UA106074C2 - ПОХІДНІ 1H-ІМІДАЗО[4,5-c]ХІНОЛІНОНУ - Google Patents

ПОХІДНІ 1H-ІМІДАЗО[4,5-c]ХІНОЛІНОНУ

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Publication number
UA106074C2
UA106074C2 UAA201114398A UAA201114398A UA106074C2 UA 106074 C2 UA106074 C2 UA 106074C2 UA A201114398 A UAA201114398 A UA A201114398A UA A201114398 A UAA201114398 A UA A201114398A UA 106074 C2 UA106074 C2 UA 106074C2
Authority
UA
Ukraine
Prior art keywords
imidazo
quinolinone derivatives
treatment
quinolinone
diseases
Prior art date
Application number
UAA201114398A
Other languages
English (en)
Russian (ru)
Inventor
Паскаль Фуре
Франк Стефан Калтхофф
Роберт Мах
Крістіан Раго
Фредерік Штауффер
Original Assignee
Новартіс Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42697442&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA106074(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Новартіс Аг filed Critical Новартіс Аг
Publication of UA106074C2 publication Critical patent/UA106074C2/uk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

В заявці описані застосування похідних 1Н-імідазо[4,5-с]хінолінону та їх солей для лікування захворювань, залежних від протеїн- та/або ліпідкінази, та для приготування фармацевтичних препаратів, призначених для лікування таких захворювань; похідні 1Н-імідазо[4,5-с]хінолінону, призначені для застосування для лікування захворювань, залежних від протеїн- та/або ліпідкінази; спосіб лікування зазначених захворювань, що включає введення похідних 1H-імідазо[4,5-с]хінолінону теплокровній тварині, переважно людині; фармацевтичні препарати, що містять похідну 1Н-імідазо[4,5-с]хінолінону, переважно призначені для лікування захворювання, залежного від протеїн- та/або ліпідкінази; нові похідні 1Н-імідазо[4,5-с]хінолінону та спосіб одержання нових похідних 1Н-імідазо[4,5-с]хінолінону.
UAA201114398A 2009-06-04 2010-06-02 ПОХІДНІ 1H-ІМІДАЗО[4,5-c]ХІНОЛІНОНУ UA106074C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18414109P 2009-06-04 2009-06-04
PCT/EP2010/057719 WO2010139731A1 (en) 2009-06-04 2010-06-02 1H-IMIDAZO[4,5-c]QUINOLINONE DERIVATIVES

Publications (1)

Publication Number Publication Date
UA106074C2 true UA106074C2 (uk) 2014-07-25

Family

ID=42697442

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201114398A UA106074C2 (uk) 2009-06-04 2010-06-02 ПОХІДНІ 1H-ІМІДАЗО[4,5-c]ХІНОЛІНОНУ

Country Status (30)

Country Link
US (2) US8476294B2 (uk)
EP (1) EP2438064A1 (uk)
JP (1) JP5596137B2 (uk)
KR (1) KR101445458B1 (uk)
CN (1) CN102574845B (uk)
AR (1) AR076949A1 (uk)
AU (1) AU2010255727B2 (uk)
BR (1) BRPI1010621A2 (uk)
CA (1) CA2763821A1 (uk)
CL (1) CL2011003052A1 (uk)
CO (1) CO6470887A2 (uk)
CR (1) CR20110608A (uk)
CU (1) CU24064B1 (uk)
DO (1) DOP2011000373A (uk)
EA (1) EA020715B1 (uk)
EC (1) ECSP11011500A (uk)
GE (1) GEP20156267B (uk)
IL (1) IL216452A0 (uk)
MA (1) MA33332B1 (uk)
MX (1) MX2011012943A (uk)
NI (1) NI201100209A (uk)
NZ (1) NZ596487A (uk)
PE (1) PE20120224A1 (uk)
SG (1) SG176572A1 (uk)
TN (1) TN2011000626A1 (uk)
TW (1) TWI464168B (uk)
UA (1) UA106074C2 (uk)
UY (1) UY32682A (uk)
WO (1) WO2010139731A1 (uk)
ZA (1) ZA201108439B (uk)

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BR112013013837A2 (pt) * 2010-12-06 2016-09-13 Piramal Entpr Ltd derivados de substituição de imidazoquinolina
JO3003B1 (ar) 2011-01-14 2016-09-05 Lilly Co Eli مركب أيميدازو [4، 5 -c ] كينولين-2- واحد واستخدامه كمثبط كيناز PI3/mtor
EP2781520B1 (en) * 2011-11-17 2016-05-04 Xuanzhu Pharma Co., Ltd. Three-ring pi3k and/or mtor inhibitor
WO2014141118A1 (en) * 2013-03-14 2014-09-18 Piramal Enterprises Limited Imidazo[4,5-c]quinoline derivatives and uses thereof
US9730447B2 (en) 2013-04-15 2017-08-15 E I Du Pont De Nemours And Company Fungicidal amides
EP3044285A1 (de) * 2013-09-11 2016-07-20 Merck Patent GmbH Heterocyclische verbindungen
JP6441910B2 (ja) 2013-09-30 2018-12-19 シャンハイ インリ ファーマシューティカル カンパニー リミティド 縮合ピリミジン化合物、中間体、その調製方法、組成物及び使用
US10989719B2 (en) * 2013-10-11 2021-04-27 National University Corporation Tokyo Medical And Dental University Methods for treating spinocerebellar ataxia type I using RPA1
JP6290412B2 (ja) * 2013-11-20 2018-03-07 ベイジン フォーランドファルマ カンパニー リミテッド イミダゾロン系誘導体、その医薬組成物及び用途
NO2714752T3 (uk) 2014-05-08 2018-04-21
JP6195684B2 (ja) 2014-06-03 2017-09-13 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ ピラゾール化合物及びｔ型カルシウムチャンネルブロッカーとしてのそれらの使用
CA2981365A1 (en) * 2015-04-02 2016-10-06 Merck Patent Gmbh Imidazolonylquinolines and the use thereof as atm kinase inhibitors
GB201516504D0 (en) * 2015-09-17 2015-11-04 Astrazeneca Ab Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer
GB201519568D0 (en) * 2015-11-05 2015-12-23 Astrazeneca Ab Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
BR112019007594A2 (pt) 2016-10-13 2019-07-02 Loyola University Of Chicago método para bloquear a transmissão do parasita da malária
CN110072521B (zh) 2016-12-16 2022-11-29 爱杜西亚药品有限公司 包含t型钙通道阻断剂的药物组合
TWI808960B (zh) 2017-02-06 2023-07-21 瑞士商愛杜西亞製藥有限公司 用於合成1-芳基-1-三氟甲基環丙烷之新穎方法
JOP20190209A1 (ar) * 2017-03-16 2019-09-12 Astrazeneca Ab مركبات إيميدازو [ 4، 5-c ] كينولين-2-أون ديوترومية واستخدامها في علاج السرطان
IL275490B2 (en) 2017-12-22 2024-05-01 Ravenna Pharmaceuticals Inc Aminopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors
CN116056698A (zh) 2020-09-21 2023-05-02 钟卫 具有血脑屏障穿透能力的取代的1-(3,3-二氟哌啶-4-基)-咪唑并[4,5-c]喹啉-2-酮化合物

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GB0211649D0 (en) * 2002-05-21 2002-07-03 Novartis Ag Organic compounds
JP2007511575A (ja) 2003-11-21 2007-05-10 ノバルティス アクチエンゲゼルシャフト タンパク質キナーゼ阻害剤としての１ｈ−イミダゾキノリン誘導体
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Also Published As

Publication number Publication date
CU20110221A7 (es) 2012-03-15
AU2010255727A1 (en) 2011-12-08
US20100317657A1 (en) 2010-12-16
US20140005163A1 (en) 2014-01-02
SG176572A1 (en) 2012-01-30
CN102574845B (zh) 2015-09-02
IL216452A0 (en) 2012-01-31
EA020715B1 (ru) 2015-01-30
BRPI1010621A2 (pt) 2016-06-21
KR20120034710A (ko) 2012-04-12
CR20110608A (es) 2012-01-16
JP5596137B2 (ja) 2014-09-24
CO6470887A2 (es) 2012-06-29
ECSP11011500A (es) 2012-01-31
MX2011012943A (es) 2012-01-27
CN102574845A (zh) 2012-07-11
CA2763821A1 (en) 2010-12-09
DOP2011000373A (es) 2011-12-31
GEP20156267B (en) 2015-04-14
TW201102386A (en) 2011-01-16
EP2438064A1 (en) 2012-04-11
JP2012528828A (ja) 2012-11-15
EA201101704A1 (ru) 2012-07-30
AR076949A1 (es) 2011-07-20
TWI464168B (zh) 2014-12-11
US8476294B2 (en) 2013-07-02
NZ596487A (en) 2012-11-30
AU2010255727B2 (en) 2013-02-28
MA33332B1 (fr) 2012-06-01
WO2010139731A1 (en) 2010-12-09
NI201100209A (es) 2012-02-02
ZA201108439B (en) 2012-08-29
PE20120224A1 (es) 2012-04-04
UY32682A (es) 2011-01-31
CL2011003052A1 (es) 2012-08-31
TN2011000626A1 (en) 2013-05-24
KR101445458B1 (ko) 2014-10-07
CU24064B1 (es) 2014-12-26

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