EA200700083A1 - Антитела, направленные против бета-амилоидного пептида, и способы их применения - Google Patents

Антитела, направленные против бета-амилоидного пептида, и способы их применения

Info

Publication number
EA200700083A1
EA200700083A1 EA200700083A EA200700083A EA200700083A1 EA 200700083 A1 EA200700083 A1 EA 200700083A1 EA 200700083 A EA200700083 A EA 200700083A EA 200700083 A EA200700083 A EA 200700083A EA 200700083 A1 EA200700083 A1 EA 200700083A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
directed against
amyloid peptide
against beta
antibodies directed
Prior art date
Application number
EA200700083A
Other languages
English (en)
Other versions
EA016357B1 (ru
Inventor
Арнон Розенталь
Хауме Понс
Вей-Хсиен Хо
Ян Маркус Гримм
Original Assignee
Ринат Ньюросайенс Корп.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ринат Ньюросайенс Корп. filed Critical Ринат Ньюросайенс Корп.
Publication of EA200700083A1 publication Critical patent/EA200700083A1/ru
Publication of EA016357B1 publication Critical patent/EA016357B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

Описано моноклональное антитело 9TL и антитела, имеющие происхождение из 9TL, направленные против бета-амилоидного пептида, и способы их применения для диагностики и лечения болезни Альцгеймера и заболеваний, ассоциированных с Аβ-пептидом. Также описаны способы применения антител, направленных против бета-амилоидного пептида с нарушенной эффекторной функцией, для лечения болезни Альцгеймера и заболеваний, ассоциированных с Аβ-пептидом.
EA200700083A 2004-07-30 2005-08-01 Антитела, направленные против бета-амилоидного пептида, и способы их применения EA016357B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US59249404P 2004-07-30 2004-07-30
US65319705P 2005-02-14 2005-02-14
US67609305P 2005-04-29 2005-04-29
PCT/US2005/027295 WO2006036291A2 (en) 2004-07-30 2005-08-01 Antibodies directed against amyloid-beta peptide and methods using same

Publications (2)

Publication Number Publication Date
EA200700083A1 true EA200700083A1 (ru) 2008-02-28
EA016357B1 EA016357B1 (ru) 2012-04-30

Family

ID=36010949

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200700083A EA016357B1 (ru) 2004-07-30 2005-08-01 Антитела, направленные против бета-амилоидного пептида, и способы их применения

Country Status (21)

Country Link
US (4) US7807165B2 (ru)
EP (2) EP2298807A3 (ru)
JP (2) JP5042828B2 (ru)
KR (2) KR20070040824A (ru)
AP (1) AP2007003890A0 (ru)
AU (2) AU2005290250A1 (ru)
BR (1) BRPI0513959A (ru)
CA (1) CA2575663C (ru)
EA (1) EA016357B1 (ru)
GE (1) GEP20115195B (ru)
HK (1) HK1116500A1 (ru)
IL (1) IL180364A (ru)
MA (1) MA28757B1 (ru)
MX (1) MX2007000998A (ru)
NI (1) NI200700021A (ru)
NO (1) NO20066058L (ru)
NZ (1) NZ552480A (ru)
SG (1) SG190665A1 (ru)
TN (1) TNSN07031A1 (ru)
TW (1) TWI355389B (ru)
WO (1) WO2006036291A2 (ru)

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