RU2015122368A - Слитые белки для применения в качестве иммуногенных усиливающих агентов для индуцирования антигенспецифического т-клеточного ответа - Google Patents
Слитые белки для применения в качестве иммуногенных усиливающих агентов для индуцирования антигенспецифического т-клеточного ответа Download PDFInfo
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- RU2015122368A RU2015122368A RU2015122368A RU2015122368A RU2015122368A RU 2015122368 A RU2015122368 A RU 2015122368A RU 2015122368 A RU2015122368 A RU 2015122368A RU 2015122368 A RU2015122368 A RU 2015122368A RU 2015122368 A RU2015122368 A RU 2015122368A
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- fusion protein
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- 239000000427 antigen Substances 0.000 title claims 8
- 102000036639 antigens Human genes 0.000 title claims 8
- 108091007433 antigens Proteins 0.000 title claims 8
- 230000005867 T cell response Effects 0.000 title claims 2
- 230000001939 inductive effect Effects 0.000 title claims 2
- 230000002163 immunogen Effects 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 239000012744 reinforcing agent Substances 0.000 title 1
- 108020001507 fusion proteins Proteins 0.000 claims 23
- 102000037865 fusion proteins Human genes 0.000 claims 23
- 108090000765 processed proteins & peptides Proteins 0.000 claims 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims 13
- 125000000539 amino acid group Chemical group 0.000 claims 10
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 10
- 230000005945 translocation Effects 0.000 claims 9
- 101001043564 Homo sapiens Prolow-density lipoprotein receptor-related protein 1 Proteins 0.000 claims 8
- 108010066154 Nuclear Export Signals Proteins 0.000 claims 8
- 210000002472 endoplasmic reticulum Anatomy 0.000 claims 7
- 230000014759 maintenance of location Effects 0.000 claims 7
- 230000004927 fusion Effects 0.000 claims 4
- 244000052769 pathogen Species 0.000 claims 4
- 230000001717 pathogenic effect Effects 0.000 claims 4
- 229960005486 vaccine Drugs 0.000 claims 3
- 108700033844 Pseudomonas aeruginosa toxA Proteins 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
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Claims (30)
1. Слитый белок, содержащий:
(a) домен связывания с антигенпрезентирующей клеткой (АПК) или домен связывания с рецептором CD91, расположенный на N-конце слитого белка;
(b) транслокационный пептид длиной от 34 до 112 аминокислотных остатков, содержащий аминокислотную последовательность, которая по меньшей мере на 90% идентична SEQ ID NO: 4, 2, 3 или 6, расположенный на С-конце домена связывания с АПК или домена связывания с рецептором CD91;
(c) антиген патогена, расположенный на С-конце транслокационного пептида;
(d) сигнал ядерного экспорта, содержащий аминокислотную последовательность SEQ ID NO: 13; и
(e) последовательность, обеспечивающую удержание в эндоплазматическом ретикулуме, расположенную на С-конце слитого белка.
2. Слитый белок по п. 1, отличающийся тем, что домен связывания с АПК или домен связывания с CD91 рецептором, является полипептидом, содержащим аминокислотную последовательность, которая по меньшей мере на 90% идентична последовательности, выбранной из группы, состоящей из SEQ ID NO: 1 и с 8 по 11.
3. Слитый белок по п. 1, отличающийся тем, что сигнал ядерного экспорта содержит аминокислотную последовательность SEQ ID NO: 14.
4. Слитый белок по п. 1, отличающийся тем, что последовательность, обеспечивающая удержание в эндоплазматическом ретикулуме, содержит аминокислотную последовательность SEQ ID NO: 15.
5. Слитый белок по п. 1, отличающийся тем, что сигнал ядерного экспорта расположен между транслокационным пептидом и антигеном.
6. Слитый белок по п. 1, отличающийся тем, что сигнал ядерного экспорта расположен между антигеном и последовательностью, обеспечивающей удержание в эндоплазматическом ретикулуме.
7. Слитый белок по п. 1, отличающийся тем, что сигнал ядерного экспорта и последовательность, обеспечивающая удержание в эндоплазматическом ретикулуме, образуют слитый пептид, содержащий аминокислотную последовательность, которая по меньшей мере на 90% идентична SEQ ID NO: 12.
8. Слитый белок по п. 1, отличающийся тем, что транслокационный пептид имеет длину, лежащую в диапазоне от 34 аминокислотных остатков до 61 аминокислотного остатка.
9. Слитый белок по п. 1, отличающийся тем, что домен связывания с АПК или домен связывания с CD91 рецептором не содержит аминокислотной последовательности домена I связывания экзотоксина A Pseudomonas (РЕ).
10. Слитый белок по п. 9, отличающийся тем, что домен связывания с АПК или домен связывания с CD91 рецептором содержит аминокислотную последовательность SEQ ID NO: 8.
11. Слитый белок по п. 1, отличающийся тем, что аминокислотная последовательность домена связывания с АПК или домена связывания с CD91 рецептором является последовательностью SEQ ID NO: 1.
12. Слитый белок по п. 11, отличающийся тем, что транслокационный пептид имеет длину, лежащую в диапазоне от 34 аминокислотных остатков до 61 аминокислотного остатка.
13. Слитый белок по п. 12, отличающийся тем, что сигнал ядерного экспорта и последовательность, обеспечивающая удержания в эндоплазматическом ретикулуме, образуют слитый пептид с аминокислотной последовательностью, которая по меньшей мере на 90% идентична SEQ ID NO: 12.
14. Слитый белок по п. 11, отличающийся тем, что транслокационный пептид имеет длину, лежащую в диапазоне от 34 аминокислотных остатков до 46 аминокислотных остатков.
15. Слитый белок по п. 10, отличающийся тем, что транслокационный пептид имеет длину, лежащую в диапазоне от 34 аминокислотных остатков до 61 аминокислотного остатка.
16. Слитый белок по п. 15, отличающийся тем, что сигнал ядерного экспорта и последовательность, обеспечивающая удержания в эндоплазматическом ретикулуме, образуют слитый пептид с аминокислотной последовательностью, которая по меньшей мере на 90% идентична SEQ ID NO: 12.
17. Слитый белок по п. 1, отличающийся тем, что антиген является слитым антигеном, состоящим из двух или более антигенных пептидов из патогена.
18. Слитый белок по п. 1, отличающийся тем, что он по существу состоит из:
(a) домена связывания с антигенпрезентирующей клеткой (АПК) или домена связывания с рецептором CD91, расположенного на N-конце слитого белка;
(b) транслокационного пептида длиной от 34 до 112 аминокислотных остатков, содержащего аминокислотную последовательность, которая по меньшей мере на 90% идентична SEQ ID NO: 4, 2, 3 или 6, расположенного на С-конце домена связывания с АПК или домена связывания с рецептором CD91;
(c) антигена патогена, расположенного на С-конце транслокационного пептида;
(d) сигнала ядерного экспорта, содержащего аминокислотную последовательность SEQ ID NO: 13; и
(e) последовательности, обеспечивающей удержание в эндоплазматическом ретикулуме, расположенной на С-конце слитого белка.
19. Композиция вакцины, содержащая слитый белок по п. 1 и адъювант.
20. Способ индуцирования усиленных антигенспецифических Т-клеточных ответов против патогена, включающий введение композиции вакцины, содержащей терапевтически эффективное количество композиции вакцины по п. 19, субъекту, нуждающемуся в этом.
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PCT/US2013/072804 WO2014089036A1 (en) | 2012-12-05 | 2013-12-03 | Fusion proteins for use as immunogenic enhancers for inducing antigen-specific t cell responses |
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RU2015122371A RU2631002C2 (ru) | 2012-12-05 | 2013-12-03 | Слитые белки для применения в качестве иммуногенных усиливающих агентов для индуцирования антигенспецифического т-клеточного ответа |
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US11246915B2 (en) | 2010-09-15 | 2022-02-15 | Applied Molecular Transport Inc. | Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo |
CN109553688A (zh) * | 2012-12-05 | 2019-04-02 | 生控基因疫苗股份有限公司 | 用作诱发抗原特异性t细胞反应的免疫原性增强剂的融合蛋白 |
CN107249629A (zh) * | 2015-02-26 | 2017-10-13 | 生控基因疫苗股份有限公司 | 包含免疫原性蛋白质及组合佐剂并用以诱发抗原特异性t细胞反应的疫苗组合物 |
WO2016196383A1 (en) * | 2015-06-01 | 2016-12-08 | Reber Genetics Co., Ltd. | Vaccine compositions against porcine reproductive and respiratory syndrome and porcine circovirus associated diseases |
JP2018521983A (ja) | 2015-07-16 | 2018-08-09 | バイオカイン セラピューティックス リミテッド | がんを治療するための組成物および方法 |
KR102153303B1 (ko) * | 2015-11-23 | 2020-09-09 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | Fmdv 및 e2 융합 단백질 및 이의 용도 |
WO2018052854A1 (en) * | 2016-09-19 | 2018-03-22 | Thevax Genetics Vaccine Co., Ltd. | Hepatitis b therapeutic vaccines |
US11186618B2 (en) * | 2016-09-21 | 2021-11-30 | The Research Foundation For Microbial Diseases Of Osaka University | Dendritic-cell-targeted peptide, fusion peptide utilizing said peptide, and vaccine utilizing said fusion peptide |
CN107991481A (zh) * | 2016-10-27 | 2018-05-04 | 武汉科前生物股份有限公司 | 一种检测猪伪狂犬病毒和口蹄疫病毒的二联阻断elisa抗体检测试剂盒及其应用 |
CN107937354A (zh) * | 2017-11-10 | 2018-04-20 | 南京天邦生物科技有限公司 | 2型猪圆环病毒及其应用 |
PL3762009T3 (pl) | 2018-03-08 | 2022-09-12 | Applied Molecular Transport Inc. | Pochodzące z toksyny konstrukty dostarczające do dostarczania doustnego |
CN109134667A (zh) * | 2018-09-19 | 2019-01-04 | 天康生物股份有限公司 | 融合蛋白及其制备方法、应用、表达系统和疫苗 |
JP2022512976A (ja) | 2018-11-07 | 2022-02-07 | アプライド モレキュラー トランスポート インコーポレイテッド | 異種ペイロードの経口送達のためのコリックス由来担体 |
CN109593136B (zh) * | 2018-12-26 | 2021-03-19 | 天康生物股份有限公司 | 禽副粘病毒融合蛋白及其制备方法、应用和用于鸽子的apmv疫苗 |
KR20220012256A (ko) * | 2019-05-24 | 2022-02-03 | 프로비바 테라퓨틱스 (홍콩) 리미티드 | Il-2 조성물 및 이의 사용 방법 |
CN110051832B (zh) * | 2019-05-31 | 2020-11-10 | 四川农业大学 | 一种犬恶丝虫病疫苗 |
CN110452928A (zh) * | 2019-08-13 | 2019-11-15 | 成都天邦生物制品有限公司 | 一株pk-15稳定细胞株的构建及应用 |
AU2020329290A1 (en) * | 2019-08-13 | 2022-03-24 | Elpis Biopharmaceuticals | Engineered interleukin-2 receptor beta agonists |
CN110669142B (zh) * | 2019-09-30 | 2021-10-12 | 湖南农业大学 | 融合rgd的猪圆环病毒2型病毒样颗粒、突变型感染性克隆及其制备方法和应用 |
US20230173049A1 (en) * | 2019-12-31 | 2023-06-08 | The Johns Hopkins University | Fusion proteins and methods of use thereof |
CN111548395A (zh) * | 2020-05-25 | 2020-08-18 | 中国农业科学院兰州兽医研究所 | 一种口蹄疫病毒二价多表位重组病毒样颗粒及其应用 |
KR102507298B1 (ko) | 2020-12-21 | 2023-03-08 | 충남대학교산학협력단 | 면역증강을 위한 조성물 |
CN112812171B (zh) * | 2021-01-22 | 2022-04-08 | 浙江辉肽生命健康科技有限公司 | 具有氨基酸结构vvrkplnkegkkp的生物活性肽及其制备方法和应用 |
CN114539429B (zh) * | 2022-03-24 | 2022-07-29 | 上海普铭生物科技有限公司 | 融合蛋白组合物及其应用 |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US843505A (en) * | 1905-10-09 | 1907-02-05 | Alexandre Leonard Tombelaine | Safety closing device for miner's lamps. |
PT651805E (pt) * | 1992-07-17 | 2007-02-28 | Dana Farber Cancer Inst Inc | Método de ligação intracelular de moléculas-alvo |
US5712149A (en) * | 1995-02-03 | 1998-01-27 | Cell Genesys, Inc. | Chimeric receptor molecules for delivery of co-stimulatory signals |
US6451592B1 (en) * | 1996-04-05 | 2002-09-17 | Chiron Corporation | Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis |
US20050119470A1 (en) * | 1996-06-06 | 2005-06-02 | Muthiah Manoharan | Conjugated oligomeric compounds and their use in gene modulation |
DE19651443A1 (de) * | 1996-12-11 | 1998-06-18 | Hoechst Ag | Selbstverstärkende, pharmakologisch kontrollierbare Expressionssysteme |
US7314632B1 (en) | 1997-07-11 | 2008-01-01 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Pseudomonas exotoxin A-like chimeric immunogens |
DK1000163T3 (da) * | 1997-07-11 | 2006-02-06 | Us Gov Health & Human Serv | Pseudomonas-exotoksin A-lignende kimære immunogener |
ATE359084T1 (de) * | 1998-02-20 | 2007-05-15 | Univ Miami | Modifizierter hitzeschockprotein/peptidantigen komplex |
WO1999045127A2 (en) * | 1998-03-06 | 1999-09-10 | Oxford Biomedica (Uk) Limited | Enhanced prodrug activation |
US20030215421A1 (en) * | 1999-07-21 | 2003-11-20 | Mcdonald John R. | Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders |
US20020061848A1 (en) * | 2000-07-20 | 2002-05-23 | Ajay Bhatia | Compounds and methods for treatment and diagnosis of chlamydial infection |
WO2000049041A1 (fr) * | 1999-02-19 | 2000-08-24 | Sumitomo Electric Industries, Ltd. | Preparations proteiques |
JP4637368B2 (ja) * | 1999-04-14 | 2011-02-23 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | アルファウイルスに基づくベクター系を利用する免疫応答を生成するための組成物および方法 |
EP1222289B1 (en) * | 1999-10-20 | 2008-04-16 | The Johns Hopkins University School Of Medicine | Chimeric immunogenic compositions and nucleic acids encoding them |
US8128922B2 (en) * | 1999-10-20 | 2012-03-06 | Johns Hopkins University | Superior molecular vaccine linking the translocation domain of a bacterial toxin to an antigen |
US7030219B2 (en) * | 2000-04-28 | 2006-04-18 | Johns Hopkins University | B7-DC, Dendritic cell co-stimulatory molecules |
CA2453528C (en) * | 2001-08-01 | 2011-07-26 | Cellomics, Inc. | Novel fusion proteins and assays for molecular binding |
US7235631B2 (en) * | 2002-02-07 | 2007-06-26 | Mayo Foundation For Medical Education And Research | ICOS mutants |
WO2004087754A1 (en) * | 2003-04-03 | 2004-10-14 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Broad-spectrum in-vivo effective superantigen toxin antagonists based on the interaction between cd28 and the superantigen and uses thereof |
IL164799A0 (en) * | 2002-04-25 | 2005-12-18 | Univ Connecticut | Using heat shock proteins to improve the therapeutic benefit of a non-vaccine treatment modality |
CA2515123A1 (en) * | 2003-02-04 | 2004-08-19 | University Of Connecticut Health Center | Immunogenic cd91 ligand-antigenic molecule complexes and fusion proteins |
EP1594437A2 (en) * | 2003-02-04 | 2005-11-16 | University of Connecticut Health Center | Immunogenic cd91 ligand-antigenic molecule complexes and fusion proteins |
US7595054B2 (en) * | 2003-06-09 | 2009-09-29 | Healthbanks Biotech Co., Ltd. | Fusion antigen used as vaccine |
US7335361B2 (en) | 2003-06-09 | 2008-02-26 | Animal Technology Institute Taiwan | Fusion antigen used as vaccine |
EP1756147A2 (en) * | 2004-06-01 | 2007-02-28 | Innogenetics N.V. | Peptides for inducing a ctl and/or htl response to hepatitis c virus |
JP4474264B2 (ja) * | 2004-08-20 | 2010-06-02 | 生寶生物科技股▲ふん▼有限公司 | 子宮頸癌抑制の融合蛋白 |
WO2006135428A2 (en) * | 2004-10-04 | 2006-12-21 | Trinity Biosystems, Inc. | Methods and compositions for inducing an immune response against multiple antigens |
US7964200B2 (en) * | 2005-05-18 | 2011-06-21 | Children's Hospital & Research Center At Oakland | Methods and compositions for immunizing against Chlamydia infection |
US7465455B2 (en) | 2006-07-05 | 2008-12-16 | Healthbanks Biotech Co., Ltd. | Fusion protein of porcine reproductive and respiratory syndrome virus as PRRS vaccine |
WO2008047243A2 (en) * | 2006-08-29 | 2008-04-24 | Forhumantech. Co., Ltd. | Pharmaceutical composition for suppression of apoptosis and method for delivering the same |
MX2009002893A (es) * | 2006-09-18 | 2009-07-10 | Raptor Pharmaceutical Inc | Tratamiento de trastornos hepaticos mediante la administracion de conjugados de la proteina asociada al receptor (rap). |
US7887801B2 (en) * | 2007-07-13 | 2011-02-15 | Topotarget Germany Ag | Optimized DNA and protein sequence of an antibody to improve quality and yield of bacterially expressed antibody fusion proteins |
WO2009036349A1 (en) * | 2007-09-12 | 2009-03-19 | Anaphore, Inc. | Hsp70-based treatment for autoimmune diseases |
EP2078726A1 (en) * | 2008-01-09 | 2009-07-15 | Vision 7 GmbH | Secretable HIV entry inhibitory peptides for therapy of HIV infection |
CN101969975B (zh) * | 2008-01-31 | 2013-06-05 | 生控基因疫苗股份有限公司 | 作为疫苗的hiv嵌合融合蛋白 |
WO2010040023A2 (en) * | 2008-10-03 | 2010-04-08 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Methods and compositions for protein delivery |
PL391627A1 (pl) * | 2010-06-25 | 2012-01-02 | Adamed Spółka Z Ograniczoną Odpowiedzialnością | Przeciwnowotworowe białko fuzyjne |
CN109553688A (zh) * | 2012-12-05 | 2019-04-02 | 生控基因疫苗股份有限公司 | 用作诱发抗原特异性t细胞反应的免疫原性增强剂的融合蛋白 |
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