BR112018074192A8 - Método para tratamento de um sujeito, método para produzir uma composição celular, composição de células, composição de vacina e kit - Google Patents

Método para tratamento de um sujeito, método para produzir uma composição celular, composição de células, composição de vacina e kit

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Publication number
BR112018074192A8
BR112018074192A8 BR112018074192A BR112018074192A BR112018074192A8 BR 112018074192 A8 BR112018074192 A8 BR 112018074192A8 BR 112018074192 A BR112018074192 A BR 112018074192A BR 112018074192 A BR112018074192 A BR 112018074192A BR 112018074192 A8 BR112018074192 A8 BR 112018074192A8
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BR
Brazil
Prior art keywords
subject
composition
cell composition
inventors
valproic acid
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BR112018074192A
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English (en)
Other versions
BR112018074192A2 (pt
Inventor
Griscelli Frank
Turhan Ali
Bennaceur-Griscelli Annelise
Original Assignee
Inst Nat Sante Rech Med
Univ Paris Sud
Univ Paris Descartes
Assist Publique Hopitaux Paris Aphp
Univ Paris
Univ Paris Cite
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Application filed by Inst Nat Sante Rech Med, Univ Paris Sud, Univ Paris Descartes, Assist Publique Hopitaux Paris Aphp, Univ Paris, Univ Paris Cite filed Critical Inst Nat Sante Rech Med
Publication of BR112018074192A2 publication Critical patent/BR112018074192A2/pt
Publication of BR112018074192A8 publication Critical patent/BR112018074192A8/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/0011—Cancer antigens
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
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    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
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    • A61P35/04—Antineoplastic agents specific for metastasis
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    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract

Os inventores desenvolveram um modelo de tumor mamário 4T1 metastático em camundongos BALB/c. Eles mostraram que a vacinação com células-tronco embrionárias xenogênicas em combinação com ácido valpróico (VPA) gera uma maior resposta anti-tumoral contra o câncer de mama e inibe o desenvolvimento de metástases. Eles estabeleceram que essas respostas são alcançadas apenas pela adição de ácido valpróico no regime terapêutico em comparação com o uso de ESCs ou iPSCs isoladamente. Assim, os inventores proveram uma nova estratégia terapêutica para tratar cânceres que expressam antígenos embrionários. Assim, a presente invenção diz respeito a i) uma população de células pluripotentes e ii) um composto selecionado a partir de um grupo que ativa a expressão de MHC, como uma preparação combinada para uso em um método para tratamento de um sujeito que sofre de um câncer, compreendendo uma etapa de administração simultaneamente, separadamente ou sequencialmente ao referido sujeito de uma quantidade terapeuticamente eficaz do mesmo.
BR112018074192A 2016-05-25 2017-05-24 Método para tratamento de um sujeito, método para produzir uma composição celular, composição de células, composição de vacina e kit BR112018074192A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16305607 2016-05-25
PCT/EP2017/062604 WO2017202949A1 (en) 2016-05-25 2017-05-24 Methods and compositions for treating cancers

Publications (2)

Publication Number Publication Date
BR112018074192A2 BR112018074192A2 (pt) 2019-08-13
BR112018074192A8 true BR112018074192A8 (pt) 2022-11-22

Family

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BR112018074192A BR112018074192A8 (pt) 2016-05-25 2017-05-24 Método para tratamento de um sujeito, método para produzir uma composição celular, composição de células, composição de vacina e kit

Country Status (11)

Country Link
US (2) US11458194B2 (pt)
EP (1) EP3463433A1 (pt)
JP (2) JP2019516754A (pt)
KR (1) KR20190032295A (pt)
CN (2) CN109689089A (pt)
AU (2) AU2017270234B2 (pt)
BR (1) BR112018074192A8 (pt)
CA (1) CA3025057A1 (pt)
IL (2) IL305882A (pt)
RU (1) RU2741786C2 (pt)
WO (1) WO2017202949A1 (pt)

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