MX2021013219A - Celulas que expresan un receptor recombinante de un locus de tgfbr2 modificado, polinucleotidos relacionados y metodos. - Google Patents

Celulas que expresan un receptor recombinante de un locus de tgfbr2 modificado, polinucleotidos relacionados y metodos.

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Publication number
MX2021013219A
MX2021013219A MX2021013219A MX2021013219A MX2021013219A MX 2021013219 A MX2021013219 A MX 2021013219A MX 2021013219 A MX2021013219 A MX 2021013219A MX 2021013219 A MX2021013219 A MX 2021013219A MX 2021013219 A MX2021013219 A MX 2021013219A
Authority
MX
Mexico
Prior art keywords
cells
tgfbr2
recombinant receptor
engineered
locus
Prior art date
Application number
MX2021013219A
Other languages
English (en)
Inventor
Fred Harbinski
Christopher Wilson
G Grant Welstead
Stephen Michael Burleigh
Christopher Heath Nye
Blythe D Sather
Queenie Vong
Melissa Chin
Cedric Cleyrat
Original Assignee
Juno Therapeutics Inc
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Filing date
Publication date
Application filed by Juno Therapeutics Inc filed Critical Juno Therapeutics Inc
Publication of MX2021013219A publication Critical patent/MX2021013219A/es

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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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Abstract

En la presente se proporcionan células inmunitarias modificadas, por ejemplo, células T, que expresan un receptor recombinante, que contienen un locus del receptor del factor beta de crecimiento transformante modificado tipo 2 (TGFBR2) que codifica para el receptor recombinante o una porción del mismo. En algunos aspectos, las células se modifican mediante integración dirigida de una secuencia transgénica que codifica para el receptor recombinante o una porción del mismo, en un locus genómico de TGFBR2. También se proporcionan composiciones celulares que contienen las células inmunitarias modificadas, ácidos nucleicos para células modificadas y métodos, kits y artículos de elaboración para producir las células modificadas, tal como dirigirse a una secuencia transgénica que codifica para un receptor recombinante o una porción del mismo para su integración en una región de un locus genómico de TGFBR2. En algunas modalidades, las células modificadas, por ejemplo, células T, se pueden usar con relación a la terapia celular, incluso con relación a la inmunoterapia contra el cáncer que comprende la transferencia adoptiva de las células modificadas.
MX2021013219A 2019-05-01 2020-04-30 Celulas que expresan un receptor recombinante de un locus de tgfbr2 modificado, polinucleotidos relacionados y metodos. MX2021013219A (es)

Applications Claiming Priority (2)

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US201962841575P 2019-05-01 2019-05-01
PCT/US2020/030815 WO2020223535A1 (en) 2019-05-01 2020-04-30 Cells expressing a recombinant receptor from a modified tgfbr2 locus, related polynucleotides and methods

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MX2021013219A true MX2021013219A (es) 2022-02-17

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US (1) US20220184131A1 (es)
EP (1) EP3962520A1 (es)
JP (1) JP2022531222A (es)
KR (1) KR20220016475A (es)
CN (1) CN114025788A (es)
AU (1) AU2020265741A1 (es)
CA (1) CA3136737A1 (es)
IL (1) IL287207A (es)
MA (1) MA55811A (es)
MX (1) MX2021013219A (es)
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WO (1) WO2020223535A1 (es)

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WO2022232840A1 (en) * 2021-04-29 2022-11-03 The Regents Of The University Of California Systems and methods for genetic editing with increased efficiency
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CN115918611A (zh) * 2021-10-25 2023-04-07 百奥赛图(北京)医药科技股份有限公司 Tgfbr2基因人源化非人动物及其构建方法和应用
WO2023081900A1 (en) 2021-11-08 2023-05-11 Juno Therapeutics, Inc. Engineered t cells expressing a recombinant t cell receptor (tcr) and related systems and methods
US20230372485A1 (en) * 2021-11-15 2023-11-23 Neogene Therapeutics B.V. Engineered t cells with reduced tgf-beta receptor signaling
WO2023111913A1 (en) * 2021-12-15 2023-06-22 Crispr Therapeutics Ag Engineered anti-liv1 cell with regnase-1 and/or tgfbrii disruption
US20230303713A1 (en) * 2022-03-23 2023-09-28 Crispr Therapeutics Ag Anti-cd19 car-t cells with multiple gene edits and therapeutic uses thereof
KR20240040035A (ko) * 2022-09-16 2024-03-27 한국과학기술연구원 유전자 가위 넉-인을 이용하여 제조한 키메릭 항원 수용체 세포 및 이의 용도

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