SG11202104373YA - Anti-ctla4 antibodies, antibody fragments, their immunoconjugates and uses thereof - Google Patents

Anti-ctla4 antibodies, antibody fragments, their immunoconjugates and uses thereof

Info

Publication number
SG11202104373YA
SG11202104373YA SG11202104373YA SG11202104373YA SG11202104373YA SG 11202104373Y A SG11202104373Y A SG 11202104373YA SG 11202104373Y A SG11202104373Y A SG 11202104373YA SG 11202104373Y A SG11202104373Y A SG 11202104373YA SG 11202104373Y A SG11202104373Y A SG 11202104373YA
Authority
SG
Singapore
Prior art keywords
immunoconjugates
antibody fragments
ctla4 antibodies
ctla4
antibodies
Prior art date
Application number
SG11202104373YA
Inventor
Jay Short
Gerhard Frey
Hwai Wen Chang
Original Assignee
Bioatla Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioatla Inc filed Critical Bioatla Inc
Publication of SG11202104373YA publication Critical patent/SG11202104373YA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70521—CD28, CD152
SG11202104373YA 2018-10-31 2019-10-25 Anti-ctla4 antibodies, antibody fragments, their immunoconjugates and uses thereof SG11202104373YA (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862753498P 2018-10-31 2018-10-31
US201962798234P 2019-01-29 2019-01-29
US201962803060P 2019-02-08 2019-02-08
US201962822971P 2019-03-24 2019-03-24
US201962824014P 2019-03-26 2019-03-26
US201962823992P 2019-03-26 2019-03-26
PCT/US2019/058066 WO2020092155A1 (en) 2018-10-31 2019-10-25 Anti-ctla4 antibodies, antibody fragments, their immunoconjugates and uses thereof

Publications (1)

Publication Number Publication Date
SG11202104373YA true SG11202104373YA (en) 2021-05-28

Family

ID=70463883

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202104373YA SG11202104373YA (en) 2018-10-31 2019-10-25 Anti-ctla4 antibodies, antibody fragments, their immunoconjugates and uses thereof

Country Status (14)

Country Link
US (1) US20230192858A1 (en)
EP (1) EP3873940A4 (en)
JP (1) JP7445995B2 (en)
KR (2) KR102521276B1 (en)
CN (1) CN112996813A (en)
AU (2) AU2019371223B2 (en)
BR (1) BR112021008060A2 (en)
CA (1) CA3117700C (en)
IL (2) IL282610B (en)
MX (1) MX2021005048A (en)
NZ (1) NZ775959A (en)
SG (1) SG11202104373YA (en)
TW (1) TW202028249A (en)
WO (1) WO2020092155A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113924118A (en) * 2019-04-18 2022-01-11 百时美施贵宝公司 Ipimumab variants with enhanced binding specificity at low pH
JP2023537412A (en) 2020-08-13 2023-08-31 ブリストル－マイヤーズ スクイブ カンパニー Methods of Redirecting IL-2 to Target Cells of Interest
EP4240769A1 (en) * 2020-11-06 2023-09-13 Bristol-Myers Squibb Company Dosing and administration of non-fucosylated anti-ctla-4 antibody as monotherapy
US20220306743A1 (en) * 2021-03-01 2022-09-29 Xilio Development, Inc. Combination of ctla4 and pd1/pdl1 antibodies for treating cancer
WO2023154799A1 (en) 2022-02-14 2023-08-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Combination immunotherapy for treating cancer
WO2024056049A1 (en) * 2022-09-16 2024-03-21 同润生物医药(上海)有限公司 Ph-dependent anti-ctla4 antibody or antigen-binding fragment

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100942863B1 (en) * 1999-08-24 2010-02-17 메다렉스, 인코포레이티드 Human ctla-4 antibodies and their uses
US6981720B2 (en) * 2003-11-07 2006-01-03 Agilent Technologies, Inc. Tapered ceramic GC fitting and assembly
EP2007423A2 (en) 2006-04-05 2008-12-31 Pfizer Products Incorporated Ctla4 antibody combination therapy
KR101837329B1 (en) * 2008-04-25 2018-03-09 다이액스 코포레이션 Antibodies against fcrn and use thereof
CN103201293B (en) 2010-09-08 2016-04-27 哈洛齐梅公司 The method of assessment and qualification or development condition active therapeutic protein
GB201103955D0 (en) * 2011-03-09 2011-04-20 Antitope Ltd Antibodies
RU2014147741A (en) * 2012-04-27 2016-06-20 Байоатла Ллк. MODIFIED AREAS OF ANTIBODIES AND THEIR APPLICATION
CA2881679C (en) * 2012-08-13 2021-01-26 Regeneron Pharmaceuticals, Inc. Anti-pcsk9 antibodies with ph-dependent binding characteristics
US9968674B2 (en) 2013-10-18 2018-05-15 Regeneron Pharmaceuticals, Inc. Methods and compositions comprising a combination of a VEGF Trap and an anti-CTLA-4 antibody
CN104292334B (en) * 2014-04-25 2018-11-27 河南省健康伟业生物医药研究股份有限公司 A kind of anti-CTLA-4 monoclonal antibody of full source of people, preparation method and application
EP3189152A4 (en) 2014-09-03 2018-04-04 BioAtla LLC Discovering and producing conditionally active biologic proteins in the same eukaryotic cell production hosts
WO2016130986A1 (en) * 2015-02-13 2016-08-18 Sorrento Therapeutics, Inc. Antibody therapeutics that bind ctla4
PL3303394T3 (en) * 2015-05-29 2020-11-16 Agenus Inc. Anti-ctla-4 antibodies and methods of use thereof
WO2017218707A2 (en) * 2016-06-14 2017-12-21 Xencor, Inc. Bispecific checkpoint inhibitor antibodies
JP7080219B2 (en) * 2016-08-30 2022-06-03 ゼンコア インコーポレイテッド Bispecific immunomodulatory antibodies that link to co-stimulatory and checkpoint receptors
WO2018218076A1 (en) * 2017-05-26 2018-11-29 Janux Therapeutics, Inc. Modified antibodies
CN111699195A (en) * 2018-02-02 2020-09-22 肿瘤免疫股份有限公司 Mutant anti-CTLA-4 antibodies with improved immunotherapeutic effect but reduced adverse effects

Also Published As

Publication number Publication date
CN112996813A (en) 2021-06-18
BR112021008060A2 (en) 2021-11-23
AU2019371223A1 (en) 2021-06-03
IL282610A (en) 2021-06-30
KR20230051630A (en) 2023-04-18
US20230192858A1 (en) 2023-06-22
WO2020092155A1 (en) 2020-05-07
AU2022204161A1 (en) 2022-06-30
IL291545A (en) 2022-05-01
KR102521276B1 (en) 2023-04-12
KR20210071058A (en) 2021-06-15
CA3117700A1 (en) 2020-05-07
EP3873940A1 (en) 2021-09-08
CA3117700C (en) 2024-02-20
JP2022513384A (en) 2022-02-07
IL282610B (en) 2022-05-01
AU2019371223B2 (en) 2022-03-17
JP7445995B2 (en) 2024-03-08
MX2021005048A (en) 2021-09-08
EP3873940A4 (en) 2022-11-30
NZ775959A (en) 2022-08-26
TW202028249A (en) 2020-08-01

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