CY1110634T1 - Μεθοδοι προληψης και θεραπειας της νοσου του αλτσχαϊμερ (ad) - Google Patents
Μεθοδοι προληψης και θεραπειας της νοσου του αλτσχαϊμερ (ad)Info
- Publication number
- CY1110634T1 CY1110634T1 CY20101100399T CY101100399T CY1110634T1 CY 1110634 T1 CY1110634 T1 CY 1110634T1 CY 20101100399 T CY20101100399 T CY 20101100399T CY 101100399 T CY101100399 T CY 101100399T CY 1110634 T1 CY1110634 T1 CY 1110634T1
- Authority
- CY
- Cyprus
- Prior art keywords
- amino acid
- except
- alzheimer
- disease
- prevention
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Neurology (AREA)
- Toxicology (AREA)
- Neurosurgery (AREA)
- Marine Sciences & Fisheries (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Abstract
Η εφεύρεση σχετίζεται με τη χρήση ένωσης που περιλαμβάνει την παρακάτω αμινοξική ακολουθία Χ1Χ2Χ3Χ4Χ5Χ6, όπου το Χ1 είναι αμινοξύ, εκτός C, όπου το Χ2 είναι αμινοξύ, εκτός C, όπου το Χ3 είναι αμινοξύ, εκτός C, όπου το Χ4 είναι αμινοξύ, εκτός C, όπου το Χ5 είναι αμινοξύ, εκτός C, όπου το Χ6 είναι αμινοξύ, εκτός C, και όπου το Χ1Χ2Χ3Χ4Χ5Χ6 δεν είναι DAEFRH, με την εν λόγω ένωση να διαθέτει ικανότητα δέσμευσης σε αντίσωμα που είναι ειδικό για τη φυσική αμινοτελική ακολουθία Αβ42 DAEFRH, και της οποίας τα πενταμερή διαθέτουν ικανότητα δέσμευσης στο εν λόγω αντίσωμα που είναι ειδικό για τη φυσική αμινοτελική ακολουθία Αβ42 DAEFRH, για την παρασκευή εμβολίου για τη νόσο του Αλτσχάιμερ.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT362003 | 2003-01-14 | ||
AT0146403A AT413945B (de) | 2003-01-14 | 2003-09-17 | Impfstoff für die alzheimer-krankheit |
EP04701585A EP1583774B1 (en) | 2003-01-14 | 2004-01-13 | Methods for preventing and treating alzheimer's disease (ad) |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1110634T1 true CY1110634T1 (el) | 2015-04-29 |
Family
ID=32714004
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20081100069T CY1107146T1 (el) | 2003-01-14 | 2008-01-17 | Μεθοδοι για προληψη και θεραπεια ασθενειας alzheimer (ad) |
CY20101100399T CY1110634T1 (el) | 2003-01-14 | 2010-05-07 | Μεθοδοι προληψης και θεραπειας της νοσου του αλτσχαϊμερ (ad) |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20081100069T CY1107146T1 (el) | 2003-01-14 | 2008-01-17 | Μεθοδοι για προληψη και θεραπεια ασθενειας alzheimer (ad) |
Country Status (15)
Country | Link |
---|---|
US (2) | US7732568B2 (el) |
EP (2) | EP1583774B1 (el) |
JP (2) | JP4547373B2 (el) |
CN (2) | CN1826354B (el) |
AT (3) | AT413945B (el) |
CA (1) | CA2513218C (el) |
CY (2) | CY1107146T1 (el) |
DE (2) | DE602004025668D1 (el) |
DK (2) | DK1679319T3 (el) |
ES (2) | ES2296084T3 (el) |
HK (1) | HK1091499A1 (el) |
PL (1) | PL209989B1 (el) |
PT (2) | PT1583774E (el) |
SI (1) | SI1583774T1 (el) |
WO (1) | WO2004062556A2 (el) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003303198A1 (en) | 2002-12-19 | 2004-07-14 | New York University | Method for treating amyloid disease |
DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
AT413336B (de) * | 2003-09-12 | 2006-02-15 | Mattner Frank Dr | Apherese-vorrichtung |
JP2007522119A (ja) * | 2004-01-28 | 2007-08-09 | キュリックス エーピーエス | アミロイド関連疾患用ワクチンとしてのアミロイドタンパク質のコンジュゲート |
AT500483B1 (de) | 2004-07-13 | 2006-01-15 | Mattner Frank Dr | Set zur vorbeugung oder behandlung der alzheimer'schen erkrankung |
AT413946B (de) * | 2004-07-13 | 2006-07-15 | Mattner Frank Dr | Impfstoff gegen die alzheimer-krankheit |
PT1954718E (pt) | 2005-11-30 | 2014-12-16 | Abbvie Inc | Anticorpos anti-globulómeros aβ, suas porções de ligação ao antigénio, correspondentes hibridomas, ácidos nucleicos, vectores, células hospedeiras, métodos de produção dos ditos anticorpos, composições compreendendo os ditos anticorpos, usos dos ditos anticorpos e métodos para uso dos ditos anticorpos |
DK1976877T4 (en) | 2005-11-30 | 2017-01-16 | Abbvie Inc | Monoclonal antibodies to amyloid beta protein and uses thereof |
KR20150098683A (ko) * | 2005-12-12 | 2015-08-28 | 에이씨 이뮨 에스.에이. | 치료적 특성을 갖는 베타 1-42 특이적인 단일클론성 항체 |
EP1878747A1 (en) | 2006-07-11 | 2008-01-16 | greenovation Biotech GmbH | Glyco-engineered antibodies |
SG173385A1 (en) | 2006-07-14 | 2011-08-29 | Ac Immune S A Ch | Humanized antibody against amyloid beta |
US8455626B2 (en) * | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
WO2008104386A2 (en) | 2007-02-27 | 2008-09-04 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
RU2567151C2 (ru) * | 2007-06-12 | 2015-11-10 | Ац Иммуне С.А. | Гуманизированные антитела к амилоиду бета |
US8048420B2 (en) * | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
AU2008311367B2 (en) * | 2007-10-05 | 2014-11-13 | Ac Immune S.A. | Use of anti-amyloid beta antibody in ocular diseases |
AU2008311366B2 (en) * | 2007-10-05 | 2015-03-12 | Ac Immune S.A. | Use of anti-amyloid beta antibody in ocular diseases |
SG185277A1 (en) * | 2007-10-05 | 2012-11-29 | Genentech Inc | Humanized antibody |
US8586706B2 (en) * | 2007-10-25 | 2013-11-19 | Kagoshima University | Peptide vaccine using mimic molecules of amyloid β peptide |
US8445649B2 (en) * | 2007-10-29 | 2013-05-21 | Tao Health Life Pharma Co., Ltd. | Antibody and use thereof |
US8546532B2 (en) | 2008-04-17 | 2013-10-01 | Declion Pharmaceuticals, Inc. | Synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders |
KR20110036809A (ko) * | 2008-06-12 | 2011-04-11 | 아피리스 아게 | 파킨슨병과 관련된 증상을 치료하기 위한 화합물 |
AT509611B1 (de) * | 2008-06-12 | 2012-04-15 | Affiris Forschungs-Und Entwicklungs Gmbh | Vakzin |
AT506819B1 (de) * | 2008-06-12 | 2011-06-15 | Affiris Forschungs Und Entwicklungs Gmbh | Vakzin zur behandlung von alzheimer-krankheit |
MX360403B (es) | 2010-04-15 | 2018-10-31 | Abbvie Inc | Proteinas de union a amiloide beta. |
CN103179981B (zh) | 2010-07-30 | 2017-02-08 | Ac免疫有限公司 | 安全和功能性的人源化抗β‑淀粉样蛋白抗体 |
EP2603524A1 (en) | 2010-08-14 | 2013-06-19 | AbbVie Inc. | Amyloid-beta binding proteins |
US20120328605A1 (en) * | 2010-10-27 | 2012-12-27 | Daniel Larocque | Compositions and uses |
GB201113570D0 (en) * | 2011-08-05 | 2011-09-21 | Glaxosmithkline Biolog Sa | Vaccine |
PT2579042E (pt) | 2011-10-04 | 2014-09-09 | Affiris Ag | Método para detecção de anticorpos específicos para a numa amostra biológica. |
EP2787347A1 (en) | 2013-04-03 | 2014-10-08 | Affiris AG | Method for detecting Aß-specific antibodies in a biological sample |
US10381614B2 (en) * | 2013-04-17 | 2019-08-13 | Samsung Sdi Co., Ltd. | Battery module |
WO2015165961A1 (en) | 2014-04-29 | 2015-11-05 | Affiris Ag | Treatment and prevention of alzheimer's disease (ad) |
WO2017076873A1 (en) | 2015-11-03 | 2017-05-11 | Affiris Ag | Method for vaccination against a self-antigen in a human patient |
CN105237628B (zh) * | 2015-11-17 | 2018-08-07 | 南开大学 | 一种用于治疗阿尔兹海默症的多肽 |
CN107022019B (zh) * | 2016-11-24 | 2020-10-30 | 桂林医学院 | 一种用于脑内降铁除自由基的多肽、制备方法与应用 |
WO2023161526A1 (en) | 2022-02-28 | 2023-08-31 | Tridem Bioscience Gmbh & Co Kg | A CONJUGATE CONSISTING OF OR COMPRISING AT LEAST A ß-GLUCAN OR A MANNAN |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK590288D0 (da) * | 1988-10-24 | 1988-10-24 | Symbicom Ab | Kemiske forbindelser |
US5650489A (en) * | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
GB9022190D0 (en) | 1990-10-12 | 1990-11-28 | Perham Richard N | Immunogenic material |
US5639603A (en) * | 1991-09-18 | 1997-06-17 | Affymax Technologies N.V. | Synthesizing and screening molecular diversity |
US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
US6088993A (en) | 1999-02-05 | 2000-07-18 | Irace; Francisco D. | Closure system |
JP2002537354A (ja) * | 1999-02-25 | 2002-11-05 | スミスクライン ビーチャム バイオロジカルズ ソシエテ アノニム | ペプチド、及びH.influenzaeのプロテインD由来の担体を含む免疫原 |
US6703491B1 (en) * | 1999-03-17 | 2004-03-09 | Exelixis, Inc. | Drosophila sequences |
DE60044057D1 (de) * | 1999-09-03 | 2010-05-06 | Univ Ramot | Verbindungen, zusammensetzungen und verfahren zur behandlung oder vorsorge von alzheimer erkrankung |
IL151355A0 (en) | 2000-03-03 | 2003-04-10 | Smithkline Beecham Biolog | Vaccine for the treatment of artherosclerosis |
GB0024200D0 (en) * | 2000-10-03 | 2000-11-15 | Smithkline Beecham Sa | Component vaccine |
DE50111493D1 (de) | 2001-09-03 | 2007-01-04 | Bio Life Science Forschungs & Entwicklungsgesellschaft Mbh | Antigen-Mimotope und Vakzine gegen Krebserkrankungen |
DE60216048T2 (de) * | 2002-05-07 | 2007-05-31 | Institut Pasteur | Screeningverfahren für Peptide, die die Bindung von PP1c an Bcl-2, BCL-Xl und BCL-W Proteine inhibieren |
-
2003
- 2003-09-17 AT AT0146403A patent/AT413945B/de not_active IP Right Cessation
-
2004
- 2004-01-13 DK DK05107898T patent/DK1679319T3/da active
- 2004-01-13 DE DE602004025668T patent/DE602004025668D1/de not_active Expired - Lifetime
- 2004-01-13 ES ES05107898T patent/ES2296084T3/es not_active Expired - Lifetime
- 2004-01-13 CN CN200480002213.2A patent/CN1826354B/zh not_active Expired - Fee Related
- 2004-01-13 EP EP04701585A patent/EP1583774B1/en not_active Expired - Lifetime
- 2004-01-13 ES ES04701585T patent/ES2339447T3/es not_active Expired - Lifetime
- 2004-01-13 DE DE602004009705T patent/DE602004009705T2/de not_active Expired - Lifetime
- 2004-01-13 SI SI200431399T patent/SI1583774T1/sl unknown
- 2004-01-13 JP JP2006500553A patent/JP4547373B2/ja not_active Expired - Fee Related
- 2004-01-13 DK DK04701585.4T patent/DK1583774T3/da active
- 2004-01-13 EP EP05107898A patent/EP1679319B1/en not_active Expired - Lifetime
- 2004-01-13 AT AT05107898T patent/ATE376559T1/de active
- 2004-01-13 WO PCT/EP2004/000162 patent/WO2004062556A2/en active Application Filing
- 2004-01-13 CA CA2513218A patent/CA2513218C/en not_active Expired - Fee Related
- 2004-01-13 AT AT04701585T patent/ATE458753T1/de active
- 2004-01-13 PL PL378333A patent/PL209989B1/pl unknown
- 2004-01-13 US US10/540,551 patent/US7732568B2/en not_active Expired - Fee Related
- 2004-01-13 PT PT04701585T patent/PT1583774E/pt unknown
- 2004-01-13 CN CN2011103110387A patent/CN102526699A/zh active Pending
- 2004-01-13 PT PT05107898T patent/PT1679319E/pt unknown
-
2006
- 2006-10-27 HK HK06111905.5A patent/HK1091499A1/xx not_active IP Right Cessation
-
2008
- 2008-01-17 CY CY20081100069T patent/CY1107146T1/el unknown
-
2010
- 2010-03-08 JP JP2010051012A patent/JP5282058B2/ja not_active Expired - Fee Related
- 2010-04-01 US US12/752,451 patent/US20110015131A1/en not_active Abandoned
- 2010-05-07 CY CY20101100399T patent/CY1110634T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1110634T1 (el) | Μεθοδοι προληψης και θεραπειας της νοσου του αλτσχαϊμερ (ad) | |
CY1108578T1 (el) | Φαρμακευτικες συνθεσεις (κιτ) περιλαμβανοντας ενωσεις διϋδροπυριδινονης και εναν ανοσορυθμιστικο (ή εναν αντιφλεγμονωδη) παραγοντα και οι χρησεις αυτων | |
NO20022531L (no) | Vaksine for forebyggelse og behandling av Alzheimer- og amyloidrelaterte sykdommer | |
CY1118037T1 (el) | Αντισωματα εναντι του αβητα και h χρηση τους | |
CY1118443T1 (el) | Anti-tnf αντισωματα, συνθεσεις, μεθοδοι και χρησεις | |
BRPI0418317A (pt) | vacina de aumento de crescimento à base de epitopo de neutralização | |
AU2002302255A1 (en) | Vaccine for the prevention and treatment of alzheimer's and amyloid related diseases | |
CY1110679T1 (el) | Νουκλεοτιδικες και πρωτεϊνικες ακολουθιες γονιδιων nogo και μεθοδοι βασιζομενες σε αυτες | |
CY1108638T1 (el) | Πρωτεϊνη συντηξης των hiv ρυθμιστικων/επικουρικων πρωτεϊνων | |
CY1108507T1 (el) | Σχετιζομενα με ογκους πεπτιδια δεσμευμενα σε μορια mhc | |
DE69435075D1 (de) | , die signalsequenzpeptide des endoplasmatischen reticulums und mindestens ein anderes peptid codieren, deren verwendung in impfstoffen und zur behandlung von krankheiten | |
CY1113218T1 (el) | Υβριδιο και διμερης εκφραση πρωτεϊνων ναϊσσεριας | |
DE60228758D1 (de) | Immunisierung gegen chlamydia tracheomatis | |
ATE510851T1 (de) | Auf peptiden basierende immunisierungstherapie zur behandlung von atherosklerose | |
ECSP093601A (es) | Proteínas derivadas del virus del síndrome de mancha blanca y sus usos | |
CY1114614T1 (el) | Αντιγονα αιμοφιλου ινφλουεντσας και αντιστοιχα dna θραυσματα | |
CY1105380T1 (el) | Προτιμωμενα τμηματα της νευρικης νηματικης πρωτεϊνης και μεθοδοι χρησης αυτων | |
EA200401114A2 (ru) | Замещённые гидроксиэтиламины | |
DK1417222T3 (da) | Isolerede polypeptider baseret på den neutraliserende epitop af p17-proteinet fra HIV egnet til vacciner samt neutraliserende anti-p17-antistoffer, der specifikt genkender nævnte neutraliserende epitop | |
NO20004168L (no) | Diagnostisk peptidreagens samt sett for pavisning av rickettsiosis | |
ATE396203T1 (de) | Auf peptiden basierende immunisierungstherapie zur behandlung von atheriosclerose | |
DE60035485D1 (de) | IDENTIFIZIERUNG VON SPEZIFISCHEN DIFFERENZIELL EXPRIMIERTEN ANTIGENEN AUS MYCOBACTERIUM UND MEDIZINISCHE VERWENDUNG DER MYCOBAKTERIUMPROTEINE Rv0068 UND Rv3407 | |
CY1108412T1 (el) | Συνθεσεις εμβολιου που περιλαμβανουν omp85 πρωτεϊνες απο neisseria gonorrhoea και neisseria miningitidis | |
ATE366261T1 (de) | Humane 7-transmembranproteine und dafür codierende polynukleotide | |
BRPI9917863B8 (pt) | composição farmacêutica que é uma vacina |