ATE376559T1 - Methoden der verhinderung und behandlung der alzheimer'schen krankheit - Google Patents
Methoden der verhinderung und behandlung der alzheimer'schen krankheitInfo
- Publication number
- ATE376559T1 ATE376559T1 AT05107898T AT05107898T ATE376559T1 AT E376559 T1 ATE376559 T1 AT E376559T1 AT 05107898 T AT05107898 T AT 05107898T AT 05107898 T AT05107898 T AT 05107898T AT E376559 T1 ATE376559 T1 AT E376559T1
- Authority
- AT
- Austria
- Prior art keywords
- arg
- glu
- asp
- tyr
- phe
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title abstract 5
- 230000002265 prevention Effects 0.000 title 1
- 229960005486 vaccine Drugs 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- RBXSZQRSEGYDFG-GUBZILKMSA-N Glu-Lys-Ser Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(O)=O RBXSZQRSEGYDFG-GUBZILKMSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 108010064539 amyloid beta-protein (1-42) Proteins 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 230000000324 neuroprotective effect Effects 0.000 abstract 1
- 230000001777 nootropic effect Effects 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Marine Sciences & Fisheries (AREA)
- Toxicology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT362003 | 2003-01-14 | ||
| AT0146403A AT413945B (de) | 2003-01-14 | 2003-09-17 | Impfstoff für die alzheimer-krankheit |
| PCT/EP2004/000162 WO2004062556A2 (en) | 2003-01-14 | 2004-01-13 | Methods for preventing and treating alzheimer’s disease (ad) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE376559T1 true ATE376559T1 (de) | 2007-11-15 |
Family
ID=32714004
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0146403A AT413945B (de) | 2003-01-14 | 2003-09-17 | Impfstoff für die alzheimer-krankheit |
| AT05107898T ATE376559T1 (de) | 2003-01-14 | 2004-01-13 | Methoden der verhinderung und behandlung der alzheimer'schen krankheit |
| AT04701585T ATE458753T1 (de) | 2003-01-14 | 2004-01-13 | Methoden der verhinderung und behandlung der alzheimer'schen krankheit |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0146403A AT413945B (de) | 2003-01-14 | 2003-09-17 | Impfstoff für die alzheimer-krankheit |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04701585T ATE458753T1 (de) | 2003-01-14 | 2004-01-13 | Methoden der verhinderung und behandlung der alzheimer'schen krankheit |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7732568B2 (de) |
| EP (2) | EP1679319B1 (de) |
| JP (2) | JP4547373B2 (de) |
| CN (2) | CN1826354B (de) |
| AT (3) | AT413945B (de) |
| CA (1) | CA2513218C (de) |
| CY (2) | CY1107146T1 (de) |
| DE (2) | DE602004025668D1 (de) |
| DK (2) | DK1679319T3 (de) |
| ES (2) | ES2296084T3 (de) |
| PL (1) | PL209989B1 (de) |
| PT (2) | PT1679319E (de) |
| SI (1) | SI1583774T1 (de) |
| WO (1) | WO2004062556A2 (de) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003303198A1 (en) | 2002-12-19 | 2004-07-14 | New York University | Method for treating amyloid disease |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| AT413336B (de) * | 2003-09-12 | 2006-02-15 | Mattner Frank Dr | Apherese-vorrichtung |
| WO2005072777A2 (en) * | 2004-01-28 | 2005-08-11 | Curix Aps | Conjugates of amyloid proteins as vaccines for amyloid-related diseases |
| AT413946B (de) * | 2004-07-13 | 2006-07-15 | Mattner Frank Dr | Impfstoff gegen die alzheimer-krankheit |
| AT500483B1 (de) * | 2004-07-13 | 2006-01-15 | Mattner Frank Dr | Set zur vorbeugung oder behandlung der alzheimer'schen erkrankung |
| KR101667623B1 (ko) | 2005-11-30 | 2016-10-19 | 애브비 인코포레이티드 | 아밀로이드 베타 단백질에 대한 모노클로날 항체 및 이의 용도 |
| KR20080090408A (ko) | 2005-11-30 | 2008-10-08 | 아보트 러보러터리즈 | 항-Ａβ 글로불로머 항체, 이의 항원-결합 잔기, 상응하는하이브리도마, 핵산, 벡터, 숙주 세포, 당해 항체의 제조방법, 당해 항체를 포함하는 조성물, 당해 항체의 용도 및당해 항체의 사용 방법 |
| MY167887A (en) * | 2005-12-12 | 2018-09-26 | Ac Immune Sa | A beta 1-42 specific monoclonal antibodies with therapeutic properties |
| EP1878747A1 (de) | 2006-07-11 | 2008-01-16 | greenovation Biotech GmbH | Glyco-hergestellte Antikörper |
| WO2008011348A2 (en) | 2006-07-14 | 2008-01-24 | Ac Immune S.A. | Humanized antibody against amyloid beta |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| EP2124952A2 (de) | 2007-02-27 | 2009-12-02 | Abbott GmbH & Co. KG | Verfahren zur behandlung von amyloidosen |
| US8613923B2 (en) * | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
| US8048420B2 (en) * | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
| ES2529174T3 (es) * | 2007-06-12 | 2015-02-17 | Ac Immune S.A. | Anticuerpos humanizados para amiloide beta |
| US9403902B2 (en) * | 2007-10-05 | 2016-08-02 | Ac Immune S.A. | Methods of treating ocular disease associated with amyloid-beta-related pathology using an anti-amyloid-beta antibody |
| RU2542967C2 (ru) * | 2007-10-05 | 2015-02-27 | Дженентек, Инк. | Применение антитела против амилоида бета при глазных заболеваниях |
| BRPI0818621A8 (pt) * | 2007-10-05 | 2018-01-30 | Ac Immune Sa | composição farmacêutica, e, métodos para reduzir a carga da placa e a quantidade de placas na camada de célula de gânglio retinal de um indivíduo, para prevenir, tratar e/ou aliviar os efeitos de uma doença ocular, para diagnosticar uma doença ocular e uma predisposição a uma doença ocular, para monitorar doença ocular, para predizer responsividade de um paciente, e para reter ou diminuir pressão ocular nos olhos de um indivíduo |
| US8586706B2 (en) | 2007-10-25 | 2013-11-19 | Kagoshima University | Peptide vaccine using mimic molecules of amyloid β peptide |
| JP5185946B2 (ja) * | 2007-10-29 | 2013-04-17 | Ｔａｏヘルスライフファーマ株式会社 | 抗体及びその利用 |
| NZ589302A (en) | 2008-04-17 | 2012-11-30 | Declion Pharmaceuticals Inc | Design and synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders |
| AT506819B1 (de) * | 2008-06-12 | 2011-06-15 | Affiris Forschungs Und Entwicklungs Gmbh | Vakzin zur behandlung von alzheimer-krankheit |
| AT506820B1 (de) * | 2008-06-12 | 2011-07-15 | Affiris Forschungs Und Entwicklungs Gmbh | Vakzine gegen alzheimer-krankheit |
| EP2310032A2 (de) * | 2008-06-12 | 2011-04-20 | Affiris AG | Verbindungen zur behandlung der symptome von parkinson-krankheit |
| CN102933601B (zh) | 2010-04-15 | 2016-06-08 | Abbvie公司 | β淀粉样蛋白结合蛋白 |
| CN103179981B (zh) | 2010-07-30 | 2017-02-08 | Ac免疫有限公司 | 安全和功能性的人源化抗β‑淀粉样蛋白抗体 |
| CN103298833B (zh) | 2010-08-14 | 2015-12-16 | Abbvie公司 | β淀粉样蛋白结合蛋白 |
| US20120321694A1 (en) * | 2010-10-27 | 2012-12-20 | Daniel Larocque | Compositions and uses |
| GB201113570D0 (en) | 2011-08-05 | 2011-09-21 | Glaxosmithkline Biolog Sa | Vaccine |
| PL2579042T3 (pl) | 2011-10-04 | 2014-12-31 | Affiris Ag | Sposób wykrywania przeciwciał swoistych wobec Aß w próbce biologicznej |
| EP2787347A1 (de) | 2013-04-03 | 2014-10-08 | Affiris AG | Verfahren zur Erkennung von Aß-spezifischen Antikörpern in einer biologischen Probe |
| US10381614B2 (en) * | 2013-04-17 | 2019-08-13 | Samsung Sdi Co., Ltd. | Battery module |
| WO2015165961A1 (en) | 2014-04-29 | 2015-11-05 | Affiris Ag | Treatment and prevention of alzheimer's disease (ad) |
| AU2016348610B2 (en) | 2015-11-03 | 2023-08-31 | Ac Immune Sa | Method for vaccination against a self-antigen in a human patient |
| CN105237628B (zh) * | 2015-11-17 | 2018-08-07 | 南开大学 | 一种用于治疗阿尔兹海默症的多肽 |
| CN107022019B (zh) * | 2016-11-24 | 2020-10-30 | 桂林医学院 | 一种用于脑内降铁除自由基的多肽、制备方法与应用 |
| CA3070446A1 (en) | 2017-07-25 | 2019-01-31 | Immutics, Inc. | Treating cancer by blocking the interaction of tim-3 and its ligand |
| EP3918323A4 (de) | 2019-01-30 | 2022-12-28 | TrueBinding, Inc. | Anti-gal3-antikörper und verwendungen davon |
| CA3185040A1 (en) | 2020-05-26 | 2021-12-02 | Truebinding, Inc. | Methods of treating inflammatory diseases by blocking galectin-3 |
| US20250186595A1 (en) | 2022-02-28 | 2025-06-12 | Tridem Bioscience Gmbh & Co Kg | A CONJUGATE CONSISTING OF OR COMPRISING AT LEAST A ß-GLUCAN OR A MANNAN |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK590288D0 (da) * | 1988-10-24 | 1988-10-24 | Symbicom Ab | Kemiske forbindelser |
| US5650489A (en) * | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
| GB9022190D0 (en) | 1990-10-12 | 1990-11-28 | Perham Richard N | Immunogenic material |
| US5639603A (en) * | 1991-09-18 | 1997-06-17 | Affymax Technologies N.V. | Synthesizing and screening molecular diversity |
| US7964192B1 (en) * | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| US6088993A (en) | 1999-02-05 | 2000-07-18 | Irace; Francisco D. | Closure system |
| CA2363118A1 (en) | 1999-02-25 | 2000-08-31 | Smithkline Beecham Biologicals S.A. | Immunogens comprising a peptide and a carrier derived from h.influenzae protein d |
| US6703491B1 (en) * | 1999-03-17 | 2004-03-09 | Exelixis, Inc. | Drosophila sequences |
| WO2001018169A2 (en) * | 1999-09-03 | 2001-03-15 | Ramot University Authority For Applied Research & Industrial Development Ltd. | Agents and compositions and methods for diagnostic and/or treating or preventing plaque forming diseases |
| JP2003525883A (ja) | 2000-03-03 | 2003-09-02 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | ワクチン |
| GB0024200D0 (en) * | 2000-10-03 | 2000-11-15 | Smithkline Beecham Sa | Component vaccine |
| ES2276732T3 (es) | 2001-09-03 | 2007-07-01 | Bio Life Science Forschungs- Und Entwicklungsges.M.B.H. | Mimotopos de antigenos y vacuna contra enfermedades cancerosas. |
| DE60216048T2 (de) | 2002-05-07 | 2007-05-31 | Institut Pasteur | Screeningverfahren für Peptide, die die Bindung von PP1c an Bcl-2, BCL-Xl und BCL-W Proteine inhibieren |
-
2003
- 2003-09-17 AT AT0146403A patent/AT413945B/de not_active IP Right Cessation
-
2004
- 2004-01-13 ES ES05107898T patent/ES2296084T3/es not_active Expired - Lifetime
- 2004-01-13 AT AT05107898T patent/ATE376559T1/de active
- 2004-01-13 CA CA2513218A patent/CA2513218C/en not_active Expired - Fee Related
- 2004-01-13 DK DK05107898T patent/DK1679319T3/da active
- 2004-01-13 EP EP05107898A patent/EP1679319B1/de not_active Expired - Lifetime
- 2004-01-13 WO PCT/EP2004/000162 patent/WO2004062556A2/en not_active Ceased
- 2004-01-13 CN CN200480002213.2A patent/CN1826354B/zh not_active Expired - Fee Related
- 2004-01-13 JP JP2006500553A patent/JP4547373B2/ja not_active Expired - Fee Related
- 2004-01-13 US US10/540,551 patent/US7732568B2/en not_active Expired - Fee Related
- 2004-01-13 PT PT05107898T patent/PT1679319E/pt unknown
- 2004-01-13 EP EP04701585A patent/EP1583774B1/de not_active Expired - Lifetime
- 2004-01-13 ES ES04701585T patent/ES2339447T3/es not_active Expired - Lifetime
- 2004-01-13 DE DE602004025668T patent/DE602004025668D1/de not_active Expired - Lifetime
- 2004-01-13 PL PL378333A patent/PL209989B1/pl unknown
- 2004-01-13 CN CN2011103110387A patent/CN102526699A/zh active Pending
- 2004-01-13 DK DK04701585.4T patent/DK1583774T3/da active
- 2004-01-13 DE DE602004009705T patent/DE602004009705T2/de not_active Expired - Lifetime
- 2004-01-13 SI SI200431399T patent/SI1583774T1/sl unknown
- 2004-01-13 AT AT04701585T patent/ATE458753T1/de active
- 2004-01-13 PT PT04701585T patent/PT1583774E/pt unknown
-
2008
- 2008-01-17 CY CY20081100069T patent/CY1107146T1/el unknown
-
2010
- 2010-03-08 JP JP2010051012A patent/JP5282058B2/ja not_active Expired - Fee Related
- 2010-04-01 US US12/752,451 patent/US20110015131A1/en not_active Abandoned
- 2010-05-07 CY CY20101100399T patent/CY1110634T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEIH | Change in the person of patent owner |