HRP20210709T1 - Peptidi i kombinacija peptida za imunoterapiju protiv karcinoma prostate i druge vrste karcinoma - Google Patents
Peptidi i kombinacija peptida za imunoterapiju protiv karcinoma prostate i druge vrste karcinoma Download PDFInfo
- Publication number
- HRP20210709T1 HRP20210709T1 HRP20210709TT HRP20210709T HRP20210709T1 HR P20210709 T1 HRP20210709 T1 HR P20210709T1 HR P20210709T T HRP20210709T T HR P20210709TT HR P20210709 T HRP20210709 T HR P20210709T HR P20210709 T1 HRP20210709 T1 HR P20210709T1
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- Prior art keywords
- cell
- peptide
- cancer
- fusion protein
- nucleic acid
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- 108090000765 processed proteins & peptides Proteins 0.000 title claims 23
- 102000004196 processed proteins & peptides Human genes 0.000 title claims 7
- 206010028980 Neoplasm Diseases 0.000 title claims 4
- 206010060862 Prostate cancer Diseases 0.000 title claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 title claims 2
- 238000009169 immunotherapy Methods 0.000 title 1
- 210000004027 cell Anatomy 0.000 claims 11
- 108020001507 fusion proteins Proteins 0.000 claims 10
- 102000037865 fusion proteins Human genes 0.000 claims 10
- 210000001744 T-lymphocyte Anatomy 0.000 claims 9
- 108091008874 T cell receptors Proteins 0.000 claims 8
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 239000013604 expression vector Substances 0.000 claims 7
- 239000000427 antigen Substances 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 201000009030 Carcinoma Diseases 0.000 claims 3
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- 201000011510 cancer Diseases 0.000 claims 3
- 230000014509 gene expression Effects 0.000 claims 3
- 239000003446 ligand Substances 0.000 claims 3
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 229940041181 antineoplastic drug Drugs 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 239000012931 lyophilized formulation Substances 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000017897 Carcinoma of esophagus Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 1
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 102000043129 MHC class I family Human genes 0.000 claims 1
- 108091054437 MHC class I family Proteins 0.000 claims 1
- 208000002030 Merkel cell carcinoma Diseases 0.000 claims 1
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 1
- 210000000013 bile duct Anatomy 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 208000017763 cutaneous neuroendocrine carcinoma Diseases 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 201000007487 gallbladder carcinoma Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 108010028930 invariant chain Proteins 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 230000002018 overexpression Effects 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 208000010570 urinary bladder carcinoma Diseases 0.000 claims 1
- 210000004291 uterus Anatomy 0.000 claims 1
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- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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Claims (14)
1. Peptid koji uključuje slijed aminokiselina SEQ ID br. 4; ili njegovu farmaceutski prihvatljivu sol.
2. Peptid prema zahtjevu 1, koji navodi kako peptid uključuje nepeptidne vezove.
3. Fuzijski protein koji sadrži peptid prema zahtjevu 1 ili 2 i N-terminalne aminokiseline invarijantnog lanca vezanog za antigene HLA-DR (Ii).
4. T-stanični receptor, po mogućnosti rekombinantni, topljiv ili na membranu vezan T-stanični receptor, koji je reaktivan s HLA ligandom, pri čemu navedeni ligand ima najmanje 88 % identičnosti prema aminokiselinskoj sekvenci u skladu s to SEQ ID br. 4, i po mogućnosti se sastoji od aminokiselinskog slijeda SEQ ID br. 4., gdje je po potrebi navedeni ligand dio peptida MHC-kompleksa.
5. Antitijelo, posebice topljivo ili na membranu vezano antitijelo, koje posebno prepoznaje peptide prema bilo kojem od zahtjeva 1 ili 2 ili fuzijski protein prema zahtjevu 3, po mogućnosti peptide prema zahtjevu 1 kada se veže za MHC-molekule.
6. Nukleinska kiselina, koja kodira peptid prema zahtjevu 1 ili TCR prema zahtjevu 4 ili antitijelo prema zahtjevu 5, opcionalno vezano na heterologni promotorski slijed ili ekspresijski vektor koji sadrži navedenu nukleinsku kiselinu.
7. Rekombinantna stanica domaćin koja sadrži peptid prema zahtjevu 1 ili fuzijski protein prema zahtjevu 3 ili nukleinsku kiselinu ili ekspresijski vektor prema zahtjevu 6, pri čemu navedena stanica domaćin po mogućnosti predstavlja antigen kao što je dendritička stanica za ekspresiju peptidnog ili fuzijskog proteina, ili gdje je navedena stanica domaćin po mogućnosti T-stanica ili NK stanica za ekspresiju antitijela T-staničnog receptora.
8. Metoda za proizvodnju peptida prema zahtjevu 1 ili fuzijski protein prema zahtjevu 3 ili za proizvodnju T-staničnih receptora prema zahtjevu 4 ili antitijelo prema zahtjevu 5, metoda koja se sastoji od kultiviranja stanice domaćina prema zahtjevu 7 koja predstavlja peptide prema zahtjevu 1 ili fuzijski protein prema zahtjevu 3 ili ekspresivna nukleinska kiselina ili ekspresivni vektor prema zahtjevu 6 i izoliranje peptida ili fuzijski protein ili TCR ili antitijelo od stanice domaćina ili njezinog medija za kultiviranje.
9. In vitro metoda za proizvodnju aktiviranih T-limfocita, metoda je koja obuhvaća kontaktiranje in vitro T-stanica humanim MHC molekulama klase I s umetnutim antigenima koje se eksprimiraju na površini odgovarajuće stanice koja prezentira antigen u vremenskom razdoblju dovoljnom da se aktiviraju navedene T-stanice na način svojstven antigenu, pri čemu je navedeni antigen peptid u skladu sa zahtjevom 1.
10. Aktivirani T-limfocit, proizveden metodom u skladu s patentnim zahtjevom 9 koji selektivno prepoznaje stanicu koja predstavlja polipeptid koji sadrži sekvenciju amino kiseline sukladno zahtjevu 1.
11. Farmaceutski sastav koji uključuje najmanje jedan aktivni sastojak, koji je odabran iz grupe peptida prema bilo kojem od zahtjeva 1 do 2 ili fuzijski protein prema zahtjevu 3, nukleinsku kiselinu ili ekspresivni vektor prema zahtjevu 6, stanicu prema zahtjevu 7, aktivirani T-limfocit prema zahtjevu 10 ili antitijelo prema zahtjevu 5 ili T-stanični receptor prema zahtjevu 4 i farmaceutski prihvatljivog nositelja i po potrebi farmaceutski prihvatljivog nositelja i/ili stabilizatora.
12. Peptid prema bilo kojem od zahtjeva 1 ili 2 ili fuzijski protein prema zahtjevu 3, nukleinska kiselina ili ekspresivni vektor prema zahtjevu 6, stanica prema zahtjevu 7, aktivirani T-limfocit prema zahtjevu 10 ili antitijelo prema zahtjevu 5 ili T-stanični receptor prema zahtjevu 4 za upotrebu u medicini, po mogućnosti za upotrebu u dijagnostici i/ili za liječenje karcinoma ili za upotrebu u proizvodnji lijeka protiv karcinoma.
13. Peptid prema bilo kojem od zahtjeva 1 ili 2 ili fuzijski protein prema zahtjevu 3, nukleinska kiselina ili ekspresivni vektor prema zahtjevu 6, stanica prema zahtjevu 7, aktivirani T-limfocit prema zahtjevu 10 ili antitijelo prema zahtjevu 5 ili T-stanični receptor prema zahtjevu 4, po mogućnosti za upotrebu u dijagnostici i/ili za liječenje karcinoma ili za upotrebu u proizvodnji lijeka protiv karcinoma prema zahtjevu 12,
pri čemu je navedeni karcinom karcinom jajnika, nemalostanični karcinom pluća, malostanični karcinom pluća, karcinom bubrega, karcinom mozga, karcinom debelog crijeva ili rektuma, karcinom želuca, karcinom jetre, karcinom pankreasa, karcinom prostate, leukemija, karcinom dojke, karcinom Merkelovih stanica, melanom, karcinom ezofalgusa, karcinom mjehura, karcinom uterusa, karcinom žučnog mjehura, karcinom žučnih vodova ili drugi karcinomi koji pokazuje prekomjernu ekspresiju proteina iz kojeg je izveden peptid prema SEQ ID br. 4, posebice karcinom jajnika.
14. Komplet koji sadrži:
a) posudu koja sadrži farmaceutski sastav koji sadrži peptid u skladu s bilo kojim od patentnih zahtjeva 1 ili 2, ili fuzijski protein prema zahtjevu 3, nukleinsku kiselinu ili ekspresijski vektor prema zahtjevu 6, stanicu prema zahtjevu 7, aktivirani T-limfocit prema zahtjevu 10 ili antitijela prema zahtjevu 5 ili T-stanični receptor prema zahtjevu 4, u otopini ili u liofiliziranom obliku;
b) drugu posudu koja sadrži diluens ili otopinu za rekonstituciju za liofiliziranu formulaciju;
c) najmanje jedan dodatni peptid iz skupine koja se sastoji od SEQ ID br. 1 do 3 i 5 do 48 i
d) upute za (i) uporabu otopine ili (ii) rekonstituciju i/ili uporabu liofilizirane formulacije i
e) nadalje jedan dodatni (iii) međuspremnik, (iv) diluens, (v) filtar, (vi) igla ili (v) štrcaljka.
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