CL2019003405A1 - Péptido asociados a tumor (tumap) aislado; ácido nucleico; vector de expresión; célula huésped recombinante que comprendes el péptido; método para producir el péptido; uso para preparar un medicamento útil rara tratar el cáncer; kit farmacéutico. (divisional solicitud 201702407) - Google Patents
Péptido asociados a tumor (tumap) aislado; ácido nucleico; vector de expresión; célula huésped recombinante que comprendes el péptido; método para producir el péptido; uso para preparar un medicamento útil rara tratar el cáncer; kit farmacéutico. (divisional solicitud 201702407)Info
- Publication number
- CL2019003405A1 CL2019003405A1 CL2019003405A CL2019003405A CL2019003405A1 CL 2019003405 A1 CL2019003405 A1 CL 2019003405A1 CL 2019003405 A CL2019003405 A CL 2019003405A CL 2019003405 A CL2019003405 A CL 2019003405A CL 2019003405 A1 CL2019003405 A1 CL 2019003405A1
- Authority
- CL
- Chile
- Prior art keywords
- peptide
- nucleic acid
- host cell
- tumap
- prepare
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 8
- 238000000034 method Methods 0.000 title abstract 3
- 108020004707 nucleic acids Proteins 0.000 title abstract 3
- 150000007523 nucleic acids Chemical class 0.000 title abstract 3
- 102000039446 nucleic acids Human genes 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 title 2
- 201000011510 cancer Diseases 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000013604 expression vector Substances 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- Chemical Kinetics & Catalysis (AREA)
Abstract
LA INVENCIÓN SE REFIERE A UN PÉPTIDO QUE COMPRENDO LA SECUENCIA DE AMINOÁCIDOS DE LE SEC ID NO 40, O UNA SAL FARMACÉUTICAMENTE ACEPTABLE CE LA MISMA, EN DONDE DICHO PÉPTIDO TIENE UNA LONGITUD TOTAL DE 8 A 30 AMINOÁCIDOS. LA INVENCIÓN TAMBIÉN SE REFIERE A UN ANTICUERPO, EN PARTICULAR UN ANTICUERPO SOLUBLE O UNIDO A LA MEMBRANA, UN ÁCIDO NUCLEICO QUE CODIFICA PARA EL PÉPTIDO, UN VECTOR DE EXPRESIÓN QUE CONTIENE EL ÁCIDO NUCLEICO UNA CÉLULA HUÉSPED, UNA CÉLULA HUÉSPED. LA INVENCIÓN TAMBIÉN DIVULGA EL MÉTODO IN VITRO PARA PRODUCIR EL PÉPTIDO, UN MÉTODO PARA PRODUCIR LINFOCITOS T ACTIVADOS. LA INVENCIÓN TAMBIÉN DIVULGA EL USO DEL PÉPTIDO, UNA COMPOSICIÓN FARMACÉUTICA Y UN KIT.
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US201562139189P | 2015-03-27 | 2015-03-27 | |
GBGB1505305.1A GB201505305D0 (en) | 2015-03-27 | 2015-03-27 | Novel Peptides and combination of peptides for use in immunotherapy against various tumors |
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CL2017002407A CL2017002407A1 (es) | 2015-03-27 | 2017-09-25 | Péptidos y combinación de péptidos novedosos para su uso en inmunoterapia contra diversos tumores |
CL2019003405A CL2019003405A1 (es) | 2015-03-27 | 2019-11-22 | Péptido asociados a tumor (tumap) aislado; ácido nucleico; vector de expresión; célula huésped recombinante que comprendes el péptido; método para producir el péptido; uso para preparar un medicamento útil rara tratar el cáncer; kit farmacéutico. (divisional solicitud 201702407) |
CL2019003407A CL2019003407A1 (es) | 2015-03-27 | 2019-11-22 | Péptido asociados a tumor (tumap) aislado; ácido nucleico; vector de expresión; célula huésped recombinante que comprendes el péptido; método para producir el péptido; uso para preparar un medicamento útil rara tratar el cáncer; kit farmacéutico. (divisional solicitud 201702407) |
CL2019003409A CL2019003409A1 (es) | 2015-03-27 | 2019-11-22 | Péptido asociados a tumor (tumap) aislado; ácido nucleico; vector de expresión; célula huésped recombinante que comprendes el péptido; método para producir el péptido; uso para preparar un medicamento útil rara tratar el cáncer; kit farmacéutico. (divisional solicitud 201702407) |
CL2019003408A CL2019003408A1 (es) | 2015-03-27 | 2019-11-22 | Péptido asociados a tumor (tumap) aislado; ácido nucleico; vector de expresión; célula huésped recombinante que comprendes el péptido; método para producir el péptido; uso para preparar un medicamento útil rara tratar el cáncer; kit farmacéutico. (divisional solicitud 201702407) |
CL2019003406A CL2019003406A1 (es) | 2015-03-27 | 2019-11-22 | Péptido asociados a tumor (tumap) aislado; ácido nucleico; vector de expresión; célula huésped recombinante que comprendes el péptido; método para producir el péptido; uso para preparar un medicamento útil rara tratar el cáncer; kit farmacéutico. (divisional solicitud 201702407) |
CL2019003404A CL2019003404A1 (es) | 2015-03-27 | 2019-11-22 | Péptido asociados a tumor (tumap) aislado; ácido nucleico; vector de expresión; célula huésped recombinante que comprendes el péptido; método para producir el péptido; uso para preparar un medicamento útil rara tratar el cáncer; kit farmacéutico.(divisional solicitud 201702407) |
CL2019003410A CL2019003410A1 (es) | 2015-03-27 | 2019-11-22 | Péptido asociado a tumor (tumap) aislado; ácido nucleico; vector de expresión; célula huésped recombinante que comprende el péptido; método para producir el péptido; uso para preparar un medicamento útil para tratar el cáncer; kit farmacéutico. (divisional solicitud 201702407). |
CL2021001563A CL2021001563A1 (es) | 2015-03-27 | 2021-06-15 | Péptidos y combinación de péptidos novedosos para su uso en inmunoterapia contra diversos tumores (divisional de la solicitud no. 201702407) |
CL2021001565A CL2021001565A1 (es) | 2015-03-27 | 2021-06-15 | Péptidos y combinación de péptidos novedosos para su uso en inmunoterapia contra diversos tumores (divisional de la solicitud no. 201702407) |
CL2021001564A CL2021001564A1 (es) | 2015-03-27 | 2021-06-15 | Péptidos y combinación de péptidos novedosos para su uso en inmunoterapia contra diversos tumores (divisional de la solicitud no. 201702407) |
CL2021002168A CL2021002168A1 (es) | 2015-03-27 | 2021-08-16 | Péptido asociado a tumor; ácido nucleico; vector de expresión; célula huésped recombinante; método para producir el péptido; linfocitos t activados y su método de producción; anticuerpo; tcr; uso para tratar el cáncer; kit y composición farmacéutica; método para producir vacuna; y áptaro (divisional solicitud no. 201702407). |
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CL2019003407A CL2019003407A1 (es) | 2015-03-27 | 2019-11-22 | Péptido asociados a tumor (tumap) aislado; ácido nucleico; vector de expresión; célula huésped recombinante que comprendes el péptido; método para producir el péptido; uso para preparar un medicamento útil rara tratar el cáncer; kit farmacéutico. (divisional solicitud 201702407) |
CL2019003409A CL2019003409A1 (es) | 2015-03-27 | 2019-11-22 | Péptido asociados a tumor (tumap) aislado; ácido nucleico; vector de expresión; célula huésped recombinante que comprendes el péptido; método para producir el péptido; uso para preparar un medicamento útil rara tratar el cáncer; kit farmacéutico. (divisional solicitud 201702407) |
CL2019003408A CL2019003408A1 (es) | 2015-03-27 | 2019-11-22 | Péptido asociados a tumor (tumap) aislado; ácido nucleico; vector de expresión; célula huésped recombinante que comprendes el péptido; método para producir el péptido; uso para preparar un medicamento útil rara tratar el cáncer; kit farmacéutico. (divisional solicitud 201702407) |
CL2019003406A CL2019003406A1 (es) | 2015-03-27 | 2019-11-22 | Péptido asociados a tumor (tumap) aislado; ácido nucleico; vector de expresión; célula huésped recombinante que comprendes el péptido; método para producir el péptido; uso para preparar un medicamento útil rara tratar el cáncer; kit farmacéutico. (divisional solicitud 201702407) |
CL2019003404A CL2019003404A1 (es) | 2015-03-27 | 2019-11-22 | Péptido asociados a tumor (tumap) aislado; ácido nucleico; vector de expresión; célula huésped recombinante que comprendes el péptido; método para producir el péptido; uso para preparar un medicamento útil rara tratar el cáncer; kit farmacéutico.(divisional solicitud 201702407) |
CL2019003410A CL2019003410A1 (es) | 2015-03-27 | 2019-11-22 | Péptido asociado a tumor (tumap) aislado; ácido nucleico; vector de expresión; célula huésped recombinante que comprende el péptido; método para producir el péptido; uso para preparar un medicamento útil para tratar el cáncer; kit farmacéutico. (divisional solicitud 201702407). |
CL2021001563A CL2021001563A1 (es) | 2015-03-27 | 2021-06-15 | Péptidos y combinación de péptidos novedosos para su uso en inmunoterapia contra diversos tumores (divisional de la solicitud no. 201702407) |
CL2021001565A CL2021001565A1 (es) | 2015-03-27 | 2021-06-15 | Péptidos y combinación de péptidos novedosos para su uso en inmunoterapia contra diversos tumores (divisional de la solicitud no. 201702407) |
CL2021001564A CL2021001564A1 (es) | 2015-03-27 | 2021-06-15 | Péptidos y combinación de péptidos novedosos para su uso en inmunoterapia contra diversos tumores (divisional de la solicitud no. 201702407) |
CL2021002168A CL2021002168A1 (es) | 2015-03-27 | 2021-08-16 | Péptido asociado a tumor; ácido nucleico; vector de expresión; célula huésped recombinante; método para producir el péptido; linfocitos t activados y su método de producción; anticuerpo; tcr; uso para tratar el cáncer; kit y composición farmacéutica; método para producir vacuna; y áptaro (divisional solicitud no. 201702407). |
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Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201505305D0 (en) | 2015-03-27 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel Peptides and combination of peptides for use in immunotherapy against various tumors |
DK3388075T5 (da) | 2015-03-27 | 2024-09-23 | Immatics Biotechnologies Gmbh | Hidtil ukendte peptider og kombination af peptider til anvendelse ved immunterapi mod forskellige tumorer |
GB201505585D0 (en) | 2015-03-31 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides and scaffolds for use in immunotherapy against renal cell carinoma (RCC) and other cancers |
GB201512369D0 (en) * | 2015-07-15 | 2015-08-19 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against epithelial ovarian cancer and other cancers |
TW202132326A (zh) * | 2019-11-05 | 2021-09-01 | 美國德州系統大學評議委員會 | Hla限制性hormad1 t細胞受體及其用途 |
MX2022005678A (es) * | 2019-11-11 | 2022-10-18 | Ibi Ag Innovative Bio Insecticides Ltd | Nanocuerpos para el control de insectos y usos de los mismos. |
CN110885366B (zh) * | 2019-12-09 | 2023-04-18 | 崇好科技有限公司 | 肝癌的肿瘤标志物热休克因子2结合蛋白及其应用 |
CN111647626B (zh) * | 2020-06-08 | 2022-07-22 | 中国石油大学(华东) | 多巯基肽自组装及其基因载体应用 |
CN113035298B (zh) * | 2021-04-02 | 2023-06-20 | 南京信息工程大学 | 递归生成大阶数行限制覆盖阵列的药物临床试验设计方法 |
Family Cites Families (169)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8211999B2 (en) | 1970-02-11 | 2012-07-03 | Immatics Biotechnologies Gmbh | Tumor-associated peptides binding promiscuously to human leukocyte antigen (HLA) class II molecules |
US4440859A (en) | 1977-05-27 | 1984-04-03 | The Regents Of The University Of California | Method for producing recombinant bacterial plasmids containing the coding sequences of higher organisms |
US4704362A (en) | 1977-11-08 | 1987-11-03 | Genentech, Inc. | Recombinant cloning vehicle microbial polypeptide expression |
ES487106A0 (es) | 1978-12-22 | 1981-05-16 | Biogen Nv | Un metodo para producir al menos un polipeptido que muestra antigenicidad de hbv |
US4530901A (en) | 1980-01-08 | 1985-07-23 | Biogen N.V. | Recombinant DNA molecules and their use in producing human interferon-like polypeptides |
US4342566A (en) | 1980-02-22 | 1982-08-03 | Scripps Clinic & Research Foundation | Solid phase anti-C3 assay for detection of immune complexes |
US4678751A (en) | 1981-09-25 | 1987-07-07 | Genentech, Inc. | Hybrid human leukocyte interferons |
US4766075A (en) | 1982-07-14 | 1988-08-23 | Genentech, Inc. | Human tissue plasminogen activator |
US4582800A (en) | 1982-07-12 | 1986-04-15 | Hoffmann-La Roche Inc. | Novel vectors and method for controlling interferon expression |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4493795A (en) | 1983-10-17 | 1985-01-15 | Syntex (U.S.A.) Inc. | Synthetic peptide sequences useful in biological and pharmaceutical applications and methods of manufacture |
US4757006A (en) | 1983-10-28 | 1988-07-12 | Genetics Institute, Inc. | Human factor VIII:C gene and recombinant methods for production |
US4677063A (en) | 1985-05-02 | 1987-06-30 | Cetus Corporation | Human tumor necrosis factor |
JPH07108224B2 (ja) | 1985-11-07 | 1995-11-22 | 重三 鵜高 | バチルス・ブレビスを用いる遺伝子の発現方法 |
US4772557A (en) * | 1985-11-12 | 1988-09-20 | Washington University | DNA clone of human skin fibroblast collagenase enzyme |
US4810648A (en) | 1986-01-08 | 1989-03-07 | Rhone Poulenc Agrochimie | Haloarylnitrile degrading gene, its use, and cells containing the gene |
US4897445A (en) | 1986-06-27 | 1990-01-30 | The Administrators Of The Tulane Educational Fund | Method for synthesizing a peptide containing a non-peptide bond |
US9340577B2 (en) | 1992-08-07 | 2016-05-17 | Epimmune Inc. | HLA binding motifs and peptides and their uses |
ES2108460T3 (es) | 1993-06-03 | 1997-12-16 | Therapeutic Antibodies Inc | Fragmentos de anticuerpos en terapeutica. |
AUPM322393A0 (en) | 1993-12-24 | 1994-01-27 | Austin Research Institute, The | Mucin carbohydrate compounds and their use in immunotherapy |
AU6012696A (en) | 1995-06-14 | 1997-01-15 | Aberdeen University | Prognostic and therapeutic system for cancer |
PT879282E (pt) | 1996-01-17 | 2003-11-28 | Imp College Innovations Ltd | Imunoterapia utilizando linfocitos t citotoxicos (ctl) |
US6143509A (en) | 1996-02-06 | 2000-11-07 | Abbott Laboratories | Prostate specific antigen peptides and uses thereof |
US5849589A (en) | 1996-03-11 | 1998-12-15 | Duke University | Culturing monocytes with IL-4, TNF-α and GM-CSF TO induce differentiation to dendric cells |
WO1998010292A1 (en) | 1996-09-06 | 1998-03-12 | Centocor, Inc. | Monoclonal antibodies specific for prostate specific antigen and methods of detecting prostate specific antigen |
US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
US6291430B1 (en) | 1997-09-12 | 2001-09-18 | Ludwig Institute For Cancer Research | Mage-3 peptides presented by HLA class II molecules |
CA2321962C (en) | 1998-02-27 | 2014-07-15 | The Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services | G protein-coupled receptor antagonists |
US7105488B1 (en) | 1998-02-27 | 2006-09-12 | The United States Of America As Represented By The Department Of Health And Human Services | G protein-coupled receptor antagonists |
US6255055B1 (en) | 1998-03-09 | 2001-07-03 | Wisconsin Alumni Research Foundation | c-myc coding region determinant-binding protein (CRD-BP) and its nucleic acid sequence |
US7579160B2 (en) | 1998-03-18 | 2009-08-25 | Corixa Corporation | Methods for the detection of cervical cancer |
US7258860B2 (en) | 1998-03-18 | 2007-08-21 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
US20030236209A1 (en) * | 1998-03-18 | 2003-12-25 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
DE60034601T2 (de) | 1998-09-28 | 2007-12-27 | Bio Polymer Products Of Sweden Ab | Verfahren zur herstellung von polyphenolischen adhäsionsproteinen |
US20070020327A1 (en) | 1998-11-10 | 2007-01-25 | John Fikes | Inducing cellular immune responses to prostate cancer antigens using peptide and nucleic acid compositions |
US7259253B2 (en) | 1999-05-14 | 2007-08-21 | Quark Biotech, Inc. | Genes associated with mechanical stress, expression products therefrom, and uses thereof |
US6869951B1 (en) | 1999-07-16 | 2005-03-22 | Pharmacia Corporation | Method of changing conformation of a matrix metalloproteinase |
US20020123095A1 (en) | 1999-10-20 | 2002-09-05 | Pe Corporation (Ny) | Estrogen receptor alpha variants and methods of detection thereof |
US20040142361A1 (en) | 1999-11-30 | 2004-07-22 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of breast cancer |
EP1235841A4 (en) | 1999-12-10 | 2006-04-12 | Epimmune Inc | TRIGGERING MAGE2 / 3 CELLULAR IMMUNE RESPONSES USING PEPTIDE AND NUCLEIC ACID COMPOSITIONS |
GB2373500B (en) | 2000-02-04 | 2004-12-15 | Aeomica Inc | Methods and apparatus for predicting, confirming, and displaying functional information derived from genomic sequence |
WO2001062924A2 (en) | 2000-02-24 | 2001-08-30 | Pharmacia & Upjohn Company | Human g protein-coupled receptors |
US6934639B1 (en) | 2000-02-25 | 2005-08-23 | Wyeth | Methods for designing agents that interact with MMP-13 |
US7094890B1 (en) | 2000-03-10 | 2006-08-22 | Novartis Ag | Arthritis-associated protein |
WO2001070979A2 (en) | 2000-03-21 | 2001-09-27 | Millennium Pharmaceuticals, Inc. | Genes, compositions, kits, and method for identification, assessment, prevention and therapy of ovarian cancer |
AU785493B2 (en) | 2000-03-27 | 2008-01-03 | Technion Research & Development Foundation Ltd. | Single chain class I major histo-compatibility complexes, constructs encoding same and methods of generating same |
US20040191260A1 (en) | 2003-03-26 | 2004-09-30 | Technion Research & Development Foundation Ltd. | Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof |
US6861234B1 (en) | 2000-04-28 | 2005-03-01 | Mannkind Corporation | Method of epitope discovery |
CN101712721A (zh) | 2000-06-05 | 2010-05-26 | 阿尔托生物科学有限公司 | T细胞受体融合物及共轭物以及其使用方法 |
US20030073622A1 (en) | 2000-06-07 | 2003-04-17 | Kumud Majumder | Novel proteins and nucleic acids encoding same |
WO2002003985A1 (en) | 2000-07-07 | 2002-01-17 | Saint Louis University | Method of modulating expression of ldl-receptor-related protein and uses thereof |
US20030114410A1 (en) | 2000-08-08 | 2003-06-19 | Technion Research And Development Foundation Ltd. | Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis |
US20070014801A1 (en) | 2001-01-24 | 2007-01-18 | Gish Kurt C | Methods of diagnosis of prostate cancer, compositions and methods of screening for modulators of prostate cancer |
EP1455816A4 (en) | 2000-10-19 | 2007-03-28 | Epimmune Inc | HLA CLASS I AND II BINDING PEPTIDES AND THEIR USE |
CA2426405A1 (en) | 2000-10-20 | 2002-05-02 | Applera Corporation | Estrogen receptor alpha variants and methods of detection thereof |
US7919467B2 (en) | 2000-12-04 | 2011-04-05 | Immunotope, Inc. | Cytotoxic T-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of cancer |
US20040053822A1 (en) | 2000-12-11 | 2004-03-18 | John Fikes | Inducing cellular immune responses to mage2/3 using peptide and nucleic acid compositions |
WO2002050277A2 (en) | 2000-12-21 | 2002-06-27 | Curagen Corporation | Protein and nucleic acids encoding same |
WO2002068649A2 (en) | 2001-01-31 | 2002-09-06 | Curagen Corporation | Proteins and nucleic acids encoding same |
US20050069976A1 (en) | 2001-02-14 | 2005-03-31 | Peter Lind | Protein-coupled receptor |
AU2002254615A1 (en) * | 2001-04-17 | 2002-10-28 | The Board Of Trustees Of The University Of Arkansas | Repeat sequences of the ca125 gene and their use for diagnostic and therapeutic interventions |
EP1463928A2 (en) | 2001-04-18 | 2004-10-06 | Protein Design Labs | Methods of diagnosis of lung cancer, compositions and methods of screening for modulators of lung cancer |
US20030077664A1 (en) | 2001-04-18 | 2003-04-24 | Yi Zhao | Methods of screening for compounds that modulate hormone receptor activity |
US20050053918A1 (en) | 2001-05-16 | 2005-03-10 | Technion Research & Development Foundation Ltd. | Method of identifying peptides capable of binding to MHC molecules, peptides identified thereby and their uses |
US6867283B2 (en) | 2001-05-16 | 2005-03-15 | Technion Research & Development Foundation Ltd. | Peptides capable of binding to MHC molecules, cells presenting such peptides, and pharmaceutical compositions comprising such peptides and/or cells |
US7049413B2 (en) | 2001-05-18 | 2006-05-23 | Ludwig Institute For Cancer Research | MAGE-A3 peptides presented by HLA class II molecules |
AU2002330714A1 (en) | 2001-05-30 | 2003-01-02 | Biomedical Center | In silico screening for phenotype-associated expressed sequences |
US7705120B2 (en) | 2001-06-21 | 2010-04-27 | Millennium Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer |
EP1410013A4 (en) | 2001-06-21 | 2006-02-01 | Millennium Pharm Inc | COMPOSITIONS, NEEDS AND METHODS FOR THE IDENTIFICATION, EVALUATION, PREVENTION AND TREATMENT OF BREAST CANCERS AND OVARIA |
EP1446501A2 (en) | 2001-06-25 | 2004-08-18 | Buadbo APS | Methods for identification of cancer cell surface molecules and cancer specific promoters, and therapeutic uses thereof |
US20030108963A1 (en) | 2001-07-25 | 2003-06-12 | Millennium Pharmaceuticals, Inc. | Novel genes, compositions, kit, and methods for identification, assessment, prevention and therapy of prostate cancer |
JP2003088388A (ja) | 2001-09-14 | 2003-03-25 | Herikkusu Kenkyusho:Kk | 新規な全長cDNA |
US20040142325A1 (en) | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
EP1430112A4 (en) | 2001-09-24 | 2005-06-15 | Nuvelo Inc | NEW NUCLEIC ACIDS AND POLYPEPTIDES |
JP2003135075A (ja) | 2001-11-05 | 2003-05-13 | Research Association For Biotechnology | 新規な全長cDNA |
AU2002357747A1 (en) | 2001-12-10 | 2003-06-23 | Millennium Pharmaceuticals Inc. | Novel genes encoding colon cancer antigens |
AU2003207738A1 (en) | 2002-01-29 | 2003-09-02 | Quark Biotech, Inc. | Islr gene and its association with osteoarthritis and other bone and cartilage disorders, expression products derived therefrom, and uses thereof |
US6992176B2 (en) | 2002-02-13 | 2006-01-31 | Technion Research & Development Foundation Ltd. | Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease |
CA2476625A1 (en) | 2002-02-20 | 2003-08-28 | Dyax Corp. | Mhc-peptide complex binding ligands |
US7193069B2 (en) | 2002-03-22 | 2007-03-20 | Research Association For Biotechnology | Full-length cDNA |
DE10225144A1 (de) | 2002-05-29 | 2003-12-18 | Immatics Biotechnologies Gmbh | An MHC-Moleküle bindende Tumor-assoziierte Peptide |
SE0201863D0 (en) | 2002-06-18 | 2002-06-18 | Cepep Ab | Cell penetrating peptides |
US7311914B2 (en) | 2002-08-13 | 2007-12-25 | Ludwig Institute For Cancer Research | MAGE-A4 antigenic peptides and uses thereof |
WO2004014867A2 (en) * | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Matrix metalloproteinase inhibitors and methods for identification of lead compounds |
AU2003295328A1 (en) | 2002-10-02 | 2004-04-23 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
JP4436319B2 (ja) | 2002-10-09 | 2010-03-24 | メディジーン リミテッド | 単鎖組換えt細胞レセプター |
EP2048159B1 (en) | 2002-11-09 | 2014-01-01 | Immunocore Ltd. | T cell receptor display |
JP5479663B2 (ja) | 2002-12-20 | 2014-04-23 | セレラ コーポレーション | 心筋梗塞に関連する遺伝的多型、その検出方法および使用 |
US20050181375A1 (en) | 2003-01-10 | 2005-08-18 | Natasha Aziz | Novel methods of diagnosis of metastatic cancer, compositions and methods of screening for modulators of metastatic cancer |
EP1590485A2 (en) | 2003-01-30 | 2005-11-02 | Applera Corporation | Genetic polymorphisms associated with rheumatoid arthritis, methods of detection and uses thereof |
GB0304068D0 (en) | 2003-02-22 | 2003-03-26 | Avidex Ltd | Substances |
DE10309729A1 (de) | 2003-02-26 | 2004-09-16 | Hinzmann, Bernd, Dr. | Humane Nukleinsäuresequenzen aus Harnblasenkarzinomen |
EP1613774A2 (en) | 2003-03-10 | 2006-01-11 | Applera Corporation | Genetic polymorphisms associated with stenosis, methods of detection and uses thereof |
WO2004113521A1 (en) | 2003-06-18 | 2004-12-29 | Direvo Biotech Ag | New biological entities and the use thereof |
EP1633866A1 (en) | 2003-06-18 | 2006-03-15 | Direvo Biotech AG | New biological entities and the pharmaceutical or diagnostic use thereof |
US7807392B1 (en) | 2003-09-15 | 2010-10-05 | Celera Corporation | Lung disease targets and uses thereof |
EP1892306A3 (en) | 2003-10-06 | 2008-06-11 | Bayer HealthCare AG | Methods and kits for investigating cancer |
WO2005072053A2 (en) | 2004-01-27 | 2005-08-11 | Compugen Ltd. | Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of colon cancer |
US7667001B1 (en) | 2004-01-27 | 2010-02-23 | Compugen Ltd. | Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of lung cancer |
WO2005084116A2 (en) | 2004-01-27 | 2005-09-15 | Compugen Usa, Inc. | Calcium channel variants |
US7569662B2 (en) | 2004-01-27 | 2009-08-04 | Compugen Ltd | Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of lung cancer |
EP2302394A1 (en) | 2004-05-21 | 2011-03-30 | The Institute for Systems Biology | Compositions and methods for quantification of serum glycoproteins |
US7511025B2 (en) | 2004-06-16 | 2009-03-31 | Trustees Of Dartmouth College | Compositions and methods for inhibiting the synthesis or expression of MMP-1 |
WO2006037993A2 (en) | 2004-10-02 | 2006-04-13 | Auvation Limited | Cancer markers |
WO2006067198A2 (en) | 2004-12-22 | 2006-06-29 | Direvo Biotech Ag | Targeted use of engineered enzymes |
US7883858B2 (en) | 2005-01-27 | 2011-02-08 | Institute For Systems Biology | Methods for identifying and monitoring drug side effects |
JP4987698B2 (ja) | 2005-03-31 | 2012-07-25 | 中外製薬株式会社 | 癌関連抗原アナログペプチド、およびその利用 |
US7842467B1 (en) | 2005-05-12 | 2010-11-30 | Celera Corporation | Breast disease targets and uses thereof |
US7521195B1 (en) | 2005-07-21 | 2009-04-21 | Celera Corporation | Lung disease targets and uses thereof |
DK1760089T3 (da) * | 2005-09-05 | 2009-11-16 | Immatics Biotechnologies Gmbh | Tumor-associeret peptides bindende til human leukocyte antigen (HLA) class I eller II molecules og relateret anti-cancer vaccine |
DK1806359T3 (da) | 2005-09-05 | 2010-06-14 | Immatics Biotechnologies Gmbh | Tumorassocierede peptider, der bindes promiskuøst til Humant Leukocyt-Antigen (HLA) klasse II molekyler |
WO2007042169A2 (en) | 2005-10-07 | 2007-04-19 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Matrix metalloproteinase 11 vaccine |
AU2006304605A1 (en) | 2005-10-17 | 2007-04-26 | Institute For Systems Biology | Tissue-and serum-derived glycoproteins and methods of their use |
US20070248628A1 (en) * | 2005-12-06 | 2007-10-25 | Keller Lorraine H | Immunogens in cancer stem cells |
EP2052088A2 (en) | 2006-08-02 | 2009-04-29 | Genizon Biosciences | Genemap of the human genes associated with psoriasis |
AU2007284651B2 (en) | 2006-08-09 | 2014-03-20 | Institute For Systems Biology | Organ-specific proteins and methods of their use |
WO2008053573A1 (fr) | 2006-10-30 | 2008-05-08 | National University Corporation Hokkaido University | Remède pour néoplasme malin |
RU2445972C2 (ru) | 2006-12-29 | 2012-03-27 | Ипсен Фарма С.А.С. | Фармацевтические композиции glp-1 |
PL2338907T3 (pl) | 2007-07-27 | 2016-03-31 | Immatics Biotechnologies Gmbh | Nowe immunogenne epitopy do immunoterapii |
JP5493076B2 (ja) | 2007-08-20 | 2014-05-14 | オンコセラピー・サイエンス株式会社 | Cdca1ペプチド及びこれを含む薬剤 |
WO2009036246A2 (en) * | 2007-09-14 | 2009-03-19 | Immunotope, Inc. | Immunogens that induce cytotoxic t-lymphocytes and their use in prevention, treatment, and diagnosis of cancer |
WO2009102909A2 (en) | 2008-02-15 | 2009-08-20 | Board Of Regents, The University Of Texas System | Anti-cancer vaccines |
TWI395593B (zh) | 2008-03-06 | 2013-05-11 | Halozyme Inc | 可活化的基質降解酵素之活體內暫時性控制 |
WO2009126271A1 (en) | 2008-04-11 | 2009-10-15 | China Synthetic Rubber Corporation | Methods, agents and kits for the detection of cancer |
US20090263574A1 (en) | 2008-04-21 | 2009-10-22 | Quinn Daniel E | Method of restoring an article |
NO2119726T3 (es) * | 2008-05-14 | 2015-05-23 | ||
EP2337795A2 (en) | 2008-10-01 | 2011-06-29 | Dako Denmark A/S | Mhc multimers in cancer vaccines and immune monitoring |
JP2012506551A (ja) | 2008-10-22 | 2012-03-15 | バイオマーカー デザイン フォルシュングス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 骨または軟骨障害の検出および診断のための方法 |
KR101032860B1 (ko) | 2008-10-22 | 2011-05-06 | 한국식품연구원 | 췌장 조직 특이적 유전자 mmp1 |
WO2010102157A1 (en) * | 2009-03-04 | 2010-09-10 | The Regents Of The University Of California | Molecular predictors of biological response to a cenpe inhibitor in cancer |
JP5649589B2 (ja) | 2009-03-06 | 2015-01-07 | ハロザイム インコーポレイテッド | マトリックスメタロプロテアーゼ1の温度感受性突然変異体およびその使用 |
EP2409155A1 (en) | 2009-03-15 | 2012-01-25 | Technion Research and Development Foundation, Ltd. | Soluble hla complexes for use in disease diagnosis |
WO2010125566A2 (en) | 2009-04-27 | 2010-11-04 | Technion Research And Development Foundation Ltd. | Markers for cancer detection |
US9273283B2 (en) | 2009-10-29 | 2016-03-01 | The Trustees Of Dartmouth College | Method of producing T cell receptor-deficient T cells expressing a chimeric receptor |
US9181527B2 (en) | 2009-10-29 | 2015-11-10 | The Trustees Of Dartmouth College | T cell receptor-deficient T cell compositions |
WO2011066265A1 (en) | 2009-11-25 | 2011-06-03 | Ludwig Institute For Cancer Research Ltd. | Cancer testis antigens as biomarkers in non-small cell lung cancer |
CA2789022A1 (en) | 2010-02-04 | 2011-08-11 | Gilead Biologics, Inc. | Antibodies that bind to lysyl oxidase-like 2 (loxl2) and methods of use therefor |
GB201006360D0 (en) | 2010-04-16 | 2010-06-02 | Immatics Biotechnologies Gmbh | Method for differentially quantifying naturally processed HLA-restricted peptides for cancer, autoimmune and infectious diseases immunotherapy development |
MX346786B (es) | 2010-08-17 | 2017-03-31 | Ambrx Inc | Polipeptidos de relaxina modificados y sus usos. |
CA2816225A1 (en) | 2010-10-26 | 2012-05-03 | Technion Research & Development Foundation Ltd. | Antibodies which bind soluble t-cell receptor ligands |
EP2635707B1 (en) | 2010-11-05 | 2019-03-27 | Kyoto University | Method of examining polycystic kidney disease and method of screening for therapeutic agent of the disease |
US20120129843A1 (en) | 2010-11-18 | 2012-05-24 | Yan Zhang | Pyridyl-thiazolyl inhibitors of pro-matrix metalloproteinase activation |
US20130303826A1 (en) | 2011-01-11 | 2013-11-14 | University Health Network | Prognostic signature for oral squamous cell carcinoma |
US20130064901A1 (en) | 2011-04-18 | 2013-03-14 | Agency For Science, Technology And Research | Gene expression profiling for classifying and treating gastric cancer |
US20120302569A1 (en) | 2011-05-25 | 2012-11-29 | Paul Francis Jackson | Phenyl-thiazolyl inhibitors of pro-matrix metalloproteinase activation |
WO2012162468A1 (en) | 2011-05-25 | 2012-11-29 | Janssen Pharmaceutica Nv | Thiazol derivatives as pro -matrix metalloproteinase inhibitors |
US20140221244A1 (en) | 2011-08-31 | 2014-08-07 | Karen Chapman | Methods and Compositions for the Treatment and Diagnosis of Colorectal Cancer |
WO2013036754A2 (en) | 2011-09-09 | 2013-03-14 | The Wistar Institute Of Anatomy And Biology | Methods and compositions for diagnosis of ovarian cancer |
WO2013057586A1 (en) | 2011-10-19 | 2013-04-25 | Oslo Universitetssykehus Hf | Compositions and methods for producing soluble t - cell receptors |
US9091651B2 (en) | 2011-12-21 | 2015-07-28 | Integrated Diagnostics, Inc. | Selected reaction monitoring assays |
WO2013126726A1 (en) | 2012-02-22 | 2013-08-29 | The Trustees Of The University Of Pennsylvania | Double transgenic t cells comprising a car and a tcr and their methods of use |
CN104380106B (zh) | 2012-03-30 | 2017-02-22 | 二见淳一郎 | 用于生产抗体检测试剂的方法及其用途 |
WO2013151664A1 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins |
US9303079B2 (en) | 2012-04-02 | 2016-04-05 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
GB201208293D0 (en) | 2012-05-11 | 2012-06-20 | Circassia Ltd | Hydrochlorice salt of peptide |
EP2669378A1 (en) | 2012-05-31 | 2013-12-04 | Helmut Hanenberg | Cytochrome P450 suicide gene system |
EP3636665B1 (en) | 2012-09-14 | 2022-06-29 | The United States of America, as represented by The Secretary, Department of Health and Human Services | T cell receptors recognizing mhc class ii-restricted mage-a3 |
WO2014071978A1 (en) | 2012-11-08 | 2014-05-15 | Roche Diagnostics Gmbh | Nucleic acids encoding chimeric polypeptides for library screening |
EP3756687A3 (en) | 2012-12-13 | 2021-03-24 | University Of Virginia Patent Foundation | Target peptides for ovarian cancer therapy and diagnostics |
EP2808392A1 (en) | 2013-05-28 | 2014-12-03 | Rheinische Friedrich-Wilhelms-Universität Bonn | Aptamers and use of the aptamers in the diagnosis and treatment of cancer |
WO2015014375A1 (en) | 2013-07-30 | 2015-02-05 | Biontech Ag | Tumor antigens for determining cancer therapy |
TWI819228B (zh) | 2013-08-05 | 2023-10-21 | 德商伊瑪提克斯生物科技有限公司 | 新穎肽類,細胞及其用於治療多種腫瘤的用途,其製造方法及包含其等之醫藥組成物(八) |
DK3388075T5 (da) * | 2015-03-27 | 2024-09-23 | Immatics Biotechnologies Gmbh | Hidtil ukendte peptider og kombination af peptider til anvendelse ved immunterapi mod forskellige tumorer |
GB201505305D0 (en) | 2015-03-27 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel Peptides and combination of peptides for use in immunotherapy against various tumors |
GB201520583D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
DE102017006829B3 (de) | 2017-07-19 | 2018-09-06 | Daimler Ag | Regalsystem |
CA3086923A1 (en) | 2017-12-28 | 2019-07-04 | Gritstone Oncology, Inc. | Antigen-binding proteins targeting shared antigens |
CA3099644A1 (en) | 2018-05-23 | 2019-11-28 | Gritstone Oncology, Inc. | Shared antigens |
KR20220030208A (ko) | 2019-03-30 | 2022-03-10 | 바이오엔테크 유에스 인크. | T 세포 조성물의 제조를 위한 조성물 및 방법, 및 그의 용도 |
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