AR110857A1 - Péptidos y combinaciones de péptidos para el uso en la inmunoterapia contra el cáncer de ovario y otros tipos de cáncer - Google Patents
Péptidos y combinaciones de péptidos para el uso en la inmunoterapia contra el cáncer de ovario y otros tipos de cáncerInfo
- Publication number
- AR110857A1 AR110857A1 ARP180100192A ARP180100192A AR110857A1 AR 110857 A1 AR110857 A1 AR 110857A1 AR P180100192 A ARP180100192 A AR P180100192A AR P180100192 A ARP180100192 A AR P180100192A AR 110857 A1 AR110857 A1 AR 110857A1
- Authority
- AR
- Argentina
- Prior art keywords
- cancer
- peptide
- variant
- seq
- cell
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 17
- 206010028980 Neoplasm Diseases 0.000 title abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 6
- 201000011510 cancer Diseases 0.000 title abstract 3
- 206010033128 Ovarian cancer Diseases 0.000 title abstract 2
- 206010061535 Ovarian neoplasm Diseases 0.000 title abstract 2
- 238000009169 immunotherapy Methods 0.000 title 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 5
- 108700018351 Major Histocompatibility Complex Proteins 0.000 abstract 4
- 239000012634 fragment Substances 0.000 abstract 4
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 abstract 4
- 239000000427 antigen Substances 0.000 abstract 3
- 108091007433 antigens Proteins 0.000 abstract 3
- 102000036639 antigens Human genes 0.000 abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 3
- 108091008874 T cell receptors Proteins 0.000 abstract 2
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- 210000000612 antigen-presenting cell Anatomy 0.000 abstract 2
- 238000002659 cell therapy Methods 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000000338 in vitro Methods 0.000 abstract 2
- 239000003446 ligand Substances 0.000 abstract 2
- 239000012528 membrane Substances 0.000 abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 abstract 1
- 108091023037 Aptamer Proteins 0.000 abstract 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 abstract 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 206010009944 Colon cancer Diseases 0.000 abstract 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 abstract 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 abstract 1
- 208000022072 Gallbladder Neoplasms Diseases 0.000 abstract 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 abstract 1
- 102000043129 MHC class I family Human genes 0.000 abstract 1
- 108091054437 MHC class I family Proteins 0.000 abstract 1
- 206010027406 Mesothelioma Diseases 0.000 abstract 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 abstract 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 abstract 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 abstract 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 abstract 1
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 208000006265 Renal cell carcinoma Diseases 0.000 abstract 1
- 206010041067 Small cell lung cancer Diseases 0.000 abstract 1
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 abstract 1
- 208000005718 Stomach Neoplasms Diseases 0.000 abstract 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 abstract 1
- 208000002495 Uterine Neoplasms Diseases 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- -1 and optionally Substances 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 208000006990 cholangiocarcinoma Diseases 0.000 abstract 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 abstract 1
- 201000010989 colorectal carcinoma Diseases 0.000 abstract 1
- 230000037029 cross reaction Effects 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 201000004101 esophageal cancer Diseases 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 201000010175 gallbladder cancer Diseases 0.000 abstract 1
- 206010017758 gastric cancer Diseases 0.000 abstract 1
- 208000005017 glioblastoma Diseases 0.000 abstract 1
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 abstract 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 abstract 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 abstract 1
- 230000005847 immunogenicity Effects 0.000 abstract 1
- 201000005202 lung cancer Diseases 0.000 abstract 1
- 208000020816 lung neoplasm Diseases 0.000 abstract 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 230000002018 overexpression Effects 0.000 abstract 1
- 201000002528 pancreatic cancer Diseases 0.000 abstract 1
- 208000008443 pancreatic carcinoma Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000000587 small cell lung carcinoma Diseases 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
- 201000011549 stomach cancer Diseases 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
- 201000005112 urinary bladder cancer Diseases 0.000 abstract 1
- 206010046766 uterine cancer Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464499—Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/892—Reproductive system [uterus, ovaries, cervix, testes]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Wood Science & Technology (AREA)
- Pathology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Medical Informatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
Abstract
Reivindicación 1: Péptido que comprende una secuencia de aminoácidos seleccionada entre el grupo consistente en la SEQ ID Nº 1 a la SEQ ID Nº 772, y secuencias variantes de las mismas que son como mínimo homólogas en un 88% a las SEQ ID Nº 1 a la SEQ ID Nº 772, y en que dicha variante se une a una o varias moléculas del complejo mayor de histocompatibilidad (MHC) y/o induce la reacción cruzada de linfocitos T con dicho péptido variante; y una sal farmacéuticamente aceptable del mismo, en que dicho péptido no es un polipéptido entero. Reivindicación 7: Anticuerpo, en particular un anticuerpo soluble o unido a membrana, preferiblemente un anticuerpo monoclonal o fragmento del mismo, que reconoce específicamente el péptido o variante del mismo acorde con cualquiera de las reivindicaciones 1 a 5, preferiblemente el péptido o variante del mismo acorde con cualquiera de las reivindicaciones 1 a 5 cuando está unido a una molécula de MHC. Reivindicación 8: Receptor de linfocito T, preferiblemente soluble o unido a membrana, o un fragmento del mismo, que reacciona ante un ligando de HLA, en que dicho ligando es el péptido o variante del mismo acorde con cualquiera de las reivindicaciones 1 a 5, preferiblemente el péptido o variante del mismo acorde con cualquiera de las reivindicaciones 1 a 5 cuando está unido a una molécula de MHC. Reivindicación 14: Método in vitro para producir linfocitos T activados, el cual comprende la puesta en contacto en condiciones in vitro de linfocitos T con moléculas de MHC de clase I o Il humanas cargadas con antígeno y expresadas en la superficie de una célula presentadora de antígeno adecuada o de un constructo artificial que imite a una célula presentadora de antígeno durante un período de tiempo suficiente para activar dichos linfocitos T de una forma específica de antígeno, siendo dicho antígeno un péptido acorde con cualquiera de las reivindicaciones 1 a 4. Reivindicación 16: Composición farmacéutica que comprende al menos un ingrediente activo seleccionado del grupo consistente en el péptido acorde con cualquiera de las reivindicaciones 1 a 6, el anticuerpo o fragmento del mismo acorde con la reivindicación 7, el receptor de linfocito T o fragmento del mismo acorde con la reivindicación 8 ó 9, el aptámero acorde con la reivindicación 11, el ácido nucleico o el vector de expresión acordes con la reivindicación 12, la célula hospedadora acorde con la reivindicación 13, el linfocito T activado acorde con la reivindicación 15, o un ingrediente activo marcado o conjugado, y un vehiculo farmacéuticamente aceptable, y opcionalmente, excipientes y/o estabilizantes farmacéuticamente aceptables. Reivindicación 21: El uso acorde con la reivindicación 20, en que dicho cáncer es seleccionado entre el grupo formado por cáncer de ovario, carcinoma hepatocelular, carcinoma colorrectal, glioblastoma, cáncer gástrico, cáncer de esófago, cáncer de pulmón amicrocítico, cáncer de pulmón microcítico, cáncer de páncreas, carcinoma de células renales, cáncer de próstata, melanoma, cáncer de mama, leucemia linfocítica crónica, linfoma no hodgkiniano, leucemia mieloide aguda, cáncer de vesícula biliar y colangiocarcinoma, cáncer de vejiga urinaria, cáncer de útero, carcinoma epidermoide de cabeza y cuello, mesotelioma y otros tumores que presenten la sobreexpresión de una proteína de la cual derive un péptido de las SEQ ID Nº 1 a SEQ ID Nº 772. Reivindicación 24: Método para producir una vacuna o una terapia celular o basada en un compuesto contra el cáncer que sean personalizadas para un paciente concreto, en que dicho método comprende: a) identificación de los péptidos asociados a tumor (TUMAP) presentes en una muestra tumoral de dicho paciente en cuestión; b) comparación de los péptidos identificados en a) con un archivo de péptidos que han sido preseleccionados por su inmunogenicidad y/o su sobrepresentación en tumores en comparación con los tejidos normales; c) selección de al menos un péptido del archivo que coincida con el TUMAP identificado en el paciente; y d) fabricación y/o formulación de la vacuna o la terapia celular o basada en un compuesto que sean personalizadas basadas en el paso c).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762451255P | 2017-01-27 | 2017-01-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR110857A1 true AR110857A1 (es) | 2019-05-08 |
Family
ID=63039109
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP180100192A AR110857A1 (es) | 2017-01-27 | 2018-01-26 | Péptidos y combinaciones de péptidos para el uso en la inmunoterapia contra el cáncer de ovario y otros tipos de cáncer |
Country Status (3)
| Country | Link |
|---|---|
| US (8) | US10738100B2 (es) |
| AR (1) | AR110857A1 (es) |
| EA (1) | EA201991444A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR110857A1 (es) * | 2017-01-27 | 2019-05-08 | Immatics Biotechnologies Gmbh | Péptidos y combinaciones de péptidos para el uso en la inmunoterapia contra el cáncer de ovario y otros tipos de cáncer |
| RS64217B1 (sr) * | 2017-01-27 | 2023-06-30 | Immatics Biotechnologies Gmbh | Novi peptidi i kombinacija peptida za upotrebu u imunoterapiji protiv raka jajnika i drugih malignih tumora |
| WO2018209270A1 (en) | 2017-05-11 | 2018-11-15 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (snas) |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7285631B2 (en) | 2001-08-10 | 2007-10-23 | Serono Genetics Institute S.A. | Human cDNAs and proteins and uses thereof |
| WO2005017102A2 (en) | 2003-05-30 | 2005-02-24 | Diadexus, Inc. | Compositions, splice variants and methods relating to ovarian specific nucleic acids and proteins |
| EP1691824B1 (en) | 2003-11-19 | 2009-03-11 | Survac ApS | Proteins belonging to the bcl-2 family and fragments thereof, and their use in cancer patients |
| EP1806359B1 (en) | 2005-09-05 | 2010-03-17 | Immatics Biotechnologies GmbH | Tumor-associated peptides binding promiscuously to human leukocyte antigen (HLA) class II molecules |
| EP2565204B1 (en) | 2007-07-27 | 2015-10-07 | immatics biotechnologies GmbH | Novel immunogenic epitopes for immunotherapy |
| AU2009253539B2 (en) | 2008-04-17 | 2014-03-20 | Io Biotech Aps | Indoleamine 2, 3-dioxygenase based immunotherapy |
| PL2113253T3 (pl) | 2008-04-30 | 2010-09-30 | Immatics Biotechnologies Gmbh | Nowa postać leku - preparat zawierający peptydy nowotworowe wiążące się z antygenami ludzkich leukocytów klasy I i II, zastosowany w szczepionce |
| ES2532896T5 (es) | 2008-05-14 | 2018-03-20 | Immatics Biotechnologies Gmbh | Péptidos del MHC de clase II novedosos y potentes derivados de survivina y neurocan |
| WO2010037397A1 (en) | 2008-10-01 | 2010-04-08 | Dako Denmark A/S | Mhc multimers in cmv immune monitoring |
| WO2010037395A2 (en) | 2008-10-01 | 2010-04-08 | Dako Denmark A/S | Mhc multimers in cancer vaccines and immune monitoring |
| GB201006360D0 (en) | 2010-04-16 | 2010-06-02 | Immatics Biotechnologies Gmbh | Method for differentially quantifying naturally processed HLA-restricted peptides for cancer, autoimmune and infectious diseases immunotherapy development |
| WO2014009400A1 (en) | 2012-07-13 | 2014-01-16 | Telefonica, S.A. | A method and a system for generating context-based content recommendations to users |
| GB201319446D0 (en) | 2013-11-04 | 2013-12-18 | Immatics Biotechnologies Gmbh | Personalized immunotherapy against several neuronal and brain tumors |
| GB201512369D0 (en) | 2015-07-15 | 2015-08-19 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against epithelial ovarian cancer and other cancers |
| AR110857A1 (es) | 2017-01-27 | 2019-05-08 | Immatics Biotechnologies Gmbh | Péptidos y combinaciones de péptidos para el uso en la inmunoterapia contra el cáncer de ovario y otros tipos de cáncer |
| RS64217B1 (sr) * | 2017-01-27 | 2023-06-30 | Immatics Biotechnologies Gmbh | Novi peptidi i kombinacija peptida za upotrebu u imunoterapiji protiv raka jajnika i drugih malignih tumora |
| US11945850B2 (en) | 2018-09-17 | 2024-04-02 | Immatics Biotechnologies Gmbh | B*44 restricted peptides for use in immunotherapy against cancers and related methods |
-
2018
- 2018-01-26 AR ARP180100192A patent/AR110857A1/es unknown
- 2018-01-26 EA EA201991444A patent/EA201991444A1/ru unknown
- 2018-01-26 US US15/881,078 patent/US10738100B2/en active Active
-
2020
- 2020-03-11 US US16/815,965 patent/US10781244B2/en active Active
- 2020-06-24 US US16/911,109 patent/US10899820B2/en active Active
- 2020-08-20 US US16/998,162 patent/US11053296B2/en active Active
- 2020-12-10 US US17/117,191 patent/US20210101958A1/en not_active Abandoned
- 2020-12-10 US US17/117,188 patent/US11078253B2/en active Active
-
2021
- 2021-06-17 US US17/350,977 patent/US11840562B2/en active Active
- 2021-07-09 US US17/372,136 patent/US20210363221A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20200207832A1 (en) | 2020-07-02 |
| US10738100B2 (en) | 2020-08-11 |
| US20200317748A1 (en) | 2020-10-08 |
| US20210363221A1 (en) | 2021-11-25 |
| EA201991444A1 (ru) | 2019-12-30 |
| US20210009654A1 (en) | 2021-01-14 |
| US11078253B2 (en) | 2021-08-03 |
| US11053296B2 (en) | 2021-07-06 |
| US11840562B2 (en) | 2023-12-12 |
| US20210101958A1 (en) | 2021-04-08 |
| US10781244B2 (en) | 2020-09-22 |
| US20210101957A1 (en) | 2021-04-08 |
| US20210340217A1 (en) | 2021-11-04 |
| US20180222961A1 (en) | 2018-08-09 |
| US10899820B2 (en) | 2021-01-26 |
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| AR127118A2 (es) | Péptidos y combinación de péptidos novedosos para su uso en inmunoterapia contra diversos tumores | |
| JP6639233B2 (ja) | Ｍａｇｅ−ａ１を認識する高結合活性結合分子 | |
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| JP2019502360A5 (es) | ||
| JP2019516663A5 (es) | ||
| RU2020113032A (ru) | Новые пептиды и комбинации пептидов для применения в иммунотерапии рака легких, в том числе немелкоклеточного рака легких (нмрл) и других видов рака | |
| EA201892021A1 (ru) | Трансфицированные t-клетки и t-клеточные рецепторы для применения в иммунотерапии раковых заболеваний | |
| EA201891759A1 (ru) | Трансфицированные t-клетки и t-клеточные рецепторы для применения в иммунотерапии раковых заболеваний | |
| EA202190587A3 (ru) | Новые пептиды и комбинации пептидов для применения в иммунотерапии гепатоклеточной карциномы (гкк) и других видов рака | |
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| CR20220248A (es) | Células t transfectadas y receptores de células t de utilidad en inmunoterapias contra el cáncer | |
| JP2020516681A5 (es) | ||
| MD3319985T2 (ro) | Noi peptide și combinații de peptide pentru utilizare în imunoterapie împotriva cancerului esofagian și a altor cancere | |
| PH12018501892A1 (en) | Transfected t-cells and t-cell receptors for use in immunotherapy against cancers | |
| JP2019515653A5 (es) | ||
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| JP2019520038A5 (es) | ||
| JP2019536426A5 (es) | ||
| HRP20211580T1 (hr) | Novi peptidi i kombinacije peptida za upotrebu u imunoterpiji protiv hepatocelularnog karcinoma (hcc) i drugih rakova | |
| AR114737A1 (es) | Inmunoterapia con péptidos restringidos a a*01 y una combinación de péptidos contra el cáncer y métodos relacionados |