AR121383A2 - Péptidos y combinación de péptidos y andamiajes para su uso en inmunoterapia contra carcinoma de células renales (rcc) y otros cánceres - Google Patents

Péptidos y combinación de péptidos y andamiajes para su uso en inmunoterapia contra carcinoma de células renales (rcc) y otros cánceres

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Publication number
AR121383A2
AR121383A2 ARP210100439A ARP210100439A AR121383A2 AR 121383 A2 AR121383 A2 AR 121383A2 AR P210100439 A ARP210100439 A AR P210100439A AR P210100439 A ARP210100439 A AR P210100439A AR 121383 A2 AR121383 A2 AR 121383A2
Authority
AR
Argentina
Prior art keywords
peptide
cell
antigen
seq
peptides
Prior art date
Application number
ARP210100439A
Other languages
English (en)
Inventor
Jens Fritsche
Weinschenk Toni Dr
Singh Harpreet Dr
Mahr Andrea Dr
Schoor Oliver Dr
Colette Song
Original Assignee
Immatics Biotechnologies Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immatics Biotechnologies Gmbh filed Critical Immatics Biotechnologies Gmbh
Publication of AR121383A2 publication Critical patent/AR121383A2/es

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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Abstract

Reivindicación 1: Un péptido aislado caracterizado porque comprende una secuencia de aminoácidos sintética que consiste en la SEQ ID Nº 150; y una sal farmacéuticamente aceptable de las mismas, en donde dicho péptido no es un polipéptido de longitud completa. Reivindicación 11: Un método in vitro para producir linfocitos T activados, caracterizado porque el método comprende poner en contacto in vitro células T con moléculas MHC de clase I o II humanas cargadas con antígeno expresadas sobre la superficie de una célula presentadora de antígeno adecuada o una construcción artificial que imita una célula presentadora de antígeno durante un periodo de tiempo suficiente para activar a dichas células T de una forma específica de antígeno, en donde dicho antígeno es un péptido de acuerdo a cualquiera de las reivindicaciones 1 a 5. Reivindicación 14: Un anticuerpo, en particular un anticuerpo soluble o unido a membrana, caracterizado porque reconoce específicamente el péptido aislado de acuerdo a cualquiera de las reivindicaciones 1 a 4, preferiblemente el péptido aislado de acuerdo a cualquiera de las reivindicaciones 1 a 4 cuando está unido a una molécula MHC en donde el anticuerpo porta una función efectora adicional tal como un dominio o toxina de estimulación inmune. Reivindicación 18: Un conjunto de componentes caracterizado porque comprende: (a) un recipiente que comprende una composición farmacéutica que contiene el péptido aislado de acuerdo a cualquiera de las reivindicaciones 1 a 5, el ácido nucleico aislado de acuerdo a la reivindicación 6, el vector de expresión aislado de acuerdo a la reivindicación 7, la célula huésped de acuerdo a la reivindicación 8, el linfocito T activado de acuerdo a la reivindicación 12 o el anticuerpo de acuerdo a la reivindicación 14, en solución o en forma liofilizada; (b) opcionalmente, un segundo recipiente que contiene un diluyente o solución de reconstitución para la formulación liofilizada; (c) opcionalmente, por lo menos uno o más péptidos que se eligen del grupo que consiste en SEQ ID Nº 1 a SEQ ID Nº 151, y (d) opcionalmente, instrucciones para (i) el uso de la solución o (ii) la reconstitución y/o el uso de la formulación liofilizada. Reivindicación 21: Un método para producir una vacuna anticáncer personalizada, caracterizado porque dicho método comprende: a) identificar péptidos asociados a tumor (TUMAP) presentados por una muestra tumoral a partir de dicho paciente individual; b) comparar los péptidos identificados en a) con un depósito de péptidos que se han precribado para inmunogenicidad y/o sobrepresentación en tumores en comparación con tejidos normales c) seleccionar por lo menos un péptido a partir del depósito que coincide con un TUMAP identificado en el paciente; y d) formular la vacuna personalizada o terapia basada en compuesto o celular en base al paso c). Reivindicación 36: Una composición farmacéutica caracterizada porque comprende por lo menos un ingrediente activo que se elige del grupo que consiste en a) un péptido que consiste en la SEQ ID Nº 150; b) un receptor de células T reactivo con un péptido y/o el complejo de péptido y MHC de acuerdo a a); c) una proteína de fusión que comprende un péptido de acuerdo a a), y los aminoácidos N-terminales 1 a 80 de la cadena invariante (Ii) asociada a antígeno de HLADR; d) un ácido nucleico que codifica para cualquiera de a) a c) o un vector de expresión que comprende dicho ácido nucleico, e) una célula huésped que comprende el vector de expresión de d), f) un linfocito T activado, que se obtiene por un método que comprende poner en contacto en vitro células T con un péptido de acuerdo a a) expresado sobre la superficie de una célula presentadora de antígeno adecuada durante un periodo de tiempo suficiente para activar a dicha célula T en una forma específica de antígeno, así como también un método para transferir estas células T activadas en el paciente autólogo o en otros pacientes; g) un anticuerpo, o receptor de células T soluble, reactivo contra un péptido y/o el complejo de péptido y MHC de acuerdo a a) y/o una célula que presenta un péptido de acuerdo a a), y potencialmente modificado por fusión con por ejemplo, dominios o toxinas activadoras del sistema inmune, h) un aptámero que reconoce un péptido que consiste en la SEQ ID Nº 150 y/o un complejo de un péptido que consiste en la SEQ ID Nº 150 con una molécula de MHC, i) un péptido o esqueleto conjugado o marcado de acuerdo a cualquiera de a) a h) y un transportador farmacéuticamente aceptable, y opcionalmente, excipientes y/o estabilizantes farmacéuticamente aceptable.
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