CL2016002735A1 - Compuestos de imidazo[4,5-c]quinolin-2-ona y su uso para tratar cáncer - Google Patents

Compuestos de imidazo[4,5-c]quinolin-2-ona y su uso para tratar cáncer

Info

Publication number
CL2016002735A1
CL2016002735A1 CL2016002735A CL2016002735A CL2016002735A1 CL 2016002735 A1 CL2016002735 A1 CL 2016002735A1 CL 2016002735 A CL2016002735 A CL 2016002735A CL 2016002735 A CL2016002735 A CL 2016002735A CL 2016002735 A1 CL2016002735 A1 CL 2016002735A1
Authority
CL
Chile
Prior art keywords
quinolin
imidazo
compounds
treat cancer
ona
Prior art date
Application number
CL2016002735A
Other languages
English (en)
Inventor
Bernard Christophe Barlaam
Kurt Gordon Pike
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CL2016002735A1 publication Critical patent/CL2016002735A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

<p>COMPUESTOS DERIVADOS DE IMIDAZO[4,5-C]QUINOLIN-2-ONA; COMPOSICIÓN FARMACÉUTICA Y SU USO PARA TRATAR EL CÁNCER.</p>
CL2016002735A 2014-05-08 2016-10-27 Compuestos de imidazo[4,5-c]quinolin-2-ona y su uso para tratar cáncer CL2016002735A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461990232P 2014-05-08 2014-05-08

Publications (1)

Publication Number Publication Date
CL2016002735A1 true CL2016002735A1 (es) 2017-02-10

Family

ID=53264681

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016002735A CL2016002735A1 (es) 2014-05-08 2016-10-27 Compuestos de imidazo[4,5-c]quinolin-2-ona y su uso para tratar cáncer

Country Status (38)

Country Link
US (4) US9428503B2 (es)
EP (1) EP3140303B1 (es)
JP (1) JP6505131B2 (es)
KR (1) KR102013021B1 (es)
CN (1) CN106255692B (es)
AP (1) AP2016009532A0 (es)
AR (1) AR100340A1 (es)
AU (1) AU2015257456B2 (es)
CA (1) CA2946459C (es)
CL (1) CL2016002735A1 (es)
CR (1) CR20160523A (es)
CY (1) CY1120248T1 (es)
DK (1) DK3140303T3 (es)
DO (1) DOP2016000281A (es)
EA (1) EA031674B1 (es)
ES (1) ES2670416T3 (es)
HR (1) HRP20180697T1 (es)
HU (1) HUE037558T2 (es)
IL (1) IL248397B (es)
LT (1) LT3140303T (es)
MA (1) MA39960A (es)
MX (1) MX2016014639A (es)
NI (1) NI201600166A (es)
NO (1) NO2714752T3 (es)
NZ (1) NZ726042A (es)
PE (1) PE20170403A1 (es)
PH (1) PH12016502168A1 (es)
PL (1) PL3140303T3 (es)
PT (1) PT3140303T (es)
RS (1) RS57223B1 (es)
SG (1) SG11201609164VA (es)
SI (1) SI3140303T1 (es)
SV (1) SV2016005312A (es)
TN (1) TN2016000458A1 (es)
TR (1) TR201807101T4 (es)
TW (1) TWI662034B (es)
UY (1) UY36112A (es)
WO (1) WO2015170081A1 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107889488B (zh) * 2015-04-02 2020-08-11 默克专利股份公司 咪唑酮基喹啉和其作为atm激酶抑制剂的用途
GB201516504D0 (en) 2015-09-17 2015-11-04 Astrazeneca Ab Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer
GB201519406D0 (en) * 2015-11-03 2015-12-16 Astrazeneca Ab Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
GB201519568D0 (en) * 2015-11-05 2015-12-23 Astrazeneca Ab Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
US20190099421A1 (en) * 2016-03-21 2019-04-04 Astrazeneca Ab Cinnolin-4-amine compounds and their use in treating cancer
KR20180132804A (ko) 2016-04-07 2018-12-12 아스트라제네카 아베 암 치료를 위한 atm(모세관확장실조 돌연변이) 키나제 조정자로서의 n,n-디메틸-3-[[5-(3-메틸-2-옥소-1-테트라하이드로피란-4-일-이미다조[4,5-c]퀴놀린-8-일)-2-피리딜]옥시]프로판-1-아민 옥시드
GB201608227D0 (en) * 2016-05-11 2016-06-22 Astrazeneca Ab Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
JOP20190151B1 (ar) 2016-12-20 2023-09-17 Astrazeneca Ab مركبات أمينو - ترايازولو بيريدين واستخدامها في علاج سرطان
CA3049608A1 (en) * 2017-01-09 2018-07-12 Suixiong Cai Substituted fused heteroaromatic compounds as kinase inhibitors and the use thereof
CN106798741A (zh) * 2017-02-07 2017-06-06 宫英 一种治疗抑郁症的药物组合物
CN106692147A (zh) * 2017-02-07 2017-05-24 李明英 一种治疗男性不育的药物组合物
CN106822123A (zh) * 2017-02-09 2017-06-13 王艳苓 一种治疗心脑血管疾病的药物组合物
US11547703B2 (en) 2017-02-27 2023-01-10 Impact Therapeutics (Shanghai), Inc Substituted fused heteroaromatic tricyclic compounds as kinase inhibitors and the use thereof
JOP20190209A1 (ar) * 2017-03-16 2019-09-12 Astrazeneca Ab مركبات إيميدازو [ 4، 5-c ] كينولين-2-أون ديوترومية واستخدامها في علاج السرطان
WO2019057757A1 (en) 2017-09-20 2019-03-28 Astrazeneca Ab 1,3-DIHYDROIMIDAZO [4,5-C] CINNOLIN-2-ONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER
WO2019201283A1 (en) * 2018-04-20 2019-10-24 Xrad Therapeutics, Inc. Dual atm and dna-pk inhibitors for use in anti-tumor therapy
CN110386932A (zh) * 2018-04-20 2019-10-29 艾科思莱德制药公司 用于抗肿瘤疗法中的双重atm和dna-pk抑制剂
CN112752758B (zh) * 2018-09-14 2023-05-23 苏州赞荣医药科技有限公司 作为ATM激酶选择性调节剂的咪唑并[4,5-c]噌啉-2-酮化合物及其用途
CA3116234A1 (en) * 2018-10-15 2020-04-23 Merck Patent Gmbh Combination therapy utilizing dna alkylating agents and atr inhibitors
PE20220140A1 (es) * 2019-03-05 2022-01-27 Astrazeneca Ab Compuestos triciclicos condensados utiles como agentes anticancerigenos
TW202102497A (zh) * 2019-03-29 2021-01-16 瑞典商阿斯特捷利康公司 化合物及它們在治療癌症中之用途
CN111909147B (zh) * 2019-05-10 2021-07-20 山东轩竹医药科技有限公司 Dna-pk抑制剂
WO2021004482A1 (zh) * 2019-07-10 2021-01-14 上海瑛派药业有限公司 取代的吡唑并喹唑啉酮化合物及其应用
CA3149883A1 (en) * 2019-09-12 2021-03-18 Sui Xiong Cai Substituted imidazoquinoxaline compounds and uses thereof
CN115003672A (zh) * 2020-01-09 2022-09-02 南京明德新药研发有限公司 喹啉并咪唑类化合物及其应用
CN114980900A (zh) * 2020-01-13 2022-08-30 上海华禹生物科技有限公司 N2-喹啉或异喹啉取代的嘌呤衍生物在癌症治疗中的用途
EP4171651A1 (en) 2020-06-24 2023-05-03 AstraZeneca UK Limited Combination of antibody-drug conjugate and atm inhibitor
EP3992191A1 (en) 2020-11-03 2022-05-04 Deutsches Krebsforschungszentrum Imidazo[4,5-c]quinoline compounds and their use as atm kinase inhibitors
AU2021433713A1 (en) * 2021-03-17 2023-09-28 Suzhou Zanrong Pharma Limited Selective modulators of ataxia telangiectasia mutated (atm) kinase and uses thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0211649D0 (en) * 2002-05-21 2002-07-03 Novartis Ag Organic compounds
JP2007511575A (ja) 2003-11-21 2007-05-10 ノバルティス アクチエンゲゼルシャフト タンパク質キナーゼ阻害剤としての１ｈ−イミダゾキノリン誘導体
GB0510390D0 (en) * 2005-05-20 2005-06-29 Novartis Ag Organic compounds
PE20090717A1 (es) * 2007-05-18 2009-07-18 Smithkline Beecham Corp Derivados de quinolina como inhibidores de la pi3 quinasa
RU2509078C2 (ru) 2008-07-01 2014-03-10 Дженентек, Инк. Бициклические гетероциклы в качестве ингибиторов киназы мек
ES2614130T3 (es) 2008-09-30 2017-05-29 Pfizer Inc. Compuestos de imidazo[1,5]naftiridina, su uso farmacéutico y composiciones
TW201041888A (en) * 2009-05-06 2010-12-01 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
US20100311714A1 (en) * 2009-06-04 2010-12-09 Pascal Furet 1H-IMIDAZO[4,5-c]QUINOLINONE COMPOUNDS
UA106074C2 (uk) 2009-06-04 2014-07-25 Новартіс Аг ПОХІДНІ 1H-ІМІДАЗО[4,5-c]ХІНОЛІНОНУ
NZ599090A (en) * 2009-09-28 2014-02-28 Hoffmann La Roche Benzoxepin pi3k inhibitor compounds and methods of use
GB0919423D0 (en) 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds
CN102199152A (zh) 2010-03-25 2011-09-28 高大新 杂环咪唑类磷脂激酶抑制剂
CN102372711B (zh) 2010-08-18 2014-09-17 山东轩竹医药科技有限公司 咪唑并喹啉类PI3K和mTOR双重抑制剂
US20130149094A1 (en) 2010-08-26 2013-06-13 Hitachi Construction Machinery Co., Ltd. Construction machine
DE102010035744A1 (de) 2010-08-28 2012-03-01 Merck Patent Gmbh Imidazolonylchinoline
CN102399218A (zh) * 2010-09-16 2012-04-04 和记黄埔医药（上海）有限公司 一类并合三杂环及其作为pi3k抑制剂的用途
CN103402520A (zh) 2010-12-06 2013-11-20 皮拉马尔企业有限公司 具有取代基的咪唑并喹啉衍生物
AU2012240246A1 (en) 2011-04-04 2013-05-09 Netherlands Cancer Institute Methods and compositions for predicting resistance to anticancer treatment with protein kinase inhibitors
JP6042060B2 (ja) * 2011-09-26 2016-12-14 サノフイ ピラゾロキノリノン誘導体、その調製および治療上の使用

Also Published As

Publication number Publication date
AR100340A1 (es) 2016-09-28
CN106255692B (zh) 2019-02-26
LT3140303T (lt) 2018-05-25
TR201807101T4 (tr) 2018-06-21
EA031674B1 (ru) 2019-02-28
SV2016005312A (es) 2017-03-16
US10189834B2 (en) 2019-01-29
JP6505131B2 (ja) 2019-04-24
CY1120248T1 (el) 2019-07-10
HRP20180697T1 (hr) 2018-06-01
EP3140303A1 (en) 2017-03-15
CR20160523A (es) 2017-04-27
KR102013021B1 (ko) 2019-08-21
SG11201609164VA (en) 2016-12-29
TN2016000458A1 (en) 2018-04-04
AU2015257456B2 (en) 2018-02-15
PL3140303T3 (pl) 2018-08-31
ES2670416T3 (es) 2018-05-30
DOP2016000281A (es) 2016-12-15
US9428503B2 (en) 2016-08-30
US9822111B2 (en) 2017-11-21
CA2946459C (en) 2022-07-12
EA201692095A1 (ru) 2017-08-31
PT3140303T (pt) 2018-05-25
DK3140303T3 (en) 2018-06-06
US20160368920A1 (en) 2016-12-22
PH12016502168B1 (en) 2016-12-19
PH12016502168A1 (en) 2016-12-19
NZ726042A (en) 2018-08-31
RS57223B1 (sr) 2018-07-31
TWI662034B (zh) 2019-06-11
PE20170403A1 (es) 2017-05-07
SI3140303T1 (en) 2018-06-29
KR20160147054A (ko) 2016-12-21
MA39960A (fr) 2018-03-28
US20150336952A1 (en) 2015-11-26
IL248397B (en) 2019-02-28
UY36112A (es) 2015-10-30
WO2015170081A1 (en) 2015-11-12
CA2946459A1 (en) 2015-11-12
NO2714752T3 (es) 2018-04-21
AP2016009532A0 (en) 2016-11-30
JP2017514877A (ja) 2017-06-08
NI201600166A (es) 2017-03-13
MX2016014639A (es) 2017-03-06
AU2015257456A1 (en) 2016-11-24
BR112016025153A8 (pt) 2021-07-20
EP3140303B1 (en) 2018-03-28
US20180134699A1 (en) 2018-05-17
CN106255692A (zh) 2016-12-21
TW201625609A (zh) 2016-07-16
HUE037558T2 (hu) 2018-09-28
BR112016025153A2 (pt) 2017-08-15
US20190185468A1 (en) 2019-06-20

Similar Documents

Publication Publication Date Title
CL2016002735A1 (es) Compuestos de imidazo[4,5-c]quinolin-2-ona y su uso para tratar cáncer
CL2018001171A1 (es) Compuestos de imidazo[4,5-c]quinolin-2-ona y su uso en el tratamiento del cáncer
CL2016002027A1 (es) Ciclopropilamina como inhibidor de la lsd1
DOP2017000176A (es) Derivados de 4h-pirrol[3,2-c]piridin-4-ona
CL2018002012A1 (es) Derivados de maitansinoide, conjugados de los mismos y métodos de uso.
CL2016000153A1 (es) Derivados de pirrolamida sustituidos con glioxamida y su uso como medicamentos para el tratamiento de la hepatitis b
ECSP17016797A (es) Indazoles sustituidos con benzilo como inhibidores de bub1
CO2017005784A2 (es) Compuestos bicíclicos fusionados para el tratamiento de enfermedades
CL2016001895A1 (es) Compuestos
CL2015001985A1 (es) Compuestos de tiazolcarboxamidas y piridinacarboxamida, inhibidores de quinasa pim.
CL2014002873A1 (es) Compuestos derivados de pirimidin-amina o triazin-amina, inhibidores de adn-pk; composicion farmaceutica; y su uso para el tratamiento del cancer.
CL2016000922A1 (es) Derivados de anillo bicíclico fusionado piridilo como inhibidores fgfr4
CL2016001737A1 (es) Derivados heterocíclicos bicíclicos como inhibidores de bromodominio
CL2015002932A1 (es) Inhibidores de proteína quinasa
MX2016016666A (es) Derivados de acido boronico y usos terapeuticos de los mismos.
CO2017007121A2 (es) Compuestos bicíclicos fusionados para el tratamiento de enfermedades
MX2016015093A (es) Derivados de acido boronico y sus usos terapeuticos.
BR112016015706A2 (pt) composto, uso do mesmo e composição farmacêutica
CL2015002635A1 (es) Compuestos y composiciones para el tratamiento de enfermedades parasitarias
CL2016003074A1 (es) Compuestos derivados de 2-oxi-2-fenil-n-5-pirrolidin-3-ilamino-1,3,4-tiadiazol-2-ilacetamida, inhibidores gls1 composición farmacéutica y su uso para tratar el cáncer.
CL2016002091A1 (es) Compuesto de triazina y su uso para fines medicinales
CL2016001937A1 (es) Compuestos de benzopirano funcionalizados y uso de los mismos
CL2015002897A1 (es) Inhibidores de bace1
BR112018010279A2 (pt) novos anticorpos anti-emr2 e métodos de uso
CL2016002151A1 (es) Derivados de piridazina para uso en la prevención o el tratamiento de un trastorno atáxico