MD3430027T2 - Peptide pentru utilizare în imunoterapia împotriva cancerului pulmonar nemicrocelular și a cancerului pulmonar microcelular - Google Patents

Peptide pentru utilizare în imunoterapia împotriva cancerului pulmonar nemicrocelular și a cancerului pulmonar microcelular

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Publication number
MD3430027T2
MD3430027T2 MDE20190100T MDE20190100T MD3430027T2 MD 3430027 T2 MD3430027 T2 MD 3430027T2 MD E20190100 T MDE20190100 T MD E20190100T MD E20190100 T MDE20190100 T MD E20190100T MD 3430027 T2 MD3430027 T2 MD 3430027T2
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MD
Moldova
Prior art keywords
peptides
lung cancer
small cell
cell lung
present disclosure
Prior art date
Application number
MDE20190100T
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English (en)
Inventor
Andrea Mahr
Oliver Schoor
Toni Weinschenk
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Immatics Biotechnologies Gmbh
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Publication date
Application filed by Immatics Biotechnologies Gmbh filed Critical Immatics Biotechnologies Gmbh
Publication of MD3430027T2 publication Critical patent/MD3430027T2/ro

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    • A61K39/461Cellular immunotherapy characterised by the cell type used
    • A61K39/4611T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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Abstract

În general, prezenta descriere se referă la peptide, proteine, acizi nucleici şi celule pentru utilizare în metode imunoterapice. În particular, prezenta descriere se referă la imunoterapia cancerului. Prezenta descriere se referă în plus la epitopi ai peptidelor celulelor T asociate cu tumoarea, singure sau în asociere cu alte peptide asociate tumorilor care pot să servească, de exemplu, ca ingrediente active farmaceutice ale compoziţiilor de vaccinuri care stimulează răspunsuri imune antitumorale, sau pentru a stimula celulele T ex vivo şi transferul la pacienţi. Peptidele legate la moleculele complexului cu histocompatibilitate majoră (MHC), sau peptide ca atare, pot fi, de asemenea, ţinte ale anticorpilor, receptorilor celulelor T solubile şi a altor molecule de legare.
MDE20190100T 2016-03-16 2017-03-15 Peptide pentru utilizare în imunoterapia împotriva cancerului pulmonar nemicrocelular și a cancerului pulmonar microcelular MD3430027T2 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662308944P 2016-03-16 2016-03-16
GBGB1604458.8A GB201604458D0 (en) 2016-03-16 2016-03-16 Peptides and combination of peptides for use in immunotherapy against cancers
PCT/EP2017/056049 WO2017157972A1 (en) 2016-03-16 2017-03-15 Peptides and combination of peptides for use in immunotherapy against non-small cell lung cancer and other cancers

Publications (1)

Publication Number Publication Date
MD3430027T2 true MD3430027T2 (ro) 2024-03-31

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MDE20190100T MD3430027T2 (ro) 2016-03-16 2017-03-15 Peptide pentru utilizare în imunoterapia împotriva cancerului pulmonar nemicrocelular și a cancerului pulmonar microcelular

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US (4) US20170296641A1 (ro)
EP (2) EP3430027B1 (ro)
JP (2) JP2019515650A (ro)
KR (2) KR20180121530A (ro)
CN (1) CN108779149A (ro)
AU (3) AU2017235364B2 (ro)
BR (1) BR112018017022A2 (ro)
CA (1) CA3016410A1 (ro)
CL (2) CL2018002591A1 (ro)
CO (1) CO2018010009A2 (ro)
CR (1) CR20180491A (ro)
DK (1) DK3430027T5 (ro)
EA (1) EA201891701A1 (ro)
ES (1) ES2965011T3 (ro)
FI (1) FI3430027T3 (ro)
GB (1) GB201604458D0 (ro)
HR (1) HRP20231570T1 (ro)
HU (1) HUE064592T2 (ro)
IL (1) IL261785A (ro)
LT (1) LT3430027T (ro)
MA (2) MA43719B1 (ro)
MD (1) MD3430027T2 (ro)
MX (1) MX2018011215A (ro)
PE (1) PE20181824A1 (ro)
PH (1) PH12018501865A1 (ro)
PL (1) PL3430027T3 (ro)
PT (1) PT3430027T (ro)
RS (1) RS64907B1 (ro)
SG (2) SG10202006119TA (ro)
SI (1) SI3430027T1 (ro)
UA (1) UA128576C2 (ro)
WO (1) WO2017157972A1 (ro)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3430030T5 (da) * 2016-03-16 2024-09-23 Immatics Biotechnologies Gmbh Transficerede t-celler og t-cellereceptorer til anvendelse i immunoterapi mod cancer
JP7075125B2 (ja) 2016-05-25 2022-05-25 イマティクス バイオテクノロジーズ ゲーエムベーハー 標的としてのおよび胆嚢がんおよび胆管がんおよびその他のがんに対する免疫療法で使用するための新規ペプチド、ペプチド組み合わせ
GB201609193D0 (en) 2016-05-25 2016-07-06 Immatics Biotechnologies Gmbh Novel peptides, combination of peptides as targets for use in immunotherapy against gallbladder cancer and cholangiocarcinoma and other cancers
EP3539562A1 (en) 2018-03-12 2019-09-18 Eberhard Karls Universität Tübingen Medizinische Fakultät Immunotherapeutic peptides
DE102018108612A1 (de) 2018-03-21 2019-09-26 Immatics US, Inc. Verfahren zur erhöhung der persistenz von adoptiv infundierten t-zellen
CN113412123A (zh) * 2018-12-28 2021-09-17 豪夫迈·罗氏有限公司 用于免疫应答增强的患者的治疗性用途的肽-mhc-i-抗体融合蛋白
KR20220029584A (ko) 2019-05-27 2022-03-08 이매틱스 유에스 인코포레이티드 바이러스 벡터 및 입양 세포 요법에서 그 사용
WO2020245326A1 (en) 2019-06-06 2020-12-10 Immatics Biotechnologies Gmbh Sorting with counter selection using sequence similar peptides
DE102019121007A1 (de) * 2019-08-02 2021-02-04 Immatics Biotechnologies Gmbh Antigenbindende Proteine, die spezifisch an MAGE-A binden
EP3827840A1 (en) * 2019-11-29 2021-06-02 Academisch Ziekenhuis Leiden h.o.d.n. LUMC Teipp peptide variant and uses thereof
DE102021100038A1 (de) 2020-12-31 2022-06-30 Immatics US, Inc. Modifizierte cd8-polypeptide, zusammensetzungen und verfahren zu deren verwendung
CA3203118A1 (en) 2020-12-31 2022-07-07 Gagan BAJWA Cd8 polypeptides, compositions, and methods of using thereof
CN113173986B (zh) * 2021-03-24 2022-01-07 深圳市新靶向生物科技有限公司 一种与肺癌驱动基因突变相关的抗原肽及其应用
CN113087801B (zh) * 2021-04-07 2022-07-05 深圳市核子基因科技有限公司 一种用核酸和抗体联合检测肺癌的试剂盒
BR112023022975A2 (pt) 2021-05-05 2024-01-23 Immatics Biotechnologies Gmbh Polipeptídeos de ligação ao antígeno bma031 melhorados
CN114230636B (zh) * 2021-11-12 2023-04-25 四川大学 一类多肽及其应用以及含该类多肽的药物
US20240066127A1 (en) 2022-04-28 2024-02-29 Immatics US, Inc. Il-12 polypeptides, il-15 polypeptides, il-18 polypeptides, cd8 polypeptides, compositions, and methods of using thereof
US20230348548A1 (en) 2022-04-28 2023-11-02 Immatics US, Inc. Membrane-bound il-15, cd8 polypeptides, cells, compositions, and methods of using thereof
US20230348561A1 (en) 2022-04-28 2023-11-02 Immatics US, Inc. Dominant negative tgfbeta receptor polypeptides, cd8 polypeptides, cells, compositions, and methods of using thereof
WO2023215825A1 (en) 2022-05-05 2023-11-09 Immatics US, Inc. Methods for improving t cell efficacy
CN115785208B (zh) * 2022-06-10 2024-07-12 河北博海生物工程开发有限公司 肺癌特异性分子靶标01及其用途
CN115785207B (zh) * 2022-06-10 2024-08-30 河北博海生物工程开发有限公司 肺癌特异性分子靶标02及其用途
WO2024077601A1 (en) * 2022-10-14 2024-04-18 Guangdong Tcrcure Biopharma Technology Co., Ltd. Peptide vaccines against glioma and uses thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001041741A1 (en) * 1999-12-13 2001-06-14 Epimmune Inc. Hla class i a2 tumor associated antigen peptides and vaccine compositions
AU2002227498A1 (en) * 2000-07-31 2002-02-13 Kyogo Itoh Tumor antigen
CN101160524A (zh) * 2005-02-24 2008-04-09 西米尼斯公司 用于生物样品分类的组合物和方法
PL2338907T3 (pl) * 2007-07-27 2016-03-31 Immatics Biotechnologies Gmbh Nowe immunogenne epitopy do immunoterapii
NO2119726T3 (ro) * 2008-05-14 2015-05-23
TW201008574A (en) * 2008-08-19 2010-03-01 Oncotherapy Science Inc INHBB epitope peptides and vaccines containing the same
WO2011066265A1 (en) * 2009-11-25 2011-06-03 Ludwig Institute For Cancer Research Ltd. Cancer testis antigens as biomarkers in non-small cell lung cancer
GB201004551D0 (en) * 2010-03-19 2010-05-05 Immatics Biotechnologies Gmbh NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer
CN101870725B (zh) * 2010-06-29 2012-06-27 郑州大学 Mage-4抗肿瘤ctl表位肽及其应用
JP6041314B2 (ja) * 2011-08-31 2016-12-07 国立大学法人三重大学 がん治療用ワクチン製剤
TWI819228B (zh) * 2013-08-05 2023-10-21 德商伊瑪提克斯生物科技有限公司 新穎肽類,細胞及其用於治療多種腫瘤的用途,其製造方法及包含其等之醫藥組成物(八)
GB201319446D0 (en) * 2013-11-04 2013-12-18 Immatics Biotechnologies Gmbh Personalized immunotherapy against several neuronal and brain tumors
WO2015172843A1 (en) * 2014-05-16 2015-11-19 Biontech Diagnostics Gmbh Methods and kits for the diagnosis of cancer
CN107075479A (zh) * 2014-10-02 2017-08-18 美国卫生和人力服务部 分离对癌症特异性突变具有抗原特异性的t细胞的方法
CN105219714A (zh) * 2015-10-20 2016-01-06 上海隆耀生物科技有限公司 一种用于激活肺癌特异性免疫反应的试剂盒
DK3430030T5 (da) * 2016-03-16 2024-09-23 Immatics Biotechnologies Gmbh Transficerede t-celler og t-cellereceptorer til anvendelse i immunoterapi mod cancer

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