BR0014281A - Vacina contra vìrus de gripe intranasal - Google Patents
Vacina contra vìrus de gripe intranasalInfo
- Publication number
- BR0014281A BR0014281A BR0014281-6A BR0014281A BR0014281A BR 0014281 A BR0014281 A BR 0014281A BR 0014281 A BR0014281 A BR 0014281A BR 0014281 A BR0014281 A BR 0014281A
- Authority
- BR
- Brazil
- Prior art keywords
- vaccine
- flu virus
- vaccine against
- intranasal
- dose
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Otolaryngology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
"VACINA CONTRA VìRUS DE GRIPE INTRANASAL". A invenção refere-se ao uso de uma preparação de antígeno de vírus da gripe não-vivo, particularmente uma preparação de vírus da gripe de rotura, na fabricação de uma formulação de vacina para uma vacinação intranasal de uma dose contra gripe, em que a vacinação de uma dose alcança exigências reguladoras internacionais para vacinas contra gripe. Além disso são fornecidos métodos para a produção da vacina, e um kit farmacêutico compreendendo um dispositivo de administração intranasal e a vacina de uma dose.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9922700.1A GB9922700D0 (en) | 1999-09-24 | 1999-09-24 | Vaccine |
GBGB9922703.5A GB9922703D0 (en) | 1999-09-24 | 1999-09-24 | Vaccine |
GB0016686A GB0016686D0 (en) | 2000-07-06 | 2000-07-06 | Novel vaccine |
PCT/EP2000/009367 WO2001021151A1 (en) | 1999-09-24 | 2000-09-22 | Intranasal influenza virus vaccine |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0014281A true BR0014281A (pt) | 2002-05-21 |
Family
ID=27255796
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0014281-6A BR0014281A (pt) | 1999-09-24 | 2000-09-22 | Vacina contra vìrus de gripe intranasal |
Country Status (23)
Country | Link |
---|---|
US (2) | US20050201946A1 (pt) |
EP (2) | EP1214054B1 (pt) |
JP (1) | JP4763197B2 (pt) |
KR (1) | KR20020038771A (pt) |
CN (1) | CN1391463A (pt) |
AR (2) | AR032597A1 (pt) |
AT (1) | ATE376825T1 (pt) |
AU (1) | AU764368B2 (pt) |
BR (1) | BR0014281A (pt) |
CA (1) | CA2383105C (pt) |
CO (1) | CO5280082A1 (pt) |
CZ (1) | CZ20021044A3 (pt) |
DE (1) | DE60036952T2 (pt) |
ES (1) | ES2293923T3 (pt) |
HU (1) | HUP0202846A3 (pt) |
IL (1) | IL148673A0 (pt) |
MX (1) | MXPA02003069A (pt) |
MY (1) | MY126588A (pt) |
NO (1) | NO20021431L (pt) |
NZ (1) | NZ517903A (pt) |
PL (1) | PL355287A1 (pt) |
TR (1) | TR200200776T2 (pt) |
WO (1) | WO2001021151A1 (pt) |
Families Citing this family (85)
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GB9923176D0 (en) * | 1999-09-30 | 1999-12-01 | Smithkline Beecham Biolog | Novel composition |
GB0024089D0 (en) * | 2000-10-02 | 2000-11-15 | Smithkline Beecham Biolog | Novel compounds |
PT1361890E (pt) | 2001-02-23 | 2011-06-07 | Glaxosmithkline Biolog Sa | Formulações vacinais de influenza para distribuição intradérmica |
MY134424A (en) * | 2001-05-30 | 2007-12-31 | Saechsisches Serumwerk | Stable influenza virus preparations with low or no amount of thiomersal |
JP5600375B2 (ja) | 2004-03-09 | 2014-10-01 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | インフルエンザウイルスワクチン |
EA014314B1 (ru) * | 2005-08-02 | 2010-10-29 | Новартис Вэксинес Энд Дайэгностикс Срл | Пониженная интерференция между маслосодержащими адъювантами и антигенами, содержащими поверхностно-активные вещества |
NZ567817A (en) | 2005-11-01 | 2012-01-12 | Novartis Vaccines & Diagnostic | Cell-derived viral vaccines with low levels of residual cell DNA by beta-propiolactone treatment |
US11707520B2 (en) | 2005-11-03 | 2023-07-25 | Seqirus UK Limited | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
EA014028B1 (ru) | 2005-11-04 | 2010-08-30 | Новартис Вэксинс Энд Диагностикс Срл | Эмульсии, содержащие свободное поверхностно-активное вещество в водной фазе в качестве адъюванта сплит вакцин против гриппа |
CA2628152C (en) | 2005-11-04 | 2016-02-02 | Novartis Vaccines And Diagnostics S.R.L. | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
US20110180430A1 (en) | 2005-11-04 | 2011-07-28 | Novartis Vaccines And Diagnostics Srl | Adjuvanted influenza vaccines including cytokine-inducing agents |
NZ568211A (en) | 2005-11-04 | 2011-11-25 | Novartis Vaccines & Diagnostic | Influenza vaccines including combinations of particulate adjuvants and immunopotentiators |
DK1976559T6 (da) | 2006-01-27 | 2020-04-06 | Seqirus Uk Ltd | Influenzavacciner indeholdende hæmagglutinin og matrixproteiner |
US20080038294A1 (en) * | 2006-03-22 | 2008-02-14 | Kersten Alexander J | Intranasal or inhalational administration of virosomes |
US8535683B2 (en) | 2006-03-22 | 2013-09-17 | Abbott Biologicals B.V. | Intranasal or inhalational administration of virosomes |
EP2004226A1 (en) | 2006-03-24 | 2008-12-24 | Novartis Vaccines and Diagnostics GmbH & Co. KG | Storage of influenza vaccines without refrigeration |
GB0614460D0 (en) | 2006-07-20 | 2006-08-30 | Novartis Ag | Vaccines |
CA2663196A1 (en) | 2006-09-11 | 2008-03-20 | Novartis Ag | Making influenza virus vaccines without using eggs |
CN101015691B (zh) * | 2006-11-14 | 2010-08-25 | 中国医学科学院医学生物学研究所 | 重组噬菌体流感疫苗 |
NZ577405A (en) | 2006-12-06 | 2012-08-31 | Novartis Ag | Vaccines including antigen from four strains of influenza virus |
EA201070066A1 (ru) | 2007-06-27 | 2010-06-30 | Новартис Аг | Вакцины против гриппа с низким содержанием добавок |
GB0810305D0 (en) | 2008-06-05 | 2008-07-09 | Novartis Ag | Influenza vaccination |
CA2710480A1 (en) | 2007-12-24 | 2009-07-02 | Novartis Ag | Assays for adsorbed influenza vaccines |
US8506966B2 (en) | 2008-02-22 | 2013-08-13 | Novartis Ag | Adjuvanted influenza vaccines for pediatric use |
EP2268309B1 (en) * | 2008-03-18 | 2015-01-21 | Novartis AG | Improvements in preparation of influenza virus vaccine antigens |
US20110070574A1 (en) * | 2008-06-02 | 2011-03-24 | Ge Healthcare Bio-Sciences Ab | Method for virus detection |
US20110217330A1 (en) | 2008-11-05 | 2011-09-08 | Bruno Rene Andre | Novel method |
CU20080215A7 (es) | 2008-11-19 | 2012-06-21 | Inst Finlay | Vacunas unitemporales |
DK2396032T3 (en) | 2009-02-10 | 2016-12-19 | Seqirus Uk Ltd | Influenza vaccines with reduced amounts of squalene |
JP2012517416A (ja) | 2009-02-10 | 2012-08-02 | ノバルティス アーゲー | 増加した量のh3抗原を含むインフルエンザワクチン |
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DE102010018462A1 (de) | 2009-04-27 | 2011-04-07 | Novartis Ag | Impfstoffe zum Schutz gegen Influenza |
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JP2022520443A (ja) * | 2019-02-15 | 2022-03-30 | セラム インスティチュート オブ インディア プライベイト リミテッド | 弱毒生インフルエンザワクチン組成物及びその調製プロセス |
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MY134424A (en) * | 2001-05-30 | 2007-12-31 | Saechsisches Serumwerk | Stable influenza virus preparations with low or no amount of thiomersal |
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2000
- 2000-09-22 PL PL00355287A patent/PL355287A1/xx not_active Application Discontinuation
- 2000-09-22 AT AT00967781T patent/ATE376825T1/de not_active IP Right Cessation
- 2000-09-22 MX MXPA02003069A patent/MXPA02003069A/es unknown
- 2000-09-22 AU AU77825/00A patent/AU764368B2/en not_active Ceased
- 2000-09-22 JP JP2001524577A patent/JP4763197B2/ja not_active Expired - Lifetime
- 2000-09-22 KR KR1020027003833A patent/KR20020038771A/ko not_active Application Discontinuation
- 2000-09-22 HU HU0202846A patent/HUP0202846A3/hu unknown
- 2000-09-22 ES ES00967781T patent/ES2293923T3/es not_active Expired - Lifetime
- 2000-09-22 CA CA2383105A patent/CA2383105C/en not_active Expired - Lifetime
- 2000-09-22 EP EP00967781A patent/EP1214054B1/en not_active Expired - Lifetime
- 2000-09-22 EP EP07119192A patent/EP1878424A3/en not_active Withdrawn
- 2000-09-22 TR TR2002/00776T patent/TR200200776T2/xx unknown
- 2000-09-22 IL IL14867300A patent/IL148673A0/xx unknown
- 2000-09-22 WO PCT/EP2000/009367 patent/WO2001021151A1/en active IP Right Grant
- 2000-09-22 AR ARP000104979A patent/AR032597A1/es unknown
- 2000-09-22 CO CO00072097A patent/CO5280082A1/es not_active Application Discontinuation
- 2000-09-22 AR ARP000104978A patent/AR025750A1/es unknown
- 2000-09-22 BR BR0014281-6A patent/BR0014281A/pt not_active Application Discontinuation
- 2000-09-22 MY MYPI20004435 patent/MY126588A/en unknown
- 2000-09-22 DE DE60036952T patent/DE60036952T2/de not_active Expired - Lifetime
- 2000-09-22 NZ NZ517903A patent/NZ517903A/en not_active IP Right Cessation
- 2000-09-22 CN CN00815945A patent/CN1391463A/zh active Pending
- 2000-09-22 CZ CZ20021044A patent/CZ20021044A3/cs unknown
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2002
- 2002-03-21 NO NO20021431A patent/NO20021431L/no not_active Application Discontinuation
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2005
- 2005-05-02 US US11/119,994 patent/US20050201946A1/en not_active Abandoned
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CA2383105A1 (en) | 2001-03-29 |
EP1878424A3 (en) | 2008-04-09 |
EP1214054B1 (en) | 2007-10-31 |
DE60036952T2 (de) | 2008-08-07 |
HUP0202846A2 (hu) | 2002-12-28 |
ATE376825T1 (de) | 2007-11-15 |
MXPA02003069A (es) | 2002-09-30 |
JP4763197B2 (ja) | 2011-08-31 |
AU764368B2 (en) | 2003-08-14 |
IL148673A0 (en) | 2002-09-12 |
EP1214054A1 (en) | 2002-06-19 |
AR032597A1 (es) | 2003-11-19 |
CA2383105C (en) | 2010-01-26 |
PL355287A1 (en) | 2004-04-05 |
CZ20021044A3 (cs) | 2002-08-14 |
ES2293923T3 (es) | 2008-04-01 |
HUP0202846A3 (en) | 2003-12-29 |
US20090155309A1 (en) | 2009-06-18 |
US20050201946A1 (en) | 2005-09-15 |
CN1391463A (zh) | 2003-01-15 |
NO20021431D0 (no) | 2002-03-21 |
MY126588A (en) | 2006-10-31 |
KR20020038771A (ko) | 2002-05-23 |
NO20021431L (no) | 2002-04-24 |
EP1878424A2 (en) | 2008-01-16 |
AU7782500A (en) | 2001-04-24 |
WO2001021151A1 (en) | 2001-03-29 |
TR200200776T2 (tr) | 2002-06-21 |
NZ517903A (en) | 2003-10-31 |
JP2003509451A (ja) | 2003-03-11 |
DE60036952D1 (de) | 2007-12-13 |
CO5280082A1 (es) | 2003-05-30 |
AR025750A1 (es) | 2002-12-11 |
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