HRP20201281T1 - Novi peptidi i kombinacija peptida za uporabu u imunoterapiji protiv epitelnog karcinoma jajnika i drugih karcinoma - Google Patents

Novi peptidi i kombinacija peptida za uporabu u imunoterapiji protiv epitelnog karcinoma jajnika i drugih karcinoma Download PDF

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HRP20201281T1
HRP20201281T1 HRP20201281TT HRP20201281T HRP20201281T1 HR P20201281 T1 HRP20201281 T1 HR P20201281T1 HR P20201281T T HRP20201281T T HR P20201281TT HR P20201281 T HRP20201281 T HR P20201281T HR P20201281 T1 HRP20201281 T1 HR P20201281T1
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peptide
cell
cancer
antibody
nucleic acid
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HRP20201281TT
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Heiko Schuster
Janet PEPER
Philipp Wagner
Hans-Georg Rammensee
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Immatics Biotechnologies Gmbh
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Claims (14)

1. Peptid koji se sastoji od slijeda aminokiselina sukladno SEQ ID br. 82.
2. Peptid prema zahtjevu 1, koji navodi kako peptid uključuje nepeptidne vezove.
3. Peptid prema zahtjevu 1 ili 2, pri čemu je navedeni peptid dio fuzijskog proteina, koji sadrži N-terminalne aminokiseline HLA-DR invarijantnog lanca vezanog za antigene (Ii).
4. T-stanični receptor, po mogućnosti rekombinantni, topljiv ili na membranu vezan T-stanični receptor, koji je reaktivan s HLA ligandom, pri čemu se navedeni ligand sastoji od aminokiselinskog slijeda SEQ ID br. 82.
5. Antitijelo, posebice topljivo ili na membranu vezano antitijelo, koje posebno prepoznaje peptide prema zahtjevu 1, po mogućnosti peptid prema bilo kojem od zahtjeva 1 kada se veže za MHC-molekule.
6. Nukleinska kiselina, koja kodira peptid prema bilo kojem od zahtjeva 1 ili 3 ili TCR prema zahtjevu 4 ili antitijelo prema zahtjevu 5, opcionalno vezano na heterologni promotorski slijed ili ekspresijski vektor koji sadrži navedenu nukleinsku kiselinu.
7. Rekombinantna stanica domaćin koja sadrži peptid prema zahtjevu 1 ili 3 ili nukleinsku kiselinu ili ekspresijski vektor prema zahtjevu 6, pri čemu navedena stanica domaćin po mogućnosti predstavlja antigen kao što je dendritička stanica ili gdje je navedena stanica domaćin po mogućnosti T-stanica ili NK stanica.
8. Metoda za proizvodnju peptida prema bilo kojem zahtjevu 1 ili 3 ili za proizvodnju T-staničnih receptora prema zahtjevu 4 ili antitijelo prema zahtjevu 5, metoda koja obuhvaća kultiviranje stanice domaćina prema zahtjevu 7, koja predstavlja peptide prema zahtjevu 1 ili ekspresivna nukleinska kiselina ili ekspresivni vektor prema zahtjevu 6 i izoliranje peptida ili TCR ili antitijelo od stanice domaćina ili njezinog medija za kultiviranje.
9. In vitro metoda za proizvodnju aktiviranih T-limfocita, metoda je koja obuhvaća kontaktiranje in vitro T-stanica humanim MHC molekulama klase I s umetnutim antigenima koje se eksprimiraju na površini odgovarajuće stanice koja prezentira antigen ili umjetnom konstrukcijom koja oponaša stanicu koja predstavlja antigen u vremenskom razdoblju dovoljnom da se aktiviraju navedene T-stanice na način svojstven antigenu, pri čemu je navedeni antigen peptid u skladu sa zahtjevom 1.
10. Aktivirani T-limfocit, proizveden metodom u skladu s patentnim zahtjevom 9 koji selektivno prepoznaje stanicu koja predstavlja polipeptid koji sadrži sekvenciju aminokiseline sukladno zahtjevu 1.
11. Farmaceutski sastav koji sadrži najmanje jedan aktivni sastojak, koji je odabran iz grupe koja se sastoje od peptida prema zahtjevu 1 ili 3, nukleinsku kiselinu ili ekspresivni vektor prema zahtjevu 6, stanicu prema zahtjevu 7, aktivirani T-limfocit prema zahtjevu 10 ili antitijelo prema zahtjevu 5 ili T-stanični receptor prema zahtjevu 4 i farmaceutski prihvatljivog nositelja i po potrebi farmaceutski prihvatljivog nositelja i/ili stabilizatora.
12. Peptid prema zahtjevu 1 ili 3, nukleinska kiselina ili ekspresivni vektor prema zahtjevu 6, stanica prema zahtjevu 7, aktivirani T-limfocit prema zahtjevu 10 ili antitijelo prema zahtjevu 5 ili T-stanični receptor prema zahtjevu 4 za upotrebu u medicini, po mogućnosti za upotrebu u dijagnostici i/ili za liječenje karcinoma.
13. Peptid prema zahtjevu 1 ili 3, nukleinska kiselina ili ekspresivni vektor prema zahtjevu 6, stanica prema zahtjevu 7, aktivirani T-limfocit prema zahtjevu 10 ili antitijelo prema zahtjevu 5 ili T-stanični receptor prema zahtjevu 4 za upotrebu u dijagnostici i/ili za liječenje karcinoma prema zahtjevu 12, pri čemu je karcinom karcinom jajnika, nemalostanični karcinom pluća, malostanični karcinom pluća, karcinom bubrega, karcinom mozga, karcinom debelog crijeva ili rektuma, karcinom želuca, karcinom jetre, karcinom pankreasa, karcinom prostate, leukemija, karcinom dojke, karcinom Merkelovih stanica, melanom, karcinom ezofalgusa, karcinom mjehura, karcinom uterusa, karcinom žučnog mjehura, karcinom žučnih vodova ili drugi karcinomi koji pokazuje prekomjernu ekspresiju proteina iz kojeg je izveden peptid prema SEQ ID br. 82, posebice karcinom jajnika.
14. Komplet koji sadrži: a) posudu koja sadrži farmaceutski sastav koji sadrži peptid prema zahtjevu 1 ili 3, nukleinsku kiselinu ili ekspresijski vektor prema zahtjevu 6, stanicu prema zahtjevu 7, aktivirani T-limfocit prema zahtjevu 10 ili antitijela prema zahtjevu 5 ili T-stanični receptor prema zahtjevu 4, u otopini ili u liofiliziranom obliku; b) drugu posudu koja sadrži diluens ili otopinu za rekonstituciju za liofiliziranu formulaciju; c) najmanje jedan dodatni peptid iz skupine koja se sastoji od SEQ ID br. 1 do 81 i 83 do 549 i d) po potrebi, upute za (i) uporabu otopine ili (ii) rekonstituciju i/ili uporabu liofilizirane formulacije i e) nadalje jedan dodatni (iii) međuspremnik, (iv) diluens, (v) filtar, (vi) igla ili (v) štrcaljka.
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