US2007107A
(en)
|
1934-03-07 |
1935-07-02 |
Bottrill David Hugh |
Combined soap and massage articles
|
GB1419788A
(en)
|
1972-08-02 |
1975-12-31 |
Pfizer |
Herbicidal method using 2-trifuluromethyl-4-quinolinols
|
WO1992000075A1
(en)
|
1990-06-29 |
1992-01-09 |
Pfizer Inc. |
Pyridopyrazine derivatives for treating substance abuse and addiction
|
ATE161530T1
(de)
|
1992-09-04 |
1998-01-15 |
Takeda Chemical Industries Ltd |
Kondensierte heterozyklische verbindungen, deren herstellung und verwendung
|
ATE239797T1
(de)
|
1993-01-25 |
2003-05-15 |
Takeda Chemical Industries Ltd |
Antikörper gegen beta-amyloid oder derivative davon und seine verwendung
|
ES2194937T3
(es)
|
1995-03-24 |
2003-12-01 |
Takeda Chemical Industries Ltd |
Compuestos ciclicos, su produccion y uso como antagonistas de los receptores de taquiquinina.
|
DE19709877A1
(de)
|
1997-03-11 |
1998-09-17 |
Bayer Ag |
1,5-Dihydro-pyrazolo[3,4-d]-pyrimidinon-derivate
|
JP3816111B2
(ja)
|
1997-04-09 |
2006-08-30 |
インテレクト・ニューロサイエンシズ・インコーポレーテッド |
β−アミロイド末端に特異的な組換え抗体、それをコードするDNA及びその使用法
|
US8173127B2
(en)
|
1997-04-09 |
2012-05-08 |
Intellect Neurosciences, Inc. |
Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof
|
GB9722520D0
(en)
|
1997-10-24 |
1997-12-24 |
Pfizer Ltd |
Compounds
|
TWI239847B
(en)
|
1997-12-02 |
2005-09-21 |
Elan Pharm Inc |
N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
|
US6905686B1
(en)
|
1997-12-02 |
2005-06-14 |
Neuralab Limited |
Active immunization for treatment of alzheimer's disease
|
CA2322156A1
(en)
|
1998-03-03 |
1999-09-10 |
Ppg Industries Ohio, Inc. |
Impregnated glass fiber strands and products including the same
|
US20020132817A1
(en)
|
1998-03-19 |
2002-09-19 |
Hideaki Natsugari |
Heterocyclic compounds, their production and use
|
CA2352612A1
(en)
|
1998-11-27 |
2000-06-08 |
Hideo Fukui |
Pharmaceuticals
|
BRPI0108676B8
(pt)
|
2000-02-24 |
2021-05-25 |
Lilly Co Eli |
anticorpos humanizados que sequestram peptídeo amilóide beta e seus usos no tratamento de condições caracterizadas por formação de placas amiloides, bem como composição farmacêutica que compreende os referidos anticorpos
|
DE10045112A1
(de)
|
2000-09-11 |
2002-03-21 |
Merck Patent Gmbh |
Verwendung von Indolderivaten zur Behandlung von Erkrankungen des zentralen Nervensystems
|
EP1335738A4
(en)
|
2000-11-03 |
2004-09-08 |
Proteotech Inc |
METHODS OF ISOLATING AMYLOID INHIBITOR COMPOUNDS AND USE OF COMPOUNDS USED FROM UNCARIA TOMENTOSA AND PARENT PLANTS
|
EP1432444A4
(en)
|
2001-08-17 |
2005-11-02 |
Lilly Co Eli |
ANTI-BETA ANTIBODIES
|
US20030195205A1
(en)
|
2001-11-02 |
2003-10-16 |
Pfizer Inc. |
PDE9 inhibitors for treating cardiovascular disorders
|
DE10238724A1
(de)
|
2002-08-23 |
2004-03-04 |
Bayer Ag |
Alkyl-substituierte Pyrazolpyrimidine
|
DE10238723A1
(de)
|
2002-08-23 |
2004-03-11 |
Bayer Ag |
Phenyl-substituierte Pyrazolyprimidine
|
AU2003267098B2
(en)
|
2002-09-11 |
2008-11-20 |
Merck & Co., Inc. |
Dihydroxypyridopyrazine-1,6-dione compounds useful as HIV integrase inhibitors
|
EP1633786A4
(en)
|
2002-10-09 |
2007-07-25 |
Rinat Neuroscience Corp |
METHOD FOR TREATING ALZHEIMER DISEASE WITH ANTIBODIES TO AMYLOID BETA PEPTIDE AND COMPOSITIONS THEREOF
|
WO2004033434A1
(en)
|
2002-10-09 |
2004-04-22 |
Pfizer Products Inc. |
Pyrazole compounds for treatment of neurodegenerative disorders
|
US20040157804A1
(en)
|
2002-10-16 |
2004-08-12 |
Gilead Sciences, Inc. |
Pre-organized tricyclic integrase inhibitor compounds
|
US20040220186A1
(en)
|
2003-04-30 |
2004-11-04 |
Pfizer Inc. |
PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
|
BRPI0410630A
(pt)
|
2003-06-19 |
2006-06-13 |
Pfizer Prod Inc |
antagonista de nk1
|
EP1658072A4
(en)
|
2003-08-21 |
2009-03-25 |
Pfizer Prod Inc |
Compounds for the Treatment of Neurodegenerative Diseases
|
WO2005025616A1
(ja)
|
2003-09-09 |
2005-03-24 |
Takeda Pharmaceutical Company Limited |
抗体の用途
|
US7572799B2
(en)
|
2003-11-24 |
2009-08-11 |
Pfizer Inc |
Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
|
GB0327319D0
(en)
|
2003-11-24 |
2003-12-24 |
Pfizer Ltd |
Novel pharmaceuticals
|
EP1718152A4
(en)
|
2004-01-28 |
2009-09-16 |
Merck & Co Inc |
AMINOCYCLOPENTYL MODULATORS PYRIDOPYRAZINONE OF CHEMOKINE RECEPTOR ACTIVITY
|
BRPI0507374A
(pt)
|
2004-02-02 |
2007-07-10 |
Pfizer Prod Inc |
moduladores do receptor de histamina-3
|
AU2005227258A1
(en)
|
2004-03-09 |
2005-10-06 |
Merck & Co., Inc. |
HIV integrase inhibitors
|
CN1934091B
(zh)
|
2004-03-23 |
2012-02-08 |
辉瑞产品公司 |
治疗神经变性障碍的咪唑化合物
|
ES2315922T3
(es)
|
2004-04-14 |
2009-04-01 |
Gilead Sciences, Inc. |
Analogos de fosfonato de compuestos inhibidores de la integrasa del vih.
|
US7456164B2
(en)
|
2004-05-07 |
2008-11-25 |
Pfizer, Inc |
3- or 4-monosubtituted phenol and thiophenol derivatives useful as H3 ligands
|
EP1595881A1
(en)
|
2004-05-12 |
2005-11-16 |
Pfizer Limited |
Tetrahydronaphthyridine derivates useful as histamine H3 receptor ligands
|
EP2298807A3
(en)
|
2004-07-30 |
2011-05-18 |
Rinat Neuroscience Corp. |
Antibodies directed against amyloid-beta peptide and methods using same
|
GB0423356D0
(en)
|
2004-10-21 |
2004-11-24 |
Merck Sharp & Dohme |
Therapeutic agents
|
WO2006069081A2
(en)
|
2004-12-22 |
2006-06-29 |
Washington University In St. Louis |
USE OF ANTI-Aβ ANTIBODY TO TREAT TRAUMATIC BRAIN INJURY
|
UY29504A1
(es)
|
2005-04-29 |
2006-10-31 |
Rinat Neuroscience Corp |
Anticuerpos dirigidos contra el péptido amiloide beta y métodos que utilizan los mismos.
|
EP1881825B1
(en)
|
2005-05-10 |
2013-07-24 |
Merck Sharp & Dohme Corp. |
Hiv integrase inhibitors
|
NZ564187A
(en)
|
2005-05-12 |
2010-03-26 |
Pfizer |
Anhydrous crystalline forms of N-[1-(2-ethoxyethyl)-5-(N-ethyl-N-methylamino)-7-(4-methylpyridin-2-yl-amino)-1H-pyrazolo[4,3-d]pyrimidine-3-carbonyl]methanesulfonamide
|
CA2608672A1
(en)
|
2005-05-24 |
2006-11-30 |
Pharmacia & Upjohn Company Llc |
Pyridine [3,4-b] pyrazinones as pde-5 inhibitors
|
WO2006126081A2
(en)
|
2005-05-24 |
2006-11-30 |
Pharmacia & Upjohn Company Llc |
Pyridino [2 , 3-b] pyrazinones as pde-5 inhibitors
|
WO2006126083A1
(en)
|
2005-05-24 |
2006-11-30 |
Pharmacia & Upjohn Company Llc |
Pyridine [3 , 4-b] pyrazinone compounds as pde-5 inhibitors
|
US7812040B2
(en)
|
2005-06-22 |
2010-10-12 |
Pfizer Inc. |
Histamine-3 receptor antagonists
|
US8158673B2
(en)
|
2005-10-27 |
2012-04-17 |
Pfizer Inc. |
Histamine-3 receptor antagonists
|
JP2009515997A
(ja)
|
2005-11-18 |
2009-04-16 |
タケダ サン ディエゴ インコーポレイテッド |
グルコキナーゼ活性剤
|
US20070117839A1
(en)
|
2005-11-24 |
2007-05-24 |
Eisai R&D Management Co., Ltd. |
Two cyclic cinnamide compound
|
MY144960A
(en)
|
2005-11-24 |
2011-11-30 |
Eisai R&D Man Co Ltd |
Morpholine type cinnamide compound
|
WO2007063385A2
(en)
|
2005-12-01 |
2007-06-07 |
Pfizer Products Inc. |
Spirocyclic amine histamine-3 receptor antagonists
|
WO2007069053A1
(en)
|
2005-12-14 |
2007-06-21 |
Pfizer Products Inc. |
Benzimidazole antagonists of the h-3 receptor
|
RU2448964C2
(ru)
|
2006-01-20 |
2012-04-27 |
Шеринг Корпорейшн |
КАРБОЦИКЛИЧЕСКИЕ И ГЕТЕРОЦИКЛИЧЕСКИЕ АРИЛСУЛЬФОНЫ, ИХ ПРИМЕНЕНИЕ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ИХ ОСНОВЕ, ОБЛАДАЮЩАЯ СВОЙСТВАМИ ИНГИБИТОРА γ-СЕКРЕТАЗЫ
|
WO2007088462A1
(en)
|
2006-02-01 |
2007-08-09 |
Pfizer Products Inc. |
Spirochromane antagonists of the h-3 receptor
|
WO2007088450A2
(en)
|
2006-02-01 |
2007-08-09 |
Pfizer Products Inc. |
Chromane antagonist of the h-3 receptor
|
WO2007099423A1
(en)
|
2006-03-02 |
2007-09-07 |
Pfizer Products Inc. |
1-pyrrolidine indane derivatives as histamine-3 receptor antagonists
|
TWI378091B
(en)
|
2006-03-09 |
2012-12-01 |
Eisai R&D Man Co Ltd |
Multi-cyclic cinnamide derivatives
|
US20090163482A1
(en)
|
2006-03-13 |
2009-06-25 |
Mchardy Stanton Furst |
Tetralines antagonists of the h-3 receptor
|
AU2007242555B2
(en)
|
2006-04-21 |
2010-12-16 |
Pfizer Products Inc. |
Pyridine[3,4-b]pyrazinones
|
WO2007136714A2
(en)
|
2006-05-16 |
2007-11-29 |
Gilead Sciences, Inc. |
Integrase inhibitors
|
CN101448793A
(zh)
|
2006-05-19 |
2009-06-03 |
卫材R&D管理有限公司 |
脲型肉桂酰胺衍生物
|
WO2007138431A2
(en)
|
2006-05-30 |
2007-12-06 |
Pfizer Products Inc. |
Azabicyclic ether histamine-3 antagonists
|
PT2124933E
(pt)
|
2007-01-22 |
2013-01-07 |
Pfizer Prod Inc |
Sal tosilato de um composto terapêutico e composições farmacêuticas do mesmo
|
JP2010518083A
(ja)
|
2007-02-12 |
2010-05-27 |
メルク・シャープ・エンド・ドーム・コーポレイション |
ピペリジン誘導体
|
AU2008215948A1
(en)
|
2007-02-12 |
2008-08-21 |
Merck & Co., Inc. |
Piperazine derivatives for treatment of AD and related conditions
|
US20080207900A1
(en)
|
2007-02-28 |
2008-08-28 |
Teiji Kimura |
Two cyclic oxomorphorin derivatives
|
WO2008137102A2
(en)
|
2007-05-04 |
2008-11-13 |
Torreypines Therapeutics, Inc. |
Methods of modulating amyloid beta and compounds useful therefor
|
RU2009144998A
(ru)
|
2007-05-07 |
2011-06-20 |
Шеринг Корпорейшн (US) |
Модуляторы гамма-секретазы
|
RU2009140182A
(ru)
|
2007-05-11 |
2011-06-20 |
Ф. Хоффманн-Ля Рош Аг (Ch) |
Гетариланилины в качестве модуляторов для бета-амилоида
|
WO2008153793A2
(en)
|
2007-06-01 |
2008-12-18 |
Schering Corporation |
Gamma secretase modulators
|
WO2008153792A2
(en)
|
2007-06-01 |
2008-12-18 |
Schering Corporation |
Gamma secretase modulators
|
WO2008156580A1
(en)
|
2007-06-13 |
2008-12-24 |
Merck & Co., Inc. |
Triazole derivatives for treating alzheimer's disease and related conditions
|
US20110053918A1
(en)
|
2007-06-29 |
2011-03-03 |
Zhaoning Zhu |
Gamma secretase modulators
|
WO2009020580A1
(en)
|
2007-08-06 |
2009-02-12 |
Schering Corporation |
Gamma secretase modulators
|
EP2559693B1
(en)
|
2007-08-31 |
2014-11-26 |
Eisai R&D Management Co., Ltd. |
Polycyclic compound
|
US7935815B2
(en)
|
2007-08-31 |
2011-05-03 |
Eisai R&D Management Co., Ltd. |
Imidazoyl pyridine compounds and salts thereof
|
WO2009032277A1
(en)
|
2007-09-06 |
2009-03-12 |
Schering Corporation |
Gamma secretase modulators
|
JP2010540524A
(ja)
|
2007-09-28 |
2010-12-24 |
シェーリング コーポレイション |
ガンマセクレターゼモジュレーター
|
GB0720444D0
(en)
|
2007-10-18 |
2007-11-28 |
Glaxo Group Ltd |
Novel compounds
|
WO2009061699A1
(en)
|
2007-11-05 |
2009-05-14 |
Schering Corporation |
Gamma secretase modulators
|
JP2011506336A
(ja)
|
2007-12-06 |
2011-03-03 |
シェーリング コーポレイション |
γ−セクレターゼ調節剤
|
EP2227471A1
(en)
|
2007-12-11 |
2010-09-15 |
Schering Corporation |
Gamma secretase modulators
|
MX2010006379A
(es)
|
2007-12-11 |
2010-09-07 |
Schering Corp |
Moduladores de la secretasa gamma.
|
WO2009075874A1
(en)
|
2007-12-13 |
2009-06-18 |
Amgen Inc. |
Gamma secretase modulators
|
BRPI0906799A2
(pt)
|
2008-01-11 |
2015-07-14 |
Hoffmann La Roche |
Moduladores para amiloide beta
|
JP5328816B2
(ja)
|
2008-02-22 |
2013-10-30 |
エフ.ホフマン−ラ ロシュ アーゲー |
アミロイドβの調節薬
|
US20100137320A1
(en)
|
2008-02-29 |
2010-06-03 |
Schering Corporation |
Gamma secretase modulators
|
JP2011513323A
(ja)
|
2008-02-29 |
2011-04-28 |
シェーリング コーポレイション |
アルツハイマー病の治療のためのγ−セクレターゼモジュレーター
|
BRPI0912539A2
(pt)
|
2008-05-05 |
2015-10-13 |
Amgen Inc |
composto, composição farmacêutica , método para tratar uma doença, e, uso do composto.
|
TW201006801A
(en)
|
2008-07-18 |
2010-02-16 |
Lilly Co Eli |
Imidazole carboxamides
|
EP2312945A4
(en)
|
2008-08-13 |
2012-05-09 |
Merck Sharp & Dohme |
PURE DERIVATIVES FOR THE TREATMENT OF MORBUS ALZHEIMER
|
WO2010019393A1
(en)
|
2008-08-13 |
2010-02-18 |
Merck Sharp & Dohme Corp. |
Pyrimidine derivatives for treatment of alzheimer's disease
|
RU2011111534A
(ru)
|
2008-08-27 |
2012-10-10 |
ЭЙСАЙ Ар энд Ди МЕНЕДЖМЕНТ КО., ЛТД. (JP) |
Способ получения определенных цинниамидных соединений
|
MX2011003246A
(es)
|
2008-10-09 |
2011-04-21 |
Hoffmann La Roche |
Moduladores de beta amiloide.
|
US20120129846A1
(en)
|
2008-11-06 |
2012-05-24 |
Zhaoning Zhu |
Gamma secretase modulators
|
KR20110082189A
(ko)
|
2008-11-06 |
2011-07-18 |
아스트라제네카 아베 |
아밀로이드 베타의 조절제
|
JP2012508180A
(ja)
|
2008-11-06 |
2012-04-05 |
シェーリング コーポレイション |
γ−セクレターゼ調節剤
|
WO2010052199A1
(en)
|
2008-11-10 |
2010-05-14 |
F. Hoffmann-La Roche Ag |
Heterocyclic gamma secretase modulators
|
EP2379075A4
(en)
|
2008-12-16 |
2012-05-30 |
Merck Sharp & Dohme |
TRIAZOL DERIVATIVES FOR THE TREATMENT OF ALZHEIMER DISEASE
|
WO2010071741A1
(en)
|
2008-12-16 |
2010-06-24 |
Merck Sharp & Dohme Corp. |
Triazole derivatives for treatment of alzheimer's disease
|
PA8854101A1
(es)
|
2008-12-18 |
2010-07-27 |
Ortho Mcneil Janssen Pharm |
Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa
|
TW201034666A
(en)
|
2008-12-22 |
2010-10-01 |
Schering Corp |
Gamma secretase modulators
|
AU2009330234A1
(en)
|
2008-12-22 |
2011-07-07 |
Merck Sharp & Dohme Corp. |
Gamma secretase modulators
|
TW201030002A
(en)
|
2009-01-16 |
2010-08-16 |
Bristol Myers Squibb Co |
Bicyclic compounds for the reduction of beta-amyloid production
|
NZ593951A
(en)
|
2009-02-06 |
2013-01-25 |
Ortho Mcneil Janssen Pharm |
Novel substituted bicyclic heterocyclic compounds as gamma secretase modulators
|
TWI461425B
(zh)
|
2009-02-19 |
2014-11-21 |
Janssen Pharmaceuticals Inc |
作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類
|
JP2012121809A
(ja)
|
2009-02-26 |
2012-06-28 |
Eisai R & D Management Co Ltd |
多環式化合物の製造法およびその中間体
|
JP2012051807A
(ja)
|
2009-02-26 |
2012-03-15 |
Eisai R & D Management Co Ltd |
アリールイミダゾール化合物
|
JP2012051806A
(ja)
|
2009-02-26 |
2012-03-15 |
Eisai R & D Management Co Ltd |
イミダゾリルピラジン誘導体
|
JP2012051805A
(ja)
|
2009-02-26 |
2012-03-15 |
Eisai R & D Management Co Ltd |
テトラヒドロトリアゾロピリジン誘導体の製造方法
|
AU2010218667A1
(en)
|
2009-02-26 |
2011-07-21 |
Eisai R&D Management Co., Ltd. |
Salt of tetrahydrotriazolopyridine derivative and crystal thereof
|
JP2012519682A
(ja)
|
2009-03-03 |
2012-08-30 |
ファイザー・インク |
ガンマ−セクレターゼモジュレーターとしての新規フェニルイミダゾールおよびフェニルトリアゾール
|
JP2013508350A
(ja)
|
2009-10-20 |
2013-03-07 |
ファイザー・インク |
ガンマ−セクレターゼモジュレーターとしての新規なヘテロアリールイミダゾールおよびヘテロアリールトリアゾール
|
WO2012131539A1
(en)
|
2011-03-31 |
2012-10-04 |
Pfizer Inc. |
Novel bicyclic pyridinones
|
AU2013261023B2
(en)
*
|
2012-05-16 |
2016-11-24 |
Cellzome Limited |
Substituted 3, 4 - dihydro - 2H - pyrido [1, 2 -a] pyrazine - 1, 6 - dione derivatives useful for the treatment of (inter alia) Alzheimer's disease
|
UA110688C2
(uk)
*
|
2012-09-21 |
2016-01-25 |
Пфайзер Інк. |
Біциклічні піридинони
|
TWI614238B
(zh)
|
2012-09-21 |
2018-02-11 |
必治妥美雅史谷比公司 |
雙(氟烷基)-1,4-苯并二氮呯酮化合物及其前藥
|
WO2014096212A1
(en)
|
2012-12-20 |
2014-06-26 |
Janssen Pharmaceutica Nv |
NOVEL TRICYCLIC 3,4-DIHYDRO-2H-PYRIDO[1,2-α]PYRAZINE-1,6-DIONE DERIVATIVES AS GAMMA SECRETASE MODULATORS
|
EP2945944B1
(en)
*
|
2013-01-17 |
2016-11-09 |
Janssen Pharmaceutica, N.V. |
Novel substituted pyrido-piperazinone derivatives as gamma secretase modulators
|
CA2925743C
(en)
|
2013-10-04 |
2018-03-06 |
Pfizer Inc. |
Novel bicyclic pyridinones as gamma-secretase modulators
|
CN106413623B
(zh)
|
2014-03-21 |
2020-07-03 |
阿莱恩技术有限公司 |
具有弹性体的分段的正畸矫正器
|
MD20160102A2
(ro)
*
|
2014-04-01 |
2017-04-30 |
Pfizer Inc. |
Cromen şi 1,1a,2,7b-tetrahidrociclopropa[c]cromen piridopirazindione ca modulatori ai gama-secretazei
|