MD3331900T2 - Peptide și combinație de peptide pentru utilizare în imunoterapie împotriva cancerului de prostată și altor cancere - Google Patents

Peptide și combinație de peptide pentru utilizare în imunoterapie împotriva cancerului de prostată și altor cancere

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Publication number
MD3331900T2
MD3331900T2 MDE20180586T MDE20180586T MD3331900T2 MD 3331900 T2 MD3331900 T2 MD 3331900T2 MD E20180586 T MDE20180586 T MD E20180586T MD E20180586 T MDE20180586 T MD E20180586T MD 3331900 T2 MD3331900 T2 MD 3331900T2
Authority
MD
Moldova
Prior art keywords
peptides
cells
combination
relates
present
Prior art date
Application number
MDE20180586T
Other languages
English (en)
Inventor
Andrea Mahr
Toni Weinschenk
Oliver Schoor
Jens Fritsche
Harpreet Singh
Phillip Muller
Julia Leibold
Valentina Goldfinger
Original Assignee
Immatics Biotechnologies Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immatics Biotechnologies Gmbh filed Critical Immatics Biotechnologies Gmbh
Publication of MD3331900T2 publication Critical patent/MD3331900T2/ro

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/0602—Vertebrate cells
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    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
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    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
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Abstract

Prezenta invenţie se referă la peptide, proteine, acizi nucleici şi celule pentru utilizare în metode imunoterapeutice. În particular, prezenta invenţie se referă la imunoterapia cancerului. În plus, prezenta invenţie se referă la epitopii peptidici ai celulelor T citotoxice asociate tumorii, singuri sau asociaţi cu alte peptide asociate tumorii, care pot servi, de exemplu, drept componente farmaceutice active ale formulelor de vaccin care stimulează răspunsurile imunitare antitumorale sau pentru stimularea celulelor T ex vivo şi transferarea la pacienţi. Peptidele legate de molecule ale complexului major de histocompatibilitate (MHC), sau peptidele ca atare, pot fi, de asemenea, ţinte ale anticorpilor, ale receptorilor solubili ai celulelor T şi ale altor molecule de legare.
MDE20180586T 2015-08-05 2016-08-05 Peptide și combinație de peptide pentru utilizare în imunoterapie împotriva cancerului de prostată și altor cancere MD3331900T2 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562201289P 2015-08-05 2015-08-05
GBGB1513921.5A GB201513921D0 (en) 2015-08-05 2015-08-06 Novel peptides and combination of peptides for use in immunotherapy against prostate cancer and other cancers
PCT/EP2016/068727 WO2017021527A2 (en) 2015-08-05 2016-08-05 Novel peptides and combination of peptides for use in immunotherapy against prostate cancer and other cancers

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MD3331900T2 true MD3331900T2 (ro) 2021-05-31

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US (24) US9908920B2 (ro)
EP (4) EP3331900B1 (ro)
JP (3) JP6884752B2 (ro)
KR (1) KR20180035845A (ro)
CN (2) CN107849107A (ro)
AR (1) AR105817A1 (ro)
AU (8) AU2016303021B2 (ro)
BR (1) BR112018001687A2 (ro)
CA (3) CA2994771C (ro)
CL (7) CL2018000324A1 (ro)
CO (1) CO2018002202A2 (ro)
CR (6) CR20200432A (ro)
CY (1) CY1123854T1 (ro)
DK (1) DK3331900T3 (ro)
EA (1) EA201890440A1 (ro)
ES (1) ES2862400T3 (ro)
GB (1) GB201513921D0 (ro)
HR (1) HRP20210709T8 (ro)
HU (1) HUE053657T2 (ro)
IL (2) IL310078A (ro)
LT (1) LT3331900T (ro)
MA (4) MA53680A (ro)
MD (1) MD3331900T2 (ro)
MX (2) MX2018001421A (ro)
PE (1) PE20180695A1 (ro)
PH (1) PH12018500189A1 (ro)
PL (1) PL3331900T3 (ro)
PT (1) PT3331900T (ro)
RS (1) RS61713B1 (ro)
SG (1) SG10202001660YA (ro)
SI (1) SI3331900T1 (ro)
TW (3) TWI829618B (ro)
UA (1) UA125816C2 (ro)
WO (1) WO2017021527A2 (ro)
ZA (1) ZA201800513B (ro)

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EP4324472A3 (en) 2024-08-28
US20220152175A1 (en) 2022-05-19
AU2021202059B2 (en) 2023-04-13
IL257331A (en) 2018-03-29
US10376568B2 (en) 2019-08-13
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US20190275131A1 (en) 2019-09-12
US20210283230A1 (en) 2021-09-16
US11786584B2 (en) 2023-10-17
CR20200432A (es) 2020-10-19
US9908920B2 (en) 2018-03-06
PE20180695A1 (es) 2018-04-23
CL2021001545A1 (es) 2022-01-21
HRP20210709T8 (hr) 2022-03-18
PH12018500189A1 (en) 2018-07-30
BR112018001687A2 (pt) 2018-09-18
TW202415673A (zh) 2024-04-16
CL2018000324A1 (es) 2018-05-18
US20210275653A1 (en) 2021-09-09
CR20180074A (es) 2018-07-23
CL2022003264A1 (es) 2023-02-24
CA2994771A1 (en) 2017-02-09
AU2021202059A1 (en) 2021-04-29
AU2021202060B2 (en) 2023-06-15
US20200397878A1 (en) 2020-12-24
AU2021202057A1 (en) 2021-04-29
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UA125816C2 (uk) 2022-06-15

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