AR106920A1 - Péptidos y combinaciones de péptidos para el uso en la inmunoterapia contra la leucemia linfocítica crónica (llc) y otros tipos de cáncer - Google Patents

Péptidos y combinaciones de péptidos para el uso en la inmunoterapia contra la leucemia linfocítica crónica (llc) y otros tipos de cáncer

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Publication number
AR106920A1
AR106920A1 ARP160103738A ARP160103738A AR106920A1 AR 106920 A1 AR106920 A1 AR 106920A1 AR P160103738 A ARP160103738 A AR P160103738A AR P160103738 A ARP160103738 A AR P160103738A AR 106920 A1 AR106920 A1 AR 106920A1
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Argentina
Prior art keywords
peptide
seq
lymphocytes
peptides
antigen
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Application number
ARP160103738A
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English (en)
Inventor
Wiebe Anita
Signh Harpreet
fritsche Jens
Schoor Oliver
Weinschenk Toni
Mahr Andrea
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Immatics Biotechnologies Gmbh
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Application filed by Immatics Biotechnologies Gmbh filed Critical Immatics Biotechnologies Gmbh
Publication of AR106920A1 publication Critical patent/AR106920A1/es

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    • A61K39/46—Cellular immunotherapy
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    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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Abstract

Reivindicación 1: Péptido que comprende una secuencia de aminoácidos seleccionada entre el grupo consistente en la SEQ ID Nº 1 a la SEQ ID Nº 385, y secuencias variantes de las mismas que son como mínimo homólogas en un 88% a las SEQ ID Nº 1 a la SEQ ID Nº 385, y en que dicha variante se une a una o varias moléculas del complejo mayor de histocompatibilidad (MHC) y/o induce la reacción cruzada de linfocitos T con dicho péptido variante; y una sal farmacéuticamente aceptable del mismo, en que dicho péptido no es un polipéptido entero. Reivindicación 12: Método in vitro para producir linfocitos T activados, método que comprende la puesta en contacto de linfocitos T in vitro con antígeno cargado en moléculas MHC de clase I o II humanas que se expresan en la superficie de una célula presentadora de antígeno adecuada o en un constructo artificial que emula a una célula presentadora de antígeno durante un período de tiempo suficiente para activar dichos linfocitos T de un modo específico de antígeno, siendo dicho antígeno un péptido acorde con la cualquiera de las reivindicaciones 1 a 4. Reivindicación 16: Uso de un péptido acorde con cualquiera de las reivindicaciones 1 a 6, del ácido nucleico acorde con la reivindicación 7, del vector de expresión acorde con la reivindicación 8, de la célula acorde con la reivindicación 9, del linfocito T activado acorde con la reivindicación 13 o del anticuerpo acorde con la reivindicación 15 destinado al uso en el diagnóstico y/o el tratamiento del cáncer o a al uso en la fabricación de un medicamento contra el cáncer. Reivindicación 21: Método para producir una vacuna personalizada contra el cáncer, o un tratamiento a base de un compuesto y/o de células para un paciente individual, en que dicho método comprende: a) identificación de los péptidos asociados a tumor (TUMAP) presentes en una muestra tumoral de dicho paciente en cuestión; b) comparación de los péptidos identificados en a) con un archivo de péptidos que han sido preseleccionados por su inmunogenicidad y/o su sobrepresentación en tumores en comparación con los tejidos normales; c) selección de al menos un péptido del archivo que coincida con el TUMAP identificado en el paciente; y d) fabricación y/o formulación de la vacuna personalizada o del tratamiento a base de un compuesto o de células basadas en el paso c). Reivindicación 34: Ácido nucleico, que codifica un TCR acorde con cualquiera de las reivindicaciones 30 a 33, opcionalmente ligado a una secuencia promotora heteróloga. Reivindicación 38: Composición farmacéutica que comprende como mínimo un principio activo seleccionado del grupo consistente en a) el péptido seleccionado del grupo consistente en las SEQ ID Nº 1 a SEQ ID Nº 385; b) receptor de linfocito T reactivo con un péptido y/o un complejo péptido-MHC acorde con a); c) proteína de fusión que comprende un péptido acorde con a), y los aminoácidos N-terminales 1 a 80 de la cadena invariable asociada a antígeno HLA-DR (li); d) ácido nucleico que codifica cualquiera de a) a c) o un vector de expresión que comprende dicho ácido nucleico; e) célula hospedadora que comprende el vector de expresión de d); f) linfocito T activado, obtenido con un método que comprende la puesta en contacto en condiciones in vitro de linfocitos T con un péptido acorde con a) expresado en la superficie de una célula presentadora de antígeno adecuada durante el período de tiempo suficiente para activar dicho linfocito T de un modo específico de antígeno, así como un método para transferir esos linfocitos T activados al paciente autólogo o a otros pacientes; g) anticuerpo, o receptor de linfocito T soluble, reactivo a un péptido y/o al complejo péptido-MHC acorde con a) y/o una célula que presenta un péptido acorde con a), y potencialmente modificado por fusión con, por ejemplo, dominios inmunoactivadores o toxinas; h) aptámero que reconoce un péptido seleccionado del grupo consistente en las SEQ ID Nº 1 a SEQ ID Nº 385 y/o un complejo de un péptido seleccionado del grupo consistente en las SEQ ID Nº 1 a SEQ ID Nº 385 con una molécula MHC; i) péptido o soporte conjugado o marcado acorde con cualquiera de a) a h) y un vehículo farmacéuticamente aceptable y, opcionalmente, excipientes y/o estabilizantes farmacéuticamente aceptables.
ARP160103738A 2015-12-10 2016-12-06 Péptidos y combinaciones de péptidos para el uso en la inmunoterapia contra la leucemia linfocítica crónica (llc) y otros tipos de cáncer AR106920A1 (es)

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GBGB1521746.6A GB201521746D0 (en) 2015-12-10 2015-12-10 Novel peptides and combination of peptides for use in immunotherapy against CLL and other cancers

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AR106920A1 true AR106920A1 (es) 2018-02-28

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