HRP20230878T1 - Novi peptidi i kombinacija peptida za uporabu u imunoterapiji protiv raznih karcinoma (seq id 25 - mrax5-003) - Google Patents
Novi peptidi i kombinacija peptida za uporabu u imunoterapiji protiv raznih karcinoma (seq id 25 - mrax5-003) Download PDFInfo
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- HRP20230878T1 HRP20230878T1 HRP20230878TT HRP20230878T HRP20230878T1 HR P20230878 T1 HRP20230878 T1 HR P20230878T1 HR P20230878T T HRP20230878T T HR P20230878TT HR P20230878 T HRP20230878 T HR P20230878T HR P20230878 T1 HRP20230878 T1 HR P20230878T1
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- 108090000765 processed proteins & peptides Proteins 0.000 title claims 21
- 206010028980 Neoplasm Diseases 0.000 title claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 title claims 3
- 238000009169 immunotherapy Methods 0.000 title 1
- 210000004027 cell Anatomy 0.000 claims 11
- 210000001744 T-lymphocyte Anatomy 0.000 claims 9
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 108091008874 T cell receptors Proteins 0.000 claims 7
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- 239000013604 expression vector Substances 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 239000000427 antigen Substances 0.000 claims 3
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 3
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- 102000036639 antigens Human genes 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
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- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 206010041067 Small cell lung cancer Diseases 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 229940041181 antineoplastic drug Drugs 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
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- 238000000338 in vitro Methods 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
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- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
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- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 2
- 201000000498 stomach carcinoma Diseases 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000022072 Gallbladder Neoplasms Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 102000043129 MHC class I family Human genes 0.000 claims 1
- 108091054437 MHC class I family Proteins 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
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- 239000004480 active ingredient Substances 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 1
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- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 230000002018 overexpression Effects 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
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- 150000003839 salts Chemical class 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
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Claims (14)
1. Peptid koji sadrži aminokiselinsku sekvencu koja se sastoji od SEQ ID br. 25; i njegova farmaceutski prihvatljiva sol, pri čemu navedeni peptid ima ukupnu duljinu od 11 do 16 aminokiselina.
2. Peptid prema zahtjevu 1, pri čemu se spomenuti peptid sastoji od aminokiselinske sekvence prema SEQ ID br. 25.
3. Peptid prema zahtjevu 1 ili 2, pri čemu navedeni peptid uključuje nepeptidne veze.
4. T-stanični receptor, po mogućnosti rekombinantni, topljiv ili na membranu vezan T-stanični receptor, koji je reaktivan s HLA ligandom zajedno s HLA, pri čemu navedeni ligand ima najmanje 88 % identičnosti prema aminokiselinskoj sekvenci u skladu s to SEQ ID br. 25 i po mogućnosti se sastoji od aminokiselinske sekvencije u skladu s SEQ ID br. 25.
5. Antitijelo, posebice topljivo ili na membranu vezano antitijelo, koje posebno prepoznaje peptid koji se sastoji od aminokiselinske sekvence prema zahtjevu SEQ ID br. 25 kada se veže za MHC-molekule.
6. Nukleinska kiselina, koja kodira peptid prema bilo kojem od zahtjeva 1 do 3 ili TCR prema zahtjevu 4 ili antitijelo prema zahtjevu 5, opcionalno vezano na heterologni promotorski slijed ili ekspresivni vektor koji sadrži navedenu nukleinsku kiselinu.
7. Rekombinantna stanica domaćin koja sadrži peptid prema bilo kojem zahtjevu 1 do 3 ili nukleinsku kiselinu ili ekspresivni vektor prema zahtjevu 6, pri čemu navedena stanica domaćin po mogućnosti predstavlja stanicu koja predstavlja antigen kao što je dendritička stanica ili gdje je navedena stanica domaćin po mogućnosti T-stanica ili NK stanica.
8. Metoda za proizvodnju peptida prema bilo kojem zahtjevu 1 do 3 ili za proizvodnju T-staničnih receptora prema zahtjevu 4 ili antitijelo prema zahtjevu 5, metoda koja obuhvaća kultiviranje stanice domaćina prema zahtjevu 8, koja predstavlja peptid prema bilo kojem zahtjevu 1 do 3 ili ekspresivna nukleinska kiselina ili ekspresivni vektor prema zahtjevu 7 i izoliranje peptida ili TCR ili antitijelo od stanice domaćina ili njezinog medija za kultiviranje.
9. In vitro metoda za proizvodnju aktiviranih T-limfocita, metoda je koja obuhvaća kontaktiranje in vitro T-stanica humanim MHC molekulama klase I s umetnutim antigenima koje se eksprimiraju na površini odgovarajuće stanice koja prezentira antigen ili umjetnom konstrukcijom koja oponaša stanicu koja predstavlja antigen u vremenskom razdoblju dovoljnom da se aktiviraju navedene T-stanice na način svojstven antigenu, pri čemu je navedeni antigen peptid koji se sastoji od aminokiselinske sekvence prema zahtjevu SEQ ID br. 25.
10. Aktivirani T-limfocit, proizveden metodom u skladu s patentnim zahtjevom 9 koji selektivno prepoznaje stanicu koja predstavlja polipeptid koji sadrži sekvenciju aminokiseline sukladno zahtjevu 1 ili 2.
11. Farmaceutski sastav koji sadrži najmanje jedan aktivni sastojak, koji je odabran iz grupe koji se sastoji od peptida prema bilo kojem od zahtjeva 1 do 3, nukleinsku kiselinu ili ekspresivni vektor prema zahtjevu 6, stanicu prema zahtjevu 7, aktivirani T-limfocit prema zahtjevu 10 ili antitijelo prema zahtjevu 5 ili T-stanični receptor prema zahtjevu 5 i farmaceutski prihvatljivog nositelja i po potrebi farmaceutski prihvatljivog nositelja i/ili stabilizatora.
12. Peptid prema bilo kojem od zahtjeva 1 do 3, nukleinska kiselina ili ekspresivni vektor prema zahtjevu 6, stanica prema zahtjevu 7, aktivirani T-limfocit prema zahtjevu 10 ili antitijelo prema zahtjevu 5 ili T-stanični receptor prema zahtjevu 5 za upotrebu u medicini, po mogućnosti za upotrebu u dijagnostici i/ili za liječenje karcinoma ili za upotrebu u proizvodnji lijeka protiv karcinoma.
13. Peptid prema bilo kojem od zahtjeva 1 ili 3, nukleinska kiselina ili ekspresivni vektor prema zahtjevu 6, stanica prema zahtjevu 7, aktivirani T-limfocit prema zahtjevu 10 ili antitijelo prema zahtjevu 5 ili T-stanični receptor prema zahtjevu 4 za uporabu u dijagnostici i/ili za liječenje karcinoma ili za upotrebu u proizvodnji lijeka protiv karcinoma prema zahtjevu 13, pri čemu je navedeni karcinom odabran iz grupe hepatocelularnih karcinoma (HCC), kolorektalnih karcinoma (CRC), glioblastoma (GB), želučanih karcinoma (GC), ezofagialnih karcinoma, nemalostaničnih karcinoma pluća (NSCLC), karcinoma pankreasa (PC), karcinoma bubrega (RCC), benigne hiperplazije prostate (BPH), karcinoma prostate (PCA), karcinom jajnika (OC), melanoma, karcinoma dojke, kronične limfocitne leukemije (CLL), karcinoma Merkolivih ćelija (MCC), malostaničnih karcinoma pluća (SCLC), Non-Hodgkin limfoma (NHL), akutne mijeolične leukemije (AML), karcinoma žučnjaka i kolangiokarcinoma (GBC, CCC), karcinoma mokraćnog mjehura (UBC), karcinoma uterusa (UEC, i drugih karcinoma koji pokazuju prekomjernu ekspresiju proteina iz kojeg je izveden peptid prema SEQ ID br. 25.
14. Komplet koji sadrži:
a) posudu koja sadrži farmaceutski sastav koji sadrži peptid prema bilo kojem zahtjevu 1 do 3, nukleinsku kiselinu ili ekspresivni vektor prema zahtjevu 6, stanicu prema zahtjevu 7, aktivirani T-limfocit prema zahtjevu 10 ili antitijela prema zahtjevu 5 ili T-stanični receptor prema zahtjevu 4, u otopini ili u liofiliziranom obliku;
b) po potrebi drugu posudu koja sadrži diluens ili otopinu za rekonstituciju za liofiliziranu formulaciju;
c) po potrebi, upute za (i) uporabu otopine ili (ii) rekonstituciju i/ili uporabu liofilizirane formulacije i
d) nadalje jedan dodatni (iii) međuspremnik, (iv) diluens, (v) filtar, (vi) igla ili (vii) štrcaljka.
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