EP0754225A4 - Transgenic non-human animals capable of producing heterologous antibodies - Google Patents

Transgenic non-human animals capable of producing heterologous antibodies

Info

Publication number
EP0754225A4
EP0754225A4 EP94916581A EP94916581A EP0754225A4 EP 0754225 A4 EP0754225 A4 EP 0754225A4 EP 94916581 A EP94916581 A EP 94916581A EP 94916581 A EP94916581 A EP 94916581A EP 0754225 A4 EP0754225 A4 EP 0754225A4
Authority
EP
European Patent Office
Prior art keywords
transgenic non
human animals
animals capable
heterologous antibodies
producing heterologous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94916581A
Other languages
German (de)
French (fr)
Other versions
EP0754225A1 (en
Inventor
Nils Lonberg
Robert M Kay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genpharm International Inc
Original Assignee
Genpharm International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/053,131 external-priority patent/US5661016A/en
Priority claimed from US08/096,762 external-priority patent/US5814318A/en
Application filed by Genpharm International Inc filed Critical Genpharm International Inc
Publication of EP0754225A1 publication Critical patent/EP0754225A1/en
Publication of EP0754225A4 publication Critical patent/EP0754225A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/30—Animal model comprising expression system for selective cell killing, e.g. toxins, enzyme dependent prodrug therapy using ganciclovir
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention relates to transgenic non-human animals capable of producing heterologous antibodies and methods for producing human sequence antibodies which bind to human antigens with substantial affinity.
EP94916581A 1993-04-26 1994-04-25 Transgenic non-human animals capable of producing heterologous antibodies Withdrawn EP0754225A4 (en)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US53131 1993-04-26
US08/053,131 US5661016A (en) 1990-08-29 1993-04-26 Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US96762 1993-07-22
US08/096,762 US5814318A (en) 1990-08-29 1993-07-22 Transgenic non-human animals for producing heterologous antibodies
US15530193A 1993-11-18 1993-11-18
US155301 1993-11-18
US16173993A 1993-12-03 1993-12-03
US16569993A 1993-12-10 1993-12-10
US165699 1993-12-10
US161739 1993-12-10
US20974194A 1994-03-09 1994-03-09
US209741 1994-03-09
PCT/US1994/004580 WO1994025585A1 (en) 1993-04-26 1994-04-25 Transgenic non-human animals capable of producing heterologous antibodies

Publications (2)

Publication Number Publication Date
EP0754225A1 EP0754225A1 (en) 1997-01-22
EP0754225A4 true EP0754225A4 (en) 2001-01-31

Family

ID=27556670

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94916581A Withdrawn EP0754225A4 (en) 1993-04-26 1994-04-25 Transgenic non-human animals capable of producing heterologous antibodies

Country Status (5)

Country Link
EP (1) EP0754225A4 (en)
JP (3) JPH08509612A (en)
AU (1) AU6819494A (en)
CA (1) CA2161351C (en)
WO (1) WO1994025585A1 (en)

Families Citing this family (724)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6713610B1 (en) 1990-01-12 2004-03-30 Raju Kucherlapati Human antibodies derived from immunized xenomice
US7041871B1 (en) 1995-10-10 2006-05-09 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US7084260B1 (en) 1996-10-10 2006-08-01 Genpharm International, Inc. High affinity human antibodies and human antibodies against human antigens
US5770429A (en) * 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US6300129B1 (en) * 1990-08-29 2001-10-09 Genpharm International Transgenic non-human animals for producing heterologous antibodies
AU2008202860B9 (en) * 1995-04-27 2012-03-29 Amgen Fremont Inc. Human Antibodies Derived From Immunized Xenomice
EP1978033A3 (en) * 1995-04-27 2008-12-24 Amgen Fremont Inc. Human antibodies derived from immunized xenomice
AU4376400A (en) * 1995-04-27 2000-11-30 Abgenix, Inc. Human antibodies derived from immunized xenomice
CA2219486A1 (en) * 1995-04-28 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
ATE274594T1 (en) * 1995-06-07 2004-09-15 Jacob N Wohlstadter METHOD OF INCREASE ENZYM DIVERSITY
US5919681A (en) * 1995-06-07 1999-07-06 Wohlstadter Jacob N Method for promoting enzyme diversity
US5914256A (en) * 1995-06-07 1999-06-22 Wohlstadter Jacob N Method for promoting enzyme diversity
JPH11510047A (en) * 1995-07-21 1999-09-07 ユニバーシティ・オブ・ネブラスカ・ボード・オブ・リージェンツ Compositions and methods for catalyzing the hydrolysis of HIV gp120
US6537776B1 (en) 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
EP0966971A1 (en) 1996-04-23 1999-12-29 Chugai Seiyaku Kabushiki Kaisha Cerebral stroke/cerebral edema preventive or remedy containing il-8 binding inhibitor as active ingredient
JP2000510692A (en) 1996-05-04 2000-08-22 ゼネカ リミテッド Monoclonal antibodies to CEA, conjugates comprising the antibodies, and their therapeutic use in ADEPT systems
CA2616914C (en) 1996-12-03 2012-05-29 Abgenix, Inc. Egfr-binding antibody
AU2008200005B2 (en) * 1996-12-03 2012-05-17 Amgen Fremont Inc. Transgenic Mammals Having Human Ig Loci Including Plural Vh and Vk Regions and Antibodies Produced Therefrom
US6080910A (en) * 1997-02-20 2000-06-27 Case Western Reserve University Transgenic knockout animals lacking IgG3
ES2312184T3 (en) 1997-03-21 2009-02-16 Chugai Seiyaku Kabushiki Kaisha THERAPEUTIC PREVENTIVE AGENTS FOR THE TREATMENT OF MULTIPLE SCLEROSIS, CONTAINING ANTI-RECEIVING ANTIBODIES OF IL-6 ANTAGONISTS.
US8173127B2 (en) 1997-04-09 2012-05-08 Intellect Neurosciences, Inc. Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof
US20020173629A1 (en) 1997-05-05 2002-11-21 Aya Jakobovits Human monoclonal antibodies to epidermal growth factor receptor
US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
GB9711167D0 (en) * 1997-05-31 1997-07-23 Babraham The Inst Telomere-associated chromosome fragmentation
WO1999008707A1 (en) 1997-08-15 1999-02-25 Chugai Seiyaku Kabushiki Kaisha Preventives and/or remedies for systemic lupus erythematosus containing anti-il-6 receptor antibody as the active ingredient
GB9823930D0 (en) * 1998-11-03 1998-12-30 Babraham Inst Murine expression of human ig\ locus
WO2000026352A1 (en) 1998-11-04 2000-05-11 Chugai Research Institute For Molecular Medicine, Inc. Novel trypsin family serine proteases
US7109003B2 (en) 1998-12-23 2006-09-19 Abgenix, Inc. Methods for expressing and recovering human monoclonal antibodies to CTLA-4
EE05627B1 (en) 1998-12-23 2013-02-15 Pfizer Inc. Human monoclonal antibodies to CTLA-4
CZ302706B6 (en) 1998-12-23 2011-09-14 Pfizer Inc. Human monoclonal antibody, pharmaceutical composition containing thereof, cell line producing the antibody, isolated molecule encoding heavy or light chain of said antibody, host cell containing said isolated molecule and use of said antibody
US6914128B1 (en) 1999-03-25 2005-07-05 Abbott Gmbh & Co. Kg Human antibodies that bind human IL-12 and methods for producing
EP1961818A3 (en) 1999-04-09 2008-09-10 Chugai Seiyaku Kabushiki Kaisha Novel fetal genes
EP1188830B1 (en) 1999-06-02 2010-01-20 Chugai Seiyaku Kabushiki Kaisha Novel hemopoietin receptor protein ,nr10
US6833268B1 (en) 1999-06-10 2004-12-21 Abgenix, Inc. Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions
ES2307526T3 (en) 1999-08-23 2008-12-01 Chugai Seiyaku Kabushiki Kaisha POTENTIALS OF THE EXPRESSION OF THE ANTIGEN HM1.24.
MXPA02001911A (en) 1999-08-24 2003-07-21 Medarex Inc Human ctla 4 antibodies and their uses.
US7605238B2 (en) 1999-08-24 2009-10-20 Medarex, Inc. Human CTLA-4 antibodies and their uses
AU6871900A (en) 1999-09-06 2001-04-10 Chugai Seiyaku Kabushiki Kaisha Tsg-like gene
AU7491800A (en) * 1999-09-15 2001-04-17 Therapeutic Human Polyclonals, Inc. Immunotherapy with substantially human polyclonal antibody preparations purifiedfrom genetically engineered birds
EP1486510B1 (en) 1999-09-21 2009-05-13 Chugai Seiyaku Kabushiki Kaisha Use of transporter gene oatp-c to screen for test compounds
US8062638B1 (en) 1999-10-01 2011-11-22 Chugai Seiyaku Kabushiki Kaisha Prevention and treatment of diseases associated with blood coagulation
CN100497624C (en) 2000-01-24 2009-06-10 杉山治夫 WT1-interacting protein WTIP
WO2001082968A1 (en) 2000-04-28 2001-11-08 Chugai Seiyaku Kabushiki Kaisha Cell proliferation inhibitors
US7560534B2 (en) 2000-05-08 2009-07-14 Celldex Research Corporation Molecular conjugates comprising human monoclonal antibodies to dendritic cells
JP3597140B2 (en) 2000-05-18 2004-12-02 日本たばこ産業株式会社 Human monoclonal antibody against costimulatory molecule AILIM and pharmaceutical use thereof
US6902734B2 (en) 2000-08-07 2005-06-07 Centocor, Inc. Anti-IL-12 antibodies and compositions thereof
UA81743C2 (en) 2000-08-07 2008-02-11 Центокор, Инк. HUMAN MONOCLONAL ANTIBODY WHICH SPECIFICALLY BINDS TUMOR NECROSIS FACTOR ALFA (TNFα), PHARMACEUTICAL MIXTURE CONTAINING THEREOF, AND METHOD FOR TREATING ARTHRITIS
US7288390B2 (en) 2000-08-07 2007-10-30 Centocor, Inc. Anti-dual integrin antibodies, compositions, methods and uses
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US6586251B2 (en) * 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US20050144655A1 (en) 2000-10-31 2005-06-30 Economides Aris N. Methods of modifying eukaryotic cells
DZ3494A1 (en) 2001-01-05 2002-07-11 Pfizer INSULIN ANALOGUE GROWTH FACTOR ANTI-RECEPTOR ANTIBODIES
JP3986439B2 (en) 2001-02-07 2007-10-03 中外製薬株式会社 Hematopoietic tumor therapeutic agent
JP2005507635A (en) 2001-02-12 2005-03-24 メダレックス， インク． Human monoclonal antibody against Fcα receptor (CD89)
UA80091C2 (en) 2001-04-02 2007-08-27 Chugai Pharmaceutical Co Ltd Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist
IL161968A0 (en) 2001-11-14 2005-11-20 Centocor Inc Anti-il-6 antibodies, compositions, methods and uses
US7435871B2 (en) 2001-11-30 2008-10-14 Amgen Fremont Inc. Transgenic animals bearing human Igλ light chain genes
JP4063769B2 (en) 2001-12-28 2008-03-19 中外製薬株式会社 Protein stabilization method
CN1638800A (en) 2002-01-09 2005-07-13 米德列斯公司 Human monoclonal antibodies against CD30
EP3192528A1 (en) 2002-02-14 2017-07-19 Chugai Seiyaku Kabushiki Kaisha Formulation of anti-il6r antibody-containing solutions comprising a sugar as a stabilizer
ATE431406T1 (en) 2002-02-25 2009-05-15 Genentech Inc NEW TYPE 1 CYTOKINE RECEPTOR GLM-R
AU2003220930A1 (en) 2002-03-29 2003-10-13 Chugai Seiyaku Kabushiki Kaisha Emthod of screening transporter inhibitor
WO2004022597A1 (en) 2002-09-04 2004-03-18 Chugai Seiyaku Kabushiki Kaisha Antibody against blood-solubilized n-terminal peptide in gpc3
JP2005529873A (en) 2002-04-12 2005-10-06 メダレックス インコーポレイテッド Method of treatment using CTLA-4 antibody
US7217796B2 (en) 2002-05-24 2007-05-15 Schering Corporation Neutralizing human anti-IGFR antibody
EP1513934B1 (en) 2002-06-06 2011-03-02 Oncotherapy Science, Inc. Genes and polypeptides relating to human colon cancers
ES2361541T3 (en) 2002-06-06 2011-06-17 Oncotherapy Science, Inc. GENES AND POLYPEPTIDES RELATED TO HUMAN COLON CANCER.
JP4489591B2 (en) 2002-08-27 2010-06-23 中外製薬株式会社 Method for stabilizing protein solution formulations
AU2003262087B2 (en) 2002-09-11 2010-11-11 Chugai Seiyaku Kabushiki Kaisha Protein purification method
TW200413539A (en) 2002-09-30 2004-08-01 Oncotherapy Science Inc Genes and polypeptides relating to prostate cancers
TW200413725A (en) 2002-09-30 2004-08-01 Oncotherapy Science Inc Method for diagnosing non-small cell lung cancers
WO2004035607A2 (en) 2002-10-17 2004-04-29 Genmab A/S Human monoclonal antibodies against cd20
AU2003301576A1 (en) 2002-10-22 2004-05-13 Eisai Co., Ltd. Gene expressed specifically in dopamine-producing neuron precursor cells after termination of division
AU2003280643A1 (en) 2002-10-30 2004-05-25 Chugai Seiyaku Kabushiki Kaisha Membrane protein originating in mast cells
KR101329843B1 (en) 2002-11-15 2013-11-14 젠맵 에이/에스 Human monoclonal antibodies against cd25
ES2347239T3 (en) 2002-12-02 2010-10-27 Amgen Fremont Inc. ANTIBODIES DIRECTED TO THE TUMOR NECROSIS FACTOR AND USES OF THE SAME.
ATE527278T1 (en) 2002-12-16 2011-10-15 Genmab As HUMAN MONOCLONAL ANTIBODIES AGAINST INTERLEUKIN 8 (IL-8)
EP1613750B1 (en) 2003-03-19 2015-10-14 Amgen Fremont Inc. Antibodies against t cell immunoglobulin domain and mucin domain 1 (tim-1) antigen and uses thereof
GB2401040A (en) 2003-04-28 2004-11-03 Chugai Pharmaceutical Co Ltd Method for treating interleukin-6 related diseases
US7491802B2 (en) 2003-05-28 2009-02-17 Takeda Pharmaceutical Company Limited Anti-BAMBI antibody and diagnostic or remedy for colon cancer and liver cancer
US9708410B2 (en) 2003-05-30 2017-07-18 Janssen Biotech, Inc. Anti-tissue factor antibodies and compositions
WO2005004794A2 (en) 2003-06-09 2005-01-20 Alnylam Pharmaceuticals Inc. Method of treating neurodegenerative disease
WO2005017155A1 (en) 2003-06-18 2005-02-24 Chugai Seiyaku Kabushiki Kaisha Fucose transporter
AU2004259398A1 (en) 2003-06-27 2005-02-03 Amgen Fremont Inc. Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof
US7396914B2 (en) 2003-08-04 2008-07-08 University Of Massachusetts SARS nucleic acids, proteins, antibodies, and uses thereof
EP1652923B1 (en) 2003-08-08 2011-10-12 Perseus Proteomics Inc. Gene overexpressed in cancer
JP2007521232A (en) 2003-08-08 2007-08-02 アブジェニックス・インコーポレーテッド Antibodies against parathyroid hormone (PTH) and uses thereof
AU2003271174A1 (en) 2003-10-10 2005-04-27 Chugai Seiyaku Kabushiki Kaisha Double specific antibodies substituting for functional protein
JPWO2005035754A1 (en) 2003-10-14 2006-12-21 中外製薬株式会社 Bispecific antibodies that replace functional proteins
US7642341B2 (en) 2003-12-18 2010-01-05 Merck Serono S.A. Angiogenesis inhibiting molecules, their selection, production and their use in the treatment of cancer
EP1533617A1 (en) 2003-11-19 2005-05-25 RMF Dictagene S.A. Angiogenesis inhibiting molecules, their selection, production and their use in the treatment and diagnosis of cancer
CA2548185A1 (en) 2003-12-03 2005-06-16 Chugai Seiyaku Kabushiki Kaisha Expression systems using mammalian .beta.-actin promoter
KR101374514B1 (en) 2003-12-10 2014-03-13 메다렉스, 인코포레이티드 Ip-10 antibodies and their uses
DK2418220T3 (en) 2003-12-10 2017-11-06 Squibb & Sons Llc INTERFERON-ALPHA ANTIBODIES AND APPLICATIONS THEREOF
EP1710255A4 (en) 2003-12-12 2008-09-24 Chugai Pharmaceutical Co Ltd Modified antibodies recognising receptor trimers or higher multimers
CA2553946C (en) 2004-02-06 2019-02-26 University Of Massachusetts Antibodies against clostridium difficile toxins and uses thereof
US7625549B2 (en) 2004-03-19 2009-12-01 Amgen Fremont Inc. Determining the risk of human anti-human antibodies in transgenic mice
MXPA06010673A (en) 2004-03-19 2007-06-20 Amgen Inc Reducing the risk of human and anti-human antibodies through v gene manipulation.
JP4938451B2 (en) 2004-03-23 2012-05-23 オンコセラピー・サイエンス株式会社 Methods for diagnosis of non-small cell lung cancer
PL1737891T3 (en) 2004-04-13 2013-08-30 Hoffmann La Roche Anti-p-selectin antibodies
WO2005103081A2 (en) 2004-04-20 2005-11-03 Genmab A/S Human monoclonal antibodies against cd20
US9228008B2 (en) 2004-05-28 2016-01-05 Idexx Laboratories, Inc. Canine anti-CD20 antibodies
EA012622B1 (en) 2004-06-01 2009-10-30 Домэнтис Лимитед Bispecific fusion antibodies with enhanced serum half-life
LT2662390T (en) 2004-06-21 2017-10-10 E. R. Squibb & Sons, L.L.C. Interferon alpha receptor 1 antibodies and their uses
JP5112863B2 (en) 2004-07-01 2013-01-09 ノヴォ ノルディスク アー／エス Human anti-KIR antibody
MY145073A (en) 2004-07-09 2011-12-15 Chugai Pharmaceutical Co Ltd Anti-glypican 3 antibody
US20080199437A1 (en) 2004-07-22 2008-08-21 Eisai Co., Ltd. Lrp4/Corin Dopaminergic Neuron Progenitor Cell Markers
TWI309240B (en) 2004-09-17 2009-05-01 Hoffmann La Roche Anti-ox40l antibodies
MX2007003533A (en) 2004-10-01 2007-05-23 Medarex Inc Methods of treating cd30 positive lymphomas.
US20080026457A1 (en) 2004-10-22 2008-01-31 Kevin Wells Ungulates with genetically modified immune systems
CA3079874C (en) 2004-10-22 2023-01-03 Revivicor, Inc. Ungulates with genetically modified immune systems
CA2587903A1 (en) 2004-11-17 2006-05-26 Amgen Fremont Inc. Fully human monoclonal antibodies to il-13
NZ555464A (en) 2004-12-02 2010-03-26 Domantis Ltd Bispecific domain antibodies targeting serum albumin and glp-1 or pyy
EP1838737B1 (en) 2004-12-20 2011-04-06 Amgen Fremont Inc. Binding proteins specific for human matriptase
WO2006068953A2 (en) 2004-12-21 2006-06-29 Astrazeneca Ab Antibodies directed to angiopoietin-2 and uses thereof
US20090061485A1 (en) 2004-12-22 2009-03-05 Chugai Seiyaku Kabushiki Kaisha Method of Producing an Antibody Using a Cell in Which the Function of Fucose Transporter Is Inhibited
ES2395953T3 (en) 2005-01-26 2013-02-18 Amgen Fremont Inc. Antibodies to interleukin-1 beta
EP1856278A2 (en) 2005-02-10 2007-11-21 Oncotherapy Science, Inc. Method of diagnosing bladder cancer
JP2008530244A (en) 2005-02-18 2008-08-07 メダレックス， インク． Monoclonal antibody against CD30 lacking fucosyl residues
TWI406870B (en) 2005-02-21 2013-09-01 Chugai Pharmaceutical Co Ltd A method of making a protein using hamster IGF-1
WO2006098464A1 (en) 2005-03-14 2006-09-21 Link Genomics, Inc. Method for diagnosis of prostate cancer
ES2716874T3 (en) 2005-03-23 2019-06-17 Genmab As Antibodies against cd38 for the treatment of multiple myeloma
SI1876236T1 (en) 2005-04-08 2014-11-28 Chugai Seiyaku Kabushiki Kaisha Antibody substituting for function of blood coagulation factor viii
PA8672101A1 (en) 2005-04-29 2006-12-07 Centocor Inc ANTI-IL-6 ANTIBODIES, COMPOSITIONS, METHODS AND USES
EP3530736A3 (en) 2005-05-09 2019-11-06 ONO Pharmaceutical Co., Ltd. Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics
AU2006256041B2 (en) 2005-06-10 2012-03-29 Chugai Seiyaku Kabushiki Kaisha Stabilizer for protein preparation comprising meglumine and use thereof
EP3501537A1 (en) 2005-06-30 2019-06-26 Janssen Biotech, Inc. Anti-il23 antibodies, compositions, methods and uses
SI1907424T1 (en) 2005-07-01 2015-12-31 E. R. Squibb & Sons, L.L.C. Human monoclonal antibodies to programmed death ligand 1 (pd-l1)
EP1907859B1 (en) 2005-07-27 2011-03-02 Oncotherapy Science, Inc. Genes and polypeptides relating to prostate cancers
JP5230420B2 (en) 2005-08-18 2013-07-10 ゲンマブ エー／エス Treatment with CD4 binding peptides and radiation
EA016186B1 (en) 2005-09-26 2012-03-30 Медарекс, Инк. Human monoclonal antibodies to cd70 and use thereof
DK1939288T3 (en) 2005-09-29 2013-03-11 Eisai R&D Man Co Ltd T cell adhesion molecule and antibody directed against the molecule
WO2007043641A1 (en) 2005-10-14 2007-04-19 Fukuoka University Inhibitor of transplanted islet dysfunction in islet transplantation
BRPI0617664B8 (en) 2005-10-21 2021-05-25 Chugai Pharmaceutical Co Ltd use of an antibody recognizing IL-6 for the production of a pharmaceutical composition to treat myocardial infarction or suppress left ventricular remodeling after myocardial infarction
JP5006330B2 (en) 2005-10-21 2012-08-22 ノバルティス アーゲー Human antibodies against IL13 and therapeutic uses
CN101351221A (en) 2005-10-28 2009-01-21 明治制果株式会社 Outer coat protein PA5158 of pseudomonas aeruginosa
CA2629453C (en) 2005-11-10 2018-03-06 Curagen Corporation Method of treating ovarian and renal cancer using antibodies against t cell immunoglobulin domain and mucin domain 1 (tim-1) antigen
US8128934B2 (en) 2005-11-14 2012-03-06 Ribomic, Inc. Method for treatment or prevention of disease associated with functional disorder of regulatory T cell
AR057582A1 (en) 2005-11-15 2007-12-05 Nat Hospital Organization AGENTS TO DELETE INDUCTION OF CYTOTOXIC T LYMPHOCYTES
AR057941A1 (en) 2005-11-25 2007-12-26 Univ Keio THERAPEUTIC AGENTS FOR PROSTATE CANCER
JP2009518446A (en) 2005-12-07 2009-05-07 メダレックス インコーポレーティッド CTLA-4 antibody dose escalation regimen
JP5512128B2 (en) 2005-12-08 2014-06-04 メダレックス・リミテッド・ライアビリティ・カンパニー Human monoclonal antibodies against fucosyl GM1 and methods for using anti-fucosyl GM1
PT1979001E (en) 2005-12-13 2012-07-13 Medimmune Ltd Binding proteins specific for insulin-like growth factors and uses thereof
WO2007077934A1 (en) 2005-12-28 2007-07-12 Asubio Pharma Co., Ltd. Anti-periostin antibody and pharmaceutical composition for preventing or treating periostin-related disease containing the same
US9084777B2 (en) 2005-12-28 2015-07-21 Chugai Seiyaku Kabushiki Kaisha Stabilized antibody-containing formulations
AR056857A1 (en) 2005-12-30 2007-10-24 U3 Pharma Ag DIRECTED ANTIBODIES TO HER-3 (RECEIVER OF THE HUMAN EPIDERMAL GROWTH FACTOR-3) AND ITS USES
ES2586825T3 (en) 2006-01-12 2016-10-19 Alexion Pharmaceuticals, Inc. Antibodies for OX-2 / CD200 and their uses
EP1976883B1 (en) 2006-01-17 2012-10-03 Medarex, Inc. Monoclonal antibodies against cd30 lacking in fucosyl and xylosyl residues
EP3135298B1 (en) 2006-01-27 2018-06-06 Keio University Therapeutic agents for diseases involving choroidal neovascularization
SG170804A1 (en) 2006-03-30 2011-05-30 Meiji Seika Kaisha Pseudomonas aeruginosa outer membrane protein pa0427
WO2007117410A2 (en) 2006-03-31 2007-10-18 Medarex, Inc. Transgenic animals expressing chimeric antibodies for use in preparing human antibodies
WO2007118214A2 (en) 2006-04-07 2007-10-18 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Antibody compositions and methods for treatment of neoplastic disease
CN101495146B (en) 2006-04-07 2012-10-17 国立大学法人大阪大学 Muscle regeneration promoter
TW200813091A (en) 2006-04-10 2008-03-16 Amgen Fremont Inc Targeted binding agents directed to uPAR and uses thereof
WO2007129457A1 (en) 2006-04-25 2007-11-15 The University Of Tokyo Therapeutic agents for alzheimer's disease and cancer
DK2047863T3 (en) 2006-06-08 2013-09-16 Chugai Pharmaceutical Co Ltd MEDICINE FOR PREVENTION OR TREATMENT OF INFLAMMATORY DISEASES
AU2007259739B2 (en) 2006-06-14 2013-03-07 Chugai Seiyaku Kabushiki Kaisha Agents for promoting the growth of hematopoietic stem cells
CA2657385A1 (en) 2006-07-13 2008-01-17 Naoki Kimura Cell death inducer
JP5175729B2 (en) 2006-07-21 2013-04-03 中外製薬株式会社 Kidney disease treatment
TW200815474A (en) 2006-08-03 2008-04-01 Astrazeneca Ab Antibodies alphaVbeta6 and uses thereof
CL2007002225A1 (en) 2006-08-03 2008-04-18 Astrazeneca Ab SPECIFIC UNION AGENT FOR A RECEIVER OF THE GROWTH FACTOR DERIVED FROM PLATES (PDGFR-ALFA); NUCLEIC ACID MOLECULA THAT CODIFIES IT; VECTOR AND CELL GUESTS THAT UNDERSTAND IT; CONJUGADO UNDERSTANDING THE AGENT; AND USE OF THE AGENT OF A
WO2008020586A1 (en) 2006-08-14 2008-02-21 Forerunner Pharma Research Co., Ltd. Diagnosis and treatment of cancer using anti-desmoglein-3 antibody
BRPI0714893A2 (en) 2006-09-05 2013-05-28 Medarex Inc isolated monoclonal antibody or antigen-binding portion thereof, antibody fragment, mimetic antibody, immunoconjugate, isolated nucleic acid molecule composition, expression vector, host cell, method for preparing an anti-bmp2 or anti-bmp4 antibody, Method for treating or preventing a disease associated with normal bone formation and ossification, hybridoma and method for preparing the antibody
JPWO2008032833A1 (en) 2006-09-14 2010-01-28 株式会社医学生物学研究所 Antibody with enhanced ADCC activity and method for producing the same
DK2081595T3 (en) 2006-09-26 2019-07-15 Genmab As ANTI-CD38 PLUS CORTICOSTEROID PLUS A NON-CORTICOSTEROID KEMOTERAPEUTIKA FOR TUMOR TREATMENT
AU2007301599B2 (en) 2006-09-28 2013-01-10 Merck Serono S.A. Junctional Adhesion Molecule-C (JAM-C) binding compounds and methods of their use
ES2625798T3 (en) 2006-10-02 2017-07-20 E. R. Squibb & Sons, L.L.C. Human antibodies that bind to CXCR4 and their uses
CA2665528C (en) 2006-10-12 2018-01-23 The University Of Tokyo Diagnosis and treatment of cancer using anti-ereg antibody
US8613925B2 (en) 2006-10-19 2013-12-24 Csl Limited Anti-IL-13Rα1 antibodies and their uses thereof
JP5378795B2 (en) 2006-10-20 2013-12-25 中外製薬株式会社 Pharmaceutical composition comprising anti-HB-EGF antibody as an active ingredient
AU2007311946A1 (en) 2006-10-20 2008-04-24 Forerunner Pharma Research Co., Ltd. Anti-cancer agent comprising anti-HB-EGF antibody as active ingredient
AU2007334264A1 (en) 2006-11-15 2008-06-26 Medarex, Inc. Human monoclonal antibodies to BTLA and methods of use
EP2095826B1 (en) 2006-11-17 2012-12-26 The Research Foundation for Microbial Diseases of Osaka University Nerve elongation promoter and elongation inhibitor
CN101626782B (en) 2006-12-01 2013-03-27 梅达雷克斯公司 Human antibodies that bind cd22 and uses thereof
CL2007003622A1 (en) 2006-12-13 2009-08-07 Medarex Inc Human anti-cd19 monoclonal antibody; composition comprising it; and tumor cell growth inhibition method.
EP2103628A4 (en) 2006-12-14 2012-02-22 Forerunner Pharma Res Co Ltd Anti-claudin-3 monoclonal antibody, and treatment and diagnosis of cancer using the same
AU2007333098A1 (en) 2006-12-14 2008-06-19 Medarex, Inc. Human antibodies that bind CD70 and uses thereof
EP2123676A4 (en) 2007-01-05 2011-01-05 Univ Tokyo Diagnosis and treatment of cancer by using anti-prg-3 antibody
SG177982A1 (en) 2007-01-16 2012-02-28 Abbott Lab Methods for treating psoriasis
TWI438208B (en) 2007-01-23 2014-05-21 Chugai Pharmaceutical Co Ltd Agents for suppressing chronic rejection reaction
EP3246407B1 (en) 2007-02-09 2019-04-03 Eisai R&D Management Co., Ltd. Gaba neuron progenitor cell marker 65b13
JP5241518B2 (en) 2007-02-15 2013-07-17 国立大学法人九州大学 Interstitial lung disease therapeutic agent comprising anti-HMGB-1 antibody
EP3248617A3 (en) 2007-02-16 2018-02-21 Merrimack Pharmaceuticals, Inc. Antibodies against erbb3 and uses thereof
MX2009008706A (en) 2007-02-21 2009-09-14 Univ Massachusetts Human antibodies against hepatitis c virus (hcv) uses thereof.
JP5374360B2 (en) 2007-02-27 2013-12-25 中外製薬株式会社 Pharmaceutical composition comprising anti-GRP78 antibody as an active ingredient
CL2008000719A1 (en) 2007-03-12 2008-09-05 Univ Tokushima Chugai Seiyaku THERAPEUTIC AGENT FOR CANCER RESISTANT TO CHEMOTHERAPEUTIC AGENTS THAT UNDERSTAND AN ANTIBODY THAT RECOGNIZES IT CLASS I AS ACTIVE INGREDIENT; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH ANTIBODY; AND METHOD TO TREAT CANCER RESISTANT TO
CN103214577B (en) 2007-03-22 2015-09-02 生物基因Ma公司 Specific binding CD154 comprises associated proteins of antibody, antibody derivatives and antibody fragment and uses thereof
AU2008234248C1 (en) 2007-03-29 2015-01-22 Genmab A/S Bispecific antibodies and methods for production thereof
FI20075278A0 (en) 2007-04-20 2007-04-20 Biotie Therapies Corp Novel completely human anti-VAP-1 monoclonal antibodies
JP5117765B2 (en) 2007-05-28 2013-01-16 国立大学法人 東京大学 Tumor diagnostic agent for PET containing anti-ROBO1 antibody
US20100267934A1 (en) 2007-05-31 2010-10-21 Genmab A/S Stable igg4 antibodies
WO2008145140A2 (en) 2007-05-31 2008-12-04 Genmab A/S Transgenic animals producing monovalent human antibodies and antibodies obtainable from these animals
WO2008153926A2 (en) 2007-06-05 2008-12-18 Yale University Inhibitors of receptor tyrosine kinases and methods of use thereof
US8722858B2 (en) 2007-06-25 2014-05-13 Chugai Seiyaku Kabushiki Kaisha Anti-Prominin-1 antibody having ADCC activity or CDC activity
WO2009001940A1 (en) 2007-06-27 2008-12-31 Asubio Pharma Co., Ltd. Cancer remedy containing antibody against peptide encoded by exon-17 of periostin
WO2009008414A1 (en) 2007-07-10 2009-01-15 Shionogi & Co., Ltd. Monoclonal antibody having neutralizing activity against mmp13
JP5424330B2 (en) 2007-07-26 2014-02-26 国立大学法人大阪大学 A therapeutic agent for ocular inflammatory diseases comprising an interleukin 6 receptor inhibitor as an active ingredient
DK2185719T3 (en) 2007-08-02 2014-02-17 Novimmune Sa ANTI-RANTES ANTIBODIES AND PROCEDURES FOR USE THEREOF
EP2185692A4 (en) 2007-08-10 2012-05-02 Medarex Inc Hco32 and hco27 and related examples
WO2009025196A1 (en) 2007-08-20 2009-02-26 Oncotherapy Science, Inc. Foxm1 peptide and medicinal agent comprising the same
PL2186889T3 (en) 2007-08-20 2015-09-30 Oncotherapy Science Inc Cdca1 peptide and pharmaceutical agent comprising the same
JP5294271B2 (en) 2007-08-20 2013-09-18 オンコセラピー・サイエンス株式会社 CDH3 peptide and drug containing the same
US8865875B2 (en) 2007-08-22 2014-10-21 Medarex, L.L.C. Site-specific attachment of drugs or other agents to engineered antibodies with C-terminal extensions
EP2615114B1 (en) 2007-08-23 2022-04-06 Amgen Inc. Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
JOP20080381B1 (en) 2007-08-23 2023-03-28 Amgen Inc Antigen Binding Proteins to Proprotein Convertase subtillisin Kexin type 9 (pcsk9)
PL2769729T3 (en) 2007-09-04 2019-09-30 Compugen Ltd. Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics
EP2497783A3 (en) 2007-09-26 2013-04-17 U3 Pharma GmbH Heparin-binding epidermal growth factor-like growth factor antigen binding proteins
KR101601986B1 (en) 2007-10-02 2016-03-17 추가이 세이야쿠 가부시키가이샤 Remedy for graft-versus-host disease comprising interleukin-6 receptor inhibitor as the active ingredient
AR068767A1 (en) 2007-10-12 2009-12-02 Novartis Ag ANTIBODIES AGAINST SCLEROSTIN, COMPOSITIONS AND METHODS OF USE OF THESE ANTIBODIES TO TREAT A PATHOLOGICAL DISORDER MEDIATIONED BY SCLEROSTIN
MX2010004007A (en) 2007-10-15 2010-06-15 Chugai Pharmaceutical Co Ltd Method for production of antibody.
KR20100115340A (en) 2007-10-19 2010-10-27 이무나스 파마 가부시키가이샤 Antibody capable of specifically binding to aβ oligomer, and use thereof
EA201000718A1 (en) 2007-11-02 2011-06-30 Новартис Аг MOLECULES AND METHODS DESIGNED TO MODULATE THE RELATED LIPOPROTEIDES RECEPTOR OF LOW DENSITY PROTEIN 6 (LRP6)
ES2445755T3 (en) 2007-11-07 2014-03-05 Celldex Therapeutics, Inc. Antibodies that bind human dendritic and epithelial cells 205 (DEC-205)
ES2556214T3 (en) 2007-11-12 2016-01-14 U3 Pharma Gmbh AXL antibodies
AU2008321840B2 (en) 2007-11-14 2014-02-06 Chugai Seiyaku Kabushiki Kaisha Diagnosis and treatment of cancer using anti-GPR49 antibody
AR069333A1 (en) 2007-11-15 2010-01-13 Chugai Pharmaceutical Co Ltd MONOCLONAL ANTIBODIES THAT JOIN THE TIROSIN QUINASA ANEXELEKTO (AXL) RECEIVER, HYBRIDOMES THAT PRODUCE THEM AND THEIR USES
EP2241332A4 (en) 2007-12-05 2011-01-26 Chugai Pharmaceutical Co Ltd Therapeutic agent for pruritus
EP2236604B1 (en) 2007-12-05 2016-07-06 Chugai Seiyaku Kabushiki Kaisha Anti-nr10 antibody and use thereof
US20110262425A1 (en) 2007-12-12 2011-10-27 National Cancer Center Therapeutic agent for mll leukemia and moz leukemia of which molecular target is m-csf receptor, and use thereof
ES2483942T5 (en) 2007-12-14 2017-02-06 Novo Nordisk A/S Antibodies against human NKG2D and their uses
AU2008342152B2 (en) 2007-12-25 2013-06-27 Meiji Seika Pharma Co., Ltd. Component protein PA1698 for type-III secretion system of Pseudomonas aeruginosa
PE20091174A1 (en) 2007-12-27 2009-08-03 Chugai Pharmaceutical Co Ltd LIQUID FORMULATION WITH HIGH CONCENTRATION OF ANTIBODY CONTENT
EP2248826B1 (en) 2008-01-10 2013-06-12 Shionogi&Co., Ltd. Antibody directed against pcrv
US9274119B2 (en) 2008-01-11 2016-03-01 The University Of Tokyo Anti-CLDN6 antibody
CN102037007A (en) 2008-01-25 2011-04-27 奥尔胡斯大学 Selective exosite inhibition of PAPP-A activity against IGFBP-4
EP2641612A1 (en) 2008-02-05 2013-09-25 Bristol-Myers Squibb Company Alpha 5 - beta 1 antibodies and their uses
CN102936287B (en) 2008-02-08 2015-09-09 伊缪纳斯制药株式会社 Can the antibody of specific binding A beta oligomers and application thereof
EP2274333A4 (en) 2008-03-18 2011-06-15 Abbott Lab Methods for treating psoriasis
EP2260863A1 (en) 2008-03-27 2010-12-15 Takara Bio, Inc. Prophylactic/therapeutic agent for infectious disease
CL2009000647A1 (en) 2008-04-04 2010-06-04 Chugai Pharmaceutical Co Ltd Pharmaceutical composition for treating or preventing liver cancer comprising a combination of a chemotherapeutic agent and an anti-glypican 3 antibody; agent for attenuating a side effect comprising said antibody; method of treating or preventing liver cancer of a subject.
US9226934B2 (en) 2008-06-02 2016-01-05 The University Of Tokyo Anti-cancer drug
KR101665729B1 (en) 2008-06-05 2016-10-12 국립연구개발법인 고쿠리츠간켄큐센터 Neuroinvasion inhibitor
US8575314B2 (en) 2008-06-20 2013-11-05 National University Corporation Okayama University Antibody against oxidized LDL/β2GPI complex and use of the same
EP2815766B1 (en) 2008-08-05 2017-07-05 Novartis AG Compositions and methods for antibodies targeting complement protein C5
JP5692746B2 (en) 2008-08-07 2015-04-01 国立大学法人 長崎大学 Treatment or prevention of systemic pain syndrome
AR072999A1 (en) 2008-08-11 2010-10-06 Medarex Inc HUMAN ANTIBODIES THAT JOIN GEN 3 OF LYMPHOCYTARY ACTIVATION (LAG-3) AND THE USES OF THESE
MX2011001409A (en) 2008-08-14 2011-03-29 Cephalon Australia Pty Ltd Anti-il-12/il-23 antibodies.
CA2735900A1 (en) 2008-09-19 2010-03-25 Medimmune, Llc Antibodies directed to dll4 and uses thereof
DK2342226T3 (en) 2008-09-26 2016-09-26 Dana Farber Cancer Inst Inc HUMAN ANTI-PD-1, PD-L1 AND PD-L2 ANTIBODIES AND APPLICATIONS THEREOF
AU2009298458B2 (en) 2008-09-30 2015-10-08 Ablexis, Llc Non-human mammals for the production of chimeric antibodies
WO2010051288A1 (en) 2008-10-27 2010-05-06 Revivicor, Inc. Immunocompromised ungulates
PT2894165T (en) 2008-11-10 2023-03-17 Alexion Pharma Inc Methods and compositions for treating complement-associated disorders
AU2009324092A1 (en) 2008-12-03 2011-06-23 Genmab A/S Antibody variants having modifications in the constant region
EP2865689A1 (en) 2008-12-08 2015-04-29 Compugen Ltd. FAM26F polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics
UA109633C2 (en) 2008-12-09 2015-09-25 HUMAN ANTIBODY AGAINST TISSUE FACTOR
AU2009329365B2 (en) * 2008-12-18 2016-01-14 Roger Kingdon Craig Non-human transgenic animals expressing humanised antibodies and use thereof
JP5756292B2 (en) 2008-12-22 2015-07-29 中外製薬株式会社 Anti-HS6ST2 antibody and use thereof
US8877449B2 (en) 2008-12-22 2014-11-04 Eisai R&D Management Co., Ltd. Method for obtaining pancreatic progenitor cell using NEPH3
JP2012513194A (en) 2008-12-23 2012-06-14 アストラゼネカ アクチボラグ Targeted binding agents directed to α5β1 and uses thereof
EP2385114A4 (en) 2008-12-25 2012-08-08 Univ Tokyo Diagnosis of treatment of cancer using anti-tm4sf20 antibody
WO2010074192A1 (en) 2008-12-26 2010-07-01 国立大学法人東京大学 Diagnosis and treatment of cancer using anti-lgr7 antibody
EA028336B1 (en) 2009-03-05 2017-11-30 МЕДАРЕКС Л.Л.Си. Fully human antibodies specific to cadm1
JP2010210772A (en) 2009-03-13 2010-09-24 Dainippon Screen Mfg Co Ltd Method of manufacturing liquid crystal display device
JPWO2010110346A1 (en) 2009-03-24 2012-10-04 独立行政法人理化学研究所 Leukemia stem cell marker
WO2010112034A2 (en) 2009-04-02 2010-10-07 Aarhus Universitet Compositions and methods for treatment and diagnosis of synucleinopathies
CA2762187C (en) 2009-04-08 2017-08-01 Olle Hernell New methods for treatment of inflammatory diseases
WO2010119691A1 (en) 2009-04-16 2010-10-21 国立大学法人東京大学 Diagnosis and treatment of cancer using anti-tmprss11e antibody
JP5812418B2 (en) 2009-04-17 2015-11-11 イムナス・ファーマ株式会社 Antibody specifically binding to Aβ oligomer and use thereof
US9062116B2 (en) 2009-04-23 2015-06-23 Infinity Pharmaceuticals, Inc. Anti-fatty acid amide hydrolase-2 antibodies and uses thereof
EA201101572A1 (en) 2009-04-27 2012-05-30 Новартис Аг COMPOSITIONS AND METHODS OF APPLICATION OF THERAPEUTIC ANTIBODIES SPECIFIC TO THE SUB-UNIT OF BETA1 IL-12 RECEPTOR
MA33279B1 (en) 2009-04-27 2012-05-02 Novartis Ag COMPOSITIONS AND METHODS FOR INCREASING MUSCLE GROWTH
EP2426149A4 (en) 2009-05-01 2013-01-23 Univ Tokyo Anti-cadherin antibody
PL2448970T3 (en) 2009-05-04 2014-12-31 Abbvie Res B V Antibodies against nerve growth factor (ngf) with enhanced in vivo stability
CN104974250A (en) 2009-05-05 2015-10-14 诺维莫尼公司 Anti-il-17f antibodies and methods of use thereof
WO2010137654A1 (en) 2009-05-29 2010-12-02 株式会社未来創薬研究所 Pharmaceutical composition containing antagonist of egf family ligand as component
WO2010151632A1 (en) 2009-06-25 2010-12-29 Bristol-Myers Squibb Company Protein purifacation by caprylic acid (octanoic acid ) precipitation
HUE055817T2 (en) 2009-07-08 2021-12-28 Kymab Ltd Animal models and therapeutic molecules
US20120204278A1 (en) 2009-07-08 2012-08-09 Kymab Limited Animal models and therapeutic molecules
US9445581B2 (en) 2012-03-28 2016-09-20 Kymab Limited Animal models and therapeutic molecules
MY161541A (en) 2009-07-31 2017-04-28 Shin Maeda Cancer metastasis inhibitor
EP2459594A1 (en) 2009-07-31 2012-06-06 N.V. Organon Fully human antibodies to btla
ES2624835T3 (en) 2009-08-06 2017-07-17 Immunas Pharma, Inc. Antibodies that specifically bind to the A beta oligomers and use thereof
DK2462162T3 (en) 2009-08-06 2017-01-16 Immunas Pharma Inc Antibodies that specifically bind to A-beta oligomers and their use
WO2011017294A1 (en) 2009-08-07 2011-02-10 Schering Corporation Human anti-rankl antibodies
CN102574917A (en) 2009-08-17 2012-07-11 株式会社未来创药研究所 Pharmaceutical composition containing anti-HB-EGF antibody as active ingredient
WO2011021146A1 (en) 2009-08-20 2011-02-24 Pfizer Inc. Osteopontin antibodies
RU2012114854A (en) 2009-09-14 2013-10-27 Эбботт Лэборетриз METHODS FOR TREATING PSORIASIS
US20120178910A1 (en) 2009-09-23 2012-07-12 Medarex, Inc. Cation exchange chromatography (methods)
TW201118166A (en) 2009-09-24 2011-06-01 Chugai Pharmaceutical Co Ltd HLA class I-recognizing antibodies
RU2012124090A (en) 2009-11-09 2013-12-20 Алексион Фармасьютикалз, Инк. REAGENTS AND METHODS FOR DETERMINING TYPE II CELLS AT PNH
CA2778953C (en) 2009-11-13 2020-01-14 Dana-Farber Cancer Institute, Inc. Compositions, kits, and methods for the diagnosis, prognosis, monitoring, treatment and modulation of post-transplant lymphoproliferative disorders and hypoxia associated angiogenesis disorders using galectin-1
TWI630916B (en) 2009-11-13 2018-08-01 第一三共歐洲公司 Materials and methods for treating or preventing her-3 associated diseases
EP3431608A3 (en) 2009-11-17 2019-02-20 E. R. Squibb & Sons, L.L.C. Method for enhanced protein production
EP3279215B1 (en) 2009-11-24 2020-02-12 MedImmune Limited Targeted binding agents against b7-h1
US9428586B2 (en) 2009-12-01 2016-08-30 Compugen Ltd Heparanase splice variant
MX2012008108A (en) 2010-01-11 2012-10-03 Alexion Pharma Inc Biomarkers of immunomodulatory effects in humans treated with anti-cd200 antibodies.
TWI609698B (en) 2010-01-20 2018-01-01 Chugai Pharmaceutical Co Ltd Stabilized antibody-containing solution preparation
TR201806936T4 (en) 2010-01-29 2018-06-21 Chugai Pharmaceutical Co Ltd Anti-dll3 antibody.
SI3095871T1 (en) * 2010-02-08 2019-06-28 Regeneron Pharmaceuticals, Inc. Common light chain mouse
US20130045492A1 (en) 2010-02-08 2013-02-21 Regeneron Pharmaceuticals, Inc. Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
US9796788B2 (en) 2010-02-08 2017-10-24 Regeneron Pharmaceuticals, Inc. Mice expressing a limited immunoglobulin light chain repertoire
RU2577125C2 (en) 2010-02-10 2016-03-10 Фуджифилм Ри Фарма Ко., Лтд. Radioactive metal-labelled anti-cadherin antibody
EP2533810B1 (en) 2010-02-10 2016-10-12 ImmunoGen, Inc. Cd20 antibodies and uses thereof
US20120321557A1 (en) 2010-02-26 2012-12-20 Forerunner Pharma Research Co., Ltd. Anti-icam3 antibody and use thereof
JP5889181B2 (en) 2010-03-04 2016-03-22 中外製薬株式会社 Antibody constant region variants
CN103003307B (en) 2010-03-10 2017-08-11 根马布股份公司 Anti- c MEt monoclonal antibody
JP2013522313A (en) 2010-03-17 2013-06-13 アボツト・リサーチ・ベー・フエー Anti-nerve growth factor (NGF) antibody composition
CN107098958B (en) 2010-03-26 2021-11-05 达特茅斯大学理事会 VISTA regulatory T cell mediator protein, VISTA binding agent and uses thereof
US20150231215A1 (en) 2012-06-22 2015-08-20 Randolph J. Noelle VISTA Antagonist and Methods of Use
US10745467B2 (en) 2010-03-26 2020-08-18 The Trustees Of Dartmouth College VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders
LT3248462T (en) 2010-03-31 2024-05-27 Ablexis, Llc Genetic engineering of mice for the production of chimeric antibodies
EA024701B1 (en) 2010-04-13 2016-10-31 Селлдекс Терапьютикс Инк. Antibodies that bind human cd27 and uses thereof
MX353144B (en) 2010-04-20 2017-12-20 Genmab As Heterodimeric antibody fc-containing proteins and methods for production thereof.
US9011852B2 (en) 2010-04-30 2015-04-21 Alexion Pharmaceuticals, Inc. Anti-C5a antibodies
WO2011140151A1 (en) 2010-05-04 2011-11-10 Dyax Corp. Antibodies against epidermal growth factor receptor (egfr)
SG185366A1 (en) 2010-05-04 2012-12-28 Merrimack Pharmaceuticals Inc Antibodies against epidermal growth factor receptor (egfr) and uses thereof
ES2949159T3 (en) 2010-05-06 2023-09-26 Novartis Ag Compositions and methods of use for low-density lipoprotein-related protein 6 (LRP6) therapeutic antibodies
KR20130066631A (en) 2010-05-06 2013-06-20 노파르티스 아게 Compositions and methods of use for therapeutic low density lipoprotein - related protein 6 (lrp6) multivalent antibodies
CN103153339B (en) 2010-05-27 2021-05-04 根马布股份公司 Monoclonal antibody directed against HER2 epitope
CA3051311A1 (en) 2010-05-27 2011-12-01 Genmab A/S Monoclonal antibodies against her2
DK2578231T3 (en) 2010-05-28 2022-12-12 Chugai Pharmaceutical Co Ltd ANTI-TUMOR T-CELL RESPONSE AMPLIFIER
WO2011149046A1 (en) 2010-05-28 2011-12-01 独立行政法人国立がん研究センター Therapeutic agent for pancreatic cancer
EP2580243B1 (en) 2010-06-09 2019-10-16 Genmab A/S Antibodies against human cd38
BR112012031727B1 (en) 2010-06-15 2022-03-29 Genmab A/S DRUG-ANTIBODY CONJUGATE, PHARMACEUTICAL COMPOSITION, AND, USE OF DRUG-ANTIBODY CONJUGATE
AU2011270959A1 (en) 2010-06-22 2013-01-10 Musc Foundation For Research Development Antibodies to the C3d fragment of complement component 3
EP3327035A1 (en) 2010-06-22 2018-05-30 Precision Biologics Inc. Colon and pancreas cancer specific antigens and antibodies
US9485812B2 (en) 2010-07-08 2016-11-01 Honda Motor Co., Ltd. High frequency heating coil
KR20130097156A (en) 2010-07-26 2013-09-02 트리아니, 인코포레이티드 Transgenic animals and methods of use
US10662256B2 (en) 2010-07-26 2020-05-26 Trianni, Inc. Transgenic mammals and methods of use thereof
US10793829B2 (en) 2010-07-26 2020-10-06 Trianni, Inc. Transgenic mammals and methods of use thereof
DK2601298T3 (en) 2010-08-02 2017-02-27 Regeneron Pharma Mice generating binding proteins comprising VL domains
WO2012018404A2 (en) 2010-08-06 2012-02-09 U3 Pharma Gmbh Use of her3 binding agents in prostate treatment
PT2606070T (en) 2010-08-20 2017-03-31 Novartis Ag Antibodies for epidermal growth factor receptor 3 (her3)
US8999335B2 (en) 2010-09-17 2015-04-07 Compugen Ltd. Compositions and methods for treatment of drug resistant multiple myeloma
AR083035A1 (en) 2010-09-17 2013-01-30 Baxter Int STABILIZATION OF IMMUNOGLOBULINS THROUGH A WATERY FORMULATION WITH HISTIDINE AT WEAK ACID pH NEUTRAL, WATER COMPOSITION OF IMMUNOGLOBULIN
US9068014B2 (en) 2010-09-23 2015-06-30 Precision Biologics, Inc. Colon and pancreas cancer peptidomimetics
WO2012043747A1 (en) 2010-09-30 2012-04-05 独立行政法人理化学研究所 Glioma treatment method, glioma examination method, method of delivering a desired material to a glioma, and drug used in said methods
CN103154037A (en) 2010-10-05 2013-06-12 诺瓦提斯公司 Anti-IL 12 Rbeta 1 antibodies and their use in treating autoimmune and inflammatory disorders
BR112013010136A2 (en) 2010-10-25 2019-09-24 Univ Minnesota vaccine, therapeutic composition and methods for the treatment or inhibition of gliblastoma
PT2634194T (en) 2010-10-29 2018-10-19 Perseus Proteomics Inc Anti-cdh3 antibody having high internalization capacity
EP2644698B1 (en) 2010-11-17 2018-01-03 Chugai Seiyaku Kabushiki Kaisha Multi-specific antigen-binding molecule having alternative function to function of blood coagulation factor viii
EP2643353A1 (en) 2010-11-24 2013-10-02 Novartis AG Multispecific molecules
RU2663123C2 (en) 2010-11-30 2018-08-01 Чугаи Сейяку Кабусики Кайся Cytotoxicity-inducing therapeutic agent
CN108715614A (en) 2010-11-30 2018-10-30 中外制药株式会社 The antigen binding molecules combined are repeated with polymolecular antigen
US9085772B2 (en) 2010-12-27 2015-07-21 National University Corporation Nagoya University Method for suppressing receptor tyrosine kinase-mediated pro-survival signaling in cancer cell
SG10201600531TA (en) 2011-01-24 2016-02-26 Univ Singapore Pathogenic mycobacteria-derived mannose-capped lipoarabinomannan antigen binding proteins
AU2012212066A1 (en) 2011-02-03 2013-08-15 Alexion Pharmaceuticals, Inc. Use of an anti-CD200 antibody for prolonging the survival of allografts
WO2012133782A1 (en) 2011-03-30 2012-10-04 中外製薬株式会社 Retention of antigen-binding molecules in blood plasma and method for modifying immunogenicity
BR112013021526B1 (en) 2011-02-25 2021-09-21 Chugai Seiyaku Kabushiki Kaisha VARIANT POLYPEPTIDE, METHODS FOR MAINTAINING OR DECREASE BINDING ACTIVITIES TO FCGRIIA (TYPE R) AND FCGRIIA (TYPE H) AND INCREASING FCGRIIB BINDING ACTIVITY OF A POLYPEPTIDE AND FOR SUPPRESSING THE PRODUCTION OF AN ANTIBODY AGAINST A POLYENDENDOPEPTIDE ANTIBODY FC, METHODS FOR THE PRODUCTION OF SUCH POLYPEPTIDE WITH MAINTAINED OR DECREASED AND INCREASED BINDING ACTIVITIES AND FOR THE SUPPRESSED PRODUCTION OF AN ANTIBODY, PHARMACEUTICAL COMPOSITION AND USE OF A POLYPEPTIDE
WO2012118693A1 (en) 2011-02-28 2012-09-07 Northshore University Healthsystem Methods of diagnosing clostridium difficile infection
JP5948683B2 (en) 2011-02-28 2016-07-06 国立研究開発法人国立循環器病研究センター Medicament for inhibiting malignant tumor metastasis
AU2012240231B2 (en) 2011-04-04 2017-05-25 University Of Iowa Research Foundation Methods of improving vaccine immunogenicity
AU2012239997A1 (en) 2011-04-07 2013-10-17 Amgen Inc. Novel EGFR binding proteins
WO2012136552A1 (en) 2011-04-08 2012-10-11 H. Lundbeck A/S ANTIBODIES SPECIFIC TO PYROGLUTAMATED Αβ
US9150644B2 (en) 2011-04-12 2015-10-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human monoclonal antibodies that bind insulin-like growth factor (IGF) I and II
CN105601741A (en) 2011-04-15 2016-05-25 卡姆普根有限公司 Polypeptides and polynucleotides, and uses thereof for treatment of immune related disorders and cancer
WO2012144208A1 (en) 2011-04-18 2012-10-26 国立大学法人東京大学 Diagnosis and treatment of cancer using anti-itm2a antibody
CN103796678B (en) 2011-04-20 2018-02-27 健玛保 For HER2 bispecific antibody
JP2014514314A (en) 2011-04-20 2014-06-19 ゲンマブ エー／エス Bispecific antibodies against HER2 and CD3
EP2702077A2 (en) 2011-04-27 2014-03-05 AbbVie Inc. Methods for controlling the galactosylation profile of recombinantly-expressed proteins
JOP20200043A1 (en) 2011-05-10 2017-06-16 Amgen Inc Methods of treating or preventing cholesterol related disorders
CN107936121B (en) 2011-05-16 2022-01-14 埃泰美德(香港)有限公司 Multispecific FAB fusion proteins and methods of use thereof
KR102046666B1 (en) 2011-05-25 2019-11-19 이나뜨 파르마 Anti-kir antibodies for the treatment of inflammatory disorders
US8691231B2 (en) 2011-06-03 2014-04-08 Merrimack Pharmaceuticals, Inc. Methods of treatment of tumors expressing predominantly high affinity EGFR ligands or tumors expressing predominantly low affinity EGFR ligands with monoclonal and oligoclonal anti-EGFR antibodies
WO2012172495A1 (en) 2011-06-14 2012-12-20 Novartis Ag Compositions and methods for antibodies targeting tem8
US9890218B2 (en) 2011-06-30 2018-02-13 Chugai Seiyaku Kabushiki Kaisha Heterodimerized polypeptide
AU2012277376B2 (en) 2011-06-30 2016-11-24 Compugen Ltd. Polypeptides and uses thereof for treatment of autoimmune disorders and infection
HUE040276T2 (en) 2011-07-01 2019-02-28 Novartis Ag Method for treating metabolic disorders
US10323081B2 (en) 2011-07-06 2019-06-18 Genmag A/S Modulation of complement-dependent cytotoxicity through modifications of the C-terminus of antibody heavy chains
UA117901C2 (en) 2011-07-06 2018-10-25 Ґенмаб Б.В. Antibody variants and uses thereof
US9238689B2 (en) 2011-07-15 2016-01-19 Morpho Sys AG Antibodies that are cross-reactive for macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (D-DT)
US9156911B2 (en) 2011-07-18 2015-10-13 Amgen Inc. Apelin antigen-binding proteins and uses thereof
WO2013012022A1 (en) 2011-07-19 2013-01-24 中外製薬株式会社 Stable protein-containing preparation containing argininamide or analogous compound thereof
WO2013017656A1 (en) 2011-08-02 2013-02-07 Medizinische Universität Wien Antagonists of ribonucleases for treating obesity
WO2013017691A1 (en) 2011-08-04 2013-02-07 Medizinische Universität Innsbruck Cahgt1p inhibitors for use in the treatment of candidiasis
RS61946B1 (en) 2011-08-05 2021-07-30 Regeneron Pharma Humanized universal light chain mice
JP5925783B2 (en) 2011-08-12 2016-05-25 国立感染症研究所長 Methods and compositions for testing, prevention and treatment of Aspergillus fumigatus infections
EP2749572A4 (en) 2011-08-23 2015-04-01 Chugai Pharmaceutical Co Ltd Novel anti-ddr1 antibody having anti-tumor activity
WO2013035824A1 (en) 2011-09-07 2013-03-14 ファーマロジカルズ・リサーチ プライベート リミテッド Cancer stem cell isolation
CA2846319A1 (en) 2011-09-19 2013-03-28 Kymab Limited Antibodies, variable domains & chains tailored for human use
WO2013045916A1 (en) 2011-09-26 2013-04-04 Kymab Limited Chimaeric surrogate light chains (slc) comprising human vpreb
WO2013047752A1 (en) 2011-09-30 2013-04-04 中外製薬株式会社 Antigen-binding molecule for promoting loss of antigens
US10024867B2 (en) 2011-09-30 2018-07-17 Chugai Seiyaku Kabushiki Kaisha Ion concentration-dependent binding molecule library
MX366968B (en) 2011-09-30 2019-08-01 Chugai Pharmaceutical Co Ltd Antigen-binding molecule inducing immune response to target antigen.
JP6271251B2 (en) 2011-10-05 2018-01-31 中外製薬株式会社 An antigen-binding molecule that promotes elimination of an antigen containing a sugar chain receptor-binding domain from plasma
EP2766033B1 (en) 2011-10-14 2019-11-20 Novartis AG Antibodies and methods for wnt pathway-related diseases
EP3216871B1 (en) 2011-10-17 2021-12-22 Regeneron Pharmaceuticals, Inc. Restricted immunoglobulin heavy chain mice
AU2012328322A1 (en) 2011-10-27 2014-06-12 Genmab A/S Production of heterodimeric proteins
US20140302511A1 (en) 2011-10-28 2014-10-09 Pharmalogicals Research Pte. Ltd. Cancer stem cell-specific molecule
AU2012332593B2 (en) 2011-11-01 2016-11-17 Bionomics, Inc. Anti-GPR49 antibodies
ES2697674T3 (en) 2011-11-01 2019-01-25 Bionomics Inc Procedures to block the growth of cancer stem cells
CN104053671A (en) 2011-11-01 2014-09-17 生态学有限公司 Antibodies and methods of treating cancer
AU2012332590B2 (en) 2011-11-01 2016-10-20 Bionomics, Inc. Anti-GPR49 antibodies
CN104168922A (en) 2011-11-16 2014-11-26 安姆根有限公司 Methods of treating epidermal growth factor deletion mutant VIII related disorders
BR112014013081A2 (en) 2011-11-30 2020-10-20 Chugai Seiyaku Kabushiki Kaisha drug-containing cell vehicle for formation of an immune complex
US9253965B2 (en) 2012-03-28 2016-02-09 Kymab Limited Animal models and therapeutic molecules
KR102083957B1 (en) 2011-12-05 2020-03-04 노파르티스 아게 Antibodies for epidermal growth factor receptor 3 (her3)
KR20140103135A (en) 2011-12-05 2014-08-25 노파르티스 아게 Antibodies for epidermal growth factor receptor 3 (her3) directed to domain ii of her3
AU2012356170B2 (en) 2011-12-21 2016-06-16 Novartis Ag Compositions and methods for antibodies targeting Factor P
TWI593705B (en) 2011-12-28 2017-08-01 Chugai Pharmaceutical Co Ltd Humanized anti-epiregulin antibody and cancer therapeutic agent containing the antibody as an active ingredient
CN104185681A (en) 2012-02-01 2014-12-03 卡姆普根有限公司 C10RF32 antibodies, and uses thereof for treatment of cancer
PT2812443T (en) 2012-02-06 2019-09-05 Inhibrx Inc Cd47 antibodies and methods of use thereof
SG11201404751UA (en) 2012-02-09 2014-09-26 Chugai Pharmaceutical Co Ltd Modified fc region of antibody
US20160046693A1 (en) 2012-02-24 2016-02-18 Chugai Seiyaku Kabushiki Kaisha Antigen-Binding Molecule for Promoting Disappearance of Antigen via Fc gamma RIIB
US10251377B2 (en) 2012-03-28 2019-04-09 Kymab Limited Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
GB2502127A (en) 2012-05-17 2013-11-20 Kymab Ltd Multivalent antibodies and in vivo methods for their production
JP6280031B2 (en) 2012-03-29 2018-02-14 中外製薬株式会社 Anti-LAMP5 antibody and use thereof
WO2013150623A1 (en) 2012-04-04 2013-10-10 株式会社ペルセウスプロテオミクス Conjugate of anti-cdh3 (p-cadherin) antibody and drug
WO2013158279A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Protein purification methods to reduce acidic species
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
US9181572B2 (en) 2012-04-20 2015-11-10 Abbvie, Inc. Methods to modulate lysine variant distribution
EA039663B1 (en) 2012-05-03 2022-02-24 Амген Инк. Use of an anti-pcsk9 antibody for lowering serum cholesterol ldl and treating cholesterol related disorders
US9416189B2 (en) 2012-05-11 2016-08-16 Microbial Chemistry Research Foundation Anti-CXADR antibody
WO2013176754A1 (en) 2012-05-24 2013-11-28 Abbvie Inc. Novel purification of antibodies using hydrophobic interaction chromatography
ES2856272T3 (en) 2012-05-30 2021-09-27 Chugai Pharmaceutical Co Ltd Antigen-binding molecule to remove aggregated antigens
RU2743463C2 (en) 2012-05-30 2021-02-18 Чугаи Сейяку Кабусики Кайся Antigen-binding molecule specific to target tissue
SG10201609535TA (en) * 2012-06-05 2017-01-27 Regeneron Pharma Methods for making fully human bispecific antibodies using a common light chain
MX2014015195A (en) 2012-06-11 2015-02-17 Amgen Inc Dual receptor antagonistic antigen-binding proteins and uses thereof.
EP3597037B1 (en) 2012-06-12 2021-04-28 Regeneron Pharmaceuticals, Inc. Humanized non-human animals with restricted immunoglobulin heavy chain loci
JP6628966B2 (en) 2012-06-14 2020-01-15 中外製薬株式会社 Antigen binding molecule containing an altered Fc region
US9890215B2 (en) 2012-06-22 2018-02-13 King's College London Vista modulators for diagnosis and treatment of cancer
EP2864352B1 (en) 2012-06-22 2018-08-08 The Trustees Of Dartmouth College Novel vista-ig constructs and the use of vista-ig for treatment of autoimmune, allergic and inflammatory disorders
UY34887A (en) 2012-07-02 2013-12-31 Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware OPTIMIZATION OF ANTIBODIES THAT FIX THE LYMPHOCYTE ACTIVATION GEN 3 (LAG-3) AND ITS USES
CN104736174B (en) 2012-07-06 2019-06-14 根马布私人有限公司 Protein dimer with triple mutant
EP3632462A1 (en) 2012-07-06 2020-04-08 Genmab B.V. Dimeric protein with triple mutations
WO2014007402A1 (en) 2012-07-06 2014-01-09 京都府公立大学法人 Differentiation marker for and differentiation control for ocular cells
WO2014021339A1 (en) 2012-07-30 2014-02-06 国立大学法人名古屋大学 Monoclonal antibody against human midkine
CA2882272C (en) 2012-08-24 2023-08-29 Chugai Seiyaku Kabushiki Kaisha Fc.gamma.riib-specific fc region variant
EP3597747B1 (en) 2012-08-24 2023-03-15 Chugai Seiyaku Kabushiki Kaisha Mouse fcgammarii-specific fc antibody
AU2013309506A1 (en) 2012-09-02 2015-03-12 Abbvie Inc. Methods to control protein heterogeneity
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
JOP20200308A1 (en) 2012-09-07 2017-06-16 Novartis Ag IL-18 binding molecules
CA2884704C (en) 2012-09-07 2023-04-04 Randolph J. Noelle Vista modulators for diagnosis and treatment of cancer
WO2014042251A1 (en) 2012-09-13 2014-03-20 中外製薬株式会社 Gene knock-in non-human animal
EA031631B1 (en) 2012-09-27 2019-01-31 Чугаи Сеияку Кабушики Каиша Method for treating or preventing cancer, method for selecting a patient, method for testing cancer predisposition in a subject, fusion polypeptide and uses thereof
CA2886326C (en) 2012-09-28 2021-11-02 Chugai Seiyaku Kabushiki Kaisha Method for evaluating blood coagulation reaction
EP3489258A1 (en) 2012-11-08 2019-05-29 Eleven Biotherapeutics, Inc. Il-6 antagonists and uses thereof
ES2689782T3 (en) 2012-11-08 2018-11-15 University Of Miyazaki Antibody capable of specifically recognizing a transferrin receptor
WO2014084859A1 (en) 2012-11-30 2014-06-05 Novartis Ag Molecules and methods for modulating tmem16a activities
PT2928921T (en) 2012-12-05 2021-04-06 Novartis Ag Compositions and methods for antibodies targeting epo
EP2935589A1 (en) 2012-12-18 2015-10-28 Novartis AG Compositions and methods that utilize a peptide tag that binds to hyaluronan
ES2876009T3 (en) 2012-12-27 2021-11-11 Chugai Pharmaceutical Co Ltd Heterodimerized polypeptide
US9938344B2 (en) 2012-12-28 2018-04-10 Precision Biologics, Inc. Humanized monoclonal antibodies and methods of use for the diagnosis and treatment of colon and pancreas cancer
KR20160007478A (en) 2013-01-10 2016-01-20 젠맵 비. 브이 Human igg1 fc region variants and uses thereof
EP2948478B1 (en) 2013-01-25 2019-04-03 Amgen Inc. Antibodies targeting cdh19 for melanoma
JO3519B1 (en) 2013-01-25 2020-07-05 Amgen Inc Antibody constructs for CDH19 and CD3
EP4137518A1 (en) 2013-02-06 2023-02-22 Inhibrx, Inc. Non-platelet depleting and non-red blood cell depleting cd47 antibodies and methods of use thereof
UY35315A (en) 2013-02-08 2014-09-30 Novartis Ag ANTI-IL-17A ANTIBODIES AND ITS USE IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS
JP6357113B2 (en) 2013-02-08 2018-07-11 株式会社医学生物学研究所 Antibodies against human NRG1 protein
DK2840892T3 (en) 2013-02-20 2018-07-23 Regeneron Pharma Non-human animals with modified heavy chain immunoglobulin sequences
US9429584B2 (en) 2013-02-28 2016-08-30 National Cancer Center Antibody against insoluble fibrin
WO2014136910A1 (en) 2013-03-08 2014-09-12 国立大学法人大阪大学 ANTIBODY TO PEPTIDE ENCODED BY Exon-21 OF PERIOSTIN, AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF INFLAMMATORY DISEASE CONTAINING SAID ANTIBODY
AU2013381687A1 (en) 2013-03-12 2015-09-24 Abbvie Inc. Human antibodies that bind human TNF-alpha and methods of preparing the same
US8921526B2 (en) 2013-03-14 2014-12-30 Abbvie, Inc. Mutated anti-TNFα antibodies and methods of their use
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
WO2014159239A2 (en) 2013-03-14 2014-10-02 Novartis Ag Antibodies against notch 3
WO2014151878A2 (en) 2013-03-14 2014-09-25 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
LT2970449T (en) 2013-03-15 2019-11-25 Amgen Res Munich Gmbh Single chain binding molecules comprising n-terminal abp
US9505849B2 (en) 2013-03-15 2016-11-29 Amgen Research (Munich) Gmbh Antibody constructs for influenza M2 and CD3
US9788534B2 (en) 2013-03-18 2017-10-17 Kymab Limited Animal models and therapeutic molecules
AU2014250434B2 (en) 2013-04-02 2019-08-08 Chugai Seiyaku Kabushiki Kaisha Fc region variant
WO2014174596A1 (en) 2013-04-23 2014-10-30 株式会社医学生物学研究所 Functional monoclonal antibody against heparin-binding epidermal growth factor-like growth factor
US9783593B2 (en) 2013-05-02 2017-10-10 Kymab Limited Antibodies, variable domains and chains tailored for human use
US11707056B2 (en) 2013-05-02 2023-07-25 Kymab Limited Animals, repertoires and methods
CA2912526C (en) 2013-05-16 2021-09-14 Kyoto University Method for determining prognosis of cancer
WO2014186877A1 (en) 2013-05-24 2014-11-27 Uger Marni Diane FasR ANTIBODIES FOR DIAGNOSTIC AND THERAPEUTIC USE
US10782290B2 (en) 2013-06-11 2020-09-22 National Center Of Neurology And Psychiatry Method for predicting post-therapy prognosis of relapsing-remitting multiple sclerosis (RRMS) patient, and method for determining applicability of novel therapy
AR096601A1 (en) 2013-06-21 2016-01-20 Novartis Ag ANTIBODIES OF LEXINED OXIDATED LDL RECEIVER 1 AND METHODS OF USE
BR112015032414A2 (en) 2013-06-24 2017-11-07 Chugai Pharmaceutical Co Ltd therapeutic agent comprising humanized antiepyrregulin antibody as active ingredient for non-small cell lung carcinoma excluding adenocarcinoma
CA2916259C (en) 2013-06-28 2024-02-20 Amgen Inc. Methods for treating homozygous familial hypercholesterolemia
BR112016002198A2 (en) 2013-08-14 2017-09-12 Novartis Ag Methods of treating sporadic inclusion body myositis
EP3033356B1 (en) 2013-08-14 2020-01-15 Sachdev Sidhu Antibodies against frizzled proteins and methods of use thereof
US20160193308A1 (en) 2013-09-04 2016-07-07 Osaka University Dpp-4-targeting vaccine for treating diabetes
US20160229922A1 (en) 2013-09-20 2016-08-11 Chugai Seiyaku Kabushiki Kaisha Treatment for hemorrhagic diseases by anti-protein-c antibody
TW201546284A (en) 2013-10-01 2015-12-16 Kymab Ltd Animal models and therapeutic molecules
EP3052640A2 (en) 2013-10-04 2016-08-10 AbbVie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
EP3070167A4 (en) 2013-11-06 2017-06-07 Osaka University Antibody having broad neutralizing activity in group 1 influenza a virus
CA2929044A1 (en) 2013-11-11 2015-05-14 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule containing modified antibody variable region
WO2015073884A2 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
EP3763813A1 (en) 2013-12-04 2021-01-13 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecules, the antigen-binding activity of which varies according to the concentration of compounds, and libraries of said molecules
US11014987B2 (en) 2013-12-24 2021-05-25 Janssen Pharmaceutics Nv Anti-vista antibodies and fragments, uses thereof, and methods of identifying same
MX369173B (en) 2013-12-24 2019-10-30 Janssen Pharmaceutica Nv Anti-vista antibodies and fragments.
KR101836756B1 (en) 2013-12-27 2018-03-08 오사카 유니버시티 Vaccine targeting il-17a
MX2016008498A (en) 2013-12-27 2016-10-07 Chugai Pharmaceutical Co Ltd Method for purifying antibody having low isoelectric point.
TW201609093A (en) 2013-12-27 2016-03-16 Chugai Pharmaceutical Co Ltd Fgfr gatekeeper mutant gene and drug targeting same
US10106623B2 (en) 2014-02-12 2018-10-23 Michael Uhlin Bispecific antibodies for use in stem cell transplantation
US10881085B2 (en) 2014-03-21 2021-01-05 Regeneron Pharmaceuticals, Inc. Non-human animals that make single domain binding proteins
SG10201808083VA (en) 2014-03-21 2018-10-30 Regeneron Pharma Vl antigen binding proteins exhibiting distinct binding characteristics
SG11201607772WA (en) 2014-03-31 2016-10-28 Debiopharm Int Sa Fgfr fusions
KR102352573B1 (en) 2014-04-04 2022-01-18 바이오노믹스 인코포레이티드 Humanized antibodies that bind lgr5
TW201622746A (en) 2014-04-24 2016-07-01 諾華公司 Methods of improving or accelerating physical recovery after surgery for hip fracture
SG10201810507WA (en) 2014-06-06 2018-12-28 Bristol Myers Squibb Co Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof
CN107073109B (en) 2014-06-11 2021-08-06 凯西·A·格林 Use of VISTA agonists and antagonists to inhibit or enhance humoral immunity
TWI695011B (en) 2014-06-18 2020-06-01 美商梅爾莎納醫療公司 Monoclonal antibodies against her2 epitope and methods of use thereof
TWI831106B (en) 2014-06-20 2024-02-01 日商中外製藥股份有限公司 Pharmaceutical compositions for the prevention and/or treatment of diseases that develop and/or progress due to reduced or deficient activity of coagulation factor VIII and/or activated coagulation factor VIII
EP3161001A2 (en) 2014-06-25 2017-05-03 Novartis AG Antibodies specific for il-17a fused to hyaluronan binding peptide tags
WO2015198243A2 (en) 2014-06-25 2015-12-30 Novartis Ag Compositions and methods for long acting proteins
WO2015198240A2 (en) 2014-06-25 2015-12-30 Novartis Ag Compositions and methods for long acting proteins
WO2016007414A1 (en) 2014-07-08 2016-01-14 New York University Tau imaging ligands and their uses in the diagnosis and treatment of tauopathy
AU2015286569B2 (en) 2014-07-11 2021-04-15 Genmab A/S Antibodies binding AXL
UY36245A (en) 2014-07-31 2016-01-29 Amgen Res Munich Gmbh ANTIBODY CONSTRUCTS FOR CDH19 AND CD3
WO2016016415A1 (en) 2014-07-31 2016-02-04 Amgen Research (Munich) Gmbh Bispecific single chain antibody construct with enhanced tissue distribution
CA2956471A1 (en) 2014-07-31 2016-02-04 Amgen Research (Munich) Gmbh Optimized cross-species specific bispecific single chain antibody constructs
ES2726645T3 (en) 2014-08-01 2019-10-08 Inst Nat Sante Rech Med An anti-CD45RC antibody to use as a medicine
WO2016020880A2 (en) 2014-08-07 2016-02-11 Novartis Ag Angiopoietin-like 4 antibodies and methods of use
WO2016020882A2 (en) 2014-08-07 2016-02-11 Novartis Ag Angiopoetin-like 4 (angptl4) antibodies and methods of use
JP6858559B2 (en) 2014-08-20 2021-04-14 中外製薬株式会社 Method for measuring viscosity of protein solution
SG10201902924RA (en) 2014-10-03 2019-05-30 Massachusetts Inst Technology Antibodies that bind ebola glycoprotein and uses thereof
WO2016059220A1 (en) 2014-10-16 2016-04-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Tcr-activating agents for use in the treatment of t-all
US10738078B2 (en) 2014-11-03 2020-08-11 Bristol-Myers Squibb Company Use of caprylic acid precipitation for protein purification
BR112017009297B1 (en) 2014-11-05 2024-02-15 Annexon, Inc HUMANIZED C1Q COMPLEMENT ANTIFATOR ANTIBODIES, PHARMACEUTICAL COMPOSITION AND KIT COMPRISING THE SAME, THERAPEUTIC USE THEREOF, ISOLATED POLYNUCLEOTIDE, ISOLATED HOST CELL, AS WELL AS IN VITRO METHODS FOR DETECTING SYNAPSES
SG11201703574VA (en) 2014-11-07 2017-05-30 Eleven Biotherapeutics Inc Improved il-6 antibodies
WO2016073894A1 (en) 2014-11-07 2016-05-12 Eleven Biotherapeutics, Inc. Therapeutic agents with increased ocular retention
NZ731633A (en) 2014-11-21 2022-01-28 Bristol Myers Squibb Co Antibodies against cd73 and uses thereof
WO2016090347A1 (en) 2014-12-05 2016-06-09 Immunext, Inc. Identification of vsig8 as the putative vista receptor and its use thereof to produce vista/vsig8 modulators
UY36449A (en) 2014-12-19 2016-07-29 Novartis Ag COMPOSITIONS AND METHODS FOR ANTIBODIES DIRECTED TO BMP6
EP3945096A1 (en) 2014-12-19 2022-02-02 Regenesance B.V. Antibodies that bind human c6 and uses thereof
SG10202006538TA (en) 2014-12-23 2020-08-28 Bristol Myers Squibb Co Antibodies to tigit
TWI805046B (en) 2015-02-27 2023-06-11 日商中外製藥股份有限公司 Use of IL-6 receptor antibody for preparing pharmaceutical composition
JP6807859B2 (en) 2015-03-13 2021-01-06 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Use of alkaline cleaning to remove impurities in chromatography
EP3271403A1 (en) * 2015-03-19 2018-01-24 Regeneron Pharmaceuticals, Inc. Non-human animals that select for light chain variable regions that bind antigen
US20180105554A1 (en) 2015-03-20 2018-04-19 Bristol-Myers Squibb Company Use of dextran sulfate to enhance protein a affinity chromatography
US20180105555A1 (en) 2015-03-20 2018-04-19 Bristol-Myers Squibb Company Use of dextran for protein purification
EP4276116A3 (en) 2015-04-17 2024-01-17 Amgen Research (Munich) GmbH Bispecific antibody constructs for cdh3 and cd3
CA2978038A1 (en) 2015-04-17 2016-10-20 F. Hoffmann-La Roche Ag Combination therapy with coagulation factors and multispecific antibodies
CR20200517A (en) 2015-04-28 2021-01-12 Mitsubishi Tanabe Pharma Corp RGMa BINDING PROTEIN AND USE THEREOF
PE20180926A1 (en) 2015-05-29 2018-06-08 Bristol Myers Squibb Co ANTIBODIES AGAINST MEMBER 4 OF THE TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY (OX40) AND ITS USES
BR112017021484A2 (en) 2015-06-05 2018-07-03 Novartis Ag antibodies targeting bone morphogenetic protein 9 (bmp9) and methods for them
BR112017027870A2 (en) 2015-06-24 2018-08-28 Janssen Pharmaceutica Nv antibodies and anti-sight fragments
JP2018526977A (en) 2015-06-29 2018-09-20 ザ ロックフェラー ユニヴァーシティ Antibody against CD40 with enhanced agonist activity
EP3319993B1 (en) 2015-07-10 2020-01-15 Genmab A/S Axl-specific antibody-drug conjugates for cancer treatment
JO3711B1 (en) 2015-07-13 2021-01-31 H Lundbeck As Antibodies specific for hyperphosphorylated tau and methods of use thereof
GB201512215D0 (en) 2015-07-13 2015-08-19 Lundbeck & Co As H Agents,uses and methods
GB201512203D0 (en) 2015-07-13 2015-08-19 Lundbeck & Co As H Agents,uses and methods
TWI717375B (en) 2015-07-31 2021-02-01 德商安美基研究（慕尼黑）公司 Antibody constructs for cd70 and cd3
TWI829617B (en) 2015-07-31 2024-01-21 德商安美基研究（慕尼黑）公司 Antibody constructs for flt3 and cd3
TWI796283B (en) 2015-07-31 2023-03-21 德商安美基研究（慕尼黑）公司 Antibody constructs for msln and cd3
TWI744242B (en) 2015-07-31 2021-11-01 德商安美基研究（慕尼黑）公司 Antibody constructs for egfrviii and cd3
TW202346349A (en) 2015-07-31 2023-12-01 德商安美基研究（慕尼黑）公司 Antibody constructs for dll3 and cd3
CN108350072B (en) 2015-08-03 2022-05-24 诺华股份有限公司 Methods of treating FGF 21-associated disorders
JP6913078B2 (en) 2015-08-13 2021-08-04 ニューヨーク・ユニバーシティ Antibody-based molecules specific for the shortened Asp421 epitope of tau, and their use in the diagnosis and treatment of tau dysfunction.
US10358503B2 (en) 2015-08-13 2019-07-23 New York University Antibody-based molecules selective for the {P}Ser404 epitope of Tau and their uses in the diagnosis and treatment of tauopathy
AU2016320748B2 (en) 2015-09-09 2019-05-02 Novartis Ag Thymic stromal lymphopoietin (TSLP)-binding antibodies and methods of using the antibodies
EP3347377B1 (en) 2015-09-09 2021-02-17 Novartis AG Thymic stromal lymphopoietin (tslp)-binding antibodies and methods of using the antibodies
WO2017086367A1 (en) 2015-11-18 2017-05-26 中外製薬株式会社 Combination therapy using t cell redirection antigen binding molecule against cell having immunosuppressing function
EP3378488A4 (en) 2015-11-18 2019-10-30 Chugai Seiyaku Kabushiki Kaisha Method for enhancing humoral immune response
WO2017087678A2 (en) 2015-11-19 2017-05-26 Bristol-Myers Squibb Company Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof
PT3383920T (en) 2015-11-30 2024-04-15 Univ California Tumor-specific payload delivery and immune activation using a human antibody targeting a highly specific tumor cell surface antigen
EP3383903A1 (en) 2015-11-30 2018-10-10 Bristol-Myers Squibb Company Anti human ip-10 antibodies and their uses
EP3384030A4 (en) 2015-12-03 2019-07-03 Trianni, Inc. Enhanced immunoglobulin diversity
UY37030A (en) 2015-12-18 2017-07-31 Novartis Ag ANTIBODIES DIRECTED TO CD32B AND METHODS OF USE OF THE SAME
JP6954842B2 (en) 2015-12-25 2021-10-27 中外製薬株式会社 Antibodies with enhanced activity and methods for modifying them
EP3851457A1 (en) 2016-01-21 2021-07-21 Novartis AG Multispecific molecules targeting cll-1
PL3411404T3 (en) 2016-02-03 2023-02-13 Amgen Research (Munich) Gmbh Psma and cd3 bispecific t cell engaging antibody constructs
EA039859B1 (en) 2016-02-03 2022-03-21 Эмджен Рисерч (Мюник) Гмбх Bispecific antibody constructs binding egfrviii and cd3
US10301391B2 (en) 2016-02-03 2019-05-28 Amgen Research (Munich) Gmbh BCMA and CD3 bispecific T cell engaging antibody constructs
WO2017136734A1 (en) 2016-02-04 2017-08-10 Trianni, Inc. Enhanced production of immunoglobulins
BR112018016461A2 (en) 2016-02-12 2019-10-01 Janssen Pharmaceutica Nv antibodies and anti-sight fragments, their uses and their identification methods
MX2018010672A (en) 2016-03-04 2019-05-27 Univ Rockefeller Antibodies to cd40 with enhanced agonist activity.
EA201891983A8 (en) 2016-03-04 2020-05-28 Бристол-Майерс Сквибб Компани COMBINED THERAPY BY ANTIBODIES TO CD73
CA3016424A1 (en) 2016-03-14 2017-09-21 Chugai Seiyaku Kabushiki Kaisha Cell injury inducing therapeutic drug for use in cancer therapy
WO2017157305A1 (en) 2016-03-15 2017-09-21 Generon (Shanghai) Corporation Ltd. Multispecific fab fusion proteins and use thereof
KR102413037B1 (en) 2016-03-15 2022-06-23 메르사나 테라퓨틱스, 인코포레이티드 NAPI2B Targeted Antibody-Drug Conjugates and Methods of Using Same
JP2019509322A (en) 2016-03-22 2019-04-04 バイオノミクス リミテッド Administration of anti-LGR5 monoclonal antibody
US10765724B2 (en) 2016-03-29 2020-09-08 Janssen Biotech, Inc. Method of treating psoriasis with increased interval dosing of anti-IL12/23 antibody
WO2017175058A1 (en) 2016-04-07 2017-10-12 Janssen Pharmaceutica Nv Anti-vista antibodies and fragments, uses thereof, and methods of identifying same
MX2018012469A (en) 2016-04-15 2019-07-04 Immunext Inc Anti-human vista antibodies and use thereof.
EA201892362A1 (en) 2016-04-18 2019-04-30 Селлдекс Терапьютикс, Инк. AGONISTIC ANTIBODIES THAT ARE BINDING HUMAN CD40, AND THEIR OPTIONS
JOP20170091B1 (en) 2016-04-19 2021-08-17 Amgen Res Munich Gmbh Administration of a bispecific construct binding to CD33 and CD3 for use in a method for the treatment of myeloid leukemia
SG11201809793UA (en) 2016-05-09 2018-12-28 Bristol Myers Squibb Co Tl1a antibodies and uses thereof
KR102492057B1 (en) 2016-06-15 2023-01-26 노파르티스 아게 Methods of treating diseases using inhibitors of bone morphogenetic protein 6 (BMP6)
GEP20217222B (en) 2016-07-12 2021-02-10 Lundbeck A/S H Antibodies specific for hyperphosphorylated tau and methods of use thereof
SG11201900026TA (en) 2016-07-14 2019-01-30 Bristol Myers Squibb Co Antibodies against tim3 and uses thereof
WO2018029586A1 (en) 2016-08-07 2018-02-15 Novartis Ag Mrna-mediated immunization methods
US10947268B2 (en) 2016-08-12 2021-03-16 Bristol-Myers Squibb Company Methods of purifying proteins
WO2018044970A1 (en) 2016-08-31 2018-03-08 University Of Rochester Human monoclonal antibodies to human endogenous retrovirus k envelope (herv-k) and uses thereof
MX2019002510A (en) 2016-09-06 2019-06-24 Chugai Pharmaceutical Co Ltd Methods of using a bispecific antibody that recognizes coagulation factor ix and/or activated coagulation factor ix and coagulation factor x and/or activated coagulation factor x.
TW201825674A (en) 2016-09-09 2018-07-16 美商艾斯合顧問有限公司 Oncolytic virus expressing bispecific engager molecules
AU2017336799B2 (en) 2016-09-30 2023-08-31 Janssen Biotech, Inc. Safe and effective method of treating psoriasis with anti-IL23 specific antibody
CU20210030A7 (en) 2016-10-13 2021-11-04 Massachusetts Inst Technology ANTIBODIES THAT BIND THE ZIKA VIRUS ENVELOPE PROTEIN
US11339209B2 (en) 2016-11-14 2022-05-24 Novartis Ag Compositions, methods, and therapeutic uses related to fusogenic protein minion
RU2019114679A (en) 2016-11-15 2020-12-17 Х. Лундбекк А/С MEANS, WAYS OF APPLICATION AND METHODS OF TREATMENT OF SYNUCLEOPATHY
MX2019005661A (en) 2016-11-16 2019-10-07 Janssen Biotech Inc Method of treating psoriasis with anti-il-23 specific antibody.
TWI776827B (en) 2016-11-28 2022-09-11 日商中外製藥股份有限公司 Ligand-binding molecules capable of modulating ligand-binding activity
MA47019A (en) 2016-12-16 2021-04-21 H Lundbeck As AGENTS, USES AND METHODS
US10364286B2 (en) 2016-12-22 2019-07-30 H. Lundbeck A/S Monoclonal anti-alpha-synuclein antibodies for preventing tau aggregation
JP7062669B2 (en) 2016-12-23 2022-05-06 ブリストル－マイヤーズ スクイブ カンパニー Design of therapeutic immunoglobulin G4 for improved bioanalytic and bioprocessing properties
MA47205A (en) 2017-01-04 2019-11-13 H Lundbeck As SPECIFIC ANTIBODIES OF HYPERPHOSPHORYLATED TAU PROTEIN TO TREAT EYE DISEASES
WO2018129451A2 (en) 2017-01-09 2018-07-12 Merrimack Pharmaceuticals, Inc. Anti-fgfr antibodies and methods of use
EP3573658A4 (en) 2017-01-30 2021-07-21 Janssen Biotech, Inc. Anti-tnf antibodies, compositions, and methods for the treatment of active psoriatic arthritis
JOP20190189A1 (en) 2017-02-02 2019-08-01 Amgen Res Munich Gmbh Low ph pharmaceutical composition comprising t cell engaging antibody constructs
JP2020506947A (en) 2017-02-07 2020-03-05 ヤンセン バイオテツク，インコーポレーテツド Anti-TNF antibodies, compositions and methods for treating active ankylosing spondylitis
AU2018218557B9 (en) 2017-02-08 2021-06-24 Novartis Ag FGF21 mimetic antibodies and uses thereof
JP7136790B2 (en) 2017-02-17 2022-09-13 ブリストル－マイヤーズ スクイブ カンパニー Antibodies against alpha-synuclein and uses thereof
KR102628323B1 (en) 2017-03-24 2024-01-22 노바르티스 아게 How to prevent and treat heart disease
JP7050333B2 (en) 2017-03-24 2022-04-08 全薬工業株式会社 Anti-IgM / B cell surface antigen bispecific antibody
KR102660861B1 (en) 2017-03-30 2024-04-25 더 존스 홉킨스 유니버시티 Supramolecular high-affinity protein-binding system for purification of biomacromolecules
CN110461358A (en) 2017-03-31 2019-11-15 公立大学法人奈良县立医科大学 It can be used for preventing and/or treating the pharmaceutical composition of the polyspecific antigen binding molecules of the abnormal function comprising replacing platelet cofactor Ⅰ of factor IX
TWI788340B (en) 2017-04-07 2023-01-01 美商必治妥美雅史谷比公司 Anti-icos agonist antibodies and uses thereof
US20200109390A1 (en) 2017-04-27 2020-04-09 Chugai Seiyaku Kabushiki Kaisha Coagulation factor ix with improved pharmacokinetics
US11851486B2 (en) 2017-05-02 2023-12-26 National Center Of Neurology And Psychiatry Method for predicting and evaluating therapeutic effect in diseases related to IL-6 and neutrophils
MA48763A (en) 2017-05-05 2020-04-08 Amgen Inc PHARMACEUTICAL COMPOSITION INCLUDING BISPECIFIC ANTIBODY CONSTRUCTIONS FOR IMPROVED STORAGE AND ADMINISTRATION
WO2018229715A1 (en) 2017-06-16 2018-12-20 Novartis Ag Compositions comprising anti-cd32b antibodies and methods of use thereof
AU2018292579A1 (en) 2017-06-28 2019-12-05 Novartis Ag Methods for preventing and treating urinary incontinence
US10894833B2 (en) 2017-07-20 2021-01-19 H. Lundbeck A/S Agents, uses and methods for treatment
JP7379323B2 (en) 2017-08-18 2023-11-14 ザ・ジョンズ・ホプキンス・ユニバーシティ Supramolecular filament assembly for protein purification
TW201922780A (en) 2017-09-25 2019-06-16 美商健生生物科技公司 Safe and effective method of treating Lupus with anti-IL12/IL23 antibody
KR20200074160A (en) 2017-10-20 2020-06-24 가꼬우호우징 효고 이카다이가쿠 Pharmaceutical composition for inhibiting post-surgical adhesion containing anti-IL-6 receptor antibody
WO2019081983A1 (en) 2017-10-25 2019-05-02 Novartis Ag Antibodies targeting cd32b and methods of use thereof
AU2018376309A1 (en) 2017-11-28 2020-06-25 Chugai Seiyaku Kabushiki Kaisha Ligand-binding molecule having adjustable ligand-binding activity
EA202091422A1 (en) 2017-12-11 2020-08-28 Эмджен Инк. METHOD FOR CONTINUOUS PRODUCTION OF PRODUCTS BASED ON BISPECIFIC ANTIBODIES
EP3498293A1 (en) 2017-12-15 2019-06-19 Institut National De La Sante Et De La Recherche Medicale (Inserm) Treatment of monogenic diseases with an anti-cd45rc antibody
JP7314146B2 (en) 2017-12-28 2023-07-25 中外製薬株式会社 Cytotoxicity-inducing therapeutic agent
TW201940518A (en) 2017-12-29 2019-10-16 美商安進公司 Bispecific antibody construct directed to MUC17 and CD3
SG11202005323SA (en) 2018-01-12 2020-07-29 Bristol Myers Squibb Co Combination therapy with anti-il-8 antibodies and anti-pd-1 antibodies for treating cancer
CN111886255A (en) 2018-01-12 2020-11-03 百时美施贵宝公司 anti-TIM 3 antibodies and uses thereof
WO2019151418A1 (en) 2018-01-31 2019-08-08 元一 加藤 Therapeutic agent for asthma containing il-6 inhibitor
WO2019171252A1 (en) 2018-03-05 2019-09-12 Janssen Biotech, Inc. Methods of treating crohn's disease with anti-il23 specific antibody
TW202003565A (en) 2018-03-23 2020-01-16 美商必治妥美雅史谷比公司 Antibodies against MICA and/or MICB and uses thereof
EP3774882A1 (en) 2018-03-29 2021-02-17 Bristol-Myers Squibb Company Methods of purifying monomeric monoclonal antibodies
BR112020022265A2 (en) 2018-05-07 2021-02-23 Genmab A/S method for treating cancer in an individual, and, kit.
KR20210044183A (en) 2018-05-07 2021-04-22 젠맵 에이/에스 Methods of treating cancer using a combination of anti-PD-1 antibody and anti-tissue factor antibody-drug conjugate
JP2021523138A (en) 2018-05-11 2021-09-02 ヤンセン バイオテツク，インコーポレーテツド How to treat depression with IL-23 antibody
US20210196568A1 (en) 2018-05-21 2021-07-01 Chugai Seiyaku Kabushiki Kaisha Lyophilized formulation sealed in glass container
TW202015726A (en) 2018-05-30 2020-05-01 瑞士商諾華公司 Entpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies
CN112533635A (en) 2018-07-10 2021-03-19 田边三菱制药株式会社 Method for preventing or treating pain in peripheral neuropathy or diseases accompanied by peripheral neuropathy or astrocytosis
JP2021530697A (en) 2018-07-18 2021-11-11 ヤンセン バイオテツク，インコーポレーテツド Sustained response predictor after treatment with anti-IL23 specific antibody
CN112771075A (en) 2018-07-30 2021-05-07 安进研发（慕尼黑）股份有限公司 Prolonged administration of bispecific antibody constructs that bind to CD33 and CD3
PE20211400A1 (en) 2018-08-03 2021-07-27 Amgen Res Munich Gmbh ANTIBODY CONSTRUCTS FOR CLDN18.2 AND CD3
WO2020043670A1 (en) 2018-08-27 2020-03-05 Affimed Gmbh Cryopreserved nk cells preloaded with an antibody construct
JP2022502076A (en) 2018-09-18 2022-01-11 メリマック ファーマシューティカルズ インコーポレーティッド Anti-TNFR2 antibody and its use
CA3113837C (en) 2018-09-24 2022-07-12 Janssen Biotech, Inc. Safe and effective method of treating ulcerative colitis with anti-il12/il23 antibody
MX2021003976A (en) 2018-10-11 2021-05-27 Amgen Inc Downstream processing of bispecific antibody constructs.
UY38407A (en) 2018-10-15 2020-05-29 Novartis Ag TREM2 STABILIZING ANTIBODIES
UA127902C2 (en) 2018-10-30 2024-02-07 Генмаб А/С Methods of treating cancer with a combination of an anti-vegf antibody and an anti-tissue factor antibody-drug conjugate
US11274150B2 (en) 2018-11-16 2022-03-15 Bristol-Myers Squibb Company Anti-human natural killer cell inhibitory receptor group 2A protein (NKG2A) antibodies
EP3883607A4 (en) 2018-11-20 2022-08-17 Janssen Biotech, Inc. Safe and effective method of treating psoriasis with anti-il-23 specific antibody
MA54562A (en) 2018-12-18 2021-10-27 Janssen Biotech Inc SAFE AND EFFECTIVE METHOD OF TREATING LUPUS WITH AN ANTI-IL12/IL23 ANTIBODY
WO2020148651A1 (en) 2019-01-15 2020-07-23 Janssen Biotech, Inc. Anti-tnf antibody compositions and methods for the treatment of juvenile idiopathic arthritis
SG11202107951YA (en) 2019-01-22 2021-08-30 Bristol Myers Squibb Co Antibodies against il-7r alpha subunit and uses thereof
US20220064278A1 (en) 2019-01-23 2022-03-03 Janssen Biotech, Inc. Anti-TNF Antibody Compositions for Use in Methods for the Treatment of Psoriatic Arthritis
EP3915581A4 (en) 2019-01-24 2023-03-22 Chugai Seiyaku Kabushiki Kaisha Novel cancer antigens and antibodies of said antigens
US20220290128A1 (en) 2019-02-04 2022-09-15 National University Corporation Ehime University CAR LIBRARY AND scFv MANUFACTURING METHOD
EP3932952A4 (en) 2019-02-28 2022-11-30 Juntendo Educational Foundation Antibody capable of binding to truncated mutant calreticulin, and diagnostic, prophylactic or therapeutic drug for myeloproliferative neoplasms
US20220281990A1 (en) 2019-03-01 2022-09-08 Merrimack Pharmaceuticals, Inc. Anti-tnfr2 antibodies and uses thereof
MA55282A (en) 2019-03-14 2022-01-19 Janssen Biotech Inc MANUFACTURING METHODS FOR THE PRODUCTION OF ANTI-TNF ANTIBODY COMPOSITIONS
EP3938391A1 (en) 2019-03-14 2022-01-19 Janssen Biotech, Inc. Methods for producing anti-tnf antibody compositions
EA202192508A1 (en) 2019-03-14 2022-03-29 Янссен Байотек, Инк. METHODS FOR OBTAINING COMPOSITIONS OF ANTIBODIES TO TNF
KR20210141990A (en) 2019-03-14 2021-11-23 얀센 바이오테크 인코포레이티드 Methods of Preparation for Generating Anti-IL12/IL23 Antibody Compositions
MA55383A (en) 2019-03-18 2022-01-26 Janssen Biotech Inc METHOD OF TREATING PSORIASIS IN PEDIATRIC SUBJECTS WITH AN ANTI-IL12/IL23 ANTIBODY
EP3943108A4 (en) 2019-03-19 2023-01-04 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule containing antigen-binding domain of which binding activity to antigen is changed depending on mta, and library for obtaining said antigen-binding domain
KR20210144819A (en) 2019-03-29 2021-11-30 브리스톨-마이어스 스큅 컴퍼니 Methods for Determining Hydrophobicity of Chromatographic Resins
SG11202110986YA (en) 2019-04-10 2021-11-29 Chugai Pharmaceutical Co Ltd Method for purifying fc region-modified antibody
JP7501876B2 (en) 2019-04-17 2024-06-18 国立大学法人広島大学 Treatment for urological cancer characterized by administering an IL-6 inhibitor and a CCR2 inhibitor in combination
CN113874073A (en) 2019-05-23 2021-12-31 詹森生物科技公司 Methods of treating inflammatory bowel disease with combination therapy of antibodies to IL-23 and TNF α
EP3976648A1 (en) 2019-06-03 2022-04-06 Janssen Biotech, Inc. Anti-tnf antibody compositions, and methods for the treatment of psoriatic arthritis
JP2022535534A (en) 2019-06-03 2022-08-09 ヤンセン バイオテツク，インコーポレーテツド Anti-TNF Antibodies, Compositions and Methods for Treating Active Ankylosing Spondylitis
AU2020288499A1 (en) 2019-06-05 2022-01-27 Chugai Seiyaku Kabushiki Kaisha Antibody cleavage site-binding molecule
KR20220019785A (en) 2019-06-12 2022-02-17 노파르티스 아게 Natriuretic Peptide Receptor 1 Antibodies and Methods of Use
CA3137494A1 (en) 2019-06-13 2020-12-17 Amgen Inc. Automated biomass-based perfusion control in the manufacturing of biologics
JP2022542890A (en) 2019-07-26 2022-10-07 アムジエン・インコーポレーテツド Anti-IL13 antigen binding protein
WO2021028752A1 (en) 2019-08-15 2021-02-18 Janssen Biotech, Inc. Anti-tfn antibodies for treating type i diabetes
JP2022547135A (en) 2019-09-10 2022-11-10 アムジエン・インコーポレーテツド Method for Purifying Bispecific Antigen-Binding Polypeptides with Enhanced Protein L Capture Dynamic Binding Capacity
TW202124446A (en) 2019-09-18 2021-07-01 瑞士商諾華公司 Combination therapies with entpd2 antibodies
CN114502590A (en) 2019-09-18 2022-05-13 诺华股份有限公司 ENTPD2 antibodies, combination therapies, and methods of using these antibodies and combination therapies
WO2021091815A1 (en) 2019-11-04 2021-05-14 Seagen Inc. Anti-cd30 antibody-drug conjugates and their use for the treatment of hiv infection
MX2022005222A (en) 2019-11-07 2022-06-08 Genmab As Methods of treating cancer with a combination of an anti-pd-1 antibody and an anti-tissue factor antibody-drug conjugate.
TW202131954A (en) 2019-11-07 2021-09-01 丹麥商珍美寶股份有限公司 Methods of treating cancer with a combination of a platinum-based agent and an anti-tissue factor antibody-drug conjugate
US20220396599A1 (en) 2019-11-13 2022-12-15 Amgen Inc. Method for Reduced Aggregate Formation in Downstream Processing of Bispecific Antigen-Binding Molecules
JP2023509373A (en) 2019-12-20 2023-03-08 ノヴァロック バイオセラピューティクス， リミテッド ANTI-INTERLEUKIN-23 P19 ANTIBODY AND METHODS OF USE THEREOF
UY38995A (en) 2019-12-20 2021-06-30 Amgen Inc MESOTHELIN TARGETING CD40 AGONIST MULTI-SPECIFIC ANTIBODY CONSTRUCTS FOR THE TREATMENT OF SOLID TUMORS
AR120898A1 (en) 2019-12-26 2022-03-30 Univ Osaka AGENT TO TREAT OR PREVENT ACUTE NEUROMYELITIS OPTICA
AU2020414409A1 (en) 2019-12-27 2022-06-16 Affimed Gmbh Method for the production of bispecific FcyRIIl x CD30 antibody construct
US20230090965A1 (en) 2020-01-15 2023-03-23 Osaka University Prophylactic or therapeutic agent for dementia
EP4091632A1 (en) 2020-01-15 2022-11-23 Osaka University Agent for prevention or treatment of diabetic autonomic neuropathy
WO2021150824A1 (en) 2020-01-22 2021-07-29 Amgen Research (Munich) Gmbh Combinations of antibody constructs and inhibitors of cytokine release syndrome and uses thereof
TW202200615A (en) 2020-03-12 2022-01-01 美商安進公司 Method for treatment and prophylaxis of crs in patients
KR20220155338A (en) 2020-03-19 2022-11-22 암젠 인크 Antibodies to mucin 17 and uses thereof
EP4129333A4 (en) 2020-03-27 2024-06-12 PhotoQ3 Inc. Pharmaceutical drug for destroying tumor cells
CN115379858A (en) 2020-04-06 2022-11-22 光爱科技公司 Medicinal product for killing tumor cells
JP2023106635A (en) 2020-04-17 2023-08-02 中外製薬株式会社 Bispecific antigen binding molecules and compositions related thereto, uses, kits and methods for producing compositions
JP2023523760A (en) 2020-05-01 2023-06-07 ノバルティス アーゲー immunoglobulin variant
JP2023523794A (en) 2020-05-01 2023-06-07 ノバルティス アーゲー engineered immunoglobulin
US20230192867A1 (en) 2020-05-15 2023-06-22 Bristol-Myers Squibb Company Antibodies to garp
CA3183756A1 (en) 2020-05-19 2021-11-25 Amgen Inc. Mageb2 binding constructs
WO2021235537A1 (en) 2020-05-22 2021-11-25 中外製薬株式会社 Antibody for neutralizing substance having coagulation factor viii (f.viii) function-substituting activity
EP4157874A2 (en) 2020-05-29 2023-04-05 Amgen Inc. Adverse effects-mitigating administration of a bispecific antibody construct binding to cd33 and cd3
EP4174071A1 (en) 2020-06-24 2023-05-03 The University of Tokyo Photosensitizing dye
TW202216210A (en) 2020-06-29 2022-05-01 丹麥商珍美寶股份有限公司 Anti-tissue factor antibody-drug conjugates and their use in the treatment of cancer
WO2022014703A1 (en) 2020-07-17 2022-01-20 田辺三菱製薬株式会社 Agent for preventing or treating muscular disease
WO2022025030A1 (en) 2020-07-28 2022-02-03 中外製薬株式会社 Prefilled syringe preparation with needle, provided with needle shield and including novel modified antibody
AU2021317974A1 (en) 2020-07-31 2023-03-16 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical Composition comprising Cell Expressing Chimeric Receptor
JP2023534765A (en) 2020-08-07 2023-08-10 フォーティス セラピューティクス，インク． CD46 targeting immune complexes and methods of use thereof
IL300764A (en) 2020-08-27 2023-04-01 Juntendo Educational Found Anti-cleaved mutant calr-cd3 bispecific antibody and pharmaceutical composition
JP2023540526A (en) 2020-09-04 2023-09-25 ノヴァロック バイオセラピューティクス， リミテッド Nectin-4 antibody and its use
WO2022074206A1 (en) 2020-10-08 2022-04-14 Affimed Gmbh Trispecific binders
WO2022096716A2 (en) 2020-11-06 2022-05-12 Amgen Inc. Multitargeting bispecific antigen-binding molecules of increased selectivity
JP2023547499A (en) 2020-11-06 2023-11-10 ノバルティス アーゲー Antibody Fc variant
KR20230098335A (en) 2020-11-06 2023-07-03 암젠 인크 Antigen binding domains with reduced clipping ratio
US20230406929A1 (en) 2020-11-06 2023-12-21 Amgen Inc. Polypeptide constructs binding to cd3
AU2021374036A1 (en) 2020-11-06 2023-06-08 Amgen Inc. Polypeptide constructs selectively binding to cldn6 and cd3
WO2022108931A2 (en) 2020-11-17 2022-05-27 Seagen Inc. Methods of treating cancer with a combination of tucatinib and an anti-pd-1/anti-pd-l1 antibody
EP4259661A1 (en) 2020-12-14 2023-10-18 Novartis AG Reversal binding agents for anti-natriuretic peptide receptor 1 (npr1) antibodies and uses thereof
AR124914A1 (en) 2021-02-18 2023-05-17 Mitsubishi Tanabe Pharma Corp NEW ANTI-PAD4 ANTIBODY
JP2024510588A (en) 2021-03-12 2024-03-08 ヤンセン バイオテツク，インコーポレーテツド Method of treating psoriatic arthritis patients with inadequate response to TNF therapy with anti-IL23-specific antibodies
WO2022191306A1 (en) 2021-03-12 2022-09-15 中外製薬株式会社 Pharmaceutical composition for treatment or prevention of myasthenia gravis
CA3212729A1 (en) 2021-03-12 2022-09-15 Janssen Biotech, Inc. Safe and effective method of treating psoriatic arthritis with anti-il23 specific antibody
AU2022246675A1 (en) 2021-04-02 2023-10-19 Amgen Inc. Mageb2 binding constructs
IL307672A (en) 2021-05-06 2023-12-01 Amgen Res Munich Gmbh Cd20 and cd22 targeting antigen-binding molecules for use in proliferative diseases
EP4367137A1 (en) 2021-07-09 2024-05-15 Janssen Biotech, Inc. Manufacturing methods for producing anti-tnf antibody compositions
IL309987A (en) 2021-07-09 2024-03-01 Janssen Biotech Inc Manufacturing methods for producing anti-il12/il23 antibody compositions
KR20240034218A (en) 2021-07-09 2024-03-13 얀센 바이오테크 인코포레이티드 Manufacturing Methods for Producing Anti-TNF Antibody Compositions
AU2022320948A1 (en) 2021-07-30 2024-01-18 Affimed Gmbh Duplexbodies
CN117999098A (en) 2021-09-24 2024-05-07 光爱科技公司 Pharmaceutical products for killing tumor cells
WO2023057871A1 (en) 2021-10-04 2023-04-13 Novartis Ag Surfactant stabilizers
KR20240082388A (en) 2021-10-08 2024-06-10 추가이 세이야쿠 가부시키가이샤 Method for preparing prefilled syringe formulations
IL312401A (en) 2021-10-29 2024-06-01 Janssen Biotech Inc Methods of treating crohn's disease with anti-il23 specific antibody
IL312110A (en) 2021-10-29 2024-06-01 Seagen Inc Methods of treating cancer with a combination of an anti-pd-1 antibody and an anti-cd30 antibody-drug conjugate
CA3233696A1 (en) 2021-11-03 2023-05-11 Joachim Koch Bispecific cd16a binders
WO2023079493A1 (en) 2021-11-03 2023-05-11 Affimed Gmbh Bispecific cd16a binders
CA3238377A1 (en) 2021-11-15 2023-05-19 Janssen Biotech, Inc. Methods of treating crohn's disease with anti-il23 specific antibody
CA3239216A1 (en) 2021-11-23 2023-06-01 Janssen Biotech, Inc. Method of treating ulcerative colitis with anti-il23 specific antibody
US20230312703A1 (en) 2022-03-30 2023-10-05 Janssen Biotech, Inc. Method of Treating Psoriasis with IL-23 Specific Antibody
TW202400658A (en) 2022-04-26 2024-01-01 瑞士商諾華公司 Multispecific antibodies targeting il-13 and il-18
TW202408583A (en) 2022-05-06 2024-03-01 丹麥商珍美寶股份有限公司 Methods of treating cancer with anti-tissue factor antibody-drug conjugates
TW202346368A (en) 2022-05-12 2023-12-01 德商安美基研究（慕尼黑）公司 Multichain multitargeting bispecific antigen-binding molecules of increased selectivity
WO2023223265A1 (en) 2022-05-18 2023-11-23 Janssen Biotech, Inc. Method for evaluating and treating psoriatic arthritis with il23 antibody
WO2024013724A1 (en) 2022-07-15 2024-01-18 Pheon Therapeutics Ltd Antibody-drug conjugates
WO2024059675A2 (en) 2022-09-14 2024-03-21 Amgen Inc. Bispecific molecule stabilizing composition
US20240199734A1 (en) 2022-11-22 2024-06-20 Janssen Biotech, Inc. Method of Treating Ulcerative Colitis with Anti-IL23 Specific Antibody
WO2024127366A1 (en) 2022-12-16 2024-06-20 Pheon Therapeutics Ltd Antibodies to cub domain-containing protein 1 (cdcp1) and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990004036A1 (en) * 1988-10-12 1990-04-19 Medical Research Council Production of antibodies from transgenic animals
WO1992003918A1 (en) * 1990-08-29 1992-03-19 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
WO1993012227A1 (en) * 1991-12-17 1993-06-24 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991000906A1 (en) * 1989-07-12 1991-01-24 Genetics Institute, Inc. Chimeric and transgenic animals capable of producing human antibodies
AU633698B2 (en) * 1990-01-12 1993-02-04 Amgen Fremont Inc. Generation of xenogeneic antibodies

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990004036A1 (en) * 1988-10-12 1990-04-19 Medical Research Council Production of antibodies from transgenic animals
WO1992003918A1 (en) * 1990-08-29 1992-03-19 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
WO1993012227A1 (en) * 1991-12-17 1993-06-24 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
DURDIK ET AL: "Isotype switching by a microinjected mu immunoglobulin heavy chain gene in transgenic mice", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,NATIONAL ACADEMY OF SCIENCE. WASHINGTON,US, vol. 86, April 1989 (1989-04-01), pages 2346 - 2350, XP002100492, ISSN: 0027-8424 *
KITAMURA ET AL: "A B cell-deficient mouse by targeted disruption of the membrane exon of the immununoglobulin chain gene", NATURE,GB,MACMILLAN JOURNALS LTD. LONDON, vol. 350, 4 April 1991 (1991-04-04), pages 423 - 426, XP002065596, ISSN: 0028-0836 *
LONBERG NILS ET AL: "A transgenic mouse that expresses a diversity of human sequence heavy and light chain immunoglobulins.", JOURNAL OF CELLULAR BIOCHEMISTRY SUPPLEMENT, no. 17 PART B, 1993, Keystone Symposium on Molecular Aspects of B Lymphocyte Differentiation;Taos, New Mexico, USA; February 1-8, 1993, pages 204, XP000944314, ISSN: 0733-1959 *
LONBERG NILS ET AL: "Antigen-specific human antibodies from mice comprising four distinct genetic modifications.", NATURE (LONDON), vol. 368, no. 6474, 28 April 1994 (1994-04-28), pages 856 - 859, XP000941636, ISSN: 0028-0836 *
LONBERG NILS ET AL: "Human sequence antibodies from transgenic mice.", JOURNAL OF CELLULAR BIOCHEMISTRY SUPPLEMENT, no. 18D, 1994, Keystone Symposium on Antibody Engineering: Research and Application of Genes Encoding Immunoglobulins;Lake Tahoe, California, USA; March 7-13, 1994, pages 185, XP000944312, ISSN: 0733-1959 *
See also references of WO9425585A1 *
TAYLOR L D ET AL: "A TRANSGENIC MOUSE THAT EXPRESSES A DIVERSITY OF HUMAN SEQUENCE HEAVY AND LIGHT CHAIN IMMUNOGLOBINS", NUCLEIC ACIDS RESEARCH,GB,OXFORD UNIVERSITY PRESS, SURREY, vol. 20, no. 23, 11 December 1992 (1992-12-11), pages 6287 - 6295, XP002041128, ISSN: 0305-1048 *
TAYLOR LISA D ET AL: "Human immunoglobulin transgenes undergo rearrangement, somatic mutation and class switching in mice that lack endogenous IgM.", INTERNATIONAL IMMUNOLOGY, vol. 6, no. 4, April 1994 (1994-04-01), pages 579 - 591, XP000944310, ISSN: 0953-8178 *
TUAILLON NADINE ET AL: "Human immunoglobulin heavy-chain minilocus recombination in transgenic mice: Gene-segment use in mu and gamma transcripts.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 90, no. 8, 1993, 1993, pages 3720 - 3724, XP000941639, ISSN: 0027-8424 *

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