SG11201900026TA - Antibodies against tim3 and uses thereof - Google Patents

Antibodies against tim3 and uses thereof

Info

Publication number
SG11201900026TA
SG11201900026TA SG11201900026TA SG11201900026TA SG11201900026TA SG 11201900026T A SG11201900026T A SG 11201900026TA SG 11201900026T A SG11201900026T A SG 11201900026TA SG 11201900026T A SG11201900026T A SG 11201900026TA SG 11201900026T A SG11201900026T A SG 11201900026TA
Authority
SG
Singapore
Prior art keywords
california
road
redwood city
antibodies
international
Prior art date
Application number
SG11201900026TA
Inventor
Xiao Min Schebye
Mark J Selby
Michelle Minhua Han
Christine BEE
Andy X Deng
Anan Chuntharapai
Brigitte Devaux
Huiming Li
Paul O Sheppard
Alan J Korman
Daniel F Ardourel
Ekaterina DEYANOVA
Richard Huang
Guodong Chen
Michelle Kuhne
Hong-An Truong
Original Assignee
Squibb Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201662362541P priority Critical
Priority to US201762459499P priority
Application filed by Squibb Bristol Myers Co filed Critical Squibb Bristol Myers Co
Priority to PCT/US2017/041946 priority patent/WO2018013818A2/en
Publication of SG11201900026TA publication Critical patent/SG11201900026TA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046Stomach, Intestines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71Decreased effector function due to an Fc-modification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74Inducing cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD 1101111 0 DOI HIM 011101 0 0111111 01110111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2018/013818 A2 18 January 2018 (18.01.2018) W I P0 I P C T (51) International Patent Classification: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, C07K 16/28 (2006.01) HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (21) International Application Number: KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, PCT/US2017/041946 MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (22) International Filing Date: SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, 13 July 2017 (13.07.2017) TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (25) Filing Language: English (84) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (30) Priority Data: UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 62/362,541 14 July 2016 (14.07.2016) US TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 62/459,499 15 February 2017 (15.02.2017) US EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (71) Applicant: BRISTOL-MYERS SQUIBB COMPANY MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, [US/US]; Rt. 206 & Province Line Road, Princeton, New KM, ML, MR, NE, SN, TD, TG). Jersey 08543 (US). (72) Inventors: SCHEBYE, Xiao Min; 700 Bay Road, Red- Declarations under Rule 4.17: wood City, California 94063 (US). SELBY, Mark J.; — of inventorship (Rule 4.17(iv)) — 700 Bay Road, Redwood City, California 94063 (US). Published: HAN, Michelle Minhua; 700 Bay Road, Redwood City, — without international search report and to be republished = California 94063 (US). BEE, Christine; 700 Bay Road, upon receipt of that report (Rule 48.2(g)) Redwood City, California 94063 (US). DENG, Andy X .; _ with sequence listing part of description (Rule 5.2(a)) 700 Bay Road, Redwood City, California 94063 (US). _ CHUNTHARAPAI, Anan; 700 Bay Road, Redwood City, California 94063 (US). DEVAUX, Brigitte; 320 Duluth = Circle, Palo Alto, California 94306 (US). LI, Huiming; 91 Grove Street, Lexington, Massachusetts 02420 (US). —_ SHEPPARD, Paul 0.; 13532 278th Drive NE, Granite = Falls, Washington 98252 (US). KORMAN, Alan J.; 700 Bay Road, Redwood City, California 94063 (US). AR- = - DOUREL, Daniel F.; 19010 201st Avenue NE, Wood- inville, Washington 98077 (US). DEYANOVA, Ekateri- - na; Rt. 206 & Province Line Road, Princeton, New Jer- _ = sey 08543 (US). HUANG, Richard; Rt. 206 & Province Line Road, Princeton, New Jersey 08543 (US). CHEN, Guodong; Rt. 206 & Province Line Road, Princeton, New = Jersey 08543 (US). KUHNE, Michelle; 700 Bay Road, Redwood City, California 94063 (US). TRUONG, Hong- = An; 700 Bay Road, Redwood City, California 94063 (US). = Agent: KIM, Ji-Eun et al.; Sterne, Kessler, Goldstein & (74) = — Fox P.L.L.C., 1100 New York Avenue, NW, Washington, = District of Columbia 20005 (US). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (81) — N GC Il X ) (54) Title: ANTIBODIES AGAINST TIM3 AND USES THEREOF en 1-1 (57) : Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin- 0 ----. domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic GC Il applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, © polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors com- el prising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof. O
SG11201900026TA 2016-07-14 2017-07-13 Antibodies against tim3 and uses thereof SG11201900026TA (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US201662362541P true 2016-07-14 2016-07-14
US201762459499P true 2017-02-15 2017-02-15
PCT/US2017/041946 WO2018013818A2 (en) 2016-07-14 2017-07-13 Antibodies against tim3 and uses thereof

Publications (1)

Publication Number Publication Date
SG11201900026TA true SG11201900026TA (en) 2019-01-30

Family

ID=59383664

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201900026TA SG11201900026TA (en) 2016-07-14 2017-07-13 Antibodies against tim3 and uses thereof

Country Status (13)

Country Link
US (2) US10077306B2 (en)
EP (1) EP3484920A2 (en)
KR (1) KR20190027384A (en)
CN (1) CN109757103A (en)
AU (1) AU2017297506A1 (en)
CA (1) CA3030765A1 (en)
CL (1) CL2019000100A1 (en)
CO (1) CO2019000372A2 (en)
IL (1) IL264011D0 (en)
SG (1) SG11201900026TA (en)
TW (1) TW201811829A (en)
UY (1) UY37325A (en)
WO (1) WO2018013818A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201900026TA (en) 2016-07-14 2019-01-30 Squibb Bristol Myers Co Antibodies against tim3 and uses thereof
WO2018183928A1 (en) 2017-03-31 2018-10-04 Bristol-Myers Squibb Company Methods of treating tumor
WO2018218056A1 (en) 2017-05-25 2018-11-29 Birstol-Myers Squibb Company Antibodies comprising modified heavy constant regions
WO2019075468A1 (en) 2017-10-15 2019-04-18 Bristol-Myers Squibb Company Methods of treating tumor

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