ES2108460T3 - Fragmentos de anticuerpos en terapeutica. - Google Patents

Fragmentos de anticuerpos en terapeutica.

Info

Publication number
ES2108460T3
ES2108460T3 ES94917087T ES94917087T ES2108460T3 ES 2108460 T3 ES2108460 T3 ES 2108460T3 ES 94917087 T ES94917087 T ES 94917087T ES 94917087 T ES94917087 T ES 94917087T ES 2108460 T3 ES2108460 T3 ES 2108460T3
Authority
ES
Spain
Prior art keywords
therapeutics
antibodies
fragments
container
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94917087T
Other languages
English (en)
Inventor
John Landon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BTG International Inc
Original Assignee
Therapeutic Antibodies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939311507A external-priority patent/GB9311507D0/en
Priority claimed from GB9402593A external-priority patent/GB9402593D0/en
Application filed by Therapeutic Antibodies Inc filed Critical Therapeutic Antibodies Inc
Application granted granted Critical
Publication of ES2108460T3 publication Critical patent/ES2108460T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'

Abstract

UN METODO DE NEUTRALIZACION DE TNF AL EN UN PACIENTE QUE SE BENEFICIA DE DICHA NEUTRALIZACION, QUE COMPRENDE LA ADMINISTRACION AL PACIENTE DE UN FRAGMENTO IGG FAB REACTIVO HACIA EL TNF{AL}. CONVENIENTEMENTE, EL PACIENTE SUFRE DE UN SHOCK SEPTICO O DE LOS SINTOMAS DEL MISMO. SE PREFIERE SI EL FRAGMENTO FAB SE DERIVA DE POLICLONAL IGG.
ES94917087T 1993-06-03 1994-06-03 Fragmentos de anticuerpos en terapeutica. Expired - Lifetime ES2108460T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939311507A GB9311507D0 (en) 1993-06-03 1993-06-03 Antibody fragments
GB9402593A GB9402593D0 (en) 1994-02-10 1994-02-10 Antibody fragments

Publications (1)

Publication Number Publication Date
ES2108460T3 true ES2108460T3 (es) 1997-12-16

Family

ID=26303001

Family Applications (2)

Application Number Title Priority Date Filing Date
ES94917088T Expired - Lifetime ES2138662T3 (es) 1993-06-03 1994-06-03 Produccion de fragmentos de anticuerpos.
ES94917087T Expired - Lifetime ES2108460T3 (es) 1993-06-03 1994-06-03 Fragmentos de anticuerpos en terapeutica.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES94917088T Expired - Lifetime ES2138662T3 (es) 1993-06-03 1994-06-03 Produccion de fragmentos de anticuerpos.

Country Status (16)

Country Link
US (2) US5733742A (es)
EP (3) EP0701571B1 (es)
JP (1) JP2953782B2 (es)
AT (2) ATE183513T1 (es)
AU (2) AU6852594A (es)
CA (1) CA2163032C (es)
DE (2) DE69405102T2 (es)
DK (2) DK0703925T3 (es)
ES (2) ES2138662T3 (es)
FI (1) FI955798A (es)
GB (1) GB2294267B (es)
GR (2) GR3025133T3 (es)
NO (1) NO954643L (es)
NZ (1) NZ266838A (es)
RU (1) RU2139092C1 (es)
WO (2) WO1994029348A2 (es)

Families Citing this family (191)

* Cited by examiner, † Cited by third party
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