BR112015013183A2 - proteínas de fusão para uso como aperfeiçoadores imunogênicos para indução de respostas de células t específicas para antígenos - Google Patents

proteínas de fusão para uso como aperfeiçoadores imunogênicos para indução de respostas de células t específicas para antígenos

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Publication number
BR112015013183A2
BR112015013183A2 BR112015013183A BR112015013183A BR112015013183A2 BR 112015013183 A2 BR112015013183 A2 BR 112015013183A2 BR 112015013183 A BR112015013183 A BR 112015013183A BR 112015013183 A BR112015013183 A BR 112015013183A BR 112015013183 A2 BR112015013183 A2 BR 112015013183A2
Authority
BR
Brazil
Prior art keywords
specific
terminus
cell responses
fusion protein
sequence
Prior art date
Application number
BR112015013183A
Other languages
English (en)
Inventor
Wu Chia-Mao
Chang Hsiu-Kang
Wu Jiun-Ming
Chou Wei-I
Original Assignee
Thevax Genetics Vaccine Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thevax Genetics Vaccine Co Ltd filed Critical Thevax Genetics Vaccine Co Ltd
Publication of BR112015013183A2 publication Critical patent/BR112015013183A2/pt

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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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Abstract

resumo "proteínas de fusão para uso como aperfeiçoadores imunogênicos para indução de respostas de células t específicas para antígenos" o documento revela uma composição de vacina compreendendo uma proteína de fusão para induzir respostas de células t específicas e melhores de antígeno para agente patogênico. a proteína de fusão compreende: (a) um domínio de ligação de célula apresentadora de antígeno (apc) ou um domínio de ligação ao receptor cd91, localizado no término n da proteína de fusão; (b) um peptídeo de translocação de 34-112 resíduos de aminoácidos de comprimento, compreendendo uma sequência de aminoácidos que é pelo menos 90% idêntica à seq id no: 4, 2, 3, ou 6, localizada no término c do domínio de ligação à apc ou o domínio de ligação ao receptor cd91; e (c) um antígeno de um agente patogênico, localizado no término c do peptídeo de translocação; (d) um sinal de exportação nuclear, compreendendo a sequência de aminoácidos da seq id no: 13; e (e) uma sequência de retenção no retículo endoplasmático, localizada no término c da proteína de fusão.
BR112015013183A 2012-12-05 2013-12-03 proteínas de fusão para uso como aperfeiçoadores imunogênicos para indução de respostas de células t específicas para antígenos BR112015013183A2 (pt)

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