WO1999031128A3 - Human tumor necrosis factor-r2-like proteins - Google Patents

Human tumor necrosis factor-r2-like proteins Download PDF

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Publication number
WO1999031128A3
WO1999031128A3 PCT/US1998/025649 US9825649W WO9931128A3 WO 1999031128 A3 WO1999031128 A3 WO 1999031128A3 US 9825649 W US9825649 W US 9825649W WO 9931128 A3 WO9931128 A3 WO 9931128A3
Authority
WO
WIPO (PCT)
Prior art keywords
proteins
necrosis factor
tumor necrosis
human tumor
tr2p
Prior art date
Application number
PCT/US1998/025649
Other languages
French (fr)
Other versions
WO1999031128A2 (en
Inventor
Olga Bandman
Jennifer L Hillman
Janice Au-Young
Y Tom Tang
Matthew R Kaser
Original Assignee
Incyte Pharma Inc
Olga Bandman
Jennifer L Hillman
Au Young Janice
Y Tom Tang
Matthew R Kaser
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Pharma Inc, Olga Bandman, Jennifer L Hillman, Au Young Janice, Y Tom Tang, Matthew R Kaser filed Critical Incyte Pharma Inc
Priority to JP2000539051A priority Critical patent/JP2002508168A/en
Priority to CA002314884A priority patent/CA2314884A1/en
Priority to EP98959662A priority patent/EP1037908A2/en
Priority to AU15416/99A priority patent/AU1541699A/en
Publication of WO1999031128A2 publication Critical patent/WO1999031128A2/en
Publication of WO1999031128A3 publication Critical patent/WO1999031128A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The invention provides human tumor necrosis factor-R2-like proteins (TR2P) and polynucleotides which identify and encode TR2P. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of TR2P.
PCT/US1998/025649 1997-12-16 1998-12-02 Human tumor necrosis factor-r2-like proteins WO1999031128A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2000539051A JP2002508168A (en) 1997-12-16 1998-12-02 Human tumor necrosis factor R2-like protein
CA002314884A CA2314884A1 (en) 1997-12-16 1998-12-02 Human tumor necrosis factor-r2-like proteins
EP98959662A EP1037908A2 (en) 1997-12-16 1998-12-02 Human tumor necrosis factor-r2-like proteins
AU15416/99A AU1541699A (en) 1997-12-16 1998-12-02 Human tumor necrosis factor-r2-like proteins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99194597A 1997-12-16 1997-12-16
US08/991,945 1997-12-16

Publications (2)

Publication Number Publication Date
WO1999031128A2 WO1999031128A2 (en) 1999-06-24
WO1999031128A3 true WO1999031128A3 (en) 1999-10-07

Family

ID=25537754

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/025649 WO1999031128A2 (en) 1997-12-16 1998-12-02 Human tumor necrosis factor-r2-like proteins

Country Status (5)

Country Link
EP (1) EP1037908A2 (en)
JP (1) JP2002508168A (en)
AU (1) AU1541699A (en)
CA (1) CA2314884A1 (en)
WO (1) WO1999031128A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7285267B2 (en) 1997-01-14 2007-10-23 Human Genome Sciences, Inc. Tumor necrosis factor receptors 6α & 6β
DE69837996T2 (en) 1997-01-14 2008-02-28 Human Genome Sciences, Inc. TUMOR NECROSE FACTOR RECEPTORS 6 ALPHA & 6 BETA
US6949358B1 (en) 1997-06-11 2005-09-27 Human Genome Sciences, Inc. Human tumor necrosis factor receptor TR9
US6358508B1 (en) 1997-06-11 2002-03-19 Human Genome Sciences, Inc. Antibodies to human tumor necrosis factor receptor TR9
WO1999014330A1 (en) 1997-09-18 1999-03-25 Genentech, Inc. DcR3 POLYPEPTIDE, A TNFR HOMOLOG
DE19809978A1 (en) * 1998-03-09 1999-09-16 Basf Ag New soluble member of tumor necrosis factor receptor family, useful for identification specific modulators and for treating disease e.g. tumors
GB9812607D0 (en) * 1998-06-12 1998-08-12 Zeneca Ltd Protein
US20040220103A1 (en) 1999-04-19 2004-11-04 Immunex Corporation Soluble tumor necrosis factor receptor treatment of medical disorders
EP1210435A1 (en) 1999-08-04 2002-06-05 Amgen Inc. Fhm, A NOVEL MEMBER OF THE TNF LIGAND SUPERGENE FAMILY
AU6517800A (en) 1999-08-04 2001-03-05 Amgen, Inc. Ntr3, a member of the tnf-receptor supergene family

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997023614A1 (en) * 1995-12-22 1997-07-03 Amgen Inc. Osteoprotegerin
WO1998030694A2 (en) * 1997-01-14 1998-07-16 Human Genome Sciences, Inc. TUMOR NECROSIS FACTOR RECEPTORS 6α AND 6$g(b)
EP0861850A1 (en) * 1997-02-04 1998-09-02 Smithkline Beecham Corporation Tumor necrosis related receptor, TR4
WO1999004001A1 (en) * 1997-07-21 1999-01-28 Zymogenetics, Inc. Tumor necrosis factor receptor ztnfr-5
WO1999007738A2 (en) * 1997-08-06 1999-02-18 Regeneron Pharmaceuticals, Inc. Human orphan receptor ntr-1
WO1999014330A1 (en) * 1997-09-18 1999-03-25 Genentech, Inc. DcR3 POLYPEPTIDE, A TNFR HOMOLOG

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997023614A1 (en) * 1995-12-22 1997-07-03 Amgen Inc. Osteoprotegerin
WO1998030694A2 (en) * 1997-01-14 1998-07-16 Human Genome Sciences, Inc. TUMOR NECROSIS FACTOR RECEPTORS 6α AND 6$g(b)
EP0861850A1 (en) * 1997-02-04 1998-09-02 Smithkline Beecham Corporation Tumor necrosis related receptor, TR4
WO1999004001A1 (en) * 1997-07-21 1999-01-28 Zymogenetics, Inc. Tumor necrosis factor receptor ztnfr-5
WO1999007738A2 (en) * 1997-08-06 1999-02-18 Regeneron Pharmaceuticals, Inc. Human orphan receptor ntr-1
WO1999014330A1 (en) * 1997-09-18 1999-03-25 Genentech, Inc. DcR3 POLYPEPTIDE, A TNFR HOMOLOG

Also Published As

Publication number Publication date
CA2314884A1 (en) 1999-06-24
AU1541699A (en) 1999-07-05
JP2002508168A (en) 2002-03-19
WO1999031128A2 (en) 1999-06-24
EP1037908A2 (en) 2000-09-27

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