EA033423B1 - Циклопропанбензофуранилпиридопиразиндионы - Google Patents

Циклопропанбензофуранилпиридопиразиндионы

Info

Publication number
EA033423B1
EA033423B1 EA201700356A EA201700356A EA033423B1 EA 033423 B1 EA033423 B1 EA 033423B1 EA 201700356 A EA201700356 A EA 201700356A EA 201700356 A EA201700356 A EA 201700356A EA 033423 B1 EA033423 B1 EA 033423B1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyridopyrazinediones
cyclopropabenzofuranyl
compounds
disclosed
methods
Prior art date
Application number
EA201700356A
Other languages
English (en)
Other versions
EA201700356A1 (ru
Inventor
Martin Youngjin Pettersson
Ende Christopher William Am
Douglas Scott Johnson
Gregory Wayne Kauffman
Antonia Friederike Stepan
Patrick Robert Verhoest
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of EA201700356A1 publication Critical patent/EA201700356A1/ru
Publication of EA033423B1 publication Critical patent/EA033423B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Раскрытыми являются соединения и фармацевтически приемлемые соли соединений, где соединения имеют структурную формулу IIгде R, R, R, R, R, R, R, Rи Rявляются такими, как описано в описании. Кроме того, описывается соответствующая фармацевтическая композиция, способы лечения, способы синтеза и промежуточные соединения.
EA201700356A 2015-02-03 2016-01-26 Циклопропанбензофуранилпиридопиразиндионы EA033423B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562111222P 2015-02-03 2015-02-03
PCT/IB2016/050384 WO2016125048A1 (en) 2015-02-03 2016-01-26 Novel cyclopropabenzofuranyl pyridopyrazinediones

Publications (2)

Publication Number Publication Date
EA201700356A1 EA201700356A1 (ru) 2018-01-31
EA033423B1 true EA033423B1 (ru) 2019-10-31

Family

ID=55299692

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201700356A EA033423B1 (ru) 2015-02-03 2016-01-26 Циклопропанбензофуранилпиридопиразиндионы

Country Status (22)

Country Link
US (2) US20160222007A1 (ru)
EP (1) EP3253755B1 (ru)
JP (1) JP6628805B2 (ru)
KR (1) KR102000382B1 (ru)
CN (1) CN107406445B (ru)
AR (1) AR103582A1 (ru)
AU (1) AU2016214102B2 (ru)
BR (1) BR112017015693A2 (ru)
CA (1) CA2919338A1 (ru)
DK (1) DK3253755T3 (ru)
EA (1) EA033423B1 (ru)
EC (1) ECSP17050310A (ru)
ES (1) ES2818806T3 (ru)
IL (1) IL253635A0 (ru)
MX (1) MX368391B (ru)
PE (1) PE20171318A1 (ru)
PH (1) PH12017501369A1 (ru)
SG (1) SG11201705780PA (ru)
TN (1) TN2017000342A1 (ru)
TW (1) TWI616445B (ru)
UY (1) UY36546A (ru)
WO (1) WO2016125048A1 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102271305B1 (ko) 2020-05-21 2021-06-30 주식회사 아리바이오 치매 예방 및 치료용 조성물
CN111978324A (zh) * 2020-08-28 2020-11-24 开封康诺药业有限公司 一种多索茶碱的晶型及其制备方法
KR102272907B1 (ko) 2020-11-05 2021-07-05 주식회사 아리바이오 치매 예방 및 치료용 조성물
KR102272910B1 (ko) 2021-01-28 2021-07-06 주식회사 아리바이오 당뇨병을 동반한 치매 예방 및 치료용 조성물
KR102311224B1 (ko) * 2021-04-23 2021-10-13 주식회사 아리바이오 Pde5 억제제와 글루코코르티코이드 수용체 길항제 병용투여를 통한 치매 예방 및 치료용 조성물

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