WO2004058807A3 - Mhc class i restricted t-cell stimulating peptides from hepatitis b virus - Google Patents

Mhc class i restricted t-cell stimulating peptides from hepatitis b virus Download PDF

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Publication number
WO2004058807A3
WO2004058807A3 PCT/EP2003/013948 EP0313948W WO2004058807A3 WO 2004058807 A3 WO2004058807 A3 WO 2004058807A3 EP 0313948 W EP0313948 W EP 0313948W WO 2004058807 A3 WO2004058807 A3 WO 2004058807A3
Authority
WO
WIPO (PCT)
Prior art keywords
hepatitis
virus
restricted
mhc class
cell stimulating
Prior art date
Application number
PCT/EP2003/013948
Other languages
French (fr)
Other versions
WO2004058807A2 (en
Inventor
Ignace Lasters
Johan Desmet
Toon Stegmann
Bernard Castelein
Original Assignee
Algonomics N V
Ignace Lasters
Johan Desmet
Toon Stegmann
Bernard Castelein
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Algonomics N V, Ignace Lasters, Johan Desmet, Toon Stegmann, Bernard Castelein filed Critical Algonomics N V
Priority to AU2003293807A priority Critical patent/AU2003293807A1/en
Publication of WO2004058807A2 publication Critical patent/WO2004058807A2/en
Publication of WO2004058807A3 publication Critical patent/WO2004058807A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention related to peptides which are suitable for inducing an immune response to HBV and to the use of said peptides for the preparations of vaccines, compositions and in methods of diagnosis. Said sequences of said peptides are predicted using a method of the invention.
PCT/EP2003/013948 2002-12-24 2003-12-09 Mhc class i restricted t-cell stimulating peptides from hepatitis b virus WO2004058807A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003293807A AU2003293807A1 (en) 2002-12-24 2003-12-09 Mhc class i restricted t-cell stimulating peptides from hepatitis b virus

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02447276.3 2002-12-24
EP02447276 2002-12-24

Publications (2)

Publication Number Publication Date
WO2004058807A2 WO2004058807A2 (en) 2004-07-15
WO2004058807A3 true WO2004058807A3 (en) 2004-09-30

Family

ID=32668936

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/013948 WO2004058807A2 (en) 2002-12-24 2003-12-09 Mhc class i restricted t-cell stimulating peptides from hepatitis b virus

Country Status (2)

Country Link
AU (1) AU2003293807A1 (en)
WO (1) WO2004058807A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102796172B (en) * 2011-05-23 2015-03-25 中国科学院微生物研究所 Hepatitis B virus (HBV) specific human leukocyte antigen-A33 (HLA-A33) restrictive epitope peptides and application thereof
JP7017012B2 (en) 2018-05-09 2022-02-08 ソウル大学校産学協力団 Hepatitis B virus-derived polypeptide and its antiviral use

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2926641A1 (en) * 2013-10-11 2015-04-16 Tarix Pharmaceuticals Ltd. Novel peptide compositions
US9133241B2 (en) 2013-10-11 2015-09-15 Tarix Pharmaceuticals Ltd. Peptide compositions
WO2015130488A2 (en) * 2014-02-28 2015-09-03 Immunotope, Inc. Mhc class i associated peptides for prevention and treatment of hepatitis b virus infection
EP3181146A1 (en) * 2015-12-16 2017-06-21 Ruprecht-Karls-Universität Heidelberg Cyclic ntcp-targeting peptides and their uses as entry inhibitors

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994020127A1 (en) * 1993-03-05 1994-09-15 Cytel Corporation Hla-a2.1 binding peptides and their uses
US5932224A (en) * 1991-08-26 1999-08-03 The Scripps Research Institute Peptides for inducing cytotoxic T lymphocyte responses to hepatitis B virus
US6117653A (en) * 1987-06-22 2000-09-12 Medeva Holdings B.V. Hepatitis B surface antigen vaccine
WO2002019986A1 (en) * 2000-09-08 2002-03-14 Epimmune Inc. Inducing cellular immune responses to hepatitis b virus using peptide and nucleic acid compositions

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6117653A (en) * 1987-06-22 2000-09-12 Medeva Holdings B.V. Hepatitis B surface antigen vaccine
US5932224A (en) * 1991-08-26 1999-08-03 The Scripps Research Institute Peptides for inducing cytotoxic T lymphocyte responses to hepatitis B virus
WO1994020127A1 (en) * 1993-03-05 1994-09-15 Cytel Corporation Hla-a2.1 binding peptides and their uses
WO2002019986A1 (en) * 2000-09-08 2002-03-14 Epimmune Inc. Inducing cellular immune responses to hepatitis b virus using peptide and nucleic acid compositions

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
LOGEAN A ET AL: "RECOVERY OF KNOW T-CELL EPITOPES BY COMPUTATIONAL SCANNING OF A VIRAL GENOME", JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, ESCOM SCIENCE PUBLISHERS BV, XX, vol. 16, no. 4, April 2002 (2002-04-01), pages 229 - 243, XP009008301, ISSN: 0920-654X *
NAYERSINA R ET AL: "HLA A2 RESTRICTED CYTOTOXIC T LYMPHOCYTE RESPONSES TO MULTIPLE HEPATITIS B SURFACE ANTIGEN EPITOPES DURING HEPATITIS B VIRUS INFECTION", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 150, no. 10, 15 May 1993 (1993-05-15), pages 4659 - 4671, XP000609159, ISSN: 0022-1767 *
TAN WEN SIANG: "Inhibition of hepatitis B virus assembly with synthetic peptides derived from the viral surface and core antigens", JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY, vol. 48, no. 2, April 2002 (2002-04-01), pages 103 - 107, XP009031079, ISSN: 0022-1260 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102796172B (en) * 2011-05-23 2015-03-25 中国科学院微生物研究所 Hepatitis B virus (HBV) specific human leukocyte antigen-A33 (HLA-A33) restrictive epitope peptides and application thereof
JP7017012B2 (en) 2018-05-09 2022-02-08 ソウル大学校産学協力団 Hepatitis B virus-derived polypeptide and its antiviral use

Also Published As

Publication number Publication date
WO2004058807A2 (en) 2004-07-15
AU2003293807A1 (en) 2004-07-22

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