WO2003035695A3 - Agents that activate or inhibit toll-like receptor 9 - Google Patents

Agents that activate or inhibit toll-like receptor 9 Download PDF

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Publication number
WO2003035695A3
WO2003035695A3 PCT/US2002/023645 US0223645W WO03035695A3 WO 2003035695 A3 WO2003035695 A3 WO 2003035695A3 US 0223645 W US0223645 W US 0223645W WO 03035695 A3 WO03035695 A3 WO 03035695A3
Authority
WO
WIPO (PCT)
Prior art keywords
molecules
tlr9
bind
present
mimic
Prior art date
Application number
PCT/US2002/023645
Other languages
French (fr)
Other versions
WO2003035695A2 (en
Inventor
Ling-Ling An
Herren Wu
Michael S C Fung
Original Assignee
Tanox Inc
Ling-Ling An
Herren Wu
Michael S C Fung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanox Inc, Ling-Ling An, Herren Wu, Michael S C Fung filed Critical Tanox Inc
Priority to EP02795487A priority Critical patent/EP1412390A2/en
Priority to AU2002360243A priority patent/AU2002360243A1/en
Publication of WO2003035695A2 publication Critical patent/WO2003035695A2/en
Publication of WO2003035695A3 publication Critical patent/WO2003035695A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention includes molecules that bind to a peptidic segment on TLR9 and mimic the effects of the CpG motif. The CpG mimicking agents include, but are not limited to, antibodies, small-molecule compounds, peptides, peptide mimetics, and nucleic acids, including compositions comprising molecules that bind to a peptidic segment on TLR9 and mimic the effects of the CpG motif suitable for administering to a patient in need of treatment, optionally in combination with, for example, an excipient, diluant, or carrier. In addition, the present invention includes those molecules which bind to the TLR9's CXXC motifs at 255Cys-Arg-Arg 258Cys (as CRRC) or at 265Cys-Met-GIu 268Cys (as CMEC). The present invention includes methods for modulating the immune response by inducing a Th1-type response comprising administering molecules that bind to TLR9 and mimic CpG function. These molecules also shift the host cellular response away from a Th2-type response toward the Th1-type response. Thus, administering the molecules of the present invention that bind to TLR9 may avoid the risk of Th2-mediated, immunization-induced anaphylaxis, making this method useful in immunotherapy and asthma treatment. The molecules of the present invention may be administered in combination with a particular allergen.
PCT/US2002/023645 2001-07-26 2002-07-25 Agents that activate or inhibit toll-like receptor 9 WO2003035695A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP02795487A EP1412390A2 (en) 2001-07-26 2002-07-25 Agents that activate or inhibit toll-like receptor 9
AU2002360243A AU2002360243A1 (en) 2001-07-26 2002-07-25 Agents that activate or inhibit toll-like receptor 9

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30806801P 2001-07-26 2001-07-26
US60/308,068 2001-07-26

Publications (2)

Publication Number Publication Date
WO2003035695A2 WO2003035695A2 (en) 2003-05-01
WO2003035695A3 true WO2003035695A3 (en) 2003-11-13

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/023645 WO2003035695A2 (en) 2001-07-26 2002-07-25 Agents that activate or inhibit toll-like receptor 9

Country Status (4)

Country Link
EP (1) EP1412390A2 (en)
CN (1) CN1642982A (en)
AU (1) AU2002360243A1 (en)
WO (1) WO2003035695A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8883174B2 (en) 2009-03-25 2014-11-11 The Board Of Regents, The University Of Texas System Compositions for stimulation of mammalian innate immune resistance to pathogens

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EP1366077B1 (en) 2000-09-15 2011-05-25 Coley Pharmaceutical GmbH PROCESS FOR HIGH THROUGHPUT SCREENING OF CpG-BASED IMMUNO-AGONIST/ANTAGONIST
WO2003022296A1 (en) 2001-09-07 2003-03-20 The Trustees Of Boston University Method and composition for treating immune complex associated disorders
JP2007524615A (en) * 2003-06-20 2007-08-30 コーリー ファーマシューティカル ゲーエムベーハー Low molecular weight Toll-like receptor (TLR) antagonist
WO2005059517A2 (en) * 2003-12-16 2005-06-30 University Of Massachusetts Toll-like receptor assays
JP2008507530A (en) * 2004-07-20 2008-03-13 シェーリング　コーポレイション Induction of apoptosis in tumor cells expressing Toll-like receptors
US9636415B2 (en) 2006-03-03 2017-05-02 S-Target Therapeutics Gmbh Bispecific molecule binding TLR9 and CD32 and comprising a T cell epitope for treatment of allergies
EP1829895A1 (en) * 2006-03-03 2007-09-05 f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. Bispecific molecule binding TLR9 and CD32 and comprising a T cell epitope for treatment of allergies
CN101240271B (en) * 2006-08-28 2012-08-29 长春华普生物技术有限公司 Toll-like receptor adjustment oligonucleotide and use thereof
CN101134046B (en) * 2006-09-01 2011-10-05 中国医学科学院药物研究所 Application of TLR4 and TLR9 agonist compound in the restraint of tumour metastasis
WO2010030790A2 (en) * 2008-09-10 2010-03-18 The Texas A&M University System Methods and compositions for stimulation of mammalian innate immune resistance to pathogens
CN102803500B (en) 2009-06-05 2014-11-19 13治疗有限公司 Immunoregulatory peptides and methods of use
JP2013509869A (en) * 2009-11-05 2013-03-21 ノバルティス アーゲー Biomarkers for predicting fibrosis progression
CN101712957B (en) * 2009-11-25 2011-11-23 中国人民解放军第三军医大学第一附属医院 Toll-like receptor 9 (TLR9) blocking agent and application thereof
FR2975600B1 (en) 2011-05-24 2013-07-05 Assist Publ Hopitaux De Paris AGENTS FOR THE TREATMENT OF TUMORS
AR095882A1 (en) 2013-04-22 2015-11-18 Hoffmann La Roche ANTIBODY COMBINATION THERAPY AGAINST HUMAN CSF-1R WITH A TLR9 AGONIST
DK3143403T3 (en) 2014-05-16 2022-01-17 Ablynx Nv PROCEDURES FOR THE DETECTION AND / OR MEASUREMENT OF ANTI-DRUG ANTIBODIES, IN PARTICULAR, TREATMENT-INDUCTED ANTI-DRUG ANTIBODIES
ES2815572T3 (en) 2014-05-16 2021-03-30 Ablynx Nv Immunoglobulin variable domains
WO2016044839A2 (en) 2014-09-19 2016-03-24 The Board Of Regents Of The University Of Texas System Compositions and methods for treating viral infections through stimulated innate immunity in combination with antiviral compounds
EP3690030A4 (en) 2017-09-28 2021-06-23 Industry-Academic Cooperation Foundation, Yonsei University Method for producing myeloid-derived suppressor cells, myeloid-derived suppressor cells produced thereby, and uses thereof
WO2021207653A1 (en) * 2020-04-10 2021-10-14 Idera Pharmaceuticals, Inc. Use of a tlr9 agonist in methods for treating covid-19
AU2022277246A1 (en) * 2021-05-18 2024-01-04 Hung, Mien-Chie Vaccine, use thereof and cancer vaccine cocktail

Citations (3)

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Publication number Priority date Publication date Assignee Title
WO2001055386A1 (en) * 2000-01-25 2001-08-02 Glaxosmithkline Toll-like receptor
WO2001093905A1 (en) * 2000-06-08 2001-12-13 Intercell Biomedizinische Forschungs- Und Entwicklungs Ag Immunostimulatory oligodeoxynucleotides
WO2002006482A1 (en) * 2000-07-19 2002-01-24 Japan Science And Technology Corporation Receptor protein specifically recognizing bacterial dna

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001055386A1 (en) * 2000-01-25 2001-08-02 Glaxosmithkline Toll-like receptor
WO2001093905A1 (en) * 2000-06-08 2001-12-13 Intercell Biomedizinische Forschungs- Und Entwicklungs Ag Immunostimulatory oligodeoxynucleotides
WO2002006482A1 (en) * 2000-07-19 2002-01-24 Japan Science And Technology Corporation Receptor protein specifically recognizing bacterial dna

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HEMMI HIROAKI ET AL: "A Toll-like receptor recognizes bacterial DNA", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 408, no. 6813, 7 December 2000 (2000-12-07), pages 740 - 745, XP002168474, ISSN: 0028-0836 *
KRIEG A M ET AL: "CpG motifs in bacterial DNA trigger direct B-cell activation.", NATURE. ENGLAND 6 APR 1995, vol. 374, no. 6522, 6 April 1995 (1995-04-06), pages 546 - 549, XP002910391, ISSN: 0028-0836 *
WAGNER H: "Bacterial CpG DNA activates immune cells to signal infectious danger.", ADVANCES IN IMMUNOLOGY. UNITED STATES 1999, vol. 73, 1999, pages 329 - 368, XP009015569, ISSN: 0065-2776 *
WAGNER HERMANN: "Toll meets bacterial CpG-DNA.", IMMUNITY, vol. 14, no. 5, May 2001 (2001-05-01), pages 499 - 502, XP002250852, ISSN: 1074-7613 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8883174B2 (en) 2009-03-25 2014-11-11 The Board Of Regents, The University Of Texas System Compositions for stimulation of mammalian innate immune resistance to pathogens
US9186400B2 (en) 2009-03-25 2015-11-17 The Board Of Regents, The University Of Texas System Compositions for stimulation of mammalian innate immune resistance to pathogens
US9504742B2 (en) 2009-03-25 2016-11-29 The Board Of Regents, The University Of Texas System Compositions for stimulation of mammalian innate immune resistance to pathogens

Also Published As

Publication number Publication date
EP1412390A2 (en) 2004-04-28
CN1642982A (en) 2005-07-20
AU2002360243A1 (en) 2003-05-06
WO2003035695A2 (en) 2003-05-01

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