BRPI0208183B8 - peptídeo antígeno de câncer modificado por wt1 e vacinas para câncer - Google Patents

peptídeo antígeno de câncer modificado por wt1 e vacinas para câncer

Info

Publication number
BRPI0208183B8
BRPI0208183B8 BRPI0208183A BRPI0208183B8 BR PI0208183 B8 BRPI0208183 B8 BR PI0208183B8 BR PI0208183 A BRPI0208183 A BR PI0208183A BR PI0208183 B8 BRPI0208183 B8 BR PI0208183B8
Authority
BR
Brazil
Prior art keywords
cancer
antigen peptide
modified
peptide
vaccines
Prior art date
Application number
Other languages
English (en)
Inventor
Sugiyama Haruo
Original Assignee
Sugiyama Haruo
Int Inst Cancer Immunology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sugiyama Haruo, Int Inst Cancer Immunology Inc filed Critical Sugiyama Haruo
Publication of BR0208183A publication Critical patent/BR0208183A/pt
Publication of BRPI0208183B1 publication Critical patent/BRPI0208183B1/pt
Publication of BRPI0208183B8 publication Critical patent/BRPI0208183B8/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82Translation products from oncogenes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515Animal cells
    • A61K2039/5154Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515Animal cells
    • A61K2039/5158Antigen-pulsed cells, e.g. T-cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

"peptídeo modificado por wt1". a presente invenção refere-se a um peptídeo de antígeno de câncer compreendendo a seqüência de aminoácido seguinte: cys tyr thr trp asn gln met asn leu (n<0> de id de seqüência 3), uma vacina para câncer tendo isto como seu ingrediente ativo, e uma vacina de dna tendo como seu ingrediente ativo dna que codifica este peptídeo.
BRPI0208183 2001-03-22 2002-03-22 peptídeo antígeno de câncer modificado por wt1 e vacinas para câncer BRPI0208183B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001083250 2001-03-22
PCT/JP2002/002794 WO2002079253A1 (fr) 2001-03-22 2002-03-22 Peptide modifie wt1

Publications (3)

Publication Number Publication Date
BR0208183A BR0208183A (pt) 2004-03-02
BRPI0208183B1 BRPI0208183B1 (pt) 2018-08-28
BRPI0208183B8 true BRPI0208183B8 (pt) 2021-05-25

Family

ID=18939092

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0208183 BRPI0208183B8 (pt) 2001-03-22 2002-03-22 peptídeo antígeno de câncer modificado por wt1 e vacinas para câncer

Country Status (13)

Country Link
US (2) US20040097703A1 (pt)
EP (1) EP1371664B1 (pt)
JP (2) JP3728439B2 (pt)
KR (1) KR100863853B1 (pt)
CN (1) CN1281625C (pt)
AT (1) ATE383375T1 (pt)
BR (1) BRPI0208183B8 (pt)
CA (1) CA2440303C (pt)
DE (1) DE60224508T2 (pt)
ES (1) ES2298353T3 (pt)
HK (1) HK1070078A1 (pt)
TW (1) TWI318630B (pt)
WO (1) WO2002079253A1 (pt)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100767554B1 (ko) 1998-07-31 2007-10-17 인터내셔널 인스티튜트 오브 캔서 이무놀로지 인코퍼레이티드 암 억제 유전자 더블유티1의 생산물에 기초한 암항원
CA2440303C (en) * 2001-03-22 2013-03-19 Haruo Sugiyama Wt1 modified peptide
JPWO2003028758A1 (ja) * 2001-09-28 2005-01-13 治夫 杉山 抗原特異的t細胞の誘導方法
JP5230891B2 (ja) * 2001-09-28 2013-07-10 株式会社癌免疫研究所 抗原特異的t細胞の新規な誘導方法
JP2003243616A (ja) 2002-02-20 2003-08-29 Seiko Epson Corp 半導体装置の製造方法
AU2003242305A1 (en) * 2002-06-12 2003-12-31 Chugai Seiyaku Kabushiki Kaisha Hla-a24-restricted cancer antigen peptide
EP1550453B1 (en) * 2002-09-12 2015-05-27 International Institute of Cancer Immunology, Inc. Cancer antigen peptide preparation
ATE442378T1 (de) * 2002-09-20 2009-09-15 Int Inst Cancer Immunology Inc Substituierte wt1-peptide
CN101851275A (zh) * 2003-01-15 2010-10-06 株式会社国际癌症免疫研究所 二聚体化肽
EP2338509B1 (en) 2003-06-27 2014-06-18 International Institute of Cancer Immunology, Inc. Method of selecting patients suitable for WT1 vaccine
JP4621142B2 (ja) 2003-11-05 2011-01-26 株式会社癌免疫研究所 Wt1由来のhla−dr結合性抗原ペプチド
EP2186896B1 (en) * 2004-03-31 2015-11-04 International Institute of Cancer Immunology, Inc. Cancer antigen peptides derived from WT1
JP2009511637A (ja) 2005-10-17 2009-03-19 スローン−ケターリング インスティチュート フォー キャンサー リサーチ Hlaクラスii結合wt1ペプチド及びその組成物、並びにその作成方法
KR101385805B1 (ko) * 2005-11-30 2014-04-16 인터내셔널 인스티튜트 오브 캔서 이무놀로지 인코퍼레이티드 신규 펩티드 화합물
CN101384716B (zh) * 2006-02-22 2013-03-13 株式会社癌免疫研究所 Hla-a*3303限制性wt1肽和包含此肽的药物组合物
EP3834836A1 (en) 2006-04-10 2021-06-16 Memorial Sloan Kettering Cancer Center Immunogenic wt-1 peptides and uses thereof
US8653038B2 (en) * 2006-12-28 2014-02-18 International Institute Of Cancer Immunology, Inc. HLA-A* 1101-restricted WT1 peptide and pharmaceutical composition comprising the same
KR101598228B1 (ko) 2007-02-27 2016-02-26 인터내셔널 인스티튜트 오브 캔서 이무놀로지 인코퍼레이티드 헬퍼 t 세포의 활성화 방법 및 그를 위한 조성물
EP2857508A3 (en) 2007-03-05 2015-04-15 International Institute of Cancer Immunology, Inc. Cancer antigen-specific T-cell receptor gene, peptide encoded by the gene, and use of them
RU2682726C9 (ru) 2007-12-05 2019-08-15 Интернешнл Инститьют Оф Кэнсер Иммунолоджи, Инк. Вакцинная композиция против злокачественной опухоли
BR112013008230A2 (pt) 2010-10-05 2016-06-14 Int Inst Cancer Immunology Inc método para ativar célula t auxiliar
EP2746393A4 (en) 2011-06-28 2015-06-10 Int Inst Cancer Immunology Inc RECEPTOR GENE FOR A SPECIFIC LYMPHOCYTE OF A CANCER PEPTIDE ANTIGEN
US9539299B2 (en) * 2011-10-27 2017-01-10 International Institute Of Cancer Immunology, Inc. Combination therapy with WT1 peptide vaccine and temozolomide
EP3520810A3 (en) 2012-01-13 2019-11-06 Memorial Sloan-Kettering Cancer Center Immunogenic wt1 peptides and use thereof
US20150150975A1 (en) 2012-07-02 2015-06-04 Sumitomo Dainippon Pharma Co., Ltd. Transdermal cancer antigen peptide preparation
KR20150046346A (ko) 2012-09-12 2015-04-29 인터내셔널 인스티튜트 오브 캔서 이무놀로지 인코퍼레이티드 항원 특이적 헬퍼 t 세포 리셉터 유전자
JP6530192B2 (ja) 2012-12-17 2019-06-12 大塚製薬株式会社 ヘルパーt細胞の活性化方法
US10815273B2 (en) 2013-01-15 2020-10-27 Memorial Sloan Kettering Cancer Center Immunogenic WT-1 peptides and methods of use thereof
AU2014207615B2 (en) 2013-01-15 2018-11-01 Memorial Sloan Kettering Cancer Center Immunogenic WT-1 peptides and methods of use thereof
JP6250288B2 (ja) * 2013-01-30 2017-12-20 株式会社医学生物学研究所 T細胞レセプターおよびその利用
CA2841014A1 (en) 2013-02-05 2014-08-05 Nitto Denko Corporation Tape preparation of wt1 peptide cancer vaccine for transdermal administration
CA2840988A1 (en) 2013-02-05 2014-08-05 Nitto Denko Corporation Wt1 peptide cancer vaccine composition for mucosal administration
RU2687144C2 (ru) 2013-02-05 2019-05-07 Нитто Денко Корпорейшн Композиция противораковой вакцины, содержащей пептид wt1, для трансдермального введения
KR20140100416A (ko) 2013-02-05 2014-08-14 닛토덴코 가부시키가이샤 경피 투여용 wt1 펩티드 암 백신 조성물
ES2694328T3 (es) 2013-03-12 2018-12-19 Sumitomo Dainippon Pharma Co., Ltd. Composición acuosa líquida
WO2014157692A1 (ja) * 2013-03-29 2014-10-02 大日本住友製薬株式会社 Wt1抗原ペプチドコンジュゲートワクチン
EP2980097A4 (en) 2013-03-29 2017-03-08 Sumitomo Dainippon Pharma Co., Ltd. Conjugate vaccine using trimming function of erap1
CA2912514A1 (en) 2013-05-13 2014-11-20 International Institute Of Cancer Immunology, Inc. Method for predicting clinical effect of immunotherapy
US10253075B2 (en) 2014-02-26 2019-04-09 tella, Inc. WT1 antigenic polypeptide, and anti-tumor agent containing said polypeptide
ES2916834T3 (es) 2014-09-27 2022-07-06 Sumitomo Pharma Co Ltd Composición farmacéutica para inyección
EP3549957A4 (en) 2016-11-30 2020-08-05 Sumitomo Dainippon Pharma Co., Ltd. WT1-HELPER PEPTIDE AND COMBINATION OF THE SAYING PEPTIDE AND A CANCER ANTIGEN PEPTIDE CONJUGATE
WO2018181648A1 (ja) 2017-03-30 2018-10-04 大日本住友製薬株式会社 Wt1癌抗原ペプチドおよびこれを含むペプチドコンジュゲート体
US20210338587A1 (en) 2018-09-28 2021-11-04 Sumitomo Dainippon Pharma Co., Ltd. Injectable composition
WO2020071551A1 (ja) 2018-10-05 2020-04-09 株式会社癌免疫研究所 良性腫瘍の予防または治療薬
TW202045528A (zh) 2019-02-28 2020-12-16 日商大日本住友製藥股份有限公司 選擇可期待用於治療或預防癌之醫藥組合物之效果之對象之方法
EP4151227A1 (en) 2020-05-12 2023-03-22 Sumitomo Pharma Co., Ltd. Pharmaceutical composition for treating cancer
CN111647066B (zh) * 2020-07-01 2020-12-18 维肽瀛(上海)生物技术有限公司 Wt1多肽肿瘤抑制剂
TW202315645A (zh) 2021-08-12 2023-04-16 日商癌免疫研究所股份有限公司 用以處置或預防癌症之醫藥組合物及方法

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6122018A (ja) 1984-07-06 1986-01-30 Green Cross Corp:The 癌免疫療法増強剤
WO1991007509A1 (en) 1989-11-13 1991-05-30 Massachusetts Institute Of Technology Localization and characterization of the wilms's tumor gene
JPH09506866A (ja) 1993-12-14 1997-07-08 ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン 医薬として活性のある物質の免疫療法のための放出制御
US5622835A (en) 1994-04-28 1997-04-22 The Wistar Institute Of Anatomy & Biology WT1 monoclonal antibodies
AU713040B2 (en) 1994-07-15 1999-11-18 University Of Iowa Research Foundation, The Immunomodulatory oligonucleotides
JP3904260B2 (ja) 1995-06-01 2007-04-11 岸本 忠三 ウイルムス腫瘍遺伝子(wt1)に対するアンチセンスオリゴヌクレオチド誘導体を含んで成る白血病細胞増殖阻害剤
ATE332710T1 (de) * 1995-06-01 2006-08-15 Kishimoto Tadamitsu Wachstumsinhibitor gegen leukämische zellen, der antisense-oligonukleotidderivate gegen das wilms- tumorgen enthält
DE59611501D1 (de) * 1995-09-19 2009-12-24 Bayer Bioscience Gmbh Verfahren zur Herstellung einer modifizierten Stärke
US20030092656A1 (en) * 1997-07-16 2003-05-15 Haruo Sugiyama Therapeutic agents for treatment of solid tumors comprising an expression-inhibiting sustance against Wilms' tumor gene (WT1)
JP4789095B2 (ja) 1997-07-16 2011-10-05 治夫 杉山 ウイルムス腫瘍遺伝子(wt1)に対する発現阻害物質を含んで成る固形腫瘍治療剤
US5985264A (en) 1998-03-05 1999-11-16 The Medical College Of Ohio IL-12 Stimulation of Neonatal immunity
KR100767554B1 (ko) 1998-07-31 2007-10-17 인터내셔널 인스티튜트 오브 캔서 이무놀로지 인코퍼레이티드 암 억제 유전자 더블유티1의 생산물에 기초한 암항원
US7655249B2 (en) * 1998-09-30 2010-02-02 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US20030039635A1 (en) * 1998-09-30 2003-02-27 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US20030235557A1 (en) * 1998-09-30 2003-12-25 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US20030215458A1 (en) * 1998-09-30 2003-11-20 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US20030072767A1 (en) * 1998-09-30 2003-04-17 Alexander Gaiger Compositions and methods for WT1 specific immunotherapy
IL142216A0 (en) * 1998-09-30 2002-03-10 Corixa Corp A polypeptide containing an immunogenic portion of a native wti and pharmaceutical compositions containing the same
US7144581B2 (en) * 2000-10-09 2006-12-05 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US7901693B2 (en) * 1998-09-30 2011-03-08 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
GB9823897D0 (en) * 1998-11-02 1998-12-30 Imp College Innovations Ltd Immunotherapeutic methods and molecules
HUP0105070A2 (hu) 1999-01-12 2002-04-29 Smithkline Beecham Biologicals S.A. Hepatitis B vírus fertőzések megelőzésére és kezelésére szolgáló készlet
EP1031346B1 (en) 1999-01-27 2002-05-02 Idea Ag Noninvasive vaccination through the skin
ATE320266T1 (de) 1999-07-22 2006-04-15 Dainippon Sumitomo Pharma Co Induktion von antigen-spezifischen t-zellen durch interferon
JP2001089389A (ja) 1999-07-22 2001-04-03 Sumitomo Pharmaceut Co Ltd 抗原特異的t細胞の誘導剤
EP1261711A2 (en) 2000-02-22 2002-12-04 Corixa Corporation Compositions and methods for diagnosis and therapy of malignant mesothelioma
CA2440303C (en) 2001-03-22 2013-03-19 Haruo Sugiyama Wt1 modified peptide
US7553494B2 (en) * 2001-08-24 2009-06-30 Corixa Corporation WT1 fusion proteins
JPWO2003028758A1 (ja) * 2001-09-28 2005-01-13 治夫 杉山 抗原特異的t細胞の誘導方法
JP5230891B2 (ja) * 2001-09-28 2013-07-10 株式会社癌免疫研究所 抗原特異的t細胞の新規な誘導方法
AU2003242305A1 (en) 2002-06-12 2003-12-31 Chugai Seiyaku Kabushiki Kaisha Hla-a24-restricted cancer antigen peptide
EP1550453B1 (en) 2002-09-12 2015-05-27 International Institute of Cancer Immunology, Inc. Cancer antigen peptide preparation
ATE442378T1 (de) 2002-09-20 2009-09-15 Int Inst Cancer Immunology Inc Substituierte wt1-peptide
CN101851275A (zh) 2003-01-15 2010-10-06 株式会社国际癌症免疫研究所 二聚体化肽
EP2338509B1 (en) 2003-06-27 2014-06-18 International Institute of Cancer Immunology, Inc. Method of selecting patients suitable for WT1 vaccine
JP4621142B2 (ja) 2003-11-05 2011-01-26 株式会社癌免疫研究所 Wt1由来のhla−dr結合性抗原ペプチド
EP2186896B1 (en) 2004-03-31 2015-11-04 International Institute of Cancer Immunology, Inc. Cancer antigen peptides derived from WT1

Also Published As

Publication number Publication date
ATE383375T1 (de) 2008-01-15
EP1371664A4 (en) 2006-03-22
JP3728439B2 (ja) 2005-12-21
KR100863853B1 (ko) 2008-10-15
TWI318630B (en) 2009-12-21
ES2298353T3 (es) 2008-05-16
EP1371664B1 (en) 2008-01-09
KR20030084970A (ko) 2003-11-01
DE60224508D1 (de) 2008-02-21
BR0208183A (pt) 2004-03-02
JPWO2002079253A1 (ja) 2004-07-22
CA2440303A1 (en) 2002-10-10
CA2440303C (en) 2013-03-19
WO2002079253A1 (fr) 2002-10-10
EP1371664A1 (en) 2003-12-17
US8105604B2 (en) 2012-01-31
US20090325886A1 (en) 2009-12-31
US20040097703A1 (en) 2004-05-20
HK1070078A1 (en) 2005-06-10
CN1281625C (zh) 2006-10-25
BRPI0208183B1 (pt) 2018-08-28
JP2006034296A (ja) 2006-02-09
DE60224508T2 (de) 2008-12-24
CN1531553A (zh) 2004-09-22
JP3819930B2 (ja) 2006-09-13

Similar Documents

Publication Publication Date Title
BRPI0208183B8 (pt) peptídeo antígeno de câncer modificado por wt1 e vacinas para câncer
MXPA05009580A (es) Vacuna contra el virus de la influenza.
TW200602071A (en) Methods for preventing and treating alzheimer&#39;s disease (ad)
BR0208636A (pt) Agente terapêutico para doenças de artrìtides crÈnicas de doenças relacionadas com inf‰ncia
BR0114393A (pt) Uso de uma preparação de vìrus envelopado dividido, método para produzir uma formulação de vacina intranasal, uso de uma preparação de vacina de vìrus envolopado dividido, kit para liberação de uma formulação de vacina intranasal, dispositivo de liberação intranasal, e, método para proteger ou tratar um mamìfero susceptìvel a, ou sofrendo de doença causada por vìrus envelopado
BRPI0815578B8 (pt) peptídeos, agentes farmacêuticos compreendendo os mesmos, métodos in vitro para induzir uma célula apresentadora de antígeno, usos dos referidos peptídeos, e vacina
ES2069435T4 (es) Composicion de vacuna para vacunar animales, en concreto mamiferos y mas concretamente cerdos o cochinos.
BR0007597A (pt) Composição hipoalergênica contendo peptìdios tolerogênicos induzindo tolerância oral
CY1107146T1 (el) Μεθοδοι για προληψη και θεραπεια ασθενειας alzheimer (ad)
BR0014281A (pt) Vacina contra vìrus de gripe intranasal
BR0016022A (pt) Vacina para a prevenção e tratamento da doença de alzheimer e doenças relacionadas ao amilóide
BR0209434A (pt) Peptìdeos antimicrobianos e composições
BRPI0514411B8 (pt) formulação, e, método de produzir uma formulação
NZ592713A (en) Adjuvanted influenza vaccines including a cytokine-inducing agents other than an agonist of Toll-Like Receptor 9
BR0211296A (pt) Peptìdeo imunogênico derivado da proteìna g do vrs do sub-grupo a ou b, sequência de ácido nucleico, composição farmacêutica, anticorpos policlonais ou monoclonais, kit de diagnóstico, utilização de um peptìdeo imunogênico, e, conjugado
CY1114614T1 (el) Αντιγονα αιμοφιλου ινφλουεντσας και αντιστοιχα dna θραυσματα
BR9811094A (pt) Agente terapêutico para tumores linfáticos
ES2538486T3 (es) Preparación de péptidos antigénicos contra el cáncer
BR0012919A (pt) Vacina para uso na profilaxia e/ou no tratamento da sìndrome de ponto branco (white spot syndrome) em crustáceos, proteìna estrutural derivada do vìrus da sìndrome de ponto branco, sequência de ácido nucléico, uso de uma proteìna estrutural, composição farmacêutica, anticorpos, vacina ou formulação farmacêutica, e, kit diagnóstico para detecção de wssv
WO2003035695A3 (en) Agents that activate or inhibit toll-like receptor 9
ECSP024257A (es) Proteinas antigenas del virus de la enfermedad de la mancha blanca en el camaron y usos de las mismas
BR0009472A (pt) Antagonistas de lhrh com propriedades desolubilidade aperfeiçoadas
ES2422081T3 (es) Péptido Ser-Ser-Ser-Arg y sus utilizaciones medicinales
BR0214363A (pt) Anticorpo, uso de um anticorpo, medicamento, método de fabricação de um medicamento e pacote farmacêutico para o tratamento de infecção
ATE205219T1 (de) Ein verbessertes peptid, immunogene zusammensetzung und impfstoff oder medizinische präparate, eine methode zur immunisierung von tieren gegen das hormon lhrh und analoge des lhrh-tendem-repeat-peptid und deren verwendung als impfstoff

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: INTERNATIONAL INSTITUTE OF CANCER IMMUNOLOGY, INC.

Free format text: TRANSFERIDO DE: HARUO SUGIYAMA

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Ipc: C07K 14/47 (2006.01), A61K 39/00 (2006.01), A61P 3

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 28/08/2018, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 22/03/2002 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 21A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2715 DE 17-01-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.