AR104114A1 - Péptidos y combinación de péptidos y andamiajes para su uso en inmunoterapia contra carcinoma de células renales (rcc) y otros cánceres - Google Patents
Péptidos y combinación de péptidos y andamiajes para su uso en inmunoterapia contra carcinoma de células renales (rcc) y otros cánceresInfo
- Publication number
- AR104114A1 AR104114A1 ARP160100819A ARP160100819A AR104114A1 AR 104114 A1 AR104114 A1 AR 104114A1 AR P160100819 A ARP160100819 A AR P160100819A AR P160100819 A ARP160100819 A AR P160100819A AR 104114 A1 AR104114 A1 AR 104114A1
- Authority
- AR
- Argentina
- Prior art keywords
- cancer
- peptide
- seq
- variant
- antigen
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 12
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 2
- 201000009030 Carcinoma Diseases 0.000 title 1
- 238000009169 immunotherapy Methods 0.000 title 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 3
- 239000000427 antigen Substances 0.000 abstract 3
- 108091007433 antigens Proteins 0.000 abstract 3
- 102000036639 antigens Human genes 0.000 abstract 3
- 210000000612 antigen-presenting cell Anatomy 0.000 abstract 2
- 238000000338 in vitro Methods 0.000 abstract 2
- 108091023037 Aptamer Proteins 0.000 abstract 1
- 208000003174 Brain Neoplasms Diseases 0.000 abstract 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 206010009944 Colon cancer Diseases 0.000 abstract 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 abstract 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 abstract 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract 1
- 102000043129 MHC class I family Human genes 0.000 abstract 1
- 108091054437 MHC class I family Proteins 0.000 abstract 1
- 102000043131 MHC class II family Human genes 0.000 abstract 1
- 108091054438 MHC class II family Proteins 0.000 abstract 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 abstract 1
- 206010033128 Ovarian cancer Diseases 0.000 abstract 1
- 206010061535 Ovarian neoplasm Diseases 0.000 abstract 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 abstract 1
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 208000005718 Stomach Neoplasms Diseases 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 238000010276 construction Methods 0.000 abstract 1
- 239000012636 effector Substances 0.000 abstract 1
- 201000004101 esophageal cancer Diseases 0.000 abstract 1
- 206010017758 gastric cancer Diseases 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 201000007270 liver cancer Diseases 0.000 abstract 1
- 208000014018 liver neoplasm Diseases 0.000 abstract 1
- 201000005202 lung cancer Diseases 0.000 abstract 1
- 208000020816 lung neoplasm Diseases 0.000 abstract 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 230000002018 overexpression Effects 0.000 abstract 1
- 201000002528 pancreatic cancer Diseases 0.000 abstract 1
- 208000008443 pancreatic carcinoma Diseases 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 201000011549 stomach cancer Diseases 0.000 abstract 1
- 239000003053 toxin Substances 0.000 abstract 1
- 231100000765 toxin Toxicity 0.000 abstract 1
Classifications
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- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Abstract
Reivindicación 1: Un péptido caracterizado porque comprende una secuencia de aminoácidos que se elige del grupo que consiste en SEQ ID Nº 1 a SEQ ID Nº 114, y secuencias variantes de las mismas que son por lo menos 88% homólogas a SEQ ID Nº 1 a SEQ ID Nº 114; y una sal farmacéuticamente aceptable de las mismas, en donde dicho péptido no es un polipéptido de longitud completa. Reivindicación 7: Un ácido nucleico, caracterizado porque codifica para un péptido o variante del mismo de acuerdo a cualquiera de las reivindicaciones 1 a 6, opcionalmente conectado a una secuencia promotora heteróloga. Reivindicación 12: Un método in vitro para producir linfocitos T activados, caracterizado porque el método comprende poner en contacto in vitro células T con moléculas MHC de clase I o II humanas cargadas con antígeno expresadas sobre la superficie de una célula presentadora de antígeno adecuada o una construcción artificial que imita una célula presentadora de antígeno durante un periodo de tiempo suficiente para activar a dichas células T de una forma específica de antígeno, en donde dicho antígeno es un péptido de acuerdo a cualquiera de las reivindicaciones 1 a 6. Reivindicación 15: Un anticuerpo, en particular un anticuerpo soluble o unido a membrana, caracterizado porque reconoce específicamente el péptido o variante del mismo de acuerdo a cualquiera de las reivindicaciones 1 a 5, preferiblemente el péptido o variante del mismo de acuerdo a cualquiera de las reivindicaciones 1 a 5 cuando está unido a una molécula MHC en donde el anticuerpo porta una función efectora adicional tal como un dominio o toxina de estimulación inmune. Reivindicación 18: El uso de acuerdo a la reivindicación 16, caracterizado porque dicho cáncer se elige del grupo de cáncer de pulmón, cáncer de cerebro, cáncer gástrico, cáncer colorrectal, cáncer hepático, cáncer pancreático, cáncer de próstata, leucemia, cáncer de mama, melanoma, cáncer ovárico, y cáncer esofágico y otros tumores que muestran una sobreexpresión de de la que deriva el péptido de SEQ ID Nº 1 a SEQ ID Nº 114. Reivindicación 40: Un aptámero caracterizado porque reconoce específicamente el péptido o variante del mismo de acuerdo a cualquiera de las reivindicaciones 1 a 5, preferiblemente el péptido o variante del mismo de acuerdo a cualquiera de las reivindicaciones 1 a 5 que está unido a una molécula de MHC.
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PCT/EP2016/056601 WO2016156230A1 (en) | 2015-03-31 | 2016-03-24 | Novel peptides and combination of peptides and scaffolds for use in immunotherapy against renal cell carcinoma (rcc) and other cancers |
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