CN102766210B - 人ctla-4抗体及其应用 - Google Patents
人ctla-4抗体及其应用 Download PDFInfo
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- CN102766210B CN102766210B CN201210037538.0A CN201210037538A CN102766210B CN 102766210 B CN102766210 B CN 102766210B CN 201210037538 A CN201210037538 A CN 201210037538A CN 102766210 B CN102766210 B CN 102766210B
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- A01K2227/105—Murine
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0325—Animal model for autoimmune diseases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Description
小鼠 | 血清IgM(μg/ml) | Ig H链基因型 |
42 | <0.002 | CMD/JHD |
43 | 196 | +/JHD |
44 | <0.002 | CMD/JHD |
45 | 174 | +/JHD |
129×BL6F1 | 153 | +/+ |
JHD | <0.002 | JHD/JHD |
杂交瘤 | ka(1/Ms) | kd(1/s) | Ka(1/M) |
10D1.3 | 4.1×105 | 1.0×10-4 | 4×109 |
4B6.12 | 5.1×105 | 1.3×10-4 | 4×109 |
11E8 | 4.3×105 | 1.8×10-4 | 2×109 |
时间点 | 猴#1 | 猴#2 |
第一次服药前 | 0.0(μg/ml血浆) | 0.0(μg/ml血浆) |
第4天,第二次服药前 | 17.4(μg/ml血浆) | 43.6(μg/ml血浆) |
第7天,第三次服药前 | 83.6(μg/ml血浆) | 97.3(μg/ml血浆) |
第14天 | 90.2(μg/ml血浆) | 70.9(μg/ml血浆) |
Claims (51)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US15045299P | 1999-08-24 | 1999-08-24 | |
US60/150,452 | 1999-08-24 | ||
CN008120374A CN1371416B (zh) | 1999-08-24 | 2000-08-24 | 人ctla-4抗体及其应用 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN008120374A Division CN1371416B (zh) | 1999-08-24 | 2000-08-24 | 人ctla-4抗体及其应用 |
Publications (2)
Publication Number | Publication Date |
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CN102766210A CN102766210A (zh) | 2012-11-07 |
CN102766210B true CN102766210B (zh) | 2015-07-08 |
Family
ID=22534598
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Application Number | Title | Priority Date | Filing Date |
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CN008120374A Expired - Lifetime CN1371416B (zh) | 1999-08-24 | 2000-08-24 | 人ctla-4抗体及其应用 |
CN201210037538.0A Expired - Lifetime CN102766210B (zh) | 1999-08-24 | 2000-08-24 | 人ctla-4抗体及其应用 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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CN008120374A Expired - Lifetime CN1371416B (zh) | 1999-08-24 | 2000-08-24 | 人ctla-4抗体及其应用 |
Country Status (22)
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US (1) | US6984720B1 (zh) |
EP (4) | EP2829609A1 (zh) |
JP (4) | JP4093757B2 (zh) |
KR (3) | KR100942863B1 (zh) |
CN (2) | CN1371416B (zh) |
AT (1) | ATE354655T1 (zh) |
AU (3) | AU784012B2 (zh) |
BE (1) | BE2012C001I2 (zh) |
CA (2) | CA2589418A1 (zh) |
CY (2) | CY1107628T1 (zh) |
DE (2) | DE60033530T2 (zh) |
DK (1) | DK1212422T3 (zh) |
ES (1) | ES2282133T3 (zh) |
FR (1) | FR12C0004I2 (zh) |
HK (1) | HK1048831A1 (zh) |
IL (3) | IL148079A0 (zh) |
LU (1) | LU91928I2 (zh) |
MX (1) | MXPA02001911A (zh) |
NZ (1) | NZ517202A (zh) |
PT (1) | PT1212422E (zh) |
WO (1) | WO2001014424A2 (zh) |
ZA (1) | ZA200201190B (zh) |
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