MX2020009359A - Sistemas de celulas terapeuticas y metodos para el tratamiento de cancer y enfermedades infecciosas. - Google Patents

Sistemas de celulas terapeuticas y metodos para el tratamiento de cancer y enfermedades infecciosas.

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Publication number
MX2020009359A
MX2020009359A MX2020009359A MX2020009359A MX2020009359A MX 2020009359 A MX2020009359 A MX 2020009359A MX 2020009359 A MX2020009359 A MX 2020009359A MX 2020009359 A MX2020009359 A MX 2020009359A MX 2020009359 A MX2020009359 A MX 2020009359A
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Mexico
Prior art keywords
methods
infectious diseases
cells
treating cancer
cell systems
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MX2020009359A
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English (en)
Inventor
Sivan Elloul
Thomas Joseph Wickham
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Rubius Therapeutics Inc
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Publication of MX2020009359A publication Critical patent/MX2020009359A/es

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12N5/0641—Erythrocytes
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/46—Cellular immunotherapy
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    • A61K39/4644—Cancer antigens
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/50—Colon
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    • A61K2239/57—Skin; melanoma
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere
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    • C12N2510/00—Genetically modified cells
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

La presente invención se refiere a las células eritroides que se han diseñado para incluir, por ejemplo, en la superficie de la célula, uno o más polipéptidos estimulantes exógenos, en donde los polipéptidos estimulantes exógenos presentados son suficientes para la estimulación de una célula aniquiladora inmunitaria. Las células enucleadas diseñadas de la presente invención son útiles en los métodos para activar las células NK y/o las células T CD8+ en un sujeto que lo necesite, tal como los sujetos que tienen cáncer o una enfermedad infecciosa, y en particular los cánceres o las enfermedades infecciosas caracterizadas por una regulación hacia abajo de la presentación del MHC clase I.
MX2020009359A 2018-03-08 2019-03-08 Sistemas de celulas terapeuticas y metodos para el tratamiento de cancer y enfermedades infecciosas. MX2020009359A (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862640530P 2018-03-08 2018-03-08
US201862660657P 2018-04-20 2018-04-20
US201862680490P 2018-06-04 2018-06-04
US201862692487P 2018-06-29 2018-06-29
US201862732050P 2018-09-17 2018-09-17
US201862757717P 2018-11-08 2018-11-08
PCT/US2019/021490 WO2019173798A1 (en) 2018-03-08 2019-03-08 Therapeutic cell systems and methods for treating cancer and infectious diseases

Publications (1)

Publication Number Publication Date
MX2020009359A true MX2020009359A (es) 2021-01-29

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MX2020009359A MX2020009359A (es) 2018-03-08 2019-03-08 Sistemas de celulas terapeuticas y metodos para el tratamiento de cancer y enfermedades infecciosas.

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Country Link
US (2) US11141433B2 (es)
EP (1) EP3762422A1 (es)
JP (1) JP2021514665A (es)
KR (1) KR20200140279A (es)
CN (1) CN112105723A (es)
AU (1) AU2019232012A1 (es)
CA (1) CA3093387A1 (es)
IL (1) IL277159A (es)
MX (1) MX2020009359A (es)
RU (1) RU2020132924A (es)
SG (1) SG11202008261WA (es)
WO (1) WO2019173798A1 (es)

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CN111849896B (zh) * 2020-07-31 2022-07-01 广东昭泰体内生物医药科技有限公司 一种car-nk细胞培养基及其应用
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TW202241470A (zh) 2021-01-08 2022-11-01 美商盧比亞斯治療公司 治療人類個體腫瘤之方法
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TW202317179A (zh) 2021-06-03 2023-05-01 美商盧比亞斯治療公司 在個體中治療ｈｐｖ１６－陽性或ｈｐｖ１６－相關的癌症之方法
CN113599395B (zh) * 2021-09-22 2022-08-12 郑州源创吉因实业有限公司 含有nk细胞的治疗癌症的药物组合物
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US20190298769A1 (en) 2019-10-03
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