HRP20210698T1 - Peptidi i kombinacija peptida za uporabu u imunoterapiji protiv karcinoma dojke i drugih karcinoma - Google Patents
Peptidi i kombinacija peptida za uporabu u imunoterapiji protiv karcinoma dojke i drugih karcinoma Download PDFInfo
- Publication number
- HRP20210698T1 HRP20210698T1 HRP20210698TT HRP20210698T HRP20210698T1 HR P20210698 T1 HRP20210698 T1 HR P20210698T1 HR P20210698T T HRP20210698T T HR P20210698TT HR P20210698 T HRP20210698 T HR P20210698T HR P20210698 T1 HRP20210698 T1 HR P20210698T1
- Authority
- HR
- Croatia
- Prior art keywords
- cancer
- peptide
- cell
- antibody
- nucleic acid
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims 20
- 102000004196 processed proteins & peptides Human genes 0.000 title claims 7
- 206010028980 Neoplasm Diseases 0.000 title claims 5
- 206010006187 Breast cancer Diseases 0.000 title claims 2
- 208000026310 Breast neoplasm Diseases 0.000 title claims 2
- 238000009169 immunotherapy Methods 0.000 title 1
- 108091008874 T cell receptors Proteins 0.000 claims 10
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 10
- 210000001744 T-lymphocyte Anatomy 0.000 claims 9
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 239000013604 expression vector Substances 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 229940041181 antineoplastic drug Drugs 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 239000012931 lyophilized formulation Substances 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 102000043129 MHC class I family Human genes 0.000 claims 1
- 108091054437 MHC class I family Proteins 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 230000002018 overexpression Effects 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/812—Breast
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Endocrinology (AREA)
- Marine Sciences & Fisheries (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
Claims (13)
1. Peptid koji se sastoji od slijeda aminokiselina prema SEQ ID br. 42; ili njegova farmaceutski prihvatljiva sol.
2. Peptid prema zahtjevu 1, koji navodi kako peptid uključuje nepeptidne vezove.
3. T-stanični receptor (TCR), po mogućnosti rekombinantni, topljiv ili na membranu vezan T-stanični receptor, koji je reaktivan s HLA ligandom, pri čemu navedeni ligand ima najmanje 88 % identičnosti prema aminokiselinskoj sekvenci u skladu s to SEQ ID br. 42 i po mogućnosti se sastoji od aminokiselinske sekvencije u skladu s SEQ ID br. 42.
4. Antitijelo, posebice topljivo ili na membranu vezano antitijelo, koje posebno prepoznaje peptide prema bilo kojem od zahtjeva 1 ili 2, po mogućnosti peptide prema zahtjevu 1 ili 2 kada se veže za MHC-molekule.
5. Nukleinska kiselina, koja kodira peptid prema bilo kojem od zahtjeva 1 ili 2 za TCR prema zahtjevu 3 ili antitijelo prema zahtjevu 4, opcionalno vezano na heterologni promotorski slijed ili ekspresijski vektor koji eksprimira navedenu nukleinsku kiselinu.
6. Rekombinantna stanica domaćin koja sadrži peptid prema zahtjevu 1 ili 2 ili nukleinsku kiselinu ili ekspresijski vektor prema zahtjevu 5, pri čemu navedena stanica domaćin po mogućnosti predstavlja antigen kao što je dendritička stanica ili gdje je navedena stanica domaćin po mogućnosti T-stanica ili NK stanica.
7. Metoda za proizvodnju peptida prema bilo kojem zahtjevu 1 ili 2 ili za proizvodnju T-staničnih receptora prema zahtjevu 3 ili antitijelo prema zahtjevu 4, metoda koja obuhvaća kultiviranje stanice domaćina prema zahtjevu 6, koja predstavlja peptide prema zahtjevu 1 do 3 ili ekspresivna nukleinska kiselina ili ekspresivni vektor prema zahtjevu 5 i izoliranje peptida ili njegovu varijantu ili TCR ili antitijelo od stanice domaćina ili njezinog medija za kultiviranje.
8. In vitro metoda za proizvodnju aktiviranih T-limfocita, metoda je koja obuhvaća kontaktiranje in vitro T-stanica humanim MHC molekulama klase I s umetnutim antigenima koje se eksprimiraju na površini odgovarajuće stanice koja prezentira antigen ili umjetnom konstrukcijom koja oponaša stanicu koja predstavlja antigen u vremenskom razdoblju dovoljnom da se aktiviraju navedene T-stanice na način svojstven antigenu, pri čemu je navedeni antigen peptid u skladu sa zahtjevom 1 ili 2.
9. Aktivirani T-limfocit, proizveden metodom u skladu s patentnim zahtjevom 8 koji selektivno prepoznaje stanicu koja predstavlja polipeptid koji sadrži sekvenciju aminokiseline sukladno zahtjevu 1 ili 2.
10. Farmaceutski sastav koji sadrži najmanje jedan aktivni sastojak, koji je odabran iz grupe peptida prema bilo kojem od zahtjeva 1 ili 2, nukleinsku kiselinu ili ekspresivni vektor prema zahtjevu 5, stanicu prema zahtjevu 6, aktivirani T-limfocit prema zahtjevu 9 ili antitijelo prema zahtjevu 4 ili T-stanični receptor prema zahtjevu 3 i farmaceutski prihvatljivog nositelja i po potrebi farmaceutski prihvatljivog nositelja i/ili stabilizatora.
11. Peptid prema bilo kojem od zahtjeva 1 ili 2, nukleinska kiselina ili ekspresivni vektor prema zahtjevu 5, stanica prema zahtjevu 6, aktivirani T-limfocit prema zahtjevu 9 ili antitijelo prema zahtjevu 4 ili T-stanični receptor prema zahtjevu 3 za upotrebu u medicini, po mogućnosti za upotrebu u dijagnostici i/ili za liječenje karcinoma ili za upotrebu u proizvodnji lijeka protiv karcinoma.
12. Peptid prema bilo kojem od zahtjeva 1 ili 2, nukleinska kiselina ili ekspresivni vektor prema zahtjevu 5, stanica prema zahtjevu 6, aktivirani T-limfocit prema zahtjevu 9 ili antitijelo prema zahtjevu 4 ili T-stanični receptor prema zahtjevu 3 za uporabu u dijagnostici i/ili za liječenje karcinoma ili za upotrebu u proizvodnji lijeka protiv karcinoma prema zahtjevu 11, pri čemu je karcinom karcinom pluća, karcinoma mozga, karcinom debelog crijeva, želuca, karcinom jetre, karcinom pankreasa, karcinom prostate, leukemija, karcinom dojke, melanoma, karcinom jajnika i karcinom ezofalgusa i drugi karcinom koji pokazuje prekomjernu ekspresiju proteina iz kojeg je izveden peptid prema SEQ ID br. 42.
13. Komplet koji sadrži:
a) posudu koja sadrži farmaceutski sastav koji sadrži peptid prema bilo kojem zahtjevu 1 do 2, nukleinsku kiselinu ili ekspresivni vektor prema zahtjevu 5, stanicu prema zahtjevu 6, aktivirani T-limfocit prema zahtjevu 9 ili antitijela prema zahtjevu 4 ili T-stanični receptor prema zahtjevu 3, u otopini ili u liofiliziranom obliku;
b) drugu posudu koja sadrži diluens ili otopinu za rekonstituciju za liofiliziranu formulaciju;
c) najmanje jedan dodatni peptid iz skupine koja se sastoji od SEQ ID br. 1 do 41 i 43 i
d) po potrebi, upute za (i) uporabu otopine ili (ii) rekonstituciju i/ili uporabu liofilizirane formulacije i
e) nadalje jedan dodatni (iii) međuspremnik, (iv) diluens, (v) filtar, (vi) igla ili (v) štrcaljka.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562270968P | 2015-12-22 | 2015-12-22 | |
GBGB1522667.3A GB201522667D0 (en) | 2015-12-22 | 2015-12-22 | Novel peptides and combination of peptides for use in immunotherapy against breast cancer and other cancers |
PCT/EP2016/079059 WO2017108345A1 (en) | 2015-12-22 | 2016-11-29 | Peptides and combination of peptides for use in immunotherapy against breast cancer and other cancers |
EP16802063.4A EP3394084B1 (en) | 2015-12-22 | 2016-11-29 | Peptides and combination of peptides for use in immunotherapy against breast cancer and other cancers |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20210698T1 true HRP20210698T1 (hr) | 2021-09-17 |
Family
ID=63849964
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20210698TT HRP20210698T1 (hr) | 2015-12-22 | 2021-05-05 | Peptidi i kombinacija peptida za uporabu u imunoterapiji protiv karcinoma dojke i drugih karcinoma |
Country Status (9)
Country | Link |
---|---|
US (11) | US10166278B2 (hr) |
CL (6) | CL2018001531A1 (hr) |
CY (1) | CY1124224T1 (hr) |
HR (1) | HRP20210698T1 (hr) |
IL (1) | IL258599A (hr) |
PH (1) | PH12018500864A1 (hr) |
SG (1) | SG10202111399YA (hr) |
TW (3) | TWI720424B (hr) |
ZA (1) | ZA201801036B (hr) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2900004T3 (es) | 2013-08-05 | 2022-03-15 | Immatics Biotechnologies Gmbh | Nueva inmunoterapia contra diversos tumores como el cáncer de pulmón, incluido el carcinoma de pulmón amicrocítico (NSCLC) |
US20170107216A1 (en) | 2015-10-19 | 2017-04-20 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
AU2016358100B2 (en) | 2015-11-19 | 2021-05-27 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
DK3394033T3 (da) | 2015-12-22 | 2021-01-04 | Incyte Corp | Heterocykliske forbindelser som immunmodulatorer |
MA44860A (fr) | 2016-05-06 | 2019-03-13 | Incyte Holdings Corp | Composés hétérocycliques utilisés comme immunomodulateurs |
US20170342060A1 (en) | 2016-05-26 | 2017-11-30 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
BR112018076534A2 (pt) | 2016-06-20 | 2019-04-02 | Incyte Corporation | compostos heterocíclicos como imunomoduladores |
ES2930092T3 (es) | 2016-07-14 | 2022-12-07 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
EP3504198B1 (en) | 2016-08-29 | 2023-01-25 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
EP3558989B1 (en) | 2016-12-22 | 2021-04-14 | Incyte Corporation | Triazolo[1,5-a]pyridine derivatives as immunomodulators |
EP3558985B1 (en) | 2016-12-22 | 2022-09-07 | Incyte Corporation | Benzooxazole derivatives as immunomodulators |
MA47120A (fr) | 2016-12-22 | 2021-04-28 | Incyte Corp | Dérivés pyridine utilisés en tant qu'immunomodulateurs |
MY197501A (en) | 2016-12-22 | 2023-06-19 | Incyte Corp | Tetrahydro imidazo[4,5-c]pyridine derivatives as pd-l1 internalization inducers |
CR20200520A (es) | 2018-03-30 | 2021-03-09 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
EP3790877B1 (en) | 2018-05-11 | 2023-03-01 | Incyte Corporation | Tetrahydro-imidazo[4,5-c]pyridine derivatives as pd-l1 immunomodulators |
TW202115059A (zh) | 2019-08-09 | 2021-04-16 | 美商英塞特公司 | Pd—1/pd—l1抑制劑之鹽 |
TW202126652A (zh) | 2019-09-30 | 2021-07-16 | 美商英塞特公司 | 作為免疫調節劑之吡啶并[3,2—d]嘧啶化合物 |
AU2020385113A1 (en) | 2019-11-11 | 2022-05-19 | Incyte Corporation | Salts and crystalline forms of a PD-1/PD-L1 inhibitor |
WO2022099018A1 (en) | 2020-11-06 | 2022-05-12 | Incyte Corporation | Process of preparing a pd-1/pd-l1 inhibitor |
TW202233615A (zh) | 2020-11-06 | 2022-09-01 | 美商英塞特公司 | Pd—1/pd—l1抑制劑之結晶形式 |
CA3200844A1 (en) | 2020-11-06 | 2022-05-12 | Incyte Corporation | Process for making a pd-1/pd-l1 inhibitor and salts and crystalline forms thereof |
WO2024006821A2 (en) * | 2022-06-30 | 2024-01-04 | Lonza Sales Ag | Methods of treating a tumor |
CN116042823B (zh) * | 2022-09-19 | 2024-03-29 | 广东省人民医院 | 用于食管鳞癌预后及疗法疗效评估的分子标记物及其应用 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9805877D0 (en) * | 1998-03-20 | 1998-05-13 | Imp Cancer Res Tech | Cancer |
US7211649B1 (en) * | 1999-07-02 | 2007-05-01 | Ana Mar Medical Ab | Cartilage intermediate layer protein |
CA2492070A1 (en) | 1999-12-01 | 2001-06-07 | Kevin P. Baker | Lung tumor marker pro4329 polypeptides and nucleic acids encoding the same |
AU2273701A (en) | 1999-12-13 | 2001-06-18 | Epimmune, Inc. | Hla class i a2 tumor associated antigen peptides and vaccine compositions |
ATE389668T1 (de) | 2000-07-31 | 2008-04-15 | Greenpeptide Co Ltd | Tumorantigen |
WO2002016939A2 (en) | 2000-08-18 | 2002-02-28 | Eos Biotechnology, Inc. | Methods of diagnosis of cancer and screening for cancer modulators |
US7919467B2 (en) | 2000-12-04 | 2011-04-05 | Immunotope, Inc. | Cytotoxic T-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of cancer |
US6535424B2 (en) * | 2001-07-25 | 2003-03-18 | Advanced Micro Devices, Inc. | Voltage boost circuit using supply voltage detection to compensate for supply voltage variations in read mode voltage |
DE10225144A1 (de) | 2002-05-29 | 2003-12-18 | Immatics Biotechnologies Gmbh | An MHC-Moleküle bindende Tumor-assoziierte Peptide |
WO2005007090A2 (en) * | 2003-07-03 | 2005-01-27 | President And Fellows Of Harvard College | Inhibitors of the map kinase pathway |
JP2008505648A (ja) | 2004-07-07 | 2008-02-28 | メタボレックス インコーポレーティッド | 糖尿病およびインスリン抵抗性の診断および治療の方法 |
FR2894985B1 (fr) | 2005-12-20 | 2008-01-18 | Alcan Rhenalu Sa | Tole en aluminium-cuivre-lithium a haute tenacite pour fuselage d'avion |
EP2052088A2 (en) | 2006-08-02 | 2009-04-29 | Genizon Biosciences | Genemap of the human genes associated with psoriasis |
AU2008317374B2 (en) | 2007-10-23 | 2015-03-19 | The Regents Of The University Of Colorado | Competitive inhibitors of invariant chain expression and/or ectopic clip binding |
ES2532896T5 (es) | 2008-05-14 | 2018-03-20 | Immatics Biotechnologies Gmbh | Péptidos del MHC de clase II novedosos y potentes derivados de survivina y neurocan |
WO2013040142A2 (en) | 2011-09-16 | 2013-03-21 | Iogenetics, Llc | Bioinformatic processes for determination of peptide binding |
WO2011119484A1 (en) | 2010-03-23 | 2011-09-29 | Iogenetics, Llc | Bioinformatic processes for determination of peptide binding |
WO2014010231A1 (en) | 2012-07-10 | 2014-01-16 | Oncotherapy Science, Inc. | Kif20a epitope peptides for th1 cells and vaccines containing the same |
GB201214007D0 (en) * | 2012-08-07 | 2012-09-19 | Scancell Ltd | Anti-tumour immune responses to modified self-epitopes |
TWI777198B (zh) | 2013-08-05 | 2022-09-11 | 德商伊瑪提克斯生物科技有限公司 | 新穎肽類,細胞及其用於治療多種腫瘤的用途,其製造方法及包含其等之醫藥組成物(七) |
GB201319446D0 (en) * | 2013-11-04 | 2013-12-18 | Immatics Biotechnologies Gmbh | Personalized immunotherapy against several neuronal and brain tumors |
GB201408255D0 (en) | 2014-05-09 | 2014-06-25 | Immatics Biotechnologies Gmbh | Novel immunotherapy against several tumours of the blood, such as acute myeloid leukemia (AML) |
-
2016
- 2016-11-29 SG SG10202111399YA patent/SG10202111399YA/en unknown
- 2016-12-22 TW TW108105097A patent/TWI720424B/zh active
- 2016-12-22 TW TW111119458A patent/TW202241939A/zh unknown
- 2016-12-22 TW TW109134386A patent/TWI768491B/zh active
-
2018
- 2018-02-15 ZA ZA2018/01036A patent/ZA201801036B/en unknown
- 2018-04-10 IL IL258599A patent/IL258599A/en unknown
- 2018-04-23 PH PH12018500864A patent/PH12018500864A1/en unknown
- 2018-06-08 CL CL2018001531A patent/CL2018001531A1/es unknown
- 2018-06-29 US US16/024,164 patent/US10166278B2/en active Active
- 2018-06-29 US US16/024,142 patent/US10143733B2/en active Active
- 2018-06-29 US US16/024,133 patent/US10143732B2/en active Active
- 2018-11-01 US US16/177,919 patent/US10238728B2/en active Active
- 2018-12-05 US US16/210,357 patent/US10376569B2/en active Active
-
2019
- 2019-06-28 US US16/456,815 patent/US10485859B2/en active Active
- 2019-09-25 US US16/582,096 patent/US10596243B2/en active Active
- 2019-10-16 CL CL2019002939A patent/CL2019002939A1/es unknown
- 2019-10-16 CL CL2019002940A patent/CL2019002940A1/es unknown
- 2019-10-16 CL CL2019002941A patent/CL2019002941A1/es unknown
-
2020
- 2020-01-24 US US16/752,156 patent/US10675338B1/en active Active
- 2020-05-01 US US16/864,558 patent/US11065314B2/en active Active
-
2021
- 2021-05-05 HR HRP20210698TT patent/HRP20210698T1/hr unknown
- 2021-05-28 US US17/333,902 patent/US20210290743A1/en active Pending
- 2021-06-10 CY CY20211100515T patent/CY1124224T1/el unknown
- 2021-09-29 CL CL2021002524A patent/CL2021002524A1/es unknown
- 2021-09-29 CL CL2021002525A patent/CL2021002525A1/es unknown
-
2022
- 2022-09-16 US US17/932,836 patent/US20230101093A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20210698T1 (hr) | Peptidi i kombinacija peptida za uporabu u imunoterapiji protiv karcinoma dojke i drugih karcinoma | |
HRP20210709T1 (hr) | Peptidi i kombinacija peptida za imunoterapiju protiv karcinoma prostate i druge vrste karcinoma | |
HRP20201281T1 (hr) | Novi peptidi i kombinacija peptida za uporabu u imunoterapiji protiv epitelnog karcinoma jajnika i drugih karcinoma | |
HRP20202019T1 (hr) | Novi peptidi i kombinacija peptida za uporabu u imunoterapiji protiv raka jajnika i drugih malignih tumora | |
HRP20210076T1 (hr) | Novi peptidi i kombinacija peptida za uporabu u imunoterapiji protiv karcinoma ezofagusa i drugih karcinoma | |
AR121383A2 (es) | Péptidos y combinación de péptidos y andamiajes para su uso en inmunoterapia contra carcinoma de células renales (rcc) y otros cánceres | |
JP2019513005A5 (hr) | ||
RU2020113032A (ru) | Новые пептиды и комбинации пептидов для применения в иммунотерапии рака легких, в том числе немелкоклеточного рака легких (нмрл) и других видов рака | |
HRP20230512T1 (hr) | Novi peptidi i kombinacija peptida za uporabu u imunoterapiji protiv karcinoma jajnika i drugih karcinoma | |
JP2019516663A5 (hr) | ||
HRP20201467T1 (hr) | Nova imunoterapija protiv raznih vrsta karcinoma, uključujući gastrointestinalni karcinom i gastrični karcinom | |
HRP20192262T1 (hr) | Nova imunoterapija protiv nekoliko tumora, kao što su rak pluća, uključujući mikrocelularni karcinom pluća (nsclc) | |
AR106920A1 (es) | Péptidos y combinaciones de péptidos para el uso en la inmunoterapia contra la leucemia linfocítica crónica (llc) y otros tipos de cáncer | |
CA2942557C (en) | Methods for isolating and proliferating autologous cancer antigen-specific cd8+ t cells | |
HRP20230878T1 (hr) | Novi peptidi i kombinacija peptida za uporabu u imunoterapiji protiv raznih karcinoma (seq id 25 - mrax5-003) | |
JP2019511214A5 (hr) | ||
JP2019515650A5 (hr) | ||
JP2012504393A5 (hr) | ||
JP2011520436A5 (hr) | ||
JP2019515653A5 (hr) | ||
JP2020516681A5 (hr) | ||
JP6755465B2 (ja) | 共発現プラスミド | |
JP2019520038A5 (hr) | ||
JP2019536426A5 (hr) | ||
HRP20210528T1 (hr) | Novi peptidi i kombinacija peptida i njihovih skela za uporabu u imunoterapiji protiv kolorektalnog karcinoma i drugih karcinoma |