HRP20230878T1 - Novi peptidi i kombinacija peptida za uporabu u imunoterapiji protiv raznih karcinoma (seq id 25 - mrax5-003) - Google Patents

Novi peptidi i kombinacija peptida za uporabu u imunoterapiji protiv raznih karcinoma (seq id 25 - mrax5-003) Download PDF

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HRP20230878T1
HRP20230878T1 HRP20230878TT HRP20230878T HRP20230878T1 HR P20230878 T1 HRP20230878 T1 HR P20230878T1 HR P20230878T T HRP20230878T T HR P20230878TT HR P20230878 T HRP20230878 T HR P20230878T HR P20230878 T1 HRP20230878 T1 HR P20230878T1
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Croatia
Prior art keywords
cell
peptide
cancer
seq
antibody
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HRP20230878TT
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English (en)
Inventor
Andrea Mahr
Lea Stevermann
Toni Weinschenk
Oliver Schoor
Jens Fritsche
Harpreet Singh
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Immatics Biotechnologies Gmbh
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Priority claimed from GBGB1505305.1A external-priority patent/GB201505305D0/en
Application filed by Immatics Biotechnologies Gmbh filed Critical Immatics Biotechnologies Gmbh
Publication of HRP20230878T1 publication Critical patent/HRP20230878T1/hr
Publication of HRP20230878T8 publication Critical patent/HRP20230878T8/hr

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Claims (14)

1. Peptid koji sadrži aminokiselinsku sekvencu koja se sastoji od SEQ ID br. 25; i njegova farmaceutski prihvatljiva sol, pri čemu navedeni peptid ima ukupnu duljinu od 11 do 16 aminokiselina.
2. Peptid prema zahtjevu 1, pri čemu se spomenuti peptid sastoji od aminokiselinske sekvence prema SEQ ID br. 25.
3. Peptid prema zahtjevu 1 ili 2, pri čemu navedeni peptid uključuje nepeptidne veze.
4. T-stanični receptor, po mogućnosti rekombinantni, topljiv ili na membranu vezan T-stanični receptor, koji je reaktivan s HLA ligandom zajedno s HLA, pri čemu navedeni ligand ima najmanje 88 % identičnosti prema aminokiselinskoj sekvenci u skladu s to SEQ ID br. 25 i po mogućnosti se sastoji od aminokiselinske sekvencije u skladu s SEQ ID br. 25.
5. Antitijelo, posebice topljivo ili na membranu vezano antitijelo, koje posebno prepoznaje peptid koji se sastoji od aminokiselinske sekvence prema zahtjevu SEQ ID br. 25 kada se veže za MHC-molekule.
6. Nukleinska kiselina, koja kodira peptid prema bilo kojem od zahtjeva 1 do 3 ili TCR prema zahtjevu 4 ili antitijelo prema zahtjevu 5, opcionalno vezano na heterologni promotorski slijed ili ekspresivni vektor koji sadrži navedenu nukleinsku kiselinu.
7. Rekombinantna stanica domaćin koja sadrži peptid prema bilo kojem zahtjevu 1 do 3 ili nukleinsku kiselinu ili ekspresivni vektor prema zahtjevu 6, pri čemu navedena stanica domaćin po mogućnosti predstavlja stanicu koja predstavlja antigen kao što je dendritička stanica ili gdje je navedena stanica domaćin po mogućnosti T-stanica ili NK stanica.
8. Metoda za proizvodnju peptida prema bilo kojem zahtjevu 1 do 3 ili za proizvodnju T-staničnih receptora prema zahtjevu 4 ili antitijelo prema zahtjevu 5, metoda koja obuhvaća kultiviranje stanice domaćina prema zahtjevu 8, koja predstavlja peptid prema bilo kojem zahtjevu 1 do 3 ili ekspresivna nukleinska kiselina ili ekspresivni vektor prema zahtjevu 7 i izoliranje peptida ili TCR ili antitijelo od stanice domaćina ili njezinog medija za kultiviranje.
9. In vitro metoda za proizvodnju aktiviranih T-limfocita, metoda je koja obuhvaća kontaktiranje in vitro T-stanica humanim MHC molekulama klase I s umetnutim antigenima koje se eksprimiraju na površini odgovarajuće stanice koja prezentira antigen ili umjetnom konstrukcijom koja oponaša stanicu koja predstavlja antigen u vremenskom razdoblju dovoljnom da se aktiviraju navedene T-stanice na način svojstven antigenu, pri čemu je navedeni antigen peptid koji se sastoji od aminokiselinske sekvence prema zahtjevu SEQ ID br. 25.
10. Aktivirani T-limfocit, proizveden metodom u skladu s patentnim zahtjevom 9 koji selektivno prepoznaje stanicu koja predstavlja polipeptid koji sadrži sekvenciju aminokiseline sukladno zahtjevu 1 ili 2.
11. Farmaceutski sastav koji sadrži najmanje jedan aktivni sastojak, koji je odabran iz grupe koji se sastoji od peptida prema bilo kojem od zahtjeva 1 do 3, nukleinsku kiselinu ili ekspresivni vektor prema zahtjevu 6, stanicu prema zahtjevu 7, aktivirani T-limfocit prema zahtjevu 10 ili antitijelo prema zahtjevu 5 ili T-stanični receptor prema zahtjevu 5 i farmaceutski prihvatljivog nositelja i po potrebi farmaceutski prihvatljivog nositelja i/ili stabilizatora.
12. Peptid prema bilo kojem od zahtjeva 1 do 3, nukleinska kiselina ili ekspresivni vektor prema zahtjevu 6, stanica prema zahtjevu 7, aktivirani T-limfocit prema zahtjevu 10 ili antitijelo prema zahtjevu 5 ili T-stanični receptor prema zahtjevu 5 za upotrebu u medicini, po mogućnosti za upotrebu u dijagnostici i/ili za liječenje karcinoma ili za upotrebu u proizvodnji lijeka protiv karcinoma.
13. Peptid prema bilo kojem od zahtjeva 1 ili 3, nukleinska kiselina ili ekspresivni vektor prema zahtjevu 6, stanica prema zahtjevu 7, aktivirani T-limfocit prema zahtjevu 10 ili antitijelo prema zahtjevu 5 ili T-stanični receptor prema zahtjevu 4 za uporabu u dijagnostici i/ili za liječenje karcinoma ili za upotrebu u proizvodnji lijeka protiv karcinoma prema zahtjevu 13, pri čemu je navedeni karcinom odabran iz grupe hepatocelularnih karcinoma (HCC), kolorektalnih karcinoma (CRC), glioblastoma (GB), želučanih karcinoma (GC), ezofagialnih karcinoma, nemalostaničnih karcinoma pluća (NSCLC), karcinoma pankreasa (PC), karcinoma bubrega (RCC), benigne hiperplazije prostate (BPH), karcinoma prostate (PCA), karcinom jajnika (OC), melanoma, karcinoma dojke, kronične limfocitne leukemije (CLL), karcinoma Merkolivih ćelija (MCC), malostaničnih karcinoma pluća (SCLC), Non-Hodgkin limfoma (NHL), akutne mijeolične leukemije (AML), karcinoma žučnjaka i kolangiokarcinoma (GBC, CCC), karcinoma mokraćnog mjehura (UBC), karcinoma uterusa (UEC, i drugih karcinoma koji pokazuju prekomjernu ekspresiju proteina iz kojeg je izveden peptid prema SEQ ID br. 25.
14. Komplet koji sadrži: a) posudu koja sadrži farmaceutski sastav koji sadrži peptid prema bilo kojem zahtjevu 1 do 3, nukleinsku kiselinu ili ekspresivni vektor prema zahtjevu 6, stanicu prema zahtjevu 7, aktivirani T-limfocit prema zahtjevu 10 ili antitijela prema zahtjevu 5 ili T-stanični receptor prema zahtjevu 4, u otopini ili u liofiliziranom obliku; b) po potrebi drugu posudu koja sadrži diluens ili otopinu za rekonstituciju za liofiliziranu formulaciju; c) po potrebi, upute za (i) uporabu otopine ili (ii) rekonstituciju i/ili uporabu liofilizirane formulacije i d) nadalje jedan dodatni (iii) međuspremnik, (iv) diluens, (v) filtar, (vi) igla ili (vii) štrcaljka.
HRP20230878TT 2015-03-27 2016-03-24 Novi peptidi i kombinacija peptida za uporabu u imunoterapiji protiv raznih karcinoma (seq id 25 - mrax5-003) HRP20230878T8 (hr)

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