NZ767083A - Polymorphs of selinexor - Google Patents
Polymorphs of selinexorInfo
- Publication number
- NZ767083A NZ767083A NZ767083A NZ76708315A NZ767083A NZ 767083 A NZ767083 A NZ 767083A NZ 767083 A NZ767083 A NZ 767083A NZ 76708315 A NZ76708315 A NZ 76708315A NZ 767083 A NZ767083 A NZ 767083A
- Authority
- NZ
- New Zealand
- Prior art keywords
- structural formula
- crystalline forms
- compound
- compositions
- selinexor
- Prior art date
Links
- DEVSOMFAQLZNKR-RJRFIUFISA-N (z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-n'-pyrazin-2-ylprop-2-enehydrazide Chemical compound FC(F)(F)C1=CC(C(F)(F)F)=CC(C2=NN(\C=C/C(=O)NNC=3N=CC=NC=3)C=N2)=C1 DEVSOMFAQLZNKR-RJRFIUFISA-N 0.000 title 1
- 229950010613 selinexor Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000000203 mixture Substances 0.000 abstract 2
- 101100004408 Arabidopsis thaliana BIG gene Proteins 0.000 abstract 1
- 101100485279 Drosophila melanogaster emb gene Proteins 0.000 abstract 1
- 102100029095 Exportin-1 Human genes 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 101100485284 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) CRM1 gene Proteins 0.000 abstract 1
- 101150094313 XPO1 gene Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 108700002148 exportin 1 Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to crystalline forms of the compound represented by Structural Formula I, and compositions comprising crystalline forms of the compound represented by Structural Formula I described herein. The crystalline forms of the compound of Structural Formula I and compositions comprising the crystalline forms of the compound of Structural Formula I provided herein, in particular, single crystalline Form A, can be incorporated into pharmaceutical compositions, which can be used to treat various disorders associated with CRM1 activity, including cancer. Also described herein are methods for preparing the compound of Structural Formula I and its single crystalline forms.
Claims (1)
1.Claims e
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462038069P | 2014-08-15 | 2014-08-15 | |
| NZ728850A NZ728850B2 (en) | 2015-08-14 | Polymorphs of selinexor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NZ767083A true NZ767083A (en) | 2024-02-23 |
| NZ767083B2 NZ767083B2 (en) | 2024-05-24 |
Family
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 14 AUG 2025 BY COMPUTER PACKAGES INC Effective date: 20240817 |