BR0016022A - Vacina para a prevenção e tratamento da doença de alzheimer e doenças relacionadas ao amilóide - Google Patents
Vacina para a prevenção e tratamento da doença de alzheimer e doenças relacionadas ao amilóideInfo
- Publication number
- BR0016022A BR0016022A BR0016022-9A BR0016022A BR0016022A BR 0016022 A BR0016022 A BR 0016022A BR 0016022 A BR0016022 A BR 0016022A BR 0016022 A BR0016022 A BR 0016022A
- Authority
- BR
- Brazil
- Prior art keywords
- alzheimer
- disease
- prevention
- treatment
- vaccine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0007—Nervous system antigens; Prions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Abstract
"VACINA PARA A PREVENçãO E TRATAMENTO DA DOENçA DE ALZHEIMER E DOENçAS RELACIONADAS AO AMILóIDE". A presente invenção está relacionada estereoquimicamente a uma vacina com base no antígeno "sintético" para a prevenção e/ou tratamento da doença de Alzheimer e outras doenças relacionadas ao amilóide. A presente invenção fornece uma vacina para a prevenção e tratamento da doença de Alzheimer e outras doenças relacionadas ao amielóide, que supera as desvantagens associadas com o uso de peptídeos, proteínas ou imunogenes naturais.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16859499P | 1999-11-29 | 1999-11-29 | |
US72484200A | 2000-11-28 | 2000-11-28 | |
PCT/CA2000/001413 WO2001039796A2 (en) | 1999-11-29 | 2000-11-29 | Vaccine for the prevention and treatment of alzheimer's and amyloid related diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0016022A true BR0016022A (pt) | 2002-08-06 |
Family
ID=26864284
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0016022-9A BR0016022A (pt) | 1999-11-29 | 2000-11-29 | Vacina para a prevenção e tratamento da doença de alzheimer e doenças relacionadas ao amilóide |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP1235587A2 (pt) |
JP (1) | JP2004500354A (pt) |
KR (2) | KR20020073341A (pt) |
CN (1) | CN1433321A (pt) |
AU (1) | AU784312B2 (pt) |
BR (1) | BR0016022A (pt) |
CA (1) | CA2388559A1 (pt) |
HK (1) | HK1049279A1 (pt) |
IL (1) | IL149924A0 (pt) |
MX (1) | MXPA02005576A (pt) |
NO (1) | NO20022531L (pt) |
NZ (1) | NZ540564A (pt) |
WO (1) | WO2001039796A2 (pt) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU1072897A (en) | 1995-12-12 | 1997-07-03 | Karolinska Innovations Ab | Peptide binding the klvff-sequence of amyloid beta |
US6743427B1 (en) | 1997-12-02 | 2004-06-01 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US6761888B1 (en) | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
US6750324B1 (en) | 1997-12-02 | 2004-06-15 | Neuralab Limited | Humanized and chimeric N-terminal amyloid beta-antibodies |
US6787523B1 (en) | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
US20030147882A1 (en) | 1998-05-21 | 2003-08-07 | Alan Solomon | Methods for amyloid removal using anti-amyloid antibodies |
US6787637B1 (en) | 1999-05-28 | 2004-09-07 | Neuralab Limited | N-Terminal amyloid-β antibodies |
UA81216C2 (en) | 1999-06-01 | 2007-12-25 | Prevention and treatment of amyloid disease | |
US20020094335A1 (en) * | 1999-11-29 | 2002-07-18 | Robert Chalifour | Vaccine for the prevention and treatment of alzheimer's and amyloid related diseases |
CZ20022748A3 (cs) * | 2000-02-21 | 2004-03-17 | Pharmexa A/S | Nová metoda regulace obsahu amyloidu |
AU2007200047B2 (en) * | 2000-07-07 | 2009-11-26 | Bioarctic Neuroscience Ab | Prevention and treatment of Alzheimer's disease |
JP5362164B2 (ja) | 2000-07-07 | 2013-12-11 | バイオアークティック ニューロサイエンス アーベー | アルツハイマー病の予防及び治療 |
US20020115717A1 (en) * | 2000-07-25 | 2002-08-22 | Francine Gervais | Amyloid targeting imaging agents and uses thereof |
US7311893B2 (en) | 2000-07-25 | 2007-12-25 | Neurochem (International) Limited | Amyloid targeting imaging agents and uses thereof |
US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
MY144532A (en) | 2001-08-20 | 2011-09-30 | Lundbeck & Co As H | Novel method for down-regulation of amyloid |
AR038568A1 (es) | 2002-02-20 | 2005-01-19 | Hoffmann La Roche | Anticuerpos anti-a beta y su uso |
MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
CA2491611A1 (en) | 2002-07-03 | 2004-01-15 | Bio Science International, Inc. | Peptides comprising aromatic d-amino acids and methods of use |
DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
US8663650B2 (en) | 2003-02-21 | 2014-03-04 | Ac Immune Sa | Methods and compositions comprising supramolecular constructs |
TWI306458B (en) | 2003-05-30 | 2009-02-21 | Elan Pharma Int Ltd | Humanized antibodies that recognize beta amyloid peptide |
UA96115C2 (uk) * | 2003-06-23 | 2011-10-10 | Беллас Хелс (Інтернешнл) Лімітед | Спосіб і композиція для лікування амілоїдогенних захворювань |
TWI379839B (en) * | 2003-12-17 | 2012-12-21 | Wyeth Llc | Aβ immunogenic peptide carrier conjugates and methods of producing same |
SE0401601D0 (sv) | 2004-06-21 | 2004-06-21 | Bioarctic Neuroscience Ab | Protofibril specific antibodies and uses thereof |
US8916165B2 (en) | 2004-12-15 | 2014-12-23 | Janssen Alzheimer Immunotherapy | Humanized Aβ antibodies for use in improving cognition |
EP1836161B1 (en) | 2004-12-22 | 2016-07-20 | BHI Limited Partnership | Methods and compositions for treating amyloid-related diseases |
KR100851035B1 (ko) | 2005-08-23 | 2008-08-11 | 대한민국 | GCP-Ⅱ를 유효성분으로 함유하는 β-아밀로이드의 뇌내축적 예방 및 치료용 약학적 조성물과 치료제 스크리닝용조성물 및 이를 이용한 스크리닝 방법 |
KR20080095836A (ko) | 2005-11-10 | 2008-10-29 | 로스캄프 리서치 엘엘씨 | A―베타 펩티드 단편에 의한 혈관형성의 조정 |
ES2527661T3 (es) | 2005-11-30 | 2015-01-28 | Abbvie Inc. | Método de exploración, proceso para purificar oligómeros Abeta no difundibles, anticuerpos selectivos contra dichos oligómeros Abeta no difundibles y un proceso para fabricar dichos anticuerpos |
AU2006320392B2 (en) | 2005-11-30 | 2013-01-17 | AbbVie Deutschland GmbH & Co. KG | Monoclonal antibodies against amyloid beta protein and uses thereof |
MY181173A (en) * | 2005-12-12 | 2020-12-21 | Ac Immune Sa | Therapeutic vaccine |
NZ568241A (en) | 2005-12-12 | 2011-08-26 | Hoffmann La Roche | Antibodies against amyloid beta 4 with glycosylation in the variable region |
NZ567888A (en) | 2006-03-23 | 2010-08-27 | Bioarctic Neuroscience Ab | Improved protofibril selective antibodies and the use thereof |
WO2009017467A1 (en) | 2007-07-27 | 2009-02-05 | Elan Pharma International Limited | Treatment of amyloidogenic diseases |
US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
CA2657681C (en) | 2006-07-14 | 2019-03-19 | Ac Immune S.A. | Humanized antibodies against beta amyloid protein |
ME01758B (me) * | 2006-07-14 | 2014-09-20 | Genentech Inc | Humanizirano protutijelo protiv amiloida beta |
PL2074145T3 (pl) * | 2006-10-02 | 2017-11-30 | Ac Immune S.A. | Humanizowane przeciwciało przeciw amyloidowi beta |
PL2089417T3 (pl) | 2006-10-12 | 2015-07-31 | Bhi Lp | Sposoby, związki, kompozycje i nośniki dostarczające kwas 3-amino-1-propanosulfonowy |
US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
US20100311767A1 (en) | 2007-02-27 | 2010-12-09 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
US8003097B2 (en) | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
EP2149584B1 (en) * | 2007-04-20 | 2017-12-13 | The Chemo-Sero-Therapeutic Research Institute | Method for enhancing immune response with peptide |
JP2010528583A (ja) * | 2007-06-11 | 2010-08-26 | エーシー イミューン ソシエテ アノニム | アミロイドβに対するヒト化抗体 |
US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
RS53174B (en) | 2007-10-05 | 2014-06-30 | Genentech Inc. | USE OF ANTIAMYLOID BETA ANTIBODY IN THE EVENT OF ANY DISEASE |
JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
WO2009143489A2 (en) * | 2008-05-22 | 2009-11-26 | Archer Pharmaceuticals, Inc. | Modulation of angiogenesis by a-beta peptide fragments |
US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
EP2273273A1 (en) * | 2009-07-11 | 2011-01-12 | Rheinische Friedrich-Wilhelms-Universität Bonn | Inhibitors of the nitration of amyloid ß peptides and their uses in the diagnosis and treatment of alzheimer's disease |
EP2558494B1 (en) | 2010-04-15 | 2018-05-23 | AbbVie Inc. | Amyloid-beta binding proteins |
WO2012016173A2 (en) | 2010-07-30 | 2012-02-02 | Ac Immune S.A. | Safe and functional humanized antibodies |
MX358739B (es) | 2010-08-14 | 2018-09-03 | Abbvie Inc Star | Proteinas de union a amiloide beta. |
DK3166970T3 (da) | 2014-07-10 | 2021-05-25 | Bioarctic Ab | FORBEDREDE Aß-PROTOFIBRILBINDENDE ANTISTOFFER |
PL3313879T3 (pl) | 2015-06-24 | 2022-04-11 | F. Hoffmann-La Roche Ag | Przeciwciała przeciwko receptorowi transferyny z dostosowanym powinowactwem |
MX2018003822A (es) | 2015-10-02 | 2018-06-22 | Hoffmann La Roche | Anticuerpos biespecificos contra el cd20 humano y el receptor de transferrina humano y metodos de uso. |
AR106189A1 (es) | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO |
AU2016354688B2 (en) | 2015-11-09 | 2021-12-16 | The University Of British Columbia | Epitopes in Amyloid beta mid-region and conformationally-selective antibodies thereto |
CA3004498A1 (en) | 2015-11-09 | 2017-05-18 | Neil R. Cashman | Amyloid beta epitopes and antibodies thereto |
US20180125920A1 (en) | 2016-11-09 | 2018-05-10 | The University Of British Columbia | Methods for preventing and treating A-beta oligomer-associated and/or -induced diseases and conditions |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0929574T3 (da) * | 1996-08-27 | 2005-10-31 | Praecis Pharm Inc | Modulatorer af beta-amyloidpeptidaggregering, som omfatter D-aminosyrer |
NO314086B1 (no) * | 1998-05-08 | 2003-01-27 | Gemvax As | Peptider og farmasöytiske sammensetninger inneholdende disse, nukleinsyresekvenser som koder for slike peptider, plasmider og virusvektoreromfattende slike DNA-sekvenser samt anvendelse av disse for fremstilling avfarmasöytiske preparater til |
WO2000068263A2 (en) * | 1999-05-05 | 2000-11-16 | Neurochem, Inc. | Stereoselective antifibrillogenic peptides and peptidomimetics thereof |
-
2000
- 2000-11-29 AU AU18473/01A patent/AU784312B2/en not_active Ceased
- 2000-11-29 MX MXPA02005576A patent/MXPA02005576A/es not_active Application Discontinuation
- 2000-11-29 CN CN00816414A patent/CN1433321A/zh active Pending
- 2000-11-29 KR KR1020027006845A patent/KR20020073341A/ko not_active Application Discontinuation
- 2000-11-29 CA CA002388559A patent/CA2388559A1/en not_active Abandoned
- 2000-11-29 BR BR0016022-9A patent/BR0016022A/pt not_active Application Discontinuation
- 2000-11-29 NZ NZ540564A patent/NZ540564A/en unknown
- 2000-11-29 WO PCT/CA2000/001413 patent/WO2001039796A2/en active Application Filing
- 2000-11-29 KR KR1020087013848A patent/KR20080059676A/ko not_active Application Discontinuation
- 2000-11-29 JP JP2001541528A patent/JP2004500354A/ja active Pending
- 2000-11-29 EP EP00981111A patent/EP1235587A2/en not_active Withdrawn
- 2000-11-29 IL IL14992400A patent/IL149924A0/xx unknown
-
2002
- 2002-05-28 NO NO20022531A patent/NO20022531L/no not_active Application Discontinuation
-
2003
- 2003-01-16 HK HK03100407.4A patent/HK1049279A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
WO2001039796A2 (en) | 2001-06-07 |
HK1049279A1 (zh) | 2003-05-09 |
MXPA02005576A (es) | 2002-12-13 |
NO20022531D0 (no) | 2002-05-28 |
JP2004500354A (ja) | 2004-01-08 |
WO2001039796A3 (en) | 2001-12-06 |
KR20080059676A (ko) | 2008-06-30 |
CA2388559A1 (en) | 2001-06-07 |
NO20022531L (no) | 2002-07-12 |
CN1433321A (zh) | 2003-07-30 |
AU1847301A (en) | 2001-06-12 |
AU784312B2 (en) | 2006-03-09 |
EP1235587A2 (en) | 2002-09-04 |
KR20020073341A (ko) | 2002-09-23 |
NZ540564A (en) | 2007-04-27 |
IL149924A0 (en) | 2002-11-10 |
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Legal Events
Date | Code | Title | Description |
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B25A | Requested transfer of rights approved |
Owner name: NEUROCHEM (INTERNATIONAL) LIMITED (CH) Free format text: TRANSFERIDO DE: NEUROCHEM INC. |
|
B25G | Requested change of headquarter approved |
Owner name: NEUROCHEM (INTERNATIONAL) LIMITED (CH) Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020050045770/RJ DE 03/06/2005. |
|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
B11T | Dismissal of application maintained [chapter 11.20 patent gazette] |