PT1086138E - Anticorpos monoclonais, anticorpos de reacção cruzada e método para produzir os mesmos - Google Patents

Anticorpos monoclonais, anticorpos de reacção cruzada e método para produzir os mesmos Download PDF

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Publication number
PT1086138E
PT1086138E PT99928574T PT99928574T PT1086138E PT 1086138 E PT1086138 E PT 1086138E PT 99928574 T PT99928574 T PT 99928574T PT 99928574 T PT99928574 T PT 99928574T PT 1086138 E PT1086138 E PT 1086138E
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PT
Portugal
Prior art keywords
antibodies
cross
producing
same
monoclonal antibodies
Prior art date
Application number
PT99928574T
Other languages
English (en)
Inventor
Avi J Ashkenazi
Anan Chuntharapai
K Jin Kim
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PT1086138E publication Critical patent/PT1086138E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PT99928574T 1998-06-12 1999-06-10 Anticorpos monoclonais, anticorpos de reacção cruzada e método para produzir os mesmos PT1086138E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9663798A 1998-06-12 1998-06-12

Publications (1)

Publication Number Publication Date
PT1086138E true PT1086138E (pt) 2010-01-04

Family

ID=22258333

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99928574T PT1086138E (pt) 1998-06-12 1999-06-10 Anticorpos monoclonais, anticorpos de reacção cruzada e método para produzir os mesmos

Country Status (12)

Country Link
US (1) US20060177456A1 (pt)
EP (2) EP2058334B1 (pt)
JP (2) JP2002517223A (pt)
AT (1) ATE443723T1 (pt)
AU (1) AU4561199A (pt)
CA (1) CA2328498A1 (pt)
DE (1) DE69941453D1 (pt)
ES (2) ES2331901T3 (pt)
HK (1) HK1132750A1 (pt)
IL (3) IL139419A0 (pt)
PT (1) PT1086138E (pt)
WO (1) WO1999064461A2 (pt)

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KR20020093029A (ko) 2000-04-11 2002-12-12 제넨테크, 인크. 다가 항체 및 그의 용도
EP1339426A4 (en) * 2000-11-08 2004-06-30 Human Genome Sciences Inc ANTIBODIES WITH IMMUNOSPECIFIC BINDING TO TRAIL RECEPTORS
DE10157336B4 (de) * 2000-11-24 2007-07-19 Bioserv Analytik Und Medizinprodukte Gmbh Verfahren zur Herstellung eines Testsystems und Diagnoseverfahren zur Erkennung von Pankreasfunktionsstörungen
US7115717B2 (en) 2001-05-18 2006-10-03 Kirin Beer Kabushiki Kaisha Anti-TRAIL-R antibodies
ATE433996T1 (de) 2001-07-03 2009-07-15 Genentech Inc Humane dr4-antikörper und deren anwendungen
EP1756162A1 (en) 2004-03-23 2007-02-28 Biogen Idec MA Inc. Receptor coupling agents and therapeutic uses thereof
US8029783B2 (en) 2005-02-02 2011-10-04 Genentech, Inc. DR5 antibodies and articles of manufacture containing same
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WO2012092376A2 (en) 2010-12-31 2012-07-05 Short Jay M Comprehensive monoclonal antibody generation
EP2727943A1 (en) 2012-11-05 2014-05-07 MAB Discovery GmbH Trispecific antibodies against human EGFR, HER2 and HER3
EP2727941A1 (en) 2012-11-05 2014-05-07 MAB Discovery GmbH Method for the production of multispecific antibodies
EP2914629A1 (en) 2012-11-05 2015-09-09 MAB Discovery GmbH Method for the production of multispecific antibodies
EP2727942A1 (en) 2012-11-05 2014-05-07 MAB Discovery GmbH Bispecific antibodies against human EGFR, HER2, and HER3

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Also Published As

Publication number Publication date
ES2395693T3 (es) 2013-02-14
AU4561199A (en) 1999-12-30
CA2328498A1 (en) 1999-12-16
ES2331901T3 (es) 2010-01-19
EP2058334A3 (en) 2009-05-20
EP2058334A2 (en) 2009-05-13
JP2009112318A (ja) 2009-05-28
EP2058334B1 (en) 2012-10-31
EP1086138A2 (en) 2001-03-28
DE69941453D1 (de) 2009-11-05
IL139419A0 (en) 2001-11-25
WO1999064461A9 (en) 2001-06-28
HK1132750A1 (en) 2010-03-05
ATE443723T1 (de) 2009-10-15
IL139419A (en) 2010-12-30
EP1086138B1 (en) 2009-09-23
US20060177456A1 (en) 2006-08-10
WO1999064461A2 (en) 1999-12-16
WO1999064461A3 (en) 2000-04-20
IL200056A (en) 2010-12-30
JP2002517223A (ja) 2002-06-18

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