BRPI0815578B8 - peptídeos, agentes farmacêuticos compreendendo os mesmos, métodos in vitro para induzir uma célula apresentadora de antígeno, usos dos referidos peptídeos, e vacina - Google Patents
peptídeos, agentes farmacêuticos compreendendo os mesmos, métodos in vitro para induzir uma célula apresentadora de antígeno, usos dos referidos peptídeos, e vacinaInfo
- Publication number
- BRPI0815578B8 BRPI0815578B8 BRPI0815578A BRPI0815578A BRPI0815578B8 BR PI0815578 B8 BRPI0815578 B8 BR PI0815578B8 BR PI0815578 A BRPI0815578 A BR PI0815578A BR PI0815578 A BRPI0815578 A BR PI0815578A BR PI0815578 B8 BRPI0815578 B8 BR PI0815578B8
- Authority
- BR
- Brazil
- Prior art keywords
- peptides
- inducing
- vaccine
- peptide
- same
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 9
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 230000001939 inductive effect Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 210000000612 antigen-presenting cell Anatomy 0.000 title abstract 2
- 238000000338 in vitro Methods 0.000 title abstract 2
- 239000008177 pharmaceutical agent Substances 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 210000001239 CD8-positive, alpha-beta cytotoxic T lymphocyte Anatomy 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4615—Dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4622—Antigen presenting cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
peptídeos, agentes farmacêuticos compreendendo os mesmos, métodos in vitro para induzir uma célula apresentadora de antígeno, usos dos referidos peptídeos, e vacina. a presente invenção refere-se a um peptídeo de (a) ou (b) abaixo, e métodos de uso do peptídeo: (a) um peptídeo incluindo a sequência de aminoácido da seq id no: 1 ou 2, (b) um peptídeo que inclui a sequência de aminoácido da seq id no: 1 ou 2, em que um, dois, ou vários aminoácidos são substituídos, suprimidos, inseridos, e/ou adicionados, e em que o peptídeo mostra atividade de indução de célula t killer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007214000 | 2007-08-20 | ||
PCT/JP2008/060837 WO2009025117A1 (ja) | 2007-08-20 | 2008-06-13 | Cdca1ペプチド及びこれを含む薬剤 |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0815578A2 BRPI0815578A2 (pt) | 2015-02-18 |
BRPI0815578B1 BRPI0815578B1 (pt) | 2020-04-07 |
BRPI0815578B8 true BRPI0815578B8 (pt) | 2021-05-25 |
Family
ID=40378024
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0815578A BRPI0815578B8 (pt) | 2007-08-20 | 2008-06-13 | peptídeos, agentes farmacêuticos compreendendo os mesmos, métodos in vitro para induzir uma célula apresentadora de antígeno, usos dos referidos peptídeos, e vacina |
Country Status (19)
Country | Link |
---|---|
US (1) | US8598125B2 (pt) |
EP (1) | EP2186889B1 (pt) |
JP (1) | JP5493076B2 (pt) |
KR (1) | KR101610353B1 (pt) |
CN (1) | CN101835892B (pt) |
AU (1) | AU2008290061B2 (pt) |
BR (1) | BRPI0815578B8 (pt) |
CA (1) | CA2696701C (pt) |
DK (1) | DK2186889T3 (pt) |
ES (1) | ES2537323T3 (pt) |
HK (1) | HK1141312A1 (pt) |
IL (1) | IL203898A (pt) |
MX (1) | MX2010002001A (pt) |
PL (1) | PL2186889T3 (pt) |
PT (1) | PT2186889E (pt) |
RU (2) | RU2486195C2 (pt) |
SG (1) | SG183698A1 (pt) |
TW (1) | TWI523660B (pt) |
WO (1) | WO2009025117A1 (pt) |
Families Citing this family (17)
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EP1915622A2 (en) | 2005-07-29 | 2008-04-30 | Oncotherapy Science, Inc. | Screening and therapeutic method for nsclc targeting cdca1-kntc2 complex |
PT2186889E (pt) | 2007-08-20 | 2015-06-17 | Oncotherapy Science Inc | Péptido cdca1 e agente farmacêutico que o compreende |
WO2009025196A1 (ja) | 2007-08-20 | 2009-02-26 | Oncotherapy Science, Inc. | Foxm1ペプチドおよびこれを含む薬剤 |
TWI526219B (zh) * | 2008-06-19 | 2016-03-21 | 腫瘤療法 科學股份有限公司 | Cdca1抗原決定位胜肽及含此胜肽的疫苗 |
TWI469791B (zh) | 2009-02-18 | 2015-01-21 | Oncotherapy Science Inc | Foxm1胜肽以及含此胜肽之疫苗 |
CN105648056A (zh) * | 2010-05-14 | 2016-06-08 | 综合医院公司 | 鉴定肿瘤特异性新抗原的组合物和方法 |
KR20140138900A (ko) | 2012-03-09 | 2014-12-04 | 온코세라피 사이언스 가부시키가이샤 | 펩티드를 포함한 의약 조성물 |
EP2872532A4 (en) * | 2012-07-10 | 2016-04-13 | Oncotherapy Science Inc | CDCA1-EPITOPPEPTIDES FOR TH1 CELLS AND VACCINES THEREWITH |
WO2015077717A1 (en) | 2013-11-25 | 2015-05-28 | The Broad Institute Inc. | Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status |
US11725237B2 (en) | 2013-12-05 | 2023-08-15 | The Broad Institute Inc. | Polymorphic gene typing and somatic change detection using sequencing data |
WO2015095811A2 (en) | 2013-12-20 | 2015-06-25 | The Board Institute Inc. | Combination therapy with neoantigen vaccine |
EP4282883A3 (en) * | 2014-08-04 | 2024-04-24 | OncoTherapy Science, Inc. | Cdca1-derived peptide and vaccine containing same |
WO2016100975A1 (en) | 2014-12-19 | 2016-06-23 | Massachsetts Institute Ot Technology | Molecular biomarkers for cancer immunotherapy |
GB201505305D0 (en) | 2015-03-27 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel Peptides and combination of peptides for use in immunotherapy against various tumors |
MY193703A (en) | 2015-03-27 | 2022-10-26 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against various tumors |
EP4029494A1 (en) | 2017-01-25 | 2022-07-20 | OSE Immunotherapeutics | Method for manufacturing a stable emulsion for peptide delivery |
TW202023581A (zh) | 2018-08-02 | 2020-07-01 | 日商腫瘤療法 科學股份有限公司 | 來自cdca1的胜肽及含有此的疫苗 |
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2008
- 2008-06-13 PT PT87771986T patent/PT2186889E/pt unknown
- 2008-06-13 CN CN2008801123961A patent/CN101835892B/zh active Active
- 2008-06-13 CA CA2696701A patent/CA2696701C/en active Active
- 2008-06-13 EP EP08777198.6A patent/EP2186889B1/en active Active
- 2008-06-13 DK DK08777198.6T patent/DK2186889T3/en active
- 2008-06-13 WO PCT/JP2008/060837 patent/WO2009025117A1/ja active Application Filing
- 2008-06-13 MX MX2010002001A patent/MX2010002001A/es active IP Right Grant
- 2008-06-13 ES ES08777198.6T patent/ES2537323T3/es active Active
- 2008-06-13 AU AU2008290061A patent/AU2008290061B2/en active Active
- 2008-06-13 KR KR1020107005388A patent/KR101610353B1/ko active IP Right Grant
- 2008-06-13 SG SG2012058327A patent/SG183698A1/en unknown
- 2008-06-13 RU RU2010110564/10A patent/RU2486195C2/ru active
- 2008-06-13 PL PL08777198T patent/PL2186889T3/pl unknown
- 2008-06-13 US US12/673,434 patent/US8598125B2/en active Active
- 2008-06-13 BR BRPI0815578A patent/BRPI0815578B8/pt active IP Right Grant
- 2008-06-13 JP JP2009528970A patent/JP5493076B2/ja active Active
- 2008-06-16 TW TW097122386A patent/TWI523660B/zh active
-
2010
- 2010-02-11 IL IL203898A patent/IL203898A/en active IP Right Grant
- 2010-08-13 HK HK10107732.6A patent/HK1141312A1/xx unknown
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2013
- 2013-03-20 RU RU2013112616/10A patent/RU2013112616A/ru not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
BRPI0815578B1 (pt) | 2020-04-07 |
TW200916114A (en) | 2009-04-16 |
IL203898A0 (en) | 2011-07-31 |
SG183698A1 (en) | 2012-09-27 |
KR101610353B1 (ko) | 2016-04-07 |
CA2696701A1 (en) | 2009-02-26 |
JP5493076B2 (ja) | 2014-05-14 |
PL2186889T3 (pl) | 2015-09-30 |
RU2013112616A (ru) | 2014-09-27 |
HK1141312A1 (en) | 2010-11-05 |
CN101835892B (zh) | 2013-11-06 |
IL203898A (en) | 2013-11-28 |
AU2008290061B2 (en) | 2014-01-30 |
CA2696701C (en) | 2017-01-24 |
RU2010110564A (ru) | 2011-09-27 |
RU2486195C2 (ru) | 2013-06-27 |
KR20100063060A (ko) | 2010-06-10 |
WO2009025117A1 (ja) | 2009-02-26 |
AU2008290061A1 (en) | 2009-02-26 |
JPWO2009025117A1 (ja) | 2010-11-18 |
DK2186889T3 (en) | 2015-06-08 |
EP2186889A1 (en) | 2010-05-19 |
BRPI0815578A2 (pt) | 2015-02-18 |
ES2537323T3 (es) | 2015-06-05 |
TWI523660B (zh) | 2016-03-01 |
EP2186889B1 (en) | 2015-04-01 |
MX2010002001A (es) | 2010-03-11 |
US20110152199A1 (en) | 2011-06-23 |
CN101835892A (zh) | 2010-09-15 |
US8598125B2 (en) | 2013-12-03 |
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