PT1361890E - Formulações vacinais de influenza para distribuição intradérmica - Google Patents
Formulações vacinais de influenza para distribuição intradérmica Download PDFInfo
- Publication number
- PT1361890E PT1361890E PT02724176T PT02724176T PT1361890E PT 1361890 E PT1361890 E PT 1361890E PT 02724176 T PT02724176 T PT 02724176T PT 02724176 T PT02724176 T PT 02724176T PT 1361890 E PT1361890 E PT 1361890E
- Authority
- PT
- Portugal
- Prior art keywords
- intradermal delivery
- influenza vaccine
- vaccine formulations
- influenza
- intradermal
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Pulmonology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Surgical Instruments (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0104538A GB0104538D0 (en) | 2001-02-23 | 2001-02-23 | Novel Vaccine |
GB0107511A GB0107511D0 (en) | 2001-03-26 | 2001-03-26 | Novel vaccine |
GB0108365A GB0108365D0 (en) | 2001-04-03 | 2001-04-03 | Novel compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1361890E true PT1361890E (pt) | 2011-06-07 |
Family
ID=27256080
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT02724176T PT1361890E (pt) | 2001-02-23 | 2002-02-21 | Formulações vacinais de influenza para distribuição intradérmica |
Country Status (11)
Country | Link |
---|---|
US (4) | US20040071734A1 (pt) |
EP (3) | EP2281573A3 (pt) |
JP (5) | JP5208347B2 (pt) |
AT (1) | ATE503493T1 (pt) |
AU (1) | AU2002254901A1 (pt) |
CA (1) | CA2438942A1 (pt) |
CY (1) | CY1111553T1 (pt) |
DE (3) | DE60239594D1 (pt) |
DK (1) | DK1361890T3 (pt) |
PT (1) | PT1361890E (pt) |
WO (1) | WO2002074336A2 (pt) |
Families Citing this family (81)
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BR0014281A (pt) * | 1999-09-24 | 2002-05-21 | Smithkline Beecham Biolog | Vacina contra vìrus de gripe intranasal |
DE60239594D1 (de) * | 2001-02-23 | 2011-05-12 | Glaxosmithkline Biolog Sa | Influenza vakzinzusammensetzungen zur intradermaler verabreichung |
AR032575A1 (es) * | 2001-02-23 | 2003-11-12 | Smithkline Beecham Biolog | Uso de una preparacion antigenica de gripe para la fabricacion de una vacuna intradermica de la gripe y estuche farmaceutico que comprende dicha vacuna |
GB2386072A (en) * | 2001-04-27 | 2003-09-10 | Becton Dickinson Co | Novel vaccine |
BR0210628A (pt) * | 2001-06-29 | 2004-08-10 | Becton Dickinson Co | Liberação intradérmica de vacinas e agentes terapêuticos genéticos via microcânula |
KR101251902B1 (ko) | 2003-02-25 | 2013-04-08 | 메디뮨 엘엘씨 | 인플루엔자 백신 조성물의 제조 방법 |
US20060110406A1 (en) | 2003-02-25 | 2006-05-25 | Medimmune Vaccines, Inc. | Refrigerator-temperature stable influenza vaccine compositions |
US20050123550A1 (en) * | 2003-05-12 | 2005-06-09 | Laurent Philippe E. | Molecules enhancing dermal delivery of influenza vaccines |
US7588774B2 (en) | 2003-05-12 | 2009-09-15 | Becton, Dickinson And Company | Molecules enhancing dermal delivery of influenza vaccines |
CA2529647C (en) | 2003-06-16 | 2013-08-13 | Medimmune Vaccines, Inc. | Influenza hemagglutinin and neuraminidase variants |
DE202005022108U1 (de) | 2004-03-09 | 2013-11-12 | Novartis Vaccines And Diagnostics, Inc. | Influenza-Virus-Impfstoffe |
WO2006041819A1 (en) * | 2004-10-06 | 2006-04-20 | Medimmune Vaccines, Inc. | Refrigerator-temperature stable influenza vaccine compositions |
CA2586690A1 (en) * | 2004-11-03 | 2006-06-15 | Novartis Vaccines And Diagnostics, Inc. | Influenza vaccination |
EP2441471B1 (en) | 2005-03-08 | 2014-10-08 | MedImmune, LLC | Reassortant influenza viruses |
HUE027837T2 (en) * | 2005-03-23 | 2016-11-28 | Glaxosmithkline Biologicals Sa | Adjuvant use of influenza virus and oil-in-water emulsion to induce CD4 T-cell and / or enhanced B-cell cellular response |
JP4828189B2 (ja) * | 2005-09-14 | 2011-11-30 | 雅美 森山 | 分泌型IgA及びIgG抗体誘導剤 |
AU2006310171B2 (en) | 2005-11-01 | 2011-02-17 | Seqirus UK Limited | Cell-derived viral vaccines with low levels of residual cell DNA by beta-propiolactone treatment |
CA2628152C (en) | 2005-11-04 | 2016-02-02 | Novartis Vaccines And Diagnostics S.R.L. | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
NZ567978A (en) | 2005-11-04 | 2011-09-30 | Novartis Vaccines & Diagnostic | Influenza vaccine with reduced amount of oil-in-water emulsion as adjuvant |
CA2628158C (en) | 2005-11-04 | 2015-12-15 | Novartis Vaccines And Diagnostics S.R.L. | Emulsions with free aqueous-phase surfactant as adjuvants for split influenza vaccines |
AU2006310337B9 (en) | 2005-11-04 | 2013-11-28 | Novartis Ag | Adjuvanted influenza vaccines including cytokine-inducing agents |
EP1951299B1 (en) | 2005-11-04 | 2012-01-04 | Novartis Vaccines and Diagnostics S.r.l. | Influenza vaccines including combinations of particulate adjuvants and immunopotentiators |
PL1976559T6 (pl) | 2006-01-27 | 2020-08-10 | Novartis Influenza Vaccines Marburg Gmbh | Szczepionki przeciw grypie zawierające hemaglutyninę i białka macierzy |
JP2009534303A (ja) * | 2006-03-24 | 2009-09-24 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス ゲーエムベーハー アンド カンパニー カーゲー | 冷蔵しないインフルエンザワクチンの保存 |
MX2009000660A (es) | 2006-07-17 | 2009-04-08 | Glaxosmithkline Biolog Sa | Vacuna de influenza. |
GB0614460D0 (en) | 2006-07-20 | 2006-08-30 | Novartis Ag | Vaccines |
CA2663196A1 (en) | 2006-09-11 | 2008-03-20 | Novartis Ag | Making influenza virus vaccines without using eggs |
US20080124355A1 (en) | 2006-09-22 | 2008-05-29 | David Gordon Bermudes | Live bacterial vaccines for viral infection prophylaxis or treatment |
JP2011506264A (ja) | 2006-12-06 | 2011-03-03 | ノバルティス アーゲー | インフルエンザウイルスの4つの株に由来する抗原を含むワクチン |
TW200908994A (en) | 2007-04-20 | 2009-03-01 | Glaxosmithkline Biolog Sa | Vaccine |
PL2175881T3 (pl) * | 2007-06-14 | 2012-12-31 | Crucell Switzerland Ag | Śródskórna szczepionka przeciwko grypie |
SI2185191T1 (sl) | 2007-06-27 | 2012-12-31 | Novartis Ag | Cepiva proti influenci z majhnimi dodatki |
GB0810305D0 (en) | 2008-06-05 | 2008-07-09 | Novartis Ag | Influenza vaccination |
AU2008339631B2 (en) | 2007-12-24 | 2014-07-24 | Novartis Ag | Assays for adsorbed influenza vaccines |
US8506966B2 (en) | 2008-02-22 | 2013-08-13 | Novartis Ag | Adjuvanted influenza vaccines for pediatric use |
EP2268309B1 (en) | 2008-03-18 | 2015-01-21 | Novartis AG | Improvements in preparation of influenza virus vaccine antigens |
EP2318043A4 (en) * | 2008-07-11 | 2012-01-25 | Medimmune Llc | INFLUENZA HEMAGGLUTININE AND NEURAMINIDASE VARIANTS |
JP5182753B2 (ja) * | 2008-09-01 | 2013-04-17 | 富士フイルム株式会社 | インフルエンザ罹患リスクの予測方法 |
JP2012507272A (ja) | 2008-11-05 | 2012-03-29 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 新規な方法 |
CN102438651A (zh) | 2009-02-10 | 2012-05-02 | 诺华有限公司 | 用于大流行相关毒株的流感疫苗方案 |
AU2010212550B2 (en) | 2009-02-10 | 2016-03-10 | Seqirus UK Limited | Influenza vaccines with reduced amounts of squalene |
CA2752041A1 (en) | 2009-02-10 | 2010-08-19 | Novartis Ag | Influenza vaccines with increased amounts of h3 antigen |
EP2424565A1 (en) | 2009-04-27 | 2012-03-07 | Novartis AG | Adjuvanted vaccines for protecting against influenza |
NZ596432A (en) | 2009-05-21 | 2013-05-31 | Novartis Ag | Reverse genetics using non-endogenous pol i promoters |
EP2459722B1 (en) | 2009-07-31 | 2017-09-06 | Seqirus UK Limited | Reverse genetics systems |
US20120237536A1 (en) | 2009-09-10 | 2012-09-20 | Novartis | Combination vaccines against respiratory tract diseases |
PL2491117T3 (pl) | 2009-10-20 | 2014-05-30 | Novartis Ag | Udoskonalone sposoby odzyskiwania wirusa wykorzystujące odwrotną genetykę |
GB0918830D0 (en) * | 2009-10-27 | 2009-12-09 | Glaxosmithkline Biolog Niederl | Process |
US9426989B2 (en) | 2010-05-06 | 2016-08-30 | Novartis Ag | Organic peroxide compounds for microorganism inactivation |
AU2011254204B2 (en) | 2010-05-21 | 2015-08-20 | Seqirus UK Limited | Influenza virus reassortment method |
BR112012030616A2 (pt) | 2010-06-01 | 2017-03-01 | Novartis Ag | concentração de antígenos de vacina com liofilização. |
PL2575872T3 (pl) | 2010-06-01 | 2021-02-22 | Seqirus UK Limited | Zatężanie antygenów szczepionkowych grypy bez liofilizacji |
WO2011154976A2 (en) | 2010-06-08 | 2011-12-15 | Panacea Biotec Limited | Improved influenza vaccine |
WO2012023044A1 (en) | 2010-08-20 | 2012-02-23 | Novartis Ag | Soluble needle arrays for delivery of influenza vaccines |
GB201216121D0 (en) | 2012-09-10 | 2012-10-24 | Novartis Ag | Sample quantification by disc centrifugation |
US20140248320A1 (en) | 2011-10-20 | 2014-09-04 | Novartis Ag | Adjuvanted influenza b virus vaccines for pediatric priming |
GB201120000D0 (en) * | 2011-11-20 | 2012-01-04 | Glaxosmithkline Biolog Sa | Vaccine |
CN103608453B (zh) | 2012-03-02 | 2018-07-24 | 思齐乐 | 流感病毒重配 |
CN104159608A (zh) | 2012-03-06 | 2014-11-19 | 克鲁塞尔荷兰公司 | 针对流感的改善的疫苗接种 |
AU2013270793A1 (en) | 2012-06-04 | 2014-12-11 | Novartis Ag | Improved safety testing |
GB201218195D0 (en) | 2012-10-10 | 2012-11-21 | Istituto Zooprofilattico Sperimentale Delle Venezie | Composition |
AU2013354219A1 (en) | 2012-12-03 | 2015-07-02 | Novartis Ag | Reassortant influenza a viren |
UY34506A (es) * | 2012-12-10 | 2014-06-30 | Fernando Amaury Ferreira Chiesa | Adyuvante de vacunación, preparación y vacunas que lo contienen |
MX2015008847A (es) | 2013-01-10 | 2015-10-30 | Novartis Ag | Composiciones inmunogenicas de virus de influenza y usos de las mismas. |
AU2014229255B2 (en) | 2013-03-13 | 2018-12-13 | Novartis Ag | Influenza B virus reassortment |
US20140335116A1 (en) | 2013-05-10 | 2014-11-13 | Novartis Ag | Avoiding narcolepsy risk in influenza vaccines |
DE202013005100U1 (de) | 2013-06-05 | 2013-08-26 | Novartis Ag | Influenza Virus Reassortierung |
DE202013005130U1 (de) | 2013-06-05 | 2013-09-10 | Novartis Ag | Influenza Virus Reassortierung |
CN105722976A (zh) | 2013-06-06 | 2016-06-29 | 诺华股份有限公司 | 流感病毒重配 |
JP6373376B2 (ja) | 2013-11-15 | 2018-08-15 | ノバルティス アーゲー | 残留細胞培養不純物の除去 |
EP3169324B1 (en) | 2014-07-14 | 2019-05-08 | Orion Biotechnology Canada Ltd. | Microbicidal composition comprising an octoxynol and a quinolizidine alkaloid compound or a source thereof |
US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
JP6719388B2 (ja) * | 2014-12-25 | 2020-07-08 | テルモ株式会社 | 皮内投与インフルエンザワクチン組成物 |
KR20180035807A (ko) | 2015-06-26 | 2018-04-06 | 세퀴러스 유케이 리미티드 | 항원적으로 매치된 인플루엔자 백신 |
HUE051783T2 (hu) | 2015-07-07 | 2021-03-29 | Seqirus Uk Ltd | Eljárás immunogén hemagglutinin mennyiségi meghatározására |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
MX2021010194A (es) | 2019-02-25 | 2022-01-24 | Seqirus Uk Ltd | Vacunas contra la influenza multivalentes adyuvantadas. |
US11471497B1 (en) | 2019-03-13 | 2022-10-18 | David Gordon Bermudes | Copper chelation therapeutics |
US20230220356A1 (en) | 2019-11-07 | 2023-07-13 | Seqirus UK Limited | Compositions and methods for producing a viral vaccine with reduced particle size |
WO2021099419A1 (en) | 2019-11-18 | 2021-05-27 | Seqirus UK Limited | Method for producing reassortant influenza viruses |
US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
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-
2002
- 2002-02-21 DE DE60239594T patent/DE60239594D1/de not_active Expired - Lifetime
- 2002-02-21 WO PCT/EP2002/001844 patent/WO2002074336A2/en active Application Filing
- 2002-02-21 JP JP2002573043A patent/JP5208347B2/ja not_active Expired - Fee Related
- 2002-02-21 EP EP20100178427 patent/EP2281573A3/en not_active Withdrawn
- 2002-02-21 PT PT02724176T patent/PT1361890E/pt unknown
- 2002-02-21 DK DK02724176.9T patent/DK1361890T3/da active
- 2002-02-21 AT AT02724176T patent/ATE503493T1/de active
- 2002-02-21 US US10/469,191 patent/US20040071734A1/en not_active Abandoned
- 2002-02-21 CA CA002438942A patent/CA2438942A1/en not_active Abandoned
- 2002-02-21 AU AU2002254901A patent/AU2002254901A1/en not_active Abandoned
- 2002-02-21 EP EP02724176A patent/EP1361890B1/en not_active Revoked
- 2002-02-21 EP EP10178402.3A patent/EP2269639B1/en not_active Expired - Lifetime
-
2007
- 2007-06-13 US US11/762,488 patent/US8557251B2/en not_active Expired - Fee Related
-
2009
- 2009-03-17 JP JP2009063830A patent/JP5960380B2/ja not_active Expired - Fee Related
-
2011
- 2011-06-08 CY CY20111100550T patent/CY1111553T1/el unknown
- 2011-09-15 JP JP2011201447A patent/JP6076592B2/ja not_active Expired - Fee Related
- 2011-09-29 DE DE201112100053 patent/DE122011100053I1/de active Pending
- 2011-09-29 DE DE201112100054 patent/DE122011100054I1/de active Pending
- 2011-10-12 US US13/271,839 patent/US9138471B2/en not_active Expired - Fee Related
- 2011-10-12 US US13/271,810 patent/US20120029437A1/en not_active Abandoned
-
2015
- 2015-04-16 JP JP2015084294A patent/JP6211555B2/ja not_active Expired - Fee Related
-
2017
- 2017-07-10 JP JP2017134258A patent/JP2017186367A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
DE122011100054I1 (de) | 2012-03-15 |
CY1111553T1 (el) | 2015-08-05 |
DK1361890T3 (da) | 2011-06-27 |
US20120039933A1 (en) | 2012-02-16 |
DE122011100053I1 (de) | 2012-03-15 |
US20040071734A1 (en) | 2004-04-15 |
EP2281573A3 (en) | 2011-12-07 |
US9138471B2 (en) | 2015-09-22 |
CA2438942A1 (en) | 2002-09-26 |
JP5960380B2 (ja) | 2016-08-02 |
AU2002254901A1 (en) | 2002-10-03 |
US8557251B2 (en) | 2013-10-15 |
US20120029437A1 (en) | 2012-02-02 |
WO2002074336A2 (en) | 2002-09-26 |
JP2009173664A (ja) | 2009-08-06 |
DE60239594D1 (de) | 2011-05-12 |
JP2015134819A (ja) | 2015-07-27 |
EP2269639B1 (en) | 2018-11-28 |
WO2002074336A3 (en) | 2003-08-14 |
EP2269639A3 (en) | 2011-12-07 |
JP6076592B2 (ja) | 2017-02-08 |
ATE503493T1 (de) | 2011-04-15 |
EP2281573A2 (en) | 2011-02-09 |
JP6211555B2 (ja) | 2017-10-11 |
US20070237788A1 (en) | 2007-10-11 |
JP2017186367A (ja) | 2017-10-12 |
EP1361890B1 (en) | 2011-03-30 |
JP2004532830A (ja) | 2004-10-28 |
JP2012046522A (ja) | 2012-03-08 |
EP1361890A2 (en) | 2003-11-19 |
EP2269639A2 (en) | 2011-01-05 |
JP5208347B2 (ja) | 2013-06-12 |
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