MD20160102A2 - Cromen şi 1,1a,2,7b-tetrahidrociclopropa[c]cromen piridopirazindione ca modulatori ai gama-secretazei - Google Patents
Cromen şi 1,1a,2,7b-tetrahidrociclopropa[c]cromen piridopirazindione ca modulatori ai gama-secretazeiInfo
- Publication number
- MD20160102A2 MD20160102A2 MDA20160102A MD20160102A MD20160102A2 MD 20160102 A2 MD20160102 A2 MD 20160102A2 MD A20160102 A MDA20160102 A MD A20160102A MD 20160102 A MD20160102 A MD 20160102A MD 20160102 A2 MD20160102 A2 MD 20160102A2
- Authority
- MD
- Moldova
- Prior art keywords
- chromene
- pyridopyrazinediones
- tetrahydrocyclopropa
- gamma
- secretase modulators
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Sunt dezvăluiţi compuşi cu Formula I şi sărurile farmaceutic acceptabile ale acestoraunde X, R1, R2a, R2b, R4a, R4b, R5a, R5b, R6, R7, y şi z sunt aşa cum sunt definiţi în descriere. Sunt de asemenea dezvăluite compoziţii farmaceutice, metode de tratament, metode de sinteză şi produşi intermediari. Aceşti compuşi au proprietăţi de modulatori ai γ-secretazei şi pot fi utili în tratamentul maladiilor neurodegenerative şi/sau neurologice, aşa ca boala Alzheimer şi sindromul Down.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461973436P | 2014-04-01 | 2014-04-01 | |
PCT/IB2015/051988 WO2015150957A1 (en) | 2014-04-01 | 2015-03-18 | Chromene and 1,1 a,2,7b-tetrahydrocyclopropa[c]chromene pyridopyrazinediones as gamma-secretase modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
MD20160102A2 true MD20160102A2 (ro) | 2017-04-30 |
Family
ID=52815058
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDA20160102A MD20160102A2 (ro) | 2014-04-01 | 2015-03-18 | Cromen şi 1,1a,2,7b-tetrahidrociclopropa[c]cromen piridopirazindione ca modulatori ai gama-secretazei |
Country Status (30)
Country | Link |
---|---|
US (2) | US20150274721A1 (ro) |
EP (1) | EP3126361B1 (ro) |
JP (1) | JP6643247B2 (ro) |
KR (1) | KR101886945B1 (ro) |
CN (1) | CN106211770B (ro) |
AP (1) | AP2016009465A0 (ro) |
AR (1) | AR099874A1 (ro) |
AU (1) | AU2015242330B2 (ro) |
BR (1) | BR112016022519A8 (ro) |
CA (1) | CA2944308A1 (ro) |
CL (1) | CL2016002422A1 (ro) |
CR (1) | CR20160454A (ro) |
CU (1) | CU20160140A7 (ro) |
DK (1) | DK3126361T3 (ro) |
DO (1) | DOP2016000266A (ro) |
EA (1) | EA031419B1 (ro) |
EC (1) | ECSP16078289A (ro) |
ES (1) | ES2759277T3 (ro) |
HK (1) | HK1231481A1 (ro) |
IL (1) | IL248154B (ro) |
MD (1) | MD20160102A2 (ro) |
MX (1) | MX369074B (ro) |
NI (1) | NI201600149A (ro) |
PE (1) | PE20161364A1 (ro) |
PH (1) | PH12016501864A1 (ro) |
SG (1) | SG11201607465UA (ro) |
TW (1) | TWI568733B (ro) |
UY (1) | UY36054A (ro) |
WO (1) | WO2015150957A1 (ro) |
ZA (1) | ZA201606252B (ro) |
Families Citing this family (10)
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UA110688C2 (uk) | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
WO2016125048A1 (en) * | 2015-02-03 | 2016-08-11 | Pfizer Inc. | Novel cyclopropabenzofuranyl pyridopyrazinediones |
CN106580997B (zh) * | 2016-12-09 | 2018-01-19 | 张田 | 一种治疗先兆流产的药物组合物 |
KR20190098998A (ko) | 2016-12-16 | 2019-08-23 | 파이프라인 테라퓨틱스, 아이엔씨. | 달팽이관 시냅스질환의 치료 방법 |
KR102672512B1 (ko) * | 2018-09-12 | 2024-06-10 | 노파르티스 아게 | 항바이러스 피리도피라진디온 화합물 |
CN110907542A (zh) * | 2018-09-17 | 2020-03-24 | 复旦大学 | 一种液质联用检测唾液中司来吉兰及其代谢物的方法 |
JP7413346B2 (ja) | 2019-03-06 | 2024-01-15 | 第一三共株式会社 | ピロロピラゾール誘導体 |
JP7417715B2 (ja) | 2019-09-26 | 2024-01-18 | ノバルティス アーゲー | 抗ウイルスピラゾロピリジノン化合物 |
WO2024084363A1 (en) | 2022-10-18 | 2024-04-25 | Pfizer Inc. | Use of patatin-like phospholipase domain-containing protein 3 compounds |
WO2024084360A1 (en) | 2022-10-18 | 2024-04-25 | Pfizer Inc. | Patatin-like phospholipase domain-containing protein 3 (pnpla3) modifiers |
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-
2015
- 2015-03-18 AU AU2015242330A patent/AU2015242330B2/en not_active Ceased
- 2015-03-18 PE PE2016001895A patent/PE20161364A1/es not_active Application Discontinuation
- 2015-03-18 DK DK15714951.9T patent/DK3126361T3/da active
- 2015-03-18 EA EA201600619A patent/EA031419B1/ru not_active IP Right Cessation
- 2015-03-18 BR BR112016022519A patent/BR112016022519A8/pt not_active IP Right Cessation
- 2015-03-18 SG SG11201607465UA patent/SG11201607465UA/en unknown
- 2015-03-18 CA CA2944308A patent/CA2944308A1/en not_active Withdrawn
- 2015-03-18 JP JP2016559879A patent/JP6643247B2/ja not_active Expired - Fee Related
- 2015-03-18 MX MX2016012904A patent/MX369074B/es active IP Right Grant
- 2015-03-18 CN CN201580018466.7A patent/CN106211770B/zh not_active Expired - Fee Related
- 2015-03-18 EP EP15714951.9A patent/EP3126361B1/en active Active
- 2015-03-18 MD MDA20160102A patent/MD20160102A2/ro not_active Application Discontinuation
- 2015-03-18 CR CR20160454A patent/CR20160454A/es unknown
- 2015-03-18 WO PCT/IB2015/051988 patent/WO2015150957A1/en active Application Filing
- 2015-03-18 ES ES15714951T patent/ES2759277T3/es active Active
- 2015-03-18 KR KR1020167030135A patent/KR101886945B1/ko active IP Right Grant
- 2015-03-18 AP AP2016009465A patent/AP2016009465A0/en unknown
- 2015-03-27 AR ARP150100922A patent/AR099874A1/es unknown
- 2015-03-27 US US14/670,746 patent/US20150274721A1/en not_active Abandoned
- 2015-03-27 UY UY0001036054A patent/UY36054A/es not_active Application Discontinuation
- 2015-03-31 TW TW104110551A patent/TWI568733B/zh not_active IP Right Cessation
-
2016
- 2016-09-09 ZA ZA2016/06252A patent/ZA201606252B/en unknown
- 2016-09-22 CU CUP2016000140A patent/CU20160140A7/es unknown
- 2016-09-22 PH PH12016501864A patent/PH12016501864A1/en unknown
- 2016-09-27 CL CL2016002422A patent/CL2016002422A1/es unknown
- 2016-09-29 IL IL248154A patent/IL248154B/en active IP Right Grant
- 2016-09-29 DO DO2016000266A patent/DOP2016000266A/es unknown
- 2016-09-29 NI NI201600149A patent/NI201600149A/es unknown
- 2016-09-30 EC ECIEPI201678289A patent/ECSP16078289A/es unknown
-
2017
- 2017-02-24 US US15/441,882 patent/US20170166566A1/en not_active Abandoned
- 2017-05-24 HK HK17105246.2A patent/HK1231481A1/zh not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA9A | Abandonment or withdrawal of application (patent for invention) |