CL2016002422A1 - Cromeno y 1, 1a,2,7b-tetrahidrociclopropa[c]cromeno piridopirazinadionas como moduladores de gamma-secretasas. - Google Patents

Cromeno y 1, 1a,2,7b-tetrahidrociclopropa[c]cromeno piridopirazinadionas como moduladores de gamma-secretasas.

Info

Publication number
CL2016002422A1
CL2016002422A1 CL2016002422A CL2016002422A CL2016002422A1 CL 2016002422 A1 CL2016002422 A1 CL 2016002422A1 CL 2016002422 A CL2016002422 A CL 2016002422A CL 2016002422 A CL2016002422 A CL 2016002422A CL 2016002422 A1 CL2016002422 A1 CL 2016002422A1
Authority
CL
Chile
Prior art keywords
chromene
modulators
gamma
pyridopyrazinadiones
tetrahydrocyclopropa
Prior art date
Application number
CL2016002422A
Other languages
English (en)
Inventor
John Michael Humphrey
Patrick Robert Verhoest
Ende Christopher William Am
Douglas Scott Johnson
Gregory Wayne Kauffman
Martin Youngjin Pettersson
Danica Antonia Rankic
Antonio Friederike Stepan
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52815058&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2016002422(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of CL2016002422A1 publication Critical patent/CL2016002422A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

<p>COMPUESTOS DERIVADOS DE CROMENO Y 1, 1A,2,7B-TETRAHIDROCICLOPROPA[C]CROMENO PIRIDOPIRAZINADIONAS, MODULADORES DE GAMMA-SECRETASAS; COMPOSICION FARMACEUTICA; Y USO EN EL TRATAMIENTO DE LA ENFEMRMEDAD DE ALZHEIMER</p>
CL2016002422A 2014-04-01 2016-09-27 Cromeno y 1, 1a,2,7b-tetrahidrociclopropa[c]cromeno piridopirazinadionas como moduladores de gamma-secretasas. CL2016002422A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461973436P 2014-04-01 2014-04-01

Publications (1)

Publication Number Publication Date
CL2016002422A1 true CL2016002422A1 (es) 2017-02-03

Family

ID=52815058

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016002422A CL2016002422A1 (es) 2014-04-01 2016-09-27 Cromeno y 1, 1a,2,7b-tetrahidrociclopropa[c]cromeno piridopirazinadionas como moduladores de gamma-secretasas.

Country Status (30)

Country Link
US (2) US20150274721A1 (es)
EP (1) EP3126361B1 (es)
JP (1) JP6643247B2 (es)
KR (1) KR101886945B1 (es)
CN (1) CN106211770B (es)
AP (1) AP2016009465A0 (es)
AR (1) AR099874A1 (es)
AU (1) AU2015242330B2 (es)
BR (1) BR112016022519A8 (es)
CA (1) CA2944308A1 (es)
CL (1) CL2016002422A1 (es)
CR (1) CR20160454A (es)
CU (1) CU20160140A7 (es)
DK (1) DK3126361T3 (es)
DO (1) DOP2016000266A (es)
EA (1) EA031419B1 (es)
EC (1) ECSP16078289A (es)
ES (1) ES2759277T3 (es)
HK (1) HK1231481A1 (es)
IL (1) IL248154B (es)
MD (1) MD20160102A2 (es)
MX (1) MX369074B (es)
NI (1) NI201600149A (es)
PE (1) PE20161364A1 (es)
PH (1) PH12016501864A1 (es)
SG (1) SG11201607465UA (es)
TW (1) TWI568733B (es)
UY (1) UY36054A (es)
WO (1) WO2015150957A1 (es)
ZA (1) ZA201606252B (es)

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JP6904612B2 (ja) 2016-12-16 2021-07-21 パイプライン セラピューティクス， インコーポレイテッド 蝸牛シナプス障害を処置する方法
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EP3936192A4 (en) 2019-03-06 2022-11-16 Daiichi Sankyo Company, Limited PYRROLOPYRAZOL DERIVATIVES
CA3155287A1 (en) 2019-09-26 2021-04-01 Novartis Ag Antiviral pyrazolopyridinone compounds
WO2024084363A1 (en) 2022-10-18 2024-04-25 Pfizer Inc. Use of patatin-like phospholipase domain-containing protein 3 compounds
WO2024084360A1 (en) 2022-10-18 2024-04-25 Pfizer Inc. Patatin-like phospholipase domain-containing protein 3 (pnpla3) modifiers

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Also Published As

Publication number Publication date
AR099874A1 (es) 2016-08-24
PE20161364A1 (es) 2016-12-25
UY36054A (es) 2015-10-30
JP6643247B2 (ja) 2020-02-12
AP2016009465A0 (en) 2016-09-30
ZA201606252B (en) 2018-05-30
EA031419B1 (ru) 2018-12-28
US20150274721A1 (en) 2015-10-01
MX369074B (es) 2019-10-28
HK1231481A1 (zh) 2017-12-22
JP2017512803A (ja) 2017-05-25
TWI568733B (zh) 2017-02-01
BR112016022519A8 (pt) 2018-03-06
MD20160102A2 (ro) 2017-04-30
DK3126361T3 (da) 2020-01-02
IL248154B (en) 2020-09-30
PH12016501864A1 (en) 2016-12-19
WO2015150957A1 (en) 2015-10-08
KR20160137635A (ko) 2016-11-30
CN106211770B (zh) 2018-02-06
EA201600619A1 (ru) 2017-03-31
US20170166566A1 (en) 2017-06-15
CA2944308A1 (en) 2015-10-08
DOP2016000266A (es) 2016-11-15
BR112016022519A2 (pt) 2017-08-15
CU20160140A7 (es) 2017-02-02
IL248154A0 (en) 2016-11-30
CN106211770A (zh) 2016-12-07
EP3126361A1 (en) 2017-02-08
NI201600149A (es) 2016-11-18
ECSP16078289A (es) 2017-02-24
AU2015242330A1 (en) 2016-09-22
TW201540716A (zh) 2015-11-01
KR101886945B1 (ko) 2018-08-08
AU2015242330B2 (en) 2017-08-17
CR20160454A (es) 2016-12-06
MX2016012904A (es) 2016-12-07
ES2759277T3 (es) 2020-05-08
EP3126361B1 (en) 2019-11-06
SG11201607465UA (en) 2016-10-28

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