RU2020113032A - Новые пептиды и комбинации пептидов для применения в иммунотерапии рака легких, в том числе немелкоклеточного рака легких (нмрл) и других видов рака - Google Patents
Новые пептиды и комбинации пептидов для применения в иммунотерапии рака легких, в том числе немелкоклеточного рака легких (нмрл) и других видов рака Download PDFInfo
- Publication number
- RU2020113032A RU2020113032A RU2020113032A RU2020113032A RU2020113032A RU 2020113032 A RU2020113032 A RU 2020113032A RU 2020113032 A RU2020113032 A RU 2020113032A RU 2020113032 A RU2020113032 A RU 2020113032A RU 2020113032 A RU2020113032 A RU 2020113032A
- Authority
- RU
- Russia
- Prior art keywords
- peptide
- seq
- cancer
- paragraphs
- nucleic acid
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims 30
- 206010028980 Neoplasm Diseases 0.000 title claims 6
- 201000011510 cancer Diseases 0.000 title claims 5
- 206010058467 Lung neoplasm malignant Diseases 0.000 title claims 2
- 201000005202 lung cancer Diseases 0.000 title claims 2
- 208000020816 lung neoplasm Diseases 0.000 title claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 title 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 title 2
- 238000002619 cancer immunotherapy Methods 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 claims 10
- 108020004707 nucleic acids Proteins 0.000 claims 9
- 102000039446 nucleic acids Human genes 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 8
- 239000013604 expression vector Substances 0.000 claims 8
- 239000000427 antigen Substances 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 3
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 2
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 2
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 230000014509 gene expression Effects 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 108010028930 invariant chain Proteins 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 102000008949 Histocompatibility Antigens Class I Human genes 0.000 claims 1
- 108010088652 Histocompatibility Antigens Class I Proteins 0.000 claims 1
- 102000018713 Histocompatibility Antigens Class II Human genes 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 102000043129 MHC class I family Human genes 0.000 claims 1
- 108091054437 MHC class I family Proteins 0.000 claims 1
- 108091054438 MHC class II family Proteins 0.000 claims 1
- 108700018351 Major Histocompatibility Complex Proteins 0.000 claims 1
- 208000002030 Merkel cell carcinoma Diseases 0.000 claims 1
- 206010029266 Neuroendocrine carcinoma of the skin Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 208000017763 cutaneous neuroendocrine carcinoma Diseases 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 230000002018 overexpression Effects 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464499—Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/804—Blood cells [leukemia, lymphoma]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/812—Breast
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/82—Colon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/828—Stomach
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/836—Intestine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/844—Liver
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/852—Pancreas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/86—Lung
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/868—Vaccine for a specifically defined cancer kidney
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/876—Skin, melanoma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/884—Vaccine for a specifically defined cancer prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/892—Reproductive system [uterus, ovaries, cervix, testes]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/106—Plasmid DNA for vertebrates
- C12N2800/107—Plasmid DNA for vertebrates for mammalian
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
Claims (32)
1. Пептид, который связывается с молекулой(ами) главного комплекса гистосовместимости (MHC), выбранный из группы:
(а) пептид, состоящий из аминокислотной последовательности в соответствии с любой из SEQ ID NO: 1 по SEQ ID NO: 29 или SEQ ID NO: 31 по SEQ ID NO: 162, необязательно удлиненной на 1 аминокислоту на его N- и/или C-концевом участке;
(б) пептид в соответствии с (а), где указанный пептид включает непептидные связи.
2. Пептид по п. 1, где указанный пептид имеет способность связываться с молекулой MHC I класса, и где указанный пептид, когда он связан с указанной молекулой MHC, в состоянии распознаваться Т-клетками CD8.
3. Пептид по п.1 или 2, где указанный пептид состоит или состоит по существу из аминокислотной последовательности SEQ ID NO: 1 по SEQ ID NO: 29 или SEQ ID NO: 31 по SEQ ID NO: 162.
4. Пептид по любому из пп. 1–3 для применения в медицине.
5. Слитый белок, который связывается с молекулой(ами) MHC, включающий пептид по п. 1 (а), слитый с N-терминальными аминокислотами антиген-ассоциированной инвариантной цепи (Ii) HLA-DR.
6. Применение пептида по п. 1 (а) для получения антитела, растворимого или связанного с мембраной, которое специфически связывает пептид по любому из пп. 1–4, когда он связан с молекулой MHC.
7. Нуклеиновая кислота, кодирующая пептид по любому из пп. 1–4.
8. Нуклеиновая кислота по п. 7 для применения в медицине.
9. Вектор экспрессии, экспрессирующий нуклеиновую кислоту по п. 7.
10. Вектор экспрессии по п. 9 для применения в медицине.
11. Рекомбинантная клетка-хозяин, экспрессирующая пептид по любому из пп. 1–4, или включающая нуклеиновую кислоту по п. 7 для экспрессии пептида по любому из пп. 1–4, или включающая вектор экспрессии по п. 9 для экспрессии пептида по любому из пп. 1–4, где указанная клетка-хозяин предпочтительно является антигенпрезентирующей клеткой, такой как дендритная клетка.
12. Клетка-хозяин по п. 11 для применения в медицине.
13. Способ получения пептида по любому из пп. 1–4, включающий культивацию клетки-хозяина по п. 11, которая презентирует пептид по любому из пп. 1–4 или экспрессирует нуклеиновую кислоту по п. 7 или вмещает вектор экспрессии по п. 9, и выделение пептида из клетки-хозяина или его культуральной среды.
14. Способ получения активированных T-лимфоцитов in vitro, включающий контактирование Т-клеток in vitro с нагруженными антигеном молекулами MHC человека I или II класса, экспрессированными на поверхности подходящей антигенпрезентирующей клетки или искусственной конструкции, имитирующей антигенпрезентирующую клетку, в течение периода времени, достаточного для активации указанных Т-клеток антиген-специфическим образом, где указанный антиген является пептидом по любому из пп. 1–4.
15. Применение пептида по любому из пп. 1–4, нуклеиновой кислоты по п. 7, вектора экспрессии по п. 9, или клетки по п. 11 для лечения рака.
16. Применение по п. 15, где указанный рак выбран из следующей группы: рак легких, рак головного мозга, рак молочной железы, колоректальный рак, рак пищевода, рак почки, рак печени, рак яичника, рак поджелудочной железы, рак предстательной железы, рак желудка, меланома, карцинома клеток Меркеля, лейкоз (ОМЛ, ХЛЛ) и другие опухоли, которые демонстрируют избыточную экспрессию белка, из которого образован пептид с SEQ ID NO: 1 по SEQ ID NO: 29 или SEQ ID NO: 31 по SEQ ID NO: 162.
17. Набор для лечения рака, включающий:
(а) контейнер, содержащий пептид(ы) по любому из пп. 1–4, нуклеиновую(ые) кислоту(ы) по п. 7, вектор(ы) экспрессии по п. 9 или клетку(и) по п. 11, в виде раствора или в лиофилизированной форме;
(б) второй контейнер, содержащий разбавитель или восстанавливающий раствор для лиофилизированного состава;
(в) необязательно – по меньшей мере еще один пептид, выбранный из группы, состоящей из SEQ ID NО: 1 по 162, и
(г) необязательно – инструкции по (i) применению раствора или (ii) восстановлению и/или по применению лиофилизированного состава.
18. Набор по п. 17, дополнительно включающий один или более из (iii) буфера, (iv) разбавителя, (v) фильтра, (vi) иглы или (v) шприца.
19. Набор по п. 17 или 18, где указанный пептид состоит из SEQ ID NO: 1 по SEQ ID NO: 29 или SEQ ID NO: 31 по SEQ ID NO: 162.
20. Фармацевтическая композиция для лечения рака, включающая по меньшей мере один активный ингредиент, выбранный из группы, состоящей из:
а) пептида, состоящего из SEQ ID NO: 1 по SEQ ID NO: 29 или SEQ ID NO: 31 по SEQ ID NO: 162;
б) слитого белка, включающего пептид в соответствии с a) и 1–80 N-терминальных аминокислот антиген-ассоциированной инвариантной цепи HLA-DR (Ii);
в) нуклеиновой кислоты, кодирующей любой из ингредиентов a) или б), или вектора экспрессии, включающего указанную нуклеиновую кислоту,
г) клетки-хозяина, включающей вектор экспрессии в соответствии с в),
д) конъюгированного или меченого пептида или каркаса в соответствии с любым из пунктов а)–г)
и фармацевтически приемлемый носитель и, необязательно, фармацевтически приемлемые вспомогательные вещества и/или стабилизаторы.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562152258P | 2015-04-24 | 2015-04-24 | |
US62/152,258 | 2015-04-24 | ||
GB1507030.3 | 2015-04-24 | ||
GBGB1507030.3A GB201507030D0 (en) | 2015-04-24 | 2015-04-24 | Immunotherapy against lung cancers, in particular NSCLC |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2017137142A Division RU2723092C2 (ru) | 2015-04-24 | 2016-04-22 | Новые пептиды и комбинации пептидов для применения в иммунотерапии рака легких, в том числе немелкоклеточного рака легких (нмрл) и других видов рака |
Publications (1)
Publication Number | Publication Date |
---|---|
RU2020113032A true RU2020113032A (ru) | 2020-05-14 |
Family
ID=53488628
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2020113032A RU2020113032A (ru) | 2015-04-24 | 2016-04-22 | Новые пептиды и комбинации пептидов для применения в иммунотерапии рака легких, в том числе немелкоклеточного рака легких (нмрл) и других видов рака |
RU2017137142A RU2723092C2 (ru) | 2015-04-24 | 2016-04-22 | Новые пептиды и комбинации пептидов для применения в иммунотерапии рака легких, в том числе немелкоклеточного рака легких (нмрл) и других видов рака |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2017137142A RU2723092C2 (ru) | 2015-04-24 | 2016-04-22 | Новые пептиды и комбинации пептидов для применения в иммунотерапии рака легких, в том числе немелкоклеточного рака легких (нмрл) и других видов рака |
Country Status (27)
Country | Link |
---|---|
US (16) | US10925948B2 (ru) |
EP (5) | EP3750559A1 (ru) |
JP (3) | JP6901065B2 (ru) |
KR (1) | KR20170137119A (ru) |
CN (4) | CN112661838A (ru) |
AR (1) | AR104675A1 (ru) |
AU (6) | AU2016251621B2 (ru) |
BR (1) | BR112017017560A2 (ru) |
CA (1) | CA2983064A1 (ru) |
CL (8) | CL2017001819A1 (ru) |
CO (1) | CO2017008902A2 (ru) |
EA (1) | EA201792044A1 (ru) |
GB (1) | GB201507030D0 (ru) |
HK (1) | HK1244666A1 (ru) |
IL (2) | IL292411A (ru) |
MA (5) | MA51763A (ru) |
MX (2) | MX2017013688A (ru) |
MY (1) | MY173099A (ru) |
NZ (1) | NZ734197A (ru) |
PE (2) | PE20171765A1 (ru) |
PH (1) | PH12017501275A1 (ru) |
RU (2) | RU2020113032A (ru) |
SG (2) | SG11201704966YA (ru) |
TW (2) | TW202130658A (ru) |
UA (1) | UA122675C2 (ru) |
WO (1) | WO2016170139A1 (ru) |
ZA (1) | ZA201704939B (ru) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201511546D0 (en) | 2015-07-01 | 2015-08-12 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers |
EP3919507A3 (en) | 2015-07-01 | 2022-01-12 | Immatics Biotechnologies GmbH | Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers |
GB201512369D0 (en) | 2015-07-15 | 2015-08-19 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against epithelial ovarian cancer and other cancers |
RU2729116C2 (ru) | 2015-12-16 | 2020-08-04 | Гритстоун Онколоджи, Инк. | Идентификация, производство и применение неоантигенов |
US20190117751A1 (en) | 2015-12-28 | 2019-04-25 | Sapporo Medical University | Tumor antigen peptide |
GB201609193D0 (en) | 2016-05-25 | 2016-07-06 | Immatics Biotechnologies Gmbh | Novel peptides, combination of peptides as targets for use in immunotherapy against gallbladder cancer and cholangiocarcinoma and other cancers |
JP7075125B2 (ja) | 2016-05-25 | 2022-05-25 | イマティクス バイオテクノロジーズ ゲーエムベーハー | 標的としてのおよび胆嚢がんおよび胆管がんおよびその他のがんに対する免疫療法で使用するための新規ペプチド、ペプチド組み合わせ |
DE102016123893A1 (de) | 2016-12-08 | 2018-06-14 | Immatics Biotechnologies Gmbh | T-Zellrezeptoren mit verbesserter Bindung |
EP4317432A3 (en) | 2016-12-08 | 2024-04-17 | Immatics Biotechnologies GmbH | T cell receptors with improved pairing |
US10899819B2 (en) | 2017-04-10 | 2021-01-26 | Immatics Biotechnologies Gmbh | Peptides and combination of peptides for use in immunotherapy against leukemias and other cancers |
MA49122A (fr) * | 2017-04-10 | 2021-03-24 | Immatics Biotechnologies Gmbh | Peptides et combinaisons de peptides destinés à être utilisés en immunothérapie anticancéreuse |
EP3609531A2 (en) | 2017-04-10 | 2020-02-19 | immatics biotechnologies GmbH | Peptides and combination of peptides for use in immunotherapy against leukemias and other cancers |
TW201841934A (zh) | 2017-04-10 | 2018-12-01 | 德商英麥提克生物技術股份有限公司 | 用於治療癌症免疫治療的新穎肽及其肽組合物 |
US10800823B2 (en) * | 2017-07-07 | 2020-10-13 | Immatics Biotechnologies Gmbh | Peptides and combination of peptides for use in immunotherapy against lung cancer, including NSCLC, SCLC and other cancers |
EP3428194B1 (en) | 2017-07-14 | 2021-08-18 | Immatics Biotechnologies GmbH | Improved dual specificity polypeptide molecule |
DE102017115966A1 (de) | 2017-07-14 | 2019-01-17 | Immatics Biotechnologies Gmbh | Polypeptidmolekül mit verbesserter zweifacher Spezifität |
KR20200087143A (ko) | 2017-10-10 | 2020-07-20 | 그릿스톤 온콜로지, 인코포레이티드 | 핫스팟을 이용한 신생항원 동정 |
JP2021503897A (ja) | 2017-11-22 | 2021-02-15 | グリットストーン オンコロジー インコーポレイテッド | 新生抗原のためのジャンクションエピトープ提示の低減 |
KR102417088B1 (ko) * | 2018-02-09 | 2022-07-07 | 제넨테크, 인크. | 비만 세포 매개 염증성 질환에 대한 치료 및 진단 방법 |
TW202016131A (zh) * | 2018-05-16 | 2020-05-01 | 德商英麥提克生物技術股份有限公司 | 用於抗癌免疫治療的肽 |
CN109116023B (zh) * | 2018-06-14 | 2021-06-04 | 郑州大学第一附属医院 | 一种肺癌标志物抗-mmp12自身抗体及其应用 |
CA3110760A1 (en) | 2018-09-04 | 2020-03-12 | Treos Bio Limited | Peptide vaccines |
CN110706742B (zh) * | 2019-09-30 | 2020-06-30 | 中生康元生物科技(北京)有限公司 | 泛癌种肿瘤新生抗原高通量预测方法及其应用 |
CN111233972B (zh) * | 2020-01-19 | 2021-08-10 | 华南理工大学 | 一种抗炎三肽及其提取分离方法和在改善记忆中的应用 |
CN111575283A (zh) * | 2020-04-20 | 2020-08-25 | 中山大学肿瘤防治中心 | Dkc1特异小干扰rna及其应用 |
CA3188501A1 (en) * | 2020-08-07 | 2022-02-10 | Todd Golub | Therapeutic targeting of phosphate dysregulation in cancer via the xpr1:kidins220 protein complex |
US11885886B2 (en) | 2020-10-23 | 2024-01-30 | Ford Global Technologies, Llc | Systems and methods for camera-LiDAR fused object detection with LiDAR-to-image detection matching |
US11430224B2 (en) | 2020-10-23 | 2022-08-30 | Argo AI, LLC | Systems and methods for camera-LiDAR fused object detection with segment filtering |
CN113185597B (zh) * | 2021-04-06 | 2022-08-23 | 中山大学孙逸仙纪念医院 | 一种可激活患者的抗肿瘤免疫反应的人肿瘤抗原及其应用 |
CN113181350B (zh) * | 2021-04-27 | 2023-04-25 | 浙江大学 | 以活化成纤维fap为基础的肽类疫苗及其制备方法 |
CN113136434A (zh) * | 2021-05-14 | 2021-07-20 | 北京化工大学 | Lpcat1基因在制备治疗癌症药物及诊断性试剂盒中的应用 |
KR20240046502A (ko) * | 2021-08-20 | 2024-04-09 | 후닐라이프 바이오테크놀로지, 인코포레이트 | 섬유성 질환 치료에 있어서 알파-에놀라제 길항제의 이용 |
WO2023039161A1 (en) * | 2021-09-09 | 2023-03-16 | Kartos Therapeutics | Methods of treating cancer dependent on myc gene expresssion |
IT202100024779A1 (it) * | 2021-09-28 | 2023-03-28 | Univ Degli Studi Di Torino | Vaccino a DNA per l’uso nel trattamento profilattico o terapeutico dell’adenocarcinoma duttale pancreatico |
CN113995841A (zh) * | 2021-11-04 | 2022-02-01 | 上海市胸科医院 | Mettl3/alkbh5/eno1调控轴作为靶位点在制备治疗肺腺癌药物中的应用 |
WO2023180552A1 (en) * | 2022-03-24 | 2023-09-28 | Institut Curie | Immunotherapy targeting tumor transposable element derived neoantigenic peptides in glioblastoma |
CN114957399B (zh) * | 2022-06-29 | 2023-05-09 | 湖北工业大学 | 一种多肽、多肽衍生物及其在制备抗肿瘤药物中的应用 |
CN116059361B (zh) * | 2023-02-27 | 2023-08-15 | 华中科技大学协和深圳医院 | 三价铬离子和/或金属铬在制备肿瘤免疫治疗药物中的应用 |
CN116270523B (zh) * | 2023-05-15 | 2023-08-08 | 四川厌氧生物科技有限责任公司 | 一种耐酸的口服双层胶囊及其制备方法 |
Family Cites Families (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA92037A (en) | 1904-11-25 | 1905-03-07 | The Hooven, Owens, Rentchler Company | Turbine bearings |
US4440859A (en) | 1977-05-27 | 1984-04-03 | The Regents Of The University Of California | Method for producing recombinant bacterial plasmids containing the coding sequences of higher organisms |
US4704362A (en) | 1977-11-08 | 1987-11-03 | Genentech, Inc. | Recombinant cloning vehicle microbial polypeptide expression |
NO794196L (no) | 1978-12-22 | 1980-06-24 | Biogen Nv | Fremgangsmaate ved fremstilling av et rekombinert dna molekyl |
US4530901A (en) | 1980-01-08 | 1985-07-23 | Biogen N.V. | Recombinant DNA molecules and their use in producing human interferon-like polypeptides |
US4342566A (en) | 1980-02-22 | 1982-08-03 | Scripps Clinic & Research Foundation | Solid phase anti-C3 assay for detection of immune complexes |
US4678751A (en) | 1981-09-25 | 1987-07-07 | Genentech, Inc. | Hybrid human leukocyte interferons |
US4766075A (en) | 1982-07-14 | 1988-08-23 | Genentech, Inc. | Human tissue plasminogen activator |
US4582800A (en) | 1982-07-12 | 1986-04-15 | Hoffmann-La Roche Inc. | Novel vectors and method for controlling interferon expression |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4757006A (en) | 1983-10-28 | 1988-07-12 | Genetics Institute, Inc. | Human factor VIII:C gene and recombinant methods for production |
US4677063A (en) | 1985-05-02 | 1987-06-30 | Cetus Corporation | Human tumor necrosis factor |
US4810648A (en) | 1986-01-08 | 1989-03-07 | Rhone Poulenc Agrochimie | Haloarylnitrile degrading gene, its use, and cells containing the gene |
US4897445A (en) | 1986-06-27 | 1990-01-30 | The Administrators Of The Tulane Educational Fund | Method for synthesizing a peptide containing a non-peptide bond |
US6252052B1 (en) | 1996-10-03 | 2001-06-26 | Cornell Research Foundation, Inc | Antibodies which bind to NY-ESO-1 cancer associated proteins, and hybridomas which produce these antibodies |
RU2139092C1 (ru) | 1993-06-03 | 1999-10-10 | Терапьютик Антибодиз Инк. | Фрагменты антител в терапии |
AUPM322393A0 (en) | 1993-12-24 | 1994-01-27 | Austin Research Institute, The | Mucin carbohydrate compounds and their use in immunotherapy |
WO1997026328A1 (en) | 1996-01-17 | 1997-07-24 | Imperial College Innovations Limited | Immunotherapy using cytotoxic t lymphocytes (ctl) |
US5849589A (en) | 1996-03-11 | 1998-12-15 | Duke University | Culturing monocytes with IL-4, TNF-α and GM-CSF TO induce differentiation to dendric cells |
US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
US6221585B1 (en) * | 1998-01-15 | 2001-04-24 | Valigen, Inc. | Method for identifying genes underlying defined phenotypes |
US7579160B2 (en) | 1998-03-18 | 2009-08-25 | Corixa Corporation | Methods for the detection of cervical cancer |
US20030236209A1 (en) * | 1998-03-18 | 2003-12-25 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
US6703491B1 (en) * | 1999-03-17 | 2004-03-09 | Exelixis, Inc. | Drosophila sequences |
EP1175503A1 (en) * | 1999-04-09 | 2002-01-30 | Human Genome Sciences, Inc. | 49 human secreted proteins |
CA2311201A1 (en) * | 1999-08-05 | 2001-02-05 | Genset S.A. | Ests and encoded human proteins |
EP1259545A2 (en) | 2000-01-21 | 2002-11-27 | Ludwig Institute For Cancer Research | Small cell lung cancer associated antigens and uses therefor |
US20040191260A1 (en) | 2003-03-26 | 2004-09-30 | Technion Research & Development Foundation Ltd. | Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof |
JP2004503213A (ja) | 2000-03-27 | 2004-02-05 | テクニオン リサーチ アンド ディベロップメント ファウンデーション リミテッド | 1本鎖クラスi主要組織適合性複合体、それをコードする構築物およびそれを生成する方法 |
CN1464790A (zh) | 2000-06-05 | 2003-12-31 | 苏诺尔分子公司 | T细胞受体融合物及共轭物以及其使用方法 |
MXPA03009510A (es) * | 2001-04-17 | 2005-04-29 | Univ Arkansas | Secuencias de repeticion del gen ca125 y su uso para intervenciones de diagnosticos y terapeuticas. |
US7892559B2 (en) | 2002-01-30 | 2011-02-22 | Survac Aps | Survivin-derived peptides and use thereof |
EP1332760A1 (en) * | 2002-02-04 | 2003-08-06 | Academisch Ziekenhuis Leiden | Novel epitopes for celiac disease and autoimmune diseases, methods for detecting those and novel non-antigenic food compounds |
US6992176B2 (en) | 2002-02-13 | 2006-01-31 | Technion Research & Development Foundation Ltd. | Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease |
WO2003070752A2 (en) | 2002-02-20 | 2003-08-28 | Dyax Corporation | Mhc-peptide complex binding ligands |
ATE402956T1 (de) * | 2002-10-02 | 2008-08-15 | Hoffmann La Roche | Neue, mhc klasse ii assoziierte peptide |
NZ539225A (en) | 2002-10-09 | 2006-09-29 | Avidex Ltd | Single chain recombinant T cell receptors |
ATE432290T1 (de) | 2002-11-09 | 2009-06-15 | Immunocore Ltd | T ZELL REZEPTOR ßDISPLAYß |
GB0304068D0 (en) | 2003-02-22 | 2003-03-26 | Avidex Ltd | Substances |
CN100393745C (zh) | 2005-05-27 | 2008-06-11 | 北京大学 | 一种肿瘤抗原蛋白质和肿瘤抗原肽 |
ES2330013T3 (es) * | 2005-09-05 | 2009-12-03 | Immatics Biotechnologies Gmbh | Peptidos asociados a tumores unidos a moleculas del antigeno de leucocito humano (hla) de clase i o ii y vacunas contra el cancer relacionadas. |
EP1806359B1 (en) | 2005-09-05 | 2010-03-17 | Immatics Biotechnologies GmbH | Tumor-associated peptides binding promiscuously to human leukocyte antigen (HLA) class II molecules |
US20070292869A1 (en) * | 2006-03-02 | 2007-12-20 | Ppd Biomarker Discovery Sciences, Llc | Compositions and Methods for Analyzing Renal Cancer |
EP2057465A4 (en) * | 2006-08-09 | 2010-04-21 | Homestead Clinical Corp | SPECIFIC ORGAN PROTEINS AND METHODS OF USE |
EP2565204B1 (en) | 2007-07-27 | 2015-10-07 | immatics biotechnologies GmbH | Novel immunogenic epitopes for immunotherapy |
WO2009038756A2 (en) * | 2007-09-20 | 2009-03-26 | The J. David Gladstone Institutes | Long interspersed nuclear element polypeptide compositions and methods of use thereof |
EP2227556B1 (en) | 2007-11-19 | 2014-08-27 | Celera Corporation | Lung cancer markers and uses thereof |
WO2009075883A2 (en) * | 2007-12-12 | 2009-06-18 | University Of Georgia Research Foundation, Inc. | Glycoprotein cancer biomarker |
WO2009126805A2 (en) | 2008-04-11 | 2009-10-15 | The Board Of Regents Of The Univeristy Of Texas System | Therapeutic tarageting of mmps in neutral liposomes |
US20090263574A1 (en) | 2008-04-21 | 2009-10-22 | Quinn Daniel E | Method of restoring an article |
ITMI20081119A1 (it) * | 2008-06-19 | 2009-12-20 | Menarini Internat Operation Luxembourg Sa | Frammenti di muc16 ad attivita antigenica e composizioni farmaceutiche che li contengono |
JP5825673B2 (ja) * | 2009-05-15 | 2015-12-02 | Necソリューションイノベータ株式会社 | ペプチドを認識するアプタマー |
EP2470200B1 (en) | 2009-08-26 | 2017-03-15 | Immunotope, Inc. | Cytotoxic t-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of cancer |
GB201019331D0 (en) * | 2010-03-19 | 2010-12-29 | Immatics Biotechnologies Gmbh | Methods for the diagnosis and treatment of cancer based on AVL9 |
GB201004551D0 (en) * | 2010-03-19 | 2010-05-05 | Immatics Biotechnologies Gmbh | NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer |
GB201004575D0 (en) * | 2010-03-19 | 2010-05-05 | Immatics Biotechnologies Gmbh | Composition of tumor associated peptides and related anti cancer vaccine for the treatment of gastric cancer and other cancers |
WO2011119484A1 (en) * | 2010-03-23 | 2011-09-29 | Iogenetics, Llc | Bioinformatic processes for determination of peptide binding |
GB201006360D0 (en) | 2010-04-16 | 2010-06-02 | Immatics Biotechnologies Gmbh | Method for differentially quantifying naturally processed HLA-restricted peptides for cancer, autoimmune and infectious diseases immunotherapy development |
CN103180730B (zh) | 2010-05-14 | 2016-03-02 | 综合医院公司 | 鉴定肿瘤特异性新抗原的组合物和方法 |
WO2012048291A2 (en) | 2010-10-08 | 2012-04-12 | Proteapex Therapeutics Llc | Compositions and methods for inhibition of mmp:mmp-substrate interactions |
WO2012056407A1 (en) | 2010-10-26 | 2012-05-03 | Technion Research & Development Foundation Ltd. | Antibodies which bind soluble t-cell receptor ligands |
WO2012100023A1 (en) | 2011-01-19 | 2012-07-26 | Thomas Jefferson University | Detection of pancreatic ductal adenocarcinoma |
EA201490520A1 (ru) | 2011-09-07 | 2014-09-30 | Мидатек Лимитед | Противоопухолевые вакцины на основе наночастиц |
WO2013057586A1 (en) | 2011-10-19 | 2013-04-25 | Oslo Universitetssykehus Hf | Compositions and methods for producing soluble t - cell receptors |
US20190292535A1 (en) | 2012-11-08 | 2019-09-26 | Roche Diagnostics Operations, Inc. | Nucleic acids encoding chimeric polypeptides for library screening |
TWI627182B (zh) | 2013-05-24 | 2018-06-21 | 腫瘤療法 科學股份有限公司 | 對於th1細胞之imp-3抗原決定位胜肽及含此之疫苗 |
EP2808392A1 (en) | 2013-05-28 | 2014-12-03 | Rheinische Friedrich-Wilhelms-Universität Bonn | Aptamers and use of the aptamers in the diagnosis and treatment of cancer |
TWI777198B (zh) | 2013-08-05 | 2022-09-11 | 德商伊瑪提克斯生物科技有限公司 | 新穎肽類,細胞及其用於治療多種腫瘤的用途,其製造方法及包含其等之醫藥組成物(七) |
GB201512369D0 (en) * | 2015-07-15 | 2015-08-19 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against epithelial ovarian cancer and other cancers |
GB201515321D0 (en) * | 2015-08-28 | 2015-10-14 | Immatics Biotechnologies Gmbh | Novel peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers |
-
2015
- 2015-04-24 GB GBGB1507030.3A patent/GB201507030D0/en not_active Ceased
-
2016
- 2016-04-22 PE PE2017001272A patent/PE20171765A1/es unknown
- 2016-04-22 RU RU2020113032A patent/RU2020113032A/ru unknown
- 2016-04-22 SG SG11201704966YA patent/SG11201704966YA/en unknown
- 2016-04-22 CA CA2983064A patent/CA2983064A1/en active Pending
- 2016-04-22 PE PE2022002861A patent/PE20230768A1/es unknown
- 2016-04-22 US US16/305,686 patent/US10925948B2/en active Active
- 2016-04-22 WO PCT/EP2016/059053 patent/WO2016170139A1/en active Application Filing
- 2016-04-22 UA UAA201705953A patent/UA122675C2/uk unknown
- 2016-04-22 EP EP20179384.1A patent/EP3750559A1/en active Pending
- 2016-04-22 MA MA051763A patent/MA51763A/fr unknown
- 2016-04-22 TW TW110112383A patent/TW202130658A/zh unknown
- 2016-04-22 RU RU2017137142A patent/RU2723092C2/ru active
- 2016-04-22 AR ARP160101140A patent/AR104675A1/es unknown
- 2016-04-22 EP EP16717663.5A patent/EP3285801A1/en active Pending
- 2016-04-22 KR KR1020177030445A patent/KR20170137119A/ko not_active Application Discontinuation
- 2016-04-22 CN CN202011636461.XA patent/CN112661838A/zh active Pending
- 2016-04-22 NZ NZ734197A patent/NZ734197A/en unknown
- 2016-04-22 IL IL292411A patent/IL292411A/en unknown
- 2016-04-22 MA MA051762A patent/MA51762A/fr unknown
- 2016-04-22 TW TW105112670A patent/TWI737605B/zh active
- 2016-04-22 AU AU2016251621A patent/AU2016251621B2/en active Active
- 2016-04-22 EP EP20179383.3A patent/EP3750558A1/en active Pending
- 2016-04-22 EP EP20179382.5A patent/EP3750557A1/en active Pending
- 2016-04-22 MA MA051761A patent/MA51761A/fr unknown
- 2016-04-22 MA MA052115A patent/MA52115A/fr unknown
- 2016-04-22 MX MX2017013688A patent/MX2017013688A/es unknown
- 2016-04-22 CN CN202011636460.5A patent/CN113045642A/zh active Pending
- 2016-04-22 SG SG10202001482YA patent/SG10202001482YA/en unknown
- 2016-04-22 EA EA201792044A patent/EA201792044A1/ru unknown
- 2016-04-22 MY MYPI2017702617A patent/MY173099A/en unknown
- 2016-04-22 JP JP2017548292A patent/JP6901065B2/ja active Active
- 2016-04-22 BR BR112017017560-6A patent/BR112017017560A2/pt active Search and Examination
- 2016-04-22 CN CN201680023017.6A patent/CN107624118B/zh active Active
- 2016-04-22 MA MA041939A patent/MA41939A/fr unknown
- 2016-04-22 CN CN202011636463.9A patent/CN112679604A/zh active Pending
- 2016-04-22 EP EP20179381.7A patent/EP3760225A3/en active Pending
-
2017
- 2017-07-12 CL CL2017001819A patent/CL2017001819A1/es unknown
- 2017-07-12 PH PH12017501275A patent/PH12017501275A1/en unknown
- 2017-07-20 ZA ZA2017/04939A patent/ZA201704939B/en unknown
- 2017-08-30 CO CONC2017/0008902A patent/CO2017008902A2/es unknown
- 2017-09-24 IL IL254626A patent/IL254626A0/en unknown
- 2017-10-24 MX MX2022005060A patent/MX2022005060A/es unknown
-
2018
- 2018-03-06 HK HK18103193.9A patent/HK1244666A1/zh unknown
-
2019
- 2019-05-23 AU AU2019203625A patent/AU2019203625B2/en active Active
- 2019-07-23 US US16/519,959 patent/US10577402B2/en active Active
- 2019-07-23 US US16/520,003 patent/US10526389B2/en active Active
- 2019-07-23 US US16/519,987 patent/US10550167B2/en active Active
- 2019-12-13 US US16/714,112 patent/US10662233B2/en active Active
-
2020
- 2020-04-13 CL CL2020000987A patent/CL2020000987A1/es unknown
- 2020-04-13 CL CL2020000988A patent/CL2020000988A1/es unknown
- 2020-04-13 CL CL2020000984A patent/CL2020000984A1/es unknown
- 2020-04-13 CL CL2020000985A patent/CL2020000985A1/es unknown
- 2020-04-13 CL CL2020000983A patent/CL2020000983A1/es unknown
- 2020-04-13 CL CL2020000989A patent/CL2020000989A1/es unknown
- 2020-04-13 CL CL2020000986A patent/CL2020000986A1/es unknown
- 2020-06-29 US US16/915,707 patent/US10898559B2/en active Active
- 2020-08-24 AU AU2020223637A patent/AU2020223637B2/en active Active
- 2020-08-24 AU AU2020223638A patent/AU2020223638B2/en active Active
- 2020-08-24 AU AU2020223639A patent/AU2020223639B2/en active Active
- 2020-09-11 US US17/018,572 patent/US10898560B2/en active Active
- 2020-12-09 US US17/116,845 patent/US11027002B2/en active Active
-
2021
- 2021-01-15 US US17/150,617 patent/US11071773B2/en active Active
- 2021-05-17 AU AU2021203138A patent/AU2021203138B2/en active Active
- 2021-05-21 US US17/327,193 patent/US20210275655A1/en active Pending
- 2021-05-24 JP JP2021087277A patent/JP2021168652A/ja active Pending
- 2021-10-15 US US17/502,686 patent/US11324812B2/en active Active
-
2022
- 2022-02-25 US US17/681,447 patent/US20220184194A1/en active Pending
- 2022-02-25 US US17/681,268 patent/US20220184193A1/en active Pending
- 2022-03-04 US US17/687,274 patent/US20220193212A1/en active Pending
- 2022-03-04 US US17/687,297 patent/US20220313805A1/en active Pending
- 2022-03-11 US US17/692,264 patent/US20220211833A1/en active Pending
-
2024
- 2024-03-06 JP JP2024034009A patent/JP2024069322A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU2020113032A (ru) | Новые пептиды и комбинации пептидов для применения в иммунотерапии рака легких, в том числе немелкоклеточного рака легких (нмрл) и других видов рака | |
HRP20202019T1 (hr) | Novi peptidi i kombinacija peptida za uporabu u imunoterapiji protiv raka jajnika i drugih malignih tumora | |
HRP20201281T1 (hr) | Novi peptidi i kombinacija peptida za uporabu u imunoterapiji protiv epitelnog karcinoma jajnika i drugih karcinoma | |
HRP20210698T1 (hr) | Peptidi i kombinacija peptida za uporabu u imunoterapiji protiv karcinoma dojke i drugih karcinoma | |
AR121383A2 (es) | Péptidos y combinación de péptidos y andamiajes para su uso en inmunoterapia contra carcinoma de células renales (rcc) y otros cánceres | |
HRP20210709T1 (hr) | Peptidi i kombinacija peptida za imunoterapiju protiv karcinoma prostate i druge vrste karcinoma | |
EA201892021A1 (ru) | Трансфицированные t-клетки и t-клеточные рецепторы для применения в иммунотерапии раковых заболеваний | |
EA201891759A1 (ru) | Трансфицированные t-клетки и t-клеточные рецепторы для применения в иммунотерапии раковых заболеваний | |
AR106920A1 (es) | Péptidos y combinaciones de péptidos para el uso en la inmunoterapia contra la leucemia linfocítica crónica (llc) y otros tipos de cáncer | |
JP2019516663A5 (ru) | ||
EA202191027A3 (ru) | Новые пептиды и комбинации пептидов для применения в иммунотерапии нескольких видов опухолей | |
EA202091833A1 (ru) | Пептиды и комбинации пептидов неканонического происхождения для применения в иммунотерапии различных видов рака | |
RU2015113378A (ru) | Новые проникающие в клетку пептиды | |
HRP20230512T1 (hr) | Novi peptidi i kombinacija peptida za uporabu u imunoterapiji protiv karcinoma jajnika i drugih karcinoma | |
RU2011138160A (ru) | Пептиды foxmi и вакцины, содержащие их | |
RU2012147590A (ru) | Пептиды cdca5 и содержащие их вакцины | |
RU2012136464A (ru) | Модифицированные пептиды melk и содержащие их вакцины | |
JP2019536426A5 (ru) | ||
HRP20210528T1 (hr) | Novi peptidi i kombinacija peptida i njihovih skela za uporabu u imunoterapiji protiv kolorektalnog karcinoma i drugih karcinoma | |
WO2009123188A1 (ja) | MHCクラスII分子に提示されるサーバイビン(Survivin)の部分ペプチドとその利用法 | |
RU2011150283A (ru) | Пептиды ттк и вакцины, их содержащие | |
HRP20191671T1 (hr) | Nova imunoterapija za liječenje nekoliko tumora krvi, kao što je akutna mijeloidna leukemija (aml) | |
RU2011140168A (ru) | Пептиды vangl1 и содержащие их вакцины | |
TW201619189A (zh) | 來自koc1的胜肽及含其之疫苗 | |
FI3236985T4 (fi) | Uusia peptidejä ja peptidien yhdistelmiä käytettäväksi immunoterapiassa hepatosellulaarista karsinoomaa (hcc) ja muita syöpiä vastaan |