MX368391B - Ciclopropabenzofuranil-piridopirazindionas novedosas. - Google Patents

Ciclopropabenzofuranil-piridopirazindionas novedosas.

Info

Publication number
MX368391B
MX368391B MX2017010019A MX2017010019A MX368391B MX 368391 B MX368391 B MX 368391B MX 2017010019 A MX2017010019 A MX 2017010019A MX 2017010019 A MX2017010019 A MX 2017010019A MX 368391 B MX368391 B MX 368391B
Authority
MX
Mexico
Prior art keywords
pyridopyrazinediones
cyclopropabenzofuranyl
novel
compounds
disclosed
Prior art date
Application number
MX2017010019A
Other languages
English (en)
Other versions
MX2017010019A (es
Inventor
Robert Verhoest Patrick
William Am Ende Christopher
Scott Johnson Douglas
Wayne Kauffman Gregory
Friederike Stepan Antonia
Youngjin Pettersson Martin
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MX2017010019A publication Critical patent/MX2017010019A/es
Publication of MX368391B publication Critical patent/MX368391B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Se describen compuestos y sales farmacéuticamente aceptables de los compuestos en donde los compuestos tienen la estructura de la Fórmula I (ver Fórmula) en donde X, R1, R2a, R2b, R4a, R4b, R5a, R5b, R6, R7, R10, R11, e y son como se definen en la especificación. También se describen las composiciones farmacéuticas correspondientes, métodos de tratamiento, métodos de síntesis, e intermediarios.
MX2017010019A 2015-02-03 2016-01-26 Ciclopropabenzofuranil-piridopirazindionas novedosas. MX368391B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562111222P 2015-02-03 2015-02-03
PCT/IB2016/050384 WO2016125048A1 (en) 2015-02-03 2016-01-26 Novel cyclopropabenzofuranyl pyridopyrazinediones

Publications (2)

Publication Number Publication Date
MX2017010019A MX2017010019A (es) 2017-10-24
MX368391B true MX368391B (es) 2019-09-30

Family

ID=55299692

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017010019A MX368391B (es) 2015-02-03 2016-01-26 Ciclopropabenzofuranil-piridopirazindionas novedosas.

Country Status (22)

Country Link
US (2) US20160222007A1 (es)
EP (1) EP3253755B1 (es)
JP (1) JP6628805B2 (es)
KR (1) KR102000382B1 (es)
CN (1) CN107406445B (es)
AR (1) AR103582A1 (es)
AU (1) AU2016214102B2 (es)
BR (1) BR112017015693A2 (es)
CA (1) CA2919338A1 (es)
DK (1) DK3253755T3 (es)
EA (1) EA033423B1 (es)
EC (1) ECSP17050310A (es)
ES (1) ES2818806T3 (es)
IL (1) IL253635A0 (es)
MX (1) MX368391B (es)
PE (1) PE20171318A1 (es)
PH (1) PH12017501369A1 (es)
SG (1) SG11201705780PA (es)
TN (1) TN2017000342A1 (es)
TW (1) TWI616445B (es)
UY (1) UY36546A (es)
WO (1) WO2016125048A1 (es)

Families Citing this family (5)

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KR102271305B1 (ko) 2020-05-21 2021-06-30 주식회사 아리바이오 치매 예방 및 치료용 조성물
CN111978324A (zh) * 2020-08-28 2020-11-24 开封康诺药业有限公司 一种多索茶碱的晶型及其制备方法
KR102272907B1 (ko) 2020-11-05 2021-07-05 주식회사 아리바이오 치매 예방 및 치료용 조성물
KR102272910B1 (ko) 2021-01-28 2021-07-06 주식회사 아리바이오 당뇨병을 동반한 치매 예방 및 치료용 조성물
KR102311224B1 (ko) * 2021-04-23 2021-10-13 주식회사 아리바이오 Pde5 억제제와 글루코코르티코이드 수용체 길항제 병용투여를 통한 치매 예방 및 치료용 조성물

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