DE60043165D1 - Globularer Aufbau vom Amyloid-beta- protein und deren Verwendungen - Google Patents

Globularer Aufbau vom Amyloid-beta- protein und deren Verwendungen

Info

Publication number
DE60043165D1
DE60043165D1 DE60043165T DE60043165T DE60043165D1 DE 60043165 D1 DE60043165 D1 DE 60043165D1 DE 60043165 T DE60043165 T DE 60043165T DE 60043165 T DE60043165 T DE 60043165T DE 60043165 D1 DE60043165 D1 DE 60043165D1
Authority
DE
Germany
Prior art keywords
addls
activity
formation
amyloid beta
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60043165T
Other languages
English (en)
Inventor
Grant A Kraft
William L Klein
Brett A Chromy
Mary P Lambert
Caleb E Finch
Todd Morgan
Pat Wals
Irina Rozovsky
Ann Barlow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Northwestern University
University of Southern California USC
Original Assignee
Northwestern University
University of Southern California USC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23454671&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60043165(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Northwestern University, University of Southern California USC filed Critical Northwestern University
Application granted granted Critical
Publication of DE60043165D1 publication Critical patent/DE60043165D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE60043165T 1999-08-04 2000-08-04 Globularer Aufbau vom Amyloid-beta- protein und deren Verwendungen Expired - Lifetime DE60043165D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36923699A 1999-08-04 1999-08-04

Publications (1)

Publication Number Publication Date
DE60043165D1 true DE60043165D1 (de) 2009-11-26

Family

ID=23454671

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60016227T Expired - Lifetime DE60016227T2 (de) 1999-08-04 2000-08-04 Globularer aufbau vom amyloid-beta- protein und deren verwendungen
DE60043165T Expired - Lifetime DE60043165D1 (de) 1999-08-04 2000-08-04 Globularer Aufbau vom Amyloid-beta- protein und deren Verwendungen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60016227T Expired - Lifetime DE60016227T2 (de) 1999-08-04 2000-08-04 Globularer aufbau vom amyloid-beta- protein und deren verwendungen

Country Status (9)

Country Link
EP (2) EP1571158B1 (de)
JP (1) JP4796725B2 (de)
AT (2) ATE445639T1 (de)
AU (1) AU6524500A (de)
CA (1) CA2381323C (de)
DE (2) DE60016227T2 (de)
ES (1) ES2235926T3 (de)
HK (1) HK1047944A1 (de)
WO (1) WO2001010900A2 (de)

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TWI239847B (en) 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US20080050367A1 (en) 1998-04-07 2008-02-28 Guriq Basi Humanized antibodies that recognize beta amyloid peptide
US7964192B1 (en) 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
US7790856B2 (en) 1998-04-07 2010-09-07 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
CN101670105B (zh) 2000-02-24 2014-08-06 华盛顿大学 螯合淀粉样蛋白β肽的人源化抗体
EP1309341A2 (de) 2000-07-07 2003-05-14 Lars Lannfelt Prävention und behandlung der alzheimer krankheit
US7700751B2 (en) 2000-12-06 2010-04-20 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize β-amyloid peptide
DK1944040T3 (da) 2001-08-17 2012-10-29 Univ Washington Analysefremgangsmåde for Alzheimers sygdom
EP1288226A1 (de) * 2001-09-03 2003-03-05 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Modifizierung der Geneexpression der Mitglieder von "Toll"-ähnlicher Rezeptorfamilie zur Beeinflussung der Neurodegeneration und der Neuroprotektion im menschlichen Zentralnervensystem
MY139983A (en) 2002-03-12 2009-11-30 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
AU2003262553A1 (en) * 2002-07-31 2004-02-23 Solvias Ag Device and method for measurement
WO2004031400A2 (en) * 2002-10-01 2004-04-15 Northwestern University Amyloid beta-derived diffusible ligands (addls), addl-surrogates, addl-binding molecules, and uses thereof
DE10303974A1 (de) * 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
WO2004071408A2 (en) 2003-02-10 2004-08-26 Applied Molecular Evolution, Inc. Aβ BINDING MOLECULES
PE20050627A1 (es) 2003-05-30 2005-08-10 Wyeth Corp Anticuerpos humanizados que reconocen el peptido beta amiloideo
US8250823B2 (en) 2003-08-26 2012-08-28 Ejot Gmbh & Co. Kg Dowels and methods for the assembly of insulating panels
JP2008500286A (ja) * 2004-05-14 2008-01-10 ノースウエスタン ユニバーシティ Ａｄｄｌ受容体を含む組成物、関連する組成物、および関連する方法
SE0401601D0 (sv) 2004-06-21 2004-06-21 Bioarctic Neuroscience Ab Protofibril specific antibodies and uses thereof
WO2006066089A1 (en) 2004-12-15 2006-06-22 Neuralab Limited Humanized amyloid beta antibodies for use in improving cognition
KR20080021585A (ko) 2005-03-05 2008-03-07 애보트 게엠베하 운트 콤파니 카게 스크리닝 방법, 비확산성 ａ-베타 올리고머의 정제 방법,당해 비확산성 ａ-베타 올리고머에 대한 선택적 항체 및당해 항체의 제조 방법
DE102005014936A1 (de) 2005-03-24 2006-12-14 Abbott Gmbh & Co. Kg Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung
TW200726774A (en) * 2005-06-30 2007-07-16 Merck & Co Inc Composition and method for producing stable amyloid beta oligomers
CN101506236B (zh) 2005-11-30 2012-12-12 雅培制药有限公司 抗淀粉样β蛋白的单克隆抗体及其用途
BRPI0619249A2 (pt) 2005-11-30 2011-09-20 Abbott Lab anticorpos anti-globulÈmeros-aß, frações que se ligam a antìgeno destes, hibridomas correspondentes, ácidos nucléicos, vetores, células hospedeiras, métodos de produzir os ditos anticorpos, composições compreendendo os ditos anticorpos, usos dos ditos anticorpos e métodos de usar os ditos anticorpos
US8263558B2 (en) 2005-11-30 2012-09-11 Abbott Laboratories Methods of preparation of recombinant forms of human beta-amyloid protein and uses of these proteins
KR101413615B1 (ko) 2006-03-23 2014-07-18 바이오악틱 뉴로사이언스 에이비 인간 프로토피브릴에 선택적인 개선된 항체 및 이의 용도
US8784810B2 (en) 2006-04-18 2014-07-22 Janssen Alzheimer Immunotherapy Treatment of amyloidogenic diseases
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
LT2842967T (lt) 2007-01-18 2017-02-27 Eli Lilly And Company Beta amiloido pegilintas fab
EP2486928A1 (de) 2007-02-27 2012-08-15 Abbott GmbH & Co. KG Verfahren zur Behandlung von Amyloidosen
US8003097B2 (en) 2007-04-18 2011-08-23 Janssen Alzheimer Immunotherapy Treatment of cerebral amyloid angiopathy
PL2182983T3 (pl) 2007-07-27 2014-10-31 Janssen Alzheimer Immunotherap Leczenie chorób amyloidowych z wykorzystaniem humanizowanych przeciwciał specyficznych względem Abeta
JO3076B1 (ar) 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap نظم العلاج المناعي المعتمد على حالة apoe
CA2707309A1 (en) 2007-12-18 2009-06-25 Acumen Pharmaceuticals, Inc. Novel addl receptor polypeptides, polynucleotides and host cells for recombinant production
US9067981B1 (en) 2008-10-30 2015-06-30 Janssen Sciences Ireland Uc Hybrid amyloid-beta antibodies
US20120100129A1 (en) * 2009-06-29 2012-04-26 Gellerfors Paer N-Terminal Truncated Protofibrils/Oligomers for Use in Therapeutic and Diagnostic Methods for Alzheimer's Disease and Related Disorders
EP2368558A1 (de) 2010-03-23 2011-09-28 Mdc Max-Delbrück-Centrum Für Molekulare Medizin Berlin - Buch Azoverbindungen zur Reduzierung der Bildung und der Toxizität von Amyloid-Beta-Aggregationszwischenprodukten
MX360403B (es) 2010-04-15 2018-10-31 Abbvie Inc Proteinas de union a amiloide beta.
JP6147665B2 (ja) 2010-08-14 2017-06-14 アッヴィ・インコーポレイテッド アミロイドベータ結合タンパク質
WO2013009667A1 (en) 2011-07-13 2013-01-17 Merck Sharp & Dohme Corp. Method for detection of amyloid beta oligomers in a fluid sample and uses thereof
WO2013164763A2 (en) 2012-04-30 2013-11-07 Innovative Health Diagnostics A biological complex specific for alzheimer's disease detection in vitro and use thereof
EP3166970B1 (de) 2014-07-10 2021-03-10 BioArctic AB Verbesserte ass-protofibrilenbindende antikörper
WO2019018445A1 (en) * 2017-07-17 2019-01-24 Maxwell Biosciences, Inc. POLYTHERAPY MODULATING THE MODULATION OF CATHELICIDINE GENE EXPRESSION FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND OTHER DISEASES
WO2023107830A1 (en) * 2021-12-06 2023-06-15 The Board Of Trustees Of The Leland Stanford Junior University Amyloid oligomer compositions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5948763A (en) 1995-06-07 1999-09-07 New York University Peptides and pharmaceutical compositions thereof for treatment of disorders or diseases associated with abnormal protein folding into amyloid or amyloid-like deposits
US6218506B1 (en) 1997-02-05 2001-04-17 Northwestern University Amyloid β protein (globular assembly and uses thereof)
JP2001514661A (ja) * 1997-03-11 2001-09-11 ザ ジェネラル ホスピタル コーポレイション アルツハイマー病の処置における使用のための薬剤の同定

Also Published As

Publication number Publication date
ES2235926T3 (es) 2005-07-16
EP1571158B1 (de) 2009-10-14
WO2001010900A3 (en) 2001-08-30
DE60016227D1 (de) 2004-12-30
EP1571158A2 (de) 2005-09-07
ATE283285T1 (de) 2004-12-15
WO2001010900A2 (en) 2001-02-15
EP1571158A3 (de) 2007-03-14
DE60016227T2 (de) 2005-12-15
ATE445639T1 (de) 2009-10-15
EP1200470A2 (de) 2002-05-02
JP4796725B2 (ja) 2011-10-19
CA2381323C (en) 2009-10-06
CA2381323A1 (en) 2001-02-15
EP1200470B1 (de) 2004-11-24
JP2003510023A (ja) 2003-03-18
AU6524500A (en) 2001-03-05
HK1047944A1 (zh) 2003-03-14

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Legal Events

Date Code Title Description
8381 Inventor (new situation)

Inventor name: KRAFFT, GRANT A., GLENVIEW, IL 60025, US

Inventor name: KLEIN, WILLIAM L., WINNETKA, IL 60093, US

Inventor name: CHROMY, BRETT A., DANVILL, CA 94526, US

Inventor name: LAMBERT, MARY P., GLENVIEW, IL 60025, US

Inventor name: FINCH, CALEB E., ALTADENA, CA 91101, US

Inventor name: MORGAN, TODD, MANHATTAN BEACH, CA 90266, US

Inventor name: WALS, PAT, NEVADA CITY, CA 90059-9686, US

Inventor name: ROZOVSKY, IRINA, PASADENA, CA 91107, US

Inventor name: BARLOW, ANN, EVANSTON, IL 60201, US

8363 Opposition against the patent