2 RASSF4 FPR3 PLA2G7 KYNU NA NA NA NA 0,96360464 0,9605852

4 ADAP2 FPR3 TFEC PLA2G7 NA NA NA NA NA NA 0,8415891 0,9595288

3 ADAP2 PLA2G7 KYNU NA NA NA NA NA NA NA 0,75753273 0,9587621

3 CSF1R FPR3 TFEC NA NA NA NA NA NA NA 0,90463501 0,9585647

1 PLA2G7 NA NA NA NA NA NA NA NA NA 0,5376277 0,9566187

5 CSF1R ADAP2 RASSF4 FPR3 KYNU NA NA NA NA NA 0,96905506 0,9557350

4 CSF1R RASSF4 FPR3 PLA2G7 NA NA NA NA NA NA 0,95495888 0,9553904

3 CSF1R TFEC PLA2G7 NA NA NA NA NA NA NA 0,89332119 0,9551727

6 CSF1R ADAP2 RASSF4 FPR3 TFEC PLA2G7 NA NA NA NA 0,9710615 0,9547654

5 CSF1R ADAP2 TFEC PLA2G7 KYNU NA NA NA NA NA 0,92097386 0,9546986

5 CSF1R ADAP2 FPR3 TFEC KYNU NA NA NA NA NA 0,91925853 0,9546309

5 CSF1R RASSF4 FPR3 PLA2G7 KYNU NA NA NA NA NA 0,9517327 0,9546070

3 FPR3 TFEC PLA2G7 NA NA NA NA NA NA NA 0,77676194 0,9539160

4 ADAP2 RASSF4 FPR3 PLA2G7 NA NA NA NA NA NA 0,93686931 0,9527902

4 CSF1R FPR3 TFEC KYNU NA NA NA NA NA NA 0,89760987 0,9525603

5 ADAP2 FPR3 TFEC PLA2G7 KYNU NA NA NA NA NA 0,83886295 0,9521677

4 CSF1R ADAP2 RASSF4 PLA2G7 NA NA NA NA NA NA 0,96460973 0,9515668

7 CSF1R ADAP2 RASSF4 FPR3 TFEC PLA2G7 KYNU NA NA NA 0,97253139 0,9515335

4 CSF1R TFEC PLA2G7 KYNU NA NA NA NA NA NA 0,88286922 0,9505079

2 PLA2G7 KYNU NA NA NA NA NA NA NA NA 0,57778973 0,9498990

3 CSF1R ADAP2 TFEC NA NA NA NA NA NA NA 0,90833099 0,9497240

3 ADAP2 FPR3 KYNU NA NA NA NA NA NA NA 0,8167454 0,9496503

5 ADAP2 RASSF4 FPR3 PLA2G7 KYNU NA NA NA NA NA 0,93249315 0,9492038

3 CSF1 RASSF4 FPR3 NA NA NA NA NA NA NA 0,95895418 0,9491631

5 CSF1R ADAP2 RASSF4 PLA2G7 KYNU NA NA NA NA NA 0,970852 0,9489921

2 FPR3 KYNU NA NA NA NA NA NA NA NA 0,70823929 0,948964

5 CSF1R RASSF4 FPR3 TFEC PLA2G7 NA NA NA NA NA 0,96418404 0,9484367

4 CSF1R RASSF4 FPR3 KYNU NA NA NA NA NA NA 0,96332578 0,9481567

4 FPR3 TFEC PLA2G7 KYNU NA NA NA NA NA NA 0,77612661 0,9481520

5 CSF1R ADAP2 RASSF4 FPR3 TFEC NA NA NA NA NA 0,96886588 0,947572

2 ADAP2 FPR3 NA NA NA NA NA NA NA NA 0,83502288 0,9468291

6 CSF1R RASSF4 FPR3 TFEC PLA2G7 KYNU NA NA NA NA 0,96339854 0,9465859

3 ADAP2 TFEC PLA2G7 NA NA NA NA NA NA NA 0,83683401 0,9453435

5 CSF1R ADAP2 RASSF4 TFEC PLA2G7 NA NA NA NA NA 0,97488781 0,9442126

3 CSF1R ADAP2 RASSF4 NA NA NA NA NA NA NA 0,91396178 0,9437515

6 CSF1R ADAP2 RASSF4 FPR3 TFEC KYNU NA NA NA NA 0,97712758 0,943610

2 CSF1R TFEC NA NA NA NA NA NA NA NA 0,88053612 0,9423872

4 CSF1R ADAP2 TFEC KYNU NA NA NA NA NA NA 0,9200644 0,9421010

5 ADAP2 RASSF4 FPR3 TFEC PLA2G7 NA NA NA NA NA 0,94670945 0,941612

6 CSF1R ADAP2 RASSF4 TFEC PLA2G7 KYNU NA NA NA NA 0,9816282 0,941577

4 CSF1R ADAP2 RASSF4 KYNU NA NA NA NA NA NA 0,94436447 0,9400986

4 CSF1R RASSF4 PLA2G7 KYNU NA NA NA NA NA NA 0,9525739 0,9400822

4 CSF1R RASSF4 FPR3 TFEC NA NA NA NA NA NA 0,96626573 0,9390601

3 CSF1R RASSF4 PLA2G7 NA NA NA NA NA NA NA 0,94869765 0,9389687

6 ADAP2 RASSF4 FPR3 TFEC PLA2G7 KYNU NA NA NA NA 0,9453955 0,9385506

4 RASSF4 FPR3 PLA2G7 KYNU NA NA NA NA NA NA 0,90116119 0,9380895

4 ADAP2 TFEC PLA2G7 KYNU NA NA NA NA NA NA 0,83126553 0,9377464

1 ADAP2 NA NA NA NA NA NA NA NA NA 0,79466903 0,937561

5 CSF1R RASSF4 FPR3 TFEC KYNU NA NA NA NA NA 0,97258664 0,93711

3 CSF1R TFEC KYNU NA NA NA NA NA NA NA 0,88354615 0,9360555

4 CSF1 RASSF4 TFEC PLA2G7 NA NA NA NA NA NA 0,96335243 0,9353387

3 ASSF4 FPR3 PLA2G7 NA NA NA NA NA NA NA 0,90922117 0,9349525

5 CSF1R RASSF4 TFEC PLA2G7 KYNU NA NA NA NA NA 0,9687047 0,9346008

3 ADAP2 RASSF4 FPR3 NA NA NA NA NA NA NA 0,95738414 0,9342904

4 CSF1R ADAP2 RASSF4 TFEC NA NA NA NA NA NA 0,93838817 0,9336311

2 TFEC PLA2G7 NA NA NA NA NA NA NA NA 0,71513867 0,9330200

3 ADAP2 RASSF4 PLA2G7 NA NA NA NA NA NA NA 0,93214072 0,9323604

4 ADAP2 RASSF4 FPR3 KYNU NA NA NA NA NA NA 0,95629549 0,9319151

4 ADAP2 RASSF4 PLA2G7 KYNU NA NA NA NA NA NA 0,9329197 0,9314473

5 CSF1R ADAP2 RASSF4 TFEC KYNU NA NA NA NA NA 0,96280022 0,9307147

4 RASSF4 FPR3 TFEC PLA2G7 NA NA NA NA NA NA 0,9251673 0,9300139

5 RASSF4 FPR3 TFEC PLA2G7 KYNU NA NA NA NA NA 0,92158396 0,9299586

3 TFEC PLA2G7 KYNU NA NA NA NA NA NA NA 0,72158999 0,9285941

3 CSF1R RASSF4 KYNU NA NA NA NA NA NA NA 0,91766392 0,9271964

4 ADAP2 RASSF4 TFEC PLA2G7 NA NA NA NA NA NA 0,94572755 0,9258242

5 ADAP2 RASSF4 TFEC PLA2G7 KYNU NA NA NA NA NA 0,94972994 0,9242918

2 CSF1R RASSF4 NA NA NA NA NA NA NA NA 0,87870297 0,9239383

4 CSF1R RASSF4 TFEC KYNU NA NA NA NA NA NA 0,94583934 0,920885

3 CSF1R RASSF4 TFEC NA NA NA NA NA NA NA 0,91642923 0,9206616

4 ADAP2 RASSF4 FPR3 TFEC NA NA NA NA NA NA 0,95907943 0,9206271

4 ADAP2 FPR3 TFEC KYNU NA NA NA NA NA NA 0,86391711 0,9203909

5 ADAP2 RASSF4 FPR3 TFEC KYNU NA NA NA NA NA 0,96275672 0,9194295

3 ADAP2 FPR3 TFEC NA NA NA NA NA NA NA 0,87188675 0,9183231

2 ADAP2 KYNU NA NA NA NA NA NA NA NA 0,74723243 0,9171372

3 RASSF4 PLA2G7 KYNU NA NA NA NA NA NA NA 0,87690005 0,9138950

4 RASSF4 TFEC PLA2G7 KYNU NA NA NA NA NA NA 0,91105188 0,9118143

3 RASSF4 FPR3 KYNU NA NA NA NA NA NA NA 0,93497686 0,9109756

3 RASSF4 TFEC PLA2G7 NA NA NA NA NA NA NA 0,90672296 0,9088405

3 FPR3 TFEC KYNU NA NA NA NA NA NA NA 0,79807777 0,9061763

4 ASSF4 FPR3 TFEC KYNU NA NA NA NA NA NA 0,94544605 0,9045239

2 ASSF4 PLA2G7 NA NA NA NA NA NA NA NA 0,8756298 0,9044325

3 ADAP2 RASSF4 KYNU NA NA NA NA NA NA NA 0,91840233 0,9032157

4 ADAP2 RASSF4 TFEC KYNU NA NA NA NA NA NA 0,93984345 0,8985746

3 ASSF4 FPR3 TFEC NA NA NA NA NA NA NA 0,94602168 0,8984237

2 ADAP2 RASSF4 NA NA NA NA NA NA NA NA 0,88631608 0,8973047

3 ADAP2 TFEC KYNU NA NA NA NA NA NA NA 0,84241181 0,8960949

3 ADAP2 RASSF4 TFEC NA NA NA NA NA NA NA 0,91358694 0,8959969

2 ASSF4 FPR3 NA NA NA NA NA NA NA NA 0,94675446 0,8925746

2 ADAP2 TFEC NA NA NA NA NA NA NA NA 0,84831731 0,8922839

2 FPR3 TFEC NA NA NA NA NA NA NA NA 0,81415546 0,8874500

3 RASSF4 TFEC KYNU NA NA NA NA NA NA NA 0,89111598 0,875738

1 KYNU NA NA NA NA NA NA NA NA NA 0,38453106 0,8754236

2 TFEC KYNU NA NA NA NA NA NA NA NA 0,68382499 0,8670998

2 RASSF4 KYNU NA NA NA NA NA NA NA NA 0,84031596 0,8658694

2 RASSF4 TFEC NA NA NA NA NA NA NA NA 0,85405471 0,8609163

1 TFEC NA NA NA NA NA NA NA NA NA 0,67583743 0,8333339

1 RASSF4 NA NA NA NA NA NA NA NA NA 0,78691117 0,8207336

1 FPR3 NA NA NA NA NA NA NA NA NA 0,7399244 0,7431714

Combination of genes for identification of myeloid dendritic cells

6 CD1E CLECIOA CLIC2 CD1A WFDC21P CD1B NA NA NA NA 0,99492686 NA

5 CD1E CLECIOA CLIC2 CD1A WFDC21P NA NA NA NA NA 0,98265982 NA

5 CD1E CLIC2 CD1A WFDC21P CD1B NA NA NA NA NA 0,97491629 NA

5 CLECIOA CLIC2 CD1A WFDC21P CD1B NA NA NA NA NA 0,97073779 NA

5 CD1E CLECIOA CLIC2 WFDC21P CD1B NA NA NA NA NA 0,96818309 NA

4 CD1E CLIC2 CD1A WFDC21P NA NA NA NA NA NA 0,96518248 NA

5 CD1E CLECIOA CLIC2 CD1A CD1B NA NA NA NA NA 0,96489986 NA

4 CD1E CLIC2 WFDC21P CD1B NA NA NA NA NA NA 0,95741774 NA

4 CLECIOA CLIC2 CD1A WFDC21P NA NA NA NA NA NA 0,95564947 NA

4 CD1E CLECIOA CD1A WFDC21P NA NA NA NA NA NA 0,94998556 NA

4 CD1E CLECIOA CLIC2 CD1A NA NA NA NA NA NA 0,94950879 NA

4 CD1E CLECIOA WFDC21P CD1B NA NA NA NA NA NA 0,9426883 NA

5 CD1E CLECIOA CD1A WFDC21P CD1B NA NA NA NA NA 0,94266831 NA

4 CLECIOA CLIC2 CD1A CD1B NA NA NA NA NA NA 0,94104583 NA

4 CD1E CLIC2 CD1A CD1B NA NA NA NA NA NA 0,93610342 NA

4 CD1E CLECIOA CLIC2 WFDC21P NA NA NA NA NA NA 0,92919889 NA

4 CLECIOA CLIC2 WFDC21P CD1B NA NA NA NA NA NA 0,92647595 NA

3 CD1E CLECIOA CD1A NA NA NA NA NA NA NA 0,92383479 NA

3 CD1E CLIC2 CD1A NA NA NA NA NA NA NA 0,92375404 NA

3 CLECIOA CLIC2 CD1A NA NA NA NA NA NA NA 0,92292778 NA

4 CD1E CLECIOA CLIC2 CD1B NA NA NA NA NA NA 0,92116461 NA

4 CLIC2 CD1A WFDC21P CD1B NA NA NA NA NA NA 0,92115525 NA

3 CD1E CLECIOA WFDC21P NA NA NA NA NA NA NA 0,91684989 NA

3 CD1E CLIC2 WFDC21P NA NA NA NA NA NA NA 0,9089283 NA

4 CD1E CLECIOA CD1A CD1B NA NA NA NA NA NA 0,90834445 NA

3 CLIC2 CD1A WFDC21P NA NA NA NA NA NA NA 0,90690228 NA

3 CD1E CLECIOA CD1B NA NA NA NA NA NA NA 0,9006761 NA

3 CD1E CLIC2 CD1B NA NA NA NA NA NA NA 0,89761333 NA

3 CLECIOA CD1A WFDC21P NA NA NA NA NA NA NA 0,89134337 NA

2 CLECIOA CD1A NA NA NA NA NA NA NA NA 0,88554522 NA

3 CD1E WFDC21P CD1B NA NA NA NA NA NA NA 0,88550803 NA

3 CD1E CD1A WFDC21P NA NA NA NA NA NA NA 0,88095184 NA

4 CLECIOA CD1A WFDC21P CD1B NA NA NA NA NA NA 0,87802773 NA

3 CLIC2 WFDC21P CD1B NA NA NA NA NA NA NA 0,87697979 NA

3 CLIC2 CD1A CD1B NA NA NA NA NA NA NA 0,87303731 NA

3 CD1E CLECIOA CLIC2 NA NA NA NA NA NA NA 0,86992304 NA

3 CLECIOA CLIC2 WFDC21P NA NA NA NA NA NA NA 0,86947691 NA

3 CLECIOA CLIC2 CD1B NA NA NA NA NA NA NA 0,86831099 NA

2 CD1E CLECIOA NA NA NA NA NA NA NA NA 0,86640606 NA

4 CD1E CD1A WFDC21P CD1B NA NA NA NA NA NA 0,86585424 NA

2 CD1E WFDC21P NA NA NA NA NA NA NA NA 0,86094161 NA

3 CLECIOA WFDC21P CD1B NA NA NA NA NA NA NA 0,86072267 NA

2 CLIC2 CD1A NA NA NA NA NA NA NA NA 0,85709565 NA

3 CLECIOA CD1A CD1B NA NA NA NA NA NA NA 0,83811977 NA

2 CD1E CD1A NA NA NA NA NA NA NA NA 0,83091078 NA

2 CD1E CLIC2 NA NA NA NA NA NA NA NA 0,82851032 NA

2 CD1E CD1B NA NA NA NA NA NA NA NA 0,82105106 NA

2 CLECIOA CD1B NA NA NA NA NA NA NA NA 0,8187688 NA

2 CLECIOA WFDC21P NA NA NA NA NA NA NA NA 0,81583924 NA

1 CD1E NA NA NA NA NA NA NA NA NA 0,80113399 NA

3 CD1E CD1A CD1B NA NA NA NA NA NA NA 0,79950859 NA

2 CLIC2 WFDC21P NA NA NA NA NA NA NA NA 0,79670845 NA

2 CLECIOA CLIC2 NA NA NA NA NA NA NA NA 0,78815671 NA

2 CLIC2 CD1B NA NA NA NA NA NA NA NA 0,78611242 NA

1 CLECIOA NA NA NA NA NA NA NA NA NA 0,76505013 NA

2 CD1A WFDC21P NA NA NA NA NA NA NA NA 0,71209564 NA

3 CD1A WFDC21P CD1B NA NA NA NA NA NA NA 0,70913654 NA

1 CLIC2 NA NA NA NA NA NA NA NA NA 0,65793665 NA

2 WFDC21P CD1B NA NA NA NA NA NA NA NA 0,65507291 NA

1 CD1A NA NA NA NA NA NA NA NA NA 0,58904399 NA

2 CD1A CD1B NA NA NA NA NA NA NA NA 0,57000304 NA

1 WFDC21P NA NA NA NA NA NA NA NA NA 0,56583254 NA

1 CD1B NA NA NA NA NA NA NA NA NA 0,41093552 NA

Combination of genes for identification of cells of neutrophils

2 VNN3 CYP4F3 NA NA NA NA NA NA NA NA 0,49562347 0,9946419

3 NA VNN3 CYP4F3 NA NA NA NA NA NA NA 0,70025625 0,9931625

1 VNN3 NA NA NA NA NA NA NA NA NA 0,47602408 0,9930948

4 HAL VNN3 CYP4F3 CXCR1 NA NA NA NA NA NA 0,59500868 0,992637

3 FCG 3B VNN3 CYP4F3 NA NA NA NA NA NA NA 0,66672387 0,9924305

5 NA HAL VNN3 CYP4F3 CXCR1 NA NA NA NA NA 0,74300917 0,9923608

2 NA VNN3 NA NA NA NA NA NA NA NA 0,75157864 0,9920291

3 VNN3 CYP4F3 CXCR1 NA NA NA NA NA NA NA 0,52633156 0,9919357

4 NA HAL VNN3 CYP4F3 NA NA NA NA NA NA 0,72847342 0,9918959

4 NA FCGR3B VNN3 CYP4F3 NA NA NA NA NA NA 0,81270778 0,9918708

1 CYP4F3 NA NA NA NA NA NA NA NA NA 0,41264532 0,9918655

3 CXC 2 VNN3 CYP4F3 NA NA NA NA NA NA NA 0,63309894 0,9916884

3 HAL CYP4F3 CXCR1 NA NA NA NA NA NA NA 0,56769155 0,9916731

4 NA HAL CYP4F3 CXCR1 NA NA NA NA NA NA 0,73482751 0,9915968

4 NA VNN3 CYP4F3 CXCR1 NA NA NA NA NA NA 0,71735678 0,9915795

5 FCGR3B HAL VNN3 CYP4F3 CXCR1 NA NA NA NA NA 0,71496494 0,99156

6 NA FCGR3B HAL VNN3 CYP4F3 CXCR1 NA NA NA NA 0,83128742 0,9915184

3 KCNJ15 VNN3 CYP4F3 NA NA NA NA NA NA NA 0,82329073 0,9914909

2 NA CYP4F3 NA NA NA NA NA NA NA NA 0,65361118 0,991365

3 HAL VNN3 CYP4F3 NA NA NA NA NA NA NA 0,57306049 0,9913374

5 CXC 2 HAL VNN3 CYP4F3 CXCR1 NA NA NA NA NA 0,68697221 0,9913109

4 CXCR2 NA VNN3 CYP4F3 NA NA NA NA NA NA 0,78924075 0,9912775

6 CXCR2 NA HAL VNN3 CYP4F3 CXCR1 NA NA NA NA 0,80909562 0,9912577

4 FCGR3B VNN3 CYP4F3 CXCR1 NA NA NA NA NA NA 0,68005631 0,9911572

5 KCNJ15 HAL VNN3 CYP4F3 CXCR1 NA NA NA NA NA 0,84864837 0,9911022

5 CXCR2 NA HAL VNN3 CYP4F3 NA NA NA NA NA 0,8007367 0,9911016

4 KCNJ15 NA VNN3 CYP4F3 NA NA NA NA NA NA 0,84761446 0,9910911

6 KCNJ15 NA HAL VNN3 CYP4F3 CXCR1 NA NA NA NA 0,88426252 0,9910653

5 NA FCGR3B HAL VNN3 CYP4F3 NA NA NA NA NA 0,8248917 0,9909843

5 NA FCGR3B VNN3 CYP4F3 CXCR1 NA NA NA NA NA 0,81796651 0,9909842

3 NA HAL CYP4F3 NA NA NA NA NA NA NA 0,71590437 0,9909045

4 KCNJ15 VNN3 CYP4F3 CXCR1 NA NA NA NA NA NA 0,83445705 0,9908114

4 CXC 2 HAL VNN3 CYP4F3 NA NA NA NA NA NA 0,67280044 0,9908010

5 NA FCGR3B HAL CYP4F3 CXCR1 NA NA NA NA NA 0,83124021 0,9906483

5 KCNJ15 NA VNN3 CYP4F3 CXCR1 NA NA NA NA NA 0,85759418 0,9905966

7 CXCR2 NA FCGR3B HAL VNN3 CYP4F3 CXCR1 NA NA NA 0,85597731 0,990543

7 KCNJ15 NA FCGR3B HAL VNN3 CYP4F3 CXCR1 NA NA NA 0,92577474 0,9904626

4 NA HAL VNN3 CXCR1 NA NA NA NA NA NA 0,79656462 0,9904542

4 FCGR3B HAL CYP4F3 CXCR1 NA NA NA NA NA NA 0,70420012 0,9904281

6 CXC 2 FCGR3B HAL VNN3 CYP4F3 CXCR1 NA NA NA NA 0,75853108 0,9904241

3 NA FCGR3B VNN3 NA NA NA NA NA NA NA 0,81676382 0,990418

4 FCGR3B HAL VNN3 CYP4F3 NA NA NA NA NA NA 0,70318126 0,9904007

3 NA VNN3 CXCR1 NA NA NA NA NA NA NA 0,77185084 0,9903992

5 KCNJ15 NA HAL VNN3 CYP4F3 NA NA NA NA NA 0,87588681 0,9903730

7 KCNJ15 CXCR2 NA HAL VNN3 CYP4F3 CXCR1 NA NA NA 0,91615468 0,9903708

6 KCNJ15 FCGR3B HAL VNN3 CYP4F3 CXCR1 NA NA NA NA 0,896285 0,9903674

4 KCNJ15 FCGR3B VNN3 CYP4F3 NA NA NA NA NA NA 0,87580527 0,990350

6 KCNJ15 CXCR2 HAL VNN3 CYP4F3 CXCR1 NA NA NA NA 0,88666836 0,9903288

5 CXCR2 NA FCGR3B VNN3 CYP4F3 NA NA NA NA NA 0,83635652 0,9903117

5 KCNJ15 NA FCGR3B VNN3 CYP4F3 NA NA NA NA NA 0,89715372 0,9903086

5 CXCR2 NA HAL CYP4F3 CXCR1 NA NA NA NA NA 0,81032241 0,9902946

5 KCNJ15 NA HAL CYP4F3 CXCR1 NA NA NA NA NA 0,87577919 0,9902696

4 CXCR2 FCGR3B VNN3 CYP4F3 NA NA NA NA NA NA 0,71979062 0,9902576

6 CXCR2 NA FCGR3B HAL VNN3 CYP4F3 NA NA NA NA 0,85224093 0,9902401

4 KCNJ15 CXCR2 VNN3 CYP4F3 NA NA NA NA NA NA 0,86929391 0,9902240

5 KCNJ15 FCGR3B VNN3 CYP4F3 CXCR1 NA NA NA NA NA 0,8804988 0,9901545

5 CXC 2 NA VNN3 CYP4F3 CXCR1 NA NA NA NA NA 0,79690353 0,9901340

4 KCNJ15 HAL CYP4F3 CXCR1 NA NA NA NA NA NA 0,84424966 0,9901310

3 NA FCGR3B CYP4F3 NA NA NA NA NA NA NA 0,78661387 0,9901

2 VNN3 CXCR1 NA NA NA NA NA NA NA NA 0,53200447 0,9901153

5 KCNJ15 CXCR2 NA VNN3 CYP4F3 NA NA NA NA NA 0,88831792 0,9901141

6 KCNJ15 NA FCGR3B VNN3 CYP4F3 CXCR1 NA NA NA NA 0,90190197 0,990105

4 CXC 2 HAL CYP4F3 CXCR1 NA NA NA NA NA NA 0,67603087 0,9900642

4 CXC 2 NA HAL CYP4F3 NA NA NA NA NA NA 0,79951842 0,9900283

2 FCGR3B VNN3 NA NA NA NA NA NA NA NA 0,64948592 0,9900022

4 CXCR2 VNN3 CYP4F3 CXCR1 NA NA NA NA NA NA 0,64989844 0,9899941

6 KCNJ15 CXCR2 NA HAL VNN3 CYP4F3 NA NA NA NA 0,91098641 0,9899893

4 NA FCGR3B VNN3 CXCR1 NA NA NA NA NA NA 0,82245978 0,9898950

4 NA FCGR3B HAL CYP4F3 NA NA NA NA NA NA 0,82272561 0,9898594

8 KCNJ15 CXCR2 NA FCGR3B HAL VNN3 CYP4F3 CXCR1 NA NA 0,93502717 0,9898206

4 KCNJ15 HAL VNN3 CYP4F3 NA NA NA NA NA NA 0,83859041 0,9898096

5 NA FCGR3B HAL VNN3 CXCR1 NA NA NA NA NA 0,86735977 0,9898045

6 KCNJ15 NA FCGR3B HAL VNN3 CYP4F3 NA NA NA NA 0,92157256 0,9897814

5 CXCR2 FCGR3B HAL VNN3 CYP4F3 NA NA NA NA NA 0,75084097 0,9897782

2 FCGR3B CYP4F3 NA NA NA NA NA NA NA NA 0,62303304 0,9897480

3 FCGR3B VNN3 CXCR1 NA NA NA NA NA NA NA 0,66677854 0,9896832

6 CXCR2 NA FCGR3B VNN3 CYP4F3 CXCR1 NA NA NA NA 0,83908826 0,9896729

7 KCNJ15 CXCR2 FCGR3B HAL VNN3 CYP4F3 CXCR1 NA NA NA 0,90688084 0,989663

6 KCNJ15 CXCR2 NA VNN3 CYP4F3 CXCR1 NA NA NA NA 0,89412636 0,9896496

5 KCNJ15 CXCR2 HAL VNN3 CYP4F3 NA NA NA NA NA 0,88069831 0,9896427

6 KCNJ15 NA FCGR3B HAL CYP4F3 CXCR1 NA NA NA NA 0,91981747 0,9896208

5 KCNJ15 CXCR2 VNN3 CYP4F3 CXCR1 NA NA NA NA NA 0,87507039 0,9896082

3 CXCR2 NA VNN3 NA NA NA NA NA NA NA 0,8482567 0,9896012

5 CXCR2 NA HAL VNN3 CXCR1 NA NA NA NA NA 0,8689723 0,9895713

6 CXC 2 NA FCGR3B HAL CYP4F3 CXCR1 NA NA NA NA 0,85645437 0,9895427

3 KCNJ15 NA CYP4F3 NA NA NA NA NA NA NA 0,81187958 0,989537

6 KCNJ15 CXCR2 NA HAL CYP4F3 CXCR1 NA NA NA NA 0,91172316 0,9895020

5 CXC 2 FCGR3B VNN3 CYP4F3 CXCR1 NA NA NA NA NA 0,72785047 0,9894518

6 KCNJ15 CXCR2 NA FCGR3B VNN3 CYP4F3 NA NA NA NA 0,90791548 0,9894268

2 KCNJ15 CYP4F3 NA NA NA NA NA NA NA NA 0,78744764 0,9893920

7 KCNJ15 CXCR2 NA FCGR3B HAL VNN3 CYP4F3 NA NA NA 0,93234305 0,9893771

2 HAL CYP4F3 NA NA NA NA NA NA NA NA 0,53944218 0,9893349

5 KCNJ15 FCGR3B HAL CYP4F3 CXCR1 NA NA NA NA NA 0,89353139 0,9893241

4 KCNJ15 NA HAL CYP4F3 NA NA NA NA NA NA 0,86471169 0,9893202

3 NA CYP4F3 CXCR1 NA NA NA NA NA NA NA 0,67935574 0,9893181

5 KCNJ15 CXCR2 FCGR3B VNN3 CYP4F3 NA NA NA NA NA 0,88467673 0,9892751

5 KCNJ15 CXCR2 HAL CYP4F3 CXCR1 NA NA NA NA NA 0,88647978 0,9892720

7 KCNJ15 CXCR2 NA FCGR3B VNN3 CYP4F3 CXCR1 NA NA NA 0,91093672 0,9892245

5 KCNJ15 FCGR3B HAL VNN3 CYP4F3 NA NA NA NA NA 0,89143032 0,9892104

3 HAL VNN3 CXCR1 NA NA NA NA NA NA NA 0,60203253 0,9892082

3 CXC 2 NA CYP4F3 NA NA NA NA NA NA NA 0,76489412 0,9891982

5 KCNJ15 NA HAL VNN3 CXCR1 NA NA NA NA NA 0,88371283 0,9891723

4 KCNJ15 NA VNN3 CXCR1 NA NA NA NA NA NA 0,80756758 0,9891686

3 CXC 2 HAL CYP4F3 NA NA NA NA NA NA NA 0,65804633 0,9891602

4 NA FCGR3B CYP4F3 CXCR1 NA NA NA NA NA NA 0,79616979 0,9891320

5 CXCR2 FCGR3B HAL CYP4F3 CXCR1 NA NA NA NA NA 0,75195396 0,9891289

5 CXCR2 NA FCGR3B HAL CYP4F3 NA NA NA NA NA 0,85134807 0,9890727

6 KCNJ15 CXCR2 FCGR3B VNN3 CYP4F3 CXCR1 NA NA NA NA 0,88763436 0,9890723

4 KCNJ15 NA CYP4F3 CXCR1 NA NA NA NA NA NA 0,82629856 0,9890121

5 KCNJ15 CXCR2 NA HAL CYP4F3 NA NA NA NA NA 0,90466321 0,9889792

2 CXCR2 VNN3 NA NA NA NA NA NA NA NA 0,69598594 0,9889731

6 CXCR2 NA FCGR3B HAL VNN3 CXCR1 NA NA NA NA 0,87757073 0,9889486

6 KCNJ15 CXCR2 FCGR3B HAL VNN3 CYP4F3 NA NA NA NA 0,9037816 0,9889373

7 KCNJ15 CXCR2 NA FCGR3B HAL CYP4F3 CXCR1 NA NA NA 0,93008186 0,9889294

3 NA HAL CXCR1 NA NA NA NA NA NA NA 0,8028427 0,9889043

3 KCNJ15 VNN3 CXCR1 NA NA NA NA NA NA NA 0,83390061 0,9889011

4 FCG 3B HAL VNN3 CXCR1 NA NA NA NA NA NA 0,73444257 0,9888253

3 KCNJ15 NA VNN3 NA NA NA NA NA NA NA 0,7893318 0,9888116

4 KCNJ15 NA FCGR3B CYP4F3 NA NA NA NA NA NA 0,87020617 0,9888094

1 NA NA NA NA NA NA NA NA NA NA 0,61632959 0,9887987

5 KCNJ15 NA FCGR3B VNN3 CXCR1 NA NA NA NA NA 0,85293536 0,9887882

6 KCNJ15 NA FCGR3B HAL VNN3 CXCR1 NA NA NA NA 0,9174336 0,9887581

6 KCNJ15 CXCR2 NA HAL VNN3 CXCR1 NA NA NA NA 0,91961573 0,9887534

4 CXC 2 HAL VNN3 CXCR1 NA NA NA NA NA NA 0,72938377 0,9887081

5 KCNJ15 NA FCGR3B HAL CYP4F3 NA NA NA NA NA 0,9138491 0,9886995

5 KCNJ15 NA FCGR3B CYP4F3 CXCR1 NA NA NA NA NA 0,87794761 0,9886805

3 KCNJ15 CYP4F3 CXCR1 NA NA NA NA NA NA NA 0,804617 0,9886795

6 KCNJ15 CXCR2 FCGR3B HAL CYP4F3 CXCR1 NA NA NA NA 0,90423346 0,9885717

4 CXC 2 NA VNN3 CXCR1 NA NA NA NA NA NA 0,85046836 0,988563

4 KCNJ15 CXCR2 NA CYP4F3 NA NA NA NA NA NA 0,86231446 0,9885389

4 CXC 2 NA FCGR3B VNN3 NA NA NA NA NA NA 0,82249887 0,9885204

3 FCGR3B HAL CYP4F3 NA NA NA NA NA NA NA 0,68914121 0,9885080

4 KCNJ15 FCGR3B VNN3 CXCR1 NA NA NA NA NA NA 0,85263094 0,9884296

3 FCGR3B CYP4F3 CXCR1 NA NA NA NA NA NA NA 0,64274473 0,988424

5 NA VNN3 CYP4F3 CXCR1 STEAP4 NA NA NA NA NA 0,79708393 0,9884124

2 CXCR2 CYP4F3 NA NA NA NA NA NA NA NA 0,5880959 0,9883912

4 CXCR2 NA FCGR3B CYP4F3 NA NA NA NA NA NA 0,81616063 0,9883877

6 KCNJ15 CXCR2 NA FCGR3B HAL CYP4F3 NA NA NA NA 0,92608069 0,9883288

3 KCNJ15 FCGR3B CYP4F3 NA NA NA NA NA NA NA 0,84941405 0,9883061

4 KCNJ15 FCGR3B CYP4F3 CXCR1 NA NA NA NA NA NA 0,85772866 0,9883017

7 KCNJ15 CXCR2 NA FCGR3B HAL VNN3 CXCR1 NA NA NA 0,92508265 0,988299

4 NA FCGR3B HAL CXCR1 NA NA NA NA NA NA 0,86731865 0,9882909

4 KCNJ15 NA FCGR3B VNN3 NA NA NA NA NA NA 0,84297122 0,9882789

4 KCNJ15 CXCR2 HAL CYP4F3 NA NA NA NA NA NA 0,87841599 0,9882758

4 NA VNN3 CYP4F3 STEAP4 NA NA NA NA NA NA 0,78002779 0,9882503

4 KCNJ15 HAL VNN3 CXCR1 NA NA NA NA NA NA 0,88593951 0,9882441

5 CXC 2 NA FCGR3B VNN3 CXCR1 NA NA NA NA NA 0,82653812 0,9882327

6 NA FCGR3B VNN3 CYP4F3 CXCR1 STEAP4 NA NA NA NA 0,86950965 0,988215

4 KCNJ15 CXCR2 NA VNN3 NA NA NA NA NA NA 0,84677138 0,9882036

5 KCNJ15 CXCR2 NA VNN3 CXCR1 NA NA NA NA NA 0,8578191 0,9882028

3 KCNJ15 HAL CYP4F3 NA NA NA NA NA NA NA 0,83092286 0,9881880

2 CYP4F3 CXCR1 NA NA NA NA NA NA NA NA 0,45629978 0,9881349

3 KCNJ15 CXCR2 CYP4F3 NA NA NA NA NA NA NA 0,84541741 0,9881218

6 NA HAL VNN3 CYP4F3 CXCR1 STEAP4 NA NA NA NA 0,80229722 0,9881050

5 CXC 2 FCGR3B HAL VNN3 CXCR1 NA NA NA NA NA 0,77088741 0,9881008

5 KCNJ15 CXCR2 HAL VNN3 CXCR1 NA NA NA NA NA 0,92016779 0,9880892

5 KCNJ15 CXCR2 NA CYP4F3 CXCR1 NA NA NA NA NA 0,87132918 0,9880751

4 CXC 2 FCGR3B HAL CYP4F3 NA NA NA NA NA NA 0,74220036 0,9880712

6 KCNJ15 NA VNN3 CYP4F3 CXCR1 STEAP4 NA NA NA NA 0,89406513 0,9880518

4 CXC 2 NA HAL VNN3 NA NA NA NA NA NA 0,86156045 0,9879658

7 NA FCGR3B HAL VNN3 CYP4F3 CXCR1 STEAP4 NA NA NA 0,87271815 0,9879426

5 KCNJ15 FCGR3B HAL VNN3 CXCR1 NA NA NA NA NA 0,90931464 0,9879395

4 CXCR2 NA HAL CXCR1 NA NA NA NA NA NA 0,88459917 0,9879389

4 CXCR2 NA CYP4F3 CXCR1 NA NA NA NA NA NA 0,77729697 0,9879248

5 NA FCGR3B VNN3 CYP4F3 STEAP4 NA NA NA NA NA 0,86263836 0,9879220

5 KCNJ15 CXCR2 NA FCGR3B CYP4F3 NA NA NA NA NA 0,8860428 0,9879145

6 KCNJ15 CXCR2 NA FCGR3B VNN3 CXCR1 NA NA NA NA 0,86758383 0,9878566

7 KCNJ15 NA FCGR3B VNN3 CYP4F3 CXCR1 STEAP4 NA NA NA 0,92797454 0,9878436

6 KCNJ15 CXCR2 NA FCGR3B CYP4F3 CXCR1 NA NA NA NA 0,89128043 0,9877889

5 CXCR2 NA FCGR3B CYP4F3 CXCR1 NA NA NA NA NA 0,82170994 0,987788

7 KCNJ15 NA HAL VNN3 CYP4F3 CXCR1 STEAP4 NA NA NA 0,91397247 0,9877786

4 KCNJ15 NA HAL CXCR1 NA NA NA NA NA NA 0,85947031 0,9877677

7 CXC 2 NA HAL VNN3 CYP4F3 CXCR1 STEAP4 NA NA NA 0,85500759 0,9877361

4 KCNJ15 CXCR2 VNN3 CXCR1 NA NA NA NA NA NA 0,8753944 0,9876870

4 VNN3 CYP4F3 CXCR1 STEAP4 NA NA NA NA NA NA 0,63647112 0,9876531

4 KCNJ15 FCGR3B HAL CYP4F3 NA NA NA NA NA NA 0,88673182 0,9876508

6 KCNJ15 CXCR2 FCGR3B HAL VNN3 CXCR1 NA NA NA NA 0,91122666 0,9876205

8 KCNJ15 NA FCGR3B HAL VNN3 CYP4F3 CXCR1 STEAP4 NA NA 0,9474518 0,9876171

5 KCNJ15 NA VNN3 CYP4F3 STEAP4 NA NA NA NA NA 0,88306664 0,9875971

5 KCNJ15 CXCR2 NA FCGR3B VNN3 NA NA NA NA NA 0,86079106 0,9875912

5 FCGR3B VNN3 CYP4F3 CXCR1 STEAP4 NA NA NA NA NA 0,75169271 0,9875671

2 KCNJ15 VNN3 NA NA NA NA NA NA NA NA 0,81435276 0,9875486

5 KCNJ15 VNN3 CYP4F3 CXCR1 STEAP4 NA NA NA NA NA 0,87786862 0,9875426

5 KCNJ15 CXCR2 FCGR3B HAL CYP4F3 NA NA NA NA NA 0,89973498 0,9875420

8 KCNJ15 CXCR2 NA HAL VNN3 CYP4F3 CXCR1 STEAP4 NA NA 0,93987638 0,9875417

5 CXC 2 NA FCGR3B HAL VNN3 NA NA NA NA NA 0,87410325 0,9875392

4 KCNJ15 CXCR2 CYP4F3 CXCR1 NA NA NA NA NA NA 0,8550842 0,9875293

8 CXC 2 NA FCGR3B HAL VNN3 CYP4F3 CXCR1 STEAP4 NA NA 0,8897327 0,9875282

6 CXCR2 NA VNN3 CYP4F3 CXCR1 STEAP4 NA NA NA NA 0,85491367 0,9875220

3 CXCR2 VNN3 CXCR1 NA NA NA NA NA NA NA 0,70450573 0,987517

5 CXCR2 NA VNN3 CYP4F3 STEAP4 NA NA NA NA NA 0,84596552 0,987458

6 NA HAL VNN3 CYP4F3 CXCR1 TNFRSF10C NA NA NA NA 0,77834002 0,9874543

7 KCNJ15 CXCR2 NA VNN3 CYP4F3 CXCR1 STEAP4 NA NA NA 0,92260015 0,987453

3 KCNJ15 CXCR2 VNN3 NA NA NA NA NA NA NA 0,86594044 0,9874426

5 KCNJ15 NA FCGR3B HAL CXCR1 NA NA NA NA NA 0,89807637 0,9874102

5 KCNJ15 CXCR2 NA HAL CXCR1 NA NA NA NA NA 0,90342852 0,9874026

4 NA FCGR3B HAL VNN3 NA NA NA NA NA NA 0,86107167 0,9873837

5 CXCR2 NA FCGR3B HAL CXCR1 NA NA NA NA NA 0,87397758 0,9873717

3 CXCR2 FCGR3B CYP4F3 NA NA NA NA NA NA NA 0,68878445 0,9873640

7 CXCR2 NA FCGR3B VNN3 CYP4F3 CXCR1 STEAP4 NA NA NA 0,88001133 0,9873599

4 CXC 2 FCGR3B VNN3 CXCR1 NA NA NA NA NA NA 0,70369802 0,9873534

6 KCNJ15 NA FCGR3B VNN3 CYP4F3 STEAP4 NA NA NA NA 0,92191325 0,9873519

6 KCNJ15 FCGR3B VNN3 CYP4F3 CXCR1 STEAP4 NA NA NA NA 0,91057394 0,9873469

3 CXC 2 FCGR3B VNN3 NA NA NA NA NA NA NA 0,69265575 0,9873455

9 KCNJ15 CXCR2 NA FCGR3B HAL VNN3 CYP4F3 CXCR1 STEAP4 NA 0,95361413 0,9873408

5 KCNJ15 CXCR2 NA HAL VNN3 NA NA NA NA NA 0,91187445 0,9873130

5 KCNJ15 CXCR2 FCGR3B VNN3 CXCR1 NA NA NA NA NA 0,85688312 0,9872816

4 KCNJ15 CXCR2 FCGR3B CYP4F3 NA NA NA NA NA NA 0,86319731 0,9872608

8 KCNJ15 CXCR2 NA FCGR3B VNN3 CYP4F3 CXCR1 STEAP4 NA NA 0,93312252 0,987257

2 NA FCGR3B NA NA NA NA NA NA NA NA 0,74023309 0,9872433

5 KCNJ15 CXCR2 FCGR3B CYP4F3 CXCR1 NA NA NA NA NA 0,86871339 0,9872255

6 KCNJ15 CXCR2 NA VNN3 CYP4F3 STEAP4 NA NA NA NA 0,91551349 0,9871827

3 KCNJ15 FCGR3B VNN3 NA NA NA NA NA NA NA 0,84309248 0,9871644

6 CXC 2 NA FCGR3B VNN3 CYP4F3 STEAP4 NA NA NA NA 0,87576059 0,987145

3 NA HAL VNN3 NA NA NA NA NA NA NA 0,77708536 0,9870877

7 NA FCGR3B HAL VNN3 CYP4F3 CXCR1 TNFRSF10C NA NA NA 0,85497837 0,9870534

6 KCNJ15 CXCR2 NA FCGR3B HAL VNN3 NA NA NA NA 0,92051041 0,9870134

6 KCNJ15 CXCR2 NA FCGR3B HAL CXCR1 NA NA NA NA 0,90920909 0,986983

6 FCGR3B HAL VNN3 CYP4F3 CXCR1 STEAP4 NA NA NA NA 0,76951229 0,9869535

7 KCNJ15 NA HAL VNN3 CYP4F3 CXCR1 TNFRSF10C NA NA NA 0,90313201 0,9869332

3 NA FCGR3B CXCR1 NA NA NA NA NA NA NA 0,75910919 0,9869282

6 KCNJ15 HAL VNN3 CYP4F3 CXCR1 STEAP4 NA NA NA NA 0,8843707 0,9869171

7 KCNJ15 CXCR2 NA FCGR3B VNN3 CYP4F3 STEAP4 NA NA NA 0,92890605 0,9869087

5 HAL VNN3 CYP4F3 CXCR1 STEAP4 NA NA NA NA NA 0,67143658 0,9869057

6 KCNJ15 CXCR2 VNN3 CYP4F3 CXCR1 STEAP4 NA NA NA NA 0,9079149 0,9868962

3 VNN3 CYP4F3 STEAP4 NA NA NA NA NA NA NA 0,60868055 0,9868842

7 KCNJ15 FCGR3B HAL VNN3 CYP4F3 CXCR1 STEAP4 NA NA NA 0,92178975 0,9868547

7 KCNJ15 CXCR2 HAL VNN3 CYP4F3 CXCR1 STEAP4 NA NA NA 0,91461743 0,9868300

4 FCGR3B VNN3 CYP4F3 STEAP4 NA NA NA NA NA NA 0,73845963 0,986800

7 CXC 2 NA HAL VNN3 CYP4F3 CXCR1 TNFRSF10C NA NA NA 0,83518954 0,9868003

6 CXCR2 HAL VNN3 CYP4F3 CXCR1 STEAP4 NA NA NA NA 0,74692547 0,9867740

4 CXC 2 FCGR3B CYP4F3 CXCR1 NA NA NA NA NA NA 0,70076915 0,9867695

5 KCNJ15 NA FCGR3B HAL VNN3 NA NA NA NA NA 0,91058525 0,9867538

7 KCNJ15 CXCR2 FCGR3B VNN3 CYP4F3 CXCR1 STEAP4 NA NA NA 0,91314166 0,9867082

8 KCNJ15 CXCR2 FCGR3B HAL VNN3 CYP4F3 CXCR1 STEAP4 NA NA 0,92856345 0,9866741

5 CXC 2 VNN3 CYP4F3 CXCR1 STEAP4 NA NA NA NA NA 0,73037467 0,98667

7 CXCR2 FCGR3B HAL VNN3 CYP4F3 CXCR1 STEAP4 NA NA NA 0,8023891 0,9866715

4 KCNJ15 NA FCGR3B CXCR1 NA NA NA NA NA NA 0,80220091 0,9866692

8 KCNJ15 NA FCGR3B HAL VNN3 CYP4F3 CXCR1 TNFRSF10C NA NA 0,93885439 0,986650

4 KCNJ15 VNN3 CYP4F3 STEAP4 NA NA NA NA NA NA 0,86517604 0,9866442

4 KCNJ15 CXCR2 FCGR3B VNN3 NA NA NA NA NA NA 0,85043617 0,9866439

4 KCNJ15 NA HAL VNN3 NA NA NA NA NA NA 0,87086587 0,9866402

5 HAL VNN3 CYP4F3 CXCR1 TNFRSF10C NA NA NA NA NA 0,64209542 0,9866348

3 KCNJ15 NA CXCR1 NA NA NA NA NA NA NA 0,73891147 0,9866325

6 CXCR2 FCGR3B VNN3 CYP4F3 CXCR1 STEAP4 NA NA NA NA 0,78295949 0,9866014

3 CXCR2 CYP4F3 CXCR1 NA NA NA NA NA NA NA 0,61228503 0,9866013

6 CXCR2 NA HAL VNN3 CYP4F3 STEAP4 NA NA NA NA 0,84595632 0,9865684

8 KCNJ15 CXCR2 NA HAL VNN3 CYP4F3 CXCR1 TNFRSF10C NA NA 0,93034896 0,9865472

7 KCNJ15 CXCR2 NA HAL VNN3 CYP4F3 STEAP4 NA NA NA 0,93369509 0,986514

6 NA FCGR3B HAL CYP4F3 CXCR1 STEAP4 NA NA NA NA 0,87359693 0,9864957

5 NA HAL CYP4F3 CXCR1 STEAP4 NA NA NA NA NA 0,79855291 0,9864854

7 CXCR2 NA FCGR3B HAL VNN3 CYP4F3 STEAP4 NA NA NA 0,88498349 0,9864837

5 KCNJ15 FCGR3B VNN3 CYP4F3 STEAP4 NA NA NA NA NA 0,90405255 0,9864834

6 KCNJ15 NA HAL CYP4F3 CXCR1 STEAP4 NA NA NA NA 0,90588583 0,9864799

8 CXCR2 NA FCGR3B HAL VNN3 CYP4F3 CXCR1 TNFRSF10C NA NA 0,87408842 0,9864741

6 NA FCGR3B HAL VNN3 CYP4F3 STEAP4 NA NA NA NA 0,86539504 0,9864588

7 KCNJ15 NA FCGR3B HAL CYP4F3 CXCR1 STEAP4 NA NA NA 0,94122334 0,98641

8 KCNJ15 CXCR2 NA FCGR3B HAL VNN3 CYP4F3 STEAP4 NA NA 0,94992324 0,9864006

5 KCNJ15 CXCR2 VNN3 CYP4F3 STEAP4 NA NA NA NA NA 0,90027688 0,9863728

5 KCNJ15 NA CYP4F3 CXCR1 STEAP4 NA NA NA NA NA 0,8653526 0,9863648

7 KCNJ15 NA FCGR3B HAL VNN3 CYP4F3 STEAP4 NA NA NA 0,94218192 0,986336

6 KCNJ15 NA FCGR3B CYP4F3 CXCR1 STEAP4 NA NA NA NA 0,90531371 0,9863299

7 KCNJ15 CXCR2 NA HAL CYP4F3 CXCR1 STEAP4 NA NA NA 0,93515937 0,9863214

5 NA HAL VNN3 CYP4F3 STEAP4 NA NA NA NA NA 0,78771851 0,9863063

6 KCNJ15 NA HAL VNN3 CYP4F3 STEAP4 NA NA NA NA 0,90476356 0,9862942

9 KCNJ15 CXCR2 NA FCGR3B HAL VNN3 CYP4F3 CXCR1 TNFRSF10C NA 0,94540756 0,9862873

4 CXC 2 VNN3 CYP4F3 STEAP4 NA NA NA NA NA NA 0,71425633 0,9862782

5 NA FCGR3B CYP4F3 CXCR1 STEAP4 NA NA NA NA NA 0,85103166 0,9862767

6 CXC 2 NA HAL CYP4F3 CXCR1 STEAP4 NA NA NA NA 0,85775665 0,9862280

6 FCGR3B HAL VNN3 CYP4F3 CXCR1 TNFRSF10C NA NA NA NA 0,74810743 0,9862118

6 KCNJ15 HAL VNN3 CYP4F3 CXCR1 TNFRSF10C NA NA NA NA 0,8737422 0,986207

8 KCNJ15 CXCR2 NA FCGR3B HAL CYP4F3 CXCR1 STEAP4 NA NA 0,94831408 0,9861920

4 KCNJ15 CXCR2 HAL CXCR1 NA NA NA NA NA NA 0,91493653 0,9861566

7 CXC 2 NA FCGR3B HAL CYP4F3 CXCR1 STEAP4 NA NA NA 0,89043377 0,986146

2 NA CXCR1 NA NA NA NA NA NA NA NA 0,67392652 0,9861322

6 KCNJ15 CXCR2 FCGR3B VNN3 CYP4F3 STEAP4 NA NA NA NA 0,9086425 0,9861151

4 NA CYP4F3 CXCR1 STEAP4 NA NA NA NA NA NA 0,76873917 0,9861140

3 FCGR3B HAL CXCR1 NA NA NA NA NA NA NA 0,72380099 0,9861088

5 CXCR2 FCGR3B VNN3 CYP4F3 STEAP4 NA NA NA NA NA 0,77437671 0,986072

5 NA VNN3 CYP4F3 CXCR1 TNFRSF10C NA NA NA NA NA 0,75931407 0,9860322

6 CXCR2 HAL VNN3 CYP4F3 CXCR1 TNFRSF10C NA NA NA NA 0,72309325 0,9859602

3 KCNJ15 HAL CXCR1 NA NA NA NA NA NA NA 0,8746979 0,9859572

6 KCNJ15 NA VNN3 CYP4F3 CXCR1 TNFRSF10C NA NA NA NA 0,87743952 0,985947

4 KCNJ15 FCGR3B HAL CXCR1 NA NA NA NA NA NA 0,89581793 0,9859304

7 KCNJ15 FCGR3B HAL VNN3 CYP4F3 CXCR1 TNFRSF10C NA NA NA 0,91350231 0,9859207

6 NA FCGR3B VNN3 CYP4F3 CXCR1 TNFRSF10C NA NA NA NA 0,84276236 0,9859198

3 CXCR2 HAL CXCR1 NA NA NA NA NA NA NA 0,73883915 0,9859192

5 NA HAL VNN3 CYP4F3 TNFRSF10C NA NA NA NA NA 0,76805335 0,9859148

7 KCNJ15 CXCR2 HAL VNN3 CYP4F3 CXCR1 TNFRSF10C NA NA NA 0,90535497 0,9858560

7 KCNJ15 NA FCGR3B VNN3 CYP4F3 CXCR1 TNFRSF10C NA NA NA 0,91491157 0,9858258

6 KCNJ15 CXCR2 NA CYP4F3 CXCR1 STEAP4 NA NA NA NA 0,90112322 0,9858251

4 KCNJ15 CXCR2 NA CXCR1 NA NA NA NA NA NA 0,80702412 0,9858119

5 KCNJ15 CXCR2 FCGR3B HAL CXCR1 NA NA NA NA NA 0,89895263 0,9858067

5 KCNJ15 CXCR2 NA FCGR3B CXCR1 NA NA NA NA NA 0,82750846 0,985782

7 KCNJ15 CXCR2 NA FCGR3B CYP4F3 CXCR1 STEAP4 NA NA NA 0,91428999 0,9857764

6 CXC 2 NA HAL VNN3 CYP4F3 TNFRSF10C NA NA NA NA 0,83012609 0,985707

2 KCNJ15 NA NA NA NA NA NA NA NA NA 0,71285006 0,985664

6 NA FCGR3B HAL VNN3 CYP4F3 TNFRSF10C NA NA NA NA 0,85161006 0,985654

2 HAL CXCR1 NA NA NA NA NA NA NA NA 0,57934013 0,9856523

4 CXC 2 FCGR3B HAL CXCR1 NA NA NA NA NA NA 0,76048457 0,9856494

4 NA FCGR3B CYP4F3 STEAP4 NA NA NA NA NA NA 0,83975715 0,9856382

7 CXC 2 FCGR3B HAL VNN3 CYP4F3 CXCR1 TNFRSF10C NA NA NA 0,7840174 0,9856311

3 KCNJ15 NA FCGR3B NA NA NA NA NA NA NA 0,78702028 0,9856246

4 KCNJ15 NA CYP4F3 STEAP4 NA NA NA NA NA NA 0,8501858 0,9856062

8 KCNJ15 CXCR2 FCGR3B HAL VNN3 CYP4F3 CXCR1 TNFRSF10C NA NA 0,92043566 0,9855893

5 KCNJ15 NA FCGR3B CYP4F3 STEAP4 NA NA NA NA NA 0,89637451 0,9855694

4 NA VNN3 CYP4F3 TNFRSF10C NA NA NA NA NA NA 0,74916961 0,9855482

2 CXC 2 NA NA NA NA NA NA NA NA NA 0,78650347 0,985544

3 NA CYP4F3 STEAP4 NA NA NA NA NA NA NA 0,74357105 0,9855429

6 KCNJ15 NA HAL VNN3 CYP4F3 TNFRSF10C NA NA NA NA 0,89718355 0,9855229

7 KCNJ15 CXCR2 NA HAL VNN3 CYP4F3 TNFRSF10C NA NA NA 0,92708078 0,9855149

3 KCNJ15 CXCR2 NA NA NA NA NA NA NA NA 0,79007976 0,9855102

5 NA HAL CYP4F3 CXCR1 TNFRSF10C NA NA NA NA NA 0,77635266 0,9854965

6 CXCR2 NA FCGR3B CYP4F3 CXCR1 STEAP4 NA NA NA NA 0,86452199 0,9854613

7 CXCR2 NA FCGR3B HAL VNN3 CYP4F3 TNFRSF10C NA NA NA 0,87257253 0,9854210

5 KCNJ15 CXCR2 FCGR3B HAL VNN3 NA NA NA NA NA 0,9068159 0,9854095

7 KCNJ15 CXCR2 NA VNN3 CYP4F3 CXCR1 TNFRSF10C NA NA NA 0,90827113 0,9854093

4 KCNJ15 CXCR2 HAL VNN3 NA NA NA NA NA NA 0,91287666 0,9853706

7 KCNJ15 NA FCGR3B HAL VNN3 CYP4F3 TNFRSF10C NA NA NA 0,93640349 0,9853685

5 KCNJ15 FCGR3B CYP4F3 CXCR1 STEAP4 NA NA NA NA NA 0,88895172 0,9853523

5 KCNJ15 CXCR2 NA CYP4F3 STEAP4 NA NA NA NA NA 0,89094149 0,9853426

5 CXC 2 NA CYP4F3 CXCR1 STEAP4 NA NA NA NA NA 0,83943772 0,9853308

6 KCNJ15 NA HAL CYP4F3 CXCR1 TNFRSF10C NA NA NA NA 0,89707886 0,985316

8 KCNJ15 CXCR2 NA FCGR3B VNN3 CYP4F3 CXCR1 TNFRSF10C NA NA 0,92108421 0,9853164

4 KCNJ15 CXCR2 NA HAL NA NA NA NA NA NA 0,89208101 0,9853074

8 KCNJ15 CXCR2 NA FCGR3B HAL VNN3 CYP4F3 TNFRSF10C NA NA 0,94408168 0,9853037

5 NA FCGR3B VNN3 CYP4F3 TNFRSF10C NA NA NA NA NA 0,84165313 0,9852782

7 KCNJ15 CXCR2 FCGR3B HAL VNN3 CYP4F3 STEAP4 NA NA NA 0,92430694 0,985273

3 CXCR2 NA HAL NA NA NA NA NA NA NA 0,87340718 0,9852644

3 KCNJ15 FCGR3B CXCR1 NA NA NA NA NA NA NA 0,79562738 0,985263

4 CXC 2 NA FCGR3B CXCR1 NA NA NA NA NA NA 0,77991315 0,9852622

6 KCNJ15 FCGR3B HAL CYP4F3 CXCR1 STEAP4 NA NA NA NA 0,91839412 0,9852542

6 NA FCGR3B HAL CYP4F3 CXCR1 TNFRSF10C NA NA NA NA 0,85805098 0,9852487

4 KCNJ15 CYP4F3 CXCR1 STEAP4 NA NA NA NA NA NA 0,85084355 0,9852338

6 KCNJ15 CXCR2 HAL CYP4F3 CXCR1 STEAP4 NA NA NA NA 0,9136837 0,9852256

6 KCNJ15 CXCR2 NA FCGR3B CYP4F3 STEAP4 NA NA NA NA 0,90790585 0,9852242

6 KCNJ15 CXCR2 HAL VNN3 CYP4F3 STEAP4 NA NA NA NA 0,90745124 0,9852241

5 KCNJ15 NA VNN3 CYP4F3 TNFRSF10C NA NA NA NA NA 0,87059682 0,9852047

7 KCNJ15 CXCR2 FCGR3B HAL CYP4F3 CXCR1 STEAP4 NA NA NA 0,92529893 0,9852039

6 KCNJ15 NA FCGR3B VNN3 CXCR1 STEAP4 NA NA NA NA 0,86397561 0,9851957

6 CXC 2 NA VNN3 CYP4F3 CXCR1 TNFRSF10C NA NA NA NA 0,82483656 0,9851783

5 KCNJ15 CXCR2 NA FCGR3B HAL NA NA NA NA NA 0,90223566 0,9851764

4 CXCR2 NA FCGR3B HAL NA NA NA NA NA NA 0,86783917 0,9851729

4 CXCR2 FCGR3B HAL VNN3 NA NA NA NA NA NA 0,76209907 0,9851647

4 KCNJ15 CXCR2 NA FCGR3B NA NA NA NA NA NA 0,81691104 0,9851638

7 CXC 2 NA FCGR3B VNN3 CYP4F3 CXCR1 TNFRSF10C NA NA NA 0,8573051 0,9851443

7 KCNJ15 NA FCGR3B HAL CYP4F3 CXCR1 TNFRSF10C NA NA NA 0,93436738 0,9851407

5 KCNJ15 VNN3 CYP4F3 CXCR1 TNFRSF10C NA NA NA NA NA 0,86137974 0,985114

5 KCNJ15 HAL CYP4F3 CXCR1 STEAP4 NA NA NA NA NA 0,88016727 0,9851129

3 CXCR2 NA FCGR3B NA NA NA NA NA NA NA 0,76852055 0,9851015

6 KCNJ15 NA FCGR3B VNN3 CYP4F3 TNFRSF10C NA NA NA NA 0,91227212 0,9850552

7 KCNJ15 CXCR2 NA HAL CYP4F3 CXCR1 TNFRSF10C NA NA NA 0,92748724 0,9850146

6 KCNJ15 FCGR3B VNN3 CYP4F3 CXCR1 TNFRSF10C NA NA NA NA 0,89770555 0,9850137

5 CXC 2 NA FCGR3B CYP4F3 STEAP4 NA NA NA NA NA 0,85731352 0,9849689

7 KCNJ15 CXCR2 NA FCGR3B HAL CYP4F3 STEAP4 NA NA NA 0,94322933 0,9849663

4 CXC 2 NA CYP4F3 STEAP4 NA NA NA NA NA NA 0,82562246 0,9849645

6 CXCR2 FCGR3B HAL VNN3 CYP4F3 STEAP4 NA NA NA NA 0,79429084 0,9849589

6 KCNJ15 CXCR2 NA HAL CYP4F3 STEAP4 NA NA NA NA 0,92700919 0,9849508

5 NA FCGR3B VNN3 CXCR1 STEAP4 NA NA NA NA NA 0,83026545 0,9849459

6 CXCR2 NA HAL CYP4F3 CXCR1 TNFRSF10C NA NA NA NA 0,84002793 0,9849231

7 KCNJ15 CXCR2 NA FCGR3B VNN3 CXCR1 STEAP4 NA NA NA 0,87769479 0,9849111

4 VNN3 CYP4F3 CXCR1 TNFRSF10C NA NA NA NA NA NA 0,58940124 0,9848910

6 KCNJ15 FCGR3B HAL VNN3 CYP4F3 STEAP4 NA NA NA NA 0,91568245 0,9848664

5 FCGR3B VNN3 CYP4F3 CXCR1 TNFRSF10C NA NA NA NA NA 0,71932057 0,9848639

6 KCNJ15 CXCR2 NA VNN3 CYP4F3 TNFRSF10C NA NA NA NA 0,90479343 0,9848580

5 FCGR3B HAL CYP4F3 CXCR1 STEAP4 NA NA NA NA NA 0,76255737 0,9848534

8 KCNJ15 CXCR2 NA FCGR3B HAL VNN3 CXCR1 STEAP4 NA NA 0,93035785 0,9848507

5 KCNJ15 NA VNN3 CXCR1 STEAP4 NA NA NA NA NA 0,82423052 0,9848506

8 KCNJ15 CXCR2 NA FCGR3B HAL CYP4F3 CXCR1 TNFRSF10C NA NA 0,94149698 0,9848487

6 KCNJ15 CXCR2 FCGR3B CYP4F3 CXCR1 STEAP4 NA NA NA NA 0,89495099 0,9848010

6 CXCR2 FCGR3B HAL CYP4F3 CXCR1 STEAP4 NA NA NA NA 0,79781438 0,9847846

5 CXCR2 NA VNN3 CYP4F3 TNFRSF10C NA NA NA NA NA 0,82190354 0,9847571

4 FCGR3B CYP4F3 CXCR1 STEAP4 NA NA NA NA NA NA 0,72237917 0,9847432

7 CXCR2 NA FCGR3B HAL CYP4F3 CXCR1 TNFRSF10C NA NA NA 0,87648581 0,9847418

5 KCNJ15 CXCR2 CYP4F3 CXCR1 STEAP4 NA NA NA NA NA 0,88889502 0,9847394

6 KCNJ15 CXCR2 NA VNN3 CXCR1 STEAP4 NA NA NA NA 0,86786889 0,9847392

6 KCNJ15 NA FCGR3B HAL CYP4F3 STEAP4 NA NA NA NA 0,9341181 0,9847156

3 CXC 2 NA CXCR1 NA NA NA NA NA NA NA 0,80314669 0,9847123

7 KCNJ15 CXCR2 NA FCGR3B VNN3 CYP4F3 TNFRSF10C NA NA NA 0,919639 0,9847105

5 CXC 2 HAL VNN3 CYP4F3 STEAP4 NA NA NA NA NA 0,73300406 0,9847097

2 KCNJ15 CXCR1 NA NA NA NA NA NA NA NA 0,7524258 0,9847026

3 CXC 2 HAL VNN3 NA NA NA NA NA NA NA 0,71229196 0,9846998

6 CXC 2 NA FCGR3B HAL CYP4F3 STEAP4 NA NA NA NA 0,88405986 0,9846975

7 KCNJ15 CXCR2 NA HAL VNN3 CXCR1 STEAP4 NA NA NA 0,92434241 0,9846760

7 KCNJ15 NA FCGR3B HAL VNN3 CXCR1 STEAP4 NA NA NA 0,92263411 0,9846603

5 CXCR2 HAL CYP4F3 CXCR1 STEAP4 NA NA NA NA NA 0,74093585 0,9846141

6 CXCR2 NA FCGR3B VNN3 CYP4F3 TNFRSF10C NA NA NA NA 0,85735407 0,984597

5 CXCR2 NA HAL CYP4F3 STEAP4 NA NA NA NA NA 0,84601442 0,9845459

6 KCNJ15 CXCR2 VNN3 CYP4F3 CXCR1 TNFRSF10C NA NA NA NA 0,89374816 0,9845238

7 CXCR2 NA FCGR3B HAL VNN3 CXCR1 STEAP4 NA NA NA 0,88784328 0,9845112

4 KCNJ15 NA FCGR3B HAL NA NA NA NA NA NA 0,88791968 0,9844753

6 CXCR2 NA FCGR3B VNN3 CXCR1 STEAP4 NA NA NA NA 0,83998113 0,9844708

5 KCNJ15 HAL VNN3 CYP4F3 STEAP4 NA NA NA NA NA 0,87338609 0,984469

7 KCNJ15 CXCR2 FCGR3B VNN3 CYP4F3 CXCR1 TNFRSF10C NA NA NA 0,90094801 0,9844682

5 KCNJ15 NA HAL CYP4F3 STEAP4 NA NA NA NA NA 0,89398419 0,9844493

5 NA FCGR3B HAL CYP4F3 STEAP4 NA NA NA NA NA 0,86388589 0,9843868

5 FCGR3B HAL VNN3 CYP4F3 STEAP4 NA NA NA NA NA 0,75768699 0,9843715

4 HAL CYP4F3 CXCR1 STEAP4 NA NA NA NA NA NA 0,65357435 0,9843638

4 KCNJ15 CXCR2 FCGR3B CXCR1 NA NA NA NA NA NA 0,81330426 0,9843076

6 KCNJ15 CXCR2 HAL VNN3 CYP4F3 TNFRSF10C NA NA NA NA 0,90186489 0,9842992

3 NA FCGR3B HAL NA NA NA NA NA NA NA 0,85687959 0,9842689

6 NA FCGR3B HAL VNN3 CXCR1 STEAP4 NA NA NA NA 0,87688788 0,9842658

6 KCNJ15 NA HAL VNN3 CXCR1 STEAP4 NA NA NA NA 0,89238921 0,9842350

4 KCNJ15 FCGR3B HAL VNN3 NA NA NA NA NA NA 0,90257898 0,9841804

7 KCNJ15 CXCR2 FCGR3B HAL VNN3 CYP4F3 TNFRSF10C NA NA NA 0,91903972 0,9841624

6 CXC 2 NA HAL VNN3 CXCR1 STEAP4 NA NA NA NA 0,87738156 0,9841276

4 NA VNN3 CXCR1 STEAP4 NA NA NA NA NA NA 0,77292477 0,9841273

5 CXC 2 HAL VNN3 CYP4F3 TNFRSF10C NA NA NA NA NA 0,71282392 0,9841256

9 KCNJ15 NA FCGR3B HAL VNN3 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA 0,95770896 0,9840769

5 KCNJ15 HAL CYP4F3 CXCR1 TNFRSF10C NA NA NA NA NA 0,87295686 0,9840454

3 KCNJ15 CXCR2 CXCR1 NA NA NA NA NA NA NA 0,82154976 0,9840381

10 KCNJ15 CXCR2 NA FCGR3B HAL VNN3 CYP4F3 CXCR1 TNFRSF10C STEAP4 0,96177406 0,9840377

9 KCNJ15 CXCR2 NA HAL VNN3 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA 0,95099874 0,9839941

3 CYP4F3 CXCR1 STEAP4 NA NA NA NA NA NA NA 0,58621299 0,9839897

5 CXC 2 NA VNN3 CXCR1 STEAP4 NA NA NA NA NA 0,84593271 0,9839891

6 KCNJ15 FCGR3B HAL VNN3 CYP4F3 TNFRSF10C NA NA NA NA 0,91090867 0,9839864

6 CXC 2 FCGR3B VNN3 CYP4F3 CXCR1 TNFRSF10C NA NA NA NA 0,75630372 0,9839860

8 KCNJ15 NA HAL VNN3 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA 0,92889712 0,9839739

5 KCNJ15 HAL VNN3 CYP4F3 TNFRSF10C NA NA NA NA NA 0,8669387 0,9839710

6 CXCR2 FCGR3B HAL VNN3 CYP4F3 TNFRSF10C NA NA NA NA 0,77903651 0,9839684

5 CXCR2 FCGR3B CYP4F3 CXCR1 STEAP4 NA NA NA NA NA 0,7603474 0,9839528

7 KCNJ15 NA FCGR3B HAL VNN3 CXCR1 TNFRSF10C NA NA NA 0,92446647 0,9839513

6 KCNJ15 FCGR3B HAL CYP4F3 CXCR1 TNFRSF10C NA NA NA NA 0,91275732 0,9839497

2 FCGR3B CXCR1 NA NA NA NA NA NA NA NA 0,57409036 0,9839254

4 KCNJ15 FCGR3B CYP4F3 STEAP4 NA NA NA NA NA NA 0,87887513 0,9839232

8 KCNJ15 CXCR2 NA FCGR3B HAL VNN3 CXCR1 TNFRSF10C NA NA 0,9303282 0,9839203

7 KCNJ15 CXCR2 NA HAL VNN3 CXCR1 TNFRSF10C NA NA NA 0,92668733 0,9839176

6 NA FCGR3B HAL VNN3 CXCR1 TNFRSF10C NA NA NA NA 0,8790553 0,9839010

5 CXCR2 VNN3 CYP4F3 CXCR1 TNFRSF10C NA NA NA NA NA 0,69386529 0,983890

5 FCGR3B HAL VNN3 CYP4F3 TNFRSF10C NA NA NA NA NA 0,73995934 0,9838775

8 NA FCGR3B HAL VNN3 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA 0,89111414 0,9838738

6 KCNJ15 CXCR2 HAL CYP4F3 CXCR1 TNFRSF10C NA NA NA NA 0,90735439 0,9838730

6 KCNJ15 NA HAL VNN3 CXCR1 TNFRSF10C NA NA NA NA 0,89561791 0,983853

4 HAL VNN3 CYP4F3 TNFRSF10C NA NA NA NA NA NA 0,62480608 0,9838520

4 KCNJ15 VNN3 CYP4F3 TNFRSF10C NA NA NA NA NA NA 0,8548462 0,9838397

3 KCNJ15 NA HAL NA NA NA NA NA NA NA 0,84144018 0,9838214

5 KCNJ15 CXCR2 FCGR3B CYP4F3 STEAP4 NA NA NA NA NA 0,88789564 0,9838212

4 HAL CYP4F3 CXCR1 TNFRSF10C NA NA NA NA NA NA 0,62428758 0,9837985

4 NA HAL CYP4F3 STEAP4 NA NA NA NA NA NA 0,77960603 0,983796

3 VNN3 CYP4F3 TNFRSF10C NA NA NA NA NA NA NA 0,5672645 0,983788

9 CXC 2 NA FCGR3B HAL VNN3 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA 0,90385089 0,9837785

4 KCNJ15 CXCR2 CYP4F3 STEAP4 NA NA NA NA NA NA 0,87738654 0,9837714

5 NA HAL VNN3 CXCR1 TNFRSF10C NA NA NA NA NA 0,82109038 0,9837690

5 KCNJ15 FCGR3B VNN3 CYP4F3 TNFRSF10C NA NA NA NA NA 0,89587228 0,9837678

8 KCNJ15 NA FCGR3B VNN3 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA 0,93755146 0,9837631

7 KCNJ15 CXCR2 FCGR3B HAL CYP4F3 CXCR1 TNFRSF10C NA NA NA 0,91914561 0,9837624

7 CXCR2 NA FCGR3B HAL VNN3 CXCR1 TNFRSF10C NA NA NA 0,88613642 0,9837114

5 FCGR3B HAL CYP4F3 CXCR1 TNFRSF10C NA NA NA NA NA 0,74268102 0,9837001

7 NA HAL VNN3 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA 0,83029595 0,9836950

8 CXC 2 NA HAL VNN3 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA 0,87534173 0,9836748

6 CXCR2 NA HAL VNN3 CXCR1 TNFRSF10C NA NA NA NA 0,88074568 0,9836710

6 KCNJ15 CXCR2 NA FCGR3B VNN3 STEAP4 NA NA NA NA 0,86913169 0,9836375

5 KCNJ15 CXCR2 VNN3 CYP4F3 TNFRSF10C NA NA NA NA NA 0,89119905 0,9836157

7 KCNJ15 NA VNN3 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA 0,90881855 0,9836131

4 FCGR3B VNN3 CYP4F3 TNFRSF10C NA NA NA NA NA NA 0,71162283 0,983612

6 KCNJ15 NA FCGR3B CYP4F3 CXCR1 TNFRSF10C NA NA NA NA 0,89335202 0,9836000

3 KCNJ15 CYP4F3 STEAP4 NA NA NA NA NA NA NA 0,83247235 0,9835966

6 KCNJ15 CXCR2 NA HAL CYP4F3 TNFRSF10C NA NA NA NA 0,92267724 0,983578

9 KCNJ15 CXCR2 NA FCGR3B VNN3 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA 0,94064257 0,9835258

6 KCNJ15 CXCR2 FCGR3B VNN3 CYP4F3 TNFRSF10C NA NA NA NA 0,90002946 0,983523

5 KCNJ15 FCGR3B VNN3 CXCR1 STEAP4 NA NA NA NA NA 0,85607217 0,9835233

7 KCNJ15 CXCR2 NA FCGR3B HAL CYP4F3 TNFRSF10C NA NA NA 0,93907392 0,9835198

6 KCNJ15 CXCR2 FCGR3B VNN3 CXCR1 STEAP4 NA NA NA NA 0,86373908 0,9834866

4 HAL VNN3 CYP4F3 STEAP4 NA NA NA NA NA NA 0,65058509 0,9834614

5 NA HAL VNN3 CXCR1 STEAP4 NA NA NA NA NA 0,81685454 0,9834447

4 CXC 2 CYP4F3 CXCR1 STEAP4 NA NA NA NA NA NA 0,70293423 0,9834299

7 NA FCGR3B VNN3 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA 0,88675219 0,9834246

8 KCNJ15 CXCR2 NA VNN3 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA 0,932953 0,9834092

5 KCNJ15 NA CYP4F3 CXCR1 TNFRSF10C NA NA NA NA NA 0,84989178 0,9833878

6 KCNJ15 NA FCGR3B HAL CYP4F3 TNFRSF10C NA NA NA NA 0,93045854 0,9833783

5 CXCR2 HAL CYP4F3 CXCR1 TNFRSF10C NA NA NA NA NA 0,71835788 0,9833654

5 KCNJ15 NA HAL CYP4F3 TNFRSF10C NA NA NA NA NA 0,88890209 0,9833114

6 CXC 2 FCGR3B HAL CYP4F3 CXCR1 TNFRSF10C NA NA NA NA 0,78079015 0,9833100

5 KCNJ15 NA FCGR3B VNN3 STEAP4 NA NA NA NA NA 0,85208843 0,9833053

6 KCNJ15 CXCR2 FCGR3B HAL CYP4F3 STEAP4 NA NA NA NA 0,91949611 0,9832954

7 KCNJ15 CXCR2 FCGR3B HAL VNN3 CXCR1 STEAP4 NA NA NA 0,9144177 0,9832781

5 KCNJ15 CXCR2 NA VNN3 STEAP4 NA NA NA NA NA 0,85466609 0,9832661

5 CXC 2 NA HAL CYP4F3 TNFRSF10C NA NA NA NA NA 0,83342541 0,9832541

7 KCNJ15 CXCR2 NA FCGR3B CYP4F3 CXCR1 TNFRSF10C NA NA NA 0,9031503 0,9832449

6 CXCR2 NA FCGR3B HAL CYP4F3 TNFRSF10C NA NA NA NA 0,87408836 0,9832100

5 NA FCGR3B HAL CYP4F3 TNFRSF10C NA NA NA NA NA 0,8533419 0,9831649

6 NA VNN3 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA 0,82698923 0,983142

4 NA HAL CYP4F3 TNFRSF10C NA NA NA NA NA NA 0,76292483 0,9830739

6 KCNJ15 CXCR2 NA CYP4F3 CXCR1 TNFRSF10C NA NA NA NA 0,88800116 0,9830678

8 CXCR2 NA FCGR3B VNN3 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA 0,89293638 0,9830630

6 KCNJ15 NA FCGR3B VNN3 CXCR1 TNFRSF10C NA NA NA NA 0,86039857 0,9830397

7 KCNJ15 CXCR2 NA FCGR3B HAL CXCR1 STEAP4 NA NA NA 0,91337735 0,9830183

5 KCNJ15 CXCR2 VNN3 CXCR1 STEAP4 NA NA NA NA NA 0,8716254 0,982996

3 FCGR3B CYP4F3 STEAP4 NA NA NA NA NA NA NA 0,70319676 0,9829888

4 CXCR2 VNN3 CYP4F3 TNFRSF10C NA NA NA NA NA NA 0,68345542 0,9829878

3 FCG 3B HAL VNN3 NA NA NA NA NA NA NA 0,7197283 0,9829867

5 CXC 2 FCGR3B VNN3 CYP4F3 TNFRSF10C NA NA NA NA NA 0,75197529 0,9829777

5 KCNJ15 CXCR2 HAL CYP4F3 STEAP4 NA NA NA NA NA 0,90423422 0,9829598

5 NA FCGR3B CYP4F3 CXCR1 TNFRSF10C NA NA NA NA NA 0,82563653 0,982957

5 CXC 2 NA FCGR3B VNN3 STEAP4 NA NA NA NA NA 0,83055992 0,982944

9 KCNJ15 CXCR2 FCGR3B HAL VNN3 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA 0,93930865 0,9829286

7 CXC 2 NA VNN3 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA 0,87429978 0,9828196

3 KCNJ15 HAL VNN3 NA NA NA NA NA NA NA 0,87188171 0,982816

8 KCNJ15 FCGR3B HAL VNN3 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA 0,93534237 0,9828097

2 KCNJ15 CXCR2 NA NA NA NA NA NA NA NA 0,80270188 0,9827858

7 KCNJ15 CXCR2 NA FCGR3B HAL VNN3 STEAP4 NA NA NA 0,92399289 0,9827824

7 KCNJ15 CXCR2 NA FCGR3B VNN3 CXCR1 TNFRSF10C NA NA NA 0,87308767 0,9827815

8 KCNJ15 CXCR2 HAL VNN3 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA 0,92927966 0,9827671

4 CXCR2 FCGR3B CYP4F3 STEAP4 NA NA NA NA NA NA 0,74794026 0,9827659

6 KCNJ15 CXCR2 HAL VNN3 CXCR1 STEAP4 NA NA NA NA 0,91789401 0,9827608

3 KCNJ15 CXCR2 FCGR3B NA NA NA NA NA NA NA 0,80170481 0,9827373

5 KCNJ15 NA VNN3 CXCR1 TNFRSF10C NA NA NA NA NA 0,82060409 0,9827011

9 KCNJ15 CXCR2 NA FCGR3B HAL VNN3 CYP4F3 TNFRSF10C STEAP4 NA 0,95932647 0,9826643

5 KCNJ15 NA FCGR3B CXCR1 STEAP4 NA NA NA NA NA 0,81676786 0,9826200

6 KCNJ15 FCGR3B HAL VNN3 CXCR1 STEAP4 NA NA NA NA 0,91006322 0,982605

6 KCNJ15 CXCR2 NA FCGR3B CXCR1 STEAP4 NA NA NA NA 0,83974168 0,9825907

4 KCNJ15 VNN3 CXCR1 STEAP4 NA NA NA NA NA NA 0,8302639 0,9825865

6 KCNJ15 CXCR2 NA HAL CXCR1 STEAP4 NA NA NA NA 0,90596913 0,9825749

5 NA FCGR3B VNN3 CXCR1 TNFRSF10C NA NA NA NA NA 0,82684542 0,9825607

6 KCNJ15 NA FCGR3B HAL CXCR1 STEAP4 NA NA NA NA 0,90201031 0,9825477

2 NA HAL NA NA NA NA NA NA NA NA 0,77284334 0,9825392

4 NA FCGR3B VNN3 STEAP4 NA NA NA NA NA NA 0,81558495 0,9825328

6 KCNJ15 CXCR2 NA VNN3 CXCR1 TNFRSF10C NA NA NA NA 0,86473119 0,9825302

7 KCNJ15 HAL VNN3 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA 0,90416201 0,9825299

7 KCNJ15 FCGR3B VNN3 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA 0,92314661 0,9825203

8 KCNJ15 CXCR2 NA FCGR3B VNN3 CYP4F3 TNFRSF10C STEAP4 NA NA 0,93786556 0,9825062

7 KCNJ15 NA FCGR3B VNN3 CYP4F3 TNFRSF10C STEAP4 NA NA NA 0,93338938 0,9824772

8 KCNJ15 CXCR2 NA HAL VNN3 CYP4F3 TNFRSF10C STEAP4 NA NA 0,94653432 0,9824610

5 KCNJ15 FCGR3B HAL CYP4F3 STEAP4 NA NA NA NA NA 0,91017925 0,9824577

9 KCNJ15 CXCR2 NA FCGR3B HAL CYP4F3 CXCR1 TNFRSF10C STEAP4 NA 0,95729158 0,9824255

6 CXC 2 NA FCGR3B CYP4F3 CXCR1 TNFRSF10C NA NA NA NA 0,84282217 0,9824243

4 NA CYP4F3 CXCR1 TNFRSF10C NA NA NA NA NA NA 0,73115126 0,9824241

7 KCNJ15 CXCR2 FCGR3B HAL VNN3 CXCR1 TNFRSF10C NA NA NA 0,91791227 0,9824214

4 KCNJ15 CXCR2 FCGR3B HAL NA NA NA NA NA NA 0,89177992 0,9824114

4 KCNJ15 NA VNN3 STEAP4 NA NA NA NA NA NA 0,80462594 0,9823885

8 KCNJ15 CXCR2 FCGR3B VNN3 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA 0,92304068 0,9823675

8 CXCR2 FCGR3B HAL VNN3 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA 0,8230547 0,9823585

8 KCNJ15 NA FCGR3B HAL VNN3 CYP4F3 TNFRSF10C STEAP4 NA NA 0,95402437 0,9823284

8 KCNJ15 NA FCGR3B HAL CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA 0,95262392 0,9823221

7 KCNJ15 CXCR2 NA VNN3 CYP4F3 TNFRSF10C STEAP4 NA NA NA 0,92795878 0,9823139

5 KCNJ15 NA FCGR3B CYP4F3 TNFRSF10C NA NA NA NA NA 0,88810783 0,982297

5 CXC 2 FCGR3B HAL CYP4F3 STEAP4 NA NA NA NA NA 0,7875391 0,9822495

6 KCNJ15 CXCR2 NA FCGR3B CYP4F3 TNFRSF10C NA NA NA NA 0,89976359 0,9822438

6 CXC 2 FCGR3B HAL VNN3 CXCR1 STEAP4 NA NA NA NA 0,79383978 0,9822376

5 CXCR2 FCGR3B VNN3 CXCR1 STEAP4 NA NA NA NA NA 0,73368828 0,9822304

7 FCGR3B HAL VNN3 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA 0,79635336 0,9822287

6 KCNJ15 CXCR2 HAL VNN3 CXCR1 TNFRSF10C NA NA NA NA 0,92802434 0,9822271

8 KCNJ15 CXCR2 NA HAL CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA 0,94747129 0,9822250

3 CXCR2 FCGR3B CXCR1 NA NA NA NA NA NA NA 0,64110903 0,9822069

6 KCNJ15 VNN3 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA 0,89741079 0,9821998

4 FCGR3B VNN3 CXCR1 STEAP4 NA NA NA NA NA NA 0,69857041 0,9821895

6 KCNJ15 NA VNN3 CYP4F3 TNFRSF10C STEAP4 NA NA NA NA 0,90060453 0,9821742

6 KCNJ15 CXCR2 NA HAL VNN3 STEAP4 NA NA NA NA 0,91445405 0,9821637

8 CXC 2 NA FCGR3B HAL VNN3 CYP4F3 TNFRSF10C STEAP4 NA NA 0,90106676 0,9821632

2 KCNJ15 FCGR3B NA NA NA NA NA NA NA NA 0,77819637 0,9821537

3 CXC 2 CYP4F3 STEAP4 NA NA NA NA NA NA NA 0,68001016 0,9821515

6 KCNJ15 FCGR3B HAL VNN3 CXCR1 TNFRSF10C NA NA NA NA 0,91786785 0,9821482

7 KCNJ15 CXCR2 VNN3 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA 0,92139086 0,9821194

6 CXC 2 NA FCGR3B HAL CXCR1 STEAP4 NA NA NA NA 0,87847531 0,9820856

4 CXC 2 NA VNN3 STEAP4 NA NA NA NA NA NA 0,82963649 0,982064

7 CXCR2 HAL VNN3 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA 0,77628559 0,9820496

5 KCNJ15 CXCR2 NA CYP4F3 TNFRSF10C NA NA NA NA NA 0,88176435 0,9820460

6 CXCR2 NA FCGR3B VNN3 CXCR1 TNFRSF10C NA NA NA NA 0,8319223 0,9820328

7 KCNJ15 NA HAL CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA 0,92265974 0,9820161

5 KCNJ15 FCGR3B CYP4F3 CXCR1 TNFRSF10C NA NA NA NA NA 0,87808214 0,9819889

5 KCNJ15 CXCR2 NA CXCR1 STEAP4 NA NA NA NA NA 0,82043778 0,9819881

4 KCNJ15 NA CYP4F3 TNFRSF10C NA NA NA NA NA NA 0,83918632 0,981977

5 CXCR2 NA CYP4F3 CXCR1 TNFRSF10C NA NA NA NA NA 0,81053126 0,9819573

6 NA FCGR3B VNN3 CYP4F3 TNFRSF10C STEAP4 NA NA NA NA 0,88338676 0,9819540

7 KCNJ15 NA HAL VNN3 CYP4F3 TNFRSF10C STEAP4 NA NA NA 0,9218655 0,9819535

4 NA VNN3 CXCR1 TNFRSF10C NA NA NA NA NA NA 0,77768144 0,9819277

7 CXCR2 NA FCGR3B VNN3 CYP4F3 TNFRSF10C STEAP4 NA NA NA 0,89109795 0,9819045

7 KCNJ15 CXCR2 NA FCGR3B HAL VNN3 TNFRSF10C NA NA NA 0,92731574 0,9818772

7 CXCR2 NA HAL VNN3 CYP4F3 TNFRSF10C STEAP4 NA NA NA 0,86917531 0,9818279

6 CXCR2 NA FCGR3B HAL VNN3 STEAP4 NA NA NA NA 0,88064652 0,9818249

8 CXCR2 NA FCGR3B HAL CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA 0,90584075 0,981800

7 NA FCGR3B HAL VNN3 CYP4F3 TNFRSF10C STEAP4 NA NA NA 0,88643531 0,9817632

7 KCNJ15 CXCR2 NA FCGR3B HAL CXCR1 TNFRSF10C NA NA NA 0,91558602 0,9817530

6 KCNJ15 CXCR2 FCGR3B HAL CYP4F3 TNFRSF10C NA NA NA NA 0,91666259 0,9817452

6 FCGR3B VNN3 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA 0,78111365 0,9817398

6 HAL VNN3 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA 0,71050084 0,9817386

6 KCNJ15 CXCR2 FCGR3B CYP4F3 CXCR1 TNFRSF10C NA NA NA NA 0,88418867 0,9817374

5 KCNJ15 HAL VNN3 CXCR1 TNFRSF10C NA NA NA NA NA 0,89995465 0,9817094

7 NA FCGR3B HAL CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA 0,89406319 0,9816934

6 KCNJ15 NA FCGR3B HAL VNN3 STEAP4 NA NA NA NA 0,91377961 0,9816930

6 CXC 2 FCGR3B HAL VNN3 CXCR1 TNFRSF10C NA NA NA NA 0,79002264 0,9816833

5 KCNJ15 NA HAL CXCR1 STEAP4 NA NA NA NA NA 0,86674517 0,9816800

3 KCNJ15 CXCR2 HAL NA NA NA NA NA NA NA 0,90333397 0,9816735

4 KCNJ15 NA CXCR1 STEAP4 NA NA NA NA NA NA 0,76216087 0,981629

2 CYP4F3 STEAP4 NA NA NA NA NA NA NA NA 0,54709233 0,9815866

5 KCNJ15 CXCR2 HAL CYP4F3 TNFRSF10C NA NA NA NA NA 0,90231923 0,9815809

6 CXCR2 NA VNN3 CYP4F3 TNFRSF10C STEAP4 NA NA NA NA 0,86933593 0,9815516

6 KCNJ15 CXCR2 NA HAL VNN3 TNFRSF10C NA NA NA NA 0,92132352 0,9815409

7 KCNJ15 NA FCGR3B CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA 0,91686782 0,9815308

5 KCNJ15 HAL VNN3 CXCR1 STEAP4 NA NA NA NA NA 0,8854537 0,9815196

6 KCNJ15 NA FCGR3B HAL CXCR1 TNFRSF10C NA NA NA NA 0,90674951 0,9815152

7 CXC 2 FCGR3B VNN3 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA 0,80456594 0,9814990

4 NA FCGR3B CYP4F3 TNFRSF10C NA NA NA NA NA NA 0,8214352 0,981497

4 KCNJ15 HAL CYP4F3 STEAP4 NA NA NA NA NA NA 0,86584255 0,9814969

5 CXC 2 NA VNN3 CXCR1 TNFRSF10C NA NA NA NA NA 0,84668654 0,9814911

4 KCNJ15 CYP4F3 CXCR1 TNFRSF10C NA NA NA NA NA NA 0,83705354 0,9814884

6 KCNJ15 CXCR2 NA HAL CXCR1 TNFRSF10C NA NA NA NA 0,91196477 0,9814807

8 KCNJ15 CXCR2 NA FCGR3B CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA 0,92325439 0,9814698

5 NA VNN3 CYP4F3 TNFRSF10C STEAP4 NA NA NA NA NA 0,8157824 0,9814526

7 CXCR2 NA HAL CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA 0,88043804 0,9814475

5 FCGR3B HAL VNN3 CXCR1 TNFRSF10C NA NA NA NA NA 0,76187495 0,981420

4 CXCR2 HAL CYP4F3 STEAP4 NA NA NA NA NA NA 0,72326923 0,9813686

5 NA FCGR3B HAL CXCR1 STEAP4 NA NA NA NA NA 0,86671648 0,9813496

5 KCNJ15 CXCR2 CYP4F3 CXCR1 TNFRSF10C NA NA NA NA NA 0,87710907 0,9813356

5 CXCR2 NA FCGR3B CYP4F3 TNFRSF10C NA NA NA NA NA 0,84074202 0,9812727

5 CXCR2 HAL VNN3 CXCR1 TNFRSF10C NA NA NA NA NA 0,75915813 0,981267

5 KCNJ15 CXCR2 FCGR3B VNN3 STEAP4 NA NA NA NA NA 0,85434067 0,9812297

6 KCNJ15 CXCR2 NA FCGR3B VNN3 TNFRSF10C NA NA NA NA 0,86812061 0,9811917

6 NA HAL CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA 0,83081208 0,9811832

6 CXC 2 NA FCGR3B HAL VNN3 TNFRSF10C NA NA NA NA 0,88524576 0,9811786

6 NA HAL VNN3 CYP4F3 TNFRSF10C STEAP4 NA NA NA NA 0,81946211 0,9811720

5 CXCR2 NA HAL CXCR1 STEAP4 NA NA NA NA NA 0,87609687 0,9811694

5 CXC 2 NA FCGR3B CXCR1 STEAP4 NA NA NA NA NA 0,79471932 0,981168

4 NA FCGR3B CXCR1 STEAP4 NA NA NA NA NA NA 0,76915296 0,9811355

5 KCNJ15 FCGR3B HAL CYP4F3 TNFRSF10C NA NA NA NA NA 0,90868608 0,9811311

6 KCNJ15 NA FCGR3B HAL VNN3 TNFRSF10C NA NA NA NA 0,91973855 0,981127

5 CXC 2 HAL VNN3 CXCR1 STEAP4 NA NA NA NA NA 0,75826357 0,9811215

5 FCGR3B HAL VNN3 CXCR1 STEAP4 NA NA NA NA NA 0,76258687 0,9811123

5 VNN3 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA NA 0,68514249 0,981107

7 KCNJ15 CXCR2 NA CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA 0,91351867 0,9810888

5 KCNJ15 FCGR3B VNN3 CXCR1 TNFRSF10C NA NA NA NA NA 0,85957666 0,9810511

6 KCNJ15 NA CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA 0,88312125 0,9810485

5 KCNJ15 NA HAL CXCR1 TNFRSF10C NA NA NA NA NA 0,87406944 0,9810346

6 KCNJ15 CXCR2 FCGR3B VNN3 CXCR1 TNFRSF10C NA NA NA NA 0,86284352 0,9809997

8 KCNJ15 CXCR2 FCGR3B HAL VNN3 CYP4F3 TNFRSF10C STEAP4 NA NA 0,93658473 0,9809961

6 CXCR2 VNN3 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA 0,76326779 0,9809873

9 KCNJ15 CXCR2 NA FCGR3B HAL VNN3 CXCR1 TNFRSF10C STEAP4 NA 0,93430074 0,9809116

6 CXCR2 NA FCGR3B HAL CXCR1 TNFRSF10C NA NA NA NA 0,88277133 0,9809014

7 KCNJ15 CXCR2 FCGR3B VNN3 CYP4F3 TNFRSF10C STEAP4 NA NA NA 0,92036444 0,9808661

8 KCNJ15 CXCR2 FCGR3B HAL CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA 0,93706974 0,9808623

4 CXCR2 VNN3 CXCR1 STEAP4 NA NA NA NA NA NA 0,7149063 0,980851

5 KCNJ15 NA FCGR3B VNN3 TNFRSF10C NA NA NA NA NA 0,85299835 0,9808411

4 FCGR3B HAL CYP4F3 STEAP4 NA NA NA NA NA NA 0,74745265 0,9808369

3 NA CYP4F3 TNFRSF10C NA NA NA NA NA NA NA 0,71461174 0,980832

4 CXCR2 NA CYP4F3 TNFRSF10C NA NA NA NA NA NA 0,8043435 0,9807640

5 KCNJ15 CXCR2 NA VNN3 TNFRSF10C NA NA NA NA NA 0,85660385 0,9807414

5 CXC 2 FCGR3B HAL CYP4F3 TNFRSF10C NA NA NA NA NA 0,77438677 0,980726

5 NA FCGR3B HAL CXCR1 TNFRSF10C NA NA NA NA NA 0,87907319 0,9806899

6 KCNJ15 CXCR2 FCGR3B HAL CXCR1 STEAP4 NA NA NA NA 0,89928565 0,9806533

5 CXCR2 NA HAL VNN3 STEAP4 NA NA NA NA NA 0,86436909 0,9806439

8 KCNJ15 CXCR2 NA FCGR3B HAL CYP4F3 TNFRSF10C STEAP4 NA NA 0,95364332 0,9806365

4 KCNJ15 HAL CYP4F3 TNFRSF10C NA NA NA NA NA NA 0,863662 0,9806155

4 HAL VNN3 CXCR1 TNFRSF10C NA NA NA NA NA NA 0,65542935 0,9806133

5 KCNJ15 CXCR2 NA FCGR3B STEAP4 NA NA NA NA NA 0,82783009 0,9806122

5 CXC 2 NA HAL VNN3 TNFRSF10C NA NA NA NA NA 0,87796288 0,980607

6 KCNJ15 FCGR3B VNN3 CYP4F3 TNFRSF10C STEAP4 NA NA NA NA 0,91912884 0,9805509

7 KCNJ15 CXCR2 HAL VNN3 CYP4F3 TNFRSF10C STEAP4 NA NA NA 0,92430589 0,9805337

6 NA FCGR3B CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA 0,87143651 0,9804995

7 KCNJ15 FCGR3B HAL CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA 0,9334276 0,9804848

7 KCNJ15 CXCR2 HAL CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA 0,92990301 0,9804400

3 NA VNN3 STEAP4 NA NA NA NA NA NA NA 0,73863429 0,9804380

5 KCNJ15 CXCR2 VNN3 CXCR1 TNFRSF10C NA NA NA NA NA 0,87892947 0,9804350

6 KCNJ15 CXCR2 VNN3 CYP4F3 TNFRSF10C STEAP4 NA NA NA NA 0,91656127 0,9804350

4 FCGR3B CYP4F3 CXCR1 TNFRSF10C NA NA NA NA NA NA 0,69022249 0,9804249

7 CXCR2 NA FCGR3B CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA 0,87950208 0,9804129

8 KCNJ15 NA FCGR3B HAL VNN3 CXCR1 TNFRSF10C STEAP4 NA NA 0,9279819 0,9804089

8 KCNJ15 CXCR2 NA HAL VNN3 CXCR1 TNFRSF10C STEAP4 NA NA 0,92964947 0,9804025

1 FCGR3B NA NA NA NA NA NA NA NA NA 0,53484838 0,9803913

5 CXCR2 NA HAL CXCR1 TNFRSF10C NA NA NA NA NA 0,89401824 0,9803823

5 KCNJ15 NA HAL VNN3 STEAP4 NA NA NA NA NA 0,87776869 0,9803711

5 KCNJ15 NA HAL VNN3 TNFRSF10C NA NA NA NA NA 0,88609364 0,9803590

4 CXCR2 HAL CYP4F3 TNFRSF10C NA NA NA NA NA NA 0,70542247 0,9803073

3 CXCR2 FCGR3B HAL NA NA NA NA NA NA NA 0,74785543 0,9802839

8 KCNJ15 CXCR2 NA FCGR3B VNN3 CXCR1 TNFRSF10C STEAP4 NA NA 0,8816968 0,980262

7 KCNJ15 FCGR3B HAL VNN3 CYP4F3 TNFRSF10C STEAP4 NA NA NA 0,93123941 0,980260

4 KCNJ15 VNN3 CXCR1 TNFRSF10C NA NA NA NA NA NA 0,84319554 0,9802594

5 NA FCGR3B HAL VNN3 TNFRSF10C NA NA NA NA NA 0,87672389 0,9802207

7 KCNJ15 CXCR2 NA HAL CYP4F3 TNFRSF10C STEAP4 NA NA NA 0,94133834 0,980178

6 KCNJ15 CXCR2 NA FCGR3B HAL STEAP4 NA NA NA NA 0,90466969 0,9801722

5 NA FCGR3B HAL VNN3 STEAP4 NA NA NA NA NA 0,86571551 0,9801393

5 CXC 2 FCGR3B CYP4F3 CXCR1 TNFRSF10C NA NA NA NA NA 0,73411407 0,9801087

5 KCNJ15 CXCR2 FCGR3B CXCR1 STEAP4 NA NA NA NA NA 0,8221733 0,980108

5 CXC 2 NA FCGR3B VNN3 TNFRSF10C NA NA NA NA NA 0,83070962 0,9801072

4 KCNJ15 CXCR2 VNN3 STEAP4 NA NA NA NA NA NA 0,85685852 0,9800915

5 KCNJ15 CXCR2 FCGR3B CYP4F3 TNFRSF10C NA NA NA NA NA 0,88112115 0,9800734

4 KCNJ15 NA VNN3 TNFRSF10C NA NA NA NA NA NA 0,80665958 0,9800205

7 KCNJ15 CXCR2 NA FCGR3B CYP4F3 TNFRSF10C STEAP4 NA NA NA 0,91855095 0,9800094

7 KCNJ15 NA FCGR3B VNN3 CXCR1 TNFRSF10C STEAP4 NA NA NA 0,86948579 0,9800021

7 KCNJ15 NA FCGR3B HAL CYP4F3 TNFRSF10C STEAP4 NA NA NA 0,94736965 0,9799994

6 KCNJ15 CXCR2 FCGR3B HAL VNN3 STEAP4 NA NA NA NA 0,90742205 0,9799660

8 CXC 2 NA FCGR3B HAL VNN3 CXCR1 TNFRSF10C STEAP4 NA NA 0,89397652 0,9799439

7 CXC 2 FCGR3B HAL VNN3 CYP4F3 TNFRSF10C STEAP4 NA NA NA 0,81733799 0,9799335

2 CXCR2 FCGR3B NA NA NA NA NA NA NA NA 0,6196135 0,9799310

4 FCGR3B HAL CYP4F3 TNFRSF10C NA NA NA NA NA NA 0,73225216 0,9798963

5 KCNJ15 VNN3 CYP4F3 TNFRSF10C STEAP4 NA NA NA NA NA 0,88866743 0,9798717

4 NA FCGR3B VNN3 TNFRSF10C NA NA NA NA NA NA 0,82546291 0,9798664

1 KCNJ15 NA NA NA NA NA NA NA NA NA 0,71751313 0,9798635

4 NA HAL CXCR1 TNFRSF10C NA NA NA NA NA NA 0,82868699 0,9798567

4 KCNJ15 FCGR3B VNN3 STEAP4 NA NA NA NA NA NA 0,84262651 0,9798437

6 KCNJ15 HAL CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA 0,90254172 0,9798427

6 CXCR2 NA CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA 0,8622009 0,979710

4 CXCR2 NA CXCR1 STEAP4 NA NA NA NA NA NA 0,79010298 0,9796873

7 CXCR2 FCGR3B HAL CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA 0,82088121 0,9796872

4 KCNJ15 FCGR3B CYP4F3 TNFRSF10C NA NA NA NA NA NA 0,87326686 0,979687

7 KCNJ15 CXCR2 FCGR3B CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA 0,90658774 0,9796832

6 KCNJ15 NA FCGR3B CYP4F3 TNFRSF10C STEAP4 NA NA NA NA 0,91016285 0,9796472

3 KCNJ15 FCGR3B HAL NA NA NA NA NA NA NA 0,88504544 0,9796430

7 KCNJ15 NA HAL VNN3 CXCR1 TNFRSF10C STEAP4 NA NA NA 0,90149094 0,9796381

6 CXC 2 FCGR3B VNN3 CYP4F3 TNFRSF10C STEAP4 NA NA NA NA 0,79915525 0,9796224

6 KCNJ15 CXCR2 NA FCGR3B CXCR1 TNFRSF10C NA NA NA NA 0,8358722 0,9796160

5 NA CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA NA 0,80518522 0,9796156

7 KCNJ15 CXCR2 NA VNN3 CXCR1 TNFRSF10C STEAP4 NA NA NA 0,8728584 0,9796048

7 CXC 2 NA FCGR3B HAL CYP4F3 TNFRSF10C STEAP4 NA NA NA 0,90183772 0,9795848

4 NA HAL CXCR1 STEAP4 NA NA NA NA NA NA 0,80449821 0,9795650

4 KCNJ15 NA FCGR3B STEAP4 NA NA NA NA NA NA 0,80047039 0,9795637

5 KCNJ15 CXCR2 HAL CXCR1 STEAP4 NA NA NA NA NA 0,90509552 0,9795543

4 FCGR3B VNN3 CXCR1 TNFRSF10C NA NA NA NA NA NA 0,69246123 0,9795284

4 KCNJ15 CXCR2 NA STEAP4 NA NA NA NA NA NA 0,80228691 0,9795254

3 VNN3 CXCR1 STEAP4 NA NA NA NA NA NA NA 0,57701415 0,9795237

6 KCNJ15 FCGR3B CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA 0,90398198 0,9795118

4 KCNJ15 CXCR2 CYP4F3 TNFRSF10C NA NA NA NA NA NA 0,87144764 0,9795029

4 KCNJ15 FCGR3B CXCR1 STEAP4 NA NA NA NA NA NA 0,80276735 0,9794685

6 KCNJ15 HAL VNN3 CYP4F3 TNFRSF10C STEAP4 NA NA NA NA 0,89602732 0,9794520

6 KCNJ15 CXCR2 NA CYP4F3 TNFRSF10C STEAP4 NA NA NA NA 0,90581378 0,9794459

5 KCNJ15 NA FCGR3B CXCR1 TNFRSF10C NA NA NA NA NA 0,81380716 0,9794176

6 KCNJ15 CXCR2 FCGR3B HAL CXCR1 TNFRSF10C NA NA NA NA 0,90668411 0,9793937

2 CXC 2 CXCR1 NA NA NA NA NA NA NA NA 0,65134471 0,9793524

5 CXCR2 FCGR3B VNN3 CXCR1 TNFRSF10C NA NA NA NA NA 0,72264283 0,9793212

5 KCNJ15 FCGR3B HAL CXCR1 STEAP4 NA NA NA NA NA 0,89217702 0,9793157

7 NA FCGR3B HAL VNN3 CXCR1 TNFRSF10C STEAP4 NA NA NA 0,88531438 0,9792699

6 KCNJ15 NA HAL CYP4F3 TNFRSF10C STEAP4 NA NA NA NA 0,91332895 0,9792500

4 CXCR2 NA VNN3 TNFRSF10C NA NA NA NA NA NA 0,84848266 0,979240

6 KCNJ15 CXCR2 FCGR3B HAL VNN3 TNFRSF10C NA NA NA NA 0,91548623 0,9792198

5 FCG 3B VNN3 CYP4F3 TNFRSF10C STEAP4 NA NA NA NA NA 0,77256923 0,9792147

6 FCGR3B HAL CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA 0,79320549 0,9791421

6 CXCR2 HAL VNN3 CYP4F3 TNFRSF10C STEAP4 NA NA NA NA 0,76579791 0,9791344

7 CXCR2 NA HAL VNN3 CXCR1 TNFRSF10C STEAP4 NA NA NA 0,88574991 0,9791291

6 KCNJ15 NA VNN3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA 0,83390911 0,9790907

4 CXCR2 CYP4F3 CXCR1 TNFRSF10C NA NA NA NA NA NA 0,66609534 0,9790171

3 CYP4F3 CXCR1 TNFRSF10C NA NA NA NA NA NA NA 0,53584713 0,9790157

6 KCNJ15 CXCR2 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA 0,90488721 0,9789948

5 KCNJ15 CXCR2 NA HAL STEAP4 NA NA NA NA NA 0,89264287 0,9789693

7 CXCR2 NA FCGR3B VNN3 CXCR1 TNFRSF10C STEAP4 NA NA NA 0,84342472 0,9789307

6 CXCR2 HAL CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA 0,77468603 0,978920

4 NA HAL VNN3 TNFRSF10C NA NA NA NA NA NA 0,80956111 0,9789061

6 FCGR3B HAL VNN3 CYP4F3 TNFRSF10C STEAP4 NA NA NA NA 0,78770467 0,9789004

6 KCNJ15 CXCR2 NA FCGR3B HAL TNFRSF10C NA NA NA NA 0,91049205 0,9788624

4 CXCR2 FCGR3B VNN3 STEAP4 NA NA NA NA NA NA 0,71812011 0,9788507

3 HAL CYP4F3 TNFRSF10C NA NA NA NA NA NA NA 0,6020042 0,9788311

5 KCNJ15 NA CYP4F3 TNFRSF10C STEAP4 NA NA NA NA NA 0,87123334 0,9788269

6 CXCR2 NA HAL CYP4F3 TNFRSF10C STEAP4 NA NA NA NA 0,87231027 0,9788210

5 CXCR2 VNN3 CYP4F3 TNFRSF10C STEAP4 NA NA NA NA NA 0,75248143 0,9787811

4 HAL VNN3 CXCR1 STEAP4 NA NA NA NA NA NA 0,65853338 0,9787547

8 KCNJ15 CXCR2 FCGR3B HAL VNN3 CXCR1 TNFRSF10C STEAP4 NA NA 0,91961231 0,9787503

3 KCNJ15 CYP4F3 TNFRSF10C NA NA NA NA NA NA NA 0,82566244 0,9787409

5 KCNJ15 CXCR2 NA CXCR1 TNFRSF10C NA NA NA NA NA 0,81832095 0,9787251

6 NA FCGR3B HAL CYP4F3 TNFRSF10C STEAP4 NA NA NA NA 0,88762406 0,9787171

4 KCNJ15 CXCR2 CXCR1 STEAP4 NA NA NA NA NA NA 0,81945601 0,9786852

5 KCNJ15 CXCR2 HAL CXCR1 TNFRSF10C NA NA NA NA NA 0,92341303 0,9786597

3 NA CXCR1 STEAP4 NA NA NA NA NA NA NA 0,67805072 0,9786110

5 KCNJ15 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA NA 0,87446102 0,9786000

6 CXC 2 NA FCGR3B CYP4F3 TNFRSF10C STEAP4 NA NA NA NA 0,87527661 0,9785814

6 NA FCGR3B VNN3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA 0,83366253 0,9785699

2 HAL VNN3 NA NA NA NA NA NA NA NA 0,56504539 0,9785328

5 KCNJ15 FCGR3B HAL CXCR1 TNFRSF10C NA NA NA NA NA 0,90583627 0,9785232

3 HAL CYP4F3 STEAP4 NA NA NA NA NA NA NA 0,62684976 0,9785068

5 KCNJ15 CXCR2 HAL VNN3 STEAP4 NA NA NA NA NA 0,90683775 0,9784466

3 NA VNN3 TNFRSF10C NA NA NA NA NA NA NA 0,76842078 0,9784395

8 KCNJ15 CXCR2 NA FCGR3B HAL CXCR1 TNFRSF10C STEAP4 NA NA 0,91837326 0,9784271

5 CXC 2 FCGR3B HAL CXCR1 STEAP4 NA NA NA NA NA 0,77871825 0,9783452

4 CXC 2 NA FCGR3B STEAP4 NA NA NA NA NA NA 0,77878161 0,9783319

8 KCNJ15 CXCR2 NA FCGR3B HAL VNN3 TNFRSF10C STEAP4 NA NA 0,92939221 0,9783067

5 KCNJ15 CXCR2 FCGR3B VNN3 TNFRSF10C NA NA NA NA NA 0,85873583 0,978293

5 KCNJ15 NA FCGR3B HAL STEAP4 NA NA NA NA NA 0,89002796 0,978290

5 KCNJ15 CXCR2 HAL VNN3 TNFRSF10C NA NA NA NA NA 0,92397296 0,9782613

7 KCNJ15 CXCR2 FCGR3B HAL CYP4F3 TNFRSF10C STEAP4 NA NA NA 0,93306541 0,9782444

4 KCNJ15 NA CXCR1 TNFRSF10C NA NA NA NA NA NA 0,75865784 0,9781611

5 NA FCGR3B CYP4F3 TNFRSF10C STEAP4 NA NA NA NA NA 0,86462564 0,9780830

5 CXC 2 NA FCGR3B HAL STEAP4 NA NA NA NA NA 0,86789617 0,9780661

6 NA HAL VNN3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA 0,83424287 0,9780214

7 KCNJ15 CXCR2 NA FCGR3B VNN3 TNFRSF10C STEAP4 NA NA NA 0,87484261 0,9780122

5 HAL CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA NA 0,69976948 0,9779794

5 KCNJ15 CXCR2 NA HAL TNFRSF10C NA NA NA NA NA 0,90356652 0,9779661

4 CXCR2 VNN3 CXCR1 TNFRSF10C NA NA NA NA NA NA 0,71901746 0,9779581

4 VNN3 CYP4F3 TNFRSF10C STEAP4 NA NA NA NA NA NA 0,66478849 0,9779206

7 KCNJ15 CXCR2 FCGR3B VNN3 CXCR1 TNFRSF10C STEAP4 NA NA NA 0,86825969 0,9779132

7 KCNJ15 CXCR2 HAL VNN3 CXCR1 TNFRSF10C STEAP4 NA NA NA 0,92405905 0,9778055

6 CXCR2 FCGR3B CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA 0,78548339 0,9778039

4 CXCR2 FCGR3B CYP4F3 TNFRSF10C NA NA NA NA NA NA 0,72682024 0,9777997

6 CXCR2 NA VNN3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA 0,84495869 0,9777880

7 KCNJ15 FCGR3B HAL VNN3 CXCR1 TNFRSF10C STEAP4 NA NA NA 0,91676973 0,9777034

3 VNN3 CXCR1 TNFRSF10C NA NA NA NA NA NA NA 0,58388353 0,9776900

5 CXC 2 NA CYP4F3 TNFRSF10C STEAP4 NA NA NA NA NA 0,85353795 0,9775460

4 NA HAL VNN3 STEAP4 NA NA NA NA NA NA 0,79341525 0,9775200

7 KCNJ15 CXCR2 NA HAL CXCR1 TNFRSF10C STEAP4 NA NA NA 0,91265096 0,9775137

7 KCNJ15 NA FCGR3B HAL CXCR1 TNFRSF10C STEAP4 NA NA NA 0,90884909 0,977508

5 KCNJ15 FCGR3B HAL VNN3 STEAP4 NA NA NA NA NA 0,90011692 0,9775055

5 HAL VNN3 CYP4F3 TNFRSF10C STEAP4 NA NA NA NA NA 0,69386704 0,9774898

5 CXCR2 NA FCGR3B CXCR1 TNFRSF10C NA NA NA NA NA 0,78950151 0,9774640

5 NA HAL CYP4F3 TNFRSF10C STEAP4 NA NA NA NA NA 0,81662579 0,9774592

5 FCGR3B CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA NA 0,75753349 0,9774569

6 KCNJ15 CXCR2 FCGR3B CYP4F3 TNFRSF10C STEAP4 NA NA NA NA 0,90170311 0,9774157

5 KCNJ15 FCGR3B HAL VNN3 TNFRSF10C NA NA NA NA NA 0,91396679 0,977410

5 CXC 2 FCGR3B HAL VNN3 STEAP4 NA NA NA NA NA 0,78211407 0,9773730

5 CXCR2 FCGR3B HAL CXCR1 TNFRSF10C NA NA NA NA NA 0,78182687 0,9773622

5 KCNJ15 NA FCGR3B HAL TNFRSF10C NA NA NA NA NA 0,89918556 0,977357

6 KCNJ15 CXCR2 HAL CYP4F3 TNFRSF10C STEAP4 NA NA NA NA 0,92309632 0,9773099

7 KCNJ15 CXCR2 NA HAL VNN3 TNFRSF10C STEAP4 NA NA NA 0,9219202 0,9772758

2 CXCR2 HAL NA NA NA NA NA NA NA NA 0,7150884 0,9772567

3 KCNJ15 NA STEAP4 NA NA NA NA NA NA NA 0,73630869 0,9772287

5 CXCR2 FCGR3B HAL VNN3 TNFRSF10C NA NA NA NA NA 0,78496767 0,9772245

4 KCNJ15 HAL CXCR1 TNFRSF10C NA NA NA NA NA NA 0,89090918 0,9772013

6 KCNJ15 FCGR3B VNN3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA 0,86158673 0,9771563

3 FCGR3B CYP4F3 TNFRSF10C NA NA NA NA NA NA NA 0,67784861 0,9771446

4 KCNJ15 HAL CXCR1 STEAP4 NA NA NA NA NA NA 0,86535469 0,9771211

4 NA FCGR3B CXCR1 TNFRSF10C NA NA NA NA NA NA 0,77048718 0,9771202

4 KCNJ15 CXCR2 VNN3 TNFRSF10C NA NA NA NA NA NA 0,87345527 0,9771158

7 KCNJ15 CXCR2 NA FCGR3B CXCR1 TNFRSF10C STEAP4 NA NA NA 0,84623973 0,9770556

3 KCNJ15 VNN3 STEAP4 NA NA NA NA NA NA NA 0,80591083 0,9769808

5 CXC 2 NA FCGR3B HAL TNFRSF10C NA NA NA NA NA 0,87996062 0,9769757

4 KCNJ15 FCGR3B VNN3 TNFRSF10C NA NA NA NA NA NA 0,85353117 0,9769741

5 KCNJ15 CXCR2 NA FCGR3B TNFRSF10C NA NA NA NA NA 0,8275053 0,9769670

5 NA VNN3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA NA 0,78101432 0,9769596

6 KCNJ15 NA FCGR3B VNN3 TNFRSF10C STEAP4 NA NA NA NA 0,85993783 0,9769430

6 KCNJ15 FCGR3B HAL CYP4F3 TNFRSF10C STEAP4 NA NA NA NA 0,92760371 0,9769270

7 CXCR2 FCGR3B HAL VNN3 CXCR1 TNFRSF10C STEAP4 NA NA NA 0,80835627 0,9769199

7 KCNJ15 NA FCGR3B HAL VNN3 TNFRSF10C STEAP4 NA NA NA 0,9210634 0,9769106

6 KCNJ15 CXCR2 NA VNN3 TNFRSF10C STEAP4 NA NA NA NA 0,86231085 0,9768923

3 KCNJ15 CXCR1 STEAP4 NA NA NA NA NA NA NA 0,75638352 0,9768440

6 KCNJ15 CXCR2 VNN3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA 0,87492373 0,9767168

7 CXC 2 NA FCGR3B HAL CXCR1 TNFRSF10C STEAP4 NA NA NA 0,8851392 0,9766521

4 CXC 2 FCGR3B CXCR1 STEAP4 NA NA NA NA NA NA 0,67604782 0,9766387

1 CXCR2 NA NA NA NA NA NA NA NA NA 0,62447666 0,9766239

1 CXCR1 NA NA NA NA NA NA NA NA NA 0,3685264 0,9766046

4 NA CYP4F3 TNFRSF10C STEAP4 NA NA NA NA NA NA 0,78765863 0,9765716

7 CXCR2 NA FCGR3B HAL VNN3 TNFRSF10C STEAP4 NA NA NA 0,88916415 0,976548

5 CXCR2 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA NA 0,74243908 0,9764249

5 KCNJ15 FCGR3B CYP4F3 TNFRSF10C STEAP4 NA NA NA NA NA 0,89693428 0,9764215

5 KCNJ15 CXCR2 FCGR3B CXCR1 TNFRSF10C NA NA NA NA NA 0,82284524 0,9763457

5 KCNJ15 CXCR2 CYP4F3 TNFRSF10C STEAP4 NA NA NA NA NA 0,89681976 0,9762898

3 NA FCGR3B STEAP4 NA NA NA NA NA NA NA 0,7438576 0,9762796

6 KCNJ15 NA FCGR3B CXCR1 TNFRSF10C STEAP4 NA NA NA NA 0,82579783 0,9762612

6 KCNJ15 HAL VNN3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA 0,89639591 0,9762187

4 KCNJ15 CXCR2 FCGR3B STEAP4 NA NA NA NA NA NA 0,80832754 0,9762134

3 CXCR2 CYP4F3 TNFRSF10C NA NA NA NA NA NA NA 0,6504626 0,976200

6 CXCR2 FCGR3B HAL CYP4F3 TNFRSF10C STEAP4 NA NA NA NA 0,81350786 0,9761726

6 KCNJ15 NA HAL CXCR1 TNFRSF10C STEAP4 NA NA NA NA 0,87816507 0,9761380

4 FCGR3B HAL CXCR1 TNFRSF10C NA NA NA NA NA NA 0,75523555 0,9759581

6 CXC 2 NA FCGR3B VNN3 TNFRSF10C STEAP4 NA NA NA NA 0,83687077 0,9759325

3 FCGR3B VNN3 STEAP4 NA NA NA NA NA NA NA 0,67360798 0,9758246

4 CXC 2 HAL CXCR1 STEAP4 NA NA NA NA NA NA 0,74963038 0,9758245

4 KCNJ15 NA HAL STEAP4 NA NA NA NA NA NA 0,84747688 0,9757885

4 CXC 2 HAL CXCR1 TNFRSF10C NA NA NA NA NA NA 0,77058895 0,975776

4 FCGR3B HAL CXCR1 STEAP4 NA NA NA NA NA NA 0,74359932 0,9757533

5 KCNJ15 CXCR2 FCGR3B HAL STEAP4 NA NA NA NA NA 0,88945972 0,9757509

6 KCNJ15 CXCR2 NA CXCR1 TNFRSF10C STEAP4 NA NA NA NA 0,82913625 0,9757458

3 CXCR2 VNN3 STEAP4 NA NA NA NA NA NA NA 0,68663342 0,975588

4 CXCR2 NA HAL STEAP4 NA NA NA NA NA NA 0,85714186 0,9755736

4 KCNJ15 NA HAL TNFRSF10C NA NA NA NA NA NA 0,86017116 0,9755687

4 CYP4F3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA NA NA 0,64684575 0,9755619

4 KCNJ15 NA FCGR3B TNFRSF10C NA NA NA NA NA NA 0,80176676 0,9755369

2 KCNJ15 HAL NA NA NA NA NA NA NA NA 0,85328114 0,9755268

3 CXCR2 NA STEAP4 NA NA NA NA NA NA NA 0,76076368 0,9755262

4 CXCR2 NA CXCR1 TNFRSF10C NA NA NA NA NA NA 0,80145351 0,9755213

4 KCNJ15 CXCR2 NA TNFRSF10C NA NA NA NA NA NA 0,80502337 0,9754392

6 CXCR2 FCGR3B VNN3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA 0,74741263 0,9754075

5 KCNJ15 VNN3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA NA 0,83855367 0,9753855

4 CXCR2 FCGR3B VNN3 TNFRSF10C NA NA NA NA NA NA 0,71637199 0,9753577

5 KCNJ15 HAL CYP4F3 TNFRSF10C STEAP4 NA NA NA NA NA 0,89169243 0,9753535

4 KCNJ15 FCGR3B CXCR1 TNFRSF10C NA NA NA NA NA NA 0,80817248 0,975334

6 FCGR3B HAL VNN3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA 0,78293215 0,9753113

4 KCNJ15 HAL VNN3 TNFRSF10C NA NA NA NA NA NA 0,89087843 0,9752994

4 CXCR2 HAL VNN3 TNFRSF10C NA NA NA NA NA NA 0,74936861 0,9752838

6 CXCR2 HAL VNN3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA 0,77994019 0,9752799

6 NA FCGR3B HAL CXCR1 TNFRSF10C STEAP4 NA NA NA NA 0,87592845 0,9752784

7 KCNJ15 CXCR2 FCGR3B HAL CXCR1 TNFRSF10C STEAP4 NA NA NA 0,90554123 0,9752769

4 CXCR2 NA HAL TNFRSF10C NA NA NA NA NA NA 0,88928979 0,975269

6 KCNJ15 NA HAL VNN3 TNFRSF10C STEAP4 NA NA NA NA 0,88977955 0,9752344

5 KCNJ15 NA VNN3 TNFRSF10C STEAP4 NA NA NA NA NA 0,81802029 0,9751643

6 CXC 2 NA HAL CXCR1 TNFRSF10C STEAP4 NA NA NA NA 0,88406469 0,9751134

7 KCNJ15 CXCR2 NA FCGR3B HAL TNFRSF10C STEAP4 NA NA NA 0,91139202 0,9748693

6 CXC 2 NA HAL VNN3 TNFRSF10C STEAP4 NA NA NA NA 0,8768347 0,974846

7 KCNJ15 CXCR2 FCGR3B HAL VNN3 TNFRSF10C STEAP4 NA NA NA 0,91445165 0,974823

4 NA FCGR3B HAL STEAP4 NA NA NA NA NA NA 0,8502935 0,9747461

4 KCNJ15 CYP4F3 TNFRSF10C STEAP4 NA NA NA NA NA NA 0,86094711 0,9746579

3 FCGR3B CXCR1 STEAP4 NA NA NA NA NA NA NA 0,61617696 0,9746485

4 NA FCGR3B HAL TNFRSF10C NA NA NA NA NA NA 0,87403149 0,974610

3 KCNJ15 VNN3 TNFRSF10C NA NA NA NA NA NA NA 0,83065611 0,9746069

5 CXC 2 FCGR3B CYP4F3 TNFRSF10C STEAP4 NA NA NA NA NA 0,77701234 0,9745953

2 CYP4F3 TNFRSF10C NA NA NA NA NA NA NA NA 0,50322931 0,974521

5 KCNJ15 CXCR2 FCGR3B HAL TNFRSF10C NA NA NA NA NA 0,90197643 0,9745147

6 NA FCGR3B HAL VNN3 TNFRSF10C STEAP4 NA NA NA NA 0,87766677 0,9744821

5 CXCR2 HAL CYP4F3 TNFRSF10C STEAP4 NA NA NA NA NA 0,76137505 0,9744684

4 KCNJ15 CXCR2 CXCR1 TNFRSF10C NA NA NA NA NA NA 0,83052695 0,9744426

6 CXCR2 NA FCGR3B CXCR1 TNFRSF10C STEAP4 NA NA NA NA 0,80190407 0,9744032

5 KCNJ15 NA CXCR1 TNFRSF10C STEAP4 NA NA NA NA NA 0,77728984 0,9743920

6 KCNJ15 CXCR2 FCGR3B VNN3 TNFRSF10C STEAP4 NA NA NA NA 0,86106247 0,9742943

5 NA FCGR3B VNN3 TNFRSF10C STEAP4 NA NA NA NA NA 0,82353865 0,9742803

3 NA CXCR1 TNFRSF10C NA NA NA NA NA NA NA 0,69376755 0,9742545

4 KCNJ15 HAL VNN3 STEAP4 NA NA NA NA NA NA 0,86794576 0,9742070

4 FCGR3B HAL VNN3 TNFRSF10C NA NA NA NA NA NA 0,7531681 0,9742015

5 FCGR3B HAL CYP4F3 TNFRSF10C STEAP4 NA NA NA NA NA 0,7820711 0,974094

5 FCGR3B VNN3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA NA 0,7172923 0,9740860

4 CXCR2 HAL VNN3 STEAP4 NA NA NA NA NA NA 0,7374257 0,9740632

5 CXCR2 NA VNN3 TNFRSF10C STEAP4 NA NA NA NA NA 0,83404725 0,973912

6 KCNJ15 CXCR2 NA FCGR3B TNFRSF10C STEAP4 NA NA NA NA 0,83635938 0,9736791

6 KCNJ15 CXCR2 HAL CXCR1 TNFRSFIOC STEAP4 NA NA NA NA 0,91232365 0,9735632

4 CXC 2 NA FCGR3B TNFRSFIOC NA NA NA NA NA NA 0,78232161 0,9735363

6 KCNJ15 FCGR3B HAL CXCR1 TNFRSFIOC STEAP4 NA NA NA NA 0,90039583 0,973394

2 FCGR3B HAL NA NA NA NA NA NA NA NA 0,70238883 0,9733661

6 KCNJ15 CXCR2 FCGR3B CXCR1 TNFRSFIOC STEAP4 NA NA NA NA 0,82979211 0,9732789

6 KCNJ15 CXCR2 NA HAL TNFRSFIOC STEAP4 NA NA NA NA 0,901941 0,9730772

5 CXC 2 VNN3 CXCR1 TNFRSFIOC STEAP4 NA NA NA NA NA 0,72930411 0,9730731

3 FCGR3B VNN3 TNFRSF10C NA NA NA NA NA NA NA 0,68370508 0,9730588

5 NA FCGR3B CXCR1 TNFRSFIOC STEAP4 NA NA NA NA NA 0,7787785 0,9730320

3 KCNJ15 CXCR2 STEAP4 NA NA NA NA NA NA NA 0,79716548 0,9730153

3 HAL CXCR1 TNFRSF10C NA NA NA NA NA NA NA 0,64807884 0,9729834

5 NA HAL CXCR1 TNFRSFIOC STEAP4 NA NA NA NA NA 0,82407018 0,9728717

6 KCNJ15 CXCR2 HAL VNN3 TNFRSFIOC STEAP4 NA NA NA NA 0,9159039 0,9728333

4 FCGR3B CYP4F3 TNFRSF10C STEAP4 NA NA NA NA NA NA 0,74434827 0,9728262

3 KCNJ15 NA TNFRSF10C NA NA NA NA NA NA NA 0,73775064 0,9727919

4 FCGR3B HAL VNN3 STEAP4 NA NA NA NA NA NA 0,74461991 0,9727595

4 KCNJ15 CXCR2 HAL STEAP4 NA NA NA NA NA NA 0,88954572 0,9727167

5 HAL VNN3 CXCR1 TNFRSFIOC STEAP4 NA NA NA NA NA 0,69613868 0,9726068

6 KCNJ15 NA FCGR3B HAL TNFRSFIOC STEAP4 NA NA NA NA 0,89918408 0,9725542

3 KCNJ15 FCGR3B STEAP4 NA NA NA NA NA NA NA 0,78296027 0,9724871

3 CXCR2 VNN3 TNFRSF10C NA NA NA NA NA NA NA 0,71801953 0,9724360

3 CXCR2 CXCR1 STEAP4 NA NA NA NA NA NA NA 0,63860637 0,9723458

3 KCNJ15 CXCR1 TNFRSF10C NA NA NA NA NA NA NA 0,77228388 0,972301

4 CXCR2 CYP4F3 TNFRSF10C STEAP4 NA NA NA NA NA NA 0,72650148 0,9722332

4 KCNJ15 CXCR2 HAL TNFRSFIOC NA NA NA NA NA NA 0,91607502 0,9721753

6 KCNJ15 FCGR3B HAL VNN3 TNFRSFIOC STEAP4 NA NA NA NA 0,90936965 0,9721221

5 KCNJ15 CXCR2 VNN3 TNFRSFIOC STEAP4 NA NA NA NA NA 0,86389529 0,9720225

5 CXCR2 NA CXCR1 TNFRSFIOC STEAP4 NA NA NA NA NA 0,7942375 0,9719448

6 CXCR2 FCGR3B HAL CXCR1 TNFRSFIOC STEAP4 NA NA NA NA 0,79507831 0,971908

5 KCNJ15 FCGR3B VNN3 TNFRSF10C STEAP4 NA NA NA NA NA 0,85134355 0,971856

6 CXC 2 NA FCGR3B HAL TNFRSFIOC STEAP4 NA NA NA NA 0,87759702 0,9716781

4 CXC 2 FCGR3B CXCR1 TNFRSF10C NA NA NA NA NA NA 0,66757757 0,9715825

5 NA HAL VNN3 TNFRSF10C STEAP4 NA NA NA NA NA 0,81714064 0,9715620

5 KCNJ15 NA FCGR3B TNFRSF10C STEAP4 NA NA NA NA NA 0,81227385 0,9714419

5 KCNJ15 CXCR2 NA TNFRSF10C STEAP4 NA NA NA NA NA 0,81417711 0,9714161

5 KCNJ15 FCGR3B CXCR1 TNFRSFIOC STEAP4 NA NA NA NA NA 0,81294445 0,9713664

6 CXC 2 FCGR3B HAL VNN3 TNFRSFIOC STEAP4 NA NA NA NA 0,79982958 0,9713128

4 KCNJ15 CXCR2 FCGR3B TNFRSFIOC NA NA NA NA NA NA 0,81427801 0,971277

4 KCNJ15 FCGR3B HAL STEAP4 NA NA NA NA NA NA 0,87822392 0,9712138

4 HAL CYP4F3 TNFRSF10C STEAP4 NA NA NA NA NA NA 0,6783907 0,9710592

3 NA HAL TNFRSF10C NA NA NA NA NA NA NA 0,81101126 0,970900

3 NA FCGR3B TNFRSF10C NA NA NA NA NA NA NA 0,75899876 0,9708990

4 NA VNN3 TNFRSF10C STEAP4 NA NA NA NA NA NA 0,75723381 0,9708652

4 KCNJ15 FCGR3B HAL TNFRSFIOC NA NA NA NA NA NA 0,8986973 0,9707858

5 KCNJ15 CXCR2 CXCR1 TNFRSFIOC STEAP4 NA NA NA NA NA 0,82751428 0,9707800

5 KCNJ15 HAL CXCR1 TNFRSFIOC STEAP4 NA NA NA NA NA 0,87864833 0,9706382

4 VNN3 CXCR1 TNFRSF10C STEAP4 NA NA NA NA NA NA 0,61656151 0,9703787

3 HAL CXCR1 STEAP4 NA NA NA NA NA NA NA 0,62654984 0,970195

4 CXC 2 FCGR3B HAL STEAP4 NA NA NA NA NA NA 0,76256034 0,9701621

3 CXCR2 NA TNFRSF10C NA NA NA NA NA NA NA 0,79285885 0,969938

5 CXCR2 FCGR3B VNN3 TNFRSFIOC STEAP4 NA NA NA NA NA 0,73605899 0,9698885

6 KCNJ15 CXCR2 FCGR3B HAL TNFRSFIOC STEAP4 NA NA NA NA 0,89794709 0,9695784

5 KCNJ15 NA HAL TNFRSFIOC STEAP4 NA NA NA NA NA 0,8624141 0,9695746

4 CXCR2 FCGR3B HAL TNFRSFIOC NA NA NA NA NA NA 0,77414733 0,9695693

3 HAL VNN3 TNFRSF10C NA NA NA NA NA NA NA 0,63048085 0,969415

5 CXCR2 NA FCGR3B TNFRSFIOC STEAP4 NA NA NA NA NA 0,78987124 0,9693398

4 NA CXCR1 TNFRSF10C STEAP4 NA NA NA NA NA NA 0,69952027 0,9692769

2 NA STEAP4 NA NA NA NA NA NA NA NA 0,62151689 0,9692586

3 CXC 2 FCGR3B STEAP4 NA NA NA NA NA NA NA 0,65186583 0,9690371

3 FCGR3B CXCR1 TNFRSF10C NA NA NA NA NA NA NA 0,61454421 0,9689868

3 NA HAL STEAP4 NA NA NA NA NA NA NA 0,77042069 0,9689823

3 CYP4F3 TNFRSF10C STEAP4 NA NA NA NA NA NA NA 0,61733804 0,9688207

5 CXC 2 HAL CXCR1 TNFRSFIOC STEAP4 NA NA NA NA NA 0,77357948 0,9686718

5 KCNJ15 HAL VNN3 TNFRSFIOC STEAP4 NA NA NA NA NA 0,88306856 0,9686673

5 FCGR3B HAL CXCR1 TNFRSFIOC STEAP4 NA NA NA NA NA 0,76711329 0,9686480

5 CXCR2 NA HAL TNFRSFIOC STEAP4 NA NA NA NA NA 0,8707226 0,9684584

5 CXCR2 FCGR3B CXCR1 TNFRSFIOC STEAP4 NA NA NA NA NA 0,69568067 0,9680724

5 NA FCGR3B HAL TNFRSFIOC STEAP4 NA NA NA NA NA 0,86418381 0,9678630

4 KCNJ15 VNN3 TNFRSF10C STEAP4 NA NA NA NA NA NA 0,82010903 0,9678303

4 KCNJ15 NA TNFRSFIOC STEAP4 NA NA NA NA NA NA 0,75575579 0,9676694

5 CXCR2 HAL VNN3 TNFRSFIOC STEAP4 NA NA NA NA NA 0,76485234 0,9676067

4 KCNJ15 CXCR1 TNFRSFIOC STEAP4 NA NA NA NA NA NA 0,77285509 0,9674030

5 KCNJ15 CXCR2 FCGR3B TNFRSFIOC STEAP4 NA NA NA NA NA 0,81866673 0,9673485

3 KCNJ15 CXCR2 TNFRSFIOC NA NA NA NA NA NA NA 0,81736713 0,9671918

3 KCNJ15 FCGR3B TNFRSFIOC NA NA NA NA NA NA NA 0,79542787 0,9667539

5 FCGR3B HAL VNN3 TNFRSFIOC STEAP4 NA NA NA NA NA 0,76980288 0,9667014

2 VNN3 TNFRSF10C NA NA NA NA NA NA NA NA 0,55919657 0,9664583

3 CXCR2 CXCR1 TNFRSFIOC NA NA NA NA NA NA NA 0,66471352 0,966320

5 KCNJ15 CXCR2 HAL TNFRSFIOC STEAP4 NA NA NA NA NA 0,90046167 0,9659237

2 VNN3 STEAP4 NA NA NA NA NA NA NA NA 0,51514046 0,965758

3 KCNJ15 HAL TNFRSFIOC NA NA NA NA NA NA NA 0,8762787 0,9655469

4 FCGR3B VNN3 TNFRSFIOC STEAP4 NA NA NA NA NA NA 0,69956156 0,9651412

4 NA FCGR3B TNFRSFIOC STEAP4 NA NA NA NA NA NA 0,76001236 0,9651396

4 CXCR2 VNN3 TNFRSFIOC STEAP4 NA NA NA NA NA NA 0,71016279 0,9649816

5 KCNJ15 FCGR3B HAL TNFRSFIOC STEAP4 NA NA NA NA NA 0,88960578 0,9648213

2 CXCR1 STEAP4 NA NA NA NA NA NA NA NA 0,42370895 0,9647688

4 CXCR2 NA TNFRSFIOC STEAP4 NA NA NA NA NA NA 0,77319957 0,9646773

3 HAL VNN3 STEAP4 NA NA NA NA NA NA NA 0,62279691 0,9645898

3 KCNJ15 HAL STEAP4 NA NA NA NA NA NA NA 0,8410868 0,9641931

4 FCG 3B CXCR1 TNFRSFIOC STEAP4 NA NA NA NA NA NA 0,64564148 0,9639988

3 CXC 2 HAL TNFRSFIOC NA NA NA NA NA NA NA 0,75802434 0,963834

2 KCNJ15 STEAP4 NA NA NA NA NA NA NA NA 0,72129633 0,9637747

2 NA TNFRSF10C NA NA NA NA NA NA NA NA 0,66022453 0,9634528

4 HAL CXCR1 TNFRSFIOC STEAP4 NA NA NA NA NA NA 0,67289003 0,9629309

5 CXC 2 FCGR3B HAL TNFRSFIOC STEAP4 NA NA NA NA NA 0,78304262 0,9629057

4 CXC 2 CXCR1 TNFRSFIOC STEAP4 NA NA NA NA NA NA 0,66275689 0,9625009

3 CXCR2 HAL STEAP4 NA NA NA NA NA NA NA 0,7200711 0,9623386

4 KCNJ15 CXCR2 TNFRSFIOC STEAP4 NA NA NA NA NA NA 0,81007088 0,9623089

4 NA HAL TNFRSFIOC STEAP4 NA NA NA NA NA NA 0,79901982 0,9619917

4 KCNJ15 FCGR3B TNFRSFIOC STEAP4 NA NA NA NA NA NA 0,79714284 0,9619051

3 FCGR3B HAL TNFRSFIOC NA NA NA NA NA NA NA 0,74245329 0,9616084

3 CXCR2 FCGR3B TNFRSFIOC NA NA NA NA NA NA NA 0,65310781 0,961574

3 FCGR3B HAL STEAP4 NA NA NA NA NA NA NA 0,71835032 0,9597670

4 HAL VNN3 TNFRSFIOC STEAP4 NA NA NA NA NA NA 0,6689673 0,9595470

2 CXCR1 TNFRSFIOC NA NA NA NA NA NA NA NA 0,44896197 0,9585397

4 KCNJ15 HAL TNFRSFIOC STEAP4 NA NA NA NA NA NA 0,85976787 0,9580495

4 CXCR2 FCGR3B TNFRSFIOC STEAP4 NA NA NA NA NA NA 0,67718598 0,95728

2 KCNJ15 TNFRSFIOC NA NA NA NA NA NA NA NA 0,74727494 0,9571378

2 CXCR2 STEAP4 NA NA NA NA NA NA NA NA 0,58931625 0,9565227

2 FCGR3B STEAP4 NA NA NA NA NA NA NA NA 0,57601257 0,9564330

3 NA TNFRSFIOC STEAP4 NA NA NA NA NA NA NA 0,6586713 0,9561639

4 CXCR2 HAL TNFRSFIOC STEAP4 NA NA NA NA NA NA 0,75223003 0,9551150

3 VNN3 TNFRSFIOC STEAP4 NA NA NA NA NA NA NA 0,57425548 0,9548486

3 CXCR1 TNFRSFIOC STEAP4 NA NA NA NA NA NA NA 0,49495687 0,9535749

4 FCGR3B HAL TNFRSFIOC STEAP4 NA NA NA NA NA NA 0,74841561 0,9534373

3 KCNJ15 TNFRSFIOC STEAP4 NA NA NA NA NA NA NA 0,74520811 0,9517838

1 HAL NA NA NA NA NA NA NA NA NA 0,52091783 0,950759

2 FCG 3B TNFRSFIOC NA NA NA NA NA NA NA NA 0,59015901 0,9468673

2 CXC 2 TNFRSFIOC NA NA NA NA NA NA NA NA 0,65147504 0,9464135

2 HAL TNFRSFIOC NA NA NA NA NA NA NA NA 0,61103242 0,9447904

3 CXC 2 TNFRSFIOC STEAP4 NA NA NA NA NA NA NA 0,62828006 0,9434731

3 FCGR3B TNFRSFIOC STEAP4 NA NA NA NA NA NA NA 0,61578023 0,9432000

2 HAL STEAP4 NA NA NA NA NA NA NA NA 0,57460017 0,9362668

3 HAL TNFRSFIOC STEAP4 NA NA NA NA NA NA NA 0,63361718 0,9361028

2 TNFRSF10C STEAP4 NA NA NA NA NA NA NA NA 0,42311976 0,9027251

1 STEAP4 NA NA NA NA NA NA NA NA NA 0,32180583 0,8877205

1 TNFRSFIOC NA NA NA NA NA NA NA NA NA 0,36301142 0,8699708

Combination of genes for identification of NK cells

Figure imgf000183_0001

Figure imgf000184_0001

Figure imgf000185_0001

Figure imgf000186_0001

Figure imgf000187_0001

Figure imgf000188_0001

Figure imgf000189_0001

Figure imgf000190_0001

Figure imgf000191_0001

Figure imgf000192_0001

Figure imgf000193_0001

Figure imgf000194_0001

Figure imgf000195_0001

Figure imgf000196_0001

Figure imgf000197_0001

Figure imgf000198_0001

Figure imgf000199_0001

Figure imgf000200_0001

Figure imgf000201_0001

Figure imgf000202_0001

Figure imgf000203_0001

Figure imgf000204_0001

Figure imgf000205_0001

Figure imgf000206_0001

Figure imgf000207_0001

Figure imgf000208_0001

Figure imgf000209_0001

Figure imgf000210_0001

Figure imgf000211_0001

Figure imgf000212_0001

Figure imgf000213_0001

Figure imgf000214_0001

Figure imgf000215_0001

Figure imgf000216_0001

Figure imgf000217_0001

Figure imgf000218_0001

Figure imgf000219_0001

Figure imgf000220_0001

Figure imgf000221_0001

Figure imgf000222_0001

Figure imgf000223_0001

Figure imgf000224_0001

Figure imgf000225_0001

Figure imgf000226_0001

Figure imgf000227_0001

Figure imgf000228_0001

Figure imgf000229_0001

Figure imgf000230_0001

Figure imgf000231_0001

Figure imgf000232_0001

Figure imgf000233_0001

Figure imgf000234_0001

Figure imgf000235_0001

Figure imgf000236_0001

Figure imgf000237_0001

Figure imgf000238_0001

Figure imgf000239_0001

Figure imgf000240_0001

Figure imgf000241_0001

Figure imgf000242_0001

Figure imgf000243_0001

Figure imgf000244_0001

Figure imgf000245_0001

Figure imgf000246_0001

Combination of genes for identification of T cells

4 TRAT1 SIRPG ICOS CD28 NA NA NA NA NA NA 0,8798215 0,9973887

2 TRAT1 CD28 NA NA NA NA NA NA NA NA 0,79861814 0,9972424

3 TRAT1 SIRPG CD28 NA NA NA NA NA NA NA 0,86632136 0,9972358

3 TRAT1 CD6 CD28 NA NA NA NA NA NA NA 0,88277553 0,9968704

4 CD3D TRAT1 ICOS CD28 NA NA NA NA NA NA 0,89191247 0,9966120

4 T AT1 CD3G ICOS CD28 NA NA NA NA NA NA 0,88327837 0,996573

5 TRAT1 SIRPG ICOS CTLA4 CD28 NA NA NA NA NA 0,8836644 0,9964347

5 TRAT1 SIRPG ICOS CD6 CD28 NA NA NA NA NA 0,91386967 0,9964100

3 TRAT1 ICOS CD28 NA NA NA NA NA NA NA 0,84244075 0,9960562

4 TRAT1 SIRPG CD6 CD28 NA NA NA NA NA NA 0,91009568 0,9960111

5 CD3D TRAT1 SIRPG ICOS CD28 NA NA NA NA NA 0,90542062 0,9959950

4 TRAT1 SIRPG CTLA4 CD28 NA NA NA NA NA NA 0,880905 0,9959547

4 TRAT1 ICOS CD6 CD28 NA NA NA NA NA NA 0,89738039 0,9959539

5 TRAT1 CD3G ICOS CTLA4 CD28 NA NA NA NA NA 0,88749215 0,9957201

6 TRAT1 SIRPG ICOS CD6 CTLA4 CD28 NA NA NA NA 0,91213091 0,9957111

5 CD3D TRAT1 ICOS CD6 CD28 NA NA NA NA NA 0,91312836 0,9956300

6 CD3D TRAT1 SIRPG ICOS CTLA4 CD28 NA NA NA NA 0,90701484 0,9954621

5 CD3D TRAT1 ICOS CTLA4 CD28 NA NA NA NA NA 0,89440382 0,9954251

5 TRAT1 CD3G ICOS CD6 CD28 NA NA NA NA NA 0,91212158 0,9954025

4 TRAT1 SIRPG THEMIS CD28 NA NA NA NA NA NA 0,87386529 0,9952820

6 TRAT1 SIRPG CD3G ICOS THEMIS CD28 NA NA NA NA 0,90306128 0,9952589

5 TRAT1 SIRPG CD6 CTLA4 CD28 NA NA NA NA NA 0,91434605 0,9951460

3 CD3D TRAT1 ICOS NA NA NA NA NA NA NA 0,89363942 0,9951440

4 TRAT1 ICOS CTLA4 CD28 NA NA NA NA NA NA 0,85522959 0,9950971

6 TRAT1 SIRPG CD3G ICOS CTLA4 CD28 NA NA NA NA 0,90341823 0,9950481

5 TRAT1 CD3G ICOS THEMIS CD28 NA NA NA NA NA 0,88658294 0,9950304

5 TRAT1 SIRPG CD3G ICOS CD28 NA NA NA NA NA 0,90127003 0,9950080

5 TRAT1 ICOS CD6 CTLA4 CD28 NA NA NA NA NA 0,89637189 0,994974

7 TRAT1 SIRPG CD3G ICOS THEMIS CTLA4 CD28 NA NA NA 0,90699669 0,9949712

3 TRAT1 CTLA4 CD28 NA NA NA NA NA NA NA 0,84058339 0,9949706

6 CD3D TRAT1 SIRPG ICOS CD6 CD28 NA NA NA NA 0,92087181 0,9949358

4 TRAT1 CD6 CTLA4 CD28 NA NA NA NA NA NA 0,89366921 0,9948833

6 TRAT1 CD3G ICOS CD6 CTLA4 CD28 NA NA NA NA 0,91244318 0,9948810

4 T AT1 CD3G THEMIS CD28 NA NA NA NA NA NA 0,8691429 0,9948704

6 CD3D TRAT1 SIRPG ICOS THEMIS CD28 NA NA NA NA 0,908657 0,9948517

6 CD3D TRAT1 ICOS CD6 CTLA4 CD28 NA NA NA NA 0,91393984 0,994778

3 TRAT1 SIRPG ICOS NA NA NA NA NA NA NA 0,88141023 0,9947645

5 TRAT1 SIRPG CD6 THEMIS CD28 NA NA NA NA NA 0,90973013 0,994727

7 CD3D TRAT1 SIRPG ICOS CD6 CTLA4 CD28 NA NA NA 0,9218713 0,9946517

5 CD3D TRAT1 SIRPG THEMIS CD28 NA NA NA NA NA 0,90487829 0,9946442

5 TRAT1 SIRPG THEMIS CTLA4 CD28 NA NA NA NA NA 0,8884824 0,9946105

1 TRAT1 NA NA NA NA NA NA NA NA NA 0,81700729 0,9946045

3 TRAT1 SIRPG THEMIS NA NA NA NA NA NA NA 0,87728197 0,994576

6 TRAT1 CD3G ICOS THEMIS CTLA4 CD28 NA NA NA NA 0,89322564 0,994553

6 TRAT1 SIRPG ICOS THEMIS CD5 CD28 NA NA NA NA 0,91095415 0,9945475

7 CD3D TRAT1 SIRPG ICOS THEMIS CTLA4 CD28 NA NA NA 0,91119851 0,9945154

5 TRAT1 SIRPG CD3G THEMIS CD28 NA NA NA NA NA 0,89408053 0,9945083

5 TRAT1 ICOS CD6 CD5 CD28 NA NA NA NA NA 0,91425353 0,9945057

7 TRAT1 SIRPG CD3G ICOS CD6 THEMIS CD28 NA NA NA 0,92181882 0,9944678

6 TRAT1 CD3G ICOS CD6 THEMIS CD28 NA NA NA NA 0,91222378 0,9944183

4 TRAT1 SIRPG ICOS CTLA4 NA NA NA NA NA NA 0,88410996 0,9943663

4 TRAT1 ICOS CD5 CD28 NA NA NA NA NA NA 0,88886777 0,9943460

3 CD3D TRAT1 CD28 NA NA NA NA NA NA NA 0,88475957 0,9943317

8 TRAT1 SIRPG CD3G ICOS CD6 THEMIS CTLA4 CD28 NA NA 0,9236679 0,9943254

6 TRAT1 SIRPG CD3G THEMIS CTLA4 CD28 NA NA NA NA 0,90467274 0,9942879

7 TRAT1 SIRPG ICOS CD6 THEMIS CD5 CD28 NA NA NA 0,92733425 0,99426

7 CD3D TRAT1 SIRPG ICOS CD6 THEMIS CD28 NA NA NA 0,92345385 0,9942276

7 TRAT1 SIRPG CD3G ICOS CD6 CTLA4 CD28 NA NA NA 0,92179748 0,9942107

5 TRAT1 SIRPG ICOS THEMIS CD28 NA NA NA NA NA 0,88721206 0,9942058

6 TRAT1 SIRPG CD6 THEMIS CTLA4 CD28 NA NA NA NA 0,91627342 0,9941990

6 CD3D TRAT1 SIRPG THEMIS CTLA4 CD28 NA NA NA NA 0,91153386 0,9941677

7 TRAT1 SIRPG ICOS THEMIS CTLA4 CD5 CD28 NA NA NA 0,91282286 0,9941605

5 T AT1 CD3G THEMIS CTLA4 CD28 NA NA NA NA NA 0,88669521 0,9941575

6 TRAT1 SIRPG ICOS THEMIS CTLA4 CD28 NA NA NA NA 0,89255223 0,9941038

6 CD3D TRAT1 CD3G ICOS THEMIS CD28 NA NA NA NA 0,90523464 0,994085

5 TRAT1 CD3G CD6 THEMIS CD28 NA NA NA NA NA 0,9019252 0,9940787

7 TRAT1 CD3G ICOS CD6 THEMIS CTLA4 CD28 NA NA NA 0,91492627 0,9940761

6 TRAT1 SIRPG CD3G ICOS CD6 CD28 NA NA NA NA 0,92126262 0,9940166

4 SIRPG ICOS CTLA4 CD28 NA NA NA NA NA NA 0,87008023 0,9940163

8 CD3D TRAT1 SIRPG ICOS CD6 THEMIS CTLA4 CD28 NA NA 0,9249025 0,9940104

6 TRAT1 SIRPG ICOS CD6 THEMIS CD28 NA NA NA NA 0,91568695 0,993986

4 CD3D TRAT1 THEMIS CD28 NA NA NA NA NA NA 0,88771712 0,9939429

6 TRAT1 ICOS CD6 THEMIS CD5 CD28 NA NA NA NA 0,91843162 0,9939421

8 TRAT1 SIRPG ICOS CD6 THEMIS CTLA4 CD5 CD28 NA NA 0,92809142 0,9939235

2 TRAT1 ICOS NA NA NA NA NA NA NA NA 0,85332591 0,9938715

7 TRAT1 SIRPG ICOS CD6 THEMIS CTLA4 CD28 NA NA NA 0,91639175 0,9938

6 CD3D TRAT1 SIRPG CD6 THEMIS CD28 NA NA NA NA 0,92131375 0,9938619

7 CD3D TRAT1 CD3G ICOS THEMIS CTLA4 CD28 NA NA NA 0,90939501 0,9938559

5 TRAT1 ICOS THEMIS CD5 CD28 NA NA NA NA NA 0,89544172 0,9938555

5 CD3D TRAT1 SIRPG ICOS THEMIS NA NA NA NA NA 0,90935609 0,9938476

4 TRAT1 CD3G ICOS THEMIS NA NA NA NA NA NA 0,89124304 0,9938417

6 TRAT1 ICOS CD6 CTLA4 CD5 CD28 NA NA NA NA 0,91421281 0,9938308

5 TRAT1 SIRPG ICOS CD5 CD28 NA NA NA NA NA 0,90655404 0,9938243

8 CD3D TRAT1 SIRPG CD3G ICOS THEMIS CTLA4 CD28 NA NA 0,91725029 0,9938184

6 TRAT1 SIRPG ICOS CTLA4 CD5 CD28 NA NA NA NA 0,90702869 0,9937959

7 CD3D TRAT1 SIRPG CD3G ICOS THEMIS CD28 NA NA NA 0,91396759 0,9937683

5 CD3D TRAT1 ICOS THEMIS CD28 NA NA NA NA NA 0,89619764 0,9937564

5 TRAT1 ICOS CTLA4 CD5 CD28 NA NA NA NA NA 0,89069669 0,9937477

4 CD3D TRAT1 CD6 CD28 NA NA NA NA NA NA 0,90912077 0,9936913

6 TRAT1 SIRPG ICOS CD6 CD5 CD28 NA NA NA NA 0,92356614 0,9936782

3 CD3D TRAT1 THEMIS NA NA NA NA NA NA NA 0,89130327 0,9936561

4 CD3D TRAT1 ICOS CTLA4 NA NA NA NA NA NA 0,8958562 0,9936431

6 T AT1 SIRPG CD3G CD6 THEMIS CD28 NA NA NA NA 0,9164043 0,9936248

6 TRAT1 CD3G CD6 THEMIS CTLA4 CD28 NA NA NA NA 0,91212583 0,9936067

7 TRAT1 SIRPG ICOS CD6 CTLA4 CD5 CD28 NA NA NA 0,92388926 0,9936015

7 TRAT1 SIRPG CD3G CD6 THEMIS CTLA4 CD28 NA NA NA 0,92329998 0,9935875

7 CD3D TRAT1 SIRPG CD6 THEMIS CTLA4 CD28 NA NA NA 0,92618153 0,9935801

4 CD3D TRAT1 CTLA4 CD28 NA NA NA NA NA NA 0,89398087 0,9935567

5 CD3D TRAT1 CD6 THEMIS CD28 NA NA NA NA NA 0,91076254 0,993535

5 SIRPG ICOS CD6 CTLA4 CD28 NA NA NA NA NA 0,90645411 0,993522

6 CD3D TRAT1 ICOS CD6 THEMIS CD28 NA NA NA NA 0,91574636 0,9935138

6 CD3D TRAT1 SIRPG ICOS THEMIS CTLA4 NA NA NA NA 0,91282441 0,9935022

4 TRAT1 SIRPG THEMIS CTLA4 NA NA NA NA NA NA 0,89397388 0,9934830

6 TRAT1 SIRPG CD3G ICOS THEMIS CTLA4 NA NA NA NA 0,90936742 0,9934775

6 CD3D TRAT1 ICOS THEMIS CTLA4 CD28 NA NA NA NA 0,9001827 0,9934682

5 TRAT1 SIRPG CD3G ICOS THEMIS NA NA NA NA NA 0,90450633 0,9934585

7 TRAT1 ICOS CD6 THEMIS CTLA4 CD5 CD28 NA NA NA 0,91964725 0,9934354

3 SIRPG ICOS CD28 NA NA NA NA NA NA NA 0,86450947 0,9934192

7 CD3D TRAT1 CD3G ICOS CD6 THEMIS CD28 NA NA NA 0,91901498 0,9933994

5 TRAT1 SIRPG THEMIS CD5 CD28 NA NA NA NA NA 0,90434273 0,9933759

6 TRAT1 ICOS THEMIS CTLA4 CD5 CD28 NA NA NA NA 0,89937189 0,9933757

5 CD3D TRAT1 SIRPG CTLA4 CD28 NA NA NA NA NA 0,90926298 0,9933588

5 TRAT1 CD3G ICOS THEMIS CTLA4 NA NA NA NA NA 0,89750338 0,9933240

8 CD3D TRAT1 CD3G ICOS CD6 THEMIS CTLA4 CD28 NA NA 0,92214483 0,9933057

4 CD3G ICOS CTLA4 CD28 NA NA NA NA NA NA 0,87502843 0,9932976

5 CD3D TRAT1 THEMIS CTLA4 CD28 NA NA NA NA NA 0,89801934 0,9932842

6 CD3D TRAT1 CD3G ICOS CTLA4 CD28 NA NA NA NA 0,90632181 0,9932802

7 CD3D TRAT1 ICOS CD6 THEMIS CTLA4 CD28 NA NA NA 0,91761233 0,9932595

6 TRAT1 SIRPG CD6 THEMIS CD5 CD28 NA NA NA NA 0,92322751 0,9932375

5 TRAT1 CD6 THEMIS CD5 CD28 NA NA NA NA NA 0,90942534 0,9932313

5 T AT1 SIRPG ICOS THEMIS CD5 NA NA NA NA NA 0,9134268 0,9932272

9 CD3D TRAT1 SIRPG CD3G ICOS CD6 THEMIS CTLA4 CD28 NA 0,92758745 0,9932131

7 CD3D TRAT1 SIRPG ICOS THEMIS CD5 CD28 NA NA NA 0,92108371 0,9932002

5 TRAT1 SIRPG ICOS CD6 CTLA4 NA NA NA NA NA 0,91302684 0,993186

4 CD3D TRAT1 SIRPG THEMIS NA NA NA NA NA NA 0,90538525 0,9931790

5 CD3D TRAT1 CD6 CTLA4 CD28 NA NA NA NA NA 0,91536266 0,9931455

8 CD3D TRAT1 SIRPG ICOS THEMIS CTLA4 CD5 CD28 NA NA 0,92294698 0,9931429

6 CD3D TRAT1 ICOS THEMIS CD5 CD28 NA NA NA NA 0,91351623 0,9931348

5 CD3D SIRPG ICOS CTLA4 CD28 NA NA NA NA NA 0,90248236 0,9931282

4 SIRPG ICOS CD6 CD28 NA NA NA NA NA NA 0,90918898 0,9931220

6 TRAT1 SIRPG THEMIS CTLA4 CD5 CD28 NA NA NA NA 0,91245898 0,9931188

4 CD3D TRAT1 ICOS THEMIS NA NA NA NA NA NA 0,89965015 0,9930970

5 CD3D TRAT1 SIRPG ICOS CTLA4 NA NA NA NA NA 0,90638977 0,9930634

8 CD3D TRAT1 SIRPG CD3G ICOS CD6 THEMIS CD28 NA NA 0,92484855 0,9930608

3 TRAT1 CD3G THEMIS NA NA NA NA NA NA NA 0,87112694 0,9930297

4 TRAT1 SIRPG ICOS CD6 NA NA NA NA NA NA 0,91393985 0,9930277

4 TRAT1 ICOS THEMIS CD5 NA NA NA NA NA NA 0,9028124 0,9930240

4 CD3D TRAT1 SIRPG CD28 NA NA NA NA NA NA 0,90349588 0,9930191

6 CD3D TRAT1 CD6 THEMIS CTLA4 CD28 NA NA NA NA 0,91742329 0,9930171

4 TRAT1 CD6 THEMIS CD28 NA NA NA NA NA NA 0,88635832 0,9930167

7 CD3D TRAT1 ICOS CD6 THEMIS CD5 CD28 NA NA NA 0,92489681 0,9930090

6 TRAT1 CD3G ICOS THEMIS CD5 CD28 NA NA NA NA 0,90929404 0,9930001

3 TRAT1 ICOS CD6 NA NA NA NA NA NA NA 0,90700861 0,9929946

7 TRAT1 SIRPG CD6 THEMIS CTLA4 CD5 CD28 NA NA NA 0,92903244 0,9929891

4 TRAT1 SIRPG CD6 THEMIS NA NA NA NA NA NA 0,91289021 0,9929588

5 CD3D TRAT1 CD3G ICOS CD28 NA NA NA NA NA 0,90295801 0,9929416

7 TRAT1 CD3G ICOS THEMIS CTLA4 CD5 CD28 NA NA NA 0,91258648 0,9929317

6 SIRPG CD3G ICOS THEMIS CTLA4 CD28 NA NA NA NA 0,90669487 0,9929264

5 TRAT1 SIRPG ICOS THEMIS CTLA4 NA NA NA NA NA 0,89599899 0,9929190

3 T AT1 ICOS CTLA4 NA NA NA NA NA NA NA 0,85683535 0,9929184

4 TRAT1 THEMIS CD5 CD28 NA NA NA NA NA NA 0,88033536 0,9929112

8 CD3D TRAT1 SIRPG ICOS CD6 THEMIS CD5 CD28 NA NA 0,92997957 0,9929055

6 TRAT1 SIRPG ICOS THEMIS CTLA4 CD5 NA NA NA NA 0,91577159 0,9928916

4 TRAT1 CD3G CTLA4 CD28 NA NA NA NA NA NA 0,88189754 0,9928833

4 TRAT1 SIRPG ICOS THEMIS NA NA NA NA NA NA 0,89120149 0,9928831

9 CD3D TRAT1 SIRPG ICOS CD6 THEMIS CTLA4 CD5 CD28 NA 0,9319578 0,9928791

7 CD3D TRAT1 ICOS THEMIS CTLA4 CD5 CD28 NA NA NA 0,91574756 0,9928708

4 CD3D TRAT1 ICOS CD6 NA NA NA NA NA NA 0,91140118 0,9928531

8 TRAT1 SIRPG CD3G ICOS THEMIS CTLA4 CD5 CD28 NA NA 0,9212912 0,9928508

5 SIRPG CD3G ICOS CTLA4 CD28 NA NA NA NA NA 0,89773294 0,9928359

7 TRAT1 CD3G ICOS CD6 THEMIS CD5 CD28 NA NA NA 0,9238924 0,992806

8 CD3D TRAT1 ICOS CD6 THEMIS CTLA4 CD5 CD28 NA NA 0,92698392 0,9927636

4 CD3D TRAT1 SIRPG ICOS NA NA NA NA NA NA 0,9027907 0,9927469

8 TRAT1 CD3G ICOS CD6 THEMIS CTLA4 CD5 CD28 NA NA 0,92634885 0,9927466

6 CD3D TRAT1 SIRPG CD6 CTLA4 CD28 NA NA NA NA 0,92466112 0,9927427

5 TRAT1 ICOS CD6 THEMIS CD5 NA NA NA NA NA 0,92201329 0,9927240

5 CD3D TRAT1 SIRPG THEMIS CTLA4 NA NA NA NA NA 0,91426331 0,9927134

6 CD3D TRAT1 SIRPG ICOS CD6 THEMIS NA NA NA NA 0,92283391 0,992671

7 CD3D TRAT1 CD3G ICOS CD6 CTLA4 CD28 NA NA NA 0,91976658 0,9926577

5 TRAT1 CD6 THEMIS CTLA4 CD28 NA NA NA NA NA 0,89902428 0,9926493

7 CD3D TRAT1 SIRPG ICOS CD6 THEMIS CTLA4 NA NA NA 0,92574491 0,9926422

6 TRAT1 CD6 THEMIS CTLA4 CD5 CD28 NA NA NA NA 0,91828556 0,992638

7 TRAT1 SIRPG CD3G ICOS THEMIS CD5 CD28 NA NA NA 0,91884042 0,992635

6 TRAT1 SIRPG ICOS CD6 THEMIS CD5 NA NA NA NA 0,92728591 0,9926334

3 CD3G ICOS CD28 NA NA NA NA NA NA NA 0,86817411 0,9926235

5 CD3G ICOS CD6 CTLA4 CD28 NA NA NA NA NA 0,90608797 0,9925806

9 TRAT1 SIRPG CD3G ICOS CD6 THEMIS CTLA4 CD5 CD28 NA 0,93209436 0,9925702

5 TRAT1 CD3G ICOS CD6 THEMIS NA NA NA NA NA 0,91546874 0,9925589

5 CD3D TRAT1 ICOS THEMIS CTLA4 NA NA NA NA NA 0,90350479 0,9925493

5 T AT1 SIRPG CD6 THEMIS CTLA4 NA NA NA NA NA 0,92144708 0,9925352

7 TRAT1 SIRPG CD3G ICOS CD6 THEMIS CTLA4 NA NA NA 0,92536983 0,9925195

7 CD3D TRAT1 SIRPG CD3G ICOS CTLA4 CD28 NA NA NA 0,9147101 0,9924940

4 TRAT1 CD3G ICOS CTLA4 NA NA NA NA NA NA 0,89064664 0,9924883

4 TRAT1 ICOS CD6 CTLA4 NA NA NA NA NA NA 0,90050848 0,9924563

7 TRAT1 SIRPG ICOS CD6 THEMIS CTLA4 CD5 NA NA NA 0,92971427 0,9924560

6 TRAT1 CD3G ICOS CD6 THEMIS CTLA4 NA NA NA NA 0,91863151 0,9924508

5 TRAT1 CD3G CD6 CTLA4 CD28 NA NA NA NA NA 0,91123736 0,9924504

6 CD3D SIRPG ICOS CD6 CTLA4 CD28 NA NA NA NA 0,91888252 0,99241

3 SIRPG CTLA4 CD28 NA NA NA NA NA NA NA 0,86316774 0,9924149

5 CD3D TRAT1 ICOS CD6 CTLA4 NA NA NA NA NA 0,91417373 0,9924107

4 CD3D SIRPG ICOS CD28 NA NA NA NA NA NA 0,90056906 0,9924011

5 TRAT1 THEMIS CTLA4 CD5 CD28 NA NA NA NA NA 0,89495368 0,992398

6 CD3D TRAT1 CD3G THEMIS CTLA4 CD28 NA NA NA NA 0,90753957 0,9923966

5 SIRPG CD3G ICOS THEMIS CD28 NA NA NA NA NA 0,90346977 0,9923952

6 TRAT1 SIRPG ICOS CD6 THEMIS CTLA4 NA NA NA NA 0,91988657 0,9923925

3 TRAT1 THEMIS CD28 NA NA NA NA NA NA NA 0,82875213 0,9923728

7 SIRPG CD3G ICOS CD6 THEMIS CTLA4 CD28 NA NA NA 0,92501515 0,992371

8 TRAT1 SIRPG CD3G ICOS CD6 THEMIS CD5 CD28 NA NA 0,92990725 0,9923556

5 CD3D TRAT1 SIRPG CD6 CD28 NA NA NA NA NA 0,91981414 0,992342

4 CD3D ICOS CTLA4 CD28 NA NA NA NA NA NA 0,88537661 0,9923212

6 CD3D TRAT1 CD3G ICOS THEMIS CTLA4 NA NA NA NA 0,91108042 0,9922926

4 TRAT1 THEMIS CTLA4 CD28 NA NA NA NA NA NA 0,85892543 0,9922915

4 TRAT1 CD3G THEMIS CTLA4 NA NA NA NA NA NA 0,89214346 0,992285

5 CD3D TRAT1 CD3G ICOS THEMIS NA NA NA NA NA 0,90569101 0,9922771

5 TRAT1 ICOS THEMIS CTLA4 CD5 NA NA NA NA NA 0,90486346 0,9922676

5 CD3D TRAT1 CD3G THEMIS CD28 NA NA NA NA NA 0,89813319 0,9922621

6 CD3D TRAT1 CD3G ICOS CD6 CD28 NA NA NA NA 0,91683737 0,992242

5 T AT1 SIRPG ICOS CD6 THEMIS NA NA NA NA NA 0,91916855 0,9922358

3 TRAT1 CD3G CD28 NA NA NA NA NA NA NA 0,86397842 0,99222

6 TRAT1 SIRPG CD3G ICOS CD6 THEMIS NA NA NA NA 0,92206727 0,992219

7 CD3D TRAT1 SIRPG CD3G THEMIS CTLA4 CD28 NA NA NA 0,91707146 0,9922074

5 CD3D TRAT1 ICOS CD6 THEMIS NA NA NA NA NA 0,9174144 0,9921944

4 CD3D TRAT1 THEMIS CTLA4 NA NA NA NA NA NA 0,90302692 0,9921758

6 TRAT1 ICOS CD6 THEMIS CTLA4 CD28 NA NA NA NA 0,90316661 0,9921754

6 TRAT1 ICOS CD6 THEMIS CTLA4 CD5 NA NA NA NA 0,92358417 0,9921273

4 SIRPG CD6 CTLA4 CD28 NA NA NA NA NA NA 0,90804876 0,9921104

6 CD3D SIRPG ICOS THEMIS CTLA4 CD28 NA NA NA NA 0,91143269 0,9920783

5 CD3D ICOS CD6 CTLA4 CD28 NA NA NA NA NA 0,90838448 0,9920565

6 SIRPG CD3G ICOS CD6 CTLA4 CD28 NA NA NA NA 0,91883722 0,9920390

2 TRAT1 CD6 NA NA NA NA NA NA NA NA 0,89722732 0,9919749

4 CD3D TRAT1 CD6 THEMIS NA NA NA NA NA NA 0,91173603 0,9919719

5 TRAT1 SIRPG CD3G CTLA4 CD28 NA NA NA NA NA 0,90292093 0,9919662

6 CD3D TRAT1 ICOS CD6 THEMIS CTLA4 NA NA NA NA 0,92006394 0,9919638

7 CD3D TRAT1 SIRPG CD3G ICOS THEMIS CTLA4 NA NA NA 0,91760667 0,9919351

5 TRAT1 ICOS CD6 THEMIS CD28 NA NA NA NA NA 0,90059338 0,991931

4 TRAT1 CD3G CD6 CD28 NA NA NA NA NA NA 0,90187072 0,9919290

7 CD3D TRAT1 CD3G CD6 THEMIS CTLA4 CD28 NA NA NA 0,92133183 0,9919283

8 CD3D TRAT1 SIRPG CD3G ICOS CD6 CTLA4 CD28 NA NA 0,92537556 0,9919223

5 TRAT1 SIRPG CD3G THEMIS CTLA4 NA NA NA NA NA 0,90792052 0,9919111

4 CD3G ICOS CD6 CD28 NA NA NA NA NA NA 0,90444084 0,9919091

6 CD3D TRAT1 SIRPG ICOS CD6 CTLA4 NA NA NA NA 0,92028228 0,9918948

7 CD3D TRAT1 ICOS CD6 CTLA4 CD5 CD28 NA NA NA 0,923021 0,9918545

3 TRAT1 SIRPG CTLA4 NA NA NA NA NA NA NA 0,88519704 0,9918440

5 CD3G ICOS THEMIS CTLA4 CD28 NA NA NA NA NA 0,88933409 0,9918435

3 TRAT1 CD3G ICOS NA NA NA NA NA NA NA 0,88899338 0,9918305

6 SIRPG CD3G ICOS CD6 THEMIS CD28 NA NA NA NA 0,92374729 0,9918166

7 SI PG ICOS CD6 THEMIS CTLA4 CD5 CD28 NA NA NA 0,92935925 0,9918050

3 CD3D ICOS CD28 NA NA NA NA NA NA NA 0,88165987 0,991797

6 CD3D TRAT1 ICOS CTLA4 CD5 CD28 NA NA NA NA 0,91136405 0,9917765

7 CD3D SIRPG ICOS CD6 THEMIS CTLA4 CD28 NA NA NA 0,92599806 0,9917711

6 SIRPG ICOS THEMIS CTLA4 CD5 CD28 NA NA NA NA 0,91305625 0,991768

5 TRAT1 ICOS THEMIS CTLA4 CD28 NA NA NA NA NA 0,87079149 0,991765

6 CD3D TRAT1 CD3G CD6 THEMIS CD28 NA NA NA NA 0,91383453 0,9917008

4 CD3D ICOS CD6 CD28 NA NA NA NA NA NA 0,90604889 0,9916955

8 CD3D TRAT1 SIRPG CD3G CD6 THEMIS CTLA4 CD28 NA NA 0,92789505 0,9916878

7 CD3D SIRPG CD3G ICOS THEMIS CTLA4 CD28 NA NA NA 0,91755058 0,9916743

6 CD3D TRAT1 SIRPG CD6 THEMIS CTLA4 NA NA NA NA 0,92755961 0,9916737

5 CD3D TRAT1 ICOS THEMIS CD5 NA NA NA NA NA 0,91502494 0,9916730

5 CD3D SIRPG ICOS CD6 CD28 NA NA NA NA NA 0,91680779 0,9916710

6 CD3D TRAT1 SIRPG CD3G THEMIS CD28 NA NA NA NA 0,9100072 0,99166

6 CD3G ICOS CD6 THEMIS CTLA4 CD28 NA NA NA NA 0,91457397 0,9916450

6 CD3D TRAT1 ICOS CD6 CD5 CD28 NA NA NA NA 0,92064035 0,9916348

5 CD3D TRAT1 SIRPG CD6 THEMIS NA NA NA NA NA 0,91985596 0,9916039

4 ICOS CD6 CTLA4 CD28 NA NA NA NA NA NA 0,88286614 0,9915851

3 SIRPG ICOS CTLA4 NA NA NA NA NA NA NA 0,86137403 0,9915732

5 SIRPG CD3G THEMIS CTLA4 CD28 NA NA NA NA NA 0,9039855 0,9915635

7 CD3D TRAT1 SIRPG ICOS CTLA4 CD5 CD28 NA NA NA 0,91924397 0,9915373

6 CD3D TRAT1 SIRPG CD3G ICOS CD28 NA NA NA NA 0,91176413 0,9915344

6 SIRPG ICOS CD6 THEMIS CD5 CD28 NA NA NA NA 0,92930739 0,991512

6 TRAT1 SIRPG CD3G CD6 CTLA4 CD28 NA NA NA NA 0,92311371 0,9915076

5 CD3D SIRPG ICOS THEMIS CD28 NA NA NA NA NA 0,90975765 0,9914837

7 CD3D TRAT1 SIRPG ICOS THEMIS CTLA4 CD5 NA NA NA 0,92361035 0,9914807

8 CD3D TRAT1 SIRPG ICOS CD6 CTLA4 CD5 CD28 NA NA 0,92837524 0,9914675

2 TRAT1 THEMIS NA NA NA NA NA NA NA NA 0,83179274 0,9914571

6 CD3D TRAT1 ICOS THEMIS CTLA4 CD5 NA NA NA NA 0,91810727 0,991453

7 CD3D TRAT1 CD3G ICOS CD6 THEMIS CTLA4 NA NA NA 0,92289091 0,9914322

5 CD3D TRAT1 ICOS CD5 CD28 NA NA NA NA NA 0,90989077 0,9913892

6 CD3D TRAT1 SIRPG CD3G ICOS THEMIS NA NA NA NA 0,91267859 0,9913583

5 CD3D TRAT1 CD6 THEMIS CTLA4 NA NA NA NA NA 0,92085639 0,9913414

5 T AT1 CD3G ICOS CD6 CTLA4 NA NA NA NA NA 0,91455279 0,9913387

4 TRAT1 SIRPG CD3G THEMIS NA NA NA NA NA NA 0,89396218 0,9913310

6 CD3D CD3G ICOS THEMIS CTLA4 CD28 NA NA NA NA 0,90838222 0,9913296

5 SIRPG ICOS THEMIS CD5 CD28 NA NA NA NA NA 0,91294403 0,9913241

3 TRAT1 CD6 THEMIS NA NA NA NA NA NA NA 0,8944801 0,9912899

7 CD3D TRAT1 SIRPG THEMIS CTLA4 CD5 CD28 NA NA NA 0,92430594 0,9912897

4 SIRPG CD3G ICOS CD28 NA NA NA NA NA NA 0,89528132 0,9912736

6 CD3D TRAT1 ICOS CD6 THEMIS CD5 NA NA NA NA 0,92387432 0,9912630

5 TRAT1 CD3G CD6 THEMIS CTLA4 NA NA NA NA NA 0,91665251 0,9912381

8 CD3D TRAT1 CD3G ICOS THEMIS CTLA4 CD5 CD28 NA NA 0,92094519 0,9912351

6 CD3D SIRPG ICOS CD6 THEMIS CD28 NA NA NA NA 0,92495674 0,9912333

3 TRAT1 THEMIS CD5 NA NA NA NA NA NA NA 0,88710646 0,9912272

4 TRAT1 CD3G CD6 THEMIS NA NA NA NA NA NA 0,90305076 0,9912264

8 CD3D TRAT1 SIRPG CD6 THEMIS CTLA4 CD5 CD28 NA NA 0,93330268 0,9912244

6 CD3D TRAT1 SIRPG ICOS THEMIS CD5 NA NA NA NA 0,92016086 0,9912206

5 TRAT1 SIRPG CD3G ICOS CTLA4 NA NA NA NA NA 0,903864 0,9912167

NA NA NA NA NA NA 0,91096521 0,9911981

4 TRAT1 CD6 THEMIS CD 5

7 CD3D TRAT1 ICOS CD6 THEMIS CTLA4 CD5 NA NA NA 0,92780877 0,9911747

5 CD3D TRAT1 SIRPG ICOS CD6 NA NA NA NA NA 0,91629523 0,9911745

6 SIRPG ICOS CD6 THEMIS CTLA4 CD28 NA NA NA NA 0,91746671 0,9911713

7 CD3D TRAT1 CD6 THEMIS CTLA4 CD5 CD28 NA NA NA 0,92738812 0,9911641

4 TRAT1 ICOS THEMIS CD28 NA NA NA NA NA NA 0,85901269 0,9911592

8 CD3D SIRPG CD3G ICOS CD6 THEMIS CTLA4 CD28 NA NA 0,92812469 0,9911569

5 SI PG CD6 THEMIS CTLA4 CD28 NA NA NA NA NA 0,91789507 0,9911434

4 CD3G ICOS THEMIS CD28 NA NA NA NA NA NA 0,8822139 0,9911358

9 CD3D TRAT1 CD3G ICOS CD6 THEMIS CTLA4 CD5 CD28 NA 0,92927319 0,991122

8 CD3D TRAT1 SIRPG CD3G ICOS CD6 THEMIS CTLA4 NA NA 0,92718175 0,9911212

6 CD3D TRAT1 CD3G ICOS CD6 THEMIS NA NA NA NA 0,91803017 0,9911194

7 CD3D TRAT1 SIRPG CD3G CD6 THEMIS CD28 NA NA NA 0,92184257 0,9911088

6 SIRPG ICOS CD6 CTLA4 CD5 CD28 NA NA NA NA 0,91875344 0,9911061

5 CD3D SIRPG THEMIS CTLA4 CD28 NA NA NA NA NA 0,91242363 0,9910948

8 CD3D TRAT1 SIRPG ICOS CD6 THEMIS CTLA4 CD5 NA NA 0,93145379 0,9910891

6 CD3D TRAT1 CD6 THEMIS CD5 CD28 NA NA NA NA 0,92098087 0,9910887

5 SIRPG CD3G ICOS THEMIS CTLA4 NA NA NA NA NA 0,90786384 0,9910787

5 CD3G ICOS CD6 THEMIS CD28 NA NA NA NA NA 0,91232682 0,9910776

9 CD3D TRAT1 SIRPG CD3G ICOS THEMIS CTLA4 CD5 CD28 NA 0,92622882 0,9910458

6 SIRPG CD3G CD6 THEMIS CTLA4 CD28 NA NA NA NA 0,9246289 0,9910418

6 CD3D TRAT1 THEMIS CTLA4 CD5 CD28 NA NA NA NA 0,91572715 0,9910166

4 SIRPG THEMIS CTLA4 CD28 NA NA NA NA NA NA 0,88424663 0,9910109

7 CD3D TRAT1 SIRPG CD3G ICOS CD6 CD28 NA NA NA 0,92250571 0,9909984

2 TRAT1 CTLA4 NA NA NA NA NA NA NA NA 0,84682548 0,9909741

5 SIRPG ICOS THEMIS CTLA4 CD28 NA NA NA NA NA 0,8893757 0,9909641

5 TRAT1 SIRPG THEMIS CTLA4 CD5 NA NA NA NA NA 0,9170253 0,9909573

7 CD3D CD3G ICOS CD6 THEMIS CTLA4 CD28 NA NA NA 0,92189584 0,9909569

7 T AT1 CD3G ICOS CD6 CTLA4 CD5 CD28 NA NA NA 0,9236027 0,9909312

3 SIRPG CD6 CD28 NA NA NA NA NA NA NA 0,89902066 0,9909091

6 TRAT1 SIRPG CD3G CD6 THEMIS CTLA4 NA NA NA NA 0,92543329 0,9909012

5 ICOS CD6 CTLA4 CD5 CD28 NA NA NA NA NA 0,90441163 0,990

10 CD3D TRAT1 SIRPG CD3G ICOS CD6 THEMIS CTLA4 CD5 CD28 0,93310568 0,9908758

5 TRAT1 CD6 CTLA4 CD5 CD28 NA NA NA NA NA 0,91404169 0,990874

5 SIRPG ICOS CTLA4 CD5 CD28 NA NA NA NA NA 0,89950887 0,9908685

7 CD3D TRAT1 SIRPG CD6 THEMIS CD5 CD28 NA NA NA 0,92804883 0,9908556

6 TRAT1 CD3G ICOS THEMIS CTLA4 CD5 NA NA NA NA 0,91612596 0,9908534

6 CD3D TRAT1 SIRPG THEMIS CD5 CD28 NA NA NA NA 0,91895894 0,9908441

5 CD3D TRAT1 THEMIS CD5 CD28 NA NA NA NA NA 0,90866312 0,990830

7 CD3D TRAT1 SIRPG ICOS CD6 CD5 CD28 NA NA NA 0,92582712 0,990808

6 CD3D SIRPG CD3G ICOS THEMIS CD28 NA NA NA NA 0,91410687 0,9908065

6 CD3D SIRPG CD6 THEMIS CTLA4 CD28 NA NA NA NA 0,9277799 0,9908015

4 TRAT1 CD6 THEMIS CTLA4 NA NA NA NA NA NA 0,90752118 0,9907956

5 CD3D SIRPG ICOS THEMIS CTLA4 NA NA NA NA NA 0,91181059 0,9907821

4 TRAT1 SIRPG THEMIS CD5 NA NA NA NA NA NA 0,90614669 0,9907795

4 TRAT1 SIRPG CD6 CTLA4 NA NA NA NA NA NA 0,91774217 0,9907701

6 TRAT1 CD3G ICOS CTLA4 CD5 CD28 NA NA NA NA 0,90915943 0,9907681

5 TRAT1 ICOS CD6 CTLA4 CD5 NA NA NA NA NA 0,91481599 0,9907646

7 CD3D TRAT1 SIRPG ICOS CD6 THEMIS CD5 NA NA NA 0,92734818 0,9907611

7 CD3D TRAT1 CD3G ICOS THEMIS CD5 CD28 NA NA NA 0,91764989 0,9907611

3 T AT1 THEMIS CTLA4 NA NA NA NA NA NA NA 0,86572037 0,9907558

7 CD3D SIRPG ICOS THEMIS CTLA4 CD5 CD28 NA NA NA 0,92380825 0,9907422

7 TRAT1 CD3G CD6 THEMIS CTLA4 CD5 CD28 NA NA NA 0,92494371 0,9907387

6 ICOS CD6 THEMIS CTLA4 CD5 CD28 NA NA NA NA 0,91905416 0,9907265

3 TRAT1 CD6 CTLA4 NA NA NA NA NA NA NA 0,90266892 0,9907182

6 CD3D TRAT1 SIRPG ICOS CD5 CD28 NA NA NA NA 0,91753956 0,9907177

6 TRAT1 SIRPG CD6 THEMIS CTLA4 CD5 NA NA NA NA 0,93130324 0,9907155

8 CD3D TRAT1 CD3G ICOS CD6 THEMIS CD5 CD28 NA NA 0,92589481 0,9907042

8 CD3D SIRPG ICOS CD6 THEMIS CTLA4 CD5 CD28 NA NA 0,93257549 0,990701

6 TRAT1 SIRPG CD6 CTLA4 CD5 CD28 NA NA NA NA 0,92628419 0,9906398

4 CD3G THEMIS CTLA4 CD28 NA NA NA NA NA NA 0,87991921 0,9906230

5 SIRPG CD3G ICOS CD6 CD28 NA NA NA NA NA 0,91749706 0,9906137

5 TRAT1 CD6 THEMIS CTLA4 CD5 NA NA NA NA NA 0,92349844 0,9906116

6 TRAT1 CD3G THEMIS CTLA4 CD5 CD28 NA NA NA NA 0,90984606 0,9906088

4 TRAT1 ICOS CD6 CD5 NA NA NA NA NA NA 0,91235322 0,9905954

7 TRAT1 CD3G ICOS CD6 THEMIS CTLA4 CD5 NA NA NA 0,92819432 0,990584

5 CD3D CD3G ICOS THEMIS CD28 NA NA NA NA NA 0,90383761 0,9905734

3 ICOS CTLA4 CD28 NA NA NA NA NA NA NA 0,82394716 0,9905575

4 TRAT1 ICOS CTLA4 CD5 NA NA NA NA NA NA 0,89347178 0,9905397

7 T AT1 SIRPG CD3G THEMIS CTLA4 CD5 CD28 NA NA NA 0,9209175 0,9905234

7 TRAT1 SIRPG CD3G ICOS THEMIS CTLA4 CD5 NA NA NA 0,92273491 0,9905228

3 ICOS CD6 CD28 NA NA NA NA NA NA NA 0,88279762 0,9905206

5 CD3G CD6 THEMIS CTLA4 CD28 NA NA NA NA NA 0,91053697 0,9905134

7 SIRPG CD3G ICOS THEMIS CTLA4 CD5 CD28 NA NA NA 0,92227294 0,990506

8 TRAT1 SIRPG CD3G CD6 THEMIS CTLA4 CD5 CD28 NA NA 0,93223637 0,9905058

4 TRAT1 THEMIS CTLA4 CD5 NA NA NA NA NA NA 0,90294688 0,9904856

5 TRAT1 SIRPG CD6 THEMIS CD5 NA NA NA NA NA 0,9213695 0,9904763

4 TRAT1 CD6 CD5 CD28 NA NA NA NA NA NA 0,90393207 0,9904351

5 TRAT1 CD3G ICOS THEMIS CD5 NA NA NA NA NA 0,91223395 0,9904345

8 SIRPG CD3G ICOS CD6 THEMIS CTLA4 CD5 CD28 NA NA 0,93307922 0,9904274

2 TRAT1 SIRPG NA NA NA NA NA NA NA NA 0,87069197 0,9904078

4 SIRPG CD3G THEMIS CD28 NA NA NA NA NA NA 0,89072646 0,9903998

7 CD3D TRAT1 SIRPG CD3G ICOS CD6 THEMIS NA NA NA 0,92251677 0,9903937

5 ICOS CD6 THEMIS CD5 CD28 NA NA NA NA NA 0,91853218 0,9903617

8 CD3D TRAT1 SIRPG CD3G ICOS THEMIS CD5 CD28 NA NA 0,92325648 0,990355

7 CD3G ICOS CD6 THEMIS CTLA4 CD5 CD28 NA NA NA 0,92636889 0,9903484

5 TRAT1 ICOS CD6 THEMIS CTLA4 NA NA NA NA NA 0,90918448 0,9903426

3 CD6 CTLA4 CD28 NA NA NA NA NA NA NA 0,87354046 0,9903407

8 TRAT1 SIRPG CD3G ICOS CD6 CTLA4 CD5 CD28 NA NA 0,92956496 0,9903114

4 ICOS CD6 CD5 CD28 NA NA NA NA NA NA 0,89999242 0,9903102

6 T AT1 SIRPG CD3G ICOS CD6 CTLA4 NA NA NA NA 0,92129663 0,9903060

5 TRAT1 SIRPG ICOS CTLA4 CD5 NA NA NA NA NA 0,90675134 0,9903032

2 SIRPG CD28 NA NA NA NA NA NA NA NA 0,834124 0,9903020

4 SIRPG CD6 THEMIS CD28 NA NA NA NA NA NA 0,91115019 0,9902975

7 CD3D SIRPG CD3G ICOS CD6 THEMIS CD28 NA NA NA 0,92488559 0,9902972

6 CD3D ICOS CD6 THEMIS CTLA4 CD28 NA NA NA NA 0,91749144 0,990275

4 TRAT1 CD3G ICOS CD6 NA NA NA NA NA NA 0,91342347 0,9902747

4 CD3G ICOS THEMIS CTLA4 NA NA NA NA NA NA 0,89270105 0,9902719

7 TRAT1 SIRPG CD3G ICOS CTLA4 CD5 CD28 NA NA NA 0,91855677 0,9902493

6 TRAT1 CD3G CD6 THEMIS CD5 CD28 NA NA NA NA 0,91622549 0,9902485

9 CD3D TRAT1 SIRPG CD3G ICOS CD6 THEMIS CD5 CD28 NA 0,9299533 0,9902475

6 TRAT1 SIRPG ICOS CD6 CTLA4 CD5 NA NA NA NA 0,921982 0,9902442

6 CD3D CD3G ICOS CD6 THEMIS CD28 NA NA NA NA 0,91811539 0,9902335

6 CD3G ICOS THEMIS CTLA4 CD5 CD28 NA NA NA NA 0,91189759 0,9902197

8 TRAT1 SIRPG CD3G ICOS CD6 THEMIS CTLA4 CD5 NA NA 0,93224702 0,9902078

7 CD3D ICOS CD6 THEMIS CTLA4 CD5 CD28 NA NA NA 0,92683996 0,9902047

4 SIRPG ICOS CD6 CTLA4 NA NA NA NA NA NA 0,90051623 0,9901932

5 SIRPG ICOS CD6 THEMIS CD28 NA NA NA NA NA 0,91916269 0,9901805

3 CD3D ICOS CTLA4 NA NA NA NA NA NA NA 0,88129112 0,9901763

4 TRAT1 SIRPG CD3G CD28 NA NA NA NA NA NA 0,89327858 0,9901716

6 SIRPG CD6 THEMIS CTLA4 CD5 CD28 NA NA NA NA 0,93053559 0,9901690

4 CD3D SIRPG THEMIS CD28 NA NA NA NA NA NA 0,90525912 0,9901676

5 T AT1 SIRPG CTLA4 CD5 CD28 NA NA NA NA NA 0,90862751 0,9901648

6 TRAT1 CD3G ICOS CD6 THEMIS CD5 NA NA NA NA 0,9238703 0,990148

5 SIRPG ICOS THEMIS CTLA4 CD5 NA NA NA NA NA 0,91453957 0,9901257

5 ICOS THEMIS CTLA4 CD5 CD28 NA NA NA NA NA 0,89586446 0,9901103

5 CD3D CD3G ICOS CTLA4 CD28 NA NA NA NA NA 0,90086445 0,9900802

7 CD3D SIRPG ICOS CD6 THEMIS CD5 CD28 NA NA NA 0,93012405 0,9900791

3 TRAT1 ICOS CD5 NA NA NA NA NA NA NA 0,89528191 0,9900756

6 SIRPG CD3G ICOS CD6 THEMIS CTLA4 NA NA NA NA 0,92514153 0,9900705

5 SIRPG ICOS CD6 CD5 CD28 NA NA NA NA NA 0,91590245 0,9900490

6 TRAT1 CD3G ICOS CD6 CD5 CD28 NA NA NA NA 0,92163104 0,9900310

5 TRAT1 SIRPG CD3G CD6 CD28 NA NA NA NA NA 0,91671137 0,9900234

5 TRAT1 SIRPG CD3G CD6 THEMIS NA NA NA NA NA 0,91495622 0,9900190

4 ICOS CTLA4 CD5 CD28 NA NA NA NA NA NA 0,87469038 0,9899942

6 CD3D SIRPG ICOS THEMIS CD5 CD28 NA NA NA NA 0,92223714 0,9899926

6 CD3D SIRPG ICOS CD6 THEMIS CTLA4 NA NA NA NA 0,92521955 0,9899897

4 TRAT1 ICOS THEMIS CTLA4 NA NA NA NA NA NA 0,87568926 0,9899882

5 CD3D ICOS THEMIS CTLA4 CD28 NA NA NA NA NA 0,89807492 0,989984

5 CD3D SIRPG CD6 THEMIS CD28 NA NA NA NA NA 0,92199117 0,9899829

5 SIRPG CD3G CD6 THEMIS CD28 NA NA NA NA NA 0,91585331 0,9899591

4 CD3D SIRPG ICOS CTLA4 NA NA NA NA NA NA 0,89723062 0,9899414

6 SI PG ICOS CD6 THEMIS CTLA4 CD5 NA NA NA NA 0,92878111 0,9899334

6 CD3D ICOS THEMIS CTLA4 CD5 CD28 NA NA NA NA 0,91544616 0,9899319

5 TRAT1 CD3G THEMIS CD5 CD28 NA NA NA NA NA 0,89887526 0,9899310

4 CD3D SIRPG ICOS THEMIS NA NA NA NA NA NA 0,90826756 0,989857

4 TRAT1 CTLA4 CD5 CD28 NA NA NA NA NA NA 0,88721275 0,9898539

5 SIRPG THEMIS CTLA4 CD5 CD28 NA NA NA NA NA 0,91309143 0,9898093

2 CD3D ICOS NA NA NA NA NA NA NA NA 0,87350288 0,9897506

4 SIRPG CD3G ICOS THEMIS NA NA NA NA NA NA 0,90267303 0,9897423

6 CD3D CD3G ICOS CD6 CTLA4 CD28 NA NA NA NA 0,91556181 0,9897308

7 TRAT1 SIRPG CD3G CD6 THEMIS CD5 CD28 NA NA NA 0,92551359 0,9896921

3 SIRPG THEMIS CD28 NA NA NA NA NA NA NA 0,86547947 0,9896729

6 CD3D ICOS CD6 THEMIS CD5 CD28 NA NA NA NA 0,9242016 0,9896721

4 TRAT1 ICOS CD6 THEMIS NA NA NA NA NA NA 0,9089831 0,9896510

6 CD3G ICOS CD6 THEMIS CD5 CD28 NA NA NA NA 0,92330692 0,9896136

6 TRAT1 SIRPG CD3G ICOS THEMIS CD5 NA NA NA NA 0,91863284 0,9896034

4 CD3G CD6 THEMIS CD28 NA NA NA NA NA NA 0,89600804 0,9896004

5 CD3D TRAT1 CD3G THEMIS CTLA4 NA NA NA NA NA 0,9097367 0,9895643

6 TRAT1 SIRPG CD3G THEMIS CD5 CD28 NA NA NA NA 0,91326145 0,9895428

5 TRAT1 CD3G ICOS CD5 CD28 NA NA NA NA NA 0,90776443 0,9895234

4 SIRPG ICOS THEMIS CD28 NA NA NA NA NA NA 0,88532927 0,9895202

6 CD3D SIRPG CD3G ICOS CTLA4 CD28 NA NA NA NA 0,91161269 0,9895103

5 T AT1 SIRPG CD6 CD5 CD28 NA NA NA NA NA 0,91957353 0,9895080

5 CD3G ICOS CD6 THEMIS CTLA4 NA NA NA NA NA 0,91701015 0,9895027

7 SIRPG CD3G ICOS CD6 THEMIS CD5 CD28 NA NA NA 0,93042895 0,989500

3 CD3G THEMIS CD28 NA NA NA NA NA NA NA 0,85375915 0,9894298

6 SIRPG CD3G ICOS THEMIS CD5 CD28 NA NA NA NA 0,9201824 0,9894088

5 CD3D ICOS CD6 THEMIS CD28 NA NA NA NA NA 0,91606632 0,989395

5 SIRPG CD6 THEMIS CD5 CD28 NA NA NA NA NA 0,92267717 0,9893671

3 SIRPG THEMIS CTLA4 NA NA NA NA NA NA NA 0,88950025 0,9893535

7 TRAT1 SIRPG CD3G ICOS CD6 THEMIS CD5 NA NA NA 0,92774527 0,9893417

5 CD3D CD6 THEMIS CTLA4 CD28 NA NA NA NA NA 0,91723803 0,9893246

4 SIRPG ICOS THEMIS CD5 NA NA NA NA NA NA 0,91290738 0,9892917

4 ICOS THEMIS CD5 CD28 NA NA NA NA NA NA 0,89306622 0,9892911

5 CD3D CD3G ICOS THEMIS CTLA4 NA NA NA NA NA 0,90866119 0,9892466

5 CD3G ICOS THEMIS CD5 CD28 NA NA NA NA NA 0,90887697 0,9892461

4 SIRPG ICOS CD5 CD28 NA NA NA NA NA NA 0,89801405 0,9892384

6 CD3D SIRPG CD3G ICOS THEMIS CTLA4 NA NA NA NA 0,91639379 0,989207

4 SIRPG ICOS THEMIS CTLA4 NA NA NA NA NA NA 0,89172333 0,9891850

5 SIRPG ICOS CD6 THEMIS CD5 NA NA NA NA NA 0,92464094 0,9891773

5 CD3D ICOS THEMIS CD5 CD28 NA NA NA NA NA 0,91360102 0,9891548

7 CD3D SIRPG CD3G ICOS CD6 CTLA4 CD28 NA NA NA 0,92274162 0,9891490

3 CD3G ICOS THEMIS NA NA NA NA NA NA NA 0,88608725 0,9891374

3 T AT1 SIRPG CD6 NA NA NA NA NA NA NA 0,90954506 0,9891067

5 SIRPG ICOS CD6 THEMIS CTLA4 NA NA NA NA NA 0,91985892 0,9890937

4 CD3D SIRPG CTLA4 CD28 NA NA NA NA NA NA 0,90505797 0,9890707

6 CD3D SIRPG CD3G THEMIS CTLA4 CD28 NA NA NA NA 0,91744655 0,9890617

5 CD6 THEMIS CTLA4 CD5 CD28 NA NA NA NA NA 0,91662333 0,9890502

4 CD3D SIRPG THEMIS CTLA4 NA NA NA NA NA NA 0,91403877 0,9890284

5 CD3D SIRPG CD6 CTLA4 CD28 NA NA NA NA NA 0,9216379 0,9890266

6 CD3D TRAT1 SIRPG CD3G THEMIS CTLA4 NA NA NA NA 0,91767219 0,9890262

5 CD3D TRAT1 CD3G ICOS CTLA4 NA NA NA NA NA 0,90630128 0,9890244

5 TRAT1 SIRPG ICOS CD6 CD5 NA NA NA NA NA 0,91724583 0,9890161

7 TRAT1 SIRPG CD3G ICOS CD6 CD5 CD28 NA NA NA 0,92727636 0,9890024

2 CD6 CD28 NA NA NA NA NA NA NA NA 0,83986171 0,9889890

5 ICOS CD6 THEMIS CTLA4 CD5 NA NA NA NA NA 0,92100182 0,9889531

4 TRAT1 SIRPG CD3G ICOS NA NA NA NA NA NA 0,90016281 0,9889351

3 CD3G ICOS CTLA4 NA NA NA NA NA NA NA 0,87143696 0,9889134

6 CD3D TRAT1 CD3G CD6 THEMIS CTLA4 NA NA NA NA 0,92213208 0,9888909

5 CD3D SIRPG ICOS CD6 THEMIS NA NA NA NA NA 0,92127744 0,9888841

4 CD3D THEMIS CTLA4 CD28 NA NA NA NA NA NA 0,89546525 0,98884

4 CD3D ICOS CD6 CTLA4 NA NA NA NA NA NA 0,90325726 0,9888202

3 TRAT1 ICOS THEMIS NA NA NA NA NA NA NA 0,86644133 0,98881

6 CD3D TRAT1 CD3G CD6 CTLA4 CD28 NA NA NA NA 0,91992564 0,9887921

7 CD3D SIRPG CD3G CD6 THEMIS CTLA4 CD28 NA NA NA 0,92834634 0,9887915

4 SI PG CD6 THEMIS CTLA4 NA NA NA NA NA NA 0,92223739 0,9887441

4 TRAT1 SIRPG ICOS CD5 NA NA NA NA NA NA 0,90413892 0,988700

5 CD3D TRAT1 CD3G CTLA4 CD28 NA NA NA NA NA 0,90579722 0,9886934

2 SIRPG ICOS NA NA NA NA NA NA NA NA 0,84976106 0,9886928

4 CD3D ICOS THEMIS CD28 NA NA NA NA NA NA 0,89466203 0,9886921

3 CD3D TRAT1 CTLA4 NA NA NA NA NA NA NA 0,89841489 0,9886916

5 CD3D CD3G THEMIS CTLA4 CD28 NA NA NA NA NA 0,90595078 0,9886910

5 CD3D SIRPG ICOS CD6 CTLA4 NA NA NA NA NA 0,9127209 0,9886544

4 CD3D CD6 CTLA4 CD28 NA NA NA NA NA NA 0,90864617 0,9886397

6 CD3D CD3G CD6 THEMIS CTLA4 CD28 NA NA NA NA 0,92056078 0,9886264

6 TRAT1 SIRPG CD3G ICOS CD5 CD28 NA NA NA NA 0,91698154 0,9886197

4 SIRPG THEMIS CD5 CD28 NA NA NA NA NA NA 0,90369456 0,9885788

7 CD3D TRAT1 CD3G ICOS THEMIS CTLA4 CD5 NA NA NA 0,92168329 0,9885778

5 SIRPG CD3G ICOS CD6 THEMIS NA NA NA NA NA 0,92074118 0,9885654

4 CD3D ICOS THEMIS CTLA4 NA NA NA NA NA NA 0,90042847 0,9885359

6 CD3D ICOS CD6 CTLA4 CD5 CD28 NA NA NA NA 0,91758807 0,9885275

6 CD3D SIRPG ICOS THEMIS CTLA4 CD5 NA NA NA NA 0,92276397 0,9885133

8 CD3D TRAT1 CD3G ICOS CD6 THEMIS CTLA4 CD5 NA NA 0,92875018 0,9884961

7 CD3D SIRPG ICOS CD6 CTLA4 CD5 CD28 NA NA NA 0,92483635 0,9884938

8 CD3D CD3G ICOS CD6 THEMIS CTLA4 CD5 CD28 NA NA 0,92876395 0,9884873

4 ICOS THEMIS CTLA4 CD5 NA NA NA NA NA NA 0,90039246 0,9884822

6 CD3D TRAT1 CD6 THEMIS CTLA4 CD5 NA NA NA NA 0,92845911 0,9884707

9 CD3D SIRPG CD3G ICOS CD6 THEMIS CTLA4 CD5 CD28 NA 0,93314986 0,9884672

6 CD3D CD3G ICOS CD6 THEMIS CTLA4 NA NA NA NA 0,92086031 0,9884623

7 CD3D SIRPG CD3G ICOS CD6 THEMIS CTLA4 NA NA NA 0,92595356 0,9884327

7 CD3D TRAT1 SIRPG CD3G CD6 THEMIS CTLA4 NA NA NA 0,92737963 0,9884307

6 CD3D TRAT1 CD3G ICOS CD6 CTLA4 NA NA NA NA 0,91843511 0,9884264

3 T AT1 CD5 CD28 NA NA NA NA NA NA NA 0,87176308 0,9884082

8 CD3D SIRPG CD3G ICOS THEMIS CTLA4 CD5 CD28 NA NA 0,92668027 0,9884062

4 CD3D TRAT1 CD3G THEMIS NA NA NA NA NA NA 0,89729839 0,9884057

5 CD3D ICOS CD6 THEMIS CTLA4 NA NA NA NA NA 0,91848066 0,9884023

4 ICOS CD6 THEMIS CD5 NA NA NA NA NA NA 0,9179505 0,9883952

8 CD3D TRAT1 CD3G CD6 THEMIS CTLA4 CD5 CD28 NA NA 0,92880838 0,9883791

6 CD3D TRAT1 SIRPG THEMIS CTLA4 CD5 NA NA NA NA 0,92554461 0,988368

7 CD3D SIRPG ICOS CD6 THEMIS CTLA4 CD5 NA NA NA 0,92994757 0,9883626

4 TRAT1 SIRPG CD5 CD28 NA NA NA NA NA NA 0,90111325 0,9883625

7 CD3D TRAT1 SIRPG CD6 THEMIS CTLA4 CD5 NA NA NA 0,93277755 0,9883514

3 ICOS CD5 CD28 NA NA NA NA NA NA NA 0,86833607 0,9883471

5 CD3D TRAT1 THEMIS CTLA4 CD5 NA NA NA NA NA 0,91918872 0,9882937

7 CD3D CD3G ICOS THEMIS CTLA4 CD5 CD28 NA NA NA 0,9206846 0,9882852

4 CD3D TRAT1 CD6 CTLA4 NA NA NA NA NA NA 0,91682768 0,9882537

8 CD3D TRAT1 SIRPG CD3G ICOS THEMIS CTLA4 CD5 NA NA 0,92573444 0,9882324

4 CD6 THEMIS CD5 CD28 NA NA NA NA NA NA 0,90286152 0,9882290

4 CD3D CD6 THEMIS CD28 NA NA NA NA NA NA 0,90866802 0,9882185

4 SI PG CD3G THEMIS CTLA4 NA NA NA NA NA NA 0,90586295 0,9882007

9 CD3D TRAT1 SIRPG CD3G CD6 THEMIS CTLA4 CD5 CD28 NA 0,93343737 0,9881887

8 CD3D TRAT1 CD3G ICOS CD6 CTLA4 CD5 CD28 NA NA 0,9262978 0,9881833

5 TRAT1 SIRPG CD3G ICOS CD6 NA NA NA NA NA 0,91784154 0,9881777

4 CD3G ICOS CD6 THEMIS NA NA NA NA NA NA 0,9129697 0,9881622

7 CD3D SIRPG CD6 THEMIS CTLA4 CD5 CD28 NA NA NA 0,9340145 0,9881487

2 CTLA4 CD28 NA NA NA NA NA NA NA NA 0,78751656 0,9881266

9 CD3D TRAT1 SIRPG CD3G ICOS CD6 THEMIS CTLA4 CD5 NA 0,93165128 0,9881231

5 CD3D SIRPG CD6 THEMIS CTLA4 NA NA NA NA NA 0,92719963 0,9881115

7 CD3D TRAT1 SIRPG CD3G CD6 CTLA4 CD28 NA NA NA 0,92658586 0,9881105

6 CD3D SIRPG ICOS CTLA4 CD5 CD28 NA NA NA NA 0,91571016 0,9880999

6 CD3D TRAT1 ICOS CD6 CTLA4 CD5 NA NA NA NA 0,92092872 0,9880848

7 CD3D TRAT1 CD3G THEMIS CTLA4 CD5 CD28 NA NA NA 0,9203438 0,9880847

5 ICOS CD6 THEMIS CTLA4 CD28 NA NA NA NA NA 0,90065964 0,9880840

6 CD3D TRAT1 SIRPG CD3G CTLA4 CD28 NA NA NA NA 0,91582679 0,9880762

6 CD3D ICOS CD6 THEMIS CTLA4 CD5 NA NA NA NA 0,92548767 0,9880524

8 CD3D TRAT1 SIRPG CD3G THEMIS CTLA4 CD5 CD28 NA NA 0,9266633 0,9880161

4 CD3G CD6 CTLA4 CD28 NA NA NA NA NA NA 0,90174871 0,9880145

4 CD3D T AT1 SIRPG CTLA4 NA NA NA NA NA NA 0,91018186 0,9880085

5 CD3D ICOS THEMIS CTLA4 CD5 NA NA NA NA NA 0,91630297 0,987917

6 CD3D TRAT1 SIRPG CD3G ICOS CTLA4 NA NA NA NA 0,91308206 0,9879081

3 CD3G THEMIS CTLA4 NA NA NA NA NA NA NA 0,88404827 0,9878785

4 THEMIS CTLA4 CD5 CD28 NA NA NA NA NA NA 0,88927497 0,9878524

4 CD6 THEMIS CTLA4 CD28 NA NA NA NA NA NA 0,89455311 0,987835

3 ICOS CD6 CTLA4 NA NA NA NA NA NA NA 0,87773465 0,9878233

3 CD3D CTLA4 CD28 NA NA NA NA NA NA NA 0,88319364 0,9878215

7 CD3D TRAT1 CD3G ICOS CTLA4 CD5 CD28 NA NA NA 0,91816854 0,9877935

6 CD3D SIRPG THEMIS CTLA4 CD5 CD28 NA NA NA NA 0,92573015 0,98775

5 CD3D ICOS CTLA4 CD5 CD28 NA NA NA NA NA 0,90525422 0,9877440

5 CD3D TRAT1 ICOS CTLA4 CD5 NA NA NA NA NA 0,9112925 0,9877226

5 CD3D TRAT1 CD6 THEMIS CD5 NA NA NA NA NA 0,91832713 0,9877195

9 CD3D TRAT1 SIRPG CD3G ICOS CD6 CTLA4 CD5 CD28 NA 0,93023059 0,987717

5 CD3D CD3G ICOS CD6 CD28 NA NA NA NA NA 0,9102596 0,9877034

6 CD3D TRAT1 CD6 CTLA4 CD5 CD28 NA NA NA NA 0,92433404 0,9876977

4 CD3D CD3G ICOS THEMIS NA NA NA NA NA NA 0,90153229 0,9876660

4 CD3D CD3G ICOS CD28 NA NA NA NA NA NA 0,89563595 0,9876146

5 CD3D TRAT1 CD3G CD6 THEMIS NA NA NA NA NA 0,91121231 0,9875983

4 CD3G ICOS CD6 CTLA4 NA NA NA NA NA NA 0,90218129 0,9875895

5 CD3D TRAT1 SIRPG CD6 CTLA4 NA NA NA NA NA 0,92347873 0,9875621

2 SI PG THEMIS NA NA NA NA NA NA NA NA 0,86647858 0,9875573

7 CD3D TRAT1 SIRPG ICOS CD6 CTLA4 CD5 NA NA NA 0,92500836 0,987534

3 ICOS THEMIS CD5 NA NA NA NA NA NA NA 0,90106435 0,9875328

6 CD3D CD6 THEMIS CTLA4 CD5 CD28 NA NA NA NA 0,92693894 0,987530

7 CD3D TRAT1 SIRPG CD6 CTLA4 CD5 CD28 NA NA NA 0,93056172 0,9875249

7 CD3D TRAT1 SIRPG CD3G ICOS CD6 CTLA4 NA NA NA 0,92279687 0,9874937

5 SIRPG CD3G CD6 CTLA4 CD28 NA NA NA NA NA 0,9193498 0,9874639

6 CD3G ICOS CD6 THEMIS CTLA4 CD5 NA NA NA NA 0,92598499 0,9874467

6 CD3G ICOS CD6 CTLA4 CD5 CD28 NA NA NA NA 0,91781469 0,9874350

8 CD3D TRAT1 SIRPG CD3G ICOS CTLA4 CD5 CD28 NA NA 0,92360163 0,9874277

2 ICOS CD28 NA NA NA NA NA NA NA NA 0,79257089 0,9873824

3 CD3G CTLA4 CD28 NA NA NA NA NA NA NA 0,86312932 0,9873732

6 SIRPG CD3G ICOS THEMIS CTLA4 CD5 NA NA NA NA 0,92200216 0,9873705

4 CD3D TRAT1 THEMIS CD5 NA NA NA NA NA NA 0,90960367 0,9873650

7 SIRPG CD3G CD6 THEMIS CTLA4 CD5 CD28 NA NA NA 0,93291862 0,9873352

7 CD3D TRAT1 CD3G ICOS CD6 THEMIS CD5 NA NA NA 0,92311003 0,9873316

3 SIRPG ICOS CD6 NA NA NA NA NA NA NA 0,89489411 0,9873288

5 CD3G ICOS THEMIS CTLA4 CD5 NA NA NA NA NA 0,9140799 0,9873280

7 SIRPG CD3G ICOS CD6 THEMIS CTLA4 CD5 NA NA NA 0,93098174 0,9873272

4 SIRPG CD3G ICOS CTLA4 NA NA NA NA NA NA 0,89281629 0,9873248

6 CD3D TRAT1 SIRPG ICOS CTLA4 CD5 NA NA NA NA 0,91726906 0,9873233

3 CD3D SIRPG THEMIS NA NA NA NA NA NA NA 0,90228266 0,9873019

5 SI PG CD3G CD6 THEMIS CTLA4 NA NA NA NA NA 0,92461843 0,9872786

6 CD3D TRAT1 CD3G ICOS THEMIS CD5 NA NA NA NA 0,91662785 0,987264

4 SIRPG CD3G CTLA4 CD28 NA NA NA NA NA NA 0,89598055 0,9872464

5 CD3D SIRPG CD3G ICOS THEMIS NA NA NA NA NA 0,9099605 0,9871929

7 CD3D CD3G ICOS CD6 THEMIS CD5 CD28 NA NA NA 0,92417272 0,9871757

6 CD3G CD6 THEMIS CTLA4 CD5 CD28 NA NA NA NA 0,92388295 0,9871461

5 CD3D TRAT1 SIRPG CD3G THEMIS NA NA NA NA NA 0,90756801 0,9871276

4 SIRPG ICOS CD6 THEMIS NA NA NA NA NA NA 0,92105369 0,987123

7 CD3D TRAT1 CD3G CD6 THEMIS CD5 CD28 NA NA NA 0,92145156 0,9871201

3 CD3D THEMIS CD28 NA NA NA NA NA NA NA 0,88262123 0,9870879

6 CD3D TRAT1 SIRPG CD6 THEMIS CD5 NA NA NA NA 0,92391723 0,9870873

7 SIRPG CD3G ICOS CD6 CTLA4 CD5 CD28 NA NA NA 0,92609126 0,9870721

6 TRAT1 CD3G CD6 THEMIS CTLA4 CD5 NA NA NA NA 0,92686231 0,987059

4 CD3G CD6 THEMIS CTLA4 NA NA NA NA NA NA 0,91309946 0,9870561

8 CD3D SIRPG CD3G ICOS CD6 THEMIS CD5 CD28 NA NA 0,92899186 0,9870408

6 CD3D SIRPG ICOS CD6 THEMIS CD5 NA NA NA NA 0,9235586 0,9869864

5 CD3D ICOS CD6 THEMIS CD5 NA NA NA NA NA 0,91888256 0,9869731

5 CD3D SIRPG ICOS THEMIS CD5 NA NA NA NA NA 0,91806682 0,9869596

4 CD3D ICOS CD6 THEMIS NA NA NA NA NA NA 0,91494978 0,9869550

6 CD3D SIRPG CD3G CD6 THEMIS CD28 NA NA NA NA 0,92042071 0,9869494

5 CD3D SIRPG CD3G THEMIS CD28 NA NA NA NA NA 0,90872378 0,986945

5 SI PG CD6 THEMIS CTLA4 CD5 NA NA NA NA NA 0,92982001 0,9869391

2 ICOS CTLA4 NA NA NA NA NA NA NA NA 0,80811825 0,986917

5 CD3D CD3G CD6 THEMIS CD28 NA NA NA NA NA 0,91028894 0,9869091

5 CD3D TRAT1 SIRPG THEMIS CD5 NA NA NA NA NA 0,91719725 0,986894

6 SIRPG CD3G THEMIS CTLA4 CD5 CD28 NA NA NA NA 0,92189715 0,98688

3 SIRPG CD6 THEMIS NA NA NA NA NA NA NA 0,90990737 0,9868736

3 CD3D ICOS CD6 NA NA NA NA NA NA NA 0,89323929 0,9868735

3 CD3D THEMIS CTLA4 NA NA NA NA NA NA NA 0,89992408 0,9868720

3 CD3D ICOS THEMIS NA NA NA NA NA NA NA 0,89698279 0,9868707

6 CD3D TRAT1 SIRPG CTLA4 CD5 CD28 NA NA NA NA 0,92207289 0,9868121

5 CD3D CD3G ICOS CD6 THEMIS NA NA NA NA NA 0,91366582 0,9867650

8 CD3D TRAT1 SIRPG CD3G CD6 THEMIS CD5 CD28 NA NA 0,92715386 0,9867611

5 CD3D ICOS CD6 CD5 CD28 NA NA NA NA NA 0,91194348 0,9867414

7 CD3D SIRPG CD3G ICOS THEMIS CD5 CD28 NA NA NA 0,92316604 0,9867381

6 CD3D SIRPG CD3G ICOS CD6 CD28 NA NA NA NA 0,91804005 0,9867348

7 TRAT1 SIRPG CD3G CD6 THEMIS CTLA4 CD5 NA NA NA 0,93222052 0,9867194

8 CD3D TRAT1 SIRPG CD3G ICOS CD6 THEMIS CD5 NA NA 0,92623451 0,9866882

4 CD3D CD6 THEMIS CTLA4 NA NA NA NA NA NA 0,91892559 0,9866812

5 TRAT1 CD3G THEMIS CTLA4 CD5 NA NA NA NA NA 0,91431468 0,9866776

6 CD3D CD3G ICOS THEMIS CD5 CD28 NA NA NA NA 0,9167512 0,986676

3 CD3D SIRPG ICOS NA NA NA NA NA NA NA 0,88900399 0,9866761

5 CD3D SIRPG CD3G ICOS CD28 NA NA NA NA NA 0,90735111 0,9866526

5 CD3D THEMIS CTLA4 CD5 CD28 NA NA NA NA NA 0,91549209 0,9866419

3 SI PG ICOS THEMIS NA NA NA NA NA NA NA 0,88930268 0,9866301

7 CD3D TRAT1 SIRPG CD3G ICOS THEMIS CD5 NA NA NA 0,92076687 0,98662

6 CD3D TRAT1 SIRPG CD3G CD6 THEMIS NA NA NA NA 0,91808459 0,9866125

4 CD3D ICOS THEMIS CD5 NA NA NA NA NA NA 0,91223475 0,9866085

6 CD3D SIRPG CD6 THEMIS CD5 CD28 NA NA NA NA 0,92680687 0,9866010

4 CD3D CD3G THEMIS CD28 NA NA NA NA NA NA 0,89360165 0,9866003

5 CD3D TRAT1 CTLA4 CD5 CD28 NA NA NA NA NA 0,91296067 0,9865912

4 ICOS THEMIS CTLA4 CD28 NA NA NA NA NA NA 0,85948033 0,9865482

4 SIRPG THEMIS CTLA4 CD5 NA NA NA NA NA NA 0,91634555 0,9865416

5 CD3G ICOS CTLA4 CD5 CD28 NA NA NA NA NA 0,90189864 0,9865301

5 SIRPG CD3G ICOS CD6 CTLA4 NA NA NA NA NA 0,91318308 0,9865189

6 CD3D TRAT1 CD3G THEMIS CD5 CD28 NA NA NA NA 0,91267839 0,9865156

6 TRAT1 SIRPG CD3G THEMIS CTLA4 CD5 NA NA NA NA 0,92281058 0,9864917

5 CD3D TRAT1 CD3G CD6 CD28 NA NA NA NA NA 0,91164874 0,9864872

2 CD3D TRAT1 NA NA NA NA NA NA NA NA 0,88838699 0,9864818

6 SIRPG CD3G ICOS CTLA4 CD5 CD28 NA NA NA NA 0,91478165 0,9864763

6 CD3D SIRPG ICOS CD6 CD5 CD28 NA NA NA NA 0,91982733 0,9864624

6 CD3D SIRPG CD3G ICOS CD6 THEMIS NA NA NA NA 0,91932901 0,9864498

4 ICOS CD6 CTLA4 CD5 NA NA NA NA NA NA 0,89514407 0,9864121

7 CD3D TRAT1 CD3G ICOS CD6 CD5 CD28 NA NA NA 0,92223545 0,9864066

5 CD3D TRAT1 ICOS CD6 CD5 NA NA NA NA NA 0,91458609 0,9863658

5 SI PG ICOS CD6 CTLA4 CD5 NA NA NA NA NA 0,90926411 0,9863383

7 CD3D TRAT1 SIRPG CD3G THEMIS CD5 CD28 NA NA NA 0,92035037 0,9863220

5 CD3G THEMIS CTLA4 CD5 CD28 NA NA NA NA NA 0,90798983 0,9863146

4 CD3D TRAT1 CD3G ICOS NA NA NA NA NA NA 0,90079989 0,9862278

3 CD3D TRAT1 CD6 NA NA NA NA NA NA NA 0,90566512 0,9861230

4 CD3D SIRPG CD6 THEMIS NA NA NA NA NA NA 0,91557641 0,9861072

5 SIRPG CD6 CTLA4 CD5 CD28 NA NA NA NA NA 0,91967329 0,9860868

4 CD3D SIRPG CD6 CD28 NA NA NA NA NA NA 0,91299319 0,9860494

3 THEMIS CD5 CD28 NA NA NA NA NA NA NA 0,8673642 0,986021

5 CD3D CD6 THEMIS CD5 CD28 NA NA NA NA NA 0,91767172 0,9860021

3 CD3D CD6 CD28 NA NA NA NA NA NA NA 0,89584524 0,9859519

5 CD3D TRAT1 CD3G ICOS CD6 NA NA NA NA NA 0,91235004 0,9859391

4 CD6 THEMIS CTLA4 CD5 NA NA NA NA NA NA 0,9188876 0,9859279

3 THEMIS CTLA4 CD28 NA NA NA NA NA NA NA 0,840143 0,9858379

6 TRAT1 CD3G CD6 CTLA4 CD5 CD28 NA NA NA NA 0,92313077 0,9858098

6 TRAT1 CD3G ICOS CD6 CTLA4 CD5 NA NA NA NA 0,9227211 0,9857719

4 ICOS CD6 THEMIS CD28 NA NA NA NA NA NA 0,90006993 0,9857653

8 CD3D TRAT1 SIRPG CD3G ICOS CD6 CD5 CD28 NA NA 0,92627622 0,9857515

5 CD3D SIRPG THEMIS CD5 CD28 NA NA NA NA NA 0,91932239 0,9857326

4 CD3D TRAT1 CD3G CD28 NA NA NA NA NA NA 0,89633828 0,9856698

5 CD3D TRAT1 CD6 CD5 CD28 NA NA NA NA NA 0,91639903 0,9856543

4 SI PG ICOS CTLA4 CD5 NA NA NA NA NA NA 0,89124905 0,9856077

5 CD3G ICOS CD6 THEMIS CD5 NA NA NA NA NA 0,91841011 0,9856009

6 CD3D TRAT1 CD3G ICOS CD5 CD28 NA NA NA NA 0,91495356 0,9855341

2 SIRPG CTLA4 NA NA NA NA NA NA NA NA 0,85511354 0,9855187

7 TRAT1 SIRPG CD3G CD6 CTLA4 CD5 CD28 NA NA NA 0,93064826 0,9855161

6 CD3D TRAT1 SIRPG CD3G CD6 CD28 NA NA NA NA 0,91970461 0,9854365

4 CD3D SIRPG ICOS CD6 NA NA NA NA NA NA 0,90322972 0,9854313

2 CD3G THEMIS NA NA NA NA NA NA NA NA 0,84731245 0,985414

5 CD3D SIRPG ICOS CD5 CD28 NA NA NA NA NA 0,91256672 0,9853939

3 CD6 THEMIS CD28 NA NA NA NA NA NA NA 0,87626805 0,9853929

4 CD3D TRAT1 ICOS CD5 NA NA NA NA NA NA 0,90760245 0,9853701

4 CD6 CTLA4 CD5 CD28 NA NA NA NA NA NA 0,89942641 0,9853096

6 CD3D TRAT1 SIRPG ICOS CD6 CD5 NA NA NA NA 0,91842802 0,9852517

6 CD3D TRAT1 SIRPG CD6 CD5 CD28 NA NA NA NA 0,9238548 0,985232

5 TRAT1 CD3G CD6 THEMIS CD5 NA NA NA NA NA 0,9133932 0,985173

7 TRAT1 SIRPG CD3G ICOS CD6 CTLA4 CD5 NA NA NA 0,92683241 0,9851627

6 SIRPG CD3G ICOS CD6 THEMIS CD5 NA NA NA NA 0,92374991 0,9851581

6 SIRPG CD3G CD6 THEMIS CD5 CD28 NA NA NA NA 0,92337172 0,9851553

2 CD3D THEMIS NA NA NA NA NA NA NA NA 0,88349129 0,9850863

4 CD3G ICOS THEMIS CD5 NA NA NA NA NA NA 0,90899859 0,9850434

5 CD3G CD6 THEMIS CD5 CD28 NA NA NA NA NA 0,91060095 0,9850429

7 CD3D TRAT1 SIRPG CD3G ICOS CD5 CD28 NA NA NA 0,92035261 0,9850428

3 SI PG CD6 CTLA4 NA NA NA NA NA NA NA 0,90183961 0,9850318

4 CD3D ICOS CD5 CD28 NA NA NA NA NA NA 0,90189877 0,9849950

4 TRAT1 CD3G CD6 CTLA4 NA NA NA NA NA NA 0,91474854 0,9849697

5 TRAT1 CD3G ICOS CTLA4 CD5 NA NA NA NA NA 0,91079442 0,9849408

4 ICOS CD6 THEMIS CTLA4 NA NA NA NA NA NA 0,90612186 0,9849310

7 CD3D CD3G ICOS CD6 THEMIS CTLA4 CD5 NA NA NA 0,92605212 0,9849066

3 CD3D SIRPG CD28 NA NA NA NA NA NA NA 0,89658074 0,9849005

8 CD3D SIRPG CD3G ICOS CD6 THEMIS CTLA4 CD5 NA NA 0,92964124 0,9848184

5 SIRPG CD3G ICOS THEMIS CD5 NA NA NA NA NA 0,9163971 0,9847990

3 ICOS CTLA4 CD5 NA NA NA NA NA NA NA 0,86636783 0,9847821

5 CD3D TRAT1 SIRPG CD3G CD28 NA NA NA NA NA 0,90855681 0,9847591

4 SIRPG CD6 THEMIS CD5 NA NA NA NA NA NA 0,91158175 0,984730

3 CD3D CD6 THEMIS NA NA NA NA NA NA NA 0,90418811 0,9847292

3 SIRPG CD3G THEMIS NA NA NA NA NA NA NA 0,88487557 0,9846169

8 CD3D SIRPG CD3G CD6 THEMIS CTLA4 CD5 CD28 NA NA 0,93315487 0,9846086

5 CD3G ICOS CD6 CD5 CD28 NA NA NA NA NA 0,91205494 0,9845881

7 CD3D SIRPG CD3G ICOS THEMIS CTLA4 CD5 NA NA NA 0,92437928 0,9845665

6 CD3D CD3G ICOS THEMIS CTLA4 CD5 NA NA NA NA 0,91963725 0,984519

6 T AT1 SIRPG CD3G ICOS CTLA4 CD5 NA NA NA NA 0,91750752 0,9845162

6 TRAT1 SIRPG CD3G CTLA4 CD5 CD28 NA NA NA NA 0,91976779 0,9844695

6 CD3D TRAT1 SIRPG CD3G ICOS CD6 NA NA NA NA 0,91661125 0,9844656

3 THEMIS CTLA4 CD5 NA NA NA NA NA NA NA 0,89674037 0,984455

6 TRAT1 SIRPG CD3G CD6 THEMIS CD5 NA NA NA NA 0,92106013 0,9844430

5 CD3D TRAT1 SIRPG ICOS CD5 NA NA NA NA NA 0,91227282 0,9844404

5 CD3D TRAT1 SIRPG CD3G ICOS NA NA NA NA NA 0,90725888 0,9843840

7 CD3D CD3G CD6 THEMIS CTLA4 CD5 CD28 NA NA NA 0,92762552 0,9843682

5 TRAT1 CD3G CTLA4 CD5 CD28 NA NA NA NA NA 0,90794616 0,9843681

3 TRAT1 CD3G CTLA4 NA NA NA NA NA NA NA 0,88806514 0,9843430

4 CD3D THEMIS CD5 CD28 NA NA NA NA NA NA 0,90648417 0,9843357

5 CD3D SIRPG CD3G THEMIS CTLA4 NA NA NA NA NA 0,91615561 0,9843297

3 CD6 THEMIS CTLA4 NA NA NA NA NA NA NA 0,90298159 0,9843042

3 CD3G CD6 THEMIS NA NA NA NA NA NA NA 0,88889045 0,9842817

4 SIRPG CTLA4 CD5 CD28 NA NA NA NA NA NA 0,89979693 0,9842349

4 TRAT1 CD3G THEMIS CD5 NA NA NA NA NA NA 0,89972558 0,9842205

4 CD3D CD3G THEMIS CTLA4 NA NA NA NA NA NA 0,90633476 0,9841972

3 CD6 THEMIS CD5 NA NA NA NA NA NA NA 0,89208219 0,9841797

5 TRAT1 SIRPG CD3G CD6 CTLA4 NA NA NA NA NA 0,9230114 0,9841430

6 CD3D SIRPG CD3G CD6 THEMIS CTLA4 NA NA NA NA 0,92550361 0,9841363

5 T AT1 SIRPG CD6 CTLA4 CD5 NA NA NA NA NA 0,92449387 0,9840968

4 TRAT1 CD6 CTLA4 CD5 NA NA NA NA NA NA 0,9158244 0,9840708

5 CD3D CD3G CD6 THEMIS CTLA4 NA NA NA NA NA 0,91889706 0,9840698

5 SIRPG CD3G THEMIS CD5 CD28 NA NA NA NA NA 0,91202321 0,9840687

6 SIRPG CD3G ICOS CD6 CD5 CD28 NA NA NA NA 0,92104287 0,9840526

7 CD3D CD3G ICOS CD6 CTLA4 CD5 CD28 NA NA NA 0,92178736 0,9840477

7 CD3D TRAT1 CD3G CD6 THEMIS CTLA4 CD5 NA NA NA 0,92793083 0,9840165

6 CD3D SIRPG CD6 THEMIS CTLA4 CD5 NA NA NA NA 0,93069329 0,9840110

4 SIRPG CD3G CD6 THEMIS NA NA NA NA NA NA 0,90783124 0,9839422

4 CD3D TRAT1 SIRPG CD6 NA NA NA NA NA NA 0,91311542 0,9839405

8 CD3D SIRPG CD3G ICOS CD6 CTLA4 CD5 CD28 NA NA 0,92699202 0,983936

7 CD3D SIRPG CD3G THEMIS CTLA4 CD5 CD28 NA NA NA 0,92709307 0,9839184

8 CD3D TRAT1 SIRPG CD3G CD6 THEMIS CTLA4 CD5 NA NA 0,93155565 0,9838730

5 CD3D TRAT1 SIRPG CD5 CD28 NA NA NA NA NA 0,91637808 0,9836947

5 TRAT1 SIRPG CD3G THEMIS CD5 NA NA NA NA NA 0,91127465 0,9836930

4 TRAT1 SIRPG CD3G CTLA4 NA NA NA NA NA NA 0,90494087 0,9836368

2 ICOS CD6 NA NA NA NA NA NA NA NA 0,87694884 0,9836192

3 SIRPG THEMIS CD5 NA NA NA NA NA NA NA 0,89940757 0,9835230

3 CD3D TRAT1 SIRPG NA NA NA NA NA NA NA 0,90044565 0,9834822

3 CD3G CD6 CD28 NA NA NA NA NA NA NA 0,88049062 0,9834221

4 CD3D TRAT1 CD5 CD28 NA NA NA NA NA NA 0,90597597 0,9834140

5 CD3D CD3G ICOS CD6 CTLA4 NA NA NA NA NA 0,90975301 0,9834093

4 CD3D CD3G ICOS CTLA4 NA NA NA NA NA NA 0,89646985 0,9834034

5 CD3D CD6 THEMIS CTLA4 CD5 NA NA NA NA NA 0,92502853 0,9833963

6 CD3D CD3G THEMIS CTLA4 CD5 CD28 NA NA NA NA 0,91967972 0,9833645

7 CD3D T AT1 SIRPG CD3G THEMIS CTLA4 CD5 NA NA NA 0,92609573 0,9833259

4 CD3G THEMIS CD5 CD28 NA NA NA NA NA NA 0,89235938 0,983307

5 CD3D SIRPG THEMIS CTLA4 CD5 NA NA NA NA NA 0,92493736 0,9833009

6 CD3D TRAT1 CD3G THEMIS CTLA4 CD5 NA NA NA NA 0,92122502 0,9832985

3 ICOS CD6 CD5 NA NA NA NA NA NA NA 0,87298791 0,9830943

5 CD3D CD3G CD6 CTLA4 CD28 NA NA NA NA NA 0,91428973 0,9830905

2 CD3G ICOS NA NA NA NA NA NA NA NA 0,86306233 0,9830866

6 CD3D SIRPG CD3G CD6 CTLA4 CD28 NA NA NA NA 0,92330184 0,9830622

7 CD3D SIRPG CD3G ICOS CTLA4 CD5 CD28 NA NA NA 0,92071856 0,9830399

6 CD3D CD3G ICOS CTLA4 CD5 CD28 NA NA NA NA 0,91378023 0,9828538

3 ICOS THEMIS CTLA4 NA NA NA NA NA NA NA 0,86259817 0,9828493

5 CD3D ICOS CD6 CTLA4 CD5 NA NA NA NA NA 0,90961735 0,9828102

6 CD3D SIRPG ICOS CD6 CTLA4 CD5 NA NA NA NA 0,91655908 0,9828016

6 CD3D SIRPG CD3G ICOS CD6 CTLA4 NA NA NA NA 0,91628149 0,9827558

2 CD3D CD28 NA NA NA NA NA NA NA NA 0,86681292 0,9827145

2 CD6 CTLA4 NA NA NA NA NA NA NA NA 0,8674238 0,9826711

5 CD3D SIRPG CD3G ICOS CTLA4 NA NA NA NA NA 0,90612894 0,9826014

3 ICOS THEMIS CD28 NA NA NA NA NA NA NA 0,84398968 0,9825983

4 SI PG CD3G CD6 CD28 NA NA NA NA NA NA 0,90718887 0,9825645

3 CD3G ICOS CD6 NA NA NA NA NA NA NA 0,89244442 0,9825477

5 SIRPG CD3G ICOS CD5 CD28 NA NA NA NA NA 0,91174843 0,9824734

7 CD3D TRAT1 CD3G ICOS CD6 CTLA4 CD5 NA NA NA 0,92323837 0,9824099

5 TRAT1 CD3G CD6 CD5 CD28 NA NA NA NA NA 0,91287119 0,9823580

4 CD3G ICOS CD5 CD28 NA NA NA NA NA NA 0,89841247 0,9823575

4 TRAT1 SIRPG CTLA4 CD5 NA NA NA NA NA NA 0,9105026 0,9823268

5 TRAT1 CD3G ICOS CD6 CD5 NA NA NA NA NA 0,91663161 0,9822519

8 CD3D TRAT1 SIRPG CD3G CD6 CTLA4 CD5 CD28 NA NA 0,93100208 0,9822493

6 CD3D SIRPG CD6 CTLA4 CD5 CD28 NA NA NA NA 0,92624712 0,9822205

7 CD3D TRAT1 CD3G CD6 CTLA4 CD5 CD28 NA NA NA 0,9262948 0,9822181

4 SIRPG ICOS CD6 CD5 NA NA NA NA NA NA 0,89229354 0,9821402

8 CD3D TRAT1 SIRPG CD3G ICOS CD6 CTLA4 CD5 NA NA 0,92631722 0,9821285

6 CD3D CD3G ICOS CD6 THEMIS CD5 NA NA NA NA 0,91731564 0,9821057

5 CD3D SIRPG CD3G CTLA4 CD28 NA NA NA NA NA 0,91239996 0,9820628

4 CD3D THEMIS CTLA4 CD5 NA NA NA NA NA NA 0,9172572 0,9820556

6 TRAT1 SIRPG CD3G CD6 CD5 CD28 NA NA NA NA 0,92250385 0,9820307

7 CD3D SIRPG CD3G ICOS CD6 THEMIS CD5 NA NA NA 0,92167734 0,9819424

6 SIRPG CD3G CD6 THEMIS CTLA4 CD5 NA NA NA NA 0,92969334 0,9818740

3 CTLA4 CD5 CD28 NA NA NA NA NA NA NA 0,8633604 0,9817574

4 SI PG CD6 CD5 CD28 NA NA NA NA NA NA 0,90315173 0,9817494

2 THEMIS CTLA4 NA NA NA NA NA NA NA NA 0,84429563 0,9817458

7 CD3D SIRPG CD3G CD6 THEMIS CD5 CD28 NA NA NA 0,92452281 0,9816949

5 CD3D SIRPG ICOS CTLA4 CD5 NA NA NA NA NA 0,90888438 0,9816436

4 CD3D CD3G CTLA4 CD28 NA NA NA NA NA NA 0,8989301 0,9815886

5 CD3G CD6 THEMIS CTLA4 CD5 NA NA NA NA NA 0,92232215 0,9815575

6 TRAT1 SIRPG CD3G ICOS CD6 CD5 NA NA NA NA 0,92002 0,9814134

5 CD3D CD6 CTLA4 CD5 CD28 NA NA NA NA NA 0,91720317 0,9814038

6 CD3D CD3G CD6 THEMIS CD5 CD28 NA NA NA NA 0,91710262 0,9813323

6 CD3D TRAT1 CD3G ICOS CTLA4 CD5 NA NA NA NA 0,91672498 0,9812275

7 CD3D TRAT1 SIRPG CD3G ICOS CTLA4 CD5 NA NA NA 0,92081844 0,9811675

6 CD3D SIRPG CD3G ICOS THEMIS CD5 NA NA NA NA 0,91735722 0,9811302

3 TRAT1 CTLA4 CD5 NA NA NA NA NA NA NA 0,89452415 0,9810975

2 THEMIS CD5 NA NA NA NA NA NA NA NA 0,8680035 0,9810782

5 CD3D CD3G ICOS THEMIS CD5 NA NA NA NA NA 0,91223132 0,981054

4 CD3D ICOS CTLA4 CD5 NA NA NA NA NA NA 0,89952339 0,9810538

6 CD3D TRAT1 CD3G CD6 THEMIS CD5 NA NA NA NA 0,91667556 0,9809910

7 CD3D TRAT1 SIRPG CD3G CTLA4 CD5 CD28 NA NA NA 0,92494529 0,9809381

7 CD3D TRAT1 SIRPG CD3G CD6 THEMIS CD5 NA NA NA 0,92173267 0,9807931

5 SIRPG CD3G THEMIS CTLA4 CD5 NA NA NA NA NA 0,9214964 0,9807467

2 THEMIS CD28 NA NA NA NA NA NA NA NA 0,78573271 0,98073

4 SI PG CD3G ICOS CD6 NA NA NA NA NA NA 0,90306406 0,980597

3 CD6 CD5 CD28 NA NA NA NA NA NA NA 0,86815478 0,9805487

6 CD3D TRAT1 CD3G CTLA4 CD5 CD28 NA NA NA NA 0,91859187 0,9805213

5 CD3D SIRPG CD6 THEMIS CD5 NA NA NA NA NA 0,91653475 0,9804089

4 CD3D SIRPG CD6 CTLA4 NA NA NA NA NA NA 0,91423901 0,9803441

3 ICOS CD6 THEMIS NA NA NA NA NA NA NA 0,91018252 0,9803274

5 CD3D TRAT1 CD3G CD6 CTLA4 NA NA NA NA NA 0,91839195 0,9802831

6 CD3D SIRPG CD3G THEMIS CD5 CD28 NA NA NA NA 0,918856 0,9802811

1 CD28 NA NA NA NA NA NA NA NA NA 0,64119745 0,980275

6 CD3D TRAT1 SIRPG CD6 CTLA4 CD5 NA NA NA NA 0,92662014 0,9802687

3 SIRPG CD3G CD28 NA NA NA NA NA NA NA 0,87975777 0,9801999

5 CD3D SIRPG CTLA4 CD5 CD28 NA NA NA NA NA 0,91850137 0,9801516

7 CD3D SIRPG CD3G ICOS CD6 CD5 CD28 NA NA NA 0,92048091 0,9801287

6 CD3D TRAT1 SIRPG CD3G CD6 CTLA4 NA NA NA NA 0,92354979 0,9800992

6 CD3D CD3G ICOS CD6 CD5 CD28 NA NA NA NA 0,91447101 0,9800868

4 TRAT1 CD3G ICOS CD5 NA NA NA NA NA NA 0,90812811 0,9800252

5 CD3D TRAT1 CD6 CTLA4 CD5 NA NA NA NA NA 0,92197935 0,9799158

4 CD3G THEMIS CTLA4 CD5 NA NA NA NA NA NA 0,910482 0,9798572

4 CD3D CD6 THEMIS CD5 NA NA NA NA NA NA 0,90751647 0,9797766

5 TRAT1 SIRPG CD3G CD5 CD28 NA NA NA NA NA 0,91198843 0,9797742

3 SIRPG CD3G ICOS NA NA NA NA NA NA NA 0,88326079 0,9797234

5 T AT1 SIRPG CD3G ICOS CD5 NA NA NA NA NA 0,91251808 0,9796437

5 CD3D SIRPG CD3G CD6 THEMIS NA NA NA NA NA 0,91166072 0,9795898

6 CD3D TRAT1 SIRPG CD3G THEMIS CD5 NA NA NA NA 0,91644627 0,9795648

3 CD3D CD6 CTLA4 NA NA NA NA NA NA NA 0,90251505 0,9795544

6 SIRPG CD3G CD6 CTLA4 CD5 CD28 NA NA NA NA 0,9256934 0,9795227

6 SIRPG CD3G ICOS CD6 CTLA4 CD5 NA NA NA NA 0,91765713 0,9795222

5 CD3G ICOS CD6 CTLA4 CD5 NA NA NA NA NA 0,91004777 0,9794983

4 CD3D CD3G CD6 THEMIS NA NA NA NA NA NA 0,90164949 0,9794908

5 CD3D TRAT1 CD3G THEMIS CD5 NA NA NA NA NA 0,91010163 0,9794464

2 CD3G CD28 NA NA NA NA NA NA NA NA 0,82366156 0,9793962

5 CD3D CD3G THEMIS CD5 CD28 NA NA NA NA NA 0,90926611 0,9793513

2 CD6 THEMIS NA NA NA NA NA NA NA NA 0,88057346 0,9793125

4 TRAT1 CD3G CD5 CD28 NA NA NA NA NA NA 0,8971309 0,9792570

3 SIRPG ICOS CD5 NA NA NA NA NA NA NA 0,8774974 0,9792333

3 CD3D SIRPG CTLA4 NA NA NA NA NA NA NA 0,90030442 0,979163

3 TRAT1 CD6 CD5 NA NA NA NA NA NA NA 0,89535412 0,9788653

4 CD3D SIRPG CD3G THEMIS NA NA NA NA NA NA 0,90165171 0,9788472

5 CD3D TRAT1 SIRPG CD3G CTLA4 NA NA NA NA NA 0,91437554 0,9788450

5 CD3G CD6 CTLA4 CD5 CD28 NA NA NA NA NA 0,91421028 0,9788121

4 TRAT1 SIRPG CD6 CD5 NA NA NA NA NA NA 0,90785396 0,9787067

4 CD3D TRAT1 CD3G CTLA4 NA NA NA NA NA NA 0,90654437 0,9786680

3 CD3D CD3G THEMIS NA NA NA NA NA NA NA 0,88740937 0,978571

4 CD3D SIRPG THEMIS CD5 NA NA NA NA NA NA 0,91236082 0,9785381

7 CD3D SIRPG CD3G CD6 THEMIS CTLA4 CD5 NA NA NA 0,92853919 0,9784396

1 CTLA4 NA NA NA NA NA NA NA NA NA 0,75681903 0,9783064

5 CD3D TRAT1 SIRPG CTLA4 CD5 NA NA NA NA NA 0,92050868 0,9781870

6 CD3D SIRPG CD3G ICOS CD5 CD28 NA NA NA NA 0,91548771 0,978181

4 CD3D CTLA4 CD5 CD28 NA NA NA NA NA NA 0,90577063 0,9781486

7 CD3D TRAT1 SIRPG CD3G CD6 CD5 CD28 NA NA NA 0,92304723 0,9780040

3 T AT1 CD3G CD6 NA NA NA NA NA NA NA 0,89950978 0,9779817

2 ICOS CD5 NA NA NA NA NA NA NA NA 0,85122584 0,9779487

6 CD3D TRAT1 CD3G ICOS CD6 CD5 NA NA NA NA 0,91515526 0,9778274

6 CD3D CD3G CD6 THEMIS CTLA4 CD5 NA NA NA NA 0,92370532 0,977820

7 CD3D TRAT1 SIRPG CD3G ICOS CD6 CD5 NA NA NA 0,91858137 0,9776906

6 CD3D TRAT1 CD3G CD6 CD5 CD28 NA NA NA NA 0,9170705 0,9776873

5 SIRPG CD3G ICOS CTLA4 CD5 NA NA NA NA NA 0,90813742 0,9775670

5 CD3D CD3G ICOS CD5 CD28 NA NA NA NA NA 0,90809651 0,9774940

5 CD3D SIRPG ICOS CD6 CD5 NA NA NA NA NA 0,90303719 0,9772086

4 TRAT1 SIRPG CD3G CD6 NA NA NA NA NA NA 0,90977627 0,9770909

4 CD3D ICOS CD6 CD5 NA NA NA NA NA NA 0,89374118 0,9770663

2 CD3D CTLA4 NA NA NA NA NA NA NA NA 0,88090848 0,9770572

3 SIRPG CD5 CD28 NA NA NA NA NA NA NA 0,88339036 0,9769112

4 CD3D TRAT1 CTLA4 CD5 NA NA NA NA NA NA 0,91425693 0,9769007

6 CD3D SIRPG CD3G THEMIS CTLA4 CD5 NA NA NA NA 0,9241663 0,9768972

5 SI PG CD3G CTLA4 CD5 CD28 NA NA NA NA NA 0,91506719 0,9768713

4 CD3G ICOS CTLA4 CD5 NA NA NA NA NA NA 0,89700036 0,9768008

5 CD3D SIRPG CD3G CD6 CD28 NA NA NA NA NA 0,91206798 0,9766832

3 CD3D THEMIS CD5 NA NA NA NA NA NA NA 0,90195313 0,9766687

5 SIRPG CD3G CD6 THEMIS CD5 NA NA NA NA NA 0,910972 0,9765796

1 ICOS NA NA NA NA NA NA NA NA NA 0,77842579 0,9765678

5 CD3D SIRPG CD6 CD5 CD28 NA NA NA NA NA 0,91397249 0,9764985

6 TRAT1 SIRPG CD3G CD6 CTLA4 CD5 NA NA NA NA 0,92709427 0,9762077

4 CD3D CD3G ICOS CD6 NA NA NA NA NA NA 0,89684342 0,9761772

4 CD3D CD3G CD6 CD28 NA NA NA NA NA NA 0,8995606 0,9759887

4 CD3G CD6 THEMIS CD5 NA NA NA NA NA NA 0,89741299 0,9759167

7 CD3D SIRPG CD3G ICOS CD6 CTLA4 CD5 NA NA NA 0,91903077 0,9758395

5 CD3D SIRPG CD3G ICOS CD6 NA NA NA NA NA 0,90490536 0,9758066

5 CD3D CD3G THEMIS CTLA4 CD5 NA NA NA NA NA 0,91813897 0,975713

7 CD3D SIRPG CD3G CD6 CTLA4 CD5 CD28 NA NA NA 0,92670887 0,9756824

6 CD3D TRAT1 SIRPG CD3G ICOS CD5 NA NA NA NA 0,91409528 0,9755605

5 TRAT1 CD3G CD6 CTLA4 CD5 NA NA NA NA NA 0,9217647 0,9754678

6 CD3D TRAT1 SIRPG CD3G CD5 CD28 NA NA NA NA 0,91762933 0,9754676

6 CD3D CD3G ICOS CD6 CTLA4 CD5 NA NA NA NA 0,91398175 0,9752714

5 CD3D TRAT1 CD3G ICOS CD5 NA NA NA NA NA 0,91024164 0,9751472

4 CD3G CTLA4 CD5 CD28 NA NA NA NA NA NA 0,89745258 0,97492

4 SI PG CD3G CD6 CTLA4 NA NA NA NA NA NA 0,91160704 0,9747928

4 SIRPG CD6 CTLA4 CD5 NA NA NA NA NA NA 0,90605281 0,9747619

4 CD3D CD6 CD5 CD28 NA NA NA NA NA NA 0,90084186 0,9747426

2 ICOS THEMIS NA NA NA NA NA NA NA NA 0,85398393 0,9745742

6 CD3D CD3G CD6 CTLA4 CD5 CD28 NA NA NA NA 0,92004659 0,9745484

5 CD3D TRAT1 CD3G CD5 CD28 NA NA NA NA NA 0,91002577 0,9743370

4 CD3D SIRPG ICOS CD5 NA NA NA NA NA NA 0,897642 0,9737855

3 CD3G CD6 CTLA4 NA NA NA NA NA NA NA 0,89543335 0,9737449

3 TRAT1 SIRPG CD5 NA NA NA NA NA NA NA 0,89651721 0,9737307

5 CD3D TRAT1 SIRPG CD6 CD5 NA NA NA NA NA 0,91308088 0,9736067

4 SIRPG CD3G THEMIS CD5 NA NA NA NA NA NA 0,90294602 0,9735893

3 TRAT1 SIRPG CD3G NA NA NA NA NA NA NA 0,8900353 0,9735712

4 CD3D SIRPG CD3G ICOS NA NA NA NA NA NA 0,89541186 0,9735161

6 CD3D SIRPG CD3G ICOS CTLA4 CD5 NA NA NA NA 0,9139157 0,9735123

3 CD3D CD3G ICOS NA NA NA NA NA NA NA 0,88466977 0,9735109

4 CD3D SIRPG CD3G CD28 NA NA NA NA NA NA 0,90115481 0,9732793

5 TRAT1 SIRPG CD3G CTLA4 CD5 NA NA NA NA NA 0,91906219 0,9731320

2 TRAT1 CD3G NA NA NA NA NA NA NA NA 0,86880124 0,9730925

2 SIRPG CD6 NA NA NA NA NA NA NA NA 0,86311727 0,9728567

6 CD3D SIRPG CD3G CTLA4 CD5 CD28 NA NA NA NA 0,92146024 0,9728144

7 CD3D TRAT1 SIRPG CD3G CD6 CTLA4 CD5 NA NA NA 0,92611962 0,972706

4 CD3D TRAT1 CD6 CD5 NA NA NA NA NA NA 0,90631251 0,9725037

6 CD3D SIRPG CD3G CD6 THEMIS CD5 NA NA NA NA 0,91376148 0,9722838

5 CD3D CD3G ICOS CTLA4 CD5 NA NA NA NA NA 0,90773874 0,9721858

5 CD3D TRAT1 SIRPG CD3G CD6 NA NA NA NA NA 0,91107295 0,9721025

3 CD3D ICOS CD5 NA NA NA NA NA NA NA 0,88774442 0,9718924

3 CD6 CTLA4 CD5 NA NA NA NA NA NA NA 0,88385447 0,9718880

5 SI PG CD3G CD6 CD5 CD28 NA NA NA NA NA 0,90978939 0,9717654

4 CD3D SIRPG CD5 CD28 NA NA NA NA NA NA 0,90847876 0,9717145

6 CD3D TRAT1 CD3G CD6 CTLA4 CD5 NA NA NA NA 0,92229188 0,9715251

3 CD3G THEMIS CD5 NA NA NA NA NA NA NA 0,88459886 0,9714433

4 CD3D TRAT1 CD3G CD6 NA NA NA NA NA NA 0,90394695 0,9713312

5 SIRPG CD3G ICOS CD6 CD5 NA NA NA NA NA 0,90195121 0,9712998

3 SIRPG CD3G CTLA4 NA NA NA NA NA NA NA 0,89058071 0,9711881

4 TRAT1 CD3G CTLA4 CD5 NA NA NA NA NA NA 0,9110829 0,9711492

5 CD3D CD3G CD6 THEMIS CD5 NA NA NA NA NA 0,90579188 0,9708715

2 CD5 CD28 NA NA NA NA NA NA NA NA 0,81623734 0,9708681

3 CD3D CD3G CD28 NA NA NA NA NA NA NA 0,88285975 0,9707257

5 CD3D CD3G CTLA4 CD5 CD28 NA NA NA NA NA 0,91289771 0,9706053

2 TRAT1 CD5 NA NA NA NA NA NA NA NA 0,88054338 0,9702737

1 THEMIS NA NA NA NA NA NA NA NA NA 0,77177102 0,9702152

4 CD3G ICOS CD6 CD5 NA NA NA NA NA NA 0,89127754 0,9701756

5 CD3D SIRPG CD6 CTLA4 CD5 NA NA NA NA NA 0,91540292 0,9701162

5 CD3D SIRPG CD3G CD6 CTLA4 NA NA NA NA NA 0,91490551 0,9697004

4 CD3G CD6 CD5 CD28 NA NA NA NA NA NA 0,89108042 0,9695485

6 CD3D TRAT1 SIRPG CD3G CTLA4 CD5 NA NA NA NA 0,92172913 0,9694958

5 CD3D SIRPG CD3G THEMIS CD5 NA NA NA NA NA 0,90982508 0,9688432

1 CD6 NA NA NA NA NA NA NA NA NA 0,77633836 0,9688131

3 SI PG CTLA4 CD5 NA NA NA NA NA NA NA 0,89000013 0,9686930

4 CD3D TRAT1 SIRPG CD5 NA NA NA NA NA NA 0,90884803 0,9685753

4 CD3D TRAT1 SIRPG CD3G NA NA NA NA NA NA 0,90187901 0,9678856

2 CD3G CTLA4 NA NA NA NA NA NA NA NA 0,85868078 0,967761

4 CD3D CD3G CD6 CTLA4 NA NA NA NA NA NA 0,90625371 0,9674387

6 CD3D SIRPG CD3G CD6 CD5 CD28 NA NA NA NA 0,91373703 0,9673669

5 CD3D TRAT1 CD3G CTLA4 CD5 NA NA NA NA NA 0,91705403 0,9672181

6 CD3D SIRPG CD3G ICOS CD6 CD5 NA NA NA NA 0,90555349 0,967143

4 CD3D CD6 CTLA4 CD5 NA NA NA NA NA NA 0,90612359 0,9669844

3 CD3D CD5 CD28 NA NA NA NA NA NA NA 0,89172456 0,9668228

3 CD3D SIRPG CD6 NA NA NA NA NA NA NA 0,89078802 0,9666731

5 TRAT1 SIRPG CD3G CD6 CD5 NA NA NA NA NA 0,91029422 0,966653

4 CD3D CD3G THEMIS CD5 NA NA NA NA NA NA 0,9006474 0,9659985

4 SI PG CD3G ICOS CD5 NA NA NA NA NA NA 0,89511531 0,9657860

4 SIRPG CD3G CD5 CD28 NA NA NA NA NA NA 0,90040983 0,9655224

3 CD3D TRAT1 CD3G NA NA NA NA NA NA NA 0,89203842 0,96526

4 CD3D SIRPG CD3G CTLA4 NA NA NA NA NA NA 0,90576546 0,9651720

5 CD3D CD3G ICOS CD6 CD5 NA NA NA NA NA 0,8983304 0,9650833

3 CD3D TRAT1 CD5 NA NA NA NA NA NA NA 0,90203564 0,9647589

5 CD3D CD3G CD6 CD5 CD28 NA NA NA NA NA 0,90381097 0,9645368

4 CD3D SIRPG CTLA4 CD5 NA NA NA NA NA NA 0,91035655 0,9642743

4 TRAT1 CD3G CD6 CD5 NA NA NA NA NA NA 0,90143206 0,9639699

5 SIRPG CD3G CD6 CTLA4 CD5 NA NA NA NA NA 0,91353824 0,9639211

6 CD3D TRAT1 SIRPG CD3G CD6 CD5 NA NA NA NA 0,91218919 0,9629995

2 CD3D CD6 NA NA NA NA NA NA NA NA 0,87002645 0,9619423

3 CD3G ICOS CD5 NA NA NA NA NA NA NA 0,8839151 0,9617800

5 CD3D SIRPG CD3G ICOS CD5 NA NA NA NA NA 0,90168085 0,9616903

5 CD3D SIRPG CD3G CD5 CD28 NA NA NA NA NA 0,90957836 0,9613917

1 SIRPG NA NA NA NA NA NA NA NA NA 0,79473659 0,9605313

6 CD3D SIRPG CD3G CD6 CTLA4 CD5 NA NA NA NA 0,91624151 0,9604055

3 CD3D CD3G CTLA4 NA NA NA NA NA NA NA 0,89356702 0,9603486

5 CD3D TRAT1 CD3G CD6 CD5 NA NA NA NA NA 0,90609266 0,959812

2 CTLA4 CD5 NA NA NA NA NA NA NA NA 0,8518487 0,9598062

4 CD3G CD6 CTLA4 CD5 NA NA NA NA NA NA 0,90151529 0,9596244

3 CD3G CD5 CD28 NA NA NA NA NA NA NA 0,87321835 0,9596148

4 T AT1 SIRPG CD3G CD5 NA NA NA NA NA NA 0,90362873 0,9592698

3 CD3D CTLA4 CD5 NA NA NA NA NA NA NA 0,89915312 0,9572540

4 CD3D CD3G ICOS CD5 NA NA NA NA NA NA 0,89413823 0,9572204

3 SIRPG CD6 CD5 NA NA NA NA NA NA NA 0,85452039 0,9568704

5 CD3D TRAT1 SIRPG CD3G CD5 NA NA NA NA NA 0,90858693 0,9562104

5 CD3D CD3G CD6 CTLA4 CD5 NA NA NA NA NA 0,90917968 0,9559899

4 SIRPG CD3G CTLA4 CD5 NA NA NA NA NA NA 0,90606871 0,9559779

4 CD3D CD3G CD5 CD28 NA NA NA NA NA NA 0,89774283 0,9557348

2 CD3D SIRPG NA NA NA NA NA NA NA NA 0,87813176 0,9554221

5 CD3D SIRPG CD3G CTLA4 CD5 NA NA NA NA NA 0,91271286 0,9531333

4 CD3D SIRPG CD6 CD5 NA NA NA NA NA NA 0,88777896 0,9528461

3 TRAT1 CD3G CD5 NA NA NA NA NA NA NA 0,89361881 0,9524642

3 SIRPG CD3G CD6 NA NA NA NA NA NA NA 0,87758756 0,9523260

4 CD3D TRAT1 CD3G CD5 NA NA NA NA NA NA 0,90216191 0,9499404

4 CD3D SIRPG CD3G CD6 NA NA NA NA NA NA 0,89178684 0,9492

3 CD3G CTLA4 CD5 NA NA NA NA NA NA NA 0,89004894 0,9466508

4 CD3D CD3G CTLA4 CD5 NA NA NA NA NA NA 0,90474098 0,9450782

2 CD6 CD5 NA NA NA NA NA NA NA NA 0,78701543 0,9439091

3 CD3D CD6 CD5 NA NA NA NA NA NA NA 0,86840222 0,9419321

4 SIRPG CD3G CD6 CD5 NA NA NA NA NA NA 0,87587234 0,9406027

5 CD3D SIRPG CD3G CD6 CD5 NA NA NA NA NA 0,89178429 0,9397672

2 CD3G CD6 NA NA NA NA NA NA NA NA 0,84058253 0,9387021

3 CD3D CD3G CD6 NA NA NA NA NA NA NA 0,87584062 0,937667

3 CD3D SIRPG CD5 NA NA NA NA NA NA NA 0,8843147 0,9351830

2 SI PG CD5 NA NA NA NA NA NA NA NA 0,83355431 0,9322595

3 CD3D SIRPG CD3G NA NA NA NA NA NA NA 0,88195224 0,9319522

1 CD3D NA NA NA NA NA NA NA NA NA 0,85065552 0,9309479

2 SIRPG CD3G NA NA NA NA NA NA NA NA 0,85086565 0,9287224

4 CD3D CD3G CD6 CD5 NA NA NA NA NA NA 0,87778458 0,9269222

3 CD3G CD6 CD5 NA NA NA NA NA NA NA 0,84517943 0,9243184

4 CD3D SIRPG CD3G CD5 NA NA NA NA NA NA 0,88838991 0,9218404

3 SIRPG CD3G CD5 NA NA NA NA NA NA NA 0,86705711 0,9167172

2 CD3D CD5 NA NA NA NA NA NA NA NA 0,86398414 0,9042934

2 CD3D CD3G NA NA NA NA NA NA NA NA 0,86133762 0,9002737

3 CD3D CD3G CD5 NA NA NA NA NA NA NA 0,87329721 0,8952003

2 CD3G CD5 NA NA NA NA NA NA NA NA 0,82813417 0,8734702

1 CD5 NA NA NA NA NA NA NA NA NA 0,71218117 0,8661944

1 CD3G NA NA NA NA NA NA NA NA NA 0,780051 0,8615626

REFERENCES:

Throughout this application, various references describe the state of the art to which this invention pertains. The disclosures of these references are hereby incorporated by reference into the present disclosure.

Claims

CLAIMS:
1. A method for quantifying the population of neutrophils in a tissue sample obtained from a subject comprising determining the expression level of at least one gene selected from the group consisting of CXCR2, VNN3, CYP4F3, HAL, GENE 1, FCGR3B, KCNJ15, CXCR1, STEAP4 and TNFRSF10C wherein the determined expression level indicates the quantity of the population of myeloid dendritic cells in the tissue sample.
2. The method of claim 1 wherein the subject suffers from a cancer.
3. The method of claim 2 wherein the subject suffers from a solid cancer selected from the group consisting of bile duct cancer (e.g. periphilar cancer, distal bile duct cancer, intrahepatic bile duct cancer), bladder cancer, bone cancer (e.g. osteoblastoma, osteochrondroma, hemangioma, chondromyxoid fibroma, osteosarcoma, chondrosarcoma, fibrosarcoma, malignant fibrous histiocytoma, giant cell tumor of the bone, chordoma, lymphoma, multiple myeloma), brain and central nervous system cancer (e.g. meningioma, astocytoma, oligodendrogliomas, ependymoma, gliomas, medulloblastoma, ganglioglioma, Schwannoma, germinoma, craniopharyngioma), breast cancer (e.g. ductal carcinoma in situ, infiltrating ductal carcinoma, infiltrating, lobular carcinoma, lobular carcinoma in, situ, gynecomastia), Castleman disease (e.g. giant lymph node hyperplasia, angiofollicular lymph node hyperplasia), cervical cancer, colorectal cancer, endometrial cancer (e.g. endometrial adenocarcinoma, adenocanthoma, papillary serous adnocarcinroma, clear cell), esophagus cancer, gallbladder cancer (mucinous adenocarcinoma, small cell carcinoma), gastrointestinal carcinoid tumors (e.g. choriocarcinoma, chorioadenoma destruens), Hodgkin's disease, non-Hodgkin's lymphoma, Kaposi's sarcoma, kidney cancer (e.g. renal cell cancer), laryngeal and hypopharyngeal cancer, liver cancer (e.g. hemangioma, hepatic adenoma, focal nodular hyperplasia, hepatocellular carcinoma), lung cancer (e.g. small cell lung cancer, non-small cell lung cancer), mesothelioma, plasmacytoma, nasal cavity and paranasal sinus cancer (e.g. esthesioneuroblastoma, midline granuloma), nasopharyngeal cancer, neuroblastoma, oral cavity and oropharyngeal cancer, ovarian cancer, pancreatic cancer, penile cancer, pituitary cancer, prostate cancer, retinoblastoma, rhabdomyosarcoma (e.g. embryonal rhabdomyosarcoma, alveolar rhabdomyosarcoma, pleomorphic rhabdomyosarcoma), salivary gland cancer, skin cancer (e.g. melanoma, nonmelanoma skin cancer), stomach cancer, testicular cancer (e.g. seminoma, nonseminoma germ cell cancer), thymus cancer, thyroid cancer (e.g. follicular carcinoma, anaplastic carcinoma, poorly differentiated carcinoma, medullary thyroid carcinoma, thyroid lymphoma), vaginal cancer, vulvar cancer, and uterine cancer (e.g. uterine leiomyosarcoma).
4. The method of claim 1 wherein the expression level of 2, 3, 4, 5, 6, 7, 8, 9 or 10 genes is determined at step i).
5. The method of claim 4 wherein the combination of genes is selected from the Table 1.
6. The method of claim 1 which further comprises quantifying at least one further population of cells in the tissue sample.
7. The method of claim 6 wherein the at least one population of cells is selected from the group consisting of B cells, T cells, NK cells, cytotoxic lymphocytes, myeloid dendritic cells, cells of monocytic origin (includes monocytes, macrophages, dendritic cells), fibroblasts and endothelial cells (includes lymphatics and blood vessels).
8. The method of claim 1 which further comprises determining the expression level of at least one gene representative of B cells selected from the group consisting of MS4A1, CD19, CD79A, FCRL2, CR2, PAX5, CD22, BANK1 and IGKC.
9. The method of claim 1 which further comprises determining the expression level of at least one gene representative of T cells selected from the group consisting of TRATl, CD3D, THEMIS, ICOS, SIRPG, CD3G, CTLA4, CD6, CD5 and CD28.
10. The method of claim 1 which further comprises determining the expression level of at least one gene representative of NK cells selected from the group consisting of KIR2DL1, KIR2DL3, NCR1, KIR3DL1, KIR3DS1, KIR3DL2, SH2D1B, CD160, GENE 2 and KIR2DL4.
11. The method of claim 1 which further comprises determining the expression level of at least one gene representative of cytotoxic lymphocytes selected from the group consisting of KLRC4-KLRK1 /// KLRKl, CD8A, KLRDl, GNLY, EOMES, KLRC3, KLRC4, FGFBP2 and KLRCl /// KLRC2.
12. The method of claim 1 which further comprises determining the expression level of at least one gene representative of myeloid dendritic cells selected from the group consisting of CD1E, CLECIOA, CLIC2, CD1A, WFDC21P and CD1B.
13. The method of claim 1 which further comprises determining the expression level of at least one gene representative of cells of monocytic origin selected from the group consisting of CSF1R, ADAP2, RASSF4, FPR3, TFEC, PLA2G7 and KYNU.
14. The method of claim 1 which further comprises determining the expression level of at least one gene representative of fibroblasts selected from the group consisting of DCN, COL6A2, COL6A1, COL3A1, COL1A1, PAMR1, TAGLN and GREM1.
15. The method of claim 1 which further comprises determining the expression level of at least one gene representative of endothelial cells selected from the group consisting of CDH5, EMCN, MYCT1, ELTD1, ROB04, CLEC14A, VWF, ESAM, MMRN2 and KDR.
PCT/EP2016/073053 2015-09-29 2016-09-28 Methods for quantifying the population of neutrophils in a tissue sample WO2017055322A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EPEP15306521.4 2015-09-29
EP15306521 2015-09-29
EP16305886 2016-07-12
EPEP16305886.0 2016-07-12

Publications (1)

Publication Number Publication Date
WO2017055322A1 true WO2017055322A1 (en) 2017-04-06

Family

ID=57047213

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2016/073053 WO2017055322A1 (en) 2015-09-29 2016-09-28 Methods for quantifying the population of neutrophils in a tissue sample

Country Status (1)

Country Link
WO (1) WO2017055322A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019125184A1 (en) 2017-12-19 2019-06-27 Auckland Uniservices Limited Use of biomarker in cancer therapy

Citations (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4690915A (en) 1985-08-08 1987-09-01 The United States Of America As Represented By The Department Of Health And Human Services Adoptive immunotherapy as a treatment modality in humans
US4774339A (en) 1987-08-10 1988-09-27 Molecular Probes, Inc. Chemically reactive dipyrrometheneboron difluoride dyes
US4888278A (en) 1985-10-22 1989-12-19 University Of Massachusetts Medical Center In-situ hybridization to detect nucleic acid sequences in morphologically intact cells
US5132432A (en) 1989-09-22 1992-07-21 Molecular Probes, Inc. Chemically reactive pyrenyloxy sulfonic acid dyes
US5187288A (en) 1991-05-22 1993-02-16 Molecular Probes, Inc. Ethenyl-substituted dipyrrometheneboron difluoride dyes and their synthesis
US5248782A (en) 1990-12-18 1993-09-28 Molecular Probes, Inc. Long wavelength heteroaryl-substituted dipyrrometheneboron difluoride dyes
US5262357A (en) 1991-11-22 1993-11-16 The Regents Of The University Of California Low temperature thin films formed from nanocrystal precursors
US5274113A (en) 1991-11-01 1993-12-28 Molecular Probes, Inc. Long wavelength chemically reactive dipyrrometheneboron difluoride dyes and conjugates
US5338854A (en) 1991-02-13 1994-08-16 Molecular Probes, Inc. Fluorescent fatty acids derived from dipyrrometheneboron difluoride dyes
US5427932A (en) 1991-04-09 1995-06-27 Reagents Of The University Of California Repeat sequence chromosome specific nucleic acid probes and methods of preparing and using
US5433896A (en) 1994-05-20 1995-07-18 Molecular Probes, Inc. Dibenzopyrrometheneboron difluoride dyes
US5447841A (en) 1986-01-16 1995-09-05 The Regents Of The Univ. Of California Methods for chromosome-specific staining
US5472842A (en) 1993-10-06 1995-12-05 The Regents Of The University Of California Detection of amplified or deleted chromosomal regions
US5505928A (en) 1991-11-22 1996-04-09 The Regents Of University Of California Preparation of III-V semiconductor nanocrystals
US5571018A (en) 1994-11-23 1996-11-05 Motorola, Inc. Arrangement for simulating indirect fire in combat training
US5618829A (en) 1993-01-28 1997-04-08 Mitsubishi Chemical Corporation Tyrosine kinase inhibitors and benzoylacrylamide derivatives
US5639757A (en) 1995-05-23 1997-06-17 Pfizer Inc. 4-aminopyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors
US5690807A (en) 1995-08-03 1997-11-25 Massachusetts Institute Of Technology Method for producing semiconductor particles
US5696157A (en) 1996-11-15 1997-12-09 Molecular Probes, Inc. Sulfonated derivatives of 7-aminocoumarin
US5728868A (en) 1993-07-15 1998-03-17 Cancer Research Campaign Technology Limited Prodrugs of protein tyrosine kinase inhibitors
US5800996A (en) 1996-05-03 1998-09-01 The Perkin Elmer Corporation Energy transfer dyes with enchanced fluorescence
US5804396A (en) 1994-10-12 1998-09-08 Sugen, Inc. Assay for agents active in proliferative disorders
US5811097A (en) 1995-07-25 1998-09-22 The Regents Of The University Of California Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
WO1998045331A2 (en) 1997-04-07 1998-10-15 Genentech, Inc. Anti-vegf antibodies
US5830912A (en) 1996-11-15 1998-11-03 Molecular Probes, Inc. Derivatives of 6,8-difluoro-7-hydroxycoumarin
US5855887A (en) 1995-07-25 1999-01-05 The Regents Of The University Of California Blockade of lymphocyte down-regulation associated with CTLA-4 signaling
US5866366A (en) 1997-07-01 1999-02-02 Smithkline Beecham Corporation gidB
US5990479A (en) 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6048616A (en) 1993-04-21 2000-04-11 Philips Electronics N.A. Corp. Encapsulated quantum sized doped semiconductor particles and method of manufacturing same
US6051227A (en) 1995-07-25 2000-04-18 The Regents Of The University Of California, Office Of Technology Transfer Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
US6100254A (en) 1997-10-10 2000-08-08 Board Of Regents, The University Of Texas System Inhibitors of protein tyrosine kinases
US6114038A (en) 1998-11-10 2000-09-05 Biocrystal Ltd. Functionalized nanocrystals and their use in detection systems
US6127374A (en) 1997-07-29 2000-10-03 Warner-Lambert Company Irreversible inhibitors of tyrosine kinases
US6130101A (en) 1997-09-23 2000-10-10 Molecular Probes, Inc. Sulfonated xanthene derivatives
US6207157B1 (en) 1996-04-23 2001-03-27 The United States Of America As Represented By The Department Of Health And Human Services Conjugate vaccine for nontypeable Haemophilus influenzae
US6207392B1 (en) 1997-11-25 2001-03-27 The Regents Of The University Of California Semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6225198B1 (en) 2000-02-04 2001-05-01 The Regents Of The University Of California Process for forming shaped group II-VI semiconductor nanocrystals, and product formed using process
US6245759B1 (en) 1999-03-11 2001-06-12 Merck & Co., Inc. Tyrosine kinase inhibitors
US6274323B1 (en) 1999-05-07 2001-08-14 Quantum Dot Corporation Method of detecting an analyte in a sample using semiconductor nanocrystals as a detectable label
US6280929B1 (en) 1986-01-16 2001-08-28 The Regents Of The University Of California Method of detecting genetic translocations identified with chromosomal abnormalities
US6306736B1 (en) 2000-02-04 2001-10-23 The Regents Of The University Of California Process for forming shaped group III-V semiconductor nanocrystals, and product formed using process
US6306874B1 (en) 1999-10-19 2001-10-23 Merck & Co., Inc. Tyrosine kinase inhibitors
US6313138B1 (en) 2000-02-25 2001-11-06 Merck & Co., Inc. Tyrosine kinase inhibitors
US6316444B1 (en) 1999-06-30 2001-11-13 Merck & Co., Inc. SRC kinase inhibitor compounds
US6329380B1 (en) 1999-06-30 2001-12-11 Merck & Co., Inc. SRC kinase inhibitor compounds
US6344459B1 (en) 1996-04-12 2002-02-05 Warner-Lambert Company Irreversible inhibitors of tyrosine kinases
US6420382B2 (en) 2000-02-25 2002-07-16 Merck & Co., Inc. Tyrosine kinase inhibitors
US6479512B1 (en) 1999-10-19 2002-11-12 Merck & Co., Inc. Tyrosine kinase inhibitors
US6498165B1 (en) 1999-06-30 2002-12-24 Merck & Co., Inc. Src kinase inhibitor compounds
US6500622B2 (en) 2000-03-22 2002-12-31 Quantum Dot Corporation Methods of using semiconductor nanocrystals in bead-based nucleic acid assays
WO2003042402A2 (en) 2001-11-13 2003-05-22 Dana-Farber Cancer Institute, Inc. Agents that modulate immune cell activation and methods of use thereof
US6586424B2 (en) 1999-09-10 2003-07-01 Merck & Co., Inc. Tyrosine kinase inhibitors
US6602671B1 (en) 1998-09-18 2003-08-05 Massachusetts Institute Of Technology Semiconductor nanocrystals for inventory control
US20030170238A1 (en) 2002-03-07 2003-09-11 Gruenberg Micheal L. Re-activated T-cells for adoptive immunotherapy
US20030190317A1 (en) 1997-04-07 2003-10-09 Genentech, Inc. Anti-VEGF antibodies
US6649138B2 (en) 2000-10-13 2003-11-18 Quantum Dot Corporation Surface-modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media
US6670113B2 (en) 2001-03-30 2003-12-30 Nanoprobes Enzymatic deposition and alteration of metals
US6682596B2 (en) 2000-12-28 2004-01-27 Quantum Dot Corporation Flow synthesis of quantum dot nanocrystals
US6682736B1 (en) 1998-12-23 2004-01-27 Abgenix, Inc. Human monoclonal antibodies to CTLA-4
US6689338B2 (en) 2000-06-01 2004-02-10 The Board Of Regents For Oklahoma State University Bioconjugates of nanoparticles as radiopharmaceuticals
US6709929B2 (en) 2001-06-25 2004-03-23 North Carolina State University Methods of forming nano-scale electronic and optoelectronic devices using non-photolithographically defined nano-channel templates
US6716979B2 (en) 2000-08-04 2004-04-06 Molecular Probes, Inc. Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings
US6740665B1 (en) 1999-02-10 2004-05-25 Ramachandran Murali Tyrosine kinase inhibitors and methods of using the same
US6794393B1 (en) 1999-10-19 2004-09-21 Merck & Co., Inc. Tyrosine kinase inhibitors
US6815064B2 (en) 2001-07-20 2004-11-09 Quantum Dot Corporation Luminescent nanoparticles and methods for their preparation
US20040265922A1 (en) 2003-06-24 2004-12-30 Ventana Medical Systems, Inc. Enzyme-catalyzed metal deposition for the enhanced in situ detection of immunohistochemical epitopes and nucleic acid sequences
US6855202B2 (en) 2001-11-30 2005-02-15 The Regents Of The University Of California Shaped nanocrystal particles and methods for making the same
US6875767B2 (en) 2001-06-22 2005-04-05 Merck & Co., Inc. (5-cyano-2-thiazolyl)amino-4-pyridine tyrosine kinase inhibitors
US20050100976A1 (en) 2003-06-24 2005-05-12 Christopher Bieniarz Enzyme-catalyzed metal deposition for the enhanced detection of analytes of interest
US6927293B2 (en) 2001-08-30 2005-08-09 Merck & Co., Inc. Tyrosine kinase inhibitors
US6942970B2 (en) 2000-09-14 2005-09-13 Zymed Laboratories, Inc. Identifying subjects suitable for topoisomerase II inhibitor treatment
US6958340B2 (en) 2001-08-01 2005-10-25 Merck & Co., Inc. Tyrosine kinase inhibitors
US6984720B1 (en) 1999-08-24 2006-01-10 Medarex, Inc. Human CTLA-4 antibodies
US20060246523A1 (en) 2005-04-28 2006-11-02 Christopher Bieniarz Antibody conjugates
US20060246524A1 (en) 2005-04-28 2006-11-02 Christina Bauer Nanoparticle conjugates
US20070117153A1 (en) 2005-11-23 2007-05-24 Christopher Bieniarz Molecular conjugate
WO2007076132A2 (en) 2005-12-23 2007-07-05 Nanostring Technologies, Inc. Compositions comprising oriented, immobilized macromolecules and methods for their preparation
WO2007076129A2 (en) 2005-12-23 2007-07-05 Nanostring Technologies, Inc. Nanoreporters and methods of manufacturing and use thereof
US20070254295A1 (en) 2006-03-17 2007-11-01 Prometheus Laboratories Inc. Methods of predicting and monitoring tyrosine kinase inhibitor therapy
WO2008124847A2 (en) 2007-04-10 2008-10-16 Nanostring Technologies, Inc. Methods and computer systems for identifying target-specific sequences for use in nanoreporters
WO2008156712A1 (en) 2007-06-18 2008-12-24 N. V. Organon Antibodies to human programmed death receptor pd-1
US7488802B2 (en) 2002-12-23 2009-02-10 Wyeth Antibodies against PD-1
US7605238B2 (en) 1999-08-24 2009-10-20 Medarex, Inc. Human CTLA-4 antibodies and their uses
EP2127666A1 (en) * 2008-05-28 2009-12-02 Drug Discovery Factory B.V. Method for the treatment or prophylaxis of chronic inflammatory diseases
WO2010019826A1 (en) 2008-08-14 2010-02-18 Nanostring Technologies, Inc Stable nanoreporters
WO2010036959A2 (en) 2008-09-26 2010-04-01 Dana-Farber Cancer Institute Human anti-pd-1, pd-l1, and pd-l2 antibodies and uses therefor
WO2010089411A2 (en) 2009-02-09 2010-08-12 Universite De La Mediterranee Pd-1 antibodies and pd-l1 antibodies and uses thereof
US7943743B2 (en) 2005-07-01 2011-05-17 Medarex, Inc. Human monoclonal antibodies to programmed death ligand 1 (PD-L1)
WO2011066342A2 (en) 2009-11-24 2011-06-03 Amplimmune, Inc. Simultaneous inhibition of pd-l1/pd-l2
WO2011082400A2 (en) 2010-01-04 2011-07-07 President And Fellows Of Harvard College Modulators of immunoinhibitory receptor pd-1, and methods of use thereof
US8008449B2 (en) 2005-05-09 2011-08-30 Medarex, Inc. Human monoclonal antibodies to programmed death 1 (PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics
WO2011159877A2 (en) 2010-06-18 2011-12-22 The Brigham And Women's Hospital, Inc. Bi-specific antibodies against tim-3 and pd-1 for immunotherapy in chronic immune conditions
WO2011161699A2 (en) 2010-06-25 2011-12-29 Aurigene Discovery Technologies Limited Immunosuppression modulating compounds
US8168757B2 (en) 2008-03-12 2012-05-01 Merck Sharp & Dohme Corp. PD-1 binding proteins
US8217149B2 (en) 2008-12-09 2012-07-10 Genentech, Inc. Anti-PD-L1 antibodies, compositions and articles of manufacture
US9926299B2 (en) 2012-11-30 2018-03-27 Centaurus Biopharma Co., Ltd. Inhibitors of bruton's tyrosine kinase

Patent Citations (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4690915A (en) 1985-08-08 1987-09-01 The United States Of America As Represented By The Department Of Health And Human Services Adoptive immunotherapy as a treatment modality in humans
US4888278A (en) 1985-10-22 1989-12-19 University Of Massachusetts Medical Center In-situ hybridization to detect nucleic acid sequences in morphologically intact cells
US6280929B1 (en) 1986-01-16 2001-08-28 The Regents Of The University Of California Method of detecting genetic translocations identified with chromosomal abnormalities
US5447841A (en) 1986-01-16 1995-09-05 The Regents Of The Univ. Of California Methods for chromosome-specific staining
US4774339A (en) 1987-08-10 1988-09-27 Molecular Probes, Inc. Chemically reactive dipyrrometheneboron difluoride dyes
US5132432A (en) 1989-09-22 1992-07-21 Molecular Probes, Inc. Chemically reactive pyrenyloxy sulfonic acid dyes
US5248782A (en) 1990-12-18 1993-09-28 Molecular Probes, Inc. Long wavelength heteroaryl-substituted dipyrrometheneboron difluoride dyes
US5338854A (en) 1991-02-13 1994-08-16 Molecular Probes, Inc. Fluorescent fatty acids derived from dipyrrometheneboron difluoride dyes
US5427932A (en) 1991-04-09 1995-06-27 Reagents Of The University Of California Repeat sequence chromosome specific nucleic acid probes and methods of preparing and using
US5187288A (en) 1991-05-22 1993-02-16 Molecular Probes, Inc. Ethenyl-substituted dipyrrometheneboron difluoride dyes and their synthesis
US5274113A (en) 1991-11-01 1993-12-28 Molecular Probes, Inc. Long wavelength chemically reactive dipyrrometheneboron difluoride dyes and conjugates
US5451663A (en) 1991-11-01 1995-09-19 Molecular Probes, Inc. Long wavelength chemically reactive dipyrrometheneboron difluoride dyes and conjugates
US5262357A (en) 1991-11-22 1993-11-16 The Regents Of The University Of California Low temperature thin films formed from nanocrystal precursors
US5505928A (en) 1991-11-22 1996-04-09 The Regents Of University Of California Preparation of III-V semiconductor nanocrystals
US5618829A (en) 1993-01-28 1997-04-08 Mitsubishi Chemical Corporation Tyrosine kinase inhibitors and benzoylacrylamide derivatives
US6048616A (en) 1993-04-21 2000-04-11 Philips Electronics N.A. Corp. Encapsulated quantum sized doped semiconductor particles and method of manufacturing same
US5728868A (en) 1993-07-15 1998-03-17 Cancer Research Campaign Technology Limited Prodrugs of protein tyrosine kinase inhibitors
US5472842A (en) 1993-10-06 1995-12-05 The Regents Of The University Of California Detection of amplified or deleted chromosomal regions
US5433896A (en) 1994-05-20 1995-07-18 Molecular Probes, Inc. Dibenzopyrrometheneboron difluoride dyes
US5804396A (en) 1994-10-12 1998-09-08 Sugen, Inc. Assay for agents active in proliferative disorders
US5571018A (en) 1994-11-23 1996-11-05 Motorola, Inc. Arrangement for simulating indirect fire in combat training
US5639757A (en) 1995-05-23 1997-06-17 Pfizer Inc. 4-aminopyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors
US6051227A (en) 1995-07-25 2000-04-18 The Regents Of The University Of California, Office Of Technology Transfer Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
US5811097A (en) 1995-07-25 1998-09-22 The Regents Of The University Of California Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
US5855887A (en) 1995-07-25 1999-01-05 The Regents Of The University Of California Blockade of lymphocyte down-regulation associated with CTLA-4 signaling
US5690807A (en) 1995-08-03 1997-11-25 Massachusetts Institute Of Technology Method for producing semiconductor particles
US6344459B1 (en) 1996-04-12 2002-02-05 Warner-Lambert Company Irreversible inhibitors of tyrosine kinases
US6207157B1 (en) 1996-04-23 2001-03-27 The United States Of America As Represented By The Department Of Health And Human Services Conjugate vaccine for nontypeable Haemophilus influenzae
US5800996A (en) 1996-05-03 1998-09-01 The Perkin Elmer Corporation Energy transfer dyes with enchanced fluorescence
US5830912A (en) 1996-11-15 1998-11-03 Molecular Probes, Inc. Derivatives of 6,8-difluoro-7-hydroxycoumarin
US5696157A (en) 1996-11-15 1997-12-09 Molecular Probes, Inc. Sulfonated derivatives of 7-aminocoumarin
US20030190317A1 (en) 1997-04-07 2003-10-09 Genentech, Inc. Anti-VEGF antibodies
WO1998045331A2 (en) 1997-04-07 1998-10-15 Genentech, Inc. Anti-vegf antibodies
US5866366A (en) 1997-07-01 1999-02-02 Smithkline Beecham Corporation gidB
US6127374A (en) 1997-07-29 2000-10-03 Warner-Lambert Company Irreversible inhibitors of tyrosine kinases
US6562818B1 (en) 1997-07-29 2003-05-13 Warner-Lambert Company Irreversible inhibitors of tyrosine kinases
US6130101A (en) 1997-09-23 2000-10-10 Molecular Probes, Inc. Sulfonated xanthene derivatives
US6100254A (en) 1997-10-10 2000-08-08 Board Of Regents, The University Of Texas System Inhibitors of protein tyrosine kinases
US6207392B1 (en) 1997-11-25 2001-03-27 The Regents Of The University Of California Semiconductor nanocrystal probes for biological applications and process for making and using such probes
US5990479A (en) 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6927069B2 (en) 1997-11-25 2005-08-09 The Regents Of The University Of California Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6602671B1 (en) 1998-09-18 2003-08-05 Massachusetts Institute Of Technology Semiconductor nanocrystals for inventory control
US6114038A (en) 1998-11-10 2000-09-05 Biocrystal Ltd. Functionalized nanocrystals and their use in detection systems
US6682736B1 (en) 1998-12-23 2004-01-27 Abgenix, Inc. Human monoclonal antibodies to CTLA-4
US6740665B1 (en) 1999-02-10 2004-05-25 Ramachandran Murali Tyrosine kinase inhibitors and methods of using the same
US6245759B1 (en) 1999-03-11 2001-06-12 Merck & Co., Inc. Tyrosine kinase inhibitors
US6544988B1 (en) 1999-03-11 2003-04-08 Merck & Co., Inc. Tyrosine kinase inhibitors
US6274323B1 (en) 1999-05-07 2001-08-14 Quantum Dot Corporation Method of detecting an analyte in a sample using semiconductor nanocrystals as a detectable label
US6316444B1 (en) 1999-06-30 2001-11-13 Merck & Co., Inc. SRC kinase inhibitor compounds
US6329380B1 (en) 1999-06-30 2001-12-11 Merck & Co., Inc. SRC kinase inhibitor compounds
US6498165B1 (en) 1999-06-30 2002-12-24 Merck & Co., Inc. Src kinase inhibitor compounds
US7605238B2 (en) 1999-08-24 2009-10-20 Medarex, Inc. Human CTLA-4 antibodies and their uses
US6984720B1 (en) 1999-08-24 2006-01-10 Medarex, Inc. Human CTLA-4 antibodies
US6586424B2 (en) 1999-09-10 2003-07-01 Merck & Co., Inc. Tyrosine kinase inhibitors
US6586423B2 (en) 1999-09-10 2003-07-01 Merck & Co., Inc. Tyrosine kinase inhibitors
US6794393B1 (en) 1999-10-19 2004-09-21 Merck & Co., Inc. Tyrosine kinase inhibitors
US6306874B1 (en) 1999-10-19 2001-10-23 Merck & Co., Inc. Tyrosine kinase inhibitors
US6479512B1 (en) 1999-10-19 2002-11-12 Merck & Co., Inc. Tyrosine kinase inhibitors
US6306736B1 (en) 2000-02-04 2001-10-23 The Regents Of The University Of California Process for forming shaped group III-V semiconductor nanocrystals, and product formed using process
US6225198B1 (en) 2000-02-04 2001-05-01 The Regents Of The University Of California Process for forming shaped group II-VI semiconductor nanocrystals, and product formed using process
US6313138B1 (en) 2000-02-25 2001-11-06 Merck & Co., Inc. Tyrosine kinase inhibitors
US6420382B2 (en) 2000-02-25 2002-07-16 Merck & Co., Inc. Tyrosine kinase inhibitors
US20030165951A1 (en) 2000-03-22 2003-09-04 Quantum Dot Corporation Methods of using semiconductor nanocrystals in bead-based nucleic acid assays
US6500622B2 (en) 2000-03-22 2002-12-31 Quantum Dot Corporation Methods of using semiconductor nanocrystals in bead-based nucleic acid assays
US6689338B2 (en) 2000-06-01 2004-02-10 The Board Of Regents For Oklahoma State University Bioconjugates of nanoparticles as radiopharmaceuticals
US6716979B2 (en) 2000-08-04 2004-04-06 Molecular Probes, Inc. Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings
US6942970B2 (en) 2000-09-14 2005-09-13 Zymed Laboratories, Inc. Identifying subjects suitable for topoisomerase II inhibitor treatment
US6649138B2 (en) 2000-10-13 2003-11-18 Quantum Dot Corporation Surface-modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media
US6682596B2 (en) 2000-12-28 2004-01-27 Quantum Dot Corporation Flow synthesis of quantum dot nanocrystals
US6670113B2 (en) 2001-03-30 2003-12-30 Nanoprobes Enzymatic deposition and alteration of metals
US6875767B2 (en) 2001-06-22 2005-04-05 Merck & Co., Inc. (5-cyano-2-thiazolyl)amino-4-pyridine tyrosine kinase inhibitors
US6709929B2 (en) 2001-06-25 2004-03-23 North Carolina State University Methods of forming nano-scale electronic and optoelectronic devices using non-photolithographically defined nano-channel templates
US6914256B2 (en) 2001-06-25 2005-07-05 North Carolina State University Optoelectronic devices having arrays of quantum-dot compound semiconductor superlattices therein
US6815064B2 (en) 2001-07-20 2004-11-09 Quantum Dot Corporation Luminescent nanoparticles and methods for their preparation
US6958340B2 (en) 2001-08-01 2005-10-25 Merck & Co., Inc. Tyrosine kinase inhibitors
US6927293B2 (en) 2001-08-30 2005-08-09 Merck & Co., Inc. Tyrosine kinase inhibitors
WO2003042402A2 (en) 2001-11-13 2003-05-22 Dana-Farber Cancer Institute, Inc. Agents that modulate immune cell activation and methods of use thereof
US6855202B2 (en) 2001-11-30 2005-02-15 The Regents Of The University Of California Shaped nanocrystal particles and methods for making the same
US20030170238A1 (en) 2002-03-07 2003-09-11 Gruenberg Micheal L. Re-activated T-cells for adoptive immunotherapy
US7488802B2 (en) 2002-12-23 2009-02-10 Wyeth Antibodies against PD-1
US20050100976A1 (en) 2003-06-24 2005-05-12 Christopher Bieniarz Enzyme-catalyzed metal deposition for the enhanced detection of analytes of interest
US20040265922A1 (en) 2003-06-24 2004-12-30 Ventana Medical Systems, Inc. Enzyme-catalyzed metal deposition for the enhanced in situ detection of immunohistochemical epitopes and nucleic acid sequences
US20060246524A1 (en) 2005-04-28 2006-11-02 Christina Bauer Nanoparticle conjugates
US20060246523A1 (en) 2005-04-28 2006-11-02 Christopher Bieniarz Antibody conjugates
US8008449B2 (en) 2005-05-09 2011-08-30 Medarex, Inc. Human monoclonal antibodies to programmed death 1 (PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics
US7943743B2 (en) 2005-07-01 2011-05-17 Medarex, Inc. Human monoclonal antibodies to programmed death ligand 1 (PD-L1)
US20070117153A1 (en) 2005-11-23 2007-05-24 Christopher Bieniarz Molecular conjugate
WO2007076129A2 (en) 2005-12-23 2007-07-05 Nanostring Technologies, Inc. Nanoreporters and methods of manufacturing and use thereof
US20100261026A1 (en) 2005-12-23 2010-10-14 Nanostring Technologies, Inc. Compositions comprising oriented, immobilized macromolecules and methods for their preparation
WO2007076132A2 (en) 2005-12-23 2007-07-05 Nanostring Technologies, Inc. Compositions comprising oriented, immobilized macromolecules and methods for their preparation
US20100015607A1 (en) 2005-12-23 2010-01-21 Nanostring Technologies, Inc. Nanoreporters and methods of manufacturing and use thereof
US20070254295A1 (en) 2006-03-17 2007-11-01 Prometheus Laboratories Inc. Methods of predicting and monitoring tyrosine kinase inhibitor therapy
WO2008124847A2 (en) 2007-04-10 2008-10-16 Nanostring Technologies, Inc. Methods and computer systems for identifying target-specific sequences for use in nanoreporters
US8415102B2 (en) 2007-04-10 2013-04-09 Nanostring Technologies, Inc. Methods and computer systems for identifying target-specific sequences for use in nanoreporters
WO2008156712A1 (en) 2007-06-18 2008-12-24 N. V. Organon Antibodies to human programmed death receptor pd-1
US8168757B2 (en) 2008-03-12 2012-05-01 Merck Sharp & Dohme Corp. PD-1 binding proteins
EP2127666A1 (en) * 2008-05-28 2009-12-02 Drug Discovery Factory B.V. Method for the treatment or prophylaxis of chronic inflammatory diseases
WO2010019826A1 (en) 2008-08-14 2010-02-18 Nanostring Technologies, Inc Stable nanoreporters
US20100047924A1 (en) 2008-08-14 2010-02-25 Nanostring Technologies, Inc. Stable nanoreporters
WO2010036959A2 (en) 2008-09-26 2010-04-01 Dana-Farber Cancer Institute Human anti-pd-1, pd-l1, and pd-l2 antibodies and uses therefor
US8217149B2 (en) 2008-12-09 2012-07-10 Genentech, Inc. Anti-PD-L1 antibodies, compositions and articles of manufacture
WO2010089411A2 (en) 2009-02-09 2010-08-12 Universite De La Mediterranee Pd-1 antibodies and pd-l1 antibodies and uses thereof
WO2011066342A2 (en) 2009-11-24 2011-06-03 Amplimmune, Inc. Simultaneous inhibition of pd-l1/pd-l2
WO2011082400A2 (en) 2010-01-04 2011-07-07 President And Fellows Of Harvard College Modulators of immunoinhibitory receptor pd-1, and methods of use thereof
WO2011159877A2 (en) 2010-06-18 2011-12-22 The Brigham And Women's Hospital, Inc. Bi-specific antibodies against tim-3 and pd-1 for immunotherapy in chronic immune conditions
WO2011161699A2 (en) 2010-06-25 2011-12-29 Aurigene Discovery Technologies Limited Immunosuppression modulating compounds
US9926299B2 (en) 2012-11-30 2018-03-27 Centaurus Biopharma Co., Ltd. Inhibitors of bruton's tyrosine kinase

Non-Patent Citations (19)

* Cited by examiner, † Cited by third party
Title
AARON M NEWMAN ET AL: "Robust enumeration of cell subsets from tissue expression profiles", HHS PUBLIC ACCESS AUTHOR MANUSCRIPT, vol. 12, no. 5, 30 March 2015 (2015-03-30), GB, pages 453 - 457, XP055323574, ISSN: 1548-7091, DOI: 10.1038/nmeth.3337 *
BRIGNONE ET AL., J. IMMUNOL., vol. 179, 2007, pages 4202 - 4211
BRUCHEZ ET AL., SCIENCE, vol. 281, 1998, pages 2013 - 2016
CHAN ET AL., SCIENCE, vol. 281, 1998, pages 2016 - 2018
FOURCADE ET AL., J. EXP. MED., vol. 207, 2010, pages 2175 - 2186
GEISS ET AL., NATURE BIOTECHNOLOGY, vol. 26, no. 3, 2008, pages 317 - 325
GEISS GARY K ET AL: "Direct multiplexed measurement of gene expression with color-coded probe pairs", NATURE BIOTECHNOLOGY, GALE GROUP INC, US, vol. 26, no. 3, 1 March 2008 (2008-03-01), pages 317 - 325, XP002505107, ISSN: 1087-0156, DOI: 10.1038/NBT1385 *
HEYDUK; HEYDUK, ANALYT. BIOCHEM., vol. 248, 1997, pages 216 - 227
HOHEISEL, NATURE REVIEWS, GENETICS, vol. 7, 2006, pages 200 - 210
J. BIOL. CHEM., vol. 274, 1999, pages 3315 - 3322
KÖLBEL B ET AL: "CD15 focus score for diagnostics of periprosthetic joint infections", ZEITSCHRIFT FÜR RHEUMATOLOGIE, SPRINGER, DE, vol. 74, no. 7, 4 April 2015 (2015-04-04), pages 622 - 630, XP035532513, ISSN: 0340-1855, [retrieved on 20150404], DOI: 10.1007/S00393-015-1571-8 *
LICHTER ET AL., PROC. NATL. ACAD. SCI., vol. 85, 1988, pages 9664 - 9668
LOO ET AL., CLIN. CANCER RES., vol. 15, no. 18, July 2012 (2012-07-01), pages 3834
NICHOLAS P. RESTIFO; MARK E. DUDLEY; STEVEN A. ROSENBERG: "Adoptive immunotherapy for cancer: harnessing the T cell response", NATURE REVIEWS IMMUNOLOGY, vol. 12, April 2012 (2012-04-01), XP055034896, DOI: doi:10.1038/nri3191
PARDOLL, NATURE REVIEWS CANCER, vol. 12, 2012, pages 252 - 264
PINKEL ET AL., PROC. NATL. ACAD. SCI., vol. 85, 1988, pages 9138 - 9142
PIRLKEL ET AL., PROC. NATL. ACAD. SCI., vol. 83, 1986, pages 2934 - 2938
SAKUISHI ET AL., J. EXP. MED., vol. 207, 2010, pages 2187 - 2194
TANNER ET AL., AM..1. PATHOL., vol. 157, 2000, pages 1467 - 1472

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019125184A1 (en) 2017-12-19 2019-06-27 Auckland Uniservices Limited Use of biomarker in cancer therapy

Similar Documents

Publication Publication Date Title
Sinicrope et al. DNA mismatch repair status and colon cancer recurrence and survival in clinical trials of 5-fluorouracil-based adjuvant therapy
Bozionellou et al. Trastuzumab administration can effectively target chemotherapy-resistant cytokeratin-19 messenger RNA–positive tumor cells in the peripheral blood and bone marrow of patients with breast cancer
EP2527460B1 (en) Methods for prediction of clinical outcome to epidermal growth factor receptor inhibitors by cancer patients
Cui et al. Myeloid-derived suppressor cells enhance stemness of cancer cells by inducing microRNA101 and suppressing the corepressor CtBP2
Das et al. Combination therapy with anti–CTLA-4 and anti–PD-1 leads to distinct immunologic changes in vivo
Krieg et al. High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy
EP2318552B1 (en) Methods for stratifying and annotating cancer drug treatment options
Burger et al. Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition
Pansuriya et al. Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome
Perrone et al. PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients
Chevrier et al. An immune atlas of clear cell renal cell carcinoma
Lavin et al. Innate immune landscape in early lung adenocarcinoma by paired single-cell analyses
Plitas et al. Regulatory T cells exhibit distinct features in human breast cancer
Deschoolmeester et al. A review of the most promising biomarkers in colorectal cancer: one step closer to targeted therapy
Roemer et al. PD-L1 and PD-L2 genetic alterations define classical Hodgkin lymphoma and predict outcome
Gu-Trantien et al. CD4+ follicular helper T cell infiltration predicts breast cancer survival
Fujita et al. The clinical relevance of the miR-197/CKS1B/STAT3-mediated PD-L1 network in chemoresistant non-small-cell lung cancer
Fabbri et al. Detection and recovery of circulating colon cancer cells using a dielectrophoresis-based device: KRAS mutation status in pure CTCs
Hartmann et al. Five-gene model to predict survival in mantle-cell lymphoma using frozen or formalin-fixed, paraffin-embedded tissue
Gibney et al. Predictive biomarkers for checkpoint inhibitor-based immunotherapy
Calissano et al. Intraclonal complexity in chronic lymphocytic leukemia: fractions enriched in recently born/divided and older/quiescent cells
Julià et al. An eight-gene blood expression profile predicts the response to infliximab in rheumatoid arthritis
Sia et al. Identification of an immune-specific class of hepatocellular carcinoma, based on molecular features
Artells et al. Tumour CD133 mRNA expression and clinical outcome in surgically resected colorectal cancer patients
JP6247253B2 (en) Leukemia stem cell marker

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 16775196

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase in:

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 16775196

Country of ref document: EP

Kind code of ref document: A1