BR0014281A - Vacina contra vìrus de gripe intranasal - Google Patents
Vacina contra vìrus de gripe intranasalInfo
- Publication number
- BR0014281A BR0014281A BR0014281-6A BR0014281A BR0014281A BR 0014281 A BR0014281 A BR 0014281A BR 0014281 A BR0014281 A BR 0014281A BR 0014281 A BR0014281 A BR 0014281A
- Authority
- BR
- Brazil
- Prior art keywords
- vaccine
- flu virus
- vaccine against
- intranasal
- dose
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Abstract
"VACINA CONTRA VìRUS DE GRIPE INTRANASAL". A invenção refere-se ao uso de uma preparação de antígeno de vírus da gripe não-vivo, particularmente uma preparação de vírus da gripe de rotura, na fabricação de uma formulação de vacina para uma vacinação intranasal de uma dose contra gripe, em que a vacinação de uma dose alcança exigências reguladoras internacionais para vacinas contra gripe. Além disso são fornecidos métodos para a produção da vacina, e um kit farmacêutico compreendendo um dispositivo de administração intranasal e a vacina de uma dose.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9922700.1A GB9922700D0 (en) | 1999-09-24 | 1999-09-24 | Vaccine |
GBGB9922703.5A GB9922703D0 (en) | 1999-09-24 | 1999-09-24 | Vaccine |
GB0016686A GB0016686D0 (en) | 2000-07-06 | 2000-07-06 | Novel vaccine |
PCT/EP2000/009367 WO2001021151A1 (en) | 1999-09-24 | 2000-09-22 | Intranasal influenza virus vaccine |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0014281A true BR0014281A (pt) | 2002-05-21 |
Family
ID=27255796
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0014281-6A BR0014281A (pt) | 1999-09-24 | 2000-09-22 | Vacina contra vìrus de gripe intranasal |
Country Status (23)
Country | Link |
---|---|
US (2) | US20050201946A1 (pt) |
EP (2) | EP1214054B1 (pt) |
JP (1) | JP4763197B2 (pt) |
KR (1) | KR20020038771A (pt) |
CN (1) | CN1391463A (pt) |
AR (2) | AR025750A1 (pt) |
AT (1) | ATE376825T1 (pt) |
AU (1) | AU764368B2 (pt) |
BR (1) | BR0014281A (pt) |
CA (1) | CA2383105C (pt) |
CO (1) | CO5280082A1 (pt) |
CZ (1) | CZ20021044A3 (pt) |
DE (1) | DE60036952T2 (pt) |
ES (1) | ES2293923T3 (pt) |
HU (1) | HUP0202846A3 (pt) |
IL (1) | IL148673A0 (pt) |
MX (1) | MXPA02003069A (pt) |
MY (1) | MY126588A (pt) |
NO (1) | NO20021431L (pt) |
NZ (1) | NZ517903A (pt) |
PL (1) | PL355287A1 (pt) |
TR (1) | TR200200776T2 (pt) |
WO (1) | WO2001021151A1 (pt) |
Families Citing this family (85)
Publication number | Priority date | Publication date | Assignee | Title |
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GB9923176D0 (en) * | 1999-09-30 | 1999-12-01 | Smithkline Beecham Biolog | Novel composition |
GB0024089D0 (en) * | 2000-10-02 | 2000-11-15 | Smithkline Beecham Biolog | Novel compounds |
DE60239594D1 (de) | 2001-02-23 | 2011-05-12 | Glaxosmithkline Biolog Sa | Influenza vakzinzusammensetzungen zur intradermaler verabreichung |
TWI228420B (en) * | 2001-05-30 | 2005-03-01 | Smithkline Beecham Pharma Gmbh | Novel vaccine composition |
EP1722815A1 (en) | 2004-03-09 | 2006-11-22 | Chiron Corporation | Influenza virus vaccines |
EA014314B1 (ru) * | 2005-08-02 | 2010-10-29 | Новартис Вэксинес Энд Дайэгностикс Срл | Пониженная интерференция между маслосодержащими адъювантами и антигенами, содержащими поверхностно-активные вещества |
ES2359214T5 (es) | 2005-11-01 | 2014-10-08 | Novartis Vaccines And Diagnostics Gmbh | Vacunas virales derivadas de células con niveles reducidos de ADN celular residual por tratamiento con beta-propiolactona |
US11707520B2 (en) | 2005-11-03 | 2023-07-25 | Seqirus UK Limited | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
JP2009514839A (ja) | 2005-11-04 | 2009-04-09 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル | サイトカイン誘導剤を含むアジュバントインフルエンザワクチン |
BRPI0618254A2 (pt) | 2005-11-04 | 2011-08-23 | Novartis Vaccines & Diagnostic | emulsões com agente tensoativo de fase aquosa livre para fornecer adjuvante às vacinas contra influenza dividido |
PT1951299E (pt) | 2005-11-04 | 2012-02-28 | Novartis Vaccines & Diagnostic | Vacinas contra a gripe que incluem combinações de adjuvantes particulados e imuno-potenciadores |
EP1945252B1 (en) | 2005-11-04 | 2013-05-29 | Novartis Vaccines and Diagnostics S.r.l. | Vaccines comprising purified surface antigens prepared from influenza viruses grown in cell culture, adjuvanted with squalene |
JP6087041B2 (ja) | 2006-01-27 | 2017-03-08 | ノバルティス アーゲー | 血球凝集素およびマトリックスタンパク質を含むインフルエンザウイルスワクチン |
US8535683B2 (en) | 2006-03-22 | 2013-09-17 | Abbott Biologicals B.V. | Intranasal or inhalational administration of virosomes |
US20080038294A1 (en) * | 2006-03-22 | 2008-02-14 | Kersten Alexander J | Intranasal or inhalational administration of virosomes |
WO2007110776A1 (en) | 2006-03-24 | 2007-10-04 | Novartis Vaccines And Diagnostics Gmbh & Co Kg | Storage of influenza vaccines without refrigeration |
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ES2536401T3 (es) | 2006-09-11 | 2015-05-25 | Novartis Ag | Fabricación de vacunas contra virus de la gripe sin usar huevos |
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US8506966B2 (en) | 2008-02-22 | 2013-08-13 | Novartis Ag | Adjuvanted influenza vaccines for pediatric use |
JP5518041B2 (ja) | 2008-03-18 | 2014-06-11 | ノバルティス アーゲー | インフルエンザウイルスワクチン抗原の調製における改良 |
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US20110217330A1 (en) | 2008-11-05 | 2011-09-08 | Bruno Rene Andre | Novel method |
CU20080215A7 (es) | 2008-11-19 | 2012-06-21 | Inst Finlay | Vacunas unitemporales |
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JP7237344B2 (ja) | 2016-06-15 | 2023-03-13 | アイカーン スクール オブ メディシン アット マウント サイナイ | インフルエンザウイルス血球凝集素タンパク質及びその使用 |
CA3058652A1 (en) | 2017-04-07 | 2018-10-11 | Icahn School Of Medicine At Mount Sinai | Anti-influenza b virus neuraminidase antibodies and uses thereof |
WO2020165912A1 (en) * | 2019-02-15 | 2020-08-20 | Serum Institute Of India Pvt Ltd. | Live attenuated influenza vaccine composition and process for preparation thereof |
BR112021016778A2 (pt) | 2019-02-25 | 2021-11-16 | Seqirus Uk Ltd | Vacinas contra influenza multivalentes com adjuvante e usos |
WO2021090067A2 (en) | 2019-11-07 | 2021-05-14 | Seqirus UK Limited | Compositions and methods for producing a viral vaccine with reduced particle size |
WO2021099419A1 (en) | 2019-11-18 | 2021-05-27 | Seqirus UK Limited | Method for producing reassortant influenza viruses |
CN113599513A (zh) * | 2020-10-23 | 2021-11-05 | 青岛大学 | 一种适用于咽喉部接种的新型冠状病毒疫苗的制备方法及接种方法 |
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SE8205892D0 (sv) * | 1982-10-18 | 1982-10-18 | Bror Morein | Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin |
CA1291036C (en) * | 1986-04-23 | 1991-10-22 | Edwin I. Stoltz | Nasal administration of drugs |
NZ230747A (en) * | 1988-09-30 | 1992-05-26 | Bror Morein | Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina |
DK17093D0 (da) * | 1993-02-15 | 1993-02-15 | Lyfjathroun H F | Farmaceutisk praeparat til topisk administrering af antigener og/eller vacciner til pattedyr via slimhinder |
CN1124013A (zh) * | 1993-02-19 | 1996-06-05 | 史密丝克莱恩比彻姆公司 | 含3-邻位-脱酰基的单磷酰基脂质a的流感疫苗组合物 |
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US5653987A (en) * | 1995-05-16 | 1997-08-05 | Modi; Pankaj | Liquid formulations for proteinic pharmaceuticals |
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WO1999052549A1 (en) * | 1998-04-09 | 1999-10-21 | Smithkline Beecham Biologicals S.A. | Adjuvant compositions |
AT407958B (de) * | 1999-02-11 | 2001-07-25 | Immuno Ag | Inaktivierte influenza-virus-vakzine zur nasalen oder oralen applikation |
US6506803B1 (en) * | 1999-04-28 | 2003-01-14 | Regents Of The University Of Michigan | Methods of preventing and treating microbial infections |
AU2001276831A1 (en) * | 2000-06-22 | 2002-01-02 | Rxkinetix, Inc. | Delivery vehicle composition and methods for delivering antigens and other drugs |
AR032575A1 (es) * | 2001-02-23 | 2003-11-12 | Smithkline Beecham Biolog | Uso de una preparacion antigenica de gripe para la fabricacion de una vacuna intradermica de la gripe y estuche farmaceutico que comprende dicha vacuna |
DE60239594D1 (de) * | 2001-02-23 | 2011-05-12 | Glaxosmithkline Biolog Sa | Influenza vakzinzusammensetzungen zur intradermaler verabreichung |
TWI228420B (en) * | 2001-05-30 | 2005-03-01 | Smithkline Beecham Pharma Gmbh | Novel vaccine composition |
US20090028903A1 (en) * | 2005-03-23 | 2009-01-29 | Glaxosmithkline Biologicals, S.A. | Novel use |
-
2000
- 2000-09-22 IL IL14867300A patent/IL148673A0/xx unknown
- 2000-09-22 MX MXPA02003069A patent/MXPA02003069A/es unknown
- 2000-09-22 DE DE60036952T patent/DE60036952T2/de not_active Expired - Lifetime
- 2000-09-22 AR ARP000104978A patent/AR025750A1/es unknown
- 2000-09-22 BR BR0014281-6A patent/BR0014281A/pt not_active Application Discontinuation
- 2000-09-22 JP JP2001524577A patent/JP4763197B2/ja not_active Expired - Lifetime
- 2000-09-22 EP EP00967781A patent/EP1214054B1/en not_active Expired - Lifetime
- 2000-09-22 PL PL00355287A patent/PL355287A1/xx not_active Application Discontinuation
- 2000-09-22 KR KR1020027003833A patent/KR20020038771A/ko not_active Application Discontinuation
- 2000-09-22 CA CA2383105A patent/CA2383105C/en not_active Expired - Lifetime
- 2000-09-22 MY MYPI20004435 patent/MY126588A/en unknown
- 2000-09-22 CN CN00815945A patent/CN1391463A/zh active Pending
- 2000-09-22 AR ARP000104979A patent/AR032597A1/es unknown
- 2000-09-22 CZ CZ20021044A patent/CZ20021044A3/cs unknown
- 2000-09-22 EP EP07119192A patent/EP1878424A3/en not_active Withdrawn
- 2000-09-22 HU HU0202846A patent/HUP0202846A3/hu unknown
- 2000-09-22 ES ES00967781T patent/ES2293923T3/es not_active Expired - Lifetime
- 2000-09-22 AU AU77825/00A patent/AU764368B2/en not_active Ceased
- 2000-09-22 CO CO00072097A patent/CO5280082A1/es not_active Application Discontinuation
- 2000-09-22 NZ NZ517903A patent/NZ517903A/en not_active IP Right Cessation
- 2000-09-22 WO PCT/EP2000/009367 patent/WO2001021151A1/en active IP Right Grant
- 2000-09-22 TR TR2002/00776T patent/TR200200776T2/xx unknown
- 2000-09-22 AT AT00967781T patent/ATE376825T1/de not_active IP Right Cessation
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2002
- 2002-03-21 NO NO20021431A patent/NO20021431L/no not_active Application Discontinuation
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2005
- 2005-05-02 US US11/119,994 patent/US20050201946A1/en not_active Abandoned
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2009
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NZ517903A (en) | 2003-10-31 |
EP1214054B1 (en) | 2007-10-31 |
NO20021431D0 (no) | 2002-03-21 |
PL355287A1 (en) | 2004-04-05 |
JP4763197B2 (ja) | 2011-08-31 |
US20050201946A1 (en) | 2005-09-15 |
ES2293923T3 (es) | 2008-04-01 |
DE60036952T2 (de) | 2008-08-07 |
AU764368B2 (en) | 2003-08-14 |
US20090155309A1 (en) | 2009-06-18 |
DE60036952D1 (de) | 2007-12-13 |
AR025750A1 (es) | 2002-12-11 |
TR200200776T2 (tr) | 2002-06-21 |
MXPA02003069A (es) | 2002-09-30 |
EP1214054A1 (en) | 2002-06-19 |
CA2383105C (en) | 2010-01-26 |
WO2001021151A1 (en) | 2001-03-29 |
CZ20021044A3 (cs) | 2002-08-14 |
EP1878424A3 (en) | 2008-04-09 |
AR032597A1 (es) | 2003-11-19 |
JP2003509451A (ja) | 2003-03-11 |
MY126588A (en) | 2006-10-31 |
NO20021431L (no) | 2002-04-24 |
HUP0202846A2 (hu) | 2002-12-28 |
CO5280082A1 (es) | 2003-05-30 |
CA2383105A1 (en) | 2001-03-29 |
EP1878424A2 (en) | 2008-01-16 |
AU7782500A (en) | 2001-04-24 |
KR20020038771A (ko) | 2002-05-23 |
CN1391463A (zh) | 2003-01-15 |
IL148673A0 (en) | 2002-09-12 |
ATE376825T1 (de) | 2007-11-15 |
HUP0202846A3 (en) | 2003-12-29 |
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