EA200501891A1 - Гуманизированные антитела, распознающие бета-амилоидный пептид - Google Patents

Гуманизированные антитела, распознающие бета-амилоидный пептид

Info

Publication number
EA200501891A1
EA200501891A1 EA200501891A EA200501891A EA200501891A1 EA 200501891 A1 EA200501891 A1 EA 200501891A1 EA 200501891 A EA200501891 A EA 200501891A EA 200501891 A EA200501891 A EA 200501891A EA 200501891 A1 EA200501891 A1 EA 200501891A1
Authority
EA
Eurasian Patent Office
Prior art keywords
humanized antibodies
amyloid peptide
beta amyloid
recognizing beta
recognizing
Prior art date
Application number
EA200501891A
Other languages
English (en)
Other versions
EA012407B1 (ru
Inventor
Гарик Бэзи
Джоз В. Салданха
Фредерик Бард
Original Assignee
Ньюралаб Лимитед
Вайет
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ньюралаб Лимитед, Вайет filed Critical Ньюралаб Лимитед
Publication of EA200501891A1 publication Critical patent/EA200501891A1/ru
Publication of EA012407B1 publication Critical patent/EA012407B1/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77Internalization into the cell
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

Изобретение охватывает улучшенные агенты и способы лечения заболеваний, ассоциированных с амилоидными отложениями Аβ в мозгу пациента. Предпочтительные агенты включают антитела, например гуманизированные антитела.
EA200501891A 2003-05-30 2004-06-01 Гуманизированный иммуноглобулин, который специфически связывается с бета-амилоидным пептидом, и способы его применения EA012407B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47465403P 2003-05-30 2003-05-30
PCT/US2004/017514 WO2004108895A2 (en) 2003-05-30 2004-06-01 Humanized antibodies that recognize beta amyloid peptide

Publications (2)

Publication Number Publication Date
EA200501891A1 true EA200501891A1 (ru) 2006-06-30
EA012407B1 EA012407B1 (ru) 2009-10-30

Family

ID=33511618

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200501891A EA012407B1 (ru) 2003-05-30 2004-06-01 Гуманизированный иммуноглобулин, который специфически связывается с бета-амилоидным пептидом, и способы его применения

Country Status (31)

Country Link
US (1) US7871615B2 (ru)
EP (1) EP1636268B8 (ru)
JP (1) JP4908203B2 (ru)
KR (2) KR101455479B1 (ru)
CN (1) CN1798766B (ru)
AR (1) AR044580A1 (ru)
AT (1) ATE545656T1 (ru)
AU (1) AU2004245989B2 (ru)
BR (1) BRPI0410860A (ru)
CA (1) CA2525975C (ru)
CO (1) CO5660296A2 (ru)
CR (1) CR8095A (ru)
DK (1) DK1636268T3 (ru)
EA (1) EA012407B1 (ru)
EC (1) ECSP056263A (ru)
ES (1) ES2382547T3 (ru)
HK (1) HK1088617A1 (ru)
IL (1) IL171877A (ru)
MX (1) MXPA05012718A (ru)
MY (1) MY176959A (ru)
NO (1) NO20055415L (ru)
NZ (1) NZ544324A (ru)
PE (1) PE20050627A1 (ru)
PL (1) PL1636268T3 (ru)
PT (1) PT1636268E (ru)
SI (1) SI1636268T1 (ru)
TW (2) TWI374893B (ru)
UA (1) UA90846C2 (ru)
UY (1) UY28337A1 (ru)
WO (1) WO2004108895A2 (ru)
ZA (1) ZA200509585B (ru)

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