ME03808B - Novi peptidi i kombinacija peptida za upotrebu u imunoterapiji za epitelijalni karcinom jajnika i druge maligne tumore - Google Patents

Novi peptidi i kombinacija peptida za upotrebu u imunoterapiji za epitelijalni karcinom jajnika i druge maligne tumore

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Publication number
ME03808B
ME03808B MEP-2020-159A MEP2020159A ME03808B ME 03808 B ME03808 B ME 03808B ME P2020159 A MEP2020159 A ME P2020159A ME 03808 B ME03808 B ME 03808B
Authority
ME
Montenegro
Prior art keywords
cell
cancer
peptide
antibody
nucleic acid
Prior art date
Application number
MEP-2020-159A
Other languages
German (de)
English (en)
French (fr)
Inventor
Heiko Schuster
Janet Peper
Philipp Wagner
Hans-Georg Rammensee
Original Assignee
Immatics Biotechnologies Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immatics Biotechnologies Gmbh filed Critical Immatics Biotechnologies Gmbh
Publication of ME03808B publication Critical patent/ME03808B/me

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Claims (14)

1. Peptid koji sadrži aminokiselinsku sekvencu u skladu sa ID BR. SEKV 82.
2. Peptid u skladu sa patentnim zahtevom 1, naznačen time to navedeni peptid sadrži nepeptidne veze.
3. Peptid u skladu sa patentnim zahtevom 1 ili 2, naznačen time to je navedeni peptid deo fuzionog proteina, naročito koji sadrži N-terminalne aminokiseline HLA-DR antigen-asociranog nepromenljivog lanca (li).
4. T-ćelijski receptor, poželjno rekombinantni, solubilni ili vezan za membranu T-ćelijski receptor koji je reaktivan sa HLA ligandom, naznačeno time što navedeni ligand sadrži aminokiselinsku sekvencu ID BR. SEKV 82.
5. Antitelo, konkretno solubilno ili antitelo vezano za membranu, koje specificno prepoznaje peptid u skladu sa patentnim zahtevom 1, poželjno peptid u skladu sa bilo kojim od patentnog zahteva 1 kada je vezan za MHC molekul.
6. Nukleinska kiselina koja kodira za peptid u skladu sa bilo kojim od patentnih zahteva 1 ili 3 ili za TCR u skladu sa patentnim zahtevom 4, ili antitelo u skladu sa patentnim zahtevom 5, opciono povezana sa heterolognom promoterskom sekvencom, ili vektor ekspresije koji eksprimira navedenu nukleinsku kiselinu.
7. Rekombinantna ćelija domaćin koja sadrži peptid u skladu sa patentnim zahtevom 1 ili 3, ili nukleinsku kiselinu ili vektor ekspresije u skladu sa patentnim zahtevom 6, naznačena time što je navedena ćelija domaćin poželjno antigen-prezentujuća ćelija kao to je dendritična ćelija, ili naznačena time što je navedena ćelija domaćin poželjno T ćelija ili NK ćelija.
8. Metod za proizvodnju peptida u skladu sa bilo kojim od patentnih zahteva 1 ili 3, ili za proizvodnju T-ćelijskog receptora u skladu sa patentnim zahtevom 4, ili antitela u skladu sa patentnim zahtevom 5, pri čemu se metod sastoji od kultivisanja ćelije domaćina u skladu sa patentnim zahtevom 7 koja prezentuje peptid u skladu sa patentnim zahtevom 1, ili eksprimira nukleinsku kiselinu ili vektor ekspresije u skladu sa patentnim zahtevom 6, i izolovanja peptida ili TCR-a ili antitela iz ćelije domaćina ili njenog medijuma za kultivaciju.
9. In vitro metod za proizvodnju aktiviranih T limfocita, pri čemu se metod sastoji od dovodenja u kontakt in vitro T ćelija sa humanim MHC molekulima klase i sa ubačenim antigenom eksprimiranim na površini prikladne antigen-prezentujuće ćelije ili veštačkog konstrukta koji imitira antigen-prezentujuću ćeliju u toku vremenskog perioda koji je dovoljan da se navedene T ćelije aktiviraju na antigen-specifičan način, naznačeno time što je navedeni antigen peptid u skladu sa patentnim zahtevom 1.
10. Aktivirani T limfocit, proizveden pomoću metoda u skladu sa patentnim zahtevom 9, koji selektivno prepoznaje ćeliju koja prezentuje polipeptid koji sadrzi aminokiselinsku sekvencu navedenu u patentnom zahtevu 1.
11. Farmaceutska smeša koja sadrži najmanje jedan aktivan sastojak izabran iz grupe koju čine peptid u skladu sa patentnim zahtevom 1 ili 3, nukleinska kiselina ili vektor ekspresije u skladu sa patentnim zahtevom 6, ćelija u skladu sa patentnim zahtevom 7, aktivirani T limfocit u skladu sa patentnim zahtevom 10 ili antitelo u skladu sa patentnim zahtevom 5 ili T-ćelijski receptor u skladu sa patentnim zahtevom 4, i farmaceutski prihvatljiv nosač, i opciono, dodatne farmaceutski prihvatljive pomoćne materije i/ili stabilizatore.
12. Peptid u skladu sa patentnim zahtevom 1 ili 3, nukleinska kiselina ili vektor ekspresije u skladu sa patentnim zahtevom 6, ćelija u skladu sa patentnim zahtevom 7, aktivirani T limfocit u skladu sa patentnim zahtevom 10 ili antitelo u skladu sa patentnim zahtevom 5 ili T-ćelijski receptor u skladu sa patentnim zahtevom 4 za upotrebu u medicini, poželjno za upotrebu u dijagnostikovanju i/ili lečenju raka.
13. Peptid u skladu sa patentnim zahtevom 1 ili 3, nukleinska kiselina ili vektor ekspresije u skladu sa patentnim zahtevom 6, ćelija u skladu sa patentnim zahtevom 7, aktivirani T limfocit u skladu sa patentnim zahtevom 10 ili antitelo u skladu sa patentnim zahtevom 5 ili T-ćelijski receptor u skladu sa patentnim zahtevom 4 za upotrebu u dijagnostikovanju i/ili lečenju raka u skladu sa patentnim zahtevom 12, naznačenog time sto je navedeni rak izabran iz grupe koju čine rak jajnika, nesitnoćelijski karcinom pluća, sitnoćelijski karcinom pluća, rak bubrega, rak mozga, rak kolona ili rektuma, rak želuca, rak jetre, rak pankreasa, rak prostate, leukemija, rak dojke, karcinom Merkelovih ćelija, melanom, rak jednjaka, rak mokraćne bešike, rak materice, rak žučne kese, rak žučnih puteva i drugi tumori koji pokazuju prekomernu ekspresiju proteina iz kojeg je dobijen peptid u skladu sa ID BR. SEKV 82, konkretno rak jajnika.
14. Komplet koji se sastoji od:a) posude koja sadrti farmaceutsku smešu koja sadrži peptid u skladu sa patentnim zahtevom 1 ili 3, nukleinsku kiselinu ili vektor ekspresije u skladu sa patentnim zahtevom 6, ćeliju u skladu sa patentnim zahtevom 7, aktivirani T limfocit u skladu sa patentnim zahtevom 10 ili antitelo u skladu sa patentnim zahtevom 5 ili T-celijski receptor u skladu sa patentnim zahtevom 4, u rastvoru ili u liofiliziranom obliku;b) opciono, druge posude koja sadrži razblaživač ili rastvor za rekonstituciju za liofiliziranu formulaciju;c) opciono, najmanje još jednog peptida odabranog iz grupe koja se sastoji od ID BR. SEKV 1 do 81 i 83 do 549, id) opciono, uputstva za (i) upotrebu rastvora ili (ii) rekonstituciju i/ili upotrebu liofilizirane formulacije, ie) opciono dalje sadrži jedan ili više od navedenih (iii) pufer, (iv) razblaživač (v) filter, (vi) igla ili (v) brizgalica.
MEP-2020-159A 2015-07-15 2016-07-14 Novi peptidi i kombinacija peptida za upotrebu u imunoterapiji za epitelijalni karcinom jajnika i druge maligne tumore ME03808B (me)

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