WO2001007479A3 - Fragments of cellular prion protein and methods useful in the diagnosis and treatment of prion diseases - Google Patents

Fragments of cellular prion protein and methods useful in the diagnosis and treatment of prion diseases Download PDF

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Publication number
WO2001007479A3
WO2001007479A3 PCT/GB2000/002873 GB0002873W WO0107479A3 WO 2001007479 A3 WO2001007479 A3 WO 2001007479A3 GB 0002873 W GB0002873 W GB 0002873W WO 0107479 A3 WO0107479 A3 WO 0107479A3
Authority
WO
WIPO (PCT)
Prior art keywords
diagnosis
treatment
fragments
prion
methods useful
Prior art date
Application number
PCT/GB2000/002873
Other languages
French (fr)
Other versions
WO2001007479A2 (en
Inventor
John Collinge
Anthony Russel Clarke
Jonathan Peter Waltho
Graham Stuart Jackson
Laszio Luis Pereira Hosszu
Original Assignee
Imp College Innovations Ltd
John Collinge
Anthony Russel Clarke
Jonathan Peter Waltho
Graham Stuart Jackson
Laszio Luis Pereira Hosszu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9917491.4A external-priority patent/GB9917491D0/en
Priority claimed from GBGB9917878.2A external-priority patent/GB9917878D0/en
Application filed by Imp College Innovations Ltd, John Collinge, Anthony Russel Clarke, Jonathan Peter Waltho, Graham Stuart Jackson, Laszio Luis Pereira Hosszu filed Critical Imp College Innovations Ltd
Priority to BR0012765-5A priority Critical patent/BR0012765A/en
Priority to JP2001512562A priority patent/JP2003506327A/en
Priority to CA002379237A priority patent/CA2379237A1/en
Priority to AU64542/00A priority patent/AU780414B2/en
Priority to EP00951682A priority patent/EP1200469A2/en
Publication of WO2001007479A2 publication Critical patent/WO2001007479A2/en
Publication of WO2001007479A3 publication Critical patent/WO2001007479A3/en
Priority to NO20020207A priority patent/NO20020207L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The invention relates to peptides and binding agents such as antibodies and uses thereof, especially in medicine, notably in the treatment, prevention, and/or diagnosis of prion diseases.
PCT/GB2000/002873 1999-07-27 2000-07-25 Fragments of cellular prion protein and methods useful in the diagnosis and treatment of prion diseases WO2001007479A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
BR0012765-5A BR0012765A (en) 1999-07-27 2000-07-25 Peptide, methods of making an antibody, making a binding agent capable of binding to a cell form of a prion protein, removing a cell form of a prion protein from a sample, and using an antibody and / or binding agent, antibody, binding agent, use of an antibody or binding agent, kit, and, peptide sequence of a cellular form of a prion protein
JP2001512562A JP2003506327A (en) 1999-07-27 2000-07-25 Biological substances and methods that can be used for diagnosis and treatment of diseases
CA002379237A CA2379237A1 (en) 1999-07-27 2000-07-25 Fragments of cellular prion protein and methods useful in the diagnosis and treatment of prion diseases
AU64542/00A AU780414B2 (en) 1999-07-27 2000-07-25 Fragments of cellular prion protein and methods useful in the diagnosis and treatment of prion diseases
EP00951682A EP1200469A2 (en) 1999-07-27 2000-07-25 Fragments of cellular prion protein and methods useful in the diagnosis and treatment of prion diseases
NO20020207A NO20020207L (en) 1999-07-27 2002-01-15 Biological materials and methods useful in the diagnosis and treatment of disease

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9917491.4A GB9917491D0 (en) 1999-07-27 1999-07-27 Biological materials and methods useful in the diagnosis and treastment of diseases
GB9917491.4 1999-07-27
GBGB9917878.2A GB9917878D0 (en) 1999-07-30 1999-07-30 Biological materials and methods useful in the diagnosis and treatment of diseases
GB9917878.2 1999-07-30

Publications (2)

Publication Number Publication Date
WO2001007479A2 WO2001007479A2 (en) 2001-02-01
WO2001007479A3 true WO2001007479A3 (en) 2001-08-23

Family

ID=26315795

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/002873 WO2001007479A2 (en) 1999-07-27 2000-07-25 Fragments of cellular prion protein and methods useful in the diagnosis and treatment of prion diseases

Country Status (7)

Country Link
EP (1) EP1200469A2 (en)
JP (1) JP2003506327A (en)
AU (1) AU780414B2 (en)
BR (1) BR0012765A (en)
CA (1) CA2379237A1 (en)
NO (1) NO20020207L (en)
WO (1) WO2001007479A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3495738B2 (en) 1995-09-14 2004-02-09 ザ レジェンツ オブ ザ ユニバーシティー オブ カリフォルニア Natural PrPsc-specific antibody
US6537548B1 (en) 2000-07-27 2003-03-25 The Regents Of The University Of California Antibodies specific for ungulate PrP
CA2448981C (en) 2001-05-31 2014-03-18 Arete Associates Misfolded protein sensor method
US20050026165A1 (en) 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
GB0227651D0 (en) * 2002-11-27 2003-01-08 Medical Res Council Prion
EP1457500A1 (en) * 2003-03-14 2004-09-15 University of Zurich Soluble hybrid prion proteins and their use in the diagnosis, prevention and treatment of transmissible spongiform encephalophathies
NZ580256A (en) 2003-08-13 2011-07-29 Novartis Vaccines & Diagnostic Prion-specific peptide reagents comprising the sequence KKRPKPGG
US8372593B2 (en) 2005-02-15 2013-02-12 Adlyfe, Inc. Method for detecting misfolded proteins and prions
EP1931695B1 (en) 2005-09-09 2013-04-10 Novartis AG Prion-specific peptoid reagents
WO2008013859A2 (en) 2006-07-28 2008-01-31 Adlyfe, Inc. Peptide probes for diagnostics and therapeutics

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998037210A1 (en) * 1997-02-21 1998-08-27 KANTON ZÜRICH vertreten durch DIE ERZIEHUNGSDIREKTION Immunological detection of prions
WO1998055132A1 (en) * 1997-06-02 1998-12-10 The Regents Of The University Of California Prion protein modulator factor (ppmf) and prion resistant animals

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998037210A1 (en) * 1997-02-21 1998-08-27 KANTON ZÜRICH vertreten durch DIE ERZIEHUNGSDIREKTION Immunological detection of prions
WO1998055132A1 (en) * 1997-06-02 1998-12-10 The Regents Of The University Of California Prion protein modulator factor (ppmf) and prion resistant animals

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; August 1999 (1999-08-01), HOSSZU LASZLO L P ET AL: "Structural mobility of the human prion protein probed by backbone hydrogen exchange.", XP002158408, Database accession no. PREV199900385677 *
NATURE STRUCTURAL BIOLOGY, vol. 6, no. 8, August 1999 (1999-08-01), pages 740 - 743, ISSN: 1072-8368 *
SCOTT MICHAEL R ET AL: "Identification of a prion protein epitope modulating transmission of bovine spongiform encephalopathy prions to transgenic mice.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 94, no. 26, 23 December 1997 (1997-12-23), Dec. 23, 1997, pages 14279 - 14284, XP002158407, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
AU780414B2 (en) 2005-03-17
JP2003506327A (en) 2003-02-18
AU6454200A (en) 2001-02-13
NO20020207L (en) 2002-03-14
NO20020207D0 (en) 2002-01-15
EP1200469A2 (en) 2002-05-02
WO2001007479A2 (en) 2001-02-01
BR0012765A (en) 2002-04-02
CA2379237A1 (en) 2001-02-01

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